Mediterranean Journal of Chemistry最新文献

The roots of the Dolomiaea costus (SCO) plant were used as a new, low-cost, eco-friendly, and efficient biosorbent for the removal of Amprolium hydrochloride (AMP) antibacterial veterinary drug residues from aqueous media. The effect of different parameters, such as the initial concentration of AMP, pH, contact time, adsorbent dosage, and temperature, was investigated. The results showed that the best removal of the AMP drug by SCO was reached at a pH of 3.6 at a contact time of 80 min by a sorbent dosage of 0.04 g at a temperature of 45°C. Adsorption isotherm studies indicated that the AMP removal correlates more with the Freundlich isotherm with R²= 0.991. The maximum adsorption capacity has reached 83% based on the adsorption isotherm studies. The kinetics studies showed that adsorption follows a pseudo-second-order model with R² = 0.999. The thermodynamic studies showed that the adsorption process of AMP on SCO is spontaneous in nature and exothermic, with an increase in randomness during the adsorption.

A novel title complex [(µ-chlorido)(µ-methoxido- O)bis-[(2,2´-bipy-k²N,N´)(chlorido) Copper(II)]] crystallizes in the monoclinic space group C2/c with unit cell parameters, a = 14.4775(2)Å, b =11.118(2)Å, c = 13.1617(2)Å, α= 90º, β=92º and γ= 90º,have two very similar distorted square-pyramidal [Cu₂(2,2´-bpy)₂Cl₃(OCH₆)] (1) chromophores adopting 4+1 geometrical arrangement. The u-OCH₆ and u-Cl bridges occupy a crystallographic inversion center. The novelty of this complex stems from the occupancy site (s.o.f = 0.5) of the unusual six H-atoms of the methoxy bridging group. The bridging Cl-atom occupied the axial site of the distorted square-pyramidal, which is significantly longer than the rest of the other four-basal sites. Due to axial site occupation by Cl-bridging, the two bpy-ligands lie almost perpendicular to each other. The packing structure of the title complex reveals that this structure contains inter-and intra-molecular H-bonds and ꙥ-ꙥ- intermolecular interactions.

Based on prior research findings with pentacyclic triterpenoids, it was hypothesized that (un)-substituted benzylamides would exhibit enhanced cytotoxic activity compared to parent abietic acid. Conversely, none of these compounds was cytotoxic, but (homo)-piperazinyl amides demonstrated significant cytotoxic activity across multiple cell lines, even at concentrations as low single-digit micromolar levels. Additional staining experiments revealed that the most potent compound (with an EC₅₀ value of 2.8 mM for HT29 colon carcinoma cells) primarily induced apoptosis rather than necrosis.  

A novel mixed molecular Cu (II) and Co (II) complexes [Cu L₂]_0.82 and [CoL₂]_0.18 (1) where HL = (4-salicylaldaimine antipyrine) derived from 4-aminoantipyrine and 2-hydroxybenzaldehyde, was isolated as a green solid and characterized by Fourier Transform Infrared Spectroscopy (FTIR), Ultra-Violet Visible spectroscopy (UV-Vis) and Single-crystal x-ray diffraction. Compound 1 is a solid-state solution that contains a statistical mixture of two different molecular complexes: 82% of a 17-electron Cu (II) complex and 18% of a 15-electron Co (II) complex. By looking at the structure, it seems that the two metal ions occupy the same metal site, which is not true; at least a small distance between them exists, verified using the Density functional theory (DFT). A divalent metal cation binds four coordination sites in each molecular complex from two corresponding bidentate Schiff base ligands. Each metal atom is coordinated with two nitrogen and two oxygen atoms of the Schiff base ligand in a geometry much closer to pseudo-tetrahedral than planar. DFT calculations were used to validate the trends observed in bond lengths and angles in this structure. By using the DFT methods, it is seen that there are no significant differences in the experimental values obtained by single-crystal X-ray diffraction. It should be noted that the experimental results belong to the solid phase, while the theoretical calculations belong to the gas phase.