José Alcides Almeida de Arruda, Gerhilde Callou Sampaio, Victor Zanetti Drumond, Lucas Guimarães Abreu, Bruno Augusto Benevenuto de Andrade, Ricardo Alves Mesquita
Objectives: Spongiotic gingival hyperplasia (SGH) is an uncommon benign, non-plaque-induced epithelial proliferation for which optimal management remains undefined. We describe the case of SGH treated by ablative therapy with a high-power diode laser and summarize previously reported laser-treated cases from the literature.
Methods: An 11-year-old boy presented with a bright-red, granular enlargement of the marginal and attached gingiva adjacent to the mandibular left canine and first premolar. Electronic search was performed in PubMed/MEDLINE, Scopus, Embase, Web of Science, and LILACS to identify studies reporting laser management of SGH.
Results: The lesion was irradiated using an indium-gallium-arsenide diode laser (808 nm, continuous-wave mode, 1.5 W, 748 J, 499 s). Postoperative evaluation revealed excellent hemostasis, preservation of gingival contour, and complete clinical healing without recurrence at 4 months. Five articles comprising eight cases were retrieved. Reported modalities included CO2 and Nd:YAG lasers and photodynamic therapy with a diode laser. All achieved favorable outcomes, with complete or near-complete remission and no recurrence during 5-24 months of follow-up.
Conclusions: This is the first documented case of SGH managed with high-power diode laser ablation, demonstrating both safety and favorable esthetic outcomes, thereby expanding current therapeutic perspectives for this condition.
目的：海绵状牙龈增生（SGH）是一种罕见的良性、非斑块诱导的上皮增生，其最佳治疗方法尚不明确。我们描述了用高功率二极管激光消融治疗SGH的病例，并总结了文献中先前报道的激光治疗病例。方法：一名11岁的男孩，在下颌左犬齿和第一前磨牙附近的边缘和附着龈处出现了亮红色的颗粒状肿大。在PubMed/MEDLINE、Scopus、Embase、Web of Science和LILACS中进行电子检索，以确定报道SGH激光治疗的研究。结果：采用铟镓砷化二极管激光（808 nm，连续波模式，1.5 W, 748 J, 499 s）照射病灶。术后评估显示止血效果良好，牙龈轮廓保持良好，4个月临床完全愈合，无复发。检索到5篇文章，包括8个病例。报道的治疗方法包括CO2和Nd:YAG激光以及二极管激光的光动力治疗。所有患者均获得了良好的结果，在5-24个月的随访中完全或接近完全缓解且无复发。结论：这是第一例用大功率二极管激光消融治疗SGH的病例，证明了安全性和良好的美观效果，从而扩大了目前这种情况的治疗前景。
{"title":"Spongiotic Gingival Hyperplasia Treated With an 808-nm High-Power Diode Laser: A Case Report and Literature Review.","authors":"José Alcides Almeida de Arruda, Gerhilde Callou Sampaio, Victor Zanetti Drumond, Lucas Guimarães Abreu, Bruno Augusto Benevenuto de Andrade, Ricardo Alves Mesquita","doi":"10.1002/lsm.70114","DOIUrl":"https://doi.org/10.1002/lsm.70114","url":null,"abstract":"<p><strong>Objectives: </strong>Spongiotic gingival hyperplasia (SGH) is an uncommon benign, non-plaque-induced epithelial proliferation for which optimal management remains undefined. We describe the case of SGH treated by ablative therapy with a high-power diode laser and summarize previously reported laser-treated cases from the literature.</p><p><strong>Methods: </strong>An 11-year-old boy presented with a bright-red, granular enlargement of the marginal and attached gingiva adjacent to the mandibular left canine and first premolar. Electronic search was performed in PubMed/MEDLINE, Scopus, Embase, Web of Science, and LILACS to identify studies reporting laser management of SGH.</p><p><strong>Results: </strong>The lesion was irradiated using an indium-gallium-arsenide diode laser (808 nm, continuous-wave mode, 1.5 W, 748 J, 499 s). Postoperative evaluation revealed excellent hemostasis, preservation of gingival contour, and complete clinical healing without recurrence at 4 months. Five articles comprising eight cases were retrieved. Reported modalities included CO<sub>2</sub> and Nd:YAG lasers and photodynamic therapy with a diode laser. All achieved favorable outcomes, with complete or near-complete remission and no recurrence during 5-24 months of follow-up.</p><p><strong>Conclusions: </strong>This is the first documented case of SGH managed with high-power diode laser ablation, demonstrating both safety and favorable esthetic outcomes, thereby expanding current therapeutic perspectives for this condition.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabella S Gonçalves, Jennifer M Soares, Vanderlei S Bagnato, Kate C Blanco
Objective: Evaluated the antimicrobial efficacy of curcumin-mediated photodynamic inactivation (PDI) against both sensitive and resistant strains of Streptococcus pneumoniae and Streptococcus pyogenes, as well as its potential to enhance antibiotic effects (amoxicillin, ceftriaxone, erythromycin).
Methodology: The minimum inhibitory concentrations of antibiotics A, B, and C were evaluated in S. pneumoniae and S. pyogenes strains using serial microdilution. Additionally, the photodynamic action of curcumin as a photosensitizer was examined in multiwell plates, which were then irradiated with a 450-nm LED. The effect of the combination over time was determined by colony-forming units per milliliter, using the determined subinhibitory parameters of antibiotics and PDI.
Results: PDI alone significantly reduced bacterial viability, achieving over 3-log reductions at optimal conditions (2.5 µM curcumin, 6.4 J/cm2). When combined with antibiotics, PDI markedly enhanced bactericidal activity, particularly with β-lactams, producing up to 2.8 log greater reductions than antibiotics alone. Notably, three consecutive PDI treatments led to substantial MIC reductions, up to 128-fold for S. pyogenes. We identified that the synergistic effect of curcumin-PDI is highly time-dependent, revealing a dynamic susceptibility window that can be exploited for enhanced antibiotic action. These results support curcumin-PDI as both an antimicrobial tool and a sensitizer agent that enhances antibiotic efficacy.
Conclusion: The study highlights that optimal timing of PDI application is key to maximizing its synergistic effects with antibiotics, revealing that PDI is most effective when applied during specific stages of bacterial response to antibiotic stress, potentially redefining adjuvant treatment strategies.
{"title":"Targeting the Dynamic Susceptibility Window: Time-Sensitive Photodynamic Synergy With Antibiotics Against Streptococcus spp.","authors":"Isabella S Gonçalves, Jennifer M Soares, Vanderlei S Bagnato, Kate C Blanco","doi":"10.1002/lsm.70116","DOIUrl":"https://doi.org/10.1002/lsm.70116","url":null,"abstract":"<p><strong>Objective: </strong>Evaluated the antimicrobial efficacy of curcumin-mediated photodynamic inactivation (PDI) against both sensitive and resistant strains of Streptococcus pneumoniae and Streptococcus pyogenes, as well as its potential to enhance antibiotic effects (amoxicillin, ceftriaxone, erythromycin).</p><p><strong>Methodology: </strong>The minimum inhibitory concentrations of antibiotics A, B, and C were evaluated in S. pneumoniae and S. pyogenes strains using serial microdilution. Additionally, the photodynamic action of curcumin as a photosensitizer was examined in multiwell plates, which were then irradiated with a 450-nm LED. The effect of the combination over time was determined by colony-forming units per milliliter, using the determined subinhibitory parameters of antibiotics and PDI.</p><p><strong>Results: </strong>PDI alone significantly reduced bacterial viability, achieving over 3-log reductions at optimal conditions (2.5 µM curcumin, 6.4 J/cm<sup>2</sup>). When combined with antibiotics, PDI markedly enhanced bactericidal activity, particularly with β-lactams, producing up to 2.8 log greater reductions than antibiotics alone. Notably, three consecutive PDI treatments led to substantial MIC reductions, up to 128-fold for S. pyogenes. We identified that the synergistic effect of curcumin-PDI is highly time-dependent, revealing a dynamic susceptibility window that can be exploited for enhanced antibiotic action. These results support curcumin-PDI as both an antimicrobial tool and a sensitizer agent that enhances antibiotic efficacy.</p><p><strong>Conclusion: </strong>The study highlights that optimal timing of PDI application is key to maximizing its synergistic effects with antibiotics, revealing that PDI is most effective when applied during specific stages of bacterial response to antibiotic stress, potentially redefining adjuvant treatment strategies.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jusleen Ahluwalia, Amanda F Marsch, Kayla Zafar, Sara E Garrido, Arisa E Ortiz
Background: Existing data on basal cell carcinoma (BCC) clearance rates are predominantly derived from histological sampling or retrospective analyses. Prospective evaluations of clinical clearance remain limited. This study prospectively assessed long-term clinical clearance and scar outcomes following treatment of BCC with a 1064 nm Nd:YAG laser.
Methods: A total of 34 BCC lesions were treated using a 1064 nm Nd:YAG laser and evaluated at approximately 6 and 12 months post-treatment. Each follow-up included assessment for clinical evidence of recurrence and scar evaluation using the Patient and Observer Scar Assessment Scale (POSAS; range 6 = normal skin to 60 = severe scarring) which is a standardized scale.
Results: Twenty-two patients with 34 BCC tumors completed the study. Patients selected laser therapy primarily due to concerns regarding surgical downtime, cosmetic considerations, prior surgical burden, or poor surgical candidacy. Clinical recurrence was identified in one tumor at 6 months, with no additional recurrences observed at 12 months.
Conclusions: At 6 months, 97% of tumors (33/34) demonstrated clinical clearance, and all 33 tumors remained free of recurrence at 12 months. Scar outcomes were favorable, with mean POSAS patient and observer scores of 2.96 and 3.8 (on a 10-point scale), respectively. The 1064 nm Nd:YAG laser represents a promising, cosmetically favorable, and minimally invasive therapeutic option for BCC, particularly in patients who are suboptimal surgical candidates or who prefer non-surgical interventions.
{"title":"Prospective Outcomes After 1064 nm Nd:YAG Laser Treatment of Basal Cell Carcinoma.","authors":"Jusleen Ahluwalia, Amanda F Marsch, Kayla Zafar, Sara E Garrido, Arisa E Ortiz","doi":"10.1002/lsm.70106","DOIUrl":"https://doi.org/10.1002/lsm.70106","url":null,"abstract":"<p><strong>Background: </strong>Existing data on basal cell carcinoma (BCC) clearance rates are predominantly derived from histological sampling or retrospective analyses. Prospective evaluations of clinical clearance remain limited. This study prospectively assessed long-term clinical clearance and scar outcomes following treatment of BCC with a 1064 nm Nd:YAG laser.</p><p><strong>Methods: </strong>A total of 34 BCC lesions were treated using a 1064 nm Nd:YAG laser and evaluated at approximately 6 and 12 months post-treatment. Each follow-up included assessment for clinical evidence of recurrence and scar evaluation using the Patient and Observer Scar Assessment Scale (POSAS; range 6 = normal skin to 60 = severe scarring) which is a standardized scale.</p><p><strong>Results: </strong>Twenty-two patients with 34 BCC tumors completed the study. Patients selected laser therapy primarily due to concerns regarding surgical downtime, cosmetic considerations, prior surgical burden, or poor surgical candidacy. Clinical recurrence was identified in one tumor at 6 months, with no additional recurrences observed at 12 months.</p><p><strong>Conclusions: </strong>At 6 months, 97% of tumors (33/34) demonstrated clinical clearance, and all 33 tumors remained free of recurrence at 12 months. Scar outcomes were favorable, with mean POSAS patient and observer scores of 2.96 and 3.8 (on a 10-point scale), respectively. The 1064 nm Nd:YAG laser represents a promising, cosmetically favorable, and minimally invasive therapeutic option for BCC, particularly in patients who are suboptimal surgical candidates or who prefer non-surgical interventions.</p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cover micrograph: The cover image is based on the article Decoding the Mechanisms of Pigment Reduction and Skin Rejuvenation Induced by Picosecond Laser: Insights From a Porcine Model by Hao Wang et al., https://doi.org/10.1002/lsm.70084.
{"title":"Cover Image: Volume 58 Issue 2","authors":"Hao Wang, Xinyi Li, Yidan Xu, Huimiao Tang, Wanxin Zeng, Xiang Wen","doi":"10.1002/lsm.70112","DOIUrl":"https://doi.org/10.1002/lsm.70112","url":null,"abstract":"<p>Cover micrograph: The cover image is based on the article Decoding the Mechanisms of Pigment Reduction and Skin Rejuvenation Induced by Picosecond Laser: Insights From a Porcine Model by Hao Wang et al., https://doi.org/10.1002/lsm.70084.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146217240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel Sally, Lisa Akintilo, Marleigh Stern, Benjamin A Levinson, Kristen Lo Sicco, Daniel Gutierrez, Nayoung Lee
<p><strong>Background: </strong>Keloids are common in genetically predisposed individuals and in darker skin types, and treatment is especially challenging; the most commonly used therapeutic options return inconsistent results and often result in recurrence. Despite their prevalence and therapeutic challenges, keloids remain understudied and are often conflated with hypertrophic scars in the literature, though these conditions likely have distinct biomechanical etiologies. There remains a need for better optimization and comparison of existing treatment modalities to more effectively manage keloidal scarring.</p><p><strong>Methods: </strong>Thirteen patients with two similar keloids or one large keloid completed four treatments of a fractionally ablative erbium YAG laser, followed by application of either triamcinolone 10 mg/mL solution to one keloid or one half of the keloid or 5-fluorouracil solution 50 mg/mL solution to the second keloid or the other half of the keloid. Photos and measurements of the keloids were taken at each visit. The Patient and Observer Scar Assessment Scale (POSAS) score was recorded by the participants and the blinded physician observer at each visit. Blinded dermatologist observers completed the Hamilton score based on the scar photographs.</p><p><strong>Results: </strong>The overall POSAS scores improved after four treatments compared to the pre-treatment POSAS scores within both the TAC and 5-FU treatment arms. There was, however, no statistically significant difference in the change from the first to the final POSAS score between the arms (p = 0.53). There was also no statistically significant difference in the Hamilton Score at the final visit between the two arms (p = 0.30). Scar volume and surface area decreased in both arms. The 5-FU arm had a mean volumetric change from baseline of -368.7 cm<sup>3</sup>, and the TAC arm had a mean volumetric change from baseline of -310.7 cm<sup>3</sup>; there was not a statistically significant difference between the two (p = 0.06). The 5-FU arm had a mean surface area change from baseline of -38.3 cm<sup>2</sup>, and the TAC arm had a mean surface area change from baseline of -20.8 cm<sup>2</sup>; there was not a statistically significant difference between the two (p = 0.56). Ten out of 13 patients were Fitzpatrick skin types IV-VI. There were no serious adverse events reported.</p><p><strong>Conclusion: </strong>In this pilot study of keloid patients, POSAS scores significantly improved after both laser-assisted TAC delivery and laser-assisted 5-FU delivery, with no statistically significant difference between the two treatment arms. However, there was a noted discrepancy in patient reports of post-procedural hyperpigmentation, with more patients experiencing this adverse effect within the 5-FU arm than in the TAC arm. While fractionally ablative laser-assisted drug delivery with either 5-FU or TAC is a safe and effective method to treat keloids, special attention should b
{"title":"A Prospective Single-Subject Triple-Blinded Single-Center Pilot Study of Laser-Assisted 5-Fluorouracil Versus Laser-Assisted Corticosteroid Treatment for Keloids.","authors":"Rachel Sally, Lisa Akintilo, Marleigh Stern, Benjamin A Levinson, Kristen Lo Sicco, Daniel Gutierrez, Nayoung Lee","doi":"10.1002/lsm.70110","DOIUrl":"https://doi.org/10.1002/lsm.70110","url":null,"abstract":"<p><strong>Background: </strong>Keloids are common in genetically predisposed individuals and in darker skin types, and treatment is especially challenging; the most commonly used therapeutic options return inconsistent results and often result in recurrence. Despite their prevalence and therapeutic challenges, keloids remain understudied and are often conflated with hypertrophic scars in the literature, though these conditions likely have distinct biomechanical etiologies. There remains a need for better optimization and comparison of existing treatment modalities to more effectively manage keloidal scarring.</p><p><strong>Methods: </strong>Thirteen patients with two similar keloids or one large keloid completed four treatments of a fractionally ablative erbium YAG laser, followed by application of either triamcinolone 10 mg/mL solution to one keloid or one half of the keloid or 5-fluorouracil solution 50 mg/mL solution to the second keloid or the other half of the keloid. Photos and measurements of the keloids were taken at each visit. The Patient and Observer Scar Assessment Scale (POSAS) score was recorded by the participants and the blinded physician observer at each visit. Blinded dermatologist observers completed the Hamilton score based on the scar photographs.</p><p><strong>Results: </strong>The overall POSAS scores improved after four treatments compared to the pre-treatment POSAS scores within both the TAC and 5-FU treatment arms. There was, however, no statistically significant difference in the change from the first to the final POSAS score between the arms (p = 0.53). There was also no statistically significant difference in the Hamilton Score at the final visit between the two arms (p = 0.30). Scar volume and surface area decreased in both arms. The 5-FU arm had a mean volumetric change from baseline of -368.7 cm<sup>3</sup>, and the TAC arm had a mean volumetric change from baseline of -310.7 cm<sup>3</sup>; there was not a statistically significant difference between the two (p = 0.06). The 5-FU arm had a mean surface area change from baseline of -38.3 cm<sup>2</sup>, and the TAC arm had a mean surface area change from baseline of -20.8 cm<sup>2</sup>; there was not a statistically significant difference between the two (p = 0.56). Ten out of 13 patients were Fitzpatrick skin types IV-VI. There were no serious adverse events reported.</p><p><strong>Conclusion: </strong>In this pilot study of keloid patients, POSAS scores significantly improved after both laser-assisted TAC delivery and laser-assisted 5-FU delivery, with no statistically significant difference between the two treatment arms. However, there was a noted discrepancy in patient reports of post-procedural hyperpigmentation, with more patients experiencing this adverse effect within the 5-FU arm than in the TAC arm. While fractionally ablative laser-assisted drug delivery with either 5-FU or TAC is a safe and effective method to treat keloids, special attention should b","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To objectively quantify early and mid-term facial tightening after dual-wavelength Er:YAG/Nd:YAG laser treatment in Chinese women using three-dimensional (3D) imaging.
Materials and Methods
In this prospective observational study, 13 women with lower facial aging underwent four full-face treatment sessions of dual-wavelength Er:YAG/Nd:YAG (Fotona 4D) at 1-month intervals. Standardized 3D facial images were obtained at baseline and at 1 week, 1, 3, and 6 months after completion of the final treatment session. The primary objective outcomes were vertical displacements (mm) of predefined periocular and midfacial landmarks relative to baseline. Secondary outcomes included Wrinkle Severity Rating Scale (WSRS) scores for nasolabial folds and VISIA pore scores, evaluated at baseline and at 3 and 6 months. Adverse events were recorded.
Results
3D analysis demonstrated significant early and mid-term tightening in the lateral periorbital region. The vertical distance from the lateral canthus to the nasal base decreased by approximately 0.50–0.63 mm at 1 week and by 0.60–0.63 mm at 3 months bilaterally (all p < 0.05), with partial rebound but persistence of mild improvement at 6 months. The highest point of the zygomatic bone showed a delayed, mild elevation that peaked around 1–3 months. WSRS scores for nasolabial folds decreased by about 1 grade at 3 and 6 months on both sides (all p < 0.001). VISIA pore scores improved from 4.97 ± 0.36 at baseline to 3.37 ± 0.43 at 3 months and 3.73 ± 0.54 at 6 months (both p < 0.001). Only transient erythema and edema were observed.
Conclusions
Dual-wavelength Er:YAG/Nd:YAG laser tightening produced early and mid-term improvements in periocular and midfacial laxity, as captured by 3D landmark displacement, with concomitant improvements in wrinkles and pores. 3D imaging provides a sensitive, objective tool to visualize region-specific dynamic responses to energy-based facial rejuvenation.
{"title":"Three-Dimensional Imaging of Dynamic Changes After Nd:YAG/Er:YAG Laser Skin Tightening: A Prospective Study","authors":"Jun Qi, Qixuan Wang, Lvping Huang, Ling Zhang","doi":"10.1002/lsm.70095","DOIUrl":"10.1002/lsm.70095","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To objectively quantify early and mid-term facial tightening after dual-wavelength Er:YAG/Nd:YAG laser treatment in Chinese women using three-dimensional (3D) imaging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this prospective observational study, 13 women with lower facial aging underwent four full-face treatment sessions of dual-wavelength Er:YAG/Nd:YAG (Fotona 4D) at 1-month intervals. Standardized 3D facial images were obtained at baseline and at 1 week, 1, 3, and 6 months after completion of the final treatment session. The primary objective outcomes were vertical displacements (mm) of predefined periocular and midfacial landmarks relative to baseline. Secondary outcomes included Wrinkle Severity Rating Scale (WSRS) scores for nasolabial folds and VISIA pore scores, evaluated at baseline and at 3 and 6 months. Adverse events were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>3D analysis demonstrated significant early and mid-term tightening in the lateral periorbital region. The vertical distance from the lateral canthus to the nasal base decreased by approximately 0.50–0.63 mm at 1 week and by 0.60–0.63 mm at 3 months bilaterally (all <i>p</i> < 0.05), with partial rebound but persistence of mild improvement at 6 months. The highest point of the zygomatic bone showed a delayed, mild elevation that peaked around 1–3 months. WSRS scores for nasolabial folds decreased by about 1 grade at 3 and 6 months on both sides (all <i>p</i> < 0.001). VISIA pore scores improved from 4.97 ± 0.36 at baseline to 3.37 ± 0.43 at 3 months and 3.73 ± 0.54 at 6 months (both <i>p</i> < 0.001). Only transient erythema and edema were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dual-wavelength Er:YAG/Nd:YAG laser tightening produced early and mid-term improvements in periocular and midfacial laxity, as captured by 3D landmark displacement, with concomitant improvements in wrinkles and pores. 3D imaging provides a sensitive, objective tool to visualize region-specific dynamic responses to energy-based facial rejuvenation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"113-119"},"PeriodicalIF":1.9,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145863305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suzanne L. Kilmer, Mathew Avram, Ashish C. Bhatia, Nicole Y. Lee, Abby Jacobson
Objectives
To summarize the scientific rationale for the use of the monopolar radiofrequency tissue tightening system (monoRF) for the prevention of dermal aging (termed prejuvenation).
Materials and Methods
This narrative review summarizes the basic science of dermal aging and monoRF-induced collagen remodeling and neocollagenesis. Studies supporting the mechanism of action of monoRF treatment and its use for prejuvenation are reviewed.
Results
Dermal aging is largely attributed to the accumulation of fragmented collagen and depleted collagen levels. Collagen remodeling and neocollagenesis may be induced by monoRF treatment, resulting in immediate tissue tightening and subsequent collagen production, respectively. Preliminary data and expert opinion suggest that early and repeated intervention with monoRF may prevent progressive skin laxity via synergistic and cumulative effects.
Conclusions
MonoRF treatment shows potential as a prejuvenation strategy, with preliminary evidence supporting that it induces collagen remodeling and neocollagenesis. Future research should focus on long-term, prospective studies to determine the preventive benefits of consistent annual treatment for aging.
{"title":"Monopolar Radiofrequency for Dermal Prejuvenation: Scientific Rationale and Mechanisms of Action","authors":"Suzanne L. Kilmer, Mathew Avram, Ashish C. Bhatia, Nicole Y. Lee, Abby Jacobson","doi":"10.1002/lsm.70087","DOIUrl":"10.1002/lsm.70087","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To summarize the scientific rationale for the use of the monopolar radiofrequency tissue tightening system (monoRF) for the prevention of dermal aging (termed prejuvenation).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This narrative review summarizes the basic science of dermal aging and monoRF-induced collagen remodeling and neocollagenesis. Studies supporting the mechanism of action of monoRF treatment and its use for prejuvenation are reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Dermal aging is largely attributed to the accumulation of fragmented collagen and depleted collagen levels. Collagen remodeling and neocollagenesis may be induced by monoRF treatment, resulting in immediate tissue tightening and subsequent collagen production, respectively. Preliminary data and expert opinion suggest that early and repeated intervention with monoRF may prevent progressive skin laxity via synergistic and cumulative effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MonoRF treatment shows potential as a prejuvenation strategy, with preliminary evidence supporting that it induces collagen remodeling and neocollagenesis. Future research should focus on long-term, prospective studies to determine the preventive benefits of consistent annual treatment for aging.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"63-69"},"PeriodicalIF":1.9,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juliana Cristina Oliverio de Araújo, Hermano Camelo Paiva, Paula Margarida Meyer Faara, Og Fray Junior, Martha Simões Ribeiro
Background
Human papillomavirus (HPV) infections are a major cause of oral lesions, and in individuals living with HIV, lesions such as focal epithelial hyperplasia (FEH) may persist or exhibit atypical features, potentially progressing to more severe conditions if untreated. Managing oral HPV lesions in immunocompromised patients is challenging, as conventional therapies may carry higher risks or show limited efficacy.
Methods
This study reports the case of a 49-year-old HIV-positive male with valve disease and arthritis, requiring crutches for mobility. He presented with multiple painless oral lesions, diagnosed as FEH associated with oral HPV, and had previously undergone unsuccessful treatments. Photodynamic therapy (PDT) using methylene blue (MB) and a red laser was proposed as a treatment.
Results
Topical MB-mediated PDT successfully cleared the FEH lesions, with no recurrence observed over 24 months.
Conclusion
PDT mediated by MB is an effective and affordable approach for treating FEH associated with HPV in immunosuppressed patients, offering favorable outcomes and improved quality of life.
{"title":"Long-Term Control of Human Papillomavirus-Related Focal Epithelial Hyperplasia in an Human Immunodeficiency Virus-Positive Patient Using Methylene Blue-Mediated Photodynamic Therapy. A Case Report","authors":"Juliana Cristina Oliverio de Araújo, Hermano Camelo Paiva, Paula Margarida Meyer Faara, Og Fray Junior, Martha Simões Ribeiro","doi":"10.1002/lsm.70091","DOIUrl":"10.1002/lsm.70091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Human papillomavirus (HPV) infections are a major cause of oral lesions, and in individuals living with HIV, lesions such as focal epithelial hyperplasia (FEH) may persist or exhibit atypical features, potentially progressing to more severe conditions if untreated. Managing oral HPV lesions in immunocompromised patients is challenging, as conventional therapies may carry higher risks or show limited efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study reports the case of a 49-year-old HIV-positive male with valve disease and arthritis, requiring crutches for mobility. He presented with multiple painless oral lesions, diagnosed as FEH associated with oral HPV, and had previously undergone unsuccessful treatments. Photodynamic therapy (PDT) using methylene blue (MB) and a red laser was proposed as a treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Topical MB-mediated PDT successfully cleared the FEH lesions, with no recurrence observed over 24 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PDT mediated by MB is an effective and affordable approach for treating FEH associated with HPV in immunosuppressed patients, offering favorable outcomes and improved quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"70-73"},"PeriodicalIF":1.9,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/lsm.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paulus Anthony Halim, Sondang P. Sirait, Larisa Paramitha Wibawa, Shannaz Nadia Yusharyahya, Michael Sie Shun Ling
Objective
Lichen sclerosus (LS) is a chronic inflammatory dermatosis that predominantly affects the genital region, but can also manifest in other areas of the body. Extragenital LS is often less responsive to standard treatments, necessitating alternative modalities. Herein, we describe the case of a young adult man with a 7-year history of an enlarging sclerotic plaque on the right thigh, refractory to high-potency topical corticosteroids and intralesional triamcinolone.
Methods
The patient underwent three sessions of fractional CO2 laser combined with platelet-rich plasma (PRP) therapy over 6 months. Pre- and post-treatment biopsies were performed to investigate histologic changes associated with the healing response.
Results
The treatment resulted in near-complete flattening of the plaque and resolution of dermal sclerosis. A post-treatment biopsy confirmed diminished collagen hyalinization, restoration of elastic fibers, and increased fibroblasts and neovascularization. No recurrence was observed at 1-year follow-up.
Conclusion
This case highlights the potential role of fractional CO2 laser combined with PRP as an effective therapeutic option for recalcitrant extragenital LS. Further studies are warranted to validate this combined approach.
{"title":"Successful Treatment of Recalcitrant Extragenital Lichen Sclerosus With Fractional CO2 Laser and Platelet-Rich Plasma: A Case Report With Histologic Evaluation","authors":"Paulus Anthony Halim, Sondang P. Sirait, Larisa Paramitha Wibawa, Shannaz Nadia Yusharyahya, Michael Sie Shun Ling","doi":"10.1002/lsm.70093","DOIUrl":"10.1002/lsm.70093","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Lichen sclerosus (LS) is a chronic inflammatory dermatosis that predominantly affects the genital region, but can also manifest in other areas of the body. Extragenital LS is often less responsive to standard treatments, necessitating alternative modalities. Herein, we describe the case of a young adult man with a 7-year history of an enlarging sclerotic plaque on the right thigh, refractory to high-potency topical corticosteroids and intralesional triamcinolone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The patient underwent three sessions of fractional CO<sub>2</sub> laser combined with platelet-rich plasma (PRP) therapy over 6 months. Pre- and post-treatment biopsies were performed to investigate histologic changes associated with the healing response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The treatment resulted in near-complete flattening of the plaque and resolution of dermal sclerosis. A post-treatment biopsy confirmed diminished collagen hyalinization, restoration of elastic fibers, and increased fibroblasts and neovascularization. No recurrence was observed at 1-year follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights the potential role of fractional CO<sub>2</sub> laser combined with PRP as an effective therapeutic option for recalcitrant extragenital LS. Further studies are warranted to validate this combined approach.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 2","pages":"74-78"},"PeriodicalIF":1.9,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To explore the related influencing factors of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) for port-wine stain(PWS) and evaluate the relationship between dermoscopic vascular patterns and treatment efficacy.
Methods
Retrospective analysis of 182 PWS patients (November 2017 to November 2023) who received HMME-PDT. Among them, 51 patients had dermoscopy before treatment. Demographic (age, gender), clinical (lesion location, colors, size, treatments), and dermoscopic data (vascular patterns) were collected. Efficacy was assessed via pre-/post-treatment photos (classified as complete regression, good improvement, slight improvement, or no improvement), and adverse reactions were recorded. SPSS 26.0 was used for statistical analysis.
Results
Among 182 PWS patients, HMME-PDT achieved an overall response rate of 77.5% (141/182), with 23.6% (43) showing complete regression, 15.9% (29) demonstrating good improvement, and 37.9% (69) experiencing slight improvement; 22.5% (41) showed no improvement. Efficacy significantly correlated with age, lesion location, color, size, and treatments (p < 0.05), but not with gender or facial partition (V1, V2, V3) (p > 0.05). Multivariate analysis identified small lesion size, facial and neck, pink and purplish red lesions as positive predictors, while fewer treatment sessions were unfavorable. Seven cases (3.85%) developed long-term adverse effects (5 scars, 2 hyperpigmentations). Dermoscopic analysis of 51 vascular patterns revealed significant efficacy differences among pattern types (p < 0.05), with type I (23.5%), type II (43.2%), and type III (29.4%) showing distinct therapeutic responses.
Conclusion
HMME-PDT efficacy correlates with age, lesion location, color, size, and treatments, but not gender and facial partition (V1, V2, V3). Dermoscopic vascular patterns can predict treatment response, with type I being the most effective.
{"title":"Clinical Efficacy Analysis of Hematoporphyrin Monomethyl Ether Photodynamic Therapy for Port-Wine Stain","authors":"Minghui Li, Yang Song, Yao Chen, Junfeng Zhou","doi":"10.1002/lsm.70090","DOIUrl":"10.1002/lsm.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To explore the related influencing factors of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) for port-wine stain(PWS) and evaluate the relationship between dermoscopic vascular patterns and treatment efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective analysis of 182 PWS patients (November 2017 to November 2023) who received HMME-PDT. Among them, 51 patients had dermoscopy before treatment. Demographic (age, gender), clinical (lesion location, colors, size, treatments), and dermoscopic data (vascular patterns) were collected. Efficacy was assessed via pre-/post-treatment photos (classified as complete regression, good improvement, slight improvement, or no improvement), and adverse reactions were recorded. SPSS 26.0 was used for statistical analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 182 PWS patients, HMME-PDT achieved an overall response rate of 77.5% (141/182), with 23.6% (43) showing complete regression, 15.9% (29) demonstrating good improvement, and 37.9% (69) experiencing slight improvement; 22.5% (41) showed no improvement. Efficacy significantly correlated with age, lesion location, color, size, and treatments (<i>p</i> < 0.05), but not with gender or facial partition (V1, V2, V3) (<i>p</i> > 0.05). Multivariate analysis identified small lesion size, facial and neck, pink and purplish red lesions as positive predictors, while fewer treatment sessions were unfavorable. Seven cases (3.85%) developed long-term adverse effects (5 scars, 2 hyperpigmentations). Dermoscopic analysis of 51 vascular patterns revealed significant efficacy differences among pattern types (<i>p</i> < 0.05), with type I (23.5%), type II (43.2%), and type III (29.4%) showing distinct therapeutic responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>HMME-PDT efficacy correlates with age, lesion location, color, size, and treatments, but not gender and facial partition (V1, V2, V3). Dermoscopic vascular patterns can predict treatment response, with type I being the most effective.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"58 1","pages":"49-56"},"PeriodicalIF":1.9,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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