Pub Date : 2022-09-27DOI: 10.13171/mjc02209271644amr
Samah Ali, B. Alharbi, A. Mohamed
: Chitosan (CS) biosorbent and polyurethane foam (PUF) synthetic sorbent have been utilized to eliminate terbinafine hydrochloride (TRB HCl) antifungal drug in its pure and pharmaceutical forms from both contaminated aqueous and biological media using a batch process. The experimental conditions for efficient removal of TRB HCl for both CS and PUF were optimized depending on various experimental parameters such as the pH of the solution, contact periods, initial TRB HCl concentration, and sorbents dosage in the solution.SEM, FT-IR, and XRD characterizations were carried out to study the adsorption of a drug by both sorbents. The optimum conditions for removing TRB HCl by CS and PUF were achieved at a pH of 8.5 and a contact time of 60 min at 250 rpm, using 0.4 g for both sorbents. The measured spectrophotometric absorbance at λmax of TRB HCl was 242 nm. In addition, the zero-point charge (pHpzc) was determined for the studied sorbents. The pHpzc of the surface of sorbents has shown that electrostatic attraction is one of the mechanisms in TRB HCl sorption. The adsorption process was modeled using the pseudo-first-order, pseudo-second-order, Elovich, and intraparticle diffusion kinetic models. The results indicated that the adsorption of TRB HCl on CS and PUF does follow a pseudo-first-order type of reaction kinetics. The adsorption process was modeled using Langmuir and Freundlich isotherms. The adsorption data found that the Freundlich isotherm model was more suitable for the PUF sorbent, while the Langmuir isotherm model better fit the CS biosorbent.Evaluation of the experimental data using the Langmuir equation revealed that the maximum adsorption capacities of PUF and CS were 2.807 and 1.2297 mg. g-1, respectively. The solution was also used to estimate TRB HCl in its pharmaceutical form, and the assessed recoveries were 97.25 and 98.437% for CS and PUF, respectively. The proposed procedure was validated for other complex mediums by removing TRB HCl from spiked human blood plasma. In-silico aquatic toxicity forecast of TRB HCl was also carried out.
{"title":"Elimination of Terbinafine Hydrochloride Antifungal Drug Traces from Water, Pharmaceutical Formulations and Blood Plasma using Low-Cost Bio and Synthetic Sorbents","authors":"Samah Ali, B. Alharbi, A. Mohamed","doi":"10.13171/mjc02209271644amr","DOIUrl":"https://doi.org/10.13171/mjc02209271644amr","url":null,"abstract":": Chitosan (CS) biosorbent and polyurethane foam (PUF) synthetic sorbent have been utilized to eliminate terbinafine hydrochloride (TRB HCl) antifungal drug in its pure and pharmaceutical forms from both contaminated aqueous and biological media using a batch process. The experimental conditions for efficient removal of TRB HCl for both CS and PUF were optimized depending on various experimental parameters such as the pH of the solution, contact periods, initial TRB HCl concentration, and sorbents dosage in the solution.SEM, FT-IR, and XRD characterizations were carried out to study the adsorption of a drug by both sorbents. The optimum conditions for removing TRB HCl by CS and PUF were achieved at a pH of 8.5 and a contact time of 60 min at 250 rpm, using 0.4 g for both sorbents. The measured spectrophotometric absorbance at λmax of TRB HCl was 242 nm. In addition, the zero-point charge (pHpzc) was determined for the studied sorbents. The pHpzc of the surface of sorbents has shown that electrostatic attraction is one of the mechanisms in TRB HCl sorption. The adsorption process was modeled using the pseudo-first-order, pseudo-second-order, Elovich, and intraparticle diffusion kinetic models. The results indicated that the adsorption of TRB HCl on CS and PUF does follow a pseudo-first-order type of reaction kinetics. The adsorption process was modeled using Langmuir and Freundlich isotherms. The adsorption data found that the Freundlich isotherm model was more suitable for the PUF sorbent, while the Langmuir isotherm model better fit the CS biosorbent.Evaluation of the experimental data using the Langmuir equation revealed that the maximum adsorption capacities of PUF and CS were 2.807 and 1.2297 mg. g-1, respectively. The solution was also used to estimate TRB HCl in its pharmaceutical form, and the assessed recoveries were 97.25 and 98.437% for CS and PUF, respectively. The proposed procedure was validated for other complex mediums by removing TRB HCl from spiked human blood plasma. In-silico aquatic toxicity forecast of TRB HCl was also carried out.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83854476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-26DOI: 10.13171/mjc02209261446csuk
Oliver Kraft, G. Mittag, Sophie Hoenke, Niels V. Heise, A. Al‐Harrasi, R. Csuk
Gewald 3-component reactions (G-3CR), i.e., reactions of a carbonyl compound with an activated nitrile in the presence of a secondary amine and sulfur, lead straightforwardly to anellated 2-aminothiophenes. Interestingly, their application to steroidal hydrocarbons has been limited to a single example. We could show in this work that Gewald 3-component reactions can be performed successfully for molecules holding a cholesterol or sitostanol skeleton, such as 5a-cholestan3-one (8) and 5a-sitostan-3-one (11), thus leading in good yields to the corresponding anellated steroidal 2-amino-thiophenes 12-15. Gewald reaction proved to be an excellent method to access heterocyclic steroids.
{"title":"Synthesis and characterization of steroidal, anellated aminothiophenes by Gewald reaction","authors":"Oliver Kraft, G. Mittag, Sophie Hoenke, Niels V. Heise, A. Al‐Harrasi, R. Csuk","doi":"10.13171/mjc02209261446csuk","DOIUrl":"https://doi.org/10.13171/mjc02209261446csuk","url":null,"abstract":"Gewald 3-component reactions (G-3CR), i.e., reactions of a carbonyl compound with an activated nitrile in the presence of a secondary amine and sulfur, lead straightforwardly to anellated 2-aminothiophenes. Interestingly, their application to steroidal hydrocarbons has been limited to a single example. We could show in this work that Gewald 3-component reactions can be performed successfully for molecules holding a cholesterol or sitostanol skeleton, such as 5a-cholestan3-one (8) and 5a-sitostan-3-one (11), thus leading in good yields to the corresponding anellated steroidal 2-amino-thiophenes 12-15. Gewald reaction proved to be an excellent method to access heterocyclic steroids.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74450488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The metal corrosion threat in the metallurgical industry is becoming increasingly important. So in this work, the inhibition properties of 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-oxo-3-(pyridin-3-yl) propanenitrile for copper corrosion in 1 M nitric acid medium were evaluated by mass loss technique, density functional theory (DFT) and quantitative structure-property relationship (QSPR) model. The results show that this compound was excellent anticorrosive properties with a maximum inhibition efficiency of 89.39 % for a concentration of 0.2 mM at 323 K. The inhibition efficiency increases with increasing temperature and inhibitor concentration. Adsorption isotherms reported that the molecule adsorbs on copper surface according to Langmuir isotherm. Thermodynamic adsorption and activation parameters were determined and analyzed. They revealed spontaneous adsorption and a strong interaction between the molecule and copper surface. DFT calculations at the B3LYP level with 6-31G(d,p) and 6-311G(d,p) basis set permitted to explain the electronic exchanges between molecule and copper, thus justifying the experimentally obtained inhibition efficiency values. A local reactivity study of molecules indicated that N (29) and C (7) atoms are the likely sites for nucleophilic and electrophilic attacks, respectively. In addition, QSPR model was used to correlate experimental inhibition efficiency with the descriptor parameters of the studied molecule, and it is found that the calculated inhibition efficiencies are close to experimental inhibition efficiencies. Finally, this study showed a good correlation between theoretical and experimental data.
{"title":"Copper corrosion inhibition in nitric acid solution by 2-(1,3-dihydrobenzimidazol-2-ylidene) -3-oxo-3-(pyridin-3-yl) propanenitrile: Gravimetric, Quantum chemical and QSPR studies","authors":"Tigori Mougo André, Aboudramane Koné, Koua N’zebo René, Mamadou Yeo, P. Niamien","doi":"10.13171/mjc02209131649tigori","DOIUrl":"https://doi.org/10.13171/mjc02209131649tigori","url":null,"abstract":"The metal corrosion threat in the metallurgical industry is becoming increasingly important. So in this work, the inhibition properties of 2-(1,3-dihydrobenzimidazol-2-ylidene)-3-oxo-3-(pyridin-3-yl) propanenitrile for copper corrosion in 1 M nitric acid medium were evaluated by mass loss technique, density functional theory (DFT) and quantitative structure-property relationship (QSPR) model. The results show that this compound was excellent anticorrosive properties with a maximum inhibition efficiency of 89.39 % for a concentration of 0.2 mM at 323 K. The inhibition efficiency increases with increasing temperature and inhibitor concentration. Adsorption isotherms reported that the molecule adsorbs on copper surface according to Langmuir isotherm. Thermodynamic adsorption and activation parameters were determined and analyzed. They revealed spontaneous adsorption and a strong interaction between the molecule and copper surface. DFT calculations at the B3LYP level with 6-31G(d,p) and 6-311G(d,p) basis set permitted to explain the electronic exchanges between molecule and copper, thus justifying the experimentally obtained inhibition efficiency values. A local reactivity study of molecules indicated that N (29) and C (7) atoms are the likely sites for nucleophilic and electrophilic attacks, respectively. In addition, QSPR model was used to correlate experimental inhibition efficiency with the descriptor parameters of the studied molecule, and it is found that the calculated inhibition efficiencies are close to experimental inhibition efficiencies. Finally, this study showed a good correlation between theoretical and experimental data.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87978524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-20DOI: 10.13171/mjc02208201639syarif
Nirwan Syarif M.Si
An electrode of non-precious metal has the potency to be utilized as a working electrode for voltammetry measurements of Cr3+ and Cr6+. The analytical performance of the electrode in determining specific metal species qualitatively and quantitatively was studied. The detection data were recorded and analyzed using cyclic voltammetry (CV) and linear sweep voltammetry (LSV), whereas scanning electron microscope (SEM) and X-ray diffraction (XRD) spectroscopy were used to determine the surface morphology and the presence of crystalline in the electrode. Electroanalytical performance was determined by linear sweep voltammetry. The results show that the reduction of Cr6+ to Cr3+ appeared at +0.84 V (vs Ag/AgCl) and the reduction of Cr3+ to Cr2+ at +0.74 V (vs Ag/Ag). The optimum conditions for measuring Cr3+ were found at pH 6, deposition time of 30 seconds, and a scan rate of 160 mVs-1. The optimum pH for measuring Cr6+ is 4, deposition time of 60 seconds, and a scan rate of 140 mVs-1. The regression curve for the Cr3+ is linear in concentration 1 – 10 gL-1 with a correlation coefficient of 0.9883 and a detection limit of 2.08 gL-1. While the Cr6+ is linear in the range of 1 – 10 gL-1 with a correlation coefficient of 0.99 and a detection limit of 2.18 gL-1. There is a slight difference in the individual measurement current and the mixture of Cr3+ and Cr6+ but with a good agreement for the oxidation-reduction potential. The measurement data analysis shows the feasibility of the electrode and the measurement system developed.
{"title":"Microdetection of Chromium Mixed–Valences using CuNi/Ti Electrode and Linear Sweep Voltammetry","authors":"Nirwan Syarif M.Si","doi":"10.13171/mjc02208201639syarif","DOIUrl":"https://doi.org/10.13171/mjc02208201639syarif","url":null,"abstract":"An electrode of non-precious metal has the potency to be utilized as a working electrode for voltammetry measurements of Cr3+ and Cr6+. The analytical performance of the electrode in determining specific metal species qualitatively and quantitatively was studied. The detection data were recorded and analyzed using cyclic voltammetry (CV) and linear sweep voltammetry (LSV), whereas scanning electron microscope (SEM) and X-ray diffraction (XRD) spectroscopy were used to determine the surface morphology and the presence of crystalline in the electrode. Electroanalytical performance was determined by linear sweep voltammetry. The results show that the reduction of Cr6+ to Cr3+ appeared at +0.84 V (vs Ag/AgCl) and the reduction of Cr3+ to Cr2+ at +0.74 V (vs Ag/Ag). The optimum conditions for measuring Cr3+ were found at pH 6, deposition time of 30 seconds, and a scan rate of 160 mVs-1. The optimum pH for measuring Cr6+ is 4, deposition time of 60 seconds, and a scan rate of 140 mVs-1. The regression curve for the Cr3+ is linear in concentration 1 – 10 gL-1 with a correlation coefficient of 0.9883 and a detection limit of 2.08 gL-1. While the Cr6+ is linear in the range of 1 – 10 gL-1 with a correlation coefficient of 0.99 and a detection limit of 2.18 gL-1. There is a slight difference in the individual measurement current and the mixture of Cr3+ and Cr6+ but with a good agreement for the oxidation-reduction potential. The measurement data analysis shows the feasibility of the electrode and the measurement system developed.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85689184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-06DOI: 10.13171/mjc02208061631ijoma
I. Ijoma, V. Ajiwe
Sickle cell disease (SCD) is a molecular disease caused by substituting glutamic acid with valine at the β-6 position of the hemoglobin, leading to the polymerization of erythrocytes that contain the hemoglobin afterward leads to severe clinical consequences. Polymerization of sickle hemoglobin occurs only in the deoxygenated form i.e only sickle deoxyhemoglobin (DeOxyHbS) polymerizes. SCD is predominant in children living in Africa, especially in West Africa. Therefore, molecular docking and molecular dynamic simulation studies were carried out on methyl ferulate isolated from Ficus thonningii leaves, a known antisickling plant used in Eastern Nigeria to manage SCD. The Harborne procedure was used for extraction, whereas the combination of column chromatography and flash chromatography was used for the isolation and purification of active principles of the leaves extract. The structure of methyl ferulate was determined based on nuclear magnetic resonance (NMR) analysis. A binding affinity of -5.8 kcal/mol indicated that methyl ferulate binds to DeOxyHbS and could interfere with the processes that trigger sickle hemoglobin polymerization in vitro. The observed variations in perturbation of both DeOxyHbS and FTH3-DeOxyHbS complex root mean square deviation (RMSD), the radius of gyration (Rgyr), solvent accessible surface area (SASA), potential energy (PE), and Van der Waal’s (VDW) interactions were obtained from the molecular dynamic simulation studies of the binding site amino acid residue performed at 500 ps and suggest that in silico methyl ferulate binds with amino acid residues reported being involved in sickle hemoglobin polymerization and thus may possess antisickling potentials in vitro.
镰状细胞病(SCD)是一种由血红蛋白β-6位置的谷氨酸被缬氨酸取代，导致含有血红蛋白的红细胞聚合而引起的分子疾病，其临床后果十分严重。镰状血红蛋白的聚合只发生在脱氧形式，即只有镰状脱氧血红蛋白(DeOxyHbS)聚合。SCD主要发生在非洲，特别是西非的儿童中。因此，对尼日利亚东部用于防治SCD的抗镰状病植物Ficus thonningii叶片中分离的阿魏酸甲酯进行了分子对接和分子动力学模拟研究。采用Harborne法提取，采用柱层析和闪蒸层析相结合的方法对叶提取物的有效成分进行分离纯化。采用核磁共振(NMR)方法测定了阿魏酸甲酯的结构。-5.8 kcal/mol的结合亲和力表明，阿威酸甲酯与脱氧血红蛋白结合，并可能干扰体外触发镰状血红蛋白聚合的过程。观察到DeOxyHbS和FTH3-DeOxyHbS复合物的扰动变化:均方根偏差(RMSD)、旋转半径(Rgyr)、溶剂可及表面积(SASA)、势能(PE)、和Van der Waal 's (VDW)相互作用是通过在500 ps下进行的结合位点氨基酸残基的分子动力学模拟研究获得的，并表明在硅中，阿魏酸甲酯与报道参与镰状血红蛋白聚合的氨基酸残基结合，因此可能具有体外抗镰状血红蛋白的潜力。
{"title":"Methyl Ferulate Induced Conformational Changes of DeOxyHbS: Implication on Sickle Erythrocyte Polymerization","authors":"I. Ijoma, V. Ajiwe","doi":"10.13171/mjc02208061631ijoma","DOIUrl":"https://doi.org/10.13171/mjc02208061631ijoma","url":null,"abstract":"Sickle cell disease (SCD) is a molecular disease caused by substituting glutamic acid with valine at the β-6 position of the hemoglobin, leading to the polymerization of erythrocytes that contain the hemoglobin afterward leads to severe clinical consequences. Polymerization of sickle hemoglobin occurs only in the deoxygenated form i.e only sickle deoxyhemoglobin (DeOxyHbS) polymerizes. SCD is predominant in children living in Africa, especially in West Africa. Therefore, molecular docking and molecular dynamic simulation studies were carried out on methyl ferulate isolated from Ficus thonningii leaves, a known antisickling plant used in Eastern Nigeria to manage SCD. The Harborne procedure was used for extraction, whereas the combination of column chromatography and flash chromatography was used for the isolation and purification of active principles of the leaves extract. The structure of methyl ferulate was determined based on nuclear magnetic resonance (NMR) analysis. A binding affinity of -5.8 kcal/mol indicated that methyl ferulate binds to DeOxyHbS and could interfere with the processes that trigger sickle hemoglobin polymerization in vitro. The observed variations in perturbation of both DeOxyHbS and FTH3-DeOxyHbS complex root mean square deviation (RMSD), the radius of gyration (Rgyr), solvent accessible surface area (SASA), potential energy (PE), and Van der Waal’s (VDW) interactions were obtained from the molecular dynamic simulation studies of the binding site amino acid residue performed at 500 ps and suggest that in silico methyl ferulate binds with amino acid residues reported being involved in sickle hemoglobin polymerization and thus may possess antisickling potentials in vitro.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75044792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-18DOI: 10.13171/mjc02112181597huremovic
M. Huremović, Majda Srabovic, M. Salihović, E. Pehlić
Fexofenadine hydrochloride (FFN), (±)-4-[1-hydroxy-4[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl] α,α-dimethylbenzeneacetic acid hydrochloride, is a second-generation antihistamine that is used to treat allergies. The drug is highly hydrophobic and slightly soluble in water. Cyclodextrins are widely used to improve the physicochemical and pharmaceutical properties such as solubility, stability, and bioavailability of poorly soluble drug molecules.Cyclodextrins can molecularly encapsulate various drugs into their hydrophobic cavity without forming any covalent bonds. Cyclodextrin (CDs), especially ß-Cyclodextrin (ß-CD), are widely used in the pharmaceutical field due to its ability to stabilize drug molecules and taste masking purposes. The phase solubility study was performed according to the method of Higuchi and Connors by adding the fexofenadine hydrochloride in excess to different concentrations of cyclodextrin solutions. Phase solubility study records show that the stability constant and complex stoichiometry of FFN-CD complexes increases linearly with CD concentration. Also, an increase in the concentration of β-cyclodextrin leads to an increase in the aqueous solubility of FFN. Complexes were analyzed by UV-VIS spectroscopy using the calibration curve of FFN. Also, UV-VIS spectra indicate a bathochromic shift which proves that complex formation has occurred.Solid inclusion complexes of fexofenadine/β-cyclodextrin and its derivatives were prepared at the molar ratios of 1:1 by the physical mixing method. Characterization of the complexes was performed by using infrared spectroscopy.
{"title":"Inclusion Complex of Fexofenadine Hydrochloride with Cyclodextrins","authors":"M. Huremović, Majda Srabovic, M. Salihović, E. Pehlić","doi":"10.13171/mjc02112181597huremovic","DOIUrl":"https://doi.org/10.13171/mjc02112181597huremovic","url":null,"abstract":"Fexofenadine hydrochloride (FFN), (±)-4-[1-hydroxy-4[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl] α,α-dimethylbenzeneacetic acid hydrochloride, is a second-generation antihistamine that is used to treat allergies. The drug is highly hydrophobic and slightly soluble in water. Cyclodextrins are widely used to improve the physicochemical and pharmaceutical properties such as solubility, stability, and bioavailability of poorly soluble drug molecules.Cyclodextrins can molecularly encapsulate various drugs into their hydrophobic cavity without forming any covalent bonds. Cyclodextrin (CDs), especially ß-Cyclodextrin (ß-CD), are widely used in the pharmaceutical field due to its ability to stabilize drug molecules and taste masking purposes. The phase solubility study was performed according to the method of Higuchi and Connors by adding the fexofenadine hydrochloride in excess to different concentrations of cyclodextrin solutions. Phase solubility study records show that the stability constant and complex stoichiometry of FFN-CD complexes increases linearly with CD concentration. Also, an increase in the concentration of β-cyclodextrin leads to an increase in the aqueous solubility of FFN. Complexes were analyzed by UV-VIS spectroscopy using the calibration curve of FFN. Also, UV-VIS spectra indicate a bathochromic shift which proves that complex formation has occurred.Solid inclusion complexes of fexofenadine/β-cyclodextrin and its derivatives were prepared at the molar ratios of 1:1 by the physical mixing method. Characterization of the complexes was performed by using infrared spectroscopy. ","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82309414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-13DOI: 10.13171/mjc02112131596ollo
Kambiré Ollo, K. Y. Urbain, Kouyaté Amadou, S. S. Placide, Kouadio Kouakou Etienne, Kimou Kouakou Jocelin, Koné Souleymane
In the present study, adsorption experiments were carried out to investigate the removal of rhodamine B from an aqueous solution using chemically activated carbon from corn cobs, a cheaper adsorbent. The characteristics of carbon were determined using X-ray diffraction, SEM, iodine number, pHpzc, and the Boehm titration method. The results show that the prepared activated carbon is amorphous, microporous, and generally acidic on the surface. The kinetic study of the adsorption of rhodamine B on this carbon was carried out, and the rate of sorption was found to conform to pseudo-second-order kinetics with 80 min as equilibrium time. The equilibrium adsorption revealed that the experimental data fitted better to the Langmuir isotherm model for removing rhodamine B. The interaction rhodamine B-activated carbon is mainly chemisorption type. The optimal conditions of rhodamine B removal onto the carbon of this study are mass of carbon = 0.3 g and pH = 3.15. The maximum monolayer adsorption capacity for rhodamine B removal was found to be 5.92 mg.g-1. This study has shown that the prepared activated carbon makes it possible to effectively clean up wastewater contaminated by rhodamine B with a removal efficiency of up to 99.60% for 300 mg of AC in 25 mL of the rhodamine B solution (5 mg.L-1).
{"title":"Removal of rhodamine B from aqueous solution by adsorption on corn cobs activated carbon","authors":"Kambiré Ollo, K. Y. Urbain, Kouyaté Amadou, S. S. Placide, Kouadio Kouakou Etienne, Kimou Kouakou Jocelin, Koné Souleymane","doi":"10.13171/mjc02112131596ollo","DOIUrl":"https://doi.org/10.13171/mjc02112131596ollo","url":null,"abstract":"In the present study, adsorption experiments were carried out to investigate the removal of rhodamine B from an aqueous solution using chemically activated carbon from corn cobs, a cheaper adsorbent. The characteristics of carbon were determined using X-ray diffraction, SEM, iodine number, pHpzc, and the Boehm titration method. The results show that the prepared activated carbon is amorphous, microporous, and generally acidic on the surface. The kinetic study of the adsorption of rhodamine B on this carbon was carried out, and the rate of sorption was found to conform to pseudo-second-order kinetics with 80 min as equilibrium time. The equilibrium adsorption revealed that the experimental data fitted better to the Langmuir isotherm model for removing rhodamine B. The interaction rhodamine B-activated carbon is mainly chemisorption type. The optimal conditions of rhodamine B removal onto the carbon of this study are mass of carbon = 0.3 g and pH = 3.15. The maximum monolayer adsorption capacity for rhodamine B removal was found to be 5.92 mg.g-1. This study has shown that the prepared activated carbon makes it possible to effectively clean up wastewater contaminated by rhodamine B with a removal efficiency of up to 99.60% for 300 mg of AC in 25 mL of the rhodamine B solution (5 mg.L-1).","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83447184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-28DOI: 10.13171/mjc02110281589salhi
S. Cherrouf, Y. Salhi, Amina El Echhab, Hassan El Grini, Jihane Tellal, M. Cherkaoui, B. Lakhrissi
The tin coating was elaborated electrolytically on an ordinary steel substrate in SnSO4 based electrolyte in acid medium with additive (bis-glycobenzimidazolone) at ambient temperature. The pH is maintained at 1.2±0.2 Bis-glycobenzimidazolone influence on the electrochemical properties of the tin coating was investigated using stationary polarization, chronopotentiometry, and cyclic voltammetry techniques. These studies show an apparent decrease in cathodic peak current and a drop in potential. The deposition rate also decreases as the concentration of the additive increases. SEM (Scanning Electron Microscopy) observation and XRD (X-ray Diffraction) analysis showed that the coating consists of good surface quality of the deposit elaborated by the addition of an optimal concentration of bis-glycobenzimidazolone (10-3M) in the electrolyte, which constitutes the continuation of a preliminary study.
{"title":"Electrochemical study and characterization of tin coatings with and without glucose-based additive","authors":"S. Cherrouf, Y. Salhi, Amina El Echhab, Hassan El Grini, Jihane Tellal, M. Cherkaoui, B. Lakhrissi","doi":"10.13171/mjc02110281589salhi","DOIUrl":"https://doi.org/10.13171/mjc02110281589salhi","url":null,"abstract":"The tin coating was elaborated electrolytically on an ordinary steel substrate in SnSO4 based electrolyte in acid medium with additive (bis-glycobenzimidazolone) at ambient temperature. The pH is maintained at 1.2±0.2 Bis-glycobenzimidazolone influence on the electrochemical properties of the tin coating was investigated using stationary polarization, chronopotentiometry, and cyclic voltammetry techniques. These studies show an apparent decrease in cathodic peak current and a drop in potential. The deposition rate also decreases as the concentration of the additive increases. SEM (Scanning Electron Microscopy) observation and XRD (X-ray Diffraction) analysis showed that the coating consists of good surface quality of the deposit elaborated by the addition of an optimal concentration of bis-glycobenzimidazolone (10-3M) in the electrolyte, which constitutes the continuation of a preliminary study.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81305117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-16DOI: 10.13171/mjc02110161595cesuk
Niels V. Heise, Sophie Hoenke, A. Al‐Harrasi, H. Deigner, R. Csuk
3-O-Acetyl-glycyrrhetinic amides were prepared, and sulforhodamine B assays investigated their cytotoxicity. Their cytotoxicity strongly depended on the substitution pattern of the respective compounds. Thereby, an ethylenediamine-derived compound 2 performed the best, acting mainly by apoptosis. As far as heterocyclic amides are concerned, ring enlargement and the replacement of the distal nitrogen invariably led to a more or less complete loss of cytotoxic activity. Thus, the presence of a carbonyl function (C-30) seems necessary for providing significant cytotoxicity.
制备了3- o -乙酰-甘草次胺，并对其进行了细胞毒性测定。它们的细胞毒性强烈依赖于各自化合物的取代模式。因此，乙二胺衍生的化合物2表现最好，主要通过细胞凋亡起作用。就杂环酰胺而言，环扩大和远端氮的替换总是导致细胞毒性活性或多或少完全丧失。因此，羰基功能(C-30)的存在对于提供显著的细胞毒性似乎是必要的。
{"title":"Glycyrrhetinic amides and their cytotoxicity","authors":"Niels V. Heise, Sophie Hoenke, A. Al‐Harrasi, H. Deigner, R. Csuk","doi":"10.13171/mjc02110161595cesuk","DOIUrl":"https://doi.org/10.13171/mjc02110161595cesuk","url":null,"abstract":"3-O-Acetyl-glycyrrhetinic amides were prepared, and sulforhodamine B assays investigated their cytotoxicity. Their cytotoxicity strongly depended on the substitution pattern of the respective compounds. Thereby, an ethylenediamine-derived compound 2 performed the best, acting mainly by apoptosis. As far as heterocyclic amides are concerned, ring enlargement and the replacement of the distal nitrogen invariably led to a more or less complete loss of cytotoxic activity. Thus, the presence of a carbonyl function (C-30) seems necessary for providing significant cytotoxicity.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76962312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This work deals with the electrochemical behavior and detection of an iodine contrast product using microelectrode. For this, cyclic voltammetry and differential pulse were used for behavior study and detection, respectively. In this work, a boron-doped diamond (BDD) microelectrode was used. Cyclic voltammetry showed that the oxidation peak of iohexol (IHX) appeared at a potential of 1.655 V/ESM in H 2 SO 4 medium (0.1 M). The electrooxidation process of IHX is irreversible, controlled by diffusion combined par adsorption, and can undergo direct and/or indirect oxidation. In addition, using the differential pulse voltammetry technique, the peak oxidation current shows a linear relationship with the IHX concentration between 4 µmol/L and 74.35 µ mol/L. The calculated limit of detection (LOD) and limit of quantification (LOQ) are 1.953 µmol/L and 6.511 µmol/L, respectively. Recovery rates ranging from 95% to 99% in the presence of interfering compounds (inorganic compounds with concentrations 300 times higher than that of IHX). In addition, the DDB successfully recovered the concentration (20 µmol/L) of IHX dissolved with paracetamol concentrations ranging from 31 µmol/L to 149.66 µmol/L. These results suggest that the BDD can be used as a practical sensor to detect and quantify trace amounts of IHX.
{"title":"Cyclic and differential pulse voltammetry investigations of an iodine contrast product using microelectrode of BDD","authors":"Koffi Konan Konan, Foffié Thiery Auguste Appia, Kouadio Kouakou Etienne, Kimou Kouakou Jocelin, Koné Souleymane, Ouattara Lassiné","doi":"10.13171/MJC02109301594LASSINé","DOIUrl":"https://doi.org/10.13171/MJC02109301594LASSINé","url":null,"abstract":"This work deals with the electrochemical behavior and detection of an iodine contrast product using microelectrode. For this, cyclic voltammetry and differential pulse were used for behavior study and detection, respectively. In this work, a boron-doped diamond (BDD) microelectrode was used. Cyclic voltammetry showed that the oxidation peak of iohexol (IHX) appeared at a potential of 1.655 V/ESM in H 2 SO 4 medium (0.1 M). The electrooxidation process of IHX is irreversible, controlled by diffusion combined par adsorption, and can undergo direct and/or indirect oxidation. In addition, using the differential pulse voltammetry technique, the peak oxidation current shows a linear relationship with the IHX concentration between 4 µmol/L and 74.35 µ mol/L. The calculated limit of detection (LOD) and limit of quantification (LOQ) are 1.953 µmol/L and 6.511 µmol/L, respectively. Recovery rates ranging from 95% to 99% in the presence of interfering compounds (inorganic compounds with concentrations 300 times higher than that of IHX). In addition, the DDB successfully recovered the concentration (20 µmol/L) of IHX dissolved with paracetamol concentrations ranging from 31 µmol/L to 149.66 µmol/L. These results suggest that the BDD can be used as a practical sensor to detect and quantify trace amounts of IHX.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"1 1","pages":"244-254"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91362587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：