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2010 15th National Biomedical Engineering Meeting最新文献

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Investigation of Escherichia Coli bacteria growth process using electronic nose 电子鼻对大肠杆菌生长过程的研究
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479822
Mehmet Sahin, Hamdi Melih Saraoglu
In this study, the kind of Escherichia Coli obtained using gas sensor sequence consisted deneyler QCM (Quartz Crystal Microbalance) as experiments related to determining from the odour of growing duration of the bacteria. In this context, the growing duration of odour produced by Escherichia Coli bacteria was examined in five day period after 24, 48, 72, 96, 120 hours that they were planted in petridish. The evaluation of odour data was carried out using the method of Principle Component Analysis (PCA). It was found that the kind of Escherichia Col, bacteria can be identified clearly after 24 hours and partially after 48 hours that they are planted in petridish.
在本研究中,使用气体传感器序列获得的大肠杆菌种类包括deneyler QCM(石英晶体微天平)作为从气味确定细菌生长持续时间的相关实验。在这种情况下,在培养皿中种植24、48、72、96、120小时后的5天内,研究了大肠杆菌产生气味的持续时间。采用主成分分析(PCA)方法对气味数据进行评价。结果表明,在培养皿中培养24小时后可明确鉴定大肠杆菌的种类,培养48小时后可部分鉴定。
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引用次数: 0
Accurate segmentation of the breast region with texture filter in mammograms for CAD applications 基于纹理滤波器的乳腺区域精确分割
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479843
Pelin Kus, I. Karagöz
The first and one of the most important preprocessing steps of the mammogram analysis is segmentation of the breast region. Accurate detection of breast tissue-air line allows focusing on ROI in cancer investigation, by detecting architectural distortion at the border, determination of the retraction location at the cancerous region under skin and, reducing the storage needs in PACS. The structural differences of the breast tissue itself, the variations in breast position, orientation, amount of compression and device characteristics in image acquisitions taken in different times, makes breast segmentation process challenging. In this study, by proposed texture filter method, above 99% value is achieved in completeness, accuracy and quality parameters.
乳房x光片分析的第一步也是最重要的预处理步骤之一是乳房区域的分割。准确检测乳腺组织-空气线,通过检测边界的结构扭曲,确定皮肤下癌变区域的缩回位置,减少PACS中的存储需求,从而可以专注于癌症调查的ROI。乳房组织本身的结构差异,以及不同时间图像采集中乳房位置、方向、压缩量和设备特性的变化,使得乳房分割过程具有挑战性。在本研究中,本文提出的纹理滤波方法在完整性、精度和质量参数上均达到99%以上。
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引用次数: 3
Mapping of the visual cortex: A Freesurfer™-based approach 视觉皮层的映射:一个基于Freesurfer™的方法
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479759
Meltem Yorulmaz, E. Karahan, A. Hamamci, Cengizhan Öztürk
Retinotopy is a tool for mapping of the visual cortex which provides detailed information about the correspondence between the visual field and its cortical representation in the visual subject. Therefore, the studies about retinotopic mapping is increasing rapidly as a branch of neuro science. Our study includes three main parts: The first one is the acquiring the data. While subject is stimulated with flickering and slowly moving checkerboard, data are acquired with 3T MR machine. In the second part, analysis part, data are analyzed and visualized with Freesurfer™. Since the procedures on Freesurfer™ are complicated and depends on high technical information, in the third part, we create a MATLAB™-based GUI to make these processes simpler.
视网膜切除是一种视觉皮层映射的工具,它提供了视觉主体视野与其皮层表征之间对应关系的详细信息。因此,作为神经科学的一个分支,视网膜定位的研究正在迅速发展。我们的研究主要包括三个部分:第一部分是数据的获取。当受试者受到闪烁和缓慢移动的棋盘刺激时,3T核磁共振机采集数据。在第二部分,分析部分,使用Freesurfer™对数据进行分析和可视化。由于Freesurfer™上的程序是复杂的,并且依赖于高技术信息,在第三部分中,我们创建了一个基于MATLAB™的GUI,使这些过程更简单。
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引用次数: 0
Removal of brain tissue by Tm-fiber laser tm光纤激光切除脑组织
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479794
B. Tunç, M. Gülsoy
The aim of the study was to investigate the thermal effects of the 1940-nm Tm-fiber laser on the dead brain tissue. 4-5 mm coronal sections were taken from lamb brains. Tm-fiber laser was applied at the back (cortical) and below the cortex (subcortical) of these slices with 0.5 mm distance. At the beginning of the research in order to find appropriate laser parameter to be compared for 1940-nm Tm-fiber laser, the carbonization and coagulation times of the brain slices were recorded for each power value, both for cortical and subcortical tissue. The appropriate laser parameters for lamb brain tissue were selected according to this study. Lasers were applied in both continuous and pulsed modes. In continuous mode, doses were changed with fixed application time. In pulsed mode, doses were modified with the change in pulse width. The lesions were detected with microscope. The radius of ablation and coagulation for each laser application was recorded. By calculating ablation efficiency (100× ablation/calculation radius) the appropriate laser doses were determined for both cortical and subcortical tissue. The maximum ablation efficiency for cortical tissue in continuous mode was 200 mW and 600 mW and in pulsed mode was 600 mW and for subcortical tissue maximum ablation efficiency was found 600 mW in both continuous mode and pulsed mode.
这项研究的目的是研究4040nm tm光纤激光对死亡脑组织的热效应。取羊脑4 ~ 5mm冠状面切片。在这些切片的背面(皮质)和皮层下方(皮质下)以0.5 mm的距离应用tm光纤激光。在研究开始时,为了找到适合1940-nm tm光纤激光器的激光参数进行比较,我们记录了大脑皮层和皮层下组织在每个功率值下的碳化和凝固时间。在此基础上,选择了适合羔羊脑组织的激光参数。激光以连续和脉冲两种方式应用。在连续模式下,剂量随施用时间的固定而改变。在脉冲模式下,剂量随脉冲宽度的变化而变化。显微镜下观察病变。记录每次激光应用的消融和凝固半径。通过计算消融效率(100×消融/计算半径)确定皮质和皮质下组织的合适激光剂量。连续模式下皮质组织的最大消融效率为200 mW和600 mW,脉冲模式下皮质组织的最大消融效率为600 mW,连续模式和脉冲模式下皮质组织的最大消融效率均为600 mW。
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引用次数: 0
Evaluation of brain hemodynamics with functional near infrared spectroscopy during head-down tilt on young and healthy subjects 用近红外光谱评价年轻健康受试者头向下倾斜时的脑血流动力学
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479807
M. Alptekin, A. Akın
Human brain undergoes a number of physiological changes. Especially these changes contributes to optical properties of brain and can be observed with optical imaging methods in visible and near infrared light range. The aim of this study is, by using functional near infrared spectroscopy (fNIRS), with a specific protocol, observing oxygenation and blood volume with respect to time on young and healthy subjects. For this purpose, 5 healthy young male and 5 healthy young female are participated and measurements are taken from their prefrontal cortex during the experiment. When the subjects are in supine position, they are asked to move their heads down to their knees and stay in this position for 30 seconds. When this experiment is ended, oxygenation and blood volume changes were observed. fNIRS signals are analysed into two groups containing eight signals each and so they will represent the right and the left hemisphere of the brain. In each hemisphere, maximum and minimum points of blood volume showed no significant difference for male and female. (left hemisphere: Vmin p=0.25, Vmax p=0.12; right hemisphere: Vmin p=0.07, Vmax p=0.07). Without taking sex difference into account, Vmin ve Vmax values of right and left hemisphere are also not significantly different (respectively p=0.22, p=0.06). Therefore, this study implies that there is not a meaningful difference of brainhemodynamic responses during a head tilt test in adult subject group with respect to gender and laterality. fNIRS system hence possesses a potential to diagnose cerebrovascular diseases.
人的大脑经历了许多生理变化。特别是这些变化有助于大脑的光学特性,可以用可见光和近红外光范围内的光学成像方法观察到。本研究的目的是通过使用功能性近红外光谱(fNIRS),在特定的方案下,观察年轻健康受试者的氧合和血容量随时间的变化。为此,5名健康的年轻男性和5名健康的年轻女性参与了实验,并在实验期间从他们的前额叶皮层进行了测量。当受试者处于仰卧位时,他们被要求将头移到膝盖处,并保持该姿势30秒。实验结束后,观察氧合和血容量变化。fNIRS信号被分析成两组,每组包含8个信号,因此它们将代表大脑的左右半球。在各半球,男女血容量最大值和最小值无显著差异。(左半球:Vmin p=0.25, Vmax p=0.12;右半球:Vmin p=0.07, Vmax p=0.07)。在不考虑性别差异的情况下,左右半球的Vmin和Vmax值也无显著差异(p=0.22, p=0.06)。因此,本研究表明,在成人受试者的头部倾斜试验中,脑血流动力学反应在性别和偏侧方面没有显著差异。因此,fNIRS系统具有诊断脑血管疾病的潜力。
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引用次数: 0
Tele-health monitoring platform 远程健康监测平台
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479732
Birgul Kutlu, Alp Kut, Meltem Yıldırım
The aim of the study is to design a platform for tele-health monitoring system. This system will achieve the vital signs, such as blood pressure, body temperature, heart rate or blood oxygen, of patients, who need to be continuously monitored, with medical devices. This device will transmit the data to a clinical center using Internet. The data will be monitored through a web interface, necessary reports will be prepared according to the analysis of data and 3rd parties will be informed in case of emergency situations. After the development of the platform a preliminary work will be prepared in order to evaluate the system for the willingness of Turkish patients to use these kind of devices and improvement of health risk.
本课题的目的是设计一个远程健康监测系统平台。该系统将通过医疗设备实现对需要持续监测的患者的生命体征,如血压、体温、心率或血氧。该设备将通过互联网将数据传输到临床中心。数据将通过网络界面进行监测,根据数据分析编写必要的报告,并在紧急情况下通知第三方。在平台开发之后,将准备一项初步工作,以评估土耳其患者使用此类设备的意愿和改善健康风险的系统。
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引用次数: 0
Problems of biocompatibility from materials in knee arthroplasty 膝关节置换术中材料的生物相容性问题
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479765
G. Akdoğan, A. Güney
In this study, research has been conducted on the formation processes and causes of problems that have arisen over the long term from materials used in knee or hip arthroplasty patients. A rare case has been viewed for a patient who had arthroplasty ten years previously. During a second knee joint revision surgery after implant failure, a biopsy of bone and soft tissue taken from around the implant relevant deterioration caused by the materials used in the initial implant. Using several different technological laboratory methods, analysis of the removed implants and the adhesive materials between bone and implant; besides, the diffusion that occurred between them were examined. In addition, similar problems and research are reviewed in the literature that has been published about the subject. Because problems related to the materials used in knee and hip arthroplasty have arisen, more research is necessary to find appropriate solutions.
在这项研究中,研究了长期以来膝关节或髋关节置换术患者使用的材料所产生的问题的形成过程和原因。一个罕见的病例已被视为一个病人谁做了关节置换术十年前。在假体失败后的第二次膝关节翻修手术中,从假体周围采集的骨和软组织活检与最初假体使用的材料引起的恶化有关。采用几种不同的工艺实验室方法,对拔除的种植体及骨与种植体之间的黏附材料进行分析;此外,还研究了它们之间发生的扩散。此外,在已发表的关于该主题的文献中回顾了类似的问题和研究。由于膝关节和髋关节置换术中使用的材料出现了问题,需要更多的研究来找到合适的解决方案。
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引用次数: 1
Real time wireless monitoring of Ecg and Pcg signals at computer 在计算机上实时无线监测心电和心电图信号
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479827
U. Fidan, Naim Karasekreter, Gülin Ütebay
In this study, the signals of ECG and PCG are taken simultaneously in the clinical environment and are transferred wirelessly. With the prepared software the transferred data, which are displayed on the computer of the physician, will facilitate the comparison of the ECG and PCG formation and will also help the diagnosis of abnormalities in heart. In this system, there are two units called a transmitter and a receiver. The signals in the transmitter unit can be transferred to the computer by means of two-channel Data Acquisition Card (DAQ) in the receiver unit which digitized the signals via RF wireless transmission process and also can be displayed on the physician's computer with prepared 2-channel Data Imagining Software.
本研究在临床环境下同时采集心电图和PCG信号,并进行无线传输。通过编写的软件,将传输的数据显示在医生的电脑上,方便心电图和心电图的形成对比,也有助于心脏异常的诊断。在这个系统中,有两个单元称为发射机和接收机。发送单元中的信号通过接收单元中的双通道数据采集卡(DAQ)传输到计算机,接收单元通过射频无线传输过程将信号数字化,也可以通过准备好的双通道数据想象软件显示在医生的计算机上。
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引用次数: 0
Multimodal segmentation of brain MR images through hidden Markov random fields 基于隐马尔可夫随机场的脑磁共振图像多模态分割
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479876
Ufuk Mat, M. Ozkan
Segmentation of brain MR images, especially into three main tissue types: CSF, GM and WM is an essential task in clinical applications as it aids surgical planning, computer-aided nuerosurgery and diagnosis. However, every single MR image contains degenerative components such as noise and RF inhomogeneity which dramatically reduces the accuracy of the results of automatic post-processing techniques. A number of methods are proposed in the literature for tissue segmentation of brain MR images. Among these Otsu thresholding, ML estimation and MRF model based methods are the ones that widely used. Moreover, 2D segmentation of True-T1 and True-T2 images almost completely removes the artifacts mentioned above hence, results in the most successful outcomes ever reported. However, the required scan time of the method and the expence of the process makes it inapplicable to clinical practices. In this study, three different segmentation schemes for brain MR images, namely Otsu thresholding, ML classification and MRF model based segmentation are analyzed taking the segmentation results of 2D segmented true parameter images as golden standards and a novel multivariate HMRF segmentation method using T1 and T2-weighted images is proposed.
脑MR图像的分割,特别是三种主要的组织类型:CSF、GM和WM,是临床应用中的一项重要任务,因为它有助于手术计划、计算机辅助神经外科和诊断。然而,每一张磁共振图像都含有退化成分,如噪声和射频不均匀性,这大大降低了自动后处理技术结果的准确性。文献中提出了许多脑磁共振图像的组织分割方法。其中,Otsu阈值法、ML估计法和基于MRF模型的方法应用最为广泛。此外,对True-T1和True-T2图像的二维分割几乎完全消除了上述伪影,因此获得了有史以来最成功的结果。然而,该方法所需的扫描时间和过程的费用使其不适用于临床实践。本研究以二维真参数图像分割结果为金标准,分析了Otsu阈值分割、ML分类和基于MRF模型的三种脑MR图像分割方案,提出了一种基于T1和t2加权图像的多元HMRF分割新方法。
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引用次数: 0
Remote support and reporting system for advanced applications of magnetic resonance imaging 磁共振成像先进应用的远程支持和报告系统
Pub Date : 2010-04-21 DOI: 10.1109/BIYOMUT.2010.5479758
Engin Demirel, Onur Özyurt, Ertuğrul Akbaş, A. Dinçer, Cengizhan Öztürk
For advanced magnetic resonance imaging (MRI) applications, a support and reporting system that will connect technical and clinical research centers has been designed. System consists of workstation based on the clinical center, software installed on the workstation and research center's computer and installed software. Client / server architecture and TCP-IP using the image on the MR console screen to be transmitted in real time, developed the interface and the remote control protocols, workstation with computer research data transfer between the radiologist and the engineer / physicist, the written or voice communication and analysis of the results reporting practices were all developed so that the researchers are able to intervene indirectly to the MR protocol, view the resulting data or research on their workstation, automatically analyze data and DICOM structured reports (DICOM SR) preparation opportunities were created. Analysis using as input the results of functional MRI of the anatomical atlas were superimposed over the selected images and clinicians can create reports with DICOM SR and rich text file (rtf) on software tools that have been developed.
对于先进的磁共振成像(MRI)应用,已经设计了连接技术和临床研究中心的支持和报告系统。系统由基于临床中心的工作站、安装在工作站的软件和研究中心的计算机以及安装的软件组成。客户端/服务器架构和TCP-IP利用磁共振控制台屏幕上的图像进行实时传输,开发了接口和远程控制协议,工作站与放射科医生和工程师/物理学家之间的计算机研究数据传输,书面或语音通信和结果报告分析实践都被开发,以便研究人员能够间接干预磁共振协议。查看结果数据或在其工作站上进行研究,自动分析数据和DICOM结构化报告(DICOM SR)的准备机会被创建。将解剖图谱的功能MRI结果作为输入进行分析,并将其叠加在选定的图像上,临床医生可以在已开发的软件工具上使用DICOM SR和富文本文件(rtf)创建报告。
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引用次数: 0
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2010 15th National Biomedical Engineering Meeting
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