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RELIABILITY ANALYSIS OF ACTIVE REDUNDANT SYSTEM USING GEOMETRIC DISTRIBUTION 基于几何分布的有源冗余系统可靠性分析
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.7
Pankaj, J. Bhatti, M. Kakkar
The present paper is an initiative taken towards study and analysis of industries concerning different maintenance strategies towards their products on behalf of their working and maintenance level. The objective of presenting the concept of the dual nature of repair for units having extra or major failures in addition to regular ones is well explained. The stochastic analysis of reliability characteristics using regenerative techniques for the system consisting of two parallel units following the active-standby redundancy and having different repair time distributions was also studied using geometric distribution. The numerical equations and results are being evaluated for reliability parameters like mean time to system failure, availability of the system in operative form, down period of the system following repair mechanism using regenerative techniques, and geometric distribution. The graphical analysis has also been presented for-profit function with respect to repair and failure rate.
本论文旨在研究和分析行业对其产品的不同维护策略,代表其工作和维护水平。除了常规故障外,还存在额外或重大故障的机组,提出维修双重性质的概念的目的得到了很好的解释。采用几何分布方法研究了由两个并联单元组成的系统的可靠性特性的随机分析,该系统遵循主备冗余,具有不同的维修时间分布。正在评估数值方程和结果的可靠性参数,如系统故障的平均时间、运行状态下系统的可用性、使用再生技术的修复机制后系统的停机时间以及几何分布。图形分析还提出了关于修复率和故障率的营利性函数。
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引用次数: 0
PHOTOPROTECTIVE EFFECTS OF CARRAGEENANS AGAINST ULTRAVIOLETB-INDUCED EXTRACELLULAR MATRIX (ECM) DAMAGE IN KERATINOCYTES 角化细胞抗紫外线诱导的细胞外基质损伤的光保护作用
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.4
H. Thevanayagam, S. Mohamed, W. Chu, Z. Eshak
Carrageenans, the polysaccharide from red seaweeds is widely used in food, medicine and as an excipient in cosmetics and skincare products. Carrageenans have shown prospective photoprotective effect against ultraviolet B (UVB) irradiation on immortalised normal human keratinocyte (HaCaT) cells. The aim of this research was to evaluate the photoprotective effect of iota (ι), kappa (κ)-carrageenans and their combination with vitamin E against UVB-induced extracellular matrix (ECM) damage in HaCaT cells. The study also assessed the superoxide dismutase (SOD) and catalase (CAT) antioxidant enzymes in UVB exposed pre-treated and non-pre-treated cells. The parameters assessed were biological mediators important for the structural integrity of ECM, comprising of epidermal growth factor receptor (EGFR), mitogen-activated protein kinase (MAPK), activating protein- (AP-1) and matrix metalloproteinases (MMPs), liberated by the UVB exposed cells. Enzyme linked immunosorbent assay was used to evaluate the release of these mediators. Carrageenans enhanced the activities of the antioxidant enzymes SOD and CAT which acts as a defence mechanism against oxidative stress. The levels of the biological mediators were also reduced in cells pre-treated with carrageenans, suggesting that the polysaccharide has potential in maintaining the skin’s integrity by reducing the damage to ECM upon UVB exposure. Taken together, the results suggest that carrageenans do possess photoprotective effects against UVB-induced ECM damage and stimulates antioxidant enzymes.
卡拉胶是从红海藻中提取的多糖,广泛用于食品、医药以及化妆品和护肤品的辅料。卡拉胶对永生化的正常人角质形成细胞(HaCaT)具有抗紫外线B(UVB)照射的前瞻性光保护作用。本研究的目的是评估iota(ι)、kappa(κ)-卡拉胶及其与维生素E的组合对UVB诱导的HaCaT细胞胞外基质(ECM)损伤的光保护作用。该研究还评估了暴露于UVB的预处理和未预处理细胞中的超氧化物歧化酶(SOD)和过氧化氢酶(CAT)抗氧化酶。评估的参数是对ECM结构完整性重要的生物介质,包括表皮生长因子受体(EGFR)、丝裂原活化蛋白激酶(MAPK)、活化蛋白-(AP-1)和基质金属蛋白酶(MMPs),由暴露于UVB的细胞释放。酶联免疫吸附试验用于评估这些介质的释放。卡拉胶增强了抗氧化酶SOD和CAT的活性,这是对抗氧化应激的防御机制。在用卡拉胶预处理的细胞中,生物介质的水平也降低了,这表明多糖通过减少UVB暴露对ECM的损伤,在保持皮肤完整性方面具有潜力。总之,结果表明卡拉胶确实对UVB诱导的ECM损伤具有光保护作用,并刺激抗氧化酶。
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引用次数: 0
BIOAUTOGRAPHY, COMBINATION EFFECTS AND PHOTO-ACTIVATED ENZYMATIC RESTRICTION INHIBITORY ACTIVITY OF ANTIMICROBIAL ALKALOIDS FROM GLYCOSMIS 葡糖苷类抗菌生物碱的生物图谱、组合效应及光活化酶限制性抑制活性
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.1
Nurhaya Md Taib, N. Mohd Hassan, Laina Zarisa Mohd Kamal, M. Soe
Glycosmis pentaphylla (Retz.) DC., locally known as nerapan, has long been used in Asian countries as a traditional remedy for ailments attributed to microbial infections. This study aims to isolate antimicrobial alkaloids from G. pentaphylla, to determine their combination effects with selected antimicrobial agents and to screen for their photoactivated enzymatic restriction inhibitory activity. Bioautography-guided isolation of antimicrobial alkaloids was performed by using column chromatography with Staphylococcus aureus, Escherichia coli, and Candida albicans as the indicator microbes. The antimicrobial effects of the alkaloids combined with selected antimicrobial agents, namely, ciprofloxacin, erythromycin, vancomycin, and ketoconazole, were determined by using a checkerboard assay. Photoactivated enzymatic restriction inhibitory activity was assessed by using agarose gel electrophoresis. Two antimicrobial active alkaloids were isolated and identified as arborinine and arborine. The antimicrobial activity of arborinine and arborine was determined to be in the range of 250 µg/ml and 1000 µg/ml. Partial synergy was observed for all arborine-antibiotics and arborinine-ketoconazole interactions against S. aureus and C. albicans, respectively. Arborine was relatively the strongest photoactivated enzymatic restriction inhibitor, particularly against EcoRI, PstI, and SalI. The results obtained are promising and encourage further research on alkaloids as potential antimicrobial-enhancing agents.
绞股蓝(Glycosmis pentaphylla,Retz.)。,当地称为nerapan,长期以来在亚洲国家被用作治疗微生物感染疾病的传统药物。本研究旨在从绞股蓝中分离抗菌生物碱,测定其与所选抗菌剂的联合作用,并筛选其光活化酶限制性抑制活性。以金黄色葡萄球菌、大肠杆菌和白色念珠菌为指示菌,采用柱色谱法,在生物图谱引导下分离抗菌生物碱。采用棋盘格法测定了生物碱与选定的抗菌剂环丙沙星、红霉素、万古霉素和酮康唑的抗菌效果。利用琼脂糖凝胶电泳评价光活化酶限制性抑制活性。分离鉴定出两种具有抗菌活性的生物碱,分别为乔木碱和乔木碱。虫媒啉和虫媒啉的抗菌活性在250µg/ml和1000µg/ml范围内。观察到所有羧酸类抗生素和羧酸酮康唑相互作用分别对金黄色葡萄球菌和白色念珠菌产生部分协同作用。Arborine是相对最强的光活化酶限制性抑制剂,特别是对EcoRI、PstI和SalI。所获得的结果是有希望的,并鼓励进一步研究生物碱作为潜在的抗菌增强剂。
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引用次数: 0
THE MOLECULAR BEHAVIORS OF CALIXARENES AT THE AIR-WATER INTERFACE: DENSITY FUNCTIONAL THEORY, SURFACE PRESSURE, POTENTIAL, AND EFFECTIVE DIPOLE MOMENT 杯芳烃在空气-水界面的分子行为:密度泛函理论、表面压力、势和有效偶极矩
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.9
F. L. Supian, Wong Yeong Yi, Nur Farah Nadia Abd Karim, A. Radzwan, Darvina Lim Choo Kheng, A. A. Al Naim
This study examined the behaviors of Langmuir-Blodgett ultrathin calixarene films at the air-water interface. The Langmuir trough was used to estimate the surface pressure, surface potential, and effective dipole moment of two calixarenes, namely, calix[4]arene (THC4) and calix[8]arene (THC8). The band gap was determined using the density functional theory (DFT). The DFT simulation gave a band gap of 2.28 eV for THC4, confirming that THC4 was an insulator. The surface pressure isotherms of THC4 and THC8 yielded the expected molecular behavior from the gaseous to the solid phases. THC4 and THC8 showed a perpendicular and a parallel orientation in the air-water subphase, respectively. The ∆Vmax values of TCH4 and THC 8 were 205 mV and 141mV, respectively, and their µ﬩max values were 0.147 D and 0.088 D, respectively.
本文研究了Langmuir-Blodgett超薄杯芳烃薄膜在空气-水界面上的行为。利用Langmuir槽估计了杯芳烃(THC4)和杯芳烃(THC8)的表面压力、表面电位和有效偶极矩。利用密度泛函理论(DFT)确定了带隙。DFT模拟得到THC4的带隙为2.28 eV,证实THC4是绝缘体。THC4和THC8的表面压力等温线得到了从气相到固相的预期分子行为。THC4和THC8在气-水亚相中分别呈垂直和平行方向。TCH4和THC 8的∆Vmax值分别为205 mV和141mV,µ﬩max值分别为0.147 D和0.088 D。
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引用次数: 0
MORTALITY PREDICTION OF SURGICAL INTENSIVE CARE UNIT PATIENTS USING DEEP LEARNING-BASED SURVIVAL MODELS 基于深度学习的生存模型的外科重症监护病房患者死亡率预测
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.6
L. M.K., S. Acharya, A. Kamath, D. Micheal
Mortality prediction in surgical intensive care units (SICUs) is considered to be among the most critical steps in enforcing efficient treatment policies. This study aims to evaluate the performance of various deep learning models in predicting the mortality of patients admitted to SICUs. The survival of 2,225 adult patients admitted to SICUs was modeled using five salient deep learning-based survival models, namely, Cox-CC, Cox-Time, DeepSurv, DeepHit, and N-MTLR. The data were extracted from the Medical Information Mart for Intensive Care II (MIMIC-II) database. The performance of the models was compared using the time-dependent concordance index (Ctd-index) and integrated Brier score (IBS). From among the five models, DeepSurv achieved the most accurate prediction, while Cox-Time demonstrated the least optimal predictive ability. For DeepSurv, Cox-CC, DeepHit, N-MTLR, and Cox-Time, the mean Ctd -index was 0.773, 0.767, 0.765, 0.732, and 0.659, and the mean IBS was 0.181, 0.192, 0.195, 0.212, and 0.225, respectively. DeepSurv, Cox-CC, and DeepHit yielded comparable performance. Deep learning models are free from the stringent assumptions inherent in standard survival models. Hence, these models are considered flexible alternatives to the standard approaches in scalable, real-world survival problems.
外科重症监护室(SICU)的死亡率预测被认为是执行有效治疗政策的最关键步骤之一。本研究旨在评估各种深度学习模型在预测SICU患者死亡率方面的性能。使用五个显著的基于深度学习的生存模型,即Cox-CC、Cox-Time、DeepSurv、DeepHit和N-MTLR,对2225名入住SICU的成年患者的生存进行建模。这些数据是从重症监护医学信息集市II(MIMIC-II)数据库中提取的。使用时间依赖一致性指数(Ctd指数)和综合Brier评分(IBS)对模型的性能进行比较。在这五个模型中,DeepSurv的预测精度最高,而Cox-Time的预测能力最低。对于DeepSurv、Cox-CC、DeepHit、N-MTLR和Cox-Time,平均Ctd指数分别为0.773、0.767、0.765、0.732和0.659,平均IBS分别为0.181、0.192、0.195、0.212和0.225。DeepSurv、Cox CC和DeepHit的表现相当。深度学习模型摆脱了标准生存模型固有的严格假设。因此,在可扩展的现实世界生存问题中,这些模型被认为是标准方法的灵活替代方案。
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引用次数: 0
SYSTEMATIC LITERATURE REVIEW ON 3D PRINTING PERSONALISED FOOD FOR THE ELDERLY 3D打印个性化老年食品的系统文献综述
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.10
M. Haris, Nur Fatin Adlin Kamarudin, Khairul Auni Adli Mohamed Aini, Harith Juwaidi Abdul Rais, Shaiqah Mohd Rus, S. Harith
Three-dimensional (3D) printing is currently a new technology being developed in the food industry due to its ability to design, customize, and fabricate a product with good precision and accuracy. Therefore, with regard to the mastication problems frequently faced by elderly people, this technology is utilized to design foods that can be consumed by them. Since there was limited published literature on the subject, the present study aimed to systematically review 3D printing personalized food for the elderly. The study used PRISMA as a guideline for report writing while integrating multiple research designs. This paper employed three databases to select the articles: Science Direct, Scopus, and Google Scholar. The study included five analyzed themes: 1) hardness; 2) moisture; 3) viscosity; 4) elasticity; and 5) printability. The study significantly contributed to several practical purposes and the body of knowledge. The findings provided the factors affecting the 3D printing of food, its mechanisms, and its significance.
三维(3D)打印是目前食品行业正在开发的一项新技术,因为它能够设计、定制和制造具有良好精度和准确性的产品。因此,针对老年人经常面临的咀嚼问题,利用这项技术来设计他们可以食用的食物。由于有关该主题的已发表文献有限,本研究旨在系统回顾3D打印老年个性化食品。该研究将PRISMA作为报告写作的指南,同时整合了多种研究设计。本文使用三个数据库来选择文章:Science Direct、Scopus和Google Scholar。该研究包括五个分析主题:1)硬度;2) 水分;3) 粘度;4) 弹性;以及5)可打印性。这项研究对若干实际目的和知识体系作出了重大贡献。这些发现提供了影响食品3D打印的因素、机制及其意义。
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引用次数: 0
A WAITING TIME-BASED BULLY ALGORITHM FOR LEADER NODE SELECTION IN DISTRIBUTED SYSTEMS 分布式系统中基于等待时间的领导节点选择欺凌算法
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.5
Md. Navid Bin Anwar, A. Nahar, Nashid Kamal Md., Mehedi Hasan Shuvo
In distributed systems, a single node (referred to as a leader) coordinates all other nodes to ensure synchronization. If this node fails, another node in the system must adopt the role of leader. The classic bully algorithm suffers from some significant drawbacks, such as excessive message passing, a redundant number of election calls, and uncertainties over message delivery. The enhanced bully algorithm is one of the most recent improvements of this algorithm. However, this algorithm performs poorly in average- and worst-case scenarios. In this paper, a novel waiting time-based algorithm is proposed to improve the enhanced bully algorithm for electing a new leader during such critical scenarios. In this algorithm, if a single or multiple number of nodes discover that the leader has failed, it does not broadcast instantly. Rather, it waits for a certain period, and this waiting time is assigned to the nodes according to their load. After the timeout, the node sends its message and starts the election process. Moreover, it restricts nodes from unnecessary message passing and stops any redundant election calls. Accordingly, this algorithm detects the failure of the leader node more precisely and elects a new leader more quickly.
在分布式系统中,单个节点(称为领导者)协调所有其他节点以确保同步。如果这个节点失败,系统中的另一个节点必须扮演领导者的角色。经典的恶霸算法存在一些显著的缺点,例如消息传递过多、选举电话数量过多以及消息传递的不确定性。增强型霸凌算法是该算法的最新改进之一。然而,这种算法在平均情况和最坏情况下表现不佳。在这篇文章中,提出了一种新的基于等待时间的算法来改进增强的霸凌算法,以在这种关键场景中选举新的领导者。在该算法中,如果单个或多个节点发现领导者失败,它不会立即广播。相反,它会等待一段时间,并根据节点的负载将此等待时间分配给节点。超时后,节点发送消息并启动选举过程。此外,它还限制节点进行不必要的消息传递,并停止任何多余的选举调用。因此,该算法更准确地检测领导者节点的故障,并更快地选择新的领导者。
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引用次数: 0
ESTIMATION OF THERMODYNAMIC PARAMETERS OF Ni-Si BASE ALLOYS USING THE SEMI-EMPIRICAL MIEDEMA MODEL 用半经验MIEDEMA模型估算镍硅基合金的热力学参数
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.3
A. Alsaedi, F. Abbas, A. S. Alaboodi, A. Abojassim
In this paper, we present a calculation method for evaluating the possibility of enhancing the thermal stability of nickel silicide by alloying with metals, which consists in determining the formation enthalpy (∆H) of nickel silicide using the Miedema model. Changes in formation enthalpy (∆H) were observed for nickel silicides that were alloyed with Mo, Pt, Pd, W, and Zr. The MAAT (Materials Analysis Applying Thermodynamics) software was used to calculate and plot the formation enthalpy of binary and ternary systems. Based on our calculations, we found that in binary systems, the optimum values to expand the formation enthalpy were 51.28 and 49.57 kJ/mol for nickel silicide alloys. For the ternary system, the results showed that adding Zr could increase monosilicide phase stability.
本文提出了一种评价金属合金化提高硅化镍热稳定性可能性的计算方法,即利用Miedema模型确定硅化镍的生成焓(∆H)。观察了Mo、Pt、Pd、W和Zr合金硅化镍的生成焓(∆H)的变化。利用MAAT (Materials Analysis applied Thermodynamics)软件对二元和三元体系的生成焓进行了计算和绘制。通过计算发现,在二元体系中,硅化镍合金扩大生成焓的最佳值分别为: 51.28 kJ/mol和 49.57 kJ/mol。对于三元体系,结果表明加入Zr可以提高单硅化物的相稳定性。
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引用次数: 0
GASTROINTESTINAL PARASITES IN Macaca fascicularis LIVING IN TWO URBAN AREAS OF MALAYSIA 马来西亚两个城市地区猕猴的胃肠道寄生虫
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.2
Sharifah Aminah Tuan Said, J. Vejayan, Nur A’FIEFAH Binti MOHD ZULKEFFLI, Hani-Kartini Agustar
Macaca fascicularis or commonly known as long-tailed macaques, are nonhuman primates that are increasingly vulnerable in becoming natural reservoirs for many microorganisms including gastrointestinal (GI) parasites, largely due to anthropogenic activities. This study was conducted to detect and compare GI parasites in M. fascicularis found in densely urbanized settings. The fecal samples of the long-tailed macaques were collected at a public university campus (Universiti Kebangsaan Malaysia, Bangi) and a tourist site (Bukit Melawati, Kuala Selangor). A total of 80 fecal samples were collected: 50 at the university campus, and the remaining samples from the tourist site. The fecal samples were processed by flotation techniques to include the GI parasites and then were subjected to morphological analysis to identify important taxonomy keys under microscopic magnification. A total of 139 parasites were identified from both locations and classified into 5 phylums and 17 families. Among the 139 parasites, 33 parasites were grouped into 6 genus of GI parasites. Among the gastrointestinal parasites that were identified from both study sites, three parasites were zoonotic namely Strongyloids spp., Trichostrongylus spp. and Trichuris spp. Results showed that the diversity index of GI parasites was higher at the university campus compared to the tourist site with Simpson’s Index values of 0.953 and 0.880, respectively, while the Shannon’s Index values were 3.282 and 2.399, respectively. This research revealed that there are more parasite infections in the long-tailed macaques in the campus surroundings compared to those found in the tourist site. Therefore, it is highly suggested that authority intervention by translocating the long-tailed macaques elsewhere is necessary to avoid prolonged contact and possible parasite transmission to humans, and if any parasitic infections occur, appropriate medication such as anthelmintic drugs should be readily available at the university campus clinics.
束猴或俗称长尾猕猴是非人类灵长类动物,由于人类活动,它们越来越容易成为包括胃肠道寄生虫在内的许多微生物的天然宿主。这项研究是为了检测和比较密集城市环境中发现的束状分枝杆菌的胃肠道寄生虫。长尾猕猴的粪便样本是在一所公立大学校园(马来西亚班吉Kebangsaan大学)和一个旅游景点(吉隆坡Bukit Melawati)采集的。共采集了80份粪便样本:50份在大学校园,其余样本来自旅游景点。通过浮选技术对粪便样本进行处理,以包括胃肠道寄生虫,然后进行形态学分析,以在显微镜下确定重要的分类键。从这两个地点共鉴定出139种寄生虫,分为5个门和17个科。在139种寄生虫中,33种寄生虫被分为6个胃肠道寄生虫属。在从两个研究地点鉴定出的胃肠道寄生虫中,有三种寄生虫是人畜共患的,即线虫、毛滴虫和鞭虫。结果表明,与旅游景点相比,大学校园胃肠道寄生虫的多样性指数更高,Simpson指数值分别为0.953和0.880,香农指数分别为3.282和2.399。这项研究表明,与旅游景点相比,校园周围的长尾猕猴感染寄生虫的情况更多。因此,强烈建议有必要通过将长尾猕猴转移到其他地方进行权威干预,以避免长时间接触和可能的寄生虫传播给人类。如果发生任何寄生虫感染,大学校园诊所应随时提供适当的药物,如驱虫药。
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引用次数: 0
ARDUINO BASED SMART SOLAR PHOTOVOLTAIC REMOTE MONITORING SYSTEM 基于ARDUINO的智能太阳能光伏远程监控系统
Q3 Multidisciplinary Pub Date : 2022-10-31 DOI: 10.22452/mjs.vol41no3.8
V. V., S. G
The continuous monitoring system of the photo voltaic solar based energy model is currently highly crucial to monitor the overall performance and other related characteristics of energy solar energy systems from remote locations. For this, data loggers also play a vital role. These technologies are highly important to identify any malfunctions inherent in PV based solar energy systems. The proposed IoT based system is useful to obtain real time data from PV based solar energy systems from remote areas. An Arduino ATMEGA16 microcontroller was used to acquire real time data from the system, which is incorporated with the blynk app to transmit real time data to the destination through a webpage. The proposed system consists of a PV based solar system, Arduino controller board Wi-Fi module and the blynk app, in order obtain and transmit data from any remote location. We have developed a cost effective IoT based Smart monitoring system for PV based solar energy applications to monitor the various characteristics and performance of the system, as well as to carry out preventive maintenance and fault detection.
基于光伏太阳能的能源模型的连续监测系统目前对于从远程位置监测能源太阳能系统的整体性能和其他相关特性非常重要。为此,数据记录器也发挥着至关重要的作用。这些技术对于识别基于光伏的太阳能系统中固有的任何故障都非常重要。所提出的基于物联网的系统有助于从偏远地区的基于光伏的太阳能系统中获得实时数据。Arduino ATMEGA16微控制器用于从系统中获取实时数据,该系统与blynk应用程序结合在一起,通过网页将实时数据传输到目的地。所提出的系统由基于光伏的太阳能系统、Arduino控制器板Wi-Fi模块和blynk应用程序组成,以便从任何远程位置获取和传输数据。我们为基于光伏的太阳能应用开发了一种经济高效的基于物联网的智能监测系统,以监测系统的各种特性和性能,并进行预防性维护和故障检测。
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引用次数: 4
期刊
Malaysian journal of science
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