Bojana Scepanovic, N. Andjelic, D. Ninčić, Natasa Prvulovic-Bunovic
Introduction. According to the latest data from International Agency for Research on Cancer from 2018, global burden of cancer cervical cancer is the fourth most common cancer in women worldwide. The aim of this article was to present the contributions of the new, revised 2018 International Federation of Gynecology and Obstetrics staging of carcinoma of the cervix uteri, allowing much more precise staging with the use of any imaging modalities and/or pathological findings to allocate the stage and provide more effective treatment. International Federation of Gynecology and Obstetrics staging system. The main changes in the new staging system were made in IB stage of the disease, which now includes 3 subgroups i.e. substages for every 2 cm increments in tumor size: stage IB1 (< 2 cm), stage IB2 disease (2 to < 4 cm), and stage IB3 (? 4 cm). This system also incorporates the lymph node status into stage III cervical cancer, allowing imaging and/or pathological findings of lymph nodes to the pelvic and/or para-aortic nodes to assign stage IIIC disease. Conclusion. The main goal of the new staging system revision was to improve the accuracy of staging in order to provide more refined understanding of prognostic groups and facilitate better treatment for women with invasive cervical cancer.
{"title":"Contributions of the newly revised 2018 international federation of gynecology and obstetrics staging of cervical cancer","authors":"Bojana Scepanovic, N. Andjelic, D. Ninčić, Natasa Prvulovic-Bunovic","doi":"10.2298/mpns2006158s","DOIUrl":"https://doi.org/10.2298/mpns2006158s","url":null,"abstract":"Introduction. According to the latest data from International Agency for Research on Cancer from 2018, global burden of cancer cervical cancer is the fourth most common cancer in women worldwide. The aim of this article was to present the contributions of the new, revised 2018 International Federation of Gynecology and Obstetrics staging of carcinoma of the cervix uteri, allowing much more precise staging with the use of any imaging modalities and/or pathological findings to allocate the stage and provide more effective treatment. International Federation of Gynecology and Obstetrics staging system. The main changes in the new staging system were made in IB stage of the disease, which now includes 3 subgroups i.e. substages for every 2 cm increments in tumor size: stage IB1 (< 2 cm), stage IB2 disease (2 to < 4 cm), and stage IB3 (? 4 cm). This system also incorporates the lymph node status into stage III cervical cancer, allowing imaging and/or pathological findings of lymph nodes to the pelvic and/or para-aortic nodes to assign stage IIIC disease. Conclusion. The main goal of the new staging system revision was to improve the accuracy of staging in order to provide more refined understanding of prognostic groups and facilitate better treatment for women with invasive cervical cancer.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"60 1","pages":"158-163"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76293784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Kukic, Nina Brkić-Jovanović, D. Milutinović, Tatjana Krstić, Natasa Egeljic, D. Marinković
Introduction. Social participation is a critically important aspect of life in older adults. Also, it is one of the major subjects of research in the field of aging. Old age and its implications can have both positive and negative effects on social participation in the elderly population. Older oncology patients also face additional challenges in achieving active aging and full social participation. The goal of this study was to establish the prevalence and variety of social participation of oncology patients over the age of 60, as well as to determine any possible correlation between specific demographic characteristics and social participation. Material and Methods. The study included 100 persons aged 60 to 92 treated for malignant diseases. The Maastricht social participation profile and a demographic questionnaire designed for the purpose of this study were used as research instruments. Data analysis included the t-test for independent samples, correlation analysis, linear regression analysis, and one way analysis of variance. Results. Persons over the age of sixty have a low level of social participation, particularly in the domains of contacts with friends and family. A statistically significant difference was found in social participation in regard to different demographic characteristics: type of residence (t = 6.765, p < .01) and disability (t = 5.663, p < .01), and age (R = 0.478, p < .01). There were no statistically significant differences in regard to gender, education and presence/ absence of chronic disease. Conclusion. Oncology patients over the age of 60 have a very low social participation. Considering its importance for health and quality of life in the elderly, it is crucial to develop a support system for these persons and to recognize the significance of including social support in the care of this population.
介绍。社会参与是老年人生活中一个极其重要的方面。同时，它也是老龄化领域的主要研究课题之一。老年及其影响可以对老年人口的社会参与产生积极和消极的影响。老年肿瘤患者在实现积极老龄化和充分参与社会方面也面临着额外的挑战。本研究的目的是确定60岁以上肿瘤患者社会参与的普遍性和多样性，并确定特定人口统计学特征与社会参与之间是否存在可能的相关性。材料和方法。该研究包括100名年龄在60至92岁之间接受恶性疾病治疗的人。马斯特里赫特社会参与概况和为本研究目的而设计的人口调查问卷被用作研究工具。数据分析包括独立样本t检验、相关分析、线性回归分析和单向方差分析。结果。60岁以上的人的社会参与水平较低，特别是在与朋友和家人的联系方面。不同人口统计学特征(居住类型(t = 6.765, p < 0.01)、残疾(t = 5.663, p < 0.01)和年龄(R = 0.478, p < 0.01)的社会参与差异有统计学意义。在性别、受教育程度和是否患有慢性病方面，没有统计学上的显著差异。结论。60岁以上的肿瘤患者的社会参与度非常低。考虑到它对老年人的健康和生活质量的重要性，必须为这些人建立一个支助系统，并认识到将社会支助纳入对这一人口的照顾的重要性。
{"title":"Social participation of oncology patients over 60 years of age","authors":"B. Kukic, Nina Brkić-Jovanović, D. Milutinović, Tatjana Krstić, Natasa Egeljic, D. Marinković","doi":"10.2298/mpns2006145k","DOIUrl":"https://doi.org/10.2298/mpns2006145k","url":null,"abstract":"Introduction. Social participation is a critically important aspect of life in older adults. Also, it is one of the major subjects of research in the field of aging. Old age and its implications can have both positive and negative effects on social participation in the elderly population. Older oncology patients also face additional challenges in achieving active aging and full social participation. The goal of this study was to establish the prevalence and variety of social participation of oncology patients over the age of 60, as well as to determine any possible correlation between specific demographic characteristics and social participation. Material and Methods. The study included 100 persons aged 60 to 92 treated for malignant diseases. The Maastricht social participation profile and a demographic questionnaire designed for the purpose of this study were used as research instruments. Data analysis included the t-test for independent samples, correlation analysis, linear regression analysis, and one way analysis of variance. Results. Persons over the age of sixty have a low level of social participation, particularly in the domains of contacts with friends and family. A statistically significant difference was found in social participation in regard to different demographic characteristics: type of residence (t = 6.765, p < .01) and disability (t = 5.663, p < .01), and age (R = 0.478, p < .01). There were no statistically significant differences in regard to gender, education and presence/ absence of chronic disease. Conclusion. Oncology patients over the age of 60 have a very low social participation. Considering its importance for health and quality of life in the elderly, it is crucial to develop a support system for these persons and to recognize the significance of including social support in the care of this population.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"32 1","pages":"145-151"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86181444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Matic, A. Matic, N. Vuckovic, M. Jovanović, Z. Golušin
Introduction. Hypertensive ischemic leg ulcer, also known as Martorell ulcer, is not very rare, but an under-recognized type of leg ulcer. It has specific clinical and histopathological characteristics. It occurs almost exclusively in patients with arterial hypertension. It is more common in women and in patients with type 2 diabetes. It is localized particularly in the laterodorsal distal third of the lower leg. This ulcer is extremely painful. Its clinical features may very much resemble pyoderma gangrenosum. Case Report. We are presenting a case of a 40-year-old obese male, who suffered from arterial hypertension during the past 26 years. His ulcer appeared spontaneously on the lateral aspect of the right lower leg and progressed gradually. From the very onset, the ulcer was extremely painful. At first, it was diagnosed as pyoderma gangrenosum and treated with systemic corticosteroids and immunosuppressants. Since the response to therapy was not satisfactory, the histopathology was revised and the diagnosis of hypertensive ischemic leg ulcer was made. After initial wound debridement and local negative pressure therapy, split-thickness skin grafting was performed. The pain disappeared right away almost completely and complete epithelization was achieved two weeks after skin grafting. Conclusion. It is important to consider Martorell ulcer in hypertensive patients with extremely painful ulcers of the lower leg. In order to establish the appropriate diagnosis, it is essential to take a deep skin biopsy and correlate the finding with a specific histopathological picture. It is the only way not to confuse hypertensive ischemic leg ulcer with pyoderma gangrenosum, since the management of the two conditions is completely different.
{"title":"Martorell hypertensive ischemic leg ulcer: A case report","authors":"M. Matic, A. Matic, N. Vuckovic, M. Jovanović, Z. Golušin","doi":"10.2298/mpns2006175m","DOIUrl":"https://doi.org/10.2298/mpns2006175m","url":null,"abstract":"Introduction. Hypertensive ischemic leg ulcer, also known as Martorell ulcer, is not very rare, but an under-recognized type of leg ulcer. It has specific clinical and histopathological characteristics. It occurs almost exclusively in patients with arterial hypertension. It is more common in women and in patients with type 2 diabetes. It is localized particularly in the laterodorsal distal third of the lower leg. This ulcer is extremely painful. Its clinical features may very much resemble pyoderma gangrenosum. Case Report. We are presenting a case of a 40-year-old obese male, who suffered from arterial hypertension during the past 26 years. His ulcer appeared spontaneously on the lateral aspect of the right lower leg and progressed gradually. From the very onset, the ulcer was extremely painful. At first, it was diagnosed as pyoderma gangrenosum and treated with systemic corticosteroids and immunosuppressants. Since the response to therapy was not satisfactory, the histopathology was revised and the diagnosis of hypertensive ischemic leg ulcer was made. After initial wound debridement and local negative pressure therapy, split-thickness skin grafting was performed. The pain disappeared right away almost completely and complete epithelization was achieved two weeks after skin grafting. Conclusion. It is important to consider Martorell ulcer in hypertensive patients with extremely painful ulcers of the lower leg. In order to establish the appropriate diagnosis, it is essential to take a deep skin biopsy and correlate the finding with a specific histopathological picture. It is the only way not to confuse hypertensive ischemic leg ulcer with pyoderma gangrenosum, since the management of the two conditions is completely different.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"480 1","pages":"175-179"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83168242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Branislava Baturan, A. Krsman, D. Petrovic, S. Bulatović, D. Stajic, J. Vuković
Introduction. Rupture of an unscarred uterus is extremely rare and associated with severe maternal and fetal morbidity. Risk factors are second-stage dystocia, grand multiparity, high parity, labor induction or augmentation with oxytocin or prostaglandins, delivery after the 42nd week of gestation, neglected labor, fetal malpresentation, breech extraction, and instrumental delivery. Case Report. A 44-year-old multipara (gravid3 para3) underwent induction of labour at 40 + 3 weeks of gestation. The patient?s medical history showed no uterine surgeries, but her first delivery was instrumental, with vacuum extractor. The induction of labour was initiated by oxytocin infusion of 6 mIU/min. Continuous fetal heart rate monitoring was performed and there were no signs of fetal distress. Fetal descent in the second stage of labor lasted an hour, which is slightly over than average duration for multiparas. A live female infant weighing 3380 g was born and the pediatrician started resuscitation of the baby. Apgar score was 1/3/3. Ten days following the delivery, the patient was admitted to Emergency Gynaecology Department of the Clinic of Gynecology and Obstetrics due to abdominal pain, left sided retrouterine hematoma, and foulsmelling vaginal discharge. Laparotomy was indicated due to suspected uterine rupture. The intraoperative findings showed subinvolution of the uterus with signs of panmetritis and on the left side below the round ligament there was a 2 cm long rupture, passing through and invading the lateral and posterior walls of the uterus. A total abdominal hysterectomy with bilateral salpingo-oophorectomy on the left side was performed. Conclusion. Although a reliable prediction and prevention do not exist, the obstetricians? awareness of this rare event in unscarred uterus may decrease maternal and neonatal morbidity. This case report is an example of a serious and difficult outcome after a seemingly low-risk situation.
{"title":"Rupture of an unscarred uterus - a case report","authors":"Branislava Baturan, A. Krsman, D. Petrovic, S. Bulatović, D. Stajic, J. Vuković","doi":"10.2298/mpns2004104b","DOIUrl":"https://doi.org/10.2298/mpns2004104b","url":null,"abstract":"Introduction. Rupture of an unscarred uterus is extremely rare and associated with severe maternal and fetal morbidity. Risk factors are second-stage dystocia, grand multiparity, high parity, labor induction or augmentation with oxytocin or prostaglandins, delivery after the 42nd week of gestation, neglected labor, fetal malpresentation, breech extraction, and instrumental delivery. Case Report. A 44-year-old multipara (gravid3 para3) underwent induction of labour at 40 + 3 weeks of gestation. The patient?s medical history showed no uterine surgeries, but her first delivery was instrumental, with vacuum extractor. The induction of labour was initiated by oxytocin infusion of 6 mIU/min. Continuous fetal heart rate monitoring was performed and there were no signs of fetal distress. Fetal descent in the second stage of labor lasted an hour, which is slightly over than average duration for multiparas. A live female infant weighing 3380 g was born and the pediatrician started resuscitation of the baby. Apgar score was 1/3/3. Ten days following the delivery, the patient was admitted to Emergency Gynaecology Department of the Clinic of Gynecology and Obstetrics due to abdominal pain, left sided retrouterine hematoma, and foulsmelling vaginal discharge. Laparotomy was indicated due to suspected uterine rupture. The intraoperative findings showed subinvolution of the uterus with signs of panmetritis and on the left side below the round ligament there was a 2 cm long rupture, passing through and invading the lateral and posterior walls of the uterus. A total abdominal hysterectomy with bilateral salpingo-oophorectomy on the left side was performed. Conclusion. Although a reliable prediction and prevention do not exist, the obstetricians? awareness of this rare event in unscarred uterus may decrease maternal and neonatal morbidity. This case report is an example of a serious and difficult outcome after a seemingly low-risk situation.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"73 1","pages":"104-107"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78525644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Petrović, N. Andjelic, M. Popović, B. Nikolin, Natasa Prvulovic-Bunovic
Introduction. Undifferentiated pleomorphic sarcoma, previously known as malignant fibrous histiocytoma, is the most common soft tissue sarcoma in adults, and retroperitoneum is the second most common location. Case Report. We present a case of a 60-year-old female patient with a painless mass in the left hemiabdomen. Computed tomography revealed a well defined retroperitoneal mass, while magnetic resonance showed a lobulated hypointense mass on T1-weighted and heterogeneous on T2-weighted images 180 x 230 x 250 mm in size, with intense peripheral enhancement. The patient underwent complete tumor excision, as well as reoperation after local recurrence. After histopathological and immunohistochemical analysis of the operating material, the diagnosis of malignant fibrous histiocytoma (giant cell type) was made. Conclusion. Radiological imaging has a limited diagnostic accuracy in undifferentiated pleomorphic sarcomas and definitive diagnosis relies on histopathological confirmation.
介绍。未分化多形性肉瘤，以前称为恶性纤维组织细胞瘤，是成人中最常见的软组织肉瘤，腹膜后是第二常见的位置。病例报告。我们提出一个病例60岁的女性患者的无痛性肿块在左腹部。计算机断层扫描显示清晰的腹膜后肿块，而磁共振在t1加权上显示分叶状低密度肿块，t2加权上显示不均匀肿块，大小为180 x 230 x 250 mm，周围增强强烈。患者全部切除肿瘤，局部复发后再次手术。经手术材料的组织病理学和免疫组织化学分析，诊断为恶性纤维组织细胞瘤(巨细胞型)。结论。影像学对未分化多形性肉瘤的诊断准确性有限，最终诊断依赖于组织病理学证实。
{"title":"Undifferentiated pleomorphic retroperitoneal sarcoma: A case report","authors":"S. Petrović, N. Andjelic, M. Popović, B. Nikolin, Natasa Prvulovic-Bunovic","doi":"10.2298/mpns2006183p","DOIUrl":"https://doi.org/10.2298/mpns2006183p","url":null,"abstract":"Introduction. Undifferentiated pleomorphic sarcoma, previously known as malignant fibrous histiocytoma, is the most common soft tissue sarcoma in adults, and retroperitoneum is the second most common location. Case Report. We present a case of a 60-year-old female patient with a painless mass in the left hemiabdomen. Computed tomography revealed a well defined retroperitoneal mass, while magnetic resonance showed a lobulated hypointense mass on T1-weighted and heterogeneous on T2-weighted images 180 x 230 x 250 mm in size, with intense peripheral enhancement. The patient underwent complete tumor excision, as well as reoperation after local recurrence. After histopathological and immunohistochemical analysis of the operating material, the diagnosis of malignant fibrous histiocytoma (giant cell type) was made. Conclusion. Radiological imaging has a limited diagnostic accuracy in undifferentiated pleomorphic sarcomas and definitive diagnosis relies on histopathological confirmation.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"122 1","pages":"183-187"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89064608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-03DOI: 10.1002/9781119414612.ch53
R. Sverer
Yazışma adresi: Dr. Ogül Leman Tunar Yeditepe Üniversitesi, Diş Hekimliği Fakültesi No: 238 Bağdat Caddesi Göztepe/Kadıköy Tel: 05309233101 E-posta: ogul_leman@hotmail.com ÖZET Halitosis terimi, konuşurken veya soluma yolu ile oral kaviteden yayılan hoş olmayan ağız kokusu olarak tanımlanmaktadır. Halitosis, patolojik veya patolojik olmayan nedenlerle gelişebilen, ağız içi veya ağız dışı bir kaynaktan kötü koku yayılmasına neden olan uçucu bileşiklerin gelişmesini ifade etmektedir. 2014 yılında yapılmış olan son halitosis sınıflamasına göre 6 farklı tip belirlenmiştir. Halitosis prevelansının %22 ile %50 arasında olduğu bildirilmiş olsa da halitosis görülme sıklığı ve tedavisini içeren az sayıda çalışma olması, bu konuda yapılacak çalışmalara olan ihtiyacı ortaya koymaktadır. Bu derlemede halitosis tanımı, sınıflandırılması, etiyolojisi ve güncel tedavi yaklaşımlarına değinilmiştir. Anahtar kelimeler: Halitosis, uçucu bileşikler, tedavi seçenekleri SUMMMARY Halitosis is defined as an unpleasant odour originating from mouth during speaking or exhalation. Halitosis may be pathological or unpathological which leads to the formation of volatile compounds from an intra or extra oral source. According to a recent classification in 2014, 6 different types of halitosis have been defined. Although the prevelance of halitosis has been reported between 2250%, limited number of studies are available regarding the prevelance and treatment strategies. Therefore in this review, definition of halitosis, classification as well as the current treatment options have been disscussed.
{"title":"[Halitosis].","authors":"R. Sverer","doi":"10.1002/9781119414612.ch53","DOIUrl":"https://doi.org/10.1002/9781119414612.ch53","url":null,"abstract":"Yazışma adresi: Dr. Ogül Leman Tunar Yeditepe Üniversitesi, Diş Hekimliği Fakültesi No: 238 Bağdat Caddesi Göztepe/Kadıköy Tel: 05309233101 E-posta: ogul_leman@hotmail.com ÖZET Halitosis terimi, konuşurken veya soluma yolu ile oral kaviteden yayılan hoş olmayan ağız kokusu olarak tanımlanmaktadır. Halitosis, patolojik veya patolojik olmayan nedenlerle gelişebilen, ağız içi veya ağız dışı bir kaynaktan kötü koku yayılmasına neden olan uçucu bileşiklerin gelişmesini ifade etmektedir. 2014 yılında yapılmış olan son halitosis sınıflamasına göre 6 farklı tip belirlenmiştir. Halitosis prevelansının %22 ile %50 arasında olduğu bildirilmiş olsa da halitosis görülme sıklığı ve tedavisini içeren az sayıda çalışma olması, bu konuda yapılacak çalışmalara olan ihtiyacı ortaya koymaktadır. Bu derlemede halitosis tanımı, sınıflandırılması, etiyolojisi ve güncel tedavi yaklaşımlarına değinilmiştir. Anahtar kelimeler: Halitosis, uçucu bileşikler, tedavi seçenekleri SUMMMARY Halitosis is defined as an unpleasant odour originating from mouth during speaking or exhalation. Halitosis may be pathological or unpathological which leads to the formation of volatile compounds from an intra or extra oral source. According to a recent classification in 2014, 6 different types of halitosis have been defined. Although the prevelance of halitosis has been reported between 2250%, limited number of studies are available regarding the prevelance and treatment strategies. Therefore in this review, definition of halitosis, classification as well as the current treatment options have been disscussed.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"212 1","pages":"158-62"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76211637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Infections caused by fungi of Fusarium species occur in immunocompromised individuals as disseminated diseases. Case Report. This case report presents a 5-year-old boy with acute lymphoblastic leukemia who developed a disseminated fusarium infection during reinduction chemotherapy. Fever was the main symptom and it lasted for 15 weeks. Refractory fever despite broad-spectrum antibiotics, as well as nausea, myalgia, pulmonary symptoms with detection of pulmonary infiltrates, liver and spleen involvement indicated an invasive fungal infection. The patient received fluconazole, voriconazole, liposomal amphotericin B and caspofungin. Since high temperature was persistent, diagnostic laparoscopy of the abdomen was done. Scattered lesions, up to 2 mm in diameter, were observed macroscopically on the surface of the liver and spleen. The liver culture was positive for Acinetobacter and Fusarium species. After 38 days of therapy with liposomal amphotericin B and 3 days of ciprofloxacin, the patient became afebrile. Itraconazole (according to the antimycogram) was continued during maintenance therapy. Abdominal ultrasound was completely normal after 5 months of treatment with itraconazole. This boy was our first patient with a disseminated fusarium infection. At that time, Fusarium was detected in the hospital water system and in hospital air samples. Conclusion. A timely diagnosis of invasive fungal diseases in children is a big challenge. Over the past decade, there has been an increase in survival rate of patients with invasive fusariosis due to much more common use of voriconazole or combined antifungal therapy.
{"title":"Disseminated fusariosis in a pediatric patient with acute lymphoblastic leukemia and prolonged fever: A case report","authors":"Natasa Kacanski, B. Radisic, J. Kolarovic","doi":"10.2298/mpns1810316k","DOIUrl":"https://doi.org/10.2298/mpns1810316k","url":null,"abstract":"Introduction. Infections caused by fungi of Fusarium species occur in immunocompromised individuals as disseminated diseases. Case Report. This case report presents a 5-year-old boy with acute lymphoblastic leukemia who developed a disseminated fusarium infection during reinduction chemotherapy. Fever was the main symptom and it lasted for 15 weeks. Refractory fever despite broad-spectrum antibiotics, as well as nausea, myalgia, pulmonary symptoms with detection of pulmonary infiltrates, liver and spleen involvement indicated an invasive fungal infection. The patient received fluconazole, voriconazole, liposomal amphotericin B and caspofungin. Since high temperature was persistent, diagnostic laparoscopy of the abdomen was done. Scattered lesions, up to 2 mm in diameter, were observed macroscopically on the surface of the liver and spleen. The liver culture was positive for Acinetobacter and Fusarium species. After 38 days of therapy with liposomal amphotericin B and 3 days of ciprofloxacin, the patient became afebrile. Itraconazole (according to the antimycogram) was continued during maintenance therapy. Abdominal ultrasound was completely normal after 5 months of treatment with itraconazole. This boy was our first patient with a disseminated fusarium infection. At that time, Fusarium was detected in the hospital water system and in hospital air samples. Conclusion. A timely diagnosis of invasive fungal diseases in children is a big challenge. Over the past decade, there has been an increase in survival rate of patients with invasive fusariosis due to much more common use of voriconazole or combined antifungal therapy.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"104 19","pages":"314-318"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91408560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Zvekic-Svorcan, M. Miklós, Karmela Filipović, Milan Cvetkovic, M. Vuksanovic, J. Aleksić
Introduction. Osteoporosis is a systemic, metabolic, progressive bone disease characterized by reduced bone mineral density leading to bone fragility and reduced quality of life. The objective of this study was to examine the quality of social and mental functioning in postmenopausal women with reduced mineral bone density. Material and Methods. This prospective cross-sectional study included 210 postmenopausal women aged ≥ 50 years, who were referred for osteodensitometry to the Special Hospital for Rheumatic Diseases Novi Sad, Serbia. The study was conducted in the period from February 24 to April 3, 2017. All women completed the Serbian version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (41). They all underwent bone mineral density measurement in two regions of interest, and the results were interpreted according to the current definition of osteoporosis. The participants' social and mental functioning was analyzed including the following variables: age, place of residence, educational attainment, employment, nutritional status, bone mineral density, and low-trauma fractures. Statistical processing and analyses were performed using Statistical Package for the Social Sciences, version 20. Results. A statistically significant negative correlation was noted between social functioning and the T-score for the femoral neck (r = -0.438), hip (r = -0.412) and spine (r = -0.226), as well as mental functioning with the T-score for the femoral neck (r = -0.424), hip (r = -0.454) and spine (r = -0.319). Patients with a history of fractures had a poorer quality of social functioning (t = 2.17, p < 0.05). Conclusion. The examinees of older age, with poor socio-demographic status, reduced bone mineral density, history of low-trauma fractures presented with lower quality of social and mental functioning.
{"title":"Social and mental functioning in postmenopausal women with low bone mineral density","authors":"J. Zvekic-Svorcan, M. Miklós, Karmela Filipović, Milan Cvetkovic, M. Vuksanovic, J. Aleksić","doi":"10.2298/MPNS1806171Z","DOIUrl":"https://doi.org/10.2298/MPNS1806171Z","url":null,"abstract":"Introduction. Osteoporosis is a systemic, metabolic, progressive bone disease characterized by reduced bone mineral density leading to bone fragility and reduced quality of life. The objective of this study was to examine the quality of social and mental functioning in postmenopausal women with reduced mineral bone density. Material and Methods. This prospective cross-sectional study included 210 postmenopausal women aged ≥ 50 years, who were referred for osteodensitometry to the Special Hospital for Rheumatic Diseases Novi Sad, Serbia. The study was conducted in the period from February 24 to April 3, 2017. All women completed the Serbian version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (41). They all underwent bone mineral density measurement in two regions of interest, and the results were interpreted according to the current definition of osteoporosis. The participants' social and mental functioning was analyzed including the following variables: age, place of residence, educational attainment, employment, nutritional status, bone mineral density, and low-trauma fractures. Statistical processing and analyses were performed using Statistical Package for the Social Sciences, version 20. Results. A statistically significant negative correlation was noted between social functioning and the T-score for the femoral neck (r = -0.438), hip (r = -0.412) and spine (r = -0.226), as well as mental functioning with the T-score for the femoral neck (r = -0.424), hip (r = -0.454) and spine (r = -0.319). Patients with a history of fractures had a poorer quality of social functioning (t = 2.17, p < 0.05). Conclusion. The examinees of older age, with poor socio-demographic status, reduced bone mineral density, history of low-trauma fractures presented with lower quality of social and mental functioning.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"14 1","pages":"171-179"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74049586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ilić, I. Savić, Aleksandra Fejsa-Levakov, B. Bajkin
Introduction. Lymphomas are a group of neoplasms of the lymphatic and reticuloendothelial system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma, depending on the immunohistological characteristics of malignant lymphocytes. B-cell lymphomas are more frequent than T-cell lymphomas. In this case report we present a male patient with diffuse large B-cell lymphoma localized in the maxilla. Case Report. A 59-year-old man presented with a painless swelling in the right posterior region of the maxilla. A solid tumor was found in the right posterior maxillary region by intraoral examination, firstly suspected as a dental infection. Since the symptoms did not improve a month after the first dental treatment, he was referred for further diagnostic evaluation. The established diagnosis was diffuse large B-cell lymphoma. The patient received standard therapy for diffuse large B-cell lymphoma - rituximab-cyclophosphamide, hydroxydaunomycin, oncovin, prednisolone, six cycles and regression of the oral lesion was noticed. Conclusion. Lymphoma of the oral cavity usually presents as a swelling and may mimic odontogenic infection. Dentists should be aware of this possibility especially if the swelling is painless and if the initial treatment has failed.
{"title":"Primary diffuse large B-cell lymphoma of the oral cavity: A case report","authors":"A. Ilić, I. Savić, Aleksandra Fejsa-Levakov, B. Bajkin","doi":"10.2298/MPNS1804121I","DOIUrl":"https://doi.org/10.2298/MPNS1804121I","url":null,"abstract":"Introduction. Lymphomas are a group of neoplasms of the lymphatic and reticuloendothelial system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma, depending on the immunohistological characteristics of malignant lymphocytes. B-cell lymphomas are more frequent than T-cell lymphomas. In this case report we present a male patient with diffuse large B-cell lymphoma localized in the maxilla. Case Report. A 59-year-old man presented with a painless swelling in the right posterior region of the maxilla. A solid tumor was found in the right posterior maxillary region by intraoral examination, firstly suspected as a dental infection. Since the symptoms did not improve a month after the first dental treatment, he was referred for further diagnostic evaluation. The established diagnosis was diffuse large B-cell lymphoma. The patient received standard therapy for diffuse large B-cell lymphoma - rituximab-cyclophosphamide, hydroxydaunomycin, oncovin, prednisolone, six cycles and regression of the oral lesion was noticed. Conclusion. Lymphoma of the oral cavity usually presents as a swelling and may mimic odontogenic infection. Dentists should be aware of this possibility especially if the swelling is painless and if the initial treatment has failed.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"29 1","pages":"121-124"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78212827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milica Popovic, M. Papić, Aleksandar Acović, S. Zivanovic, T. Kanjevac
Introduction. The aim of this study was to establish the number of roots and present the root canal configuration in the maxillary and mandibular premolar teeth, and evaluate the relations among these characteristics with gender and teeth position in the Serbian population using cone-beam computed tomography. Material and Methods. Cone-beam computed tomography images of 570 teeth of 150 patients were evaluated. Teeth were classified into the following groups: maxillary first premolars, maxillary second premolars, mandibular first premolars and mandibular second premolars, and the number of roots and root canals per tooth, whereas root canal configurations were examined along with the tooth position and patients' gender. The root canal configuration was classified using Vertucci's classification. Statistical significance was obtained using Chi square test. Results. In maxillary first premolars, two roots (53.5%) and two root canals (84.5%) were the most prevalent, as well as type IV configuration (58.9%). In maxillary second premolars, most teeth had one root (88.1%) and one root canal (59.6%). In regard to gender, complex configurations with multiple canals were more prevalent in males. Higher incidence of type IV configuration in maxillary first premolars was present on the right side of the jaw (70.2%). Most mandibular first premolars had one root (98.5%). In mandibular second premolar, all teeth had one root and most had type I configuration (96.2%). Males showed higher incidence of two canals in mandibular first premolars. Conclusion. Cone-beam computed tomography is a useful tool for obtaining valuable information on root canal morphology of premolar teeth. Patient's gender should be considered when performing the preoperative assessment of endodontic treatment.
{"title":"Cone-beam computed tomography study of root number and root canal configuration of premolars in Serbian population","authors":"Milica Popovic, M. Papić, Aleksandar Acović, S. Zivanovic, T. Kanjevac","doi":"10.2298/mpns1804100p","DOIUrl":"https://doi.org/10.2298/mpns1804100p","url":null,"abstract":"Introduction. The aim of this study was to establish the number of roots and present the root canal configuration in the maxillary and mandibular premolar teeth, and evaluate the relations among these characteristics with gender and teeth position in the Serbian population using cone-beam computed tomography. Material and Methods. Cone-beam computed tomography images of 570 teeth of 150 patients were evaluated. Teeth were classified into the following groups: maxillary first premolars, maxillary second premolars, mandibular first premolars and mandibular second premolars, and the number of roots and root canals per tooth, whereas root canal configurations were examined along with the tooth position and patients' gender. The root canal configuration was classified using Vertucci's classification. Statistical significance was obtained using Chi square test. Results. In maxillary first premolars, two roots (53.5%) and two root canals (84.5%) were the most prevalent, as well as type IV configuration (58.9%). In maxillary second premolars, most teeth had one root (88.1%) and one root canal (59.6%). In regard to gender, complex configurations with multiple canals were more prevalent in males. Higher incidence of type IV configuration in maxillary first premolars was present on the right side of the jaw (70.2%). Most mandibular first premolars had one root (98.5%). In mandibular second premolar, all teeth had one root and most had type I configuration (96.2%). Males showed higher incidence of two canals in mandibular first premolars. Conclusion. Cone-beam computed tomography is a useful tool for obtaining valuable information on root canal morphology of premolar teeth. Patient's gender should be considered when performing the preoperative assessment of endodontic treatment.","PeriodicalId":18511,"journal":{"name":"Medicinski pregled","volume":"110 1","pages":"100-107"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76116262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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