{"title":"Differences in symptoms and utility of MEWS score in geriatric patients with COVID-19","authors":"Julia Gólska, Krzysztof Białkowski, T. Kłosiewicz","doi":"10.5603/mrj.a2022.0052","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0052","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75286826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Szukay, K. Tojek, G. Kowalczyk, N. Mysiak, J. Budzyński
{"title":"Nutritional and functional status as indices of short- and long-term prognosis in patients undergoing surgery due to colorectal cancer","authors":"B. Szukay, K. Tojek, G. Kowalczyk, N. Mysiak, J. Budzyński","doi":"10.5603/mrj.a2022.0054","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0054","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74483534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jakub Ratajczak, A. Sukiennik, M. Woźnicki, J. Kubica
{"title":"Percutaneous closure of the iatrogenic atrial septal defect following the transcatheter edge-to-edge mitral valve repair with MitraClip system led to instant improvement of hypoxemia — case report","authors":"Jakub Ratajczak, A. Sukiennik, M. Woźnicki, J. Kubica","doi":"10.5603/mrj.a2022.0053","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0053","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74641834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnieszka Mlicka, Wioletta Zielińska, Klaudia Mikołajczyk, Marta Hałas-Wiśniewska, M. Izdebska, A. Grzanka
{"title":"Synergistic effect of oxymatrine and 5-fluorouracil on the migratory potential in A549 non-small cell lung cancer cells","authors":"Agnieszka Mlicka, Wioletta Zielińska, Klaudia Mikołajczyk, Marta Hałas-Wiśniewska, M. Izdebska, A. Grzanka","doi":"10.5603/mrj.a2022.0050","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0050","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81073873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Szczepanowski, M. Wójta-Kempa, A. Pawlak, Jolanta Kolasa, Izabella Uchmanowicz, M. Czapla, Tomasz Cyrkot
{"title":"Depressive and anxiety disorders in the cardiological conditions: psychological interventions","authors":"R. Szczepanowski, M. Wójta-Kempa, A. Pawlak, Jolanta Kolasa, Izabella Uchmanowicz, M. Czapla, Tomasz Cyrkot","doi":"10.5603/mrj.a2022.0051","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0051","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79216474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Łukasz Dudziński, Piotr Konrad Leszczyński, Marcin Glinka, Marek Marzec, Michał Langner, Mariusz Feltynowski, M. Panczyk, P. Glinka
Introduction: The aim of the study was to assess the knowledge of the procedure for clearing the respiratory tract and updated qualified first aid (QFA) 1a and 2a procedures by firefighters serving in State Fire Service (SFS) rescue and firefighting units, and their knowledge of the transmission of the SARS-CoV-2 virus. Material and methods: The cross-sectional study covered 19 408 firefighters (officers serving in SFS rescue and firefighting units from all over Poland). The study was conducted using the diagnostic survey method, the Computer Assisted Web Interview (CAWI) technique consisting of a set of particulars regarding a specific officer and the appropriate medical part of the survey. Results: In the group of 19,408 respondents, 99.31% were men (n = 19,275), while women accounted for 0.69% (n = 133; p < 0.001). The age of the respondents was in the range of 18–66 years, and the average age was 35.88 ± 7.14 years. The length of service was 11.95 ± 6.44 years. The knowledge of procedures 1a and 2a declared by the respondents [OR = 1.51 (95% CI: 1.22–1.86), x 2 = 14.76], the ability to operate a suction unit [OR = 1.73 (95% CI: 1.44–2.08, x 2 = 34.58)], the frequency of airway clearance training (p < < 0.001, x 2 = 61.74). Only 15% of respondents used a suction unit on an injured person during operations. Conclusions: The knowledge of firefighters in the subject matter covered by the analysis is diverse, some firefighters have additional experience and practice from working in health care units. Professional development in the field of QFA supplemented with procedures 1a and 2a may translate into a lower risk of infection associated with airway clearing in the era of the pandemic. There is a visible need for constant training of SFS officers in terms of medical activities to maintain the knowledge of firefighters at a high initial level.
{"title":"Firefighters’ knowledge of the knowledge of procedures for clearing the respiratory tract in an injured person with suspected infection with biological material (SARS-CoV-2) — a nationwide cross- -sectional study","authors":"Łukasz Dudziński, Piotr Konrad Leszczyński, Marcin Glinka, Marek Marzec, Michał Langner, Mariusz Feltynowski, M. Panczyk, P. Glinka","doi":"10.5603/mrj.a2022.0049","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0049","url":null,"abstract":"Introduction: The aim of the study was to assess the knowledge of the procedure for clearing the respiratory tract and updated qualified first aid (QFA) 1a and 2a procedures by firefighters serving in State Fire Service (SFS) rescue and firefighting units, and their knowledge of the transmission of the SARS-CoV-2 virus. Material and methods: The cross-sectional study covered 19 408 firefighters (officers serving in SFS rescue and firefighting units from all over Poland). The study was conducted using the diagnostic survey method, the Computer Assisted Web Interview (CAWI) technique consisting of a set of particulars regarding a specific officer and the appropriate medical part of the survey. Results: In the group of 19,408 respondents, 99.31% were men (n = 19,275), while women accounted for 0.69% (n = 133; p < 0.001). The age of the respondents was in the range of 18–66 years, and the average age was 35.88 ± 7.14 years. The length of service was 11.95 ± 6.44 years. The knowledge of procedures 1a and 2a declared by the respondents [OR = 1.51 (95% CI: 1.22–1.86), x 2 = 14.76], the ability to operate a suction unit [OR = 1.73 (95% CI: 1.44–2.08, x 2 = 34.58)], the frequency of airway clearance training (p < < 0.001, x 2 = 61.74). Only 15% of respondents used a suction unit on an injured person during operations. Conclusions: The knowledge of firefighters in the subject matter covered by the analysis is diverse, some firefighters have additional experience and practice from working in health care units. Professional development in the field of QFA supplemented with procedures 1a and 2a may translate into a lower risk of infection associated with airway clearing in the era of the pandemic. There is a visible need for constant training of SFS officers in terms of medical activities to maintain the knowledge of firefighters at a high initial level.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78563501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Granulocyte transfusion vs. neutropenia — is there a chance to win this battle?","authors":"Artur Szumowski, P. Radziwon","doi":"10.5603/mrj.a2022.0048","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0048","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91003569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Gałązka, Dorota Starownik, B. Kasztelan-Szczerbińska, H. Cichoż-Lach
{"title":"Imported parasitosis as a diagnostic challenge in Primary Healthcare Clinic in the non-endemic region — a case study of schistosomiasis in English Division student","authors":"J. Gałązka, Dorota Starownik, B. Kasztelan-Szczerbińska, H. Cichoż-Lach","doi":"10.5603/mrj.a2022.0047","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0047","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88512077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kubica, P. Michalski, Łukasz Pietrzykowski, Alicja Rzepka-Cholasińska, A. Kosobucka-Ozdoba, Małgorzata Jasiewicz, E. Laskowska, Jacek Kryś, M. Ostrowska
{"title":"Post-COVID-19 rehabilitation (PCR-SIRIO 8) study. A rationale and protocol of the study","authors":"A. Kubica, P. Michalski, Łukasz Pietrzykowski, Alicja Rzepka-Cholasińska, A. Kosobucka-Ozdoba, Małgorzata Jasiewicz, E. Laskowska, Jacek Kryś, M. Ostrowska","doi":"10.5603/mrj.a2022.0046","DOIUrl":"https://doi.org/10.5603/mrj.a2022.0046","url":null,"abstract":"","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77804703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Icaritin is a prenylflavonoid derivative from a traditional Chinese herb, Epimedium Genus. Icaritin exerts its anti-tumour effects in various cancers mainly by inhibiting cell proliferation, inducing cell differentiation and apoptosis, and suppressing cell migration and invasion. The study aimed to evaluate the effect of icaritin on apoptosis, cell cycle, and expression of selected cell cycle proteins: RhoA, ROCK1, and ROCK2 in the A549 cell line. Methods: Apoptosis and the cell cycle distribution were evaluated by flow cytometry. Protein expression was measured by conducting a western blot assay and immunofluorescence staining. Results and conclusions: The study revealed that icaritin induces apoptosis and cell cycle arrest in the G2/M phase in A549 cells. The authors showed that icaritin activates the p53 protein and downregulates Rho/ROCK pathway. Additionally, the decrease in expression of thrombospondin-1 was observed which can be part of the cytoprotective response of A549 cells on ICT treatment. The present study investigates the antitumour prop-erties of icaritin and conducts molecular analysis to show that ICT exerts its effect via the RhoA/ROCK pathway.
{"title":"Icaritin induces apoptosis and downregulates RhoA/ROCK pathway in the A549 adenocarcinoma cell line","authors":"A. Żuryń, Adrian Krajewski","doi":"10.5603/mrj.2022.0045","DOIUrl":"https://doi.org/10.5603/mrj.2022.0045","url":null,"abstract":"Introduction: Icaritin is a prenylflavonoid derivative from a traditional Chinese herb, Epimedium Genus. Icaritin exerts its anti-tumour effects in various cancers mainly by inhibiting cell proliferation, inducing cell differentiation and apoptosis, and suppressing cell migration and invasion. The study aimed to evaluate the effect of icaritin on apoptosis, cell cycle, and expression of selected cell cycle proteins: RhoA, ROCK1, and ROCK2 in the A549 cell line. Methods: Apoptosis and the cell cycle distribution were evaluated by flow cytometry. Protein expression was measured by conducting a western blot assay and immunofluorescence staining. Results and conclusions: The study revealed that icaritin induces apoptosis and cell cycle arrest in the G2/M phase in A549 cells. The authors showed that icaritin activates the p53 protein and downregulates Rho/ROCK pathway. Additionally, the decrease in expression of thrombospondin-1 was observed which can be part of the cytoprotective response of A549 cells on ICT treatment. The present study investigates the antitumour prop-erties of icaritin and conducts molecular analysis to show that ICT exerts its effect via the RhoA/ROCK pathway.","PeriodicalId":18485,"journal":{"name":"Medical Research Journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82643909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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