Background : Recently, the mucosa has attracted attention due to its large arteries and high permeability for drug delivery. Due to the anti-inflammatory effect of parsley and easy access to this plant in Iran and the fact that the adhesive mucosa film is a new method with high performance and efficiency of drug transfer, this study was done to evaluate the effect of this plant on the pharyngitis by preparing an oral adhesive mucus film from parsley plant extract and then evaluating its pharmacological properties. Materials and methods : Fast release films of parsley were made using hydroxypropyl methyl cellulosopropinyl alcohol polymers and the use of glycerin as plasticizer and casting method. Finally, the films are analyzed in terms of thickness, uniformity, amount of drug released and disintegration time with SPSS20 software. Results : No bubbles, cracks, creases or wrinkles were seen in any of the films made of HPMC and PVA polymers. The difference in thickness measured in all films was less than 5%, and the thickness of the films was the same. Therefore, the drug introduced into the formulations has been spread evenly everywhere. No trace of the film remained in the mouth and the patients had good compliance. Conclusion : Due to the rapid dissolution of the film, rapid release of the drug, ease of use and the appropriate effects of parsley in preventing inflammation, this formulation can be used for the elderly, children and those who have difficulty swallowing. Another advantage of this method is that it can reduce the metabolism of the drug in the first hepatic passage. As a result, this formulation is a good option for treating symptoms of pharyngitis.
{"title":"Preparation and pharmaceutical evaluation of Mucoadhesive Buccal film extracts of petroselinum for pharyngitis symptoms","authors":"Mohsen Alvani, Rahim Bahri Najafi, Mahboobeh Mahmood, seyed Saeed Naji Esfahani, Nilofar Fazel","doi":"10.52547/iau.32.3.256","DOIUrl":"https://doi.org/10.52547/iau.32.3.256","url":null,"abstract":"Background : Recently, the mucosa has attracted attention due to its large arteries and high permeability for drug delivery. Due to the anti-inflammatory effect of parsley and easy access to this plant in Iran and the fact that the adhesive mucosa film is a new method with high performance and efficiency of drug transfer, this study was done to evaluate the effect of this plant on the pharyngitis by preparing an oral adhesive mucus film from parsley plant extract and then evaluating its pharmacological properties. Materials and methods : Fast release films of parsley were made using hydroxypropyl methyl cellulosopropinyl alcohol polymers and the use of glycerin as plasticizer and casting method. Finally, the films are analyzed in terms of thickness, uniformity, amount of drug released and disintegration time with SPSS20 software. Results : No bubbles, cracks, creases or wrinkles were seen in any of the films made of HPMC and PVA polymers. The difference in thickness measured in all films was less than 5%, and the thickness of the films was the same. Therefore, the drug introduced into the formulations has been spread evenly everywhere. No trace of the film remained in the mouth and the patients had good compliance. Conclusion : Due to the rapid dissolution of the film, rapid release of the drug, ease of use and the appropriate effects of parsley in preventing inflammation, this formulation can be used for the elderly, children and those who have difficulty swallowing. Another advantage of this method is that it can reduce the metabolism of the drug in the first hepatic passage. As a result, this formulation is a good option for treating symptoms of pharyngitis.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85588568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : In recent years, advances in nanotechnology presents opportunities to overcome limitations in targeted drug delivery. Nano drug carriers have the ability to change the pharmacokinetics of drugs and can improve efficacy and reduce side effects. The objective of the present work is to study the interaction of Hydralazine with functionalized carbon nanotubes by performing density functional theory calculations. Materials and methods : The behavior of hydralazine molecule adsorbed onto functionalized SWCNT was examined. The calculations were performed by Gaussian 09 software, using B3LYP density functional theory at the 6-31G * level. Results : The optimized structures were used to calculate the adsorption energy, highest occupied molecular orbital (HOMO), lowest unoccupied molecular orbital (LUMO), graphs of density of states, reactivity indexes, parameters of atoms in molecules, thermodynamic properties and molecular electrostatic potential were discussed. Conclusion : Analysis of thermodynamic functions and adsorption energy showed that the complex formed is stable. Furthermore, based on the results of bonding characteristic analysis, it was observed a hydrogen bond formed between hydralazine and functionalized CNT and this type of functionalized carbon nanotube was expected to be suitable nanocarier for delivery of hydralazine to target cells. single-walled
{"title":"Investigation of hydralazine drug adsorption on functionalized single-walled carbon nanotubes by density functional theory (DFT) method","authors":"Kimia T. Maleki, S. Hamedani","doi":"10.52547/iau.32.3.272","DOIUrl":"https://doi.org/10.52547/iau.32.3.272","url":null,"abstract":"Background : In recent years, advances in nanotechnology presents opportunities to overcome limitations in targeted drug delivery. Nano drug carriers have the ability to change the pharmacokinetics of drugs and can improve efficacy and reduce side effects. The objective of the present work is to study the interaction of Hydralazine with functionalized carbon nanotubes by performing density functional theory calculations. Materials and methods : The behavior of hydralazine molecule adsorbed onto functionalized SWCNT was examined. The calculations were performed by Gaussian 09 software, using B3LYP density functional theory at the 6-31G * level. Results : The optimized structures were used to calculate the adsorption energy, highest occupied molecular orbital (HOMO), lowest unoccupied molecular orbital (LUMO), graphs of density of states, reactivity indexes, parameters of atoms in molecules, thermodynamic properties and molecular electrostatic potential were discussed. Conclusion : Analysis of thermodynamic functions and adsorption energy showed that the complex formed is stable. Furthermore, based on the results of bonding characteristic analysis, it was observed a hydrogen bond formed between hydralazine and functionalized CNT and this type of functionalized carbon nanotube was expected to be suitable nanocarier for delivery of hydralazine to target cells. single-walled","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84503160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Colorectal cancer is one of the most common types of cancer and the cause of death of a large number of patients and requires investigating the causes of the disease and adopting targeted therapies. Considering the diagnostic, therapeutic, and prognostic significance of genetic markers, in the present study BRAF-V600E gene mutation was evaluated in tissue samples of colorectal cancer patients in Iran. Materials and methods : In this study, 43 paraffin samples of colonic tissue were collected from patients with colorectal cancer and 5 tumor margin samples were collected as control. DNA was extracted after determining the percentage of tumor cells. BRAF-V600E mutation was evaluated using specific primers for mutant and normal alleles by Allele-specific PCR and also sequencing was done on samples with mutations. Results : Mean age of the patients was 53.5 years (minimum 20 and maximum 81 years) and BRAF-V600E mutation was detected in 4 samples (9.3%). Sequencing was performed on samples in which the BRAFV600E mutation was detected. Comparison of PCR results with sequencing also showed 100% agreement. In 69.77% of the samples, the tumor percentage was equal to or more than 50% and in 30.23% of the samples, the tumor percentage was less than 50%. Conclusion : Considering the diagnostic value of BRAF-V600E gene mutation in the development of treatment methods in patients with colorectal cancer, it seems that the evaluation of this mutation is a positive point in accelerating the recovery process and determining the prognosis and can be a suitable therapeutic target for patients with this mutation.
{"title":"Evaluation of BRAF-V600E gene mutation in colon tissue of patients with colorectal cancer in Iran","authors":"Kobra Farahani, Behzad Poopak, M. Ebadi, B. Roudi","doi":"10.52547/iau.32.3.303","DOIUrl":"https://doi.org/10.52547/iau.32.3.303","url":null,"abstract":"Background : Colorectal cancer is one of the most common types of cancer and the cause of death of a large number of patients and requires investigating the causes of the disease and adopting targeted therapies. Considering the diagnostic, therapeutic, and prognostic significance of genetic markers, in the present study BRAF-V600E gene mutation was evaluated in tissue samples of colorectal cancer patients in Iran. Materials and methods : In this study, 43 paraffin samples of colonic tissue were collected from patients with colorectal cancer and 5 tumor margin samples were collected as control. DNA was extracted after determining the percentage of tumor cells. BRAF-V600E mutation was evaluated using specific primers for mutant and normal alleles by Allele-specific PCR and also sequencing was done on samples with mutations. Results : Mean age of the patients was 53.5 years (minimum 20 and maximum 81 years) and BRAF-V600E mutation was detected in 4 samples (9.3%). Sequencing was performed on samples in which the BRAFV600E mutation was detected. Comparison of PCR results with sequencing also showed 100% agreement. In 69.77% of the samples, the tumor percentage was equal to or more than 50% and in 30.23% of the samples, the tumor percentage was less than 50%. Conclusion : Considering the diagnostic value of BRAF-V600E gene mutation in the development of treatment methods in patients with colorectal cancer, it seems that the evaluation of this mutation is a positive point in accelerating the recovery process and determining the prognosis and can be a suitable therapeutic target for patients with this mutation.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"206 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78492396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Ahmadi Forg, T. Nasrabadi, F. Alaee karahroudy
Background: Childhood poisoning is a global problem and one of the causes of child mortality. Among the causes of poisoning in children and adults in Iran, opioids are one of the most important factors and among them, methadone is the most common. The aim of this study was to compare the education of prevention of children's poisoning with methadone using two methods of lectures and group discussion on the awareness of mothers treated with methadone who referred to addiction treatment centers in Birjand City in 2020. Materials and methods : The present study was an interventional study with and before and after design performed on 90 mothers treated with methadone. Sampling was done by cluster random sampling in three groups of lecture, group discussion and control. Data were collected using demographic questionnaire and mothers' knowledge questionnaire and analyzed by SPSS software version 21. Results: In the lecture group education, the mean knowledge of mothers before education was 5.97 and after education was 10.57. Also, the mean knowledge of mothers in group discussion before and after education was 6.30 and 13.47, respectively. Conclusion : Group discussion training improved the awareness of methadone-treated mothers more than lecturing.
{"title":"The effect of education on the prevention of children's poisoning with methadone on the awareness of mothers treated with methadone","authors":"Fatemeh Ahmadi Forg, T. Nasrabadi, F. Alaee karahroudy","doi":"10.52547/iau.32.3.328","DOIUrl":"https://doi.org/10.52547/iau.32.3.328","url":null,"abstract":"Background: Childhood poisoning is a global problem and one of the causes of child mortality. Among the causes of poisoning in children and adults in Iran, opioids are one of the most important factors and among them, methadone is the most common. The aim of this study was to compare the education of prevention of children's poisoning with methadone using two methods of lectures and group discussion on the awareness of mothers treated with methadone who referred to addiction treatment centers in Birjand City in 2020. Materials and methods : The present study was an interventional study with and before and after design performed on 90 mothers treated with methadone. Sampling was done by cluster random sampling in three groups of lecture, group discussion and control. Data were collected using demographic questionnaire and mothers' knowledge questionnaire and analyzed by SPSS software version 21. Results: In the lecture group education, the mean knowledge of mothers before education was 5.97 and after education was 10.57. Also, the mean knowledge of mothers in group discussion before and after education was 6.30 and 13.47, respectively. Conclusion : Group discussion training improved the awareness of methadone-treated mothers more than lecturing.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86797034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Nicotine alters the expression of various genes in the heart. PINK-1(PTEN-induced kinase1) is the major regulator of cellular mitophagy. Moreover, Parkin is a protein that plays a key role in the process of ubiquitination. Also, PGC-1ὰ (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is the main regulator of mitochondrial biogenesis. On the other hand, exercise has many positive physiological effects on patients suffering from heart failure. In this study, we aimed to investigate the effect of short endurance training on the expression of parkin, PINK1 and PGC- 1ὰ genes in the heart of nicotine-sensitive rats. Materials and methods : in this study, male Wistar rats weighing approximately 180 to 200 gr were used. The animals received nicotine at dose of 0.21 mg/kg intraperitoneally. Real time PCR technique was used to evaluate the expression of genes. Results : The results showed that nicotine decreased the expression of PGC-1ὰ gene (p<0.05) and had no effect on other genes (p>0.05). Short-term endurance training slightly increased the expression of all genes that was not statistically significant. Conclusion : It seems that short-term exercise can reduce the pro–apoptotic and stimulant effects of oxidative stress induced by nicotine. In addition, long-term exercise may potentially induce a significant positive effect on mitophagy-related genes.
{"title":"The effect of short endurance training on the expression level of PINK-1, Parkin and PGC-1α in the heart of nicotine-sensitized rats","authors":"A. Lashgari, M. Azarbayjani, M. Peeri, M. Nasehi","doi":"10.52547/iau.32.3.281","DOIUrl":"https://doi.org/10.52547/iau.32.3.281","url":null,"abstract":"Background : Nicotine alters the expression of various genes in the heart. PINK-1(PTEN-induced kinase1) is the major regulator of cellular mitophagy. Moreover, Parkin is a protein that plays a key role in the process of ubiquitination. Also, PGC-1ὰ (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is the main regulator of mitochondrial biogenesis. On the other hand, exercise has many positive physiological effects on patients suffering from heart failure. In this study, we aimed to investigate the effect of short endurance training on the expression of parkin, PINK1 and PGC- 1ὰ genes in the heart of nicotine-sensitive rats. Materials and methods : in this study, male Wistar rats weighing approximately 180 to 200 gr were used. The animals received nicotine at dose of 0.21 mg/kg intraperitoneally. Real time PCR technique was used to evaluate the expression of genes. Results : The results showed that nicotine decreased the expression of PGC-1ὰ gene (p<0.05) and had no effect on other genes (p>0.05). Short-term endurance training slightly increased the expression of all genes that was not statistically significant. Conclusion : It seems that short-term exercise can reduce the pro–apoptotic and stimulant effects of oxidative stress induced by nicotine. In addition, long-term exercise may potentially induce a significant positive effect on mitophagy-related genes.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77304163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Controlling the pulmonary involvement, as one of the most common extra-articular consequences in rheumatoid arthritis (RA), can improve the life quality and survival rate of patients. This study aimed to evaluate the correlation between disease-related inflammatory factors and the severity and type of lung involvement in patients, which is a practical step toward early detection and treatment of RA-related pulmonary problems. Materials and methods : During 2016-2021, 310 RA patients with pulmonary involvement-related symptoms were studied at Booali Hospital in Tehran. During four separate visits, patients' demographic information and inflammatory factors such as anti-nuclear antibodies (ANA), rheumatoid factor (RF), and anti-cyclic citrulline antibodies (Anti-CCP) were assessed. High-resolution CT scans and chest radiographs were performed on all patients. Data were analyzed using SPSS21 software. P<0.05 was considered as the significance level. Results : Patients with and without pulmonary involvement had a mean age of 54±13 and 49±13 years, respectively. 35 patients (45.4%) had interstitial lung disease, 21 patients (27.2%) had pulmonary nodules, 3 patients (4%) had atelectasis, 11 patients (14.3%) had bronchitis, and 7 patients (9.1 %) had pulmonary fibrosis and emphysema. Correlation between anti-CCP and RF inflammatory factors and the prevalence and type of pulmonary involvement was significant (P<0.05). There was no statistically significant difference between the ANA index and demographic data among RA patients with pulmonary involvement. Conclusion : Inflammatory factors including anti-CCP and RF may help predict the severity and pulmonary complications prognosis in RA patients. Anti-nuclear Rheumatoid and involvement in
{"title":"Correlation between anti-nuclear antibodies (ANA), rheumatoid factor (RF), anti-cyclic citrullinated peptides antibodies (Anti-CCP) and percentage and type of pulmonary involvement in patients with rheumatoid arthritis, Booali Hospital Tehran (2016-2021)","authors":"M. Olya, Shahla Abolghasemi","doi":"10.52547/iau.32.3.320","DOIUrl":"https://doi.org/10.52547/iau.32.3.320","url":null,"abstract":"Background : Controlling the pulmonary involvement, as one of the most common extra-articular consequences in rheumatoid arthritis (RA), can improve the life quality and survival rate of patients. This study aimed to evaluate the correlation between disease-related inflammatory factors and the severity and type of lung involvement in patients, which is a practical step toward early detection and treatment of RA-related pulmonary problems. Materials and methods : During 2016-2021, 310 RA patients with pulmonary involvement-related symptoms were studied at Booali Hospital in Tehran. During four separate visits, patients' demographic information and inflammatory factors such as anti-nuclear antibodies (ANA), rheumatoid factor (RF), and anti-cyclic citrulline antibodies (Anti-CCP) were assessed. High-resolution CT scans and chest radiographs were performed on all patients. Data were analyzed using SPSS21 software. P<0.05 was considered as the significance level. Results : Patients with and without pulmonary involvement had a mean age of 54±13 and 49±13 years, respectively. 35 patients (45.4%) had interstitial lung disease, 21 patients (27.2%) had pulmonary nodules, 3 patients (4%) had atelectasis, 11 patients (14.3%) had bronchitis, and 7 patients (9.1 %) had pulmonary fibrosis and emphysema. Correlation between anti-CCP and RF inflammatory factors and the prevalence and type of pulmonary involvement was significant (P<0.05). There was no statistically significant difference between the ANA index and demographic data among RA patients with pulmonary involvement. Conclusion : Inflammatory factors including anti-CCP and RF may help predict the severity and pulmonary complications prognosis in RA patients. Anti-nuclear Rheumatoid and involvement in","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"241 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91447252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : Today, there are various methods to deal with anxiety caused by surgery. Peer education through interpersonal interaction improves morale and thus reduces people's anxiety and also acts as a mediator between the patient and the medical staff. Materials and methods : A total of 60 patients were selected through simple sampling method and according to the inclusion criteria and randomly divided into two groups of intervention and control. After matching the peers, the training of the intervention group members who were on the surgical list was started by one of each peer under the supervision of the researcher. The control group also benefited from routine hospital training. Data collection tools included two questionnaires, including demographic information and Spielberger anxiety scale. Data were analyzed using SPSS 24 software. Results : The results of independent t-test with a significance level of 0.05 showed that there was no significant difference between the mean of pre-training anxiety in the two groups (p= 0.82). Postoperative anxiety showed a significant difference between intervention and control groups (p<0.001). Conclusion : The results of this study indicate that peer education has a positive effect on reducing patients' anxiety. Health professionals are always looking for solutions to use and implement it to save time and costs of hospitalization and improve the quality of care services. Awareness of the importance and impact of peer education in reducing patients 'anxiety and the economics of this type of education provides the necessary conditions for the use of peers in reducing patients' problems.
{"title":"The effect of peer education on pre- and post-operative anxiety in patients with spinal stenosis referred to selected hospitals of Iran University of Medical Sciences in 2020","authors":"F. Raoufian, F. Sahbaeiroy","doi":"10.52547/iau.32.2.204","DOIUrl":"https://doi.org/10.52547/iau.32.2.204","url":null,"abstract":"Background : Today, there are various methods to deal with anxiety caused by surgery. Peer education through interpersonal interaction improves morale and thus reduces people's anxiety and also acts as a mediator between the patient and the medical staff. Materials and methods : A total of 60 patients were selected through simple sampling method and according to the inclusion criteria and randomly divided into two groups of intervention and control. After matching the peers, the training of the intervention group members who were on the surgical list was started by one of each peer under the supervision of the researcher. The control group also benefited from routine hospital training. Data collection tools included two questionnaires, including demographic information and Spielberger anxiety scale. Data were analyzed using SPSS 24 software. Results : The results of independent t-test with a significance level of 0.05 showed that there was no significant difference between the mean of pre-training anxiety in the two groups (p= 0.82). Postoperative anxiety showed a significant difference between intervention and control groups (p<0.001). Conclusion : The results of this study indicate that peer education has a positive effect on reducing patients' anxiety. Health professionals are always looking for solutions to use and implement it to save time and costs of hospitalization and improve the quality of care services. Awareness of the importance and impact of peer education in reducing patients 'anxiety and the economics of this type of education provides the necessary conditions for the use of peers in reducing patients' problems.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76984652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Ranjbar, M. Mirhashemi, Abotaleb Seadatishamir, Rozita Fakhimi Farhadi
Background : The present study was to prepare and validate character strength training package and effectiveness on assertiveness skills of adolescents. Materials and methods : This was a quasi-experimental study with a pretest-posttest design with a control group. First, the training package was prepared and validated. Once the goals were identified, appropriate content was prepared for each strength. Finally, after applying the opinion of experts, a training package was developed. Content validity index (CVI) and content validity ratio (CVR) were high for all objectives in the training protocol. Character Strength training package in the form of 12 sessions compiled 70 minutes. The statistical population included female high school students who were studying in schools in Tehran in the academic year 2020-2021. Students were selected by available sampling method and answered the assertiveness questionnaire. Among them, 30 students whose expression was a deviation below average were randomly assigned to the experimental group (n = 15) and the control group (n = 15). The Gambrill and Ritchie (1975) Expression Questionnaire was used to assess assertiveness. Results : The results of univariate analysis of covariance (ANCOVA) showed that the mean post-test scores in the experimental group were higher than the control group. Conclusion : Based our findings, it can be concluded that the prepared character strength training package had an effective role in increasing adolescents' assertiveness.
{"title":"Preparing and validating character strength training package and its effectiveness on assertiveness skills of adolescents","authors":"Z. Ranjbar, M. Mirhashemi, Abotaleb Seadatishamir, Rozita Fakhimi Farhadi","doi":"10.52547/iau.32.2.175","DOIUrl":"https://doi.org/10.52547/iau.32.2.175","url":null,"abstract":"Background : The present study was to prepare and validate character strength training package and effectiveness on assertiveness skills of adolescents. Materials and methods : This was a quasi-experimental study with a pretest-posttest design with a control group. First, the training package was prepared and validated. Once the goals were identified, appropriate content was prepared for each strength. Finally, after applying the opinion of experts, a training package was developed. Content validity index (CVI) and content validity ratio (CVR) were high for all objectives in the training protocol. Character Strength training package in the form of 12 sessions compiled 70 minutes. The statistical population included female high school students who were studying in schools in Tehran in the academic year 2020-2021. Students were selected by available sampling method and answered the assertiveness questionnaire. Among them, 30 students whose expression was a deviation below average were randomly assigned to the experimental group (n = 15) and the control group (n = 15). The Gambrill and Ritchie (1975) Expression Questionnaire was used to assess assertiveness. Results : The results of univariate analysis of covariance (ANCOVA) showed that the mean post-test scores in the experimental group were higher than the control group. Conclusion : Based our findings, it can be concluded that the prepared character strength training package had an effective role in increasing adolescents' assertiveness.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76436068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dariush Radin, M. Hamid, M. Kargar, Mojtaba Jafarinia
Background : In chronic myeloid leukemia (CML), the influence of BCR-ABL1 transcript type, Sokal risk score and smoke on disease phynotype and cytogenetic response to treatment is still unknown and arguable. The objective of this study was to determine the prognostic significance of transcript types, risk score and smoking status among patients with CML treated with different tyrosine kinase inhibitor modalities. Materials and methods : Sixty CML patients were analyzed by Multiplex RT- PCR for molecular typing and banding standard protocols to follow the cytogenetic response of medications at intervals of 3 and 6 months. Results : The most common transcript type was e14a2 (n=35, 58.3%). There was a significant difference in cumulative incidence (CI) of complete cytogenetic response (CCR) between e14a2 and e13a2 groups (P=0.04). The time to achieve CCR was shorter in e14a2 transcript (P=0.01). The risk of resistance to drug was 4 fold higher in e13a2 group compared to e14a2. No difference was observed in CI of CCR between risk score groups (P>0.05). In smoker patients with e13a2 transcript, response to drug was lower (18 fold) than to non- smokers. Conclusion : and predictive tool for response based on transcript type. The smoke in patients expressing e13a2 may be induce resistance.
{"title":"The prognostic relevance of BCR-ABL1 transcript type, Sokal score and smoke as synergestic factor with complete cytogenetic response in CML patients treated with different TKI modalities","authors":"Dariush Radin, M. Hamid, M. Kargar, Mojtaba Jafarinia","doi":"10.52547/iau.32.2.139","DOIUrl":"https://doi.org/10.52547/iau.32.2.139","url":null,"abstract":"Background : In chronic myeloid leukemia (CML), the influence of BCR-ABL1 transcript type, Sokal risk score and smoke on disease phynotype and cytogenetic response to treatment is still unknown and arguable. The objective of this study was to determine the prognostic significance of transcript types, risk score and smoking status among patients with CML treated with different tyrosine kinase inhibitor modalities. Materials and methods : Sixty CML patients were analyzed by Multiplex RT- PCR for molecular typing and banding standard protocols to follow the cytogenetic response of medications at intervals of 3 and 6 months. Results : The most common transcript type was e14a2 (n=35, 58.3%). There was a significant difference in cumulative incidence (CI) of complete cytogenetic response (CCR) between e14a2 and e13a2 groups (P=0.04). The time to achieve CCR was shorter in e14a2 transcript (P=0.01). The risk of resistance to drug was 4 fold higher in e13a2 group compared to e14a2. No difference was observed in CI of CCR between risk score groups (P>0.05). In smoker patients with e13a2 transcript, response to drug was lower (18 fold) than to non- smokers. Conclusion : and predictive tool for response based on transcript type. The smoke in patients expressing e13a2 may be induce resistance.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82911161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : One of the important and influential contexts on quality of life is gender. The aim of this study was to compare the quality of life of elderly men and women. Materials and methods : This study is a descriptive-analytical research which is based in cross-sectional order. The statistical population of this study included all elderly people over 60 years old covered by Amol city health network in the year 2017. 450 participants were selected from among the elderly people in Amol health centers. The data collection instrument was Quality of Life Questionnaire (SF-36). Central and dispersion indices, Friedman rank test and independent t-test were used to analyze the data. Results : There was a significant difference between most men and women in terms of quality of life in most of the underlying variables. But in two variables, namely lack of family custodial and others (Relief Committee, Welfare, etc.) as source of income, there was no significant difference between elderly men and women. Also in all aspects of quality of life, the difference between men and women was significant. Conclusion : According to the findings of this study, it can be said that the mean score of quality of life for the elderly men was average but this rate was lower than the average for the elderly women.
{"title":"The comparison of elderly women and men's life quality in health centers in Amol","authors":"M. Fazli, A. Kaldi, Seyedmohmmad Seyedmirzayei","doi":"10.52547/iau.32.2.215","DOIUrl":"https://doi.org/10.52547/iau.32.2.215","url":null,"abstract":"Background : One of the important and influential contexts on quality of life is gender. The aim of this study was to compare the quality of life of elderly men and women. Materials and methods : This study is a descriptive-analytical research which is based in cross-sectional order. The statistical population of this study included all elderly people over 60 years old covered by Amol city health network in the year 2017. 450 participants were selected from among the elderly people in Amol health centers. The data collection instrument was Quality of Life Questionnaire (SF-36). Central and dispersion indices, Friedman rank test and independent t-test were used to analyze the data. Results : There was a significant difference between most men and women in terms of quality of life in most of the underlying variables. But in two variables, namely lack of family custodial and others (Relief Committee, Welfare, etc.) as source of income, there was no significant difference between elderly men and women. Also in all aspects of quality of life, the difference between men and women was significant. Conclusion : According to the findings of this study, it can be said that the mean score of quality of life for the elderly men was average but this rate was lower than the average for the elderly women.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81706450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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