G. Atakul, S. Al, Özge Atay, Özge Kangallı Boyacıoğlu, S. Asilsoy, N. Uzuner
Objective: Cow’s milk allergy (CMA) is one of the most common food allergies in infants. The natural history of CMA indicates that resolution is common. Some studies suggest that food allergies are now being resolved at an older age. The aim of this study was to investigate the tolerance and persistence characteristics, as well as the timing of tolerance, in our own CMA patients. Material and Methods: Patients who were diagnosed with CMA and followed up in our pediatric immunology and allergy outpatient clinic between 2016-2021 years were evaluated retrospectively. Patients’ demographic characteristics, laboratory results, and tolerance time were recorded. Results: The 632 patients’ files were reviewed. 192 (30%) of the patients were followed for more than two years. The tolerance to baked products was observed with a median of 14 months, while the tolerance to fermented products was observed with a median of 17 months. Full tolerance was observed with a median of 25 months. The number of patients older than 2 years of age who could not consume any milk protein-containing product was 72 (11.4%) and 56 (77.7%) of them were IgE mediated CMA. The rate of girls with tolerance (43.5%) was found to be significantly higher than nontolerant girls (25%) (p=0.001). The mean skin test diameter of the tolerant group was significantly higher than the mean of the non-tolerant group (p=0.022). The percentage of eosinophils (p=0.003) and total IgE level (p=0.004) in the tolerant group were significantly lower compared to the intolerant group. There was no significant difference between the presence of tolerance in terms of allergy number, eosinophil count and specific IgE count (p>0.05). Conclusion: Identifying the factors influencing tolerance can lead to changes in the management of the disease. We observed that 88.6% of patients older than 2 years were tolerant to milk proteins, and all patients with non-IgE mediated CMA achieved tolerance by 2 years of age. The ratio of total IgE to specific IgE, age, total IgE and specific IgE levels, presence of non-IgE or IgE mediated allergy, and gender were factors that influenced the development of tolerance in our study. Age at diagnosis and having a single or multiple food allergies did not impact the tolerance status. The prognosis for CMA remains favorable. The use of the milk ladder in managing CMA is an important approach for promoting early tolerance.
{"title":"What is the tolerance age of patients with cow's milk protein allergy? What are the parameters that can predict its persistence?","authors":"G. Atakul, S. Al, Özge Atay, Özge Kangallı Boyacıoğlu, S. Asilsoy, N. Uzuner","doi":"10.36472/msd.v10i8.1022","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1022","url":null,"abstract":"Objective: Cow’s milk allergy (CMA) is one of the most common food allergies in infants. The natural history of CMA indicates that resolution is common. Some studies suggest that food allergies are now being resolved at an older age. The aim of this study was to investigate the tolerance and persistence characteristics, as well as the timing of tolerance, in our own CMA patients.\u0000Material and Methods: Patients who were diagnosed with CMA and followed up in our pediatric immunology and allergy outpatient clinic between 2016-2021 years were evaluated retrospectively. Patients’ demographic characteristics, laboratory results, and tolerance time were recorded.\u0000Results: The 632 patients’ files were reviewed. 192 (30%) of the patients were followed for more than two years. The tolerance to baked products was observed with a median of 14 months, while the tolerance to fermented products was observed with a median of 17 months. Full tolerance was observed with a median of 25 months. The number of patients older than 2 years of age who could not consume any milk protein-containing product was 72 (11.4%) and 56 (77.7%) of them were IgE mediated CMA. The rate of girls with tolerance (43.5%) was found to be significantly higher than nontolerant girls (25%) (p=0.001). The mean skin test diameter of the tolerant group was significantly higher than the mean of the non-tolerant group (p=0.022). The percentage of eosinophils (p=0.003) and total IgE level (p=0.004) in the tolerant group were significantly lower compared to the intolerant group. There was no significant difference between the presence of tolerance in terms of allergy number, eosinophil count and specific IgE count (p>0.05).\u0000Conclusion: Identifying the factors influencing tolerance can lead to changes in the management of the disease. We observed that 88.6% of patients older than 2 years were tolerant to milk proteins, and all patients with non-IgE mediated CMA achieved tolerance by 2 years of age. The ratio of total IgE to specific IgE, age, total IgE and specific IgE levels, presence of non-IgE or IgE mediated allergy, and gender were factors that influenced the development of tolerance in our study. Age at diagnosis and having a single or multiple food allergies did not impact the tolerance status. The prognosis for CMA remains favorable. The use of the milk ladder in managing CMA is an important approach for promoting early tolerance.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75156639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Previous studies have shown that the presence of chronic obstructive pulmonary disease (COPD) has an effect on negative mortality and morbidity in transcatheter aortic valve implantation (TAVI) patients, the effect of systolic pulmonary artery pressure (sPAP) on long-term mortality in these patients has not been investigated. In this study, we planned to investigate the effect of sPAP on long-term mortality in patients with known COPD who were scheduled for TAVI. Methods: In this retrospective study, a total of 72 patients diagnosed with COPD and undergoing TAVI were included. Patients were divided into 2 groups based on their baseline sPAP values as for both cut off values of 34 mmhg 46 mmhg respectively [normal (sPAP <34 mmHg) and moderate-to-severe (sPAP ≥34 mmHg); 46 mmhg the cut-off value defined as the predictive value of mortality with the roc curve]. Transthoracic echocardiography parameters were used for sPAP evaluation. The primary endpoint was determined as 5-year mortality. Results: When comparing the groups based on their 5-year mortality, it was observed that sPAP values were significantly higher in the mortality group (p < 0.001). In addition, when patients were classified according to sPAP groups, 5-year mortality was found to be significantly higher in patients with sPAP ≥34 mmHg (<0.001) and sPAP ≥46 mmHg (p<0.001). Conclusion: The most significant outcome derived from our study is that elevated sPAP values measured solely through echocardiography serve as a crucial indicator of in-hospital and 5-year mortality risk among TAVI patients previously diagnosed with COPD.
{"title":"Effects of Systolic Pulmonary Arterial Pressure on Long-Term Mortality in Patients with Chronic Obstructive Pulmonary Disease and TAVI","authors":"Ö. Demir","doi":"10.36472/msd.v10i8.1024","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1024","url":null,"abstract":"Objective: Previous studies have shown that the presence of chronic obstructive pulmonary disease (COPD) has an effect on negative mortality and morbidity in transcatheter aortic valve implantation (TAVI) patients, the effect of systolic pulmonary artery pressure (sPAP) on long-term mortality in these patients has not been investigated. In this study, we planned to investigate the effect of sPAP on long-term mortality in patients with known COPD who were scheduled for TAVI.\u0000Methods: In this retrospective study, a total of 72 patients diagnosed with COPD and undergoing TAVI were included. Patients were divided into 2 groups based on their baseline sPAP values as for both cut off values of 34 mmhg 46 mmhg respectively [normal (sPAP <34 mmHg) and moderate-to-severe (sPAP ≥34 mmHg); 46 mmhg the cut-off value defined as the predictive value of mortality with the roc curve]. Transthoracic echocardiography parameters were used for sPAP evaluation. The primary endpoint was determined as 5-year mortality.\u0000Results: When comparing the groups based on their 5-year mortality, it was observed that sPAP values were significantly higher in the mortality group (p < 0.001). In addition, when patients were classified according to sPAP groups, 5-year mortality was found to be significantly higher in patients with sPAP ≥34 mmHg (<0.001) and sPAP ≥46 mmHg (p<0.001).\u0000Conclusion: The most significant outcome derived from our study is that elevated sPAP values measured solely through echocardiography serve as a crucial indicator of in-hospital and 5-year mortality risk among TAVI patients previously diagnosed with COPD.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84969890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Thyroid hormones have an important role in the cardiovascular system function. As maintaining cardiovascular homeostasis, even small fluctuations in thyroid hormone levels can increase cardiovascular-related mortality. This study aims to investigate the correlation between thyroid hormone disorders and mortality among patients admitted to the emergency department with chest pain and diagnosed with myocardial infarction. Material and Methods: The primary objective of this retrospective study was to evaluate individuals who were admitted to the emergency department and diagnosed with acute myocardial infarction, focusing specifically on patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (non-STEMI). The study comprised a total of 70 patients who were enrolled as participants and various parameters including age, gender, medical history of chronic diseases, routine blood parameters, LDL cholesterol, HDL cholesterol, triglyceride levels, as well as measurements of free T3, free T4, and TSH were recorded. Additionally, diagnoses, discharge status, and in-hospital mortality were documented. The relationship between the mortality status of the patients and the observed changes in the current thyroid function tests was evaluated. Results: The study encompassed a cohort of patients with a mean age of 64.46 ± 15.64 years (minimum: 29, maximum: 92), of which 22 individuals (31.4%) were female, and 48 (68.6%) were male. While no significant difference was found in the comparison of laboratory mean values of the patients included in the study by gender (p > 0.05), the difference between fT3, Htc and Hemoglobin values between the mortality group and the survival group was statistically significant (p < 0.05). Conclusion: Thyroid hormone disorders pose risks related to coronary artery disease, encompassing hypertension, atherosclerosis, lipid metabolism, homocysteine production, and endothelial effects, which can amplify mortality rates among acute myocardial infarction patients. The "low T3 syndrome" denotes an imbalance of thyroid hormones that significantly impacts cardiovascular mechanisms. Aberrant thyroid hormone levels exhibit a higher prevalence within acute coronary syndromes.
{"title":"Thyroid hormone profile in patients diagnosed with acute myocardial infarction and its relation with mortality","authors":"E. Dal, H. Topacoglu","doi":"10.36472/msd.v10i8.1020","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1020","url":null,"abstract":"Objective: Thyroid hormones have an important role in the cardiovascular system function. As maintaining cardiovascular homeostasis, even small fluctuations in thyroid hormone levels can increase cardiovascular-related mortality. This study aims to investigate the correlation between thyroid hormone disorders and mortality among patients admitted to the emergency department with chest pain and diagnosed with myocardial infarction.\u0000Material and Methods: The primary objective of this retrospective study was to evaluate individuals who were admitted to the emergency department and diagnosed with acute myocardial infarction, focusing specifically on patients with ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (non-STEMI). The study comprised a total of 70 patients who were enrolled as participants and various parameters including age, gender, medical history of chronic diseases, routine blood parameters, LDL cholesterol, HDL cholesterol, triglyceride levels, as well as measurements of free T3, free T4, and TSH were recorded. Additionally, diagnoses, discharge status, and in-hospital mortality were documented. The relationship between the mortality status of the patients and the observed changes in the current thyroid function tests was evaluated.\u0000Results: The study encompassed a cohort of patients with a mean age of 64.46 ± 15.64 years (minimum: 29, maximum: 92), of which 22 individuals (31.4%) were female, and 48 (68.6%) were male. While no significant difference was found in the comparison of laboratory mean values of the patients included in the study by gender (p > 0.05), the difference between fT3, Htc and Hemoglobin values between the mortality group and the survival group was statistically significant (p < 0.05).\u0000Conclusion: Thyroid hormone disorders pose risks related to coronary artery disease, encompassing hypertension, atherosclerosis, lipid metabolism, homocysteine production, and endothelial effects, which can amplify mortality rates among acute myocardial infarction patients. The \"low T3 syndrome\" denotes an imbalance of thyroid hormones that significantly impacts cardiovascular mechanisms. Aberrant thyroid hormone levels exhibit a higher prevalence within acute coronary syndromes.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84765623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study presents a comprehensive investigation of the demographic data, institutional affiliations, pre-operative evaluations, pre-medication preferences, and induction practices of anesthesiologists in Turkey. This study aimed to examine the implementation of these elements and how they reflect on the attitudes and behaviors of Turkish anesthesiologists, particularly in relation to pre-medication. Methods: This study, conducted between 16.06.2012 and 16.06.2013, utilized an electronic questionnaire distributed to practising anesthesiologists nationwide after approval from the Çanakkale 18 Mart University Clinical Research Ethics Committee. The questionnaire was divided into five sections, encompassing 26 questions addressing demographics, institutional information, pre-anaesthetic assessment data, pre-medication data, and induction data. Results: The survey gathered responses from 419 anesthesiologists across Turkey. Our findings indicated that pre-anaesthetic evaluations were predominantly conducted 2-7 days before elective surgery. There were significant variations in the pre-operative evaluations based on the type of institution, with private sector hospitals being less likely to have a dedicated room for pre-anaesthetic evaluation. The study also revealed differences in pre-medication preferences based on sex and age groups, with midazolam, ketamine, and atropine being the most preferred agents. Interestingly, the location of pre-medication administration varied significantly between private and university hospitals. The predominant motivation for pre-medication was a reduction in patient anxiety. Pediatric anesthesia induction was primarily conducted without the presence of family members, and volatile anesthetic agents were the preferred option. The route of pre-medication administration varied with age, with oral pre-medication being more common in pediatric patients, and intravenous administration being preferred in adults. Concerns about respiratory depression were prevalent after pre-medication. Conclusion: This study emphasizes that pre-operative evaluation and pre-medication are routinely carried out by anesthesiologists in Turkey, although with variations among different types of hospitals. Given the patient safety implications and importance of standardization, this study underscores the need for regular similar surveys to monitor trends and inform practice guidelines.
{"title":"Pre-medication Attitudes of Anesthesiologists: A Nationwide Survey Study from Turkey","authors":"Serpil Ekin, M. Erbaş, H. A. Kiraz, V. Hancı","doi":"10.36472/msd.v10i8.993","DOIUrl":"https://doi.org/10.36472/msd.v10i8.993","url":null,"abstract":"Objective: This study presents a comprehensive investigation of the demographic data, institutional affiliations, pre-operative evaluations, pre-medication preferences, and induction practices of anesthesiologists in Turkey. This study aimed to examine the implementation of these elements and how they reflect on the attitudes and behaviors of Turkish anesthesiologists, particularly in relation to pre-medication.\u0000Methods: This study, conducted between 16.06.2012 and 16.06.2013, utilized an electronic questionnaire distributed to practising anesthesiologists nationwide after approval from the Çanakkale 18 Mart University Clinical Research Ethics Committee. The questionnaire was divided into five sections, encompassing 26 questions addressing demographics, institutional information, pre-anaesthetic assessment data, pre-medication data, and induction data.\u0000Results: The survey gathered responses from 419 anesthesiologists across Turkey. Our findings indicated that pre-anaesthetic evaluations were predominantly conducted 2-7 days before elective surgery. There were significant variations in the pre-operative evaluations based on the type of institution, with private sector hospitals being less likely to have a dedicated room for pre-anaesthetic evaluation. The study also revealed differences in pre-medication preferences based on sex and age groups, with midazolam, ketamine, and atropine being the most preferred agents. Interestingly, the location of pre-medication administration varied significantly between private and university hospitals. The predominant motivation for pre-medication was a reduction in patient anxiety. Pediatric anesthesia induction was primarily conducted without the presence of family members, and volatile anesthetic agents were the preferred option. The route of pre-medication administration varied with age, with oral pre-medication being more common in pediatric patients, and intravenous administration being preferred in adults. Concerns about respiratory depression were prevalent after pre-medication.\u0000Conclusion: This study emphasizes that pre-operative evaluation and pre-medication are routinely carried out by anesthesiologists in Turkey, although with variations among different types of hospitals. Given the patient safety implications and importance of standardization, this study underscores the need for regular similar surveys to monitor trends and inform practice guidelines.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87332122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esra Akkütük Öngel, C. Sezen, Onur Volkan Yaran, A. Sezen, Dilekhan Kizir, H. Özçelik, M. Metin
Objective: There have been studies evaluating the association between AR and COVID-19 infection, but these studies did not evaluate the sensitisation of patients. The objective of this study was to examine the impact of allergen sensitisation on the transmission of viral infections and the progression of the disease. Material and Methods: Rhinitis patients admitted to the Adult Allergy Outpatient Clinic between April and June 2021 were included in the study. Aeroallergen sensitisation and COVID-19 disease status of the patients were evaluated. Results: Data were collected from 260 patients. It was determined that 23.8% (n=62) of the patients had COVID-19 and 17.7% (n=11) had COVID-19 pneumonia. This rate was higher than the incidence of COVID-19 in the general population. The rate of COVID-19 infection was significantly higher in patients with pollen allergy compared to other groups (p=0.049). When the COVID-19 transmission periods of the patients were analysed, it was observed that 55% of them were infected between March and September in accordance with the pollen map. Patients taking steroids (INCS or ICS) did not have an increased risk of COVID infection, and concomitant asthma did not pose an increased risk. Having chronic diseases was found to be a risk factor. Conclusions: This study provides clinical evidence of an increased frequency of infection in AR patients, especially in AR patients with pollen allergy. This result is valuable as it is a data not presented in existing studies. We also think that the risk of COVID-19 increases with pollen exposure. As pollen can suppress antiviral immunity, we recommend that chronic disease groups pay special attention to prevention methods, especially when pollen and respiratory virus seasons overlap.
{"title":"The Effect of Glasgow Prognostic Score And Systemic Inflammatory Index On Mortality In Patients With Postoperative Pneumonia","authors":"Esra Akkütük Öngel, C. Sezen, Onur Volkan Yaran, A. Sezen, Dilekhan Kizir, H. Özçelik, M. Metin","doi":"10.36472/msd.v10i8.1009","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1009","url":null,"abstract":"Objective: There have been studies evaluating the association between AR and COVID-19 infection, but these studies did not evaluate the sensitisation of patients. The objective of this study was to examine the impact of allergen sensitisation on the transmission of viral infections and the progression of the disease. \u0000Material and Methods: Rhinitis patients admitted to the Adult Allergy Outpatient Clinic between April and June 2021 were included in the study. Aeroallergen sensitisation and COVID-19 disease status of the patients were evaluated.\u0000Results: Data were collected from 260 patients. It was determined that 23.8% (n=62) of the patients had COVID-19 and 17.7% (n=11) had COVID-19 pneumonia. This rate was higher than the incidence of COVID-19 in the general population. The rate of COVID-19 infection was significantly higher in patients with pollen allergy compared to other groups (p=0.049). When the COVID-19 transmission periods of the patients were analysed, it was observed that 55% of them were infected between March and September in accordance with the pollen map. Patients taking steroids (INCS or ICS) did not have an increased risk of COVID infection, and concomitant asthma did not pose an increased risk. Having chronic diseases was found to be a risk factor.\u0000Conclusions: This study provides clinical evidence of an increased frequency of infection in AR patients, especially in AR patients with pollen allergy. This result is valuable as it is a data not presented in existing studies. We also think that the risk of COVID-19 increases with pollen exposure. As pollen can suppress antiviral immunity, we recommend that chronic disease groups pay special attention to prevention methods, especially when pollen and respiratory virus seasons overlap.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90941032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: There have been studies evaluating the association between AR and COVID-19 infection, but these studies did not evaluate the sensitisation of patients. The objective of this study was to examine the impact of allergen sensitisation on the transmission of viral infections and the progression of the disease. Material and Methods: Rhinitis patients admitted to the Adult Allergy Outpatient Clinic between April and June 2021 were included in the study. Aeroallergen sensitisation and COVID-19 disease status of the patients were evaluated. Results: Data were collected from 260 patients. It was determined that 23.8% (n=62) of the patients had COVID-19 and 17.7% (n=11) had COVID-19 pneumonia. This rate was higher than the incidence of COVID-19 in the general population. The rate of COVID-19 infection was significantly higher in patients with pollen allergy compared to other groups (p=0.049). When the COVID-19 transmission periods of the patients were analysed, it was observed that 55% of them were infected between March and September in accordance with the pollen map. Patients taking steroids (INCS or ICS) did not have an increased risk of COVID infection, and concomitant asthma did not pose an increased risk. Having chronic diseases was found to be a risk factor. Conclusions: This study provides clinical evidence of an increased frequency of infection in AR patients, especially in AR patients with pollen allergy. This result is valuable as it is a data not presented in existing studies. We also think that the risk of COVID-19 increases with pollen exposure. As pollen can suppress antiviral immunity, we recommend that chronic disease groups pay special attention to prevention methods, especially when pollen and respiratory virus seasons overlap.
{"title":"The relationship between aeroallergen sensitivity variations and Covid 19 in patients with rhinitis","authors":"Buket Başa Akdoğan, S. Gültuna","doi":"10.36472/msd.v10i8.1017","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1017","url":null,"abstract":"Objective: There have been studies evaluating the association between AR and COVID-19 infection, but these studies did not evaluate the sensitisation of patients. The objective of this study was to examine the impact of allergen sensitisation on the transmission of viral infections and the progression of the disease. \u0000Material and Methods: Rhinitis patients admitted to the Adult Allergy Outpatient Clinic between April and June 2021 were included in the study. Aeroallergen sensitisation and COVID-19 disease status of the patients were evaluated.\u0000Results: Data were collected from 260 patients. It was determined that 23.8% (n=62) of the patients had COVID-19 and 17.7% (n=11) had COVID-19 pneumonia. This rate was higher than the incidence of COVID-19 in the general population. The rate of COVID-19 infection was significantly higher in patients with pollen allergy compared to other groups (p=0.049). When the COVID-19 transmission periods of the patients were analysed, it was observed that 55% of them were infected between March and September in accordance with the pollen map. Patients taking steroids (INCS or ICS) did not have an increased risk of COVID infection, and concomitant asthma did not pose an increased risk. Having chronic diseases was found to be a risk factor.\u0000Conclusions: This study provides clinical evidence of an increased frequency of infection in AR patients, especially in AR patients with pollen allergy. This result is valuable as it is a data not presented in existing studies. We also think that the risk of COVID-19 increases with pollen exposure. As pollen can suppress antiviral immunity, we recommend that chronic disease groups pay special attention to prevention methods, especially when pollen and respiratory virus seasons overlap.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84018409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In-hospital mortality for patients presenting with acute pulmonary embolism (PE) has been reported to be up to 7 times higher for patients with decreased estimated glomerular filtration rate (eGFR). Cardiopulmonary diseases and anemia are other comorbid conditions that are suggested to be prognostic parameters in acute PE. The severity of anemia in acute PE was associated with worsening survival. We aimed to investigate the effect of anemia on association of renal function with prognosis and disease severity in patients with acute PE. Patients/Methods: The retrospective study enrolled 112 consecutive patients presenting with objectively confirmed acute PE. Demographic, clinical data, comorbidities and laboratory values were recorded. GFR were estimated using the chronic kidney disease (CKD)-EPI equations. Simplified pulmonary embolism severity index (sPESI) was calculated for all patients and severe form of the disease was defined as sPESI ≥1. In hospital mortality was primer outcome. Results: In univariate analyses, age, eGFR, anemia and chronic lung disease were found to be significantly associated with in-hospital mortality and disease severity. Only age and eGFR were found to be significant prognostic factors for early mortality [1.13(1.03-1.24); p=0.007 and 0.95(0.91 0.98); p=0.007 respectively]. Conclusion: Estimated GFR is independently associated with a more severe form of the disease and increased risk of early mortality rates within 30 days in acute pulmonary embolism independent of anemia presence.
{"title":"Relation of anemia with renal function on prognosis and disease severity in patients with acute pulmonary embolism","authors":"Ö. Demir","doi":"10.36472/msd.v10i8.1018","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1018","url":null,"abstract":"Background: In-hospital mortality for patients presenting with acute pulmonary embolism (PE) has been reported to be up to 7 times higher for patients with decreased estimated glomerular filtration rate (eGFR). Cardiopulmonary diseases and anemia are other comorbid conditions that are suggested to be prognostic parameters in acute PE. The severity of anemia in acute PE was associated with worsening survival. We aimed to investigate the effect of anemia on association of renal function with prognosis and disease severity in patients with acute PE.\u0000Patients/Methods: The retrospective study enrolled 112 consecutive patients presenting with objectively confirmed acute PE. Demographic, clinical data, comorbidities and laboratory values were recorded. GFR were estimated using the chronic kidney disease (CKD)-EPI equations. Simplified pulmonary embolism severity index (sPESI) was calculated for all patients and severe form of the disease was defined as sPESI ≥1. In hospital mortality was primer outcome.\u0000Results: In univariate analyses, age, eGFR, anemia and chronic lung disease were found to be significantly associated with in-hospital mortality and disease severity. Only age and eGFR were found to be significant prognostic factors for early mortality [1.13(1.03-1.24); p=0.007 and 0.95(0.91 0.98); p=0.007 respectively].\u0000Conclusion: Estimated GFR is independently associated with a more severe form of the disease and increased risk of early mortality rates within 30 days in acute pulmonary embolism independent of anemia presence.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83726191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In this study, it was aimed to present a comprehensive summary of the scientific publications in the field of pediatrics between 1980-2022 through bibliometric analysis and to determine the contribution of Turkey's publication trends to global productivity by comparing the publication trends of the world countries and Turkey. Materials and Methods: A Web of Science (WoS) database was used to download all tagged articles in the field of pediatrics between 1980-2022. Downloaded publications were analyzed using bibliometric approaches. The literature search was conducted with the keyword "Pediatrics" in the "Research Field" category. The correlations between publication numbers and certain economic development indicators of countries worldwide were evaluated using the Spearman correlation coefficient in accordance with the data distribution. Results: In the literature review, it was determined that 459912 of the publications with 809649 were in the Article category, and there were 19476 articles in the article category in the field of pediatrics addressing Turkey. Turkish Journal of Pediatrics, Pediatrics International, Journal of Pediatric Endocrinology & Metabolism and Turkish Archives of Pediatrics were determined to be the top four journals that contributed the most to the field of Pediatrics globally. A highly significant positive correlation was found between the number of articles produced by countries in the field of pediatrics and GDP and GDP PPP (r=0.781, P<0.001; r=0.720, P<0.001). Conclusion: In this bibliometric study, a summary of 459912 articles published between 1980-2022 and 19476 articles published in Turkey was shared. Turkey's significant contribution to global productivity was found in the 8th place with 19476 articles.
目的:本研究旨在通过文献计量分析对1980-2022年间儿科领域的科学出版物进行全面总结，并通过比较世界各国和土耳其的出版趋势来确定土耳其的出版趋势对全球生产力的贡献。材料与方法:使用Web of Science (WoS)数据库下载1980-2022年间儿科领域所有带标签的文章。使用文献计量学方法分析下载的出版物。在“研究领域”分类中以“儿科学”为关键词进行文献检索。根据数据分布，采用Spearman相关系数评价出版物数量与世界各国某些经济发展指标之间的相关性。结果:在文献综述中，809649的出版物中确定有459912篇属于Article类，其中涉及土耳其儿科领域的Article类有19476篇。《Turkish Journal of Pediatrics》、《Pediatrics International》、《Journal of Pediatric endocryology & Metabolism》和《Turkish Archives of Pediatrics》被评为全球对儿科领域贡献最大的四大期刊。各国在儿科领域发表的文章数量与国内生产总值和国内生产总值PPP呈极显著正相关(r=0.781, P<0.001;r = 0.720, P < 0.001)。结论:在这项文献计量学研究中，我们总结了1980-2022年间在土耳其发表的459912篇文章和19476篇文章。土耳其对全球生产力的重大贡献排名第八，有19476篇文章。
{"title":"A Bibliometric Analysis of Publications on Pediatrics from Turkey between 1980-2022: Contribution to Global Productivity and Publication Trends","authors":"İlknur Kaba, G. Aydoğdu","doi":"10.36472/msd.v10i8.1015","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1015","url":null,"abstract":"Objective: In this study, it was aimed to present a comprehensive summary of the scientific publications in the field of pediatrics between 1980-2022 through bibliometric analysis and to determine the contribution of Turkey's publication trends to global productivity by comparing the publication trends of the world countries and Turkey.\u0000Materials and Methods: A Web of Science (WoS) database was used to download all tagged articles in the field of pediatrics between 1980-2022. Downloaded publications were analyzed using bibliometric approaches. The literature search was conducted with the keyword \"Pediatrics\" in the \"Research Field\" category. The correlations between publication numbers and certain economic development indicators of countries worldwide were evaluated using the Spearman correlation coefficient in accordance with the data distribution.\u0000Results: In the literature review, it was determined that 459912 of the publications with 809649 were in the Article category, and there were 19476 articles in the article category in the field of pediatrics addressing Turkey. Turkish Journal of Pediatrics, Pediatrics International, Journal of Pediatric Endocrinology & Metabolism and Turkish Archives of Pediatrics were determined to be the top four journals that contributed the most to the field of Pediatrics globally. A highly significant positive correlation was found between the number of articles produced by countries in the field of pediatrics and GDP and GDP PPP (r=0.781, P<0.001; r=0.720, P<0.001).\u0000Conclusion: In this bibliometric study, a summary of 459912 articles published between 1980-2022 and 19476 articles published in Turkey was shared. Turkey's significant contribution to global productivity was found in the 8th place with 19476 articles.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86043973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective:Duetoitsasymptomaticnatureandtheabsence of preventivemeasures, cytomegalovirus (CMV) infectionduringpregnancyputsthe fetus at risk of congenitalabnormalities. Thegoal of thisbibliometricanalysis is toexaminethe perinatal CMVinfectionresearchlandscapefrom 1990 to 2022. MaterialsandMethods:Thearticlesselectedfromthe Web of ScienceCore Collection underwentbibliometricanalysisusingtheVosviewertool (VOSviewer_1.6.19).Inthisstudy, theevolution of publications on congenitalCytomegalovirus, collaborationpatterns, andimportantresearchkeywordswereinvestigatedusingbibliometricmethodologies. Results: Thisstudyfocused on 873 studies on congenital CMV infection. With an H-index of 78%, theaveragenumber of citationsperarticlewas 28.62. With 66 articlesand 2,516 citations, 2020 wastheyearwiththehighestproductivity. In SCI-EXPANDED (796 records), the Web of Scienceindexdistributionshowed 91.180%. ThehighestcategorieswereImmunology (16.724%), Pediatrics (34.822%) andInfectiousDiseases (20.962%). The US rankedfirstout of 61 countrieswith 27,950% enrollment, followedbyItalyand Japan. Top authorsincludedSuresh B. Boppana, William J. Brittand Karen Fowler. Conclusion: Thisstudyilluminatesthetrajectory of research on the global research network onthisimportantpublichealthissue of perinatal CMV infectionandidentifieskeyauthors, institutions, andjournals. Thestudyfindings can helpresearchers in thisfield.
目的:妊娠期巨细胞病毒(CMV)感染由于其症状特点和缺乏预防措施，使胎儿处于先天性异常的危险中。本文献计量学分析的目的是检查1990年至2022年围产期cmv感染的研究概况。材料和方法:选取Web of ScienceCore Collection中的文章，使用vosviewertool (vosviewer1.1 .6.19)进行文献计量学分析。本研究采用文献计量学方法，对先天性巨细胞病毒相关文献的演变、合作模式和重要的研究关键词进行了研究。结果:本研究纳入873例先天性巨细胞病毒感染研究。h指数为78%，平均被引次数为28.62次。2020年有66篇文章和2516次引用，是生产率最高的一年。在SCI-EXPANDED(796条)中，Web of science的索引分布为91.180%。最高的分类是免疫学(16.724%)、儿科(34.822%)和传染病(20.962%)。美国以27950%的入学率在61个国家中排名第一，其次是意大利和日本。顶级作家包括苏雷什·b·博帕纳、威廉·j·布里特和凯伦·福勒。结论:本研究阐明了围产期巨细胞病毒感染这一重要公共卫生问题的全球研究网络的研究轨迹，并确定了关键作者、机构和期刊。研究结果可以帮助这一领域的研究人员。
{"title":"Research on perinatal Cytomegalovirusinfections: Bibliometric Analysis (1990–2022)","authors":"Ozgur Sahin","doi":"10.36472/msd.v10i8.1021","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1021","url":null,"abstract":"Objective:Duetoitsasymptomaticnatureandtheabsence of preventivemeasures, cytomegalovirus (CMV) infectionduringpregnancyputsthe fetus at risk of congenitalabnormalities. Thegoal of thisbibliometricanalysis is toexaminethe perinatal CMVinfectionresearchlandscapefrom 1990 to 2022. \u0000MaterialsandMethods:Thearticlesselectedfromthe Web of ScienceCore Collection underwentbibliometricanalysisusingtheVosviewertool (VOSviewer_1.6.19).Inthisstudy, theevolution of publications on congenitalCytomegalovirus, collaborationpatterns, andimportantresearchkeywordswereinvestigatedusingbibliometricmethodologies. \u0000Results: Thisstudyfocused on 873 studies on congenital CMV infection. With an H-index of 78%, theaveragenumber of citationsperarticlewas 28.62. With 66 articlesand 2,516 citations, 2020 wastheyearwiththehighestproductivity. In SCI-EXPANDED (796 records), the Web of Scienceindexdistributionshowed 91.180%. ThehighestcategorieswereImmunology (16.724%), Pediatrics (34.822%) andInfectiousDiseases (20.962%). The US rankedfirstout of 61 countrieswith 27,950% enrollment, followedbyItalyand Japan. Top authorsincludedSuresh B. Boppana, William J. Brittand Karen Fowler. \u0000Conclusion: Thisstudyilluminatesthetrajectory of research on the global research network onthisimportantpublichealthissue of perinatal CMV infectionandidentifieskeyauthors, institutions, andjournals. Thestudyfindings can helpresearchers in thisfield.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"276 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76607767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meryem Kocaslan Toran, Nur Yılmaz, Dilara Kabay, Handenur Bilgi, T. Dalcı
Objective: In addition to pregnancy-specific anxiety, women experience additional anxiety related to diseases or complications that occur during pregnancy. It is reported that approximately 23% of women experience generalized anxiety disorders during pregnancy, with an increased frequency of anxiety disorders, particularly in the third trimester. Material and Methods: This cross-sectional study obtained data from pregnant women who met the inclusion criteria. The data was collected through face-to-face interviews using a Demographic Information Form, State-Trait Anxiety Inventory, and Pregnancy Experience Scale (PES). The sociodemographic, clinical, and obstetric characteristics of the participants were gathered and documented through a Demographic Information Form developed by the researchers. The study was completed with a total of 358 pregnant participants. Results: The average age of the pregnant women participating in the study was 29.01 ± 5.37 years. When evaluating educational status, it was observed that 41.1% had completed high school. Regarding gestational weeks, 78.2% of the women were in the third trimester. Analysis of neurological conditions among pregnant women indicated that 74% reported experiencing migraines and headaches. The mean score for "state anxiety" was calculated as 40.33 ± 8.10, while for "trait anxiety," it was 37.79 ± 8.50. Exploring the average scores of the Pregnancy Experiences Scale (PES), the mean score for "positive frequency" was 27.28 ± 7.08, and for "negative frequency," it was 17.39 ± 5.55. Conclusion: Notably, among pregnant women with neurological disorders, the levels of state and trait anxiety displayed notable correlations with the frequency and intensity of both positive and negative pregnancy-related experiences. Recognizing and diagnosing mood and anxiety disorders early in pregnancy, particularly in the context of neurological conditions, holds significance in mitigating potential adverse impacts on both maternal and fetal well-being. Stressing the importance of appropriate interventions and care measures is pivotal in reducing these potential effects.
{"title":"Exploring Anxiety Levels and Pregnancy Experiences Among Women with Neurological Disorders: A Cross-Sectional Study","authors":"Meryem Kocaslan Toran, Nur Yılmaz, Dilara Kabay, Handenur Bilgi, T. Dalcı","doi":"10.36472/msd.v10i8.1004","DOIUrl":"https://doi.org/10.36472/msd.v10i8.1004","url":null,"abstract":"Objective: In addition to pregnancy-specific anxiety, women experience additional anxiety related to diseases or complications that occur during pregnancy. It is reported that approximately 23% of women experience generalized anxiety disorders during pregnancy, with an increased frequency of anxiety disorders, particularly in the third trimester.\u0000Material and Methods: This cross-sectional study obtained data from pregnant women who met the inclusion criteria. The data was collected through face-to-face interviews using a Demographic Information Form, State-Trait Anxiety Inventory, and Pregnancy Experience Scale (PES). The sociodemographic, clinical, and obstetric characteristics of the participants were gathered and documented through a Demographic Information Form developed by the researchers. The study was completed with a total of 358 pregnant participants.\u0000Results: The average age of the pregnant women participating in the study was 29.01 ± 5.37 years. When evaluating educational status, it was observed that 41.1% had completed high school. Regarding gestational weeks, 78.2% of the women were in the third trimester. Analysis of neurological conditions among pregnant women indicated that 74% reported experiencing migraines and headaches. The mean score for \"state anxiety\" was calculated as 40.33 ± 8.10, while for \"trait anxiety,\" it was 37.79 ± 8.50. Exploring the average scores of the Pregnancy Experiences Scale (PES), the mean score for \"positive frequency\" was 27.28 ± 7.08, and for \"negative frequency,\" it was 17.39 ± 5.55.\u0000Conclusion: Notably, among pregnant women with neurological disorders, the levels of state and trait anxiety displayed notable correlations with the frequency and intensity of both positive and negative pregnancy-related experiences. Recognizing and diagnosing mood and anxiety disorders early in pregnancy, particularly in the context of neurological conditions, holds significance in mitigating potential adverse impacts on both maternal and fetal well-being. Stressing the importance of appropriate interventions and care measures is pivotal in reducing these potential effects.","PeriodicalId":18486,"journal":{"name":"Medical Science and Discovery","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81744452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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