Materials Today Bio最新文献_第7页

Engineered prebiotic microcapsules Co-Encapsulating berberine and curcumin Elicit multi-synergistic therapy for ulcerative colitis 工程益生元微胶囊共封装小檗碱和姜黄素引发溃疡性结肠炎的多重协同治疗

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-07 DOI: 10.1016/j.mtbio.2026.102778

Huanyu Li , Chuanyu Zhang , Ziwei Yang , Yifan Li , Dan Liu , Yanan Zhang , Lingmin Zhang , Ning Wang , Mingxin Zhang , Mingzhen Zhang , Zhaoxiang Yu , Xueyong Wei , Yujie Zhang

Background

Ulcerative colitis (UC) is a common type of inflammatory bowel disease, where the vicious cycle of inflammation and oxidative stress poses a major challenge in its treatment, and existing therapies have limitations. Berberine (BBR) and curcumin (CUR) have the potential for synergistic treatment of UC, but this potential has not been verified in UC. Additionally, both BBR and CUR suffer from poor water solubility and low bioavailability. This study aims to construct prebiotic microcapsules (BBR/CUR@MC) for the co-delivery of BBR and CUR and explore their therapeutic mechanism in UC.

Methods

Network pharmacology was used to predict the targets and pathways of BBR and CUR in UC. BBR/CUR@MC was prepared using microfluidic electrospray technology, and its colon targeting and biocompatibility were evaluated through in vivo experiments. In a Dextran sulfate sodium (DSS)-induced UC mouse model, the therapeutic effect was assessed using multiple indicators, and the mechanism of action was explored by transcriptome analysis.

Results

Network pharmacology showed that BBR and CUR can exert therapeutic effects on UC through synergistic regulation of TNF and AGE-RAGE signaling pathways. The successfully constructed BBR/CUR@MC had good colon targeting and biocompatibility. In the mouse colitis model, oral administration of BBR/CUR@MC inhibited ADAM17 in the TNF signaling pathway and MAPK11/13, COL4A1, and COL1A1 in the AGE-RAGE signaling pathway, thereby downregulating pro-inflammatory cytokines such as TNF-α and IL-1α, upregulating IL-10, scavenging ROS, significantly alleviating colonic inflammation and repairing the intestinal barrier in mice, with a therapeutic effect superior to that of single-drug microcapsules and 5-ASA.

Conclusion

BBR/CUR@MC can exert synergistic anti-inflammatory and antioxidant effects in UC treatment by regulating TNF and AGE-RAGE signaling pathways, providing a new multi-mechanism therapeutic strategy for UC.

背景溃疡性结肠炎（UC）是一种常见的炎症性肠病，炎症和氧化应激的恶性循环对其治疗构成了重大挑战，现有治疗方法存在局限性。小檗碱（BBR）和姜黄素（CUR）具有协同治疗UC的潜力，但这种潜力尚未在UC中得到证实。此外，BBR和CUR都存在水溶性差和生物利用度低的问题。本研究旨在构建益生元微胶囊（BBR/CUR@MC），用于BBR和CUR的共给药，并探讨其治疗UC的机制。方法应用网络药理学方法预测UC中BBR和CUR的作用靶点和通路。采用微流控电喷雾技术制备BBR/CUR@MC，通过体内实验对其结肠靶向性和生物相容性进行评价。在葡聚糖硫酸钠（DSS）诱导的UC小鼠模型中，采用多指标评价其治疗效果，并通过转录组分析探讨其作用机制。结果网络药理学研究表明，BBR和CUR可通过协同调节TNF和AGE-RAGE信号通路对UC发挥治疗作用。成功构建的BBR/CUR@MC具有良好的结肠靶向性和生物相容性。在小鼠结肠炎模型中，口服BBR/CUR@MC可抑制TNF信号通路中的ADAM17和AGE-RAGE信号通路中的MAPK11/13、COL4A1、COL1A1，从而下调小鼠的TNF-α、IL-1α等促炎细胞因子，上调IL-10，清除ROS，显著缓解结肠炎症，修复肠道屏障，治疗效果优于单药微胶囊和5-ASA。结论bbr /CUR@MC通过调节TNF和AGE-RAGE信号通路，在UC治疗中发挥协同抗炎和抗氧化作用，为UC提供了一种新的多机制治疗策略。

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引用次数: 0

Dual-parameter sequential ultrasound irradiation with oxygen-loaded microbubbles induces vascular normalization to potentiate sonodynamic therapy in breast cancer 载氧微泡双参数序贯超声照射诱导血管正常化以增强乳腺癌的声动力治疗

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-07 DOI: 10.1016/j.mtbio.2026.102777

Zenan Zhang , Zichao Liu , Lingling Lei , Xiaowen Liang , Zhili Guo , Shun Liu , Jie Lan , Meng Du , Zhiyi Chen

The efficacy of sonodynamic ther cancer is limited by tumor hypoxia and the constrained bio-effects of single-parameter ultrasound. To address this, an optimized SDT strategy was established with microbubbles loaded with Chlorin e6 (Ce6) and oxygen (CMO) and a dual-parameter sequential ultrasound irradiation mode, which begins with a cavitation-inducing ultrasound (US_ca, 0.6 W/cm²) to normalize tumor vasculature and alleviates hypoxia, then followed by a sonochemical-activating ultrasound (US_sc, 1.4 W/cm²) to elicit potent tumor cell killing effect. It was demonstrated by cellular experiments that US_ca facilitated the release of oxygen and Ce6, allowing US_sc to exert maximal cytotoxicity effect. In vivo, US_ca pretreatment was indispensable for normalizing tumor vasculature, while US_sc alone was found to be vasculature-damaging. With the synergistic effect of sequential US_ca and US_sc ultrasound irradiation, superior anti-tumor effect was achieved, manifested as a 75 % reduction in tumor volume and significant outperformance over classical SDT mode. Overall, This work pioneers a dual-stage sequential ultrasound irradiation mode that tactically induces vascular nonmalization as a sensitizing step for subsequent SDT, culminating in a novel SDT strategy with high translational potential.

超声动力治疗肿瘤的疗效受到肿瘤缺氧和单参数超声生物效应的限制。为了解决这个问题，我们建立了一种优化的SDT策略，微泡加载氯e6 （Ce6）和氧（CMO），双参数顺序超声照射模式，首先是空化诱导超声（USca, 0.6 W/cm2），以使肿瘤血管正常化并缓解缺氧，然后是声化学激活超声（USsc, 1.4 W/cm2），以产生有效的肿瘤细胞杀伤作用。细胞实验表明，USca促进氧和Ce6的释放，使USsc发挥最大的细胞毒性作用。在体内，USca预处理对于肿瘤血管的正常化是必不可少的，而USsc单独被发现是血管损伤的。在USca和USsc连续超声照射的协同作用下，获得了优异的抗肿瘤效果，表现为肿瘤体积减少75%，明显优于经典SDT模式。总的来说，这项工作开创了一种双阶段连续超声照射模式，战术上诱导血管非正常化，作为后续SDT的致敏步骤，最终形成一种具有高转化潜力的新型SDT策略。

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引用次数: 0

Injectable anti-inflammatory, antioxidant supramolecular nanofiber hydrogel for peripheral nerve injury repair and neuropathic pain relief 可注射抗炎、抗氧化的超分子纳米纤维水凝胶用于周围神经损伤修复和神经性疼痛缓解

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-07 DOI: 10.1016/j.mtbio.2026.102780

Anqi Liu , Kui Sheng , Huihui Li , XinYang Zhao , Xiaojun Zhang , Haitao Su , Tsring Samdrup , Ye Zhang , Xianwen Hu , LiJun Weng , YaGuang Wang

Patients with peripheral nerve injury (PNI) often experience neuropathic pain (NP), which is difficult to treat effectively due to ongoing inflammation and oxidative stress that impede nerve repair. Traditional anti-inflammatory antioxidants are limited by short half-lives and significant side effects. This study introduces a supramolecular hydrogel formed by combining anti-inflammatory betamethasone phosphate (Betp) with calcium chloride to create betamethasone phosphate hydrogel (Betp@Gel). The antioxidant curcumin (Cur) was incorporated into this gel to form Cur/Betp@Gel, which can be injected directly at the injury site for sustained Cur release. Cur/Betp@Gel demonstrates superior sustained-release capabilities and therapeutic effectiveness compared to Betp@Gel or Cur alone. It enhances pain relief, supports functional recovery after nerve damage, and promotes nerve repair and regeneration. This is achieved by Betp@Gel's anti-inflammatory effects, which inhibit TNF-α, IL-1β, and IL-6, combined with Cur's continuous slow release, which scavenges reactive oxygen species (ROS). Additionally, Cur/Betp@Gel mitigates PNI-induced spinal inflammation by reducing GFAP and Iba-1 expression in the spinal cord. Overall, in-situ injection of Cur/Betp@Gel is a promising strategy for aiding nerve repair and alleviating neuropathic pain.

周围神经损伤（PNI）患者经常出现神经性疼痛（NP），由于持续的炎症和氧化应激阻碍神经修复，这种疼痛难以有效治疗。传统的抗炎抗氧化剂受半衰期短和显著副作用的限制。本研究介绍了一种将抗炎的磷酸倍他米松（Betp）与氯化钙结合形成的超分子水凝胶（Betp@Gel）。抗氧化剂姜黄素（Cur）加入到凝胶中形成Cur/Betp@Gel，可以直接注射到损伤部位，持续释放Cur。与Betp@Gel或单独使用Cur相比，Cur/Betp@Gel具有更好的缓释能力和治疗效果。它增强疼痛缓解，支持神经损伤后的功能恢复，促进神经修复和再生。这是通过Betp@Gel的抗炎作用，抑制TNF-α， IL-1β和IL-6，结合Cur的持续缓慢释放，清除活性氧（ROS）来实现的。此外，Cur/Betp@Gel通过降低脊髓中GFAP和Iba-1的表达来减轻pni诱导的脊髓炎症。总的来说，原位注射Cur/Betp@Gel是一种很有希望的帮助神经修复和减轻神经性疼痛的策略。

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引用次数: 0

Strategies for overcoming multiple barriers of oral administration of protein and peptide therapeutics 克服蛋白质和肽治疗药物口服给药多重障碍的策略

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-07 DOI: 10.1016/j.mtbio.2026.102763

Xiaofan Wang , Keke Wang , Yitan Fang , Youxi Zhang , Lixin Yi , Xiaohong Li , Qinfu Zhao , Xu Zhu , Shuang Cai , Long Wan

Oral delivery of protein and peptide therapeutics (PPs) offers a non-invasive, patient-friendly alternative to parenteral administration, yet faces multiple formidable barriers due to the complex gastrointestinal (GI) environment. This review provides an overview of the latest advances of strategies developed to overcome the four main GI barriers: the harsh pH environment, enzymatic degradation, the mucus layer, and the intestinal epithelial barrier. We critically evaluate various approaches including chemical modifications, permeation enhancers, encapsulation techniques, and novel delivery systems like microneedles and nanoparticle-based carriers, each designed to protect PPs and enhance their bioavailability. A comparative analysis of the advantages and limitations of these strategies is presented, along with a discussion on how to integrate them synergistically for the effective overcoming of multiple GI tract barriers. Furthermore, we examine the current challenges associated with oral PPs drug delivery systems and explore future directions aimed at achieving successful therapeutic outcomes.

口服蛋白质和肽疗法（PPs）提供了一种非侵入性的、对患者友好的肠外给药选择，但由于复杂的胃肠道（GI）环境，它面临着多重巨大的障碍。本文综述了克服四种主要胃肠道屏障的策略的最新进展：恶劣的pH环境、酶降解、黏液层和肠上皮屏障。我们批判性地评估了各种方法，包括化学修饰、渗透增强剂、封装技术和新型递送系统，如微针和纳米颗粒载体，每种方法都旨在保护PPs并提高其生物利用度。比较分析了这些策略的优点和局限性，并讨论了如何将它们协同整合以有效克服多种胃肠道障碍。此外，我们研究了目前与口服PPs药物递送系统相关的挑战，并探索了旨在实现成功治疗结果的未来方向。

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引用次数: 0

4D fabrication of scaffolds facilitates the construction of cholangiocyte monolayers from human and mouse liver derived organoids 4D支架的制造促进了人类和小鼠肝源性类器官胆管细胞单层的构建

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-07 DOI: 10.1016/j.mtbio.2025.102757

Junzhi Li , Shangsi Chen , Jing Chu , Yanghonghong Fei , Patrick Ho-Yu Chung , Kenneth Kak Yuen Wong , Vincent Chi Hang Lui , Paul Kwong Hang Tam

The blockage and absence of bile ducts lead to liver defects, highlighting the urgent need for effective regenerative solutions. Tissue engineering has emerged as an interdisciplinary solution for repairing and regenerating damaged bile duct tissue. However, challenges such as achieving good organoid viability and morphological remodeling within scaffolds remain. In this study, surface-modified biodegradable shape memory (SMP) scaffolds were designed and fabricated to construct cell-laden 3D bile duct tubes using both human and mouse liver derived cholangiocyte organoids as cell sources. The SMP scaffolds demonstrate superb biocompatibility and good shape memory properties, which support organoid attachment and integration, enhancing cholangiocytes proliferation and monolayer formation. Our cell-laden SMP scaffolds facilitated the in vitro generation of bile duct structures, addressing key challenges in scaffold design for duct regeneration. This innovative approach opens new avenues for engineering smart scaffolds for bile duct repair and regenerative medicine.

胆管堵塞和缺乏导致肝脏缺陷，突出了迫切需要有效的再生解决方案。组织工程已经成为修复和再生受损胆管组织的跨学科解决方案。然而，在支架内实现良好的类器官活力和形态重塑等挑战仍然存在。在这项研究中，设计和制造了表面修饰的可生物降解形状记忆（SMP）支架，以人类和小鼠肝源胆管细胞类器官为细胞来源，构建了承载细胞的3D胆管。SMP支架具有良好的生物相容性和形状记忆性能，支持类器官附着和整合，促进胆管细胞增殖和单层形成。我们的细胞负载SMP支架促进了胆管结构的体外生成，解决了胆管再生支架设计的关键挑战。这种创新的方法为胆管修复和再生医学的工程智能支架开辟了新的途径。

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引用次数: 0

Programmable lipid nanoparticles for RNA therapeutics: Design principles and clinical translation 用于RNA治疗的可编程脂质纳米颗粒：设计原则和临床翻译

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-07 DOI: 10.1016/j.mtbio.2026.102774

Mahdi Navid Talemi , Marzieh Ramezani Farani , Naiyereh Alipour Eskandani , Danial Mirzaee , Iraj Alipourfard , Yun Suk Huh

RNA therapeutics have come of age as clinically validated modalities including mRNA, siRNA, antisense oligonucleotides (ASOs), and in vivo genome editing, with lipid nanoparticles (LNPs) as the main non-viral delivery system. This review defines programmable LNPs as systems whose composition and interfacial chemistry are tuned to control organ tropism, cell specificity, intracellular trafficking, and immune interactions. We summarize design rules across four core components (ionizable lipid, phospholipid, cholesterol, PEG-lipid) and highlight levers like apparent pK_a optimization (∼6–7 for hepatic delivery), biodegradable linkers, PEG-anchor-dependent shedding, ligands (e.g., GalNAc), and selective organ-targeting (SORT) lipids that redirect biodistribution beyond the liver. We survey advances in data-guided formulation, including DNA-barcoded in vivo libraries, machine learning, and physics-based prediction, plus scalable manufacturing (microfluidics, confined impinging-jet mixing, tangential-flow filtration) and Quality-by-Design with process-analytical technologies. A comprehensive characterization toolkit (size/ζ-potential, cryo-EM/SAXS, RNA encapsulation and integrity, apparent pK_a, in vivo barcoding) maps to critical quality attributes. Applications span vaccines, protein replacement, siRNA/ASO delivery, and CRISPR platforms, with clinical examples like patisiran, COVID-19 and RSV mRNA vaccines, in-human transthyretin (TTR) editing, and individualized melanoma vaccination. We analyze translational constraints like endosomal escape, reactogenicity and anti-PEG immunity, complement activation, and lot-to-lot control, plus success factors: corona-aware design, dose-efficient potency at low lipid burden, redosing strategies, and fit-for-purpose biomarkers. Together, programmable LNPs offer a generalizable path to extrahepatic, cell-aware RNA medicine when coupled to rigorous analytics and platform manufacturing.

RNA疗法已经成熟，包括mRNA、siRNA、反义寡核苷酸（ASOs）和体内基因组编辑，其中脂质纳米颗粒（LNPs）是主要的非病毒传递系统。本文将可编程LNPs定义为其组成和界面化学被调整以控制器官趋向性、细胞特异性、细胞内运输和免疫相互作用的系统。我们总结了四个核心成分（可电离脂质、磷脂、胆固醇、peg -脂质）的设计规则，并强调了杠杆，如明显的pKa优化（肝脏递送~ 6-7）、可生物降解的连接物、peg锚定依赖性脱落、配体（例如GalNAc）和选择性器官靶向（SORT）脂质，这些脂质可以重新定向肝脏以外的生物分布。我们调查了数据导向配方的进展，包括dna条形码体内文库，机器学习，基于物理的预测，以及可扩展的制造（微流体，受限撞击射流混合，切向流过滤）和质量设计与过程分析技术。一个全面的表征工具包（尺寸/ζ-电位，冷冻电镜/SAXS， RNA封装和完整性，表观pKa，体内条形码）映射到关键的质量属性。应用范围包括疫苗、蛋白质替代、siRNA/ASO递送和CRISPR平台，临床例子包括patisiran、COVID-19和RSV mRNA疫苗、人体内甲状腺素（TTR）编辑和个体化黑色素瘤疫苗。我们分析了翻译限制因素，如内体逃逸、反应原性和抗peg免疫、补体激活和批次对批次控制，以及成功因素：冠状病毒感知设计、低脂负荷下的剂量效率、重给药策略和适合目的的生物标志物。总之，可编程LNPs结合严格的分析和平台制造，为肝外细胞感知RNA医学提供了一条通用的途径。

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引用次数: 0

Resveratrol-embedded hollow cerium oxide nanomedicine targeted treat inflammatory bowel disease through ROS clearance, intestinal mucosal immune homeostasis recovery and gut microbiota modulation 白藜芦醇嵌入的空心氧化铈纳米药物通过清除ROS、恢复肠黏膜免疫稳态和调节肠道微生物群靶向治疗炎症性肠病

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-07 DOI: 10.1016/j.mtbio.2026.102765

Tianlin Wang , Xiaoxia Lin , Wenjie Li , Xing Li , Xiaodong Lin , Ning Li , Yan Ma , Lianjun Song , Xianqing Huang , Tiange Li

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is difficult to cure. The crucial pathogenic factors of IBD are mainly caused by the overexpression of pro-inflammatory cytokines and the disturbance of gut microbiota triggered by excessive reactive oxygen species (ROS). Herein, the resveratrol-embedded hollow cerium oxide composite nanomaterials with surface modified hyaluronic acid (Res-CeO₂@HA) is developed to restore intestinal mucosal immune homeostasis and modulate gut microbiota via effective elimination of ROS-inflammation. The synthetic nanomedicine integrates the enzyme-like activity of CeO₂, the antioxidant properties of Res, and the targeting capabilities of HA. Results showed that Res-CeO₂@HA had significant advantages in ROS clearance and colon targeting. And it balanced the expression of inflammatory cytokines by inhibiting M1 macrophage polarization, promoting M2 macrophage polarization, and modulating the TLR4/NF-κB signaling pathway to alleviate IBD in mice. Furthermore, it is found that Res-CeO₂@HA significantly improved the homeostasis of the intestinal microbiota. This friendly and multifunctional nanomedicine may provide new strategies for the clinical treatment of IBD.

炎症性肠病（IBD）是一种难以治愈的胃肠道慢性炎症性疾病。IBD的关键致病因素主要是促炎细胞因子的过度表达和活性氧（ROS）过多引发的肠道菌群紊乱。本研究开发了白藜芦醇包埋的中空氧化铈复合纳米材料，表面修饰透明质酸（Res-CeO2@HA），通过有效消除ros炎症，恢复肠道黏膜免疫稳态，调节肠道微生物群。合成的纳米药物整合了CeO2的酶样活性、Res的抗氧化性能和HA的靶向能力。结果显示Res-CeO2@HA在ROS清除和结肠靶向方面具有显著优势。通过抑制M1巨噬细胞极化、促进M2巨噬细胞极化、调节TLR4/NF-κB信号通路平衡炎性细胞因子的表达，减轻小鼠IBD。此外，研究发现Res-CeO2@HA显著改善了肠道微生物群的稳态。这种友好的多功能纳米药物可能为IBD的临床治疗提供新的策略。

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引用次数: 0

Nanomaterial-enabled rheumatoid arthritis treatment: An advanced investigation into photonic - acoustic - gaseous multimodal therapy 纳米材料支持的类风湿关节炎治疗：光子-声学-气体多模态治疗的最新研究

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-06 DOI: 10.1016/j.mtbio.2026.102772

Yuxin Chen, Yasi Deng, Bin Li, Yupei Yang, Hanwen Yuan, Huihong Duan, Wei Wang, Huanghe Yu

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Current treatments mainly involve drugs and surgery, but face limitations like adverse effects, invasive complications, and poor outcomes. Emerging nanomaterial-mediated modalities, particularly photothermal therapy (PTT), photodynamic therapy (PDT), photoacoustic (PA) imaging, sonodynamic therapy (SDT), and gas therapy, have demonstrated the potential to address these limitations. PTT leverages near-infrared (NIR)-responsive nanomaterials to induce localised hyperthermia, triggering apoptosis in pathogenic synovial tissues. PDT relies on photoactivated nanophotosensitizers to precisely eliminate hyperplastic synovium through spatiotemporally controlled reactive oxygen species (ROS) production. PA imaging uses NIR light to excite nanoparticles, generating ultrasound signals that are reconstructed into images, enabling real-time monitoring and assessment of RA joints. SDT employs ultrasound-activated nanosensitizers to produce cytotoxic ROS for the targeted ablation of inflammatory cells. Complementing these approaches, gas therapy, mediated by hydrogen-releasing nanomaterials, exerts immunomodulatory effects by scavenging ROS and regulating the inflammatory microenvironment. This review examines cutting-edge nanotherapeutic strategies that integrate photonic, acoustic, and gaseous modalities for RA management. Through an analysis of innovative nanosystem designs and their therapeutic mechanisms, this review highlights the emerging paradigm of synergistic multimodality approaches, which improve efficacy while reducing systemic adverse effects. This review will provide novel perspectives for advancing next-generation multimodal precision therapies for autoimmune diseases.

类风湿性关节炎（RA）是一种慢性全身自身免疫性疾病。目前的治疗主要包括药物和手术，但存在副作用、侵入性并发症和预后差等局限性。新兴的纳米材料介导的治疗方式，特别是光热治疗（PTT）、光动力治疗（PDT）、光声成像（PA）、声动力治疗（SDT）和气体治疗，已经证明了解决这些限制的潜力。PTT利用近红外（NIR）响应纳米材料诱导局部热疗，触发致病性滑膜组织的细胞凋亡。PDT依靠光激活的纳米光敏剂通过时空控制活性氧（ROS）的产生来精确消除滑膜增生。PA成像使用近红外光激发纳米粒子，产生超声信号，并将其重建为图像，从而实现对RA关节的实时监测和评估。SDT采用超声激活的纳米增敏剂产生细胞毒性ROS，靶向消融炎症细胞。与这些方法互补的是，由氢释放纳米材料介导的气体疗法，通过清除ROS和调节炎症微环境来发挥免疫调节作用。本文综述了整合光子、声学和气体模式的尖端纳米治疗策略。通过对创新纳米系统设计及其治疗机制的分析，本综述强调了协同多模态方法的新兴范例，这些方法在提高疗效的同时减少了全身不良反应。这一综述将为推进下一代自身免疫性疾病的多模式精确治疗提供新的视角。

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引用次数: 0

Antithrombotic and antibacterial surface coating based on spiky silver nanoparticles: A counterattack against clotting and biofilm 基于针状银纳米粒子的抗血栓和抗菌表面涂层：对凝血和生物膜的反击

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-06 DOI: 10.1016/j.mtbio.2026.102762

Cuong Hung Luu , Shehzahdi S. Moonshi , Akriti Nepal , Binura Perera , Dimple Sajin , Haotian Cha , Dieu Ngoc Nguyen , Nam-Trung Nguyen , Hang Thu Ta

Blood-contacting medical devices such as vascular grafts, stents, and catheters are indispensable in life-saving interventions but remain prone to thrombosis and bacterial infection. These complications are often synergistic, with clot formation facilitating bacterial colonisation and biofilm growth, yet most surface coatings lack active countermeasures once thrombi or biofilms have developed. In this study, we hypothesised that integrating spiky silver-coated iron oxide nanoparticles (AgIONPs) with poly(ethylene glycol) (PEG) into a surface coating could provide both passive and active protection. AgIONPs offer strong photothermal properties under 808 nm laser irradiation for on-demand thrombolysis and biofilm disruption, while PEG contributes antifouling, anticoagulant, and biocompatible characteristics. The optimised AgIONPs–PEG coating exhibited safe photothermal heating (<45 °C), effectively lysed thrombi in static and dynamic models, and disrupted most biofilm biomass after a single irradiation cycle. Antithrombogenicity assays confirmed PEG's ability to reduce biofouling and improve haemocompatibility. Biocompatibility was further validated through in vitro, in ovo, and in vivo assays, with reduced immune-mediated inflammation. These findings highlight a multifunctional, responsive coating that could extend the lifespan and reliability of blood-contacting devices, offering a promising platform for next-generation photothermal materials in biomedical applications.

与血液接触的医疗设备，如血管移植物、支架和导管，在挽救生命的干预措施中是必不可少的，但仍然容易形成血栓和细菌感染。这些并发症通常是协同作用的，凝块的形成促进了细菌定植和生物膜的生长，然而，一旦血栓或生物膜形成，大多数表面涂层缺乏有效的对策。在这项研究中，我们假设将尖刺的镀银氧化铁纳米颗粒（AgIONPs）与聚乙二醇（PEG）结合到表面涂层中可以提供被动和主动保护。AgIONPs在808 nm激光照射下具有强大的光热特性，可用于按需溶栓和生物膜破坏，而PEG具有防污、抗凝和生物相容性特性。优化后的AgIONPs-PEG涂层具有安全的光热加热（<45°C），在静态和动态模型中有效地溶解血栓，并且在单次照射循环后破坏大多数生物膜生物量。抗血栓性试验证实了聚乙二醇减少生物污垢和改善血液相容性的能力。通过体外、蛋内和体内实验进一步验证了生物相容性，并减少了免疫介导的炎症。这些发现强调了一种多功能、反应灵敏的涂层，可以延长血液接触装置的寿命和可靠性，为下一代生物医学应用中的光热材料提供了一个有前途的平台。

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引用次数: 0

Ferritin-nanocaged aggregation-induced emission nanoaggregates for integrated sensitive detection and treatment of gastric cancer 铁蛋白纳米聚集体诱导发射纳米聚集体用于胃癌的综合敏感检测和治疗

IF 10.2 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio

Pub Date : 2026-01-06 DOI: 10.1016/j.mtbio.2026.102769

Junjian Deng , Zengxing Zhang , Kejun Li , Yongbin Zheng , Yongfa Zheng

Gastric cancer remains a global health challenge due to late diagnosis and limited targeted therapies. Herein, we report a novel dual-targeted nanoplatform, AIE@HFn-scfv, integrating aggregation-induced emission luminogens (AIEgens) with human heavy-chain ferritin (HFn) conjugated to Claudin18.2-specific single-chain variable fragments (scFv). This nanoconstruct leverages HFn's natural affinity for transferrin receptor 1 (CD71) and scFv-mediated targeting of Claudin18.2 to achieve precise tumor localization. Bioinformatics analysis confirmed co-overexpression of CD71 and Claudin18.2 in gastric cancer tissues, validating their utility as dual targets. Physicochemical characterization revealed stable nanoparticles (∼17 nm) with pH-responsive fluorescence and efficient AIEgens encapsulation. In vitro studies demonstrated enhanced cellular uptake in Claudin18.2/CD71-positive MGC803 cells, achieving 52-fold specificity over normal cells. Multimodal imaging in subcutaneous and orthotopic gastric tumor models showed superior tumor-to-background ratios compared to single-target controls, enabling submillimeter tumor detection. Photothermal therapy induced tumor ablation at 53.6 °C, eradicating tumors in 80 % of treated mice without systemic toxicity. Biodistribution studies revealed reduced hepatic accumulation due to dual targeting, enhancing circulation time. This work establishes AIE@HFn-scfv as a promising theranostic platform combining sensitive detection, precise therapy, and biosafety, addressing critical unmet needs in gastric cancer management.

由于胃癌诊断较晚和靶向治疗有限，它仍然是一个全球性的健康挑战。在此，我们报道了一个新的双靶向纳米平台AIE@HFn-scfv，将聚集诱导发射发光原（AIEgens）与人重链铁蛋白（HFn）结合到claudin18.2特异性单链可变片段（scFv）上。该纳米结构利用HFn对转铁蛋白受体1 （CD71）的天然亲和力和scfv介导的claud18.2靶向来实现精确的肿瘤定位。生物信息学分析证实了CD71和Claudin18.2在胃癌组织中共过表达，验证了它们作为双重靶点的效用。物理化学表征显示稳定的纳米颗粒（~ 17 nm）具有ph响应荧光和高效的AIEgens包封。体外研究表明，Claudin18.2/ cd71阳性MGC803细胞的细胞摄取增强，特异性比正常细胞高52倍。与单靶点对照相比，皮下和原位胃肿瘤模型的多模态成像显示出优越的肿瘤-背景比，从而实现亚毫米肿瘤检测。光热疗法在53.6°C下诱导肿瘤消融，在80%的治疗小鼠中根除肿瘤，无全身毒性。生物分布研究显示，由于双重靶向，减少了肝脏积聚，延长了循环时间。这项工作建立了AIE@HFn-scfv作为一个有前途的治疗平台，结合了敏感检测，精确治疗和生物安全性，解决了胃癌管理中关键的未满足的需求。

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