首页 > 最新文献

Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University最新文献

英文 中文
Correlation of Smart Phone Addiction with Poor Sleep Quality and Low Academic Score in Medical Students of Nishtar Medical University, South Punjab 南旁遮普省尼什塔尔医科大学医学生沉迷智能手机与睡眠质量差和学习成绩低的相关性
Pub Date : 2023-09-07 DOI: 10.48036/apims.v19i3.729
A. Pak, Inst Med Sci, G. Nasir, Ghulam Dastgeer, H. Muhammad, Umar Khan, Afshan Batool, Ahmad Naseer Khan, Aneesa Altaf, GM Nasir, Batool A Khan Khan HMU
Background: Smart phone addiction can disturb sleep quality in medical students by upsetting internal biological clock (SCN) and melatonin level which in turn adversely affects academic performance of medical students. Objectives: To correlate smart phone addiction (SPA), poor sleep quality and low academic score in medical students and its association with gender. Methodology: A Cross- sectional descriptive study was conducted on medical students of 4th and final year MBBS (who were mobile phone addict for more than one year). The percentage of last professional exam was taken as academic score. A proposed SPA diagnostic criterion was used to diagnose smart phone addict students. For SPA severity and sleep quality assessment Problematic Mobile Phone Use Questionnaire (PMPU-Q) and Pittsburgh Sleep Quality Index (PSQI) were used. Results: A total of 74 subjects having mean (SD) age of 22.24 (1.929) years presented with negative correlation between academic score and PSQI (p< 0.05) were included in the study. There was no significant association between academic score and smart phone addiction. The male students had worse score in dependency and dangerous use on PMUQ scale. The female students were worse in dangerous and problematic use of smart phone on PMUQ scale. Conclusion: The SP dependency and poor subjective sleep quality of male students were negatively associated with their academic score. The female students with low academic score were worse at PSQI score, their academic score was not significantly correlated with their smart phone addiction. Keywords: Smartphone addiction, Sleep Quality, Academic Score
背景:沉迷智能手机会扰乱体内生物钟(SCN)和褪黑激素水平,从而干扰医学生的睡眠质量,进而对医学生的学习成绩产生不利影响。 研究目的研究医学生智能手机成瘾(SPA)、睡眠质量差和学习成绩低的相关性及其与性别的关系。 研究方法对医学学士学位四年级和最后一年的医学生(使用手机超过一年)进行横断面描述性研究。最后一次专业考试的百分比作为学业成绩。研究采用了一个建议的 SPA 诊断标准来诊断智能手机成瘾的学生。SPA严重程度和睡眠质量评估采用了问题手机使用问卷(PMPU-Q)和匹兹堡睡眠质量指数(PSQI)。 结果研究共纳入 74 名受试者,平均(标清)年龄为 22.24 (1.929)岁,学业成绩与 PSQI 呈负相关(P< 0.05)。学业成绩与智能手机成瘾之间没有明显关联。在 PMUQ 量表中,男生在依赖性和危险使用方面得分较低。在 PMUQ 量表中,女生在智能手机的危险使用和问题使用方面得分较低。 结论男生的 SP 依赖性和主观睡眠质量差与学业成绩呈负相关。学业成绩较低的女生在 PSQI 评分方面较差,但其学业成绩与智能手机成瘾并无显著相关。 关键词智能手机成瘾 睡眠质量 学习成绩
{"title":"Correlation of Smart Phone Addiction with Poor Sleep Quality and Low Academic Score in Medical Students of Nishtar Medical University, South Punjab","authors":"A. Pak, Inst Med Sci, G. Nasir, Ghulam Dastgeer, H. Muhammad, Umar Khan, Afshan Batool, Ahmad Naseer Khan, Aneesa Altaf, GM Nasir, Batool A Khan Khan HMU","doi":"10.48036/apims.v19i3.729","DOIUrl":"https://doi.org/10.48036/apims.v19i3.729","url":null,"abstract":"Background: Smart phone addiction can disturb sleep quality in medical students by upsetting internal biological clock (SCN) and melatonin level which in turn adversely affects academic performance of medical students. Objectives: To correlate smart phone addiction (SPA), poor sleep quality and low academic score in medical students and its association with gender. Methodology: A Cross- sectional descriptive study was conducted on medical students of 4th and final year MBBS (who were mobile phone addict for more than one year). The percentage of last professional exam was taken as academic score. A proposed SPA diagnostic criterion was used to diagnose smart phone addict students. For SPA severity and sleep quality assessment Problematic Mobile Phone Use Questionnaire (PMPU-Q) and Pittsburgh Sleep Quality Index (PSQI) were used. Results: A total of 74 subjects having mean (SD) age of 22.24 (1.929) years presented with negative correlation between academic score and PSQI (p< 0.05) were included in the study. There was no significant association between academic score and smart phone addiction. The male students had worse score in dependency and dangerous use on PMUQ scale. The female students were worse in dangerous and problematic use of smart phone on PMUQ scale. Conclusion: The SP dependency and poor subjective sleep quality of male students were negatively associated with their academic score. The female students with low academic score were worse at PSQI score, their academic score was not significantly correlated with their smart phone addiction. Keywords: Smartphone addiction, Sleep Quality, Academic Score","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"154 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139341905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Catheter Related Blood Stream Infections in Hemodialysis Patients Treated With Trisodium Citrate as Catheter Locking Solution vs Heparin as Conventional Locking Method 使用柠檬酸三钠作为导管锁定液与使用肝素作为传统锁定法治疗血液透析患者导管相关血流感染的比较
Pub Date : 2023-09-07 DOI: 10.48036/apims.v19i3.877
A. Pak, Inst Med Sci, J. Karmani, Syed Saima Mir, Mohsin Naveed, Syed Asim, Ali Shah, Muhammad Khalid Javaid, Fareena Asim, Armughan Ahmad
Objective: To compare the frequency of temporary catheter related blood stream infections using sodium citrate as catheter locking solution with heparin as standard in hemodialysis patients. Methodology: A randomized controlled trial was conducted at a nephrology department's hemodialysis unit in Pakistan Institute of Medical Sciences (PIMS) between August 2022 and February 2023. Total 110 consecutive end-stage renal disease patients, aged above 18 years, undergoing hemodialysis with temporary central venous catheters, were divided into two groups. Group-I received trisodium citrate 46.7% as a lock solution, while Group-II received heparin 2000 U/ml (control). Results: The average age of patients in both groups was 51.98±13.57 years. The average duration of dialysis in both groups was 4.01±3.1 months and mean catheter time in Group-I was 13.65±8.29 days and in group-II was 13.40±8.33 days with statistically insignificant (p ? 0.05). The rate of CRBSI per 1000 catheter days was 3.12 days for group I and 5.14 days for group II (p = 0.001). The cumulative mean infection-free catheter survival in the trisodium citrate group was lower than the heparin group (log rank = 2.31, p = 0.128). Cox regression survival analysis between two groups; the difference in group I & II was insignificant (HR = 1.6, CI = 0.49–1.17, p = 0.201). Conclusion: There is insignificant difference between trisodium citrate 46.7% and heparin as a catheter lock solution in the survival rate of tunneled hemodialysis catheters in end-stage renal disease.
目的比较血液透析患者使用枸橼酸钠作为导管锁定溶液与肝素作为标准溶液时发生与临时导管相关的血流感染的频率。方法:随机对照试验2022 年 8 月至 2023 年 2 月期间,在巴基斯坦医学科学研究所(PIMS)肾内科血液透析室进行了一项随机对照试验。共有 110 名年龄在 18 岁以上、正在使用临时中心静脉导管进行血液透析的终末期肾病患者被分为两组。第一组接受 46.7% 枸橼酸三钠锁定液,第二组接受肝素 2000 U/ml (对照组)。结果两组患者的平均年龄为(51.98±13.57)岁。两组患者的平均透析时间为(4.01±3.1)个月,I 组患者的平均导管使用时间为(13.65±8.29)天,II 组患者的平均导管使用时间为(13.40±8.33)天,差异无统计学意义(P ? 0.05)。每 1000 个导管日的 CRBSI 发生率,I 组为 3.12 天,II 组为 5.14 天(P = 0.001)。枸橼酸三钠组的无感染导管累积平均存活率低于肝素组(对数秩 = 2.31,p = 0.128)。两组间的 Cox 回归生存分析显示,I 组和 II 组的差异不显著(HR = 1.6,CI = 0.49-1.17,P = 0.201)。结论在终末期肾病患者的隧道式血液透析导管存活率方面,46.7% 的枸橼酸三钠和肝素作为导管锁定溶液的差异并不显著。
{"title":"Comparison of Catheter Related Blood Stream Infections in Hemodialysis Patients Treated With Trisodium Citrate as Catheter Locking Solution vs Heparin as Conventional Locking Method","authors":"A. Pak, Inst Med Sci, J. Karmani, Syed Saima Mir, Mohsin Naveed, Syed Asim, Ali Shah, Muhammad Khalid Javaid, Fareena Asim, Armughan Ahmad","doi":"10.48036/apims.v19i3.877","DOIUrl":"https://doi.org/10.48036/apims.v19i3.877","url":null,"abstract":"Objective: To compare the frequency of temporary catheter related blood stream infections using sodium citrate as catheter locking solution with heparin as standard in hemodialysis patients. Methodology: A randomized controlled trial was conducted at a nephrology department's hemodialysis unit in Pakistan Institute of Medical Sciences (PIMS) between August 2022 and February 2023. Total 110 consecutive end-stage renal disease patients, aged above 18 years, undergoing hemodialysis with temporary central venous catheters, were divided into two groups. Group-I received trisodium citrate 46.7% as a lock solution, while Group-II received heparin 2000 U/ml (control). Results: The average age of patients in both groups was 51.98±13.57 years. The average duration of dialysis in both groups was 4.01±3.1 months and mean catheter time in Group-I was 13.65±8.29 days and in group-II was 13.40±8.33 days with statistically insignificant (p ? 0.05). The rate of CRBSI per 1000 catheter days was 3.12 days for group I and 5.14 days for group II (p = 0.001). The cumulative mean infection-free catheter survival in the trisodium citrate group was lower than the heparin group (log rank = 2.31, p = 0.128). Cox regression survival analysis between two groups; the difference in group I & II was insignificant (HR = 1.6, CI = 0.49–1.17, p = 0.201). Conclusion: There is insignificant difference between trisodium citrate 46.7% and heparin as a catheter lock solution in the survival rate of tunneled hemodialysis catheters in end-stage renal disease.","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"179 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139341985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuberculosis in Superficial Lymphadenopathy Based on Fine Needle Aspiration Cytology: A Cross Sectional Study 基于细针抽吸细胞学的浅表淋巴结病中的结核病:横断面研究
Pub Date : 2023-09-07 DOI: 10.48036/apims.v19i3.902
A. Pak, Inst Med Sci, Nadeem Islam Sheikh, Mehreen Babar, Aleena Hussain, Shirin Aamir, Jahangir Anjum, Muhammad Shahid, Khan, Dr. Nadeem Islam
Objective: To investigate the prevalence of tuberculosis among individuals presenting with superficial lymphadenopathy using Fine Needle Aspiration Cytology (FNAC) as a diagnostic method. Methodology: This cross-sectional research spanned three years, conducted at HBS General Hospital in Islamabad from July 2016 to June 2019. The study enrolled individuals meeting specified inclusion and exclusion criteria, presenting with superficial lymph node enlargement. All participants provided written consent before undergoing fine needle aspiration cytology (FNAC), and the diagnosis of tuberculosis relied on histopathological findings. Results: Among 632 patients aged 15 to 60 years who underwent FNAC following clinical examination and relevant lab investigations, 85.4% (n=540) exhibited cervical lymphadenopathy. Among these, 57.7% (n=312) were diagnosed with tuberculous lymphadenitis, comprising 58.3% females (n=182) and 41.6% males (n=130). Axillary lymphadenopathy was observed in 5.53% (n=35) of patients, among whom 3.64% females (n=23) and 2.1% males (n=13) were diagnosed with tuberculous lymphadenopathy. Generalized lymphadenopathy was seen in 5.1% (n=32) of cases, with 0.94% males (n=6) and 0.79% (n=5) demonstrating histological evidence of TB on FNAC. Inguinal lymphadenopathy was observed in 3.95% (n=25) of patients, including 0.94% males (n=5) and 0.47% females (n=3). Conclusion: Lymphadenopathy, a prevalent clinical condition, encompasses various underlying causes, ranging from manageable tuberculosis to malignant conditions. FNAC serves as a safe and rapid diagnostic technique, reducing the need for excisional biopsies. In this study, cervical lymph nodes were most frequently affected by tuberculous lymphadenopathy, particularly among females.
目的以细针抽吸细胞学(FNAC)作为诊断方法,调查浅表淋巴结病患者中结核病的患病率。研究方法:这项横断面研究为期三年,于 2016 年 7 月至 2019 年 6 月在伊斯兰堡 HBS 综合医院进行。研究招募了符合特定纳入和排除标准、出现浅表淋巴结肿大的患者。所有参与者在接受细针穿刺细胞学检查(FNAC)前均提交了书面同意书,结核病的诊断以组织病理学检查结果为准。研究结果在接受临床检查和相关实验室检查后进行细针穿刺细胞学检查的 632 名 15 至 60 岁患者中,85.4%(n=540)有宫颈淋巴结病变。其中,57.7%(312 人)被诊断为结核性淋巴结炎,其中女性占 58.3%(182 人),男性占 41.6%(130 人)。5.53%的患者(35人)出现腋窝淋巴结病变,其中3.64%的女性(23人)和2.1%的男性(13人)被确诊为结核性淋巴结病变。5.1%的病例(32 人)出现全身淋巴结病,其中 0.94% 的男性(6 人)和 0.79% 的男性(5 人)在 FNAC 上显示出结核病的组织学证据。3.95%(25 人)的患者出现腹股沟淋巴结病,其中男性占 0.94%(5 人),女性占 0.47%(3 人)。结论淋巴结病是一种常见的临床病症,其潜在病因多种多样,从可控制的结核病到恶性病症,不一而足。FNAC 是一种安全、快速的诊断技术,可减少切除活检的需要。在本研究中,颈淋巴结最常受到结核性淋巴结病的影响,尤其是女性。
{"title":"Tuberculosis in Superficial Lymphadenopathy Based on Fine Needle Aspiration Cytology: A Cross Sectional Study","authors":"A. Pak, Inst Med Sci, Nadeem Islam Sheikh, Mehreen Babar, Aleena Hussain, Shirin Aamir, Jahangir Anjum, Muhammad Shahid, Khan, Dr. Nadeem Islam","doi":"10.48036/apims.v19i3.902","DOIUrl":"https://doi.org/10.48036/apims.v19i3.902","url":null,"abstract":"Objective: To investigate the prevalence of tuberculosis among individuals presenting with superficial lymphadenopathy using Fine Needle Aspiration Cytology (FNAC) as a diagnostic method. Methodology: This cross-sectional research spanned three years, conducted at HBS General Hospital in Islamabad from July 2016 to June 2019. The study enrolled individuals meeting specified inclusion and exclusion criteria, presenting with superficial lymph node enlargement. All participants provided written consent before undergoing fine needle aspiration cytology (FNAC), and the diagnosis of tuberculosis relied on histopathological findings. Results: Among 632 patients aged 15 to 60 years who underwent FNAC following clinical examination and relevant lab investigations, 85.4% (n=540) exhibited cervical lymphadenopathy. Among these, 57.7% (n=312) were diagnosed with tuberculous lymphadenitis, comprising 58.3% females (n=182) and 41.6% males (n=130). Axillary lymphadenopathy was observed in 5.53% (n=35) of patients, among whom 3.64% females (n=23) and 2.1% males (n=13) were diagnosed with tuberculous lymphadenopathy. Generalized lymphadenopathy was seen in 5.1% (n=32) of cases, with 0.94% males (n=6) and 0.79% (n=5) demonstrating histological evidence of TB on FNAC. Inguinal lymphadenopathy was observed in 3.95% (n=25) of patients, including 0.94% males (n=5) and 0.47% females (n=3). Conclusion: Lymphadenopathy, a prevalent clinical condition, encompasses various underlying causes, ranging from manageable tuberculosis to malignant conditions. FNAC serves as a safe and rapid diagnostic technique, reducing the need for excisional biopsies. In this study, cervical lymph nodes were most frequently affected by tuberculous lymphadenopathy, particularly among females.","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139341980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Cranial Ultrasound and Computed Tomographic Scan Finding in Infants with Post Meningitis Complications 婴儿脑膜炎后并发症的颅脑超声与计算机断层扫描的比较
Pub Date : 2023-05-31 DOI: 10.48036/apims.v19i2.685
Umar Ajaz, Aliya Ahmed, Asim Nawaz Niazi, Fasih Hashmi, Samina Akhtar, Basit Mukhtar
Objective: To compare the findings of cranial ultrasound and computed tomographic (CT) scans in infants with post-meningitis complications.Methodology: A prospective analysis of 124 consecutive term infants was conducted in the department of radiology at the Pakistan Institute of Medical Sciences, Islamabad from August 2021 to April 2022. Transfontanelle ultrasonography was performed with a two-dimensional Sonoace 1500 ultrasound scanner (Medison Inc, South Korea 1995) equipped with a 6.5 megahertz (MHz) curvilinear small head probe. Sagittal and coronal sections were scanned using standard techniques. We included all 124 confirm cases of meningitis came to our hospital in the period through consecutive non probability sampling, which fulfilled the required sample size to test the objective in our population. Results: The average age of the infants was 4 months, with 71 (57.3%) males and 53 (42.7%) were females. Ultrasonography results were confirmed by CT scans in all patients. The diagnostic accuracy of ultrasonography was found to be 32.14%. Seizures disorders were the most common complication observed in the study population.Conclusion: Using transfontanelle ultrasound, it is possible to diagnose lesions inside the infant's brain. Transfontanelle ultrasound scans are most often requested for hydrocephalus detection and for abnormal findings. Infants with post-meningitic complications commonly suffer seizures. In post meningitic complications, ultrasound can still be used as an early non-invasive diagnostic modality despite its low diagnostic accuracy. Improved collaboration between radiologists and pediatricians can lead to better outcomes and reduced mortality and morbidity in neonates and infants.
目的:比较小儿脑膜炎后并发症的颅脑超声和CT表现。方法:对2021年8月至2022年4月在伊斯兰堡巴基斯坦医学科学研究所放射科对124名连续足月婴儿进行前瞻性分析。使用二维Sonoace 1500超声扫描仪(Medison Inc ., South Korea 1995),配备6.5兆赫(MHz)曲线小头部探头,进行经囟门超声检查。矢状面和冠状面采用标准技术扫描。通过连续的非概率抽样,我们纳入了这段时间来我院确诊的124例脑膜炎病例,满足了在我们人群中检验目标所需的样本量。结果:患儿平均年龄4月龄,男71例(57.3%),女53例(42.7%)。所有患者的超声检查结果均与CT检查结果一致。超声诊断准确率为32.14%。癫痫是研究人群中最常见的并发症。结论:应用经囟门超声诊断婴幼儿脑内病变是可行的。经囟门超声扫描最常用于脑积水检测和异常发现。患有脑膜炎后并发症的婴儿通常会出现癫痫发作。在脑膜炎后的并发症中,超声仍然可以作为一种早期的非侵入性诊断方式,尽管其诊断准确性较低。改善放射科医生和儿科医生之间的合作可以带来更好的结果,并降低新生儿和婴儿的死亡率和发病率。
{"title":"Comparison of Cranial Ultrasound and Computed Tomographic Scan Finding in Infants with Post Meningitis Complications","authors":"Umar Ajaz, Aliya Ahmed, Asim Nawaz Niazi, Fasih Hashmi, Samina Akhtar, Basit Mukhtar","doi":"10.48036/apims.v19i2.685","DOIUrl":"https://doi.org/10.48036/apims.v19i2.685","url":null,"abstract":"Objective: To compare the findings of cranial ultrasound and computed tomographic (CT) scans in infants with post-meningitis complications.\u0000Methodology: A prospective analysis of 124 consecutive term infants was conducted in the department of radiology at the Pakistan Institute of Medical Sciences, Islamabad from August 2021 to April 2022. Transfontanelle ultrasonography was performed with a two-dimensional Sonoace 1500 ultrasound scanner (Medison Inc, South Korea 1995) equipped with a 6.5 megahertz (MHz) curvilinear small head probe. Sagittal and coronal sections were scanned using standard techniques. We included all 124 confirm cases of meningitis came to our hospital in the period through consecutive non probability sampling, which fulfilled the required sample size to test the objective in our population. \u0000Results: The average age of the infants was 4 months, with 71 (57.3%) males and 53 (42.7%) were females. Ultrasonography results were confirmed by CT scans in all patients. The diagnostic accuracy of ultrasonography was found to be 32.14%. Seizures disorders were the most common complication observed in the study population.\u0000Conclusion: Using transfontanelle ultrasound, it is possible to diagnose lesions inside the infant's brain. Transfontanelle ultrasound scans are most often requested for hydrocephalus detection and for abnormal findings. Infants with post-meningitic complications commonly suffer seizures. In post meningitic complications, ultrasound can still be used as an early non-invasive diagnostic modality despite its low diagnostic accuracy. Improved collaboration between radiologists and pediatricians can lead to better outcomes and reduced mortality and morbidity in neonates and infants.","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128455534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparison of MRI versus Arthroscopy in Assessment of Anterior Cruciate Ligament Injuries of The Knee Keeping Arthroscopy as Gold Standard 以关节镜为金标准评估膝关节前交叉韧带损伤的MRI与关节镜的比较
Pub Date : 2023-05-31 DOI: 10.48036/apims.v19i2.598
Auon Shabbir Khan Niazi, Muhammad Uzair Khan Niazi, Irta Zainab, H. Mumtaz, Midhat Zahra, A. Anwer
Objective: To evaluate the correlation between Magnetic Resonance Imaging (MRI) findings and Arthroscopy in diagnosing anterior cruciate ligament (ACL) injuries, using Arthroscopy as the gold standard.Methodology: This prospective cross-sectional study was conducted at the Department of Orthopedic Surgery, Combined Military Hospital, Rawalpindi, from February to August 2019. Clinical evidence of ACL injury was present in 127 individuals. They had an MRI as well as an arthroscopy. The diagnostic efficacy of MRI for ACL tears was evaluated, and its sensitivity, specificity, PPV, NPV, and accuracy were all calculated.Comparisons between arthroscopic and magnetic resonance imaging (MRI) findings yielded three classifications: True Positive (MRI verified by Arthroscopy), True Negative (both MRI and Arthroscopy negative for ACL injury), and False Positive/False Negative (differences between MRI and Arthroscopy). The arthroscopic inspection and MRI findings were entered into SPSS 23 software for tabulation and analysis. When necessary, both descriptive and inferential statistics were used.Results: The study of statistics Arthroscopy was performed on 127 patients, either for diagnostic or therapeutic purposes. A correlation was found when all the data was analyzed and tabulated. The majority of the patients were males (85.8%) in the second and third decades of life. The sensitivity, specificity, NPV, PPV, and accuracy of MRI in diagnosing ACL injuries were 89.89%, 64.28%, 64.28%, 89.89%, and 84.25%, respectively.Conclusion: MRI is an accurate and non-invasive modality for assessing ACL tears, showing good accuracy and high sensitivity. However, Arthroscopy remains the gold standard for diagnosing ACL injuries.
目的:以关节镜检查为金标准,评价磁共振成像(MRI)与关节镜检查诊断前交叉韧带(ACL)损伤的相关性。方法:本前瞻性横断面研究于2019年2月至8月在拉瓦尔品第联合军队医院骨科进行。127例患者存在ACL损伤的临床证据。他们做了核磁共振和关节镜检查。评估MRI对前交叉韧带撕裂的诊断效果,计算其敏感性、特异性、PPV、NPV、准确性。关节镜和磁共振成像(MRI)结果的比较产生了三种分类:真阳性(通过关节镜验证的MRI),真阴性(MRI和关节镜均阴性),假阳性/假阴性(MRI和关节镜之间的差异)。关节镜检查和MRI结果输入SPSS 23软件进行制表和分析。必要时,描述性统计和推断性统计都被使用。结果:统计学研究对127例患者进行了关节镜检查,无论是诊断还是治疗目的。当对所有数据进行分析和制表时,发现了一种相关性。患者以男性居多(85.8%),年龄在二、三十岁。MRI诊断ACL损伤的敏感性、特异性、NPV、PPV和准确性分别为89.89%、64.28%、64.28%、89.89%和84.25%。结论:MRI是一种准确、无创的评估前交叉韧带撕裂的方法,具有良好的准确性和高的灵敏度。然而,关节镜检查仍然是诊断前交叉韧带损伤的金标准。
{"title":"Comparison of MRI versus Arthroscopy in Assessment of Anterior Cruciate Ligament Injuries of The Knee Keeping Arthroscopy as Gold Standard","authors":"Auon Shabbir Khan Niazi, Muhammad Uzair Khan Niazi, Irta Zainab, H. Mumtaz, Midhat Zahra, A. Anwer","doi":"10.48036/apims.v19i2.598","DOIUrl":"https://doi.org/10.48036/apims.v19i2.598","url":null,"abstract":"Objective: To evaluate the correlation between Magnetic Resonance Imaging (MRI) findings and Arthroscopy in diagnosing anterior cruciate ligament (ACL) injuries, using Arthroscopy as the gold standard.\u0000Methodology: This prospective cross-sectional study was conducted at the Department of Orthopedic Surgery, Combined Military Hospital, Rawalpindi, from February to August 2019. Clinical evidence of ACL injury was present in 127 individuals. They had an MRI as well as an arthroscopy. The diagnostic efficacy of MRI for ACL tears was evaluated, and its sensitivity, specificity, PPV, NPV, and accuracy were all calculated.\u0000Comparisons between arthroscopic and magnetic resonance imaging (MRI) findings yielded three classifications: True Positive (MRI verified by Arthroscopy), True Negative (both MRI and Arthroscopy negative for ACL injury), and False Positive/False Negative (differences between MRI and Arthroscopy). The arthroscopic inspection and MRI findings were entered into SPSS 23 software for tabulation and analysis. When necessary, both descriptive and inferential statistics were used.\u0000Results: The study of statistics Arthroscopy was performed on 127 patients, either for diagnostic or therapeutic purposes. A correlation was found when all the data was analyzed and tabulated. The majority of the patients were males (85.8%) in the second and third decades of life. The sensitivity, specificity, NPV, PPV, and accuracy of MRI in diagnosing ACL injuries were 89.89%, 64.28%, 64.28%, 89.89%, and 84.25%, respectively.\u0000Conclusion: MRI is an accurate and non-invasive modality for assessing ACL tears, showing good accuracy and high sensitivity. However, Arthroscopy remains the gold standard for diagnosing ACL injuries.","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"86 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131451687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non Surgical Causes of Acute Abdomen in Children: Surgeons Standpoint for Exclusion 儿童急腹症的非手术原因:外科医生的排除立场
Pub Date : 2023-05-31 DOI: 10.48036/apims.v19i2.734
Muhammad Tahir Ghani, Ambreen Mobaraz, Huma Azam Malik, Adil Rafiq, Fareeha Ajmal
Objectives: The aim of this study is to find out the non-surgical causes of acute abdomen, their frequencies, and to make an algorithm to make a methodology for excluding surgical abdomen.Methodology:  This descriptive case series study was carried out in departments of pediatrics and surgery in Aero hospital from January 2021 to November 2022. One hundred children with acute abdomen who were referred for surgical opinion and found to have non-surgical abdomen were included in the study. Surgical causes were ruled out after serial examinations and investigations by consultant surgeons. All non-surgical causes, their frequencies of presentation were recorded and an algorithm was made. Descriptive data was analyzed using SPPS version 25.Results: Gastroenteritis was found to be the most important cause of non-surgical acute abdomen and found in 23% (n=23) children followed by 18% (n=18) mesenteric lymphadenitis, nonspecific abdominal pain 12% (n=12), UTI 7% (n=7), worm infestation 7% (n=7), enteric ileitis 06% (n=6), Covid 05% (n=5), hepatitis 05%(n=5), constipation 04% (n=4), dengue 4% (n=4), ruptured ovarian follicle 3% (n=3), renal calculi 2% (n=2), Henoch schonlein purpura 2% (n=2) and gastritis 2% (n=2). An algorithm also made at the end of study to help treating surgeons to rule out surgical abdomen.Conclusion: Gastroenteritis is the leading cause of acute non-surgical abdomen in children along with many other causes and these must be carefully ruled out by an algorithm to avoid unnecessary surgeries.
目的:本研究的目的是找出急腹症的非手术原因及其发生频率,并制定一种算法来制定排除急腹症的方法。方法:本描述性病例系列研究于2021年1月至2022年11月在Aero医院儿科和外科进行。本研究共纳入100例急腹症患儿,这些患儿在接受手术治疗后被发现患有非手术性腹部。外科顾问医生进行一系列检查和调查后,排除了手术原因。记录所有非手术原因的出现频率,并制定算法。描述性数据使用SPPS版本25进行分析。结果:肠胃炎是非手术急腹症最主要的病因,在23例患儿中占23%,其次是肠膜淋巴结炎18例(18例)、非特异性腹痛12例(12例)、尿路感染7例(7例)、蠕虫感染7例(7例)、肠回肠炎06%(6例)、新冠肺炎05%(5例)、肝炎05%(5例)、便秘04%(4例)、登革热4%(4例)、卵巢卵泡破裂3%(3例)、肾结石2%(2例)、过敏性紫癜2%(2例)、胃炎2%(2例)。在研究结束时,还制定了一种算法,以帮助治疗外科医生排除手术腹部。结论:胃肠炎是儿童急性非手术性腹部的主要原因,并伴有许多其他原因,必须通过算法仔细排除这些原因,以避免不必要的手术。
{"title":"Non Surgical Causes of Acute Abdomen in Children: Surgeons Standpoint for Exclusion","authors":"Muhammad Tahir Ghani, Ambreen Mobaraz, Huma Azam Malik, Adil Rafiq, Fareeha Ajmal","doi":"10.48036/apims.v19i2.734","DOIUrl":"https://doi.org/10.48036/apims.v19i2.734","url":null,"abstract":"Objectives: The aim of this study is to find out the non-surgical causes of acute abdomen, their frequencies, and to make an algorithm to make a methodology for excluding surgical abdomen.\u0000Methodology:  This descriptive case series study was carried out in departments of pediatrics and surgery in Aero hospital from January 2021 to November 2022. One hundred children with acute abdomen who were referred for surgical opinion and found to have non-surgical abdomen were included in the study. Surgical causes were ruled out after serial examinations and investigations by consultant surgeons. All non-surgical causes, their frequencies of presentation were recorded and an algorithm was made. Descriptive data was analyzed using SPPS version 25.\u0000Results: Gastroenteritis was found to be the most important cause of non-surgical acute abdomen and found in 23% (n=23) children followed by 18% (n=18) mesenteric lymphadenitis, nonspecific abdominal pain 12% (n=12), UTI 7% (n=7), worm infestation 7% (n=7), enteric ileitis 06% (n=6), Covid 05% (n=5), hepatitis 05%(n=5), constipation 04% (n=4), dengue 4% (n=4), ruptured ovarian follicle 3% (n=3), renal calculi 2% (n=2), Henoch schonlein purpura 2% (n=2) and gastritis 2% (n=2). An algorithm also made at the end of study to help treating surgeons to rule out surgical abdomen.\u0000Conclusion: Gastroenteritis is the leading cause of acute non-surgical abdomen in children along with many other causes and these must be carefully ruled out by an algorithm to avoid unnecessary surgeries.","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134121405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-Amputation Anxiety Among Patients Reporting to Rehabilitation Centers in Quetta 奎达康复中心报告患者截肢后的焦虑
Pub Date : 2023-05-31 DOI: 10.48036/apims.v19i2.747
Abdul Baqi Khan, Shahrukh Khan, Muhammad Umair, Qasim Zia, F. Iqbal, Rabia Mahmood
Objective: To evaluate the level of Post-amputation anxiety among patients reporting to rehabilitation centers in QuettaMethodology: This Cross-sectional research was done in Quetta at the three rehabilitation centres from May-July 2018. Clients with amputations were included, and then data collected through a structured-adopted questionnaire for "Hospital Anxiety and Depression Scale". 54 subjects were involved, according to inclusion & exclusion criteria. Frequencies and percentages were described for categorical variables, and data was stratified by reason for amputation, gender, level of education, and marital status with respect to an outcome variable, anxiety. The collected data was then tabularized & analyzed by using Chi-square test.Results: Out of 54 participants, 47 were men while 7 were women. Data displayed that 30 (55.6%) were normal & 24 (44.4%) had anxiety. 49(91%) & 5(9%) participants were having lower & upper limb amputations, respectively. Results indicate that level of anxiety among participants had a statistically non significant relationship with a level/type of amputation.Conclusion: Anxiety and amputation have significant impacts on functional impairment, psychological reactions, and quality of life. The research highlights the association between amputation and anxiety, providing insight to healthcare providers that anxiety is a common occurrence in the context of amputation. The findings of this study can be valuable for prevention strategies.
目的:评估奎达康复中心报告患者截肢后焦虑水平。方法:本横断面研究于2018年5月至7月在奎达的三家康复中心进行。本研究以截肢病人为研究对象,采用“医院焦虑抑郁量表”问卷收集数据。根据纳入和排除标准,共纳入54名受试者。描述了分类变量的频率和百分比,并根据截肢原因、性别、教育水平和婚姻状况对结果变量焦虑进行了分层。然后将收集到的数据用卡方检验进行制表和分析。结果:54名参与者中,男性47人,女性7人。正常30例(55.6%),焦虑24例(44.4%)。49例(91%)和5例(9%)受试者分别有下肢和上肢截肢。结果表明,参与者的焦虑水平与截肢程度/类型没有统计学上的显著关系。结论:焦虑和截肢对功能障碍、心理反应和生活质量有显著影响。该研究强调了截肢和焦虑之间的联系,为医疗保健提供者提供了洞察力,即焦虑在截肢的情况下是常见的。这项研究的发现对预防策略有价值。
{"title":"Post-Amputation Anxiety Among Patients Reporting to Rehabilitation Centers in Quetta","authors":"Abdul Baqi Khan, Shahrukh Khan, Muhammad Umair, Qasim Zia, F. Iqbal, Rabia Mahmood","doi":"10.48036/apims.v19i2.747","DOIUrl":"https://doi.org/10.48036/apims.v19i2.747","url":null,"abstract":"Objective: To evaluate the level of Post-amputation anxiety among patients reporting to rehabilitation centers in Quetta\u0000Methodology: This Cross-sectional research was done in Quetta at the three rehabilitation centres from May-July 2018. Clients with amputations were included, and then data collected through a structured-adopted questionnaire for \"Hospital Anxiety and Depression Scale\". 54 subjects were involved, according to inclusion & exclusion criteria. Frequencies and percentages were described for categorical variables, and data was stratified by reason for amputation, gender, level of education, and marital status with respect to an outcome variable, anxiety. The collected data was then tabularized & analyzed by using Chi-square test.\u0000Results: Out of 54 participants, 47 were men while 7 were women. Data displayed that 30 (55.6%) were normal & 24 (44.4%) had anxiety. 49(91%) & 5(9%) participants were having lower & upper limb amputations, respectively. Results indicate that level of anxiety among participants had a statistically non significant relationship with a level/type of amputation.\u0000Conclusion: Anxiety and amputation have significant impacts on functional impairment, psychological reactions, and quality of life. The research highlights the association between amputation and anxiety, providing insight to healthcare providers that anxiety is a common occurrence in the context of amputation. The findings of this study can be valuable for prevention strategies.","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131202159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Botulinum Toxin Along with Task-Specific Training in Post-Stroke Quality of Life in Focal Hand Dystonia 肉毒杆菌毒素与特定任务训练对局灶性手肌张力障碍中风后生活质量的影响
Pub Date : 2023-05-31 DOI: 10.48036/apims.v19i2.845
A. Pak, Inst Med Sci, M. Umar, Misbah Marryam, Muhammad Salman, Hiba Rashid, M. Badshah
Objective: To investigate the impact of BOTOX, along with task-specific training, on focal hand dystonia in post-stroke patients and to determine the correlation between quality of life and motor outcomes in upper extremity dystonic patients.Methodology: A quasi-experimental involving 20 patients, study was conducted at Holy Family Hospital (HFH), Chambeli Institute of Rehabilitation in Rawalpindi, and Neurocounsel Clinic in Islamabad. A convenient sampling technique was utilized to select participants for inclusion in the study. Assessments were conducted at four time points: baseline (0 weeks), 4 weeks, 8 weeks, and 12 weeks. The assessment tools used were the Abductor Digiti Minimi Abduction (ADDA) test, Modified Ashworth Scale (MAS), and Stroke-Specific Quality of Life (SS-QoL) questionnaire. Repeated measures ANOVA was employed to analyze mean differences in data across various weeks. The associations between scales were evaluated using Spearman's rho and Pearson correlation coefficients, based on different variables.Results: The mean age was 42.7 ± 10.45 years. The study included 14 males and 6 females. Repeated measures ANOVA indicated a significant difference between MAS scores for upper extremity and quality of life in post-stroke dystonic patients, with a p-value of 0.001**. A strong positive correlation coefficient was found between MAS and SS-QoL through Spearman's correlation analysis, with a p-value of less than 0.05.Conclusion: The administration of Type a Botulinum toxin, coupled with task-specific training, not only exhibited improvements in upper limb motor outcomes but also in the quality of life of focal hand dystonic patients after a stroke.
目的:探讨肉毒杆菌毒素配合特定任务训练对脑卒中后局灶性手肌张力障碍患者的影响,并确定上肢肌张力障碍患者的生活质量与运动预后之间的相关性。方法:在圣家医院(HFH)、拉瓦尔品第Chambeli康复研究所和伊斯兰堡Neurocounsel诊所进行了一项涉及20名患者的准实验研究。采用方便的抽样技术来选择纳入研究的参与者。评估在4个时间点进行:基线(0周)、4周、8周和12周。使用的评估工具是外展极小指外展(ADDA)测试、改良Ashworth量表(MAS)和卒中特异性生活质量(SS-QoL)问卷。采用重复测量方差分析分析各周数据的平均差异。根据不同的变量,使用Spearman's rho和Pearson相关系数来评估量表之间的关联。结果:平均年龄42.7±10.45岁。该研究包括14名男性和6名女性。重复测量方差分析显示,脑卒中后肌张力障碍患者上肢MAS评分与生活质量之间存在显著差异,p值为0.001**。Spearman相关分析发现MAS与SS-QoL之间存在较强的正相关系数,p值小于0.05。结论:a型肉毒杆菌毒素的使用,加上任务特异性训练,不仅可以改善中风后局灶性手张力障碍患者的上肢运动结果,而且可以改善患者的生活质量。
{"title":"Impact of Botulinum Toxin Along with Task-Specific Training in Post-Stroke Quality of Life in Focal Hand Dystonia","authors":"A. Pak, Inst Med Sci, M. Umar, Misbah Marryam, Muhammad Salman, Hiba Rashid, M. Badshah","doi":"10.48036/apims.v19i2.845","DOIUrl":"https://doi.org/10.48036/apims.v19i2.845","url":null,"abstract":"Objective: To investigate the impact of BOTOX, along with task-specific training, on focal hand dystonia in post-stroke patients and to determine the correlation between quality of life and motor outcomes in upper extremity dystonic patients.\u0000Methodology: A quasi-experimental involving 20 patients, study was conducted at Holy Family Hospital (HFH), Chambeli Institute of Rehabilitation in Rawalpindi, and Neurocounsel Clinic in Islamabad. A convenient sampling technique was utilized to select participants for inclusion in the study. Assessments were conducted at four time points: baseline (0 weeks), 4 weeks, 8 weeks, and 12 weeks. The assessment tools used were the Abductor Digiti Minimi Abduction (ADDA) test, Modified Ashworth Scale (MAS), and Stroke-Specific Quality of Life (SS-QoL) questionnaire. Repeated measures ANOVA was employed to analyze mean differences in data across various weeks. The associations between scales were evaluated using Spearman's rho and Pearson correlation coefficients, based on different variables.\u0000Results: The mean age was 42.7 ± 10.45 years. The study included 14 males and 6 females. Repeated measures ANOVA indicated a significant difference between MAS scores for upper extremity and quality of life in post-stroke dystonic patients, with a p-value of 0.001**. A strong positive correlation coefficient was found between MAS and SS-QoL through Spearman's correlation analysis, with a p-value of less than 0.05.\u0000Conclusion: The administration of Type a Botulinum toxin, coupled with task-specific training, not only exhibited improvements in upper limb motor outcomes but also in the quality of life of focal hand dystonic patients after a stroke.","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123168160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Serum Lipid Profile; Indicator of Early Changes in Head and Neck Cancer Cells 血脂的作用;头颈部癌细胞早期变化的指标
Pub Date : 2023-05-31 DOI: 10.48036/apims.v19i2.576
A. Pak, Inst Med Sci, Ansab Hasnain Naqvi, Manza Maqsood Khan, A. Hussain, S. Hasnain, M. Naqvi, Syeda Mehak Hasnain, Jawad Faisal
Objective: The objective of this study was to investigate the role of serum lipid profile as an indicator of early changes in head and neck cancer cells and to assess the potential value of these changes in detecting neoplastic cell alterations at an early stage.Methodology: The Hospital-based case-control study was carried out on 48 patients with newly diagnosed Head & Neck malignancies, attending the Department of Otorhinolaryngology and Head and Neck Surgery Pakistan Institute of Medical Sciences Islamabad between July 2020 and December 2020. Forty-eight Age and sex-matched who did not have any renal, hepatic or cardiac dysfunction were taken as controls. Fasting blood samples were drawn and analyzed for lipid profile as recommended in the literature.Results: A significant change in plasma lipid profile with P values of Total Cholesterol (0.000), Triglyceride (0.004), and HDL (0.009) of <0.05 indicates that there is a statistically significant reduction of mean serum Total Cholesterol, Triglyceride, and HDL in subjects with head and neck cancer compared to the control group.Conclusion: The altered plasma lipid status observed in this study suggests its potential as a valuable signal for early alterations in neoplastic cells associated with head and neck malignancies. Furthermore, a comprehensive review focusing on cholesterol-carrying lipoprotein transportation and the efficacy of receptor systems may contribute to a better understanding of the underlying mechanisms controlling plasma cholesterol concentration in the context of cancer.
目的:本研究的目的是探讨血清脂质谱作为头颈部癌细胞早期变化的指标的作用,并评估这些变化在早期检测肿瘤细胞变化中的潜在价值。方法:以医院为基础的病例对照研究对2020年7月至2020年12月期间在巴基斯坦伊斯兰堡医学科学研究所耳鼻喉科和头颈外科就诊的48例新诊断的头颈部恶性肿瘤患者进行了研究。48例年龄和性别相匹配的无肾、肝、心功能不全者作为对照。按照文献中推荐的方法,抽取空腹血样并分析血脂。结果:血浆脂质谱变化显著,总胆固醇(0.000)、甘油三酯(0.004)、高密度脂蛋白(0.009)的P值<0.05,表明头颈癌患者的平均血清总胆固醇、甘油三酯和高密度脂蛋白较对照组有统计学意义的降低。结论:本研究中观察到的血浆脂质状态的改变表明,它可能是头颈部恶性肿瘤相关肿瘤细胞早期改变的一个有价值的信号。此外,对携带胆固醇的脂蛋白运输和受体系统的功效进行全面的综述可能有助于更好地理解癌症背景下控制血浆胆固醇浓度的潜在机制。
{"title":"Role of Serum Lipid Profile; Indicator of Early Changes in Head and Neck Cancer Cells","authors":"A. Pak, Inst Med Sci, Ansab Hasnain Naqvi, Manza Maqsood Khan, A. Hussain, S. Hasnain, M. Naqvi, Syeda Mehak Hasnain, Jawad Faisal","doi":"10.48036/apims.v19i2.576","DOIUrl":"https://doi.org/10.48036/apims.v19i2.576","url":null,"abstract":"Objective: The objective of this study was to investigate the role of serum lipid profile as an indicator of early changes in head and neck cancer cells and to assess the potential value of these changes in detecting neoplastic cell alterations at an early stage.\u0000Methodology: The Hospital-based case-control study was carried out on 48 patients with newly diagnosed Head & Neck malignancies, attending the Department of Otorhinolaryngology and Head and Neck Surgery Pakistan Institute of Medical Sciences Islamabad between July 2020 and December 2020. Forty-eight Age and sex-matched who did not have any renal, hepatic or cardiac dysfunction were taken as controls. Fasting blood samples were drawn and analyzed for lipid profile as recommended in the literature.\u0000Results: A significant change in plasma lipid profile with P values of Total Cholesterol (0.000), Triglyceride (0.004), and HDL (0.009) of <0.05 indicates that there is a statistically significant reduction of mean serum Total Cholesterol, Triglyceride, and HDL in subjects with head and neck cancer compared to the control group.\u0000Conclusion: The altered plasma lipid status observed in this study suggests its potential as a valuable signal for early alterations in neoplastic cells associated with head and neck malignancies. Furthermore, a comprehensive review focusing on cholesterol-carrying lipoprotein transportation and the efficacy of receptor systems may contribute to a better understanding of the underlying mechanisms controlling plasma cholesterol concentration in the context of cancer.","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124162923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Regulations in Improving Quality of Blood Transfusion Services in Islamabad; Recent Developments and Future Strategies 法规在提高伊斯兰堡输血服务质量方面的作用最近的发展和未来的战略
Pub Date : 2023-05-31 DOI: 10.48036/apims.v19i2.814
A. Pak, Inst Med Sci, Quaid Saeed, U. Waheed
Ann Pak Inst Med Sci April-June 2023 Vol. 19 No. 2 52 Role of Regulations in Improving Quality of Blood Transfusion Services in Islamabad: Recent Developments and Future Strategies Quaid Saeed, Usman Waheed 1 Islamabad Healthcare Regulatory Authority, Ministry of National Health Services, Regulations, & Coordination, Islamabad, 2 Department of Allied Health Sciences, Islamabad Medical and Dental College, Islamabad
巴基斯坦医学研究所2023年4月- 6月第19卷第2期52提高伊斯兰堡输血服务质量的法规作用:最近的发展和未来的战略Quaid Saeed, Usman Waheed 1伊斯兰堡医疗保健监管机构,国家卫生服务,法规和协调部,伊斯兰堡,2联合健康科学系,伊斯兰堡医学和牙科学院,伊斯兰堡
{"title":"Role of Regulations in Improving Quality of Blood Transfusion Services in Islamabad; Recent Developments and Future Strategies","authors":"A. Pak, Inst Med Sci, Quaid Saeed, U. Waheed","doi":"10.48036/apims.v19i2.814","DOIUrl":"https://doi.org/10.48036/apims.v19i2.814","url":null,"abstract":"Ann Pak Inst Med Sci April-June 2023 Vol. 19 No. 2 52 Role of Regulations in Improving Quality of Blood Transfusion Services in Islamabad: Recent Developments and Future Strategies Quaid Saeed, Usman Waheed 1 Islamabad Healthcare Regulatory Authority, Ministry of National Health Services, Regulations, & Coordination, Islamabad, 2 Department of Allied Health Sciences, Islamabad Medical and Dental College, Islamabad","PeriodicalId":184398,"journal":{"name":"Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128944556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1