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Adenocarcinoma of the appendix mimicking complicated appendicitis in the elderly : A report of two cases 老年阑尾腺癌模拟复杂阑尾炎:附2例报告
Pub Date : 2018-01-01 DOI: 10.2298/MPNS1812405C
M. Čuk, R. Gajanin, S. Djuricic, V. Marić, R. Marić, M. Kovačević
Introduction. Primary appendiceal adenocarcinoma is a very rare malignancy which accounts for 0.1% of all appendectomy specimens. In both patients presented in this paper, appendectomy was performed due to suspected acute complicated appendicitis. Case Reports. The first patient, a 77-year-old man, presented with a low grade colonic-type pT3 adenocarcinoma of the appendix, diagnosed by histopathological examination of the resected appendix delivered in a fixative. A month after appendectomy, the patient underwent right hemicolectomy of a tumor at the edge of the resection. Due to a cardiovascular disease, adjuvant chemotherapy was not indicated. The second patient, a 74-year-old female, presented with a low grade mucinous adenocarcinoma of the appendix with subserous infiltration, diagnosed by histopathological analysis of the resected appendix. Eight months after appendectomy, the patient developed a recurrent tumor in the cecal area. After radical surgical excision of the recurrent tumor, the patient received adjuvant chemotherapy. Both patients had a 5-year survival without relapse. Conclusion. Preoperative diagnosis of appendiceal adenocarcinoma is a challenge due to overlapping symptoms of complicated acute appendicitis. Our results suggest that in elderly patients with symptoms of complicated acute appendicitis, appendectomy should be done with intraoperative histopathological frozen section consultation. In advanced stages of adenocarcinoma, right hemicolectomy is a better choice than appendectomy.
介绍。原发性阑尾腺癌是一种非常罕见的恶性肿瘤,约占所有阑尾切除标本的0.1%。本文所述的两例患者均因怀疑急性复杂阑尾炎而行阑尾切除术。案例报告。第一位患者,77岁男性,表现为阑尾低级别结肠型pT3腺癌,通过对切除的阑尾进行组织病理学检查确诊。阑尾切除术后一个月,患者接受了右侧半结肠切除术边缘的肿瘤。由于心血管疾病,不需要辅助化疗。第二例患者,74岁女性,表现为阑尾低级别粘液腺癌伴浆膜下浸润,通过切除阑尾的组织病理学分析确诊。阑尾切除术后8个月,患者在盲肠区复发肿瘤。复发肿瘤根治性手术切除后,患者接受辅助化疗。两例患者均有5年生存期,无复发。结论。由于复杂急性阑尾炎的症状重叠,阑尾腺癌的术前诊断是一个挑战。我们的结果提示,对于有并发症的老年急性阑尾炎患者,阑尾切除术应在术中进行组织病理学冷冻切片会诊。在晚期腺癌中,右半结肠切除术是比阑尾切除术更好的选择。
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引用次数: 0
Outcome of cataract surgery in diabetic patients 糖尿病患者白内障手术的疗效
Pub Date : 2018-01-01 DOI: 10.2298/MPNS1808217C
V. Canadanovic, N. Babic, S. Davidović, A. Miljkovic, Stefan Brunet, S. Barišić
Introduction. The association between diabetes and cataract formation has been shown in many clinical studies. Development of cataract occurs more frequently and at an earlier age in diabetic patients. Due to the increasing prevalence of diabetes worldwide, the incidence of diabetic cataracts steadily rises. While the overall outcomes of cataract surgery are excellent, patients with diabetes may have poorer vision outcomes than those without diabetes. The objective of this study was to evaluate the visual outcomes (visual acuity and visual function), intraoperative and postoperative complications of cataract surgery, and to assess the final surgical outcomes. Material and Methods. The prospective study included 128 patients (133 eyes) with cataract and diagnosis of diabetes mellitus type 2 at least 5 years prior to cataract surgery, operated at the Eye Clinic, Clinical Center of Vojvodina, Novi Sad. A full medical history included patients' age, the time since the diagnosis of diabetes, current management of diabetes, blood pressure and assessment of glycemic control using glycosylated hemoglobin. All patients underwent complete ophthalmological examination before cataract surgery, and were re-examined 7 days, one and six months after the surgery. Results. The mean age of patients at the time of surgery was 63.5 years (SD ± 6.5, range 57 - 70 years) with mean duration of diabetes 8.5 years. The glycosylated haemoglobin level in the group treated with insulin was 6.8 vs. 8.2 in patients on oral medications (p < 0.05). Diabetes mellitus was accompanied by other systemic diseases in 81 patients (63.28%), whereas 45 of 133 operated eyes (33.83%) had other ocular diseases. Intraoperative complications occurred in 20 of 133 operated eyes (15%): posterior capsular rupture with vitreous loss, intraoperative miosis, iris hemorrhage and suprachoroidal hemorrhage. Conclusion. Cataract surgery with intraocular lens implantation is an effective and safe surgical procedure in diabetic patients, and sight threatening complications are rare. Our study confirmed that visual acuity after surgery in diabetic patients depends on the severity of diabetic retinopathy at the time of surgery.
介绍。糖尿病与白内障形成之间的关系已在许多临床研究中得到证实。糖尿病患者白内障发病更频繁,发病年龄更早。随着全球糖尿病患病率的不断上升,糖尿病性白内障的发病率也在稳步上升。虽然白内障手术的总体效果很好,但糖尿病患者的视力可能比没有糖尿病的患者差。本研究的目的是评估白内障手术的视力结果(视力和视力功能)、术中和术后并发症,并评估最终手术结果。材料和方法。这项前瞻性研究包括128例(133只眼)白内障患者,并在诺维萨德伏伊伏丁那临床中心眼科诊所进行白内障手术前至少5年诊断为2型糖尿病。完整的病史包括患者的年龄、自糖尿病诊断以来的时间、糖尿病的当前管理、血压和使用糖化血红蛋白评估血糖控制。所有患者术前均行全面眼科检查,术后7天、1个月、6个月复查。结果。患者手术时的平均年龄为63.5岁(SD±6.5,范围57 - 70岁),平均糖尿病病程8.5年。胰岛素组糖化血红蛋白水平为6.8,口服药物组为8.2 (p < 0.05)。糖尿病合并其他全身性疾病81例(63.28%),其他眼部疾病45例(33.83%)。133只手术眼中有20只(15%)出现术中并发症:后囊膜破裂伴玻璃体丢失、术中瞳孔缩小、虹膜出血和脉络膜上出血。结论。白内障手术联合人工晶状体植入术是一种有效且安全的糖尿病患者手术方法,威胁视力的并发症很少。我们的研究证实,糖尿病患者手术后的视力取决于手术时糖尿病视网膜病变的严重程度。
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引用次数: 1
Delayed splenic rupture in massive splenomegaly - a case report 脾肿大致迟发性脾破裂1例
Pub Date : 2018-01-01 DOI: 10.2298/mpns1802049p
Srđan S. Putnik, M. Ilic
Introduction. We present a patient with a delayed rupture of the spleen following a mild abdominal trauma. For years, the patient was treated for hereditary massive splenomegaly with thrombocytopenia, without established etiology. Case Report . The initial non-operative treatment lasted seven days, after which the patient was readmitted to the Emergency Department with signs of intra-abdominal hemorrhage and underwent emergency open splenectomy. Even after pathohistological examination, the etiology of massive splenomegaly remained unknown. Conclusion. Conservative treatment is not recommended in cases of massive splenomegaly; thorough surgical observation in a tertiary care hospital with interventional radiology and a good multidisciplinary team is necessary, while splenectomy is a surgery of choice.
介绍。我们提出了一个病人延迟脾破裂后,轻度腹部创伤。多年来,患者治疗遗传性脾肿大伴血小板减少症,没有明确的病因。病例报告。最初的非手术治疗持续了7天,之后患者因腹腔内出血的迹象再次被送至急诊科,并进行了紧急开腹脾切除术。即使经过病理组织学检查,脾肿大的病因仍不清楚。结论。脾肿大不建议保守治疗;在三级医院进行充分的手术观察,有介入放射学和良好的多学科团队,脾切除术是一种选择。
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引用次数: 0
Environmental noise in Novi Sad 1985 - 2016 1985 - 2016年诺维萨德的环境噪声
Pub Date : 2018-01-01 DOI: 10.2298/mpns1804137z
E. Živadinović, M. Jevtić, S. Bijelović
Introduction. Noise is recognized as a physical hazard in the environment, and if it causes adverse effects to human health, it is recognized as a risk. Also, it is a harmful outdoor sound created by human activity. The aim of this paper was to present the history of environmental noise measurements in Novi Sad, as well as the indicators, methods, standards and results during three decades. Material and Methods. From 1985 to 2011, the Institute of Public Health of Vojvodina conducted noise measurements presented as the equivalent continuous sound pressure levels, which were, at the same time, the rating equivalent continuous levels, due to the representativity of the measurement conditions and measurement sites selection. Since 2011, the measurements have included the basic noise indicators - daily, evening, night and total noise, while the measurement sites were ranked in accordance to the European Environmental Noise Directive. Results. There is a lot of available data about environmental noise in Novi Sad from 1985 - 2016, but only the data from five representative measurement sites are presented in the paper. The linear trends of daily and night noise from all the measurement sites show a fall, but it does not mean that the environmental noise is reduced. All the data show that the minimum and maximum values are getting close to each other, which indicates that environmental noise is evenly distributed and is present everywhere. Conclusion. Based on the 30 -year results, always using modern methodology and equipment, as well as expert knowledge, it may be concluded that the environmental noise in Novi Sad presents a long-lasting physical hazard.
介绍。噪音被认为是环境中的一种物理危害,如果它对人类健康造成不利影响,它就被认为是一种风险。此外,它是人类活动产生的有害的户外声音。本文的目的是介绍诺维萨德环境噪声测量的历史,以及三十年来的指标、方法、标准和结果。材料和方法。从1985年到2011年,伏伊伏丁那公共卫生研究所进行了噪声测量,表示为等效连续声压级,同时,由于测量条件的代表性和测量地点的选择,这是额定等效连续级。自2011年以来,测量包括基本的噪音指标-每日,傍晚,夜间和总噪音,而测量地点根据欧洲环境噪音指令进行排名。结果。关于诺维萨德1985 - 2016年的环境噪声有很多可用的数据,但本文只介绍了五个代表性测量点的数据。各测点昼夜噪声的线性趋势均呈下降趋势,但并不意味着环境噪声降低。所有数据表明,最小值和最大值越来越接近,表明环境噪声分布均匀,无处不在。结论。基于30年的结果,始终使用现代方法和设备,以及专家知识,可以得出结论,诺维萨德的环境噪声具有长期的物理危害。
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引用次数: 1
Effect of anticoagulant and antiplatelet therapy on the occurrence of primary intracerebral hemorrhage 抗凝、抗血小板治疗对原发性脑出血发生的影响
Pub Date : 2018-01-01 DOI: 10.2298/mpns1802042p
Aleksandra Lučić-Prokin, Armin Pakoci, S. Popovic, A. Uvelin
Introduction. The incidence of intracerebral hemorrhage related to oral anticoagulant and antiplatelet therapy has an increasing trend, thus it may be a potential indicator of unvaforable outcome of primary intracerebral hemorrhage. The aim of the study was to determine the effect of these therapies on the occurrence, localization and outcome of primary intracerebral hemorrhage. Material and Methods. A retrospective study included 246 patients with first time diagnosed primary intracerebral hemorrhage. Patients were divided into three groups, according to the drugs they have used. The incidence, anatomical distribution of primary intracerebral hemorrhage and survival/mortality rates were observed in all groups. Results. Antiplatelet therapy was used by 20.3% of patients, 8.2% received antocoagulant therapy, while the rest of 71.5% did not take these drugs in the premorbid period. The most common risk factor was arterial hypertension (97.2%). In all groups, patients had a tendency for supratentorial hematomas. Only alcohol consumption had a significant impact on the localization of hemorrhage (p < 0,05). There was no statistically significant difference between groups in National Institutes of Health Stroke Scale score on admission and a modified Rankin Scale Score at discharge. Oral anticoagulant users presented with the highest mortality rate in the first 24 hours (odds ratio - 2.5). Patients in other two groups showed a significantly higher survival rate (odds ratio - 1.5). Conclusion. Oral anticoagulant users had significantly higher National Institutes of Health Stroke Scale score on admission with an increased risk for early death. A significantly higher percentage of survival was noted in other two groups. Approximately 2/3 of all patients had poor functional recovery.
介绍。与口服抗凝、抗血小板治疗相关的脑出血发生率呈上升趋势,可能是原发性脑出血预后不可改变的潜在指标。本研究的目的是确定这些治疗方法对原发性脑出血的发生、定位和转归的影响。材料和方法。一项回顾性研究包括246例首次诊断为原发性脑出血的患者。根据患者使用的药物,他们被分为三组。观察各组原发性脑出血的发生率、解剖分布及生存/死亡率。结果。20.3%的患者使用了抗血小板治疗,8.2%的患者使用了抗凝治疗,其余71.5%的患者在发病前未使用这些药物。最常见的危险因素是动脉高血压(97.2%)。所有组患者均有幕上血肿的倾向。只有饮酒对出血的定位有显著影响(p < 0.05)。入院时美国国立卫生研究院卒中量表评分和出院时修正Rankin量表评分两组间无统计学差异。口服抗凝剂使用者在最初24小时内死亡率最高(优势比- 2.5)。其他两组患者生存率明显高于对照组(优势比- 1.5)。结论。口服抗凝血剂使用者入院时的美国国立卫生研究院卒中量表评分明显较高,早期死亡风险增加。另外两组的存活率明显更高。大约2/3的患者功能恢复较差。
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引用次数: 0
Clinical and radiographic outcomes of surgical management of chronic periapical lesions in multirooted teeth 多根牙慢性根尖周病变手术治疗的临床和影像学结果
Pub Date : 2018-01-01 DOI: 10.2298/MPNS1802009R
Igor Repic, Gordana Repić, D. Zarić, Andjelija Petrovic
Introduction. Chronic periapical lesion is a pathological process of the root apex and the surrounding alveolar bone. Granuloma, which is a term that usually describes a chronic periapical process, represents a mass of granulation tissue at the apex of a devitalized tooth. Such lesions are treated by conventional (endodontic) therapy or surgery. The aim of this study was to assess clinical and radiographic outcomes of surgical treatment of chronic periapical lesions in multirooted teeth. Material and Methods. This prospective study included 30 patients who underwent a standard Partsch surgical procedure. The root canals, without previous endodontic treatment, were obturated immediately before surgery, or intraoperatively. The canals with short fillings or teeth with fixed prosthetics were retrogradely obturated. Zinc-phosphate cement condensed with gutta-percha cone was used for obturation. Evaluation of clinical outcomes was performed 6, 12 and 24 months after surgery, and radiographic outcomes after 12 and 24 months, respectively. Results. After surgery, a statistically significant improvements of treatment outcomes were observed between the follop-ups (p < 0.000). The overall success rate of chronic periapical lesions in multirooted teeth 24 months after surgery was 83.3% for clinical and 66.7% for radiographic outcomes. Conclusion. The results of clinical and radiographic parameters after surgical treatment outcomes in multirooted teeth were satisfying. Therefore, we may conclude that surgical treatment can be considered as a primary treatment option in the management of chronic periapical lesions.
介绍。慢性根尖周病变是根尖和周围牙槽骨的病理过程。肉芽肿,这是一个术语,通常描述一个慢性的根尖周围过程,代表了大量的肉芽组织的顶端失活的牙齿。这种病变可通过常规(牙髓)治疗或手术治疗。本研究的目的是评估手术治疗多根牙慢性根尖周病变的临床和影像学结果。材料和方法。这项前瞻性研究包括30例接受标准帕氏外科手术的患者。术前或术中立即封闭根管,术前未进行根管治疗。短填充物根管或固定义齿行逆行封闭。采用聚碳酸酯胶凝磷酸锌水泥进行封堵。分别在术后6个月、12个月和24个月评估临床结果,在术后12个月和24个月评估影像学结果。结果。手术后,随访期间观察到治疗结果有统计学意义的改善(p < 0.000)。术后24个月多根牙慢性根尖周病变的临床总成功率为83.3%,影像学总成功率为66.7%。结论。多根牙术后临床及影像学指标均满意。因此,我们可以得出结论,手术治疗可以被认为是慢性根尖周围病变管理的主要治疗选择。
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引用次数: 1
The efficiency and safety of a dietary supplement used in the treatment of preschool and school children with acute respiratory infections 一种膳食补充剂用于治疗学龄前和学龄儿童急性呼吸道感染的有效性和安全性
Pub Date : 2018-01-01 DOI: 10.2298/MPNS1806180S
L. Sagić, K. Milosevic, O. Ostojić, A. Agić
Introduction. The aim of this research was to assess the efficiency and safety of a natural product N-acetylcysteine and propolis in the children with acute respiratory infections with increased mucus production and cough. Material and Methods. The research was conducted in the period April 2016 - February 2017 among 145 pediatric patients aged 3 to 14 years with symptoms of acute respiratory infection. They were divided into two groups. Group A - preschool and Group B - school children. The first clinical examination included demographic data, physical examination. filling out the quality of cough questionnaire, and taking nasal and pharyngeal swabs. After a ten-day therapy, physical examination was conducted, quality of cough questionnaire was refilled and swabs were taken. Results. Group A included 73 and Group B 72 children. No statistically significant difference was observed in the incidence of respiratory disease episodes. In Group B children received antibiotics less often. started school at an early age and more children had daily activities in regard to children in Group A. Statistically, both groups of children coughed early in the morning more than during the day. The results of control swab tests were negative in both groups. No side effects were reported in either group. Conclusion. The propolis combined with N-acetylcysteine in a pediatric syrup is a good choice in the treatment of acute respiratory infections in children with accompanied mucus production and cough. The product is efficient and safe for all age groups.
介绍。本研究的目的是评估天然产物n -乙酰半胱氨酸和蜂胶在患有急性呼吸道感染的儿童中产生粘液和咳嗽的效率和安全性。材料和方法。该研究于2016年4月至2017年2月期间对145名3至14岁的急性呼吸道感染症状的儿童患者进行了研究。他们被分成两组。A组是学龄前儿童,B组是学龄儿童。第一次临床检查包括人口统计资料、体格检查。填写咳嗽质量调查问卷,取鼻咽拭子。治疗10 d后,进行体格检查,填写咳嗽质量问卷并取拭子。结果。A组73例,B组72例。呼吸系统疾病发作的发生率无统计学差异。B组儿童较少使用抗生素。与a组的孩子相比,a组的孩子更早开始上学,并且有更多的孩子参加日常活动。统计数据显示,两组孩子在清晨咳嗽的次数都比白天多。对照组拭子试验结果均为阴性。两组均无副作用报告。结论。小儿糖浆中蜂胶联合n -乙酰半胱氨酸是治疗伴有黏液产生和咳嗽的儿童急性呼吸道感染的良好选择。该产品对所有年龄组都有效且安全。
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引用次数: 0
Spasticity - a result of central nervous system injury 痉挛-中枢神经系统损伤的结果
Pub Date : 2018-01-01 DOI: 10.2298/MPNS1802005N
N. Naumović
Introduction. Spasticity is an interrupted or constant hyperactivity of the sceletal muscles, caused by lesion of the upper motor neuron. The aim of this article was to gather scientifically and clinically important data about spasticity. Morpho-functional basis on which spasticity originates. The spasm is motoric disorder in which an increased muscle tone is present (especially of antigravity muscles), with slower movements and tendency of appearing moderate atrophy and contractures. Etiology. Spasticity may be caused by stroke; demyelinating diseases (sclerosis multiplex, amyotrophic lateral sclerosis); cerebral palsy; tumors; brain and spinal cord damage (trauma, ischemia, surgical intervention); other neurodegenerative diseases. Symptoms. There are a number of symptoms: increased muscle tone, joint stiffness, overactive reflexes, involuntary jerky movements, which may include spasms and clonus, pain, decreased functional abilities and delayed motor development, difficulty with care and hygiene, unusual posture, abnormal positioning of fingers, wrists, arms, or shoulders, contractures or muscle tightness. Management of spasticity- therapeutic treatment: physical therapy and rehabilitation, medicamentous and surgical treatment. Conclusion. Spasticity is a complex phenomenon with constant hyperactivity of the sceletal muscles, it is one component of upper motoneuron syndrome and many neurological diseases and disorders. Therapeutic treatment of spasticity should be highly specific, individualized, multidisciplinar and conducted carefully, controlled with the purpose of functional improvement and pain relief. It is significant to know that sometimes spasticity is useful and should not be removed. There is a need for standardized protocols for 'best practice' in management of spasticity.
介绍。痉挛是由上运动神经元损伤引起的一种中断的或持续的胸骼肌过度活动。本文的目的是收集有关痉挛的科学和临床重要数据。痉挛产生的形态功能基础。痉挛是一种运动障碍,表现为肌肉张力增加(尤其是反重力肌肉),运动缓慢,有出现中度萎缩和收缩的倾向。病因。痉挛可能由中风引起;脱髓鞘疾病(多发性硬化症、肌萎缩侧索硬化症);脑瘫;肿瘤;脑和脊髓损伤(创伤、缺血、手术干预);其他神经退行性疾病。症状。有许多症状:肌肉紧张度增加、关节僵硬、反射过度活跃、不自主的突然运动(可能包括痉挛和斜视)、疼痛、功能能力下降和运动发育迟缓、护理和卫生困难、不寻常的姿势、手指、手腕、手臂或肩膀的异常定位、挛缩或肌肉紧绷。痉挛的管理-治疗治疗:物理治疗和康复,药物和手术治疗。结论。痉挛是一种复杂的现象,伴有胸骼肌持续过度活动,是上运动神经元综合征和许多神经系统疾病的一个组成部分。痉挛的治疗应该是高度特异性的、个体化的、多学科的、谨慎的、以功能改善和疼痛缓解为目的的控制。重要的是要知道,有时痉挛是有用的,不应该消除。有必要为痉挛管理的“最佳实践”制定标准化的方案。
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引用次数: 0
Breastfeeding through the centuries 几个世纪以来的母乳喂养
Pub Date : 2018-01-01 DOI: 10.2298/MPNS1806151M
O. Milankov
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引用次数: 1
Influence of personal characteristics on the occurrence of lumbar pain in nurses 护士个人特征对腰痛发生的影响
Pub Date : 2018-01-01 DOI: 10.2298/MPNS18S1065B
A. Božić, I. Mikov, Djordje Gajdobranski, Branislava Brestovački-Svitlica, Zlatko Ćirić
SummaryIntroduction. Even though lumbar pain is one of the most com mon medical problems of today, it is difficult to determine its precise origin. When identifying the risk factors for developing lumbar pain, one should also take into account the personal characteristics such as gender, age, body mass index, smoking habits, physical activities etc. The basic goal of this study was to assess the relationship between the socio-demographic char acteristics (age, gender, level of education), the body mass in -dex, smoking habits, and lumbar pain in nurses. Material and Methods. This cross-sectional study was conducted in five healthcare institutions in the area of Vojvodina by interviewing nurses by means of the modified Nordic questionnaire. Results. The participants were predominantly female, the majority of them having secondary school degree. The study revealed a statistically significant relationship between lumbar pain and the increase of age and body mass index, while smoking habits did not influence the occurrence of lumbar pain. Conclusion. A better organization of work in relation to the age and gender as well body mass control would reduce the risk of lumbar pain.
SummaryIntroduction。尽管腰痛是当今最常见的医学问题之一,但很难确定其确切的起源。在确定导致腰痛的危险因素时,还应考虑到个人特征,如性别、年龄、体重指数、吸烟习惯、体育活动等。本研究的基本目的是评估护士的社会人口学特征(年龄、性别、教育水平)、体重指数、吸烟习惯和腰痛之间的关系。材料和方法。这项横断面研究是在伏伊伏丁那地区的五个保健机构进行的,通过修改北欧问卷采访护士。结果。参与者主要是女性,其中大多数具有中学学历。研究显示腰痛与年龄和体重指数的增加有统计学意义的关系,而吸烟习惯对腰痛的发生没有影响。结论。根据年龄、性别和体重控制更好地安排工作,将减少腰痛的风险。
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引用次数: 1
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Medicinski pregled
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