{"title":"The effect of gallic acid on oxidative stress parameters and hippocampal cell density in ischemia-renal reperfusion model","authors":"Hossein Roshanfekr, M. Edalatmanesh, H. Aghababa","doi":"10.52547/iau.32.4.379","DOIUrl":"https://doi.org/10.52547/iau.32.4.379","url":null,"abstract":"","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72811172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Salehi, S. Parchehbafieh, Soheila Mashoof, M. Safavi, Mehrandokht Nekavand
{"title":"Nursing students satisfaction with peer group clinical teaching","authors":"S. Salehi, S. Parchehbafieh, Soheila Mashoof, M. Safavi, Mehrandokht Nekavand","doi":"10.52547/iau.32.4.445","DOIUrl":"https://doi.org/10.52547/iau.32.4.445","url":null,"abstract":"","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82008095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roxana Peysepar, L. Ghanei, S. Ghareh, Shahla Abolghasemi, A. Meysamie, Parima Hoseini
{"title":"Comparison of FRAX and FRAX-TBS in predicting osteoprotic fracture risk in postmenopausal women","authors":"Roxana Peysepar, L. Ghanei, S. Ghareh, Shahla Abolghasemi, A. Meysamie, Parima Hoseini","doi":"10.52547/iau.32.4.409","DOIUrl":"https://doi.org/10.52547/iau.32.4.409","url":null,"abstract":"","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81176820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of propofol on hippocampal CA2 and CA3 cells in rat model of ischemic/reperfusion","authors":"Mostafa Rahchamani, Shabnam Movassaghi, Zahra Kermaniha, Zahra Nadia Sharifi","doi":"10.52547/iau.32.4.389","DOIUrl":"https://doi.org/10.52547/iau.32.4.389","url":null,"abstract":"","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86409082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Cheraghi, A. Nooraee, Marzie Havasii, S. Soltani, K. Khazaeel
Background : The COVID-19 was first reported in 2019 in Wuhan, China, and spread rapidly in China and other countries. The virus was followed by a wide range of bacterial and opportunistic fungal diseases, including fungal infections such as mucormycosis. Materials and methods : In this narrative review study, scientific databases, such as PubMed, Google Scholar and Springer were searched with the keywords, including Mucormycosis and COVID-19 in the time period between 2020 February and July 2021. 27 articles were retrieved, in which 18 articles were used in the study and 9 were excluded. Results : So far, many people with the coronavirus have been infected by black fungus in the world. Most affected people had the history of diabetes mellitus and also receiving high dose corticosteroids. Conclusion : Recently, with the outbreak of a new wave of the deadly Covid 19 virus in India, there have been many cases of mucormycosis. Mucocycosis is fatal in about 30% of cases.
{"title":"A review of the mucormycosis prevalence during the pandemic of the coronavirus (Covid-19) worldwide","authors":"J. Cheraghi, A. Nooraee, Marzie Havasii, S. Soltani, K. Khazaeel","doi":"10.52547/iau.32.3.239","DOIUrl":"https://doi.org/10.52547/iau.32.3.239","url":null,"abstract":"Background : The COVID-19 was first reported in 2019 in Wuhan, China, and spread rapidly in China and other countries. The virus was followed by a wide range of bacterial and opportunistic fungal diseases, including fungal infections such as mucormycosis. Materials and methods : In this narrative review study, scientific databases, such as PubMed, Google Scholar and Springer were searched with the keywords, including Mucormycosis and COVID-19 in the time period between 2020 February and July 2021. 27 articles were retrieved, in which 18 articles were used in the study and 9 were excluded. Results : So far, many people with the coronavirus have been infected by black fungus in the world. Most affected people had the history of diabetes mellitus and also receiving high dose corticosteroids. Conclusion : Recently, with the outbreak of a new wave of the deadly Covid 19 virus in India, there have been many cases of mucormycosis. Mucocycosis is fatal in about 30% of cases.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"1089 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77655770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Shakeri, M. Taher, AbbasAli Hossein Khanzade, Mohammad Reza Mohammadi Soleimani
Background : Childhood is the most important stage of development of every human being. One of the most common childhood disorders is oppositional defiant disorder (ODD), so the aim of this study was to review and meta-analyze the effectiveness of psychological therapies (including improving parenting styles, life skills training and Social, play and story therapy) on this disorder. Materials and methods : This meta-analysis was carried out on articles published from 2005 to 2020 in the databases of SID, Magiran, Noormags and the Comprehensive Portal of Humanities. Search on scientific databases was done with keywords related to the research topic and 74 scientific research articles with clinical trials were extracted. After removing duplicates and reviewing the quality of articles according to the Consort checklist by three psychologists and statisticians, 5 articles had necessary conditions to participate in meta-analysis. By using Random model, articles meta-analyzed at a significance level of 0.05 using 5.4 Review Manager Software. Results : Results of meta-analysis and comparing the mean difference of the scores of ODD between the intervention and control groups showed significant higher reduction of symptoms in the intervention group compared to control group in all studies. The mean difference of standardized score for all studies was 2.88 (2.36-3.40; P <0.001) that indicated the effect of psychological interventions. Conclusion : This study showed that psychological therapies (including improving parenting styles, life and social skills training, play and story therapy) are effective in reducing the symptoms of oppositional defiant disorder. Therefore, psychological therapies is useful to treat ODD.
{"title":"The eeffectiveness of psychological treatments on oppositional defiant disorder in Iran: meta-analysis","authors":"N. Shakeri, M. Taher, AbbasAli Hossein Khanzade, Mohammad Reza Mohammadi Soleimani","doi":"10.52547/iau.32.3.229","DOIUrl":"https://doi.org/10.52547/iau.32.3.229","url":null,"abstract":"Background : Childhood is the most important stage of development of every human being. One of the most common childhood disorders is oppositional defiant disorder (ODD), so the aim of this study was to review and meta-analyze the effectiveness of psychological therapies (including improving parenting styles, life skills training and Social, play and story therapy) on this disorder. Materials and methods : This meta-analysis was carried out on articles published from 2005 to 2020 in the databases of SID, Magiran, Noormags and the Comprehensive Portal of Humanities. Search on scientific databases was done with keywords related to the research topic and 74 scientific research articles with clinical trials were extracted. After removing duplicates and reviewing the quality of articles according to the Consort checklist by three psychologists and statisticians, 5 articles had necessary conditions to participate in meta-analysis. By using Random model, articles meta-analyzed at a significance level of 0.05 using 5.4 Review Manager Software. Results : Results of meta-analysis and comparing the mean difference of the scores of ODD between the intervention and control groups showed significant higher reduction of symptoms in the intervention group compared to control group in all studies. The mean difference of standardized score for all studies was 2.88 (2.36-3.40; P <0.001) that indicated the effect of psychological interventions. Conclusion : This study showed that psychological therapies (including improving parenting styles, life and social skills training, play and story therapy) are effective in reducing the symptoms of oppositional defiant disorder. Therefore, psychological therapies is useful to treat ODD.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83913310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Kazemi, A. Ghazanfari, S. Mashhadizadeh, R. Ahmadi
Background : Integrative transdiagnostic and dialectical behavioral therapy seem to affect the hope and pain perception of cancer patients. The aim of this study was to compare the effectiveness of integrated transdiagnostic therapy and dialectical behavioral therapy on hope and pain perception of cancer patients in Isfahan. Materials and methods : The method of this study was quasi-experimental with a control group. The statistical population of the study was all cancer patients in Isfahan in 1400. Of statistical population, 63 patients were selected by available sampling and randomly assigned to two experimental groups and one control group. The experimental groups were trained with specialized protocols. Data were analyzed by repeated measures analysis of variance and Bonferroni post hoc test. Results: Compared to the control group, integrated transdiagnostic and dialectical behavioral therapy resulted in improved hope and pain perception of cancer patients in the post-test (P<0.001), and these results also showed a lasting effect in the follow-up phase. The effect of integrated transdiagnostic and dialectical behavioral therapy on hope and pain perception of patients with cancer was not different in post-test and follow-up stages. Conclusion : Integrative transdiagnostic and dialectical behavioral therapy are likely to improve hope and pain perception in cancer patients.
{"title":"Comparison of the effectiveness of integrative transdiagnostic treatment and dialectical behavior therapy on hope and pain perception among cancer patients in Isfahan","authors":"E. Kazemi, A. Ghazanfari, S. Mashhadizadeh, R. Ahmadi","doi":"10.52547/iau.32.3.311","DOIUrl":"https://doi.org/10.52547/iau.32.3.311","url":null,"abstract":"Background : Integrative transdiagnostic and dialectical behavioral therapy seem to affect the hope and pain perception of cancer patients. The aim of this study was to compare the effectiveness of integrated transdiagnostic therapy and dialectical behavioral therapy on hope and pain perception of cancer patients in Isfahan. Materials and methods : The method of this study was quasi-experimental with a control group. The statistical population of the study was all cancer patients in Isfahan in 1400. Of statistical population, 63 patients were selected by available sampling and randomly assigned to two experimental groups and one control group. The experimental groups were trained with specialized protocols. Data were analyzed by repeated measures analysis of variance and Bonferroni post hoc test. Results: Compared to the control group, integrated transdiagnostic and dialectical behavioral therapy resulted in improved hope and pain perception of cancer patients in the post-test (P<0.001), and these results also showed a lasting effect in the follow-up phase. The effect of integrated transdiagnostic and dialectical behavioral therapy on hope and pain perception of patients with cancer was not different in post-test and follow-up stages. Conclusion : Integrative transdiagnostic and dialectical behavioral therapy are likely to improve hope and pain perception in cancer patients.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86667047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background : The aim of this study was to develop a stable skin emulsifier from mupirocin. Materials and methods : This study was performed in the Department of Pharmacy, Tehran University of Pharmaceutical Sciences from November 2016 to September 2015. Initially, preformulation studies were performed on mupirocin powder and a standard diagram was drawn. Next, the bases of the drug-free emulsifiers were made, their stability was investigated and the superior formulation was selected. The next step was the formulation of the emulsion containing the drug. Further studies such as determining the amount of active ingredient, releasing the drug in vitro and determining the aura of stunting were performed. Results : Emulsifier containing 940 carbomer, 5% liquid paraffin, 0.4% tween 20 and 1.1% spin 20 were selected as the top formulation. The results of stability, dispersibility and other tests were appropriate. The amount of active ingredient in the formulations was between 90 and 110%. Within 8 hours, the drug was released at approximately 85%. Rheologically, the formulation followed non-Newtonian behavior. It also showed the behavior of plastics and thixotropes. Observing the growth inhibition zone around drug-containing formulations indicateed that mupirocin was released from the emulsion base and prevented the growth of Staphylococcus aureus bacteria. Conclusion : A stable emulsion formulation can be prepared from mupirocin. It is suggested that accelerated stability studies and periodic and scale-up formulations be carried out for industrial production.
{"title":"Formulation and physicochemical control of mupirocin emulsion","authors":"Shahrzad Akbari, R. Asgharian","doi":"10.52547/iau.32.3.264","DOIUrl":"https://doi.org/10.52547/iau.32.3.264","url":null,"abstract":"Background : The aim of this study was to develop a stable skin emulsifier from mupirocin. Materials and methods : This study was performed in the Department of Pharmacy, Tehran University of Pharmaceutical Sciences from November 2016 to September 2015. Initially, preformulation studies were performed on mupirocin powder and a standard diagram was drawn. Next, the bases of the drug-free emulsifiers were made, their stability was investigated and the superior formulation was selected. The next step was the formulation of the emulsion containing the drug. Further studies such as determining the amount of active ingredient, releasing the drug in vitro and determining the aura of stunting were performed. Results : Emulsifier containing 940 carbomer, 5% liquid paraffin, 0.4% tween 20 and 1.1% spin 20 were selected as the top formulation. The results of stability, dispersibility and other tests were appropriate. The amount of active ingredient in the formulations was between 90 and 110%. Within 8 hours, the drug was released at approximately 85%. Rheologically, the formulation followed non-Newtonian behavior. It also showed the behavior of plastics and thixotropes. Observing the growth inhibition zone around drug-containing formulations indicateed that mupirocin was released from the emulsion base and prevented the growth of Staphylococcus aureus bacteria. Conclusion : A stable emulsion formulation can be prepared from mupirocin. It is suggested that accelerated stability studies and periodic and scale-up formulations be carried out for industrial production.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75442508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Razieh Raghebi, Soheila Mohammadi Safari Kuchi, M. Karimi, M. Edalatmanesh
Background : Prenatal intoxication with trimethyletin (TMT) induces widespread neuronal death in the central nervous system by inducing oxidative stress. The aim of this study was to evaluate the antioxidant effect of gallic acid (GA) on the neuronal density of the entorhinal cortex, hippocampal pyramidal cells and oxidative stress parameters in the fetal forebrain following TMT intoxication. Materials and methods : 25 pregnant Wistar female rats were randomly divided into 5 groups, including control, TMT+Saline, TMT+GA100, TMT+GA200 and TMT+GA400. To induce TMT intoxication, TMT (9 mg/kg body weight) was injected intraperitoneally into pregnant rats on embryonic day (ED) 14. From the ED12 to ED18, the treatment groups received orally GA at different doses. After fetal cesarean section on the ED21, neuronal density assessment of the entorhinal cortex, CA1 and CA3 regions of the hippocampus and forebrain level of catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) was performed by ELISA. Results : The results showed a significant increase in the activity of CAT and SOD enzymes and a significant decrease in MDA in the forebrain of GA-receiving groups compared to the TMT + Saline group. In addition, increased neuronal density was observed in the entorhinal cortex and CA1/CA3 regions of the hippocampus in the GA treated rats compared to the TMT + Saline group. Conclusion : Prenatal TMT intoxication induced oxidative stress in the fetal forebrain, causing damage to the entorhinal cortex and hippocampus of rat fetal brain. On the other hand, GA prevented and improved neuronal damage in these areas of the fetal brain.
{"title":"The effect of Gallic acid on prenatal entorhinal cortex and CA1/CA3 hippocampal areas in trimethyltin intoxication rat","authors":"Razieh Raghebi, Soheila Mohammadi Safari Kuchi, M. Karimi, M. Edalatmanesh","doi":"10.52547/iau.32.3.293","DOIUrl":"https://doi.org/10.52547/iau.32.3.293","url":null,"abstract":"Background : Prenatal intoxication with trimethyletin (TMT) induces widespread neuronal death in the central nervous system by inducing oxidative stress. The aim of this study was to evaluate the antioxidant effect of gallic acid (GA) on the neuronal density of the entorhinal cortex, hippocampal pyramidal cells and oxidative stress parameters in the fetal forebrain following TMT intoxication. Materials and methods : 25 pregnant Wistar female rats were randomly divided into 5 groups, including control, TMT+Saline, TMT+GA100, TMT+GA200 and TMT+GA400. To induce TMT intoxication, TMT (9 mg/kg body weight) was injected intraperitoneally into pregnant rats on embryonic day (ED) 14. From the ED12 to ED18, the treatment groups received orally GA at different doses. After fetal cesarean section on the ED21, neuronal density assessment of the entorhinal cortex, CA1 and CA3 regions of the hippocampus and forebrain level of catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) was performed by ELISA. Results : The results showed a significant increase in the activity of CAT and SOD enzymes and a significant decrease in MDA in the forebrain of GA-receiving groups compared to the TMT + Saline group. In addition, increased neuronal density was observed in the entorhinal cortex and CA1/CA3 regions of the hippocampus in the GA treated rats compared to the TMT + Saline group. Conclusion : Prenatal TMT intoxication induced oxidative stress in the fetal forebrain, causing damage to the entorhinal cortex and hippocampus of rat fetal brain. On the other hand, GA prevented and improved neuronal damage in these areas of the fetal brain.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91369113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Doroud, Marjan Khatami, Nasim Rahmani, M. Shahali, Ariana Alavi, M. Hedayati
Background : Interferon (IFN) are small proteins that belong to the cytokine family and may interfere with viral infections and some cancers. There are many studies focused on the PEGylated interferon’s bioactivity. In this study, we used solid lipid nanoparticles (SLNs) to produce new drug formulations, with the aim of reducing costs, increasing effectiveness, and also reducing side effects, and the biological effects of the formulation and comparing the obtained results with the interferon alpha-2b and PEGylated interferon alpha-2b. Materials and methods : In this study, we evaluateed the toxicity and bioactivity of three formulations: interferon alpha-2b, PEGylated interferon alpha-2b, and encapsulated interferon alpha-2b with solid lipid nanoparticles using the MTT method and cytopathic inhibition assay (CPE), respectively. Results : The toxic effects of interferon encapsulated solid lipid nanoparticle (SLN-INF) was comparable with interferon and PEGylated interferon. In addition, empty solid lipid nanoparticles had no toxic effects on cells. The SLN-IFN showed higher bioactivity than the other samples tested (interferon alpha-2b, PEGylated interferon alpha-2b) and maintained its bioactivity over time. Conclusion : The results of this study indicate that interferon alpha-2b conjugated with solid lipid nanoparticles is a capable formulation with sufficient bioactivity and acceptable toxicity as compared to PEGylated interferon and can be applied in clinical trials in future studies.
{"title":"Toxicity and bioactivity evaluation of interferon alpha-2b conjugated with solid lipid nanoparticles","authors":"D. Doroud, Marjan Khatami, Nasim Rahmani, M. Shahali, Ariana Alavi, M. Hedayati","doi":"10.52547/iau.32.3.246","DOIUrl":"https://doi.org/10.52547/iau.32.3.246","url":null,"abstract":"Background : Interferon (IFN) are small proteins that belong to the cytokine family and may interfere with viral infections and some cancers. There are many studies focused on the PEGylated interferon’s bioactivity. In this study, we used solid lipid nanoparticles (SLNs) to produce new drug formulations, with the aim of reducing costs, increasing effectiveness, and also reducing side effects, and the biological effects of the formulation and comparing the obtained results with the interferon alpha-2b and PEGylated interferon alpha-2b. Materials and methods : In this study, we evaluateed the toxicity and bioactivity of three formulations: interferon alpha-2b, PEGylated interferon alpha-2b, and encapsulated interferon alpha-2b with solid lipid nanoparticles using the MTT method and cytopathic inhibition assay (CPE), respectively. Results : The toxic effects of interferon encapsulated solid lipid nanoparticle (SLN-INF) was comparable with interferon and PEGylated interferon. In addition, empty solid lipid nanoparticles had no toxic effects on cells. The SLN-IFN showed higher bioactivity than the other samples tested (interferon alpha-2b, PEGylated interferon alpha-2b) and maintained its bioactivity over time. Conclusion : The results of this study indicate that interferon alpha-2b conjugated with solid lipid nanoparticles is a capable formulation with sufficient bioactivity and acceptable toxicity as compared to PEGylated interferon and can be applied in clinical trials in future studies.","PeriodicalId":18492,"journal":{"name":"MEDICAL SCIENCES JOURNAL","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74312643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：