Pub Date : 2023-03-23DOI: 10.13171/mjc02303231693jean_emmanuel
Jean Emmanuel Mbosso Teinkela, Zouleha Ali, C. Ngoule, Bienvenu Tsakem, J. C. Assob Nguedia, Francois Meva Eya’ane, X. Siwe Noundou
This study aimed to determine the phytochemical profile, acute toxicity, and antioxidant activity of leaves, stem bark, and roots of methanolic extracts of Annickia affinis. Phytochemical screening was done to highlight the secondary metabolites present in the plant. The in vitro antioxidant activity was carried out using the DPPH free radical trapping method based on our extracts' reduction of the DPPH radical. This was evaluated by measuring the absorbance of all concentrations of extracts tested at 517 nm. Whereas the total phenol content was quantified using the reagent of “Folin-Ciocalteu,” measurable using a spectrophotometer at 765 nm. The in vivo acute toxicity study was conducted according to guideline 423 of the Organisation for Economic Co-operation and Development (OECD) protocol at a fixed dose in Wistar rats. Phytochemical screening of the different extracts revealed the presence of alkaloids, saponins, triterpenoids, anthraquinones, anthocyanins, and coumarins. The extracts of the leaves, stem bark, and roots showed good DPPH radical scavenging activity with IC50 values of 0.34 µg/mL, 0.37 µg/mL, and 0.22 µg/mL, respectively; these values were very close to that recorded for the standard, Butyl hydroxytoluène (BHT) (0.14 µg/mL). The total phenolic contents were 122.11 µgEqGA/g for the leaves, 47.11 µgEqGA/g for the stem bark, and 109.95 µgEqGA/g for the roots. An oral administration of all extracts did not cause an abnormal variation of the physiological parameters in female Wistar laboratory rats at doses of 2000 and 5000 mg/kg body weight up to 14 days after administration. The methanolic extracts of the leaves, stem bark, and roots of A. affinis are thus non-toxic at a dose as high as 5000 mg/kg body weight. They all have good antioxidant activity, the best activity recorded for the roots. It would be beneficial to suggest A. affinis to local populations against pathologies linked to oxidative stress after the preclinical and clinical tests.
{"title":"Phytochemical profile, antioxidant activity, and acute toxicity of methanolic extracts of Annickia affinis (Exell) Versteegh & Sosef leaves stem bark and roots","authors":"Jean Emmanuel Mbosso Teinkela, Zouleha Ali, C. Ngoule, Bienvenu Tsakem, J. C. Assob Nguedia, Francois Meva Eya’ane, X. Siwe Noundou","doi":"10.13171/mjc02303231693jean_emmanuel","DOIUrl":"https://doi.org/10.13171/mjc02303231693jean_emmanuel","url":null,"abstract":"This study aimed to determine the phytochemical profile, acute toxicity, and antioxidant activity of leaves, stem bark, and roots of methanolic extracts of Annickia affinis. Phytochemical screening was done to highlight the secondary metabolites present in the plant. The in vitro antioxidant activity was carried out using the DPPH free radical trapping method based on our extracts' reduction of the DPPH radical. This was evaluated by measuring the absorbance of all concentrations of extracts tested at 517 nm. Whereas the total phenol content was quantified using the reagent of “Folin-Ciocalteu,” measurable using a spectrophotometer at 765 nm. The in vivo acute toxicity study was conducted according to guideline 423 of the Organisation for Economic Co-operation and Development (OECD) protocol at a fixed dose in Wistar rats. Phytochemical screening of the different extracts revealed the presence of alkaloids, saponins, triterpenoids, anthraquinones, anthocyanins, and coumarins. The extracts of the leaves, stem bark, and roots showed good DPPH radical scavenging activity with IC50 values of 0.34 µg/mL, 0.37 µg/mL, and 0.22 µg/mL, respectively; these values were very close to that recorded for the standard, Butyl hydroxytoluène (BHT) (0.14 µg/mL). The total phenolic contents were 122.11 µgEqGA/g for the leaves, 47.11 µgEqGA/g for the stem bark, and 109.95 µgEqGA/g for the roots. An oral administration of all extracts did not cause an abnormal variation of the physiological parameters in female Wistar laboratory rats at doses of 2000 and 5000 mg/kg body weight up to 14 days after administration. The methanolic extracts of the leaves, stem bark, and roots of A. affinis are thus non-toxic at a dose as high as 5000 mg/kg body weight. They all have good antioxidant activity, the best activity recorded for the roots. It would be beneficial to suggest A. affinis to local populations against pathologies linked to oxidative stress after the preclinical and clinical tests.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81958268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.13171/mjc02303211679kumar
K. Kumar, Mithun Kori, Himanshu Pandey, Satyesh Raj Anand, N. Mishra, S. Shrivastava
Here, we have synthesized the hetero-atoms containing; 3, 4, 6–Triazabicyclo [6, 3, 1] dodeca–1 (12), 2, 6, 8, 10–pentene–5–thione (TBD) macrocyclic Schiff base ligand for the application in antituberculosis (anti-TB). This TBD ligand moiety has high donor ability due to the presence of three nitrogen donor atoms, which are also the reason for the interaction between the ligand and protein molecule. The TBD Schiff base ligand is characterized by various spectroscopic techniques such as; Fourier-Transform Infrared (FT-IR), Proton Nuclear Magnetic Resonance (1HNMR), and Ultraviolet-Visible (UV-Vis) and Electron Spray Ionization (ESI) Mass spectroscopy, to understand the bond stretching, the electronic environment of protons, electronic transitions (p–p* and n–p*), and M/Z values, respectively. The computational study was carried out to calculate the molecular docking score using AutoDock Vina software against the glutamine protein enzyme (PDB ID-3ZXR). The molecular docking score was –6.3 kcal mol-1 for the TBD Schiff base ligand, whereas –4.6 kcal mol-1 is reported for the standard drug (Pyrazinamide). The product formation yield of TBD Schiff base ligand is found to be ~78 % during synthesis.
{"title":"Study of In Silico on Schiff Base Ligand Against Mycobacterium Tuberculosis","authors":"K. Kumar, Mithun Kori, Himanshu Pandey, Satyesh Raj Anand, N. Mishra, S. Shrivastava","doi":"10.13171/mjc02303211679kumar","DOIUrl":"https://doi.org/10.13171/mjc02303211679kumar","url":null,"abstract":"Here, we have synthesized the hetero-atoms containing; 3, 4, 6–Triazabicyclo [6, 3, 1] dodeca–1 (12), 2, 6, 8, 10–pentene–5–thione (TBD) macrocyclic Schiff base ligand for the application in antituberculosis (anti-TB). This TBD ligand moiety has high donor ability due to the presence of three nitrogen donor atoms, which are also the reason for the interaction between the ligand and protein molecule. The TBD Schiff base ligand is characterized by various spectroscopic techniques such as; Fourier-Transform Infrared (FT-IR), Proton Nuclear Magnetic Resonance (1HNMR), and Ultraviolet-Visible (UV-Vis) and Electron Spray Ionization (ESI) Mass spectroscopy, to understand the bond stretching, the electronic environment of protons, electronic transitions (p–p* and n–p*), and M/Z values, respectively. The computational study was carried out to calculate the molecular docking score using AutoDock Vina software against the glutamine protein enzyme (PDB ID-3ZXR). The molecular docking score was –6.3 kcal mol-1 for the TBD Schiff base ligand, whereas –4.6 kcal mol-1 is reported for the standard drug (Pyrazinamide). The product formation yield of TBD Schiff base ligand is found to be ~78 % during synthesis.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75144511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.13171/mjc02303201671singh
Shweta Singh, R. Yadava, R. Yadav, V. Surywanshi
A new bioactive isoflavone glycoside with a molecular formula C34H42O20, melting point 261°C-263°C and [M]+ 770 was isolated from the methanol soluble fraction of 90% methanolic extract of the stem of Ficus arnottiana Miq. The compound was illustrated as a new bioactive isoflavone glycoside 5,6,5ˈ-trihydroxy-8,3ˈ-dimethoxy-isoflavone 5ˈ-O-α-L-rhamnopyranosyl (1→3) O-α-L xylopyranosyl 5-O-β-D-glucopyranoside were characterized with the help of various chemical reactions, Fourier transforms infrared spectroscopy (FT-IR), Nuclear magnetic resonance spectroscopy (1HNMR), Mass spectrometry (LC-MS) and chemical degradations. Isolated compounds were also used for the antimicrobial activity of micro-organisms worked successfully tested against all strains: Escherichia coli, Bacillus cereus, and Staphylococcus aureus, while the least activity by Pseudomonas aeruginosa.
{"title":"A new biopotentially active isoflavone glycoside from the stem of Ficus arnottiana Miq.","authors":"Shweta Singh, R. Yadava, R. Yadav, V. Surywanshi","doi":"10.13171/mjc02303201671singh","DOIUrl":"https://doi.org/10.13171/mjc02303201671singh","url":null,"abstract":"A new bioactive isoflavone glycoside with a molecular formula C34H42O20, melting point 261°C-263°C and [M]+ 770 was isolated from the methanol soluble fraction of 90% methanolic extract of the stem of Ficus arnottiana Miq. The compound was illustrated as a new bioactive isoflavone glycoside 5,6,5ˈ-trihydroxy-8,3ˈ-dimethoxy-isoflavone 5ˈ-O-α-L-rhamnopyranosyl (1→3) O-α-L xylopyranosyl 5-O-β-D-glucopyranoside were characterized with the help of various chemical reactions, Fourier transforms infrared spectroscopy (FT-IR), Nuclear magnetic resonance spectroscopy (1HNMR), Mass spectrometry (LC-MS) and chemical degradations. Isolated compounds were also used for the antimicrobial activity of micro-organisms worked successfully tested against all strains: Escherichia coli, Bacillus cereus, and Staphylococcus aureus, while the least activity by Pseudomonas aeruginosa.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91275157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-18DOI: 10.13171/mjc02303171651mosaddegh
Fatemeh Ranjbar, E. Mosaddegh, A. Hassankhani, M. Torkzadeh-Mahani
The new anti-cancer and water-soluble curcumin derivatives have been synthesized solvent-freely by functionalizing the phenolic group of curcumin with various NH compounds to increase water solubility and cancerous properties. The biological applications of the new drugs have been investigated against the highly potent HepG2 carcinoma cell line. The studies showed that new curcumin derivatives could be used in low concentrations (µM/l<1) to avoid the anti-apoptotic properties against the cancerous cell. Also, the designed molecules with concentrations below 1 µM/l showed a good percentage of viability of 31.5, 45.3, and 66.7% against HepG2 cells. Furthermore, FTIR and 1H, and 13CNMR spectroscopy fully characterized the new curcumin derivatives.
{"title":"Design and synthesis of novel anti-cancer curcumin derivatives: Investigation of anti-cancer properties against HepG2 cell line","authors":"Fatemeh Ranjbar, E. Mosaddegh, A. Hassankhani, M. Torkzadeh-Mahani","doi":"10.13171/mjc02303171651mosaddegh","DOIUrl":"https://doi.org/10.13171/mjc02303171651mosaddegh","url":null,"abstract":"The new anti-cancer and water-soluble curcumin derivatives have been synthesized solvent-freely by functionalizing the phenolic group of curcumin with various NH compounds to increase water solubility and cancerous properties. The biological applications of the new drugs have been investigated against the highly potent HepG2 carcinoma cell line. The studies showed that new curcumin derivatives could be used in low concentrations (µM/l<1) to avoid the anti-apoptotic properties against the cancerous cell. Also, the designed molecules with concentrations below 1 µM/l showed a good percentage of viability of 31.5, 45.3, and 66.7% against HepG2 cells. Furthermore, FTIR and 1H, and 13CNMR spectroscopy fully characterized the new curcumin derivatives.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88933219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-12DOI: 10.13171/mjc03303021681singh
Kesari Singh, R. Yadava, R. Yadav
Commelina obliqua Vahl. This plant is a member of the Commelinaceae family, commonly referred to as the dayflower family. An entirely new bioactive compound recently discovered and identified 3, 5, 7, 3' 4′-pentahydroxy flavone-7-O-L-ribopyranosyl-3′-O-D-galactopyranoside having a melting point 320-22°C, molecular formula C26H28O16, m/z [595-H]- ESI-MS negative mode by different chemical color reactions, chemical decomposition, and spectral analysis 1HNMR, 13CNMR, Electron spray ionization mass spectrometry, Fourier transform infrared spectroscopy. An in vitro anti-inflammatory test revealed significant anti-inflammatory effects besides the degradation of egg albumin. Compound M illustrated the more percentage inhibitory action (123.1974%) of protein denaturation at 500 μg/ml, and Diclofenac sodium demonstrated less inhibitory activity (120.0627%) at the equivalent combination. As a result, Compound M inhibits protein denaturation more effectively than Diclofenac sodium at the same combination. Therefore, compound M may utilize as an anti-inflammatory source.
斜柱头。这种植物是Commelinaceae家族的一员，通常被称为天花科。最近发现并鉴定了一种全新的生物活性化合物3,5,7,3 ' 4 ' -五羟基黄酮-7- o - l-核糖吡喃基-3 ' - o - d -半乳糖吡喃苷，熔点320-22℃，分子式C26H28O16, m/z [585 - h]- ESI-MS负模式，通过不同的化学颜色反应，化学分解，光谱分析1HNMR, 13CNMR，电子喷雾电离质谱，傅里叶变换红外光谱。体外抗炎实验显示，除能降解蛋白蛋白外，还具有显著的抗炎作用。化合物M在500 μg/ml时对蛋白质变性的抑制率较高(123.1974%)，而双氯芬酸钠在相同组合下对蛋白质变性的抑制率较低(120.0627%)。因此，在相同的组合下，化合物M比双氯芬酸钠更有效地抑制蛋白质变性。因此，化合物M可作为抗炎源。
{"title":"Bioactive flavonoid from the Commelina obliqua Vahl. and its In vitro anti-inflammatory activity","authors":"Kesari Singh, R. Yadava, R. Yadav","doi":"10.13171/mjc03303021681singh","DOIUrl":"https://doi.org/10.13171/mjc03303021681singh","url":null,"abstract":"Commelina obliqua Vahl. This plant is a member of the Commelinaceae family, commonly referred to as the dayflower family. An entirely new bioactive compound recently discovered and identified 3, 5, 7, 3' 4′-pentahydroxy flavone-7-O-L-ribopyranosyl-3′-O-D-galactopyranoside having a melting point 320-22°C, molecular formula C26H28O16, m/z [595-H]- ESI-MS negative mode by different chemical color reactions, chemical decomposition, and spectral analysis 1HNMR, 13CNMR, Electron spray ionization mass spectrometry, Fourier transform infrared spectroscopy. An in vitro anti-inflammatory test revealed significant anti-inflammatory effects besides the degradation of egg albumin. Compound M illustrated the more percentage inhibitory action (123.1974%) of protein denaturation at 500 μg/ml, and Diclofenac sodium demonstrated less inhibitory activity (120.0627%) at the equivalent combination. As a result, Compound M inhibits protein denaturation more effectively than Diclofenac sodium at the same combination. Therefore, compound M may utilize as an anti-inflammatory source.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84047490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-12DOI: 10.13171/mjc02303071666souza
D. C. Santos, R. Henriques, Marcos Antonio Abreu Lopes Jr, P. J. S. Maia, Andreza Miranda Barata Silva, D. Paschoal, Andréa Luzia Ferreira Souza
This article reports the synthesis of seven Zn(II) complexes containing N-acylhydrazone ligands (L1 to L7) and the assessment of their antioxidant. Microwave assisted-synthesis of ligands with ZnCl2 in MeOH yielded tetrahedral Zn(II) complexes with a 1:2 metal: ligand ratio, characterized by HRMS, FTIR, and UV-Vis spectroscopy, thermal and electrochemical analyses, and DFT calculations. The (L3)2Zn complex exhibited the lowest thermal stability, and (L6)2Zn and (L7)2Zn were the most stable. XRD powder showed that all complexes have good crystallinity with crystalline dimensions ranging from 32 to 86 nm. Cyclic voltammetry of Zn(II) complexes indicated a reversible redox process for (L4)2Zn and an irreversible process for the remaining six complexes: (L1)2Zn to (L3)2Zn and (L5)2Zn to (L7)2Zn. Antioxidant activity of ligands and complexes was assessed by the DPPH method; the L7 ligand and corresponding (L7)2Zn complex exhibited good activity, IC50 = 65.30 μmol.l-1 and 78.70 μmol.l-1, respectively, when compared with standard ascorbic acid.
{"title":"Microwave-assisted synthesis, spectral characterization and DFT studies of Zn(II) complexes based on N-acylhydrazone ligands: stability and antioxidant activity","authors":"D. C. Santos, R. Henriques, Marcos Antonio Abreu Lopes Jr, P. J. S. Maia, Andreza Miranda Barata Silva, D. Paschoal, Andréa Luzia Ferreira Souza","doi":"10.13171/mjc02303071666souza","DOIUrl":"https://doi.org/10.13171/mjc02303071666souza","url":null,"abstract":"<p class=\"03Abstract\">This article reports the synthesis of seven Zn(II) complexes containing <em>N</em>-acylhydrazone ligands (<strong>L1 </strong>to<strong> L7</strong>) and the assessment of their antioxidant. Microwave assisted-synthesis of ligands with ZnCl<sub>2</sub> in MeOH yielded tetrahedral Zn(II) complexes with a 1:2 metal: ligand ratio, characterized by HRMS, FTIR, and UV-Vis spectroscopy, thermal and electrochemical analyses, and DFT calculations. The <strong>(L3)<sub>2</sub>Zn</strong> complex exhibited the lowest thermal stability, and <strong>(L6)<sub>2</sub>Zn</strong> and <strong>(L7)<sub>2</sub>Zn</strong> were the most stable. XRD powder showed that all complexes have good crystallinity with crystalline dimensions ranging from 32 to 86 nm. Cyclic voltammetry of Zn(II) complexes indicated a reversible redox process for <strong>(L4)<sub>2</sub>Zn</strong> and an irreversible process for the remaining six complexes: <strong>(L1)<sub>2</sub>Zn </strong>to <strong>(L3)<sub>2</sub>Zn</strong> and <strong>(L5)<sub>2</sub>Zn</strong> to <strong>(L7)<sub>2</sub>Zn</strong>. Antioxidant activity of ligands and complexes was assessed by the DPPH method; the <strong>L7 </strong>ligand and corresponding <strong>(L7)<sub>2</sub>Zn</strong> complex exhibited good activity, IC<sub>50</sub> = 65.30 μmol.l<sup>-1 </sup>and 78.70 μmol.l<sup>-1</sup>, respectively, when compared with standard ascorbic acid. <strong></strong></p>","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85331115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-16DOI: 10.13171/mjc02302161680tariq
Zain Waheed, Sadia Ghazanfar, M. Usman, Kalid Mahmood, Ajaz Hussain, Muhammad Siraj Ud din, Muhammad Tariq
The present research prepared a ternary composite g-C3N4-MoO3/rGO using the ultrasonic-assisted wet impregnation method. The prepared photocatalyst was characterized by using Fourier transform infrared spectroscopy (FT-IR), Powder X-ray diffraction (XRD), scanning electron microscopy (SEM), and EDX(Energy dispersive X-ray) techniques. The structure and morphology of pure MoO3, g-C3N4, binary composite g-C3N4-MoO3, and ternary composite g-C3N4-MoO3/rGO have been studied in their photocatalytic performance in the degradation of Rhodamine B (Rh-B) was tested and compared. The ternary composite g-C3N4-MoO3/rGO exhibited better degradation efficiency of 80% than pure and binary composite. The synergistic effect of the three components resulted in enhanced light-capturing ability, high charge separation, and low recombination rate of electron-hole pair.
{"title":"Synthesis and Characterization of Ternary Composite g-C3N4-MoO3/rGO for Photocatalytic Activity","authors":"Zain Waheed, Sadia Ghazanfar, M. Usman, Kalid Mahmood, Ajaz Hussain, Muhammad Siraj Ud din, Muhammad Tariq","doi":"10.13171/mjc02302161680tariq","DOIUrl":"https://doi.org/10.13171/mjc02302161680tariq","url":null,"abstract":"<p>The present research prepared a ternary composite g-C3N4-MoO3/rGO using the ultrasonic-assisted wet impregnation method. The prepared photocatalyst was characterized by using Fourier transform infrared spectroscopy (FT-IR), Powder X-ray diffraction (XRD), scanning electron microscopy (SEM), and EDX(Energy dispersive X-ray) techniques. The structure and morphology of pure MoO<sub>3, </sub>g-C<sub>3</sub>N<sub>4</sub>, binary composite g-C<sub>3</sub>N<sub>4</sub>-MoO<sub>3,</sub> and ternary composite g-C<sub>3</sub>N<sub>4</sub>-MoO<sub>3</sub>/rGO have been studied in their photocatalytic performance in the degradation of Rhodamine B (Rh-B) was tested and compared. The ternary composite g-C<sub>3</sub>N<sub>4</sub>-MoO<sub>3</sub>/rGO exhibited better degradation efficiency of 80% than pure and binary composite. The synergistic effect of the three components resulted in enhanced light-capturing ability, high charge separation, and low recombination rate of electron-hole pair. </p>","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90143874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-03DOI: 10.13171/mjc02302031664das-dangi
Hemlata Dangi, A. Roy, Aayushi Chanderiya, S. Kashaw, R. Das
In this study, we describe the creation of a straightforward and incredibly effective protocol for the synthesis of new 3-Substituted indole derivatives. This multicomponent reaction involved indole, acetylacetone and active aldehyde derivatives in the presence of ethanol as solvent followed by acetonitrile as a base. We go through current developments in organic synthesis methodology for multicomponent reactions that produce substituted indole derivatives with a more environmentally friendly base catalytic condition, as well as the applications that go along with them. FT-IR, 1H-NMR and MS are used to characterise the synthesized compound of indole derivatives. Antibacterial activity of synthesized compounds has also been done.
{"title":"One pot synthesis of some novel indole derivatives and their antimicrobial activity","authors":"Hemlata Dangi, A. Roy, Aayushi Chanderiya, S. Kashaw, R. Das","doi":"10.13171/mjc02302031664das-dangi","DOIUrl":"https://doi.org/10.13171/mjc02302031664das-dangi","url":null,"abstract":"In this study, we describe the creation of a straightforward and incredibly effective protocol for the synthesis of new 3-Substituted indole derivatives. This multicomponent reaction involved indole, acetylacetone and active aldehyde derivatives in the presence of ethanol as solvent followed by acetonitrile as a base. We go through current developments in organic synthesis methodology for multicomponent reactions that produce substituted indole derivatives with a more environmentally friendly base catalytic condition, as well as the applications that go along with them. FT-IR, 1H-NMR and MS are used to characterise the synthesized compound of indole derivatives. Antibacterial activity of synthesized compounds has also been done. ","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86098537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-31DOI: 10.13171/mjc02301311676singh
Ashutosh Kumar Singh, R. Yadava, Ritu Yadav, Satya Prakash Shreevastava
A new biologically active Allelochemical 3,5,7,3’,4’-pentahydroxyflavone-3-O-β-D xylopyranosyl -(1→4)- β-D-glucopyranosyl-4’-O-α-L-arabinoside (A1) whose m.p. is 340–345 0C, m.f. [M+] 728 (EIMS) was isolated from methanolic leaf extracts ofDalbergia paniculata Roxb. It was characterized by several color reactions, spectral analysis FTIR, 1H-NMR, GC-MS, and chemical degradations. The results of the antimicrobial activity of (A1) at high concentration (100µg/mL) was 20, 17, and 15 mm zone of inhibition against E. coli, B. cereus, and S. aureus aeruginosa, respectively. The data demonstrated that the antimicrobial activity of CH3 OH soluble fraction (A1 ) at all concentrations was highest against E. coli and lowest S. aureus.E. coli, B. cereus, and S. aureus aeruginosa, respectively 7.3, 2.1, and 0.02mm, MIC was defined as the minimum concentration of assayed samples that inhibited the visible growth of the tested microorganism. MIC in E. coli, B. cereus, and S. aureus aeruginosa was 7.3, 2.1, and 0.02mm, respectively.
从黄檀(Dalbergia paniculata Roxb)的甲醇叶提取物中分离到一种新的具有生物活性的化感化学物质3,5,7,3 '，4 ' -pentahydroxyflavone-3- o -β- d xylopyranosyl -(1→4)- β-D-glucopyranosyl-4 ' - o -α- l- arabinoside (A1)，其m.f. [M+] 728 (EIMS)的m.p值为340-345°c。通过多种显色反应、光谱分析、FTIR、1H-NMR、GC-MS和化学降解对其进行了表征。结果表明，(A1)在高浓度(100µg/mL)下对大肠杆菌、蜡样芽孢杆菌和铜绿金黄色葡萄球菌的抑菌活性分别为20、17和15 mm。结果表明，各浓度下CH3 OH可溶性组分(A1)对大肠杆菌的抑菌活性最高，对金黄色葡萄球菌的抑菌活性最低。E. coli、B. cereus和S. aureus aeruginosa分别为7.3、2.1和0.02mm, MIC定义为检测样品抑制被测微生物可见生长的最小浓度。大肠杆菌、蜡样芽孢杆菌和铜绿金黄色葡萄球菌的MIC分别为7.3、2.1和0.02mm。
{"title":"New biologically active allelochemical from the leaves of Dalbergia Paniculata Roxb","authors":"Ashutosh Kumar Singh, R. Yadava, Ritu Yadav, Satya Prakash Shreevastava","doi":"10.13171/mjc02301311676singh","DOIUrl":"https://doi.org/10.13171/mjc02301311676singh","url":null,"abstract":"A new biologically active Allelochemical 3,5,7,3’,4’-pentahydroxyflavone-3<em>-O-β</em>-<em>D </em>xylopyranosyl -(1→4)- <em>β-D</em>-glucopyranosyl-4<sup>’</sup>-<em>O-α-</em>L-arabinoside (<strong>A</strong><sub>1</sub><strong>) </strong>whose m.p. is 340–345 <sup>0</sup>C, m.f. [M<sup>+</sup>] 728 (EIMS) was isolated from methanolic leaf extracts of<strong> </strong><em>Dalbergia paniculata</em> Roxb. It was characterized by several color reactions, spectral analysis FTIR, <sup>1</sup>H-NMR, GC-MS, and chemical degradations. The results of the antimicrobial activity of <strong>(A<sub>1</sub>) </strong>at high concentration (100µg/mL) was 20, 17, and 15 mm zone of inhibition against <em>E. coli</em>, <em>B. cereus, </em>and <em>S. aureus aeruginosa, </em>respectively. The data demonstrated that the antimicrobial activity of CH<sub>3</sub> OH soluble fraction <strong>(A<sub>1 </sub>) </strong>at all concentrations was highest against <em>E. coli</em> and lowest<em> S. aureus.</em> <em>E. coli</em>, <em>B. cereus, </em>and <em>S. aureus aeruginosa, </em>respectively 7.3, 2.1, and 0.02mm, MIC was defined as the minimum concentration of assayed samples that inhibited the visible growth of the tested microorganism<em>. </em>MIC in <em>E. coli</em>, <em>B. cereus, </em>and <em>S. aureus aeruginosa </em>was 7.3, 2.1, and 0.02mm, respectively.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"2006 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88135234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-22DOI: 10.13171/mjc02301231672das
Artish Roy, Aayushi Chanderiya, Hemlata Dangi, Arunesh Mishra, Pratibha Mishra, S. Kashaw, R. Das
In this research, we have described a facile and user-friendly protocol for the formation of 2((1H-Indole-3yl)(Phenyl)methyl)malononitrile derivatives using a recoverable and efficient TiO2 nanocatalyst. This protocol is simple and incredibly efficient for the synthesis of novel 2((1H-Indole-3yl)(Phenyl)methyl)malononitrile derivatives. Nanoscale TiO2 is used as the catalyst. Since TiO2 has more surface area easily binds with the active site of a reactive molecule and initiates the reaction. At last, TiO2 also recovered as it acts as a catalyst. This multi-component reaction involves indole, malononitrile, and active aldehyde derivatives in the presence of ethanol as solvent and TiO2 as a nanocatalyst. The synthetic methodology employed for multi-component reactions produces substituted 2((1H-Indole-3yl)(Phenyl) methyl) malononitrile derivatives with an environmentally friendly protocol under modest reaction conditions. This study shows that the recoverable and environmentally friendly TiO2 nanocatalyst is an effective material for the synthesis of 2((1H-Indole-3yl) (Phenyl) methyl) malononitrile derivatives with high yields, rapid reaction at room temperature, and effortless product isolation.
{"title":"A one-pot multi-component synthesis of novel 2((1H-Indole-3yl) (Phenyl) methyl) malononitrile derivative by utilizing recoverable and efficient TiO2 nanocatalyst","authors":"Artish Roy, Aayushi Chanderiya, Hemlata Dangi, Arunesh Mishra, Pratibha Mishra, S. Kashaw, R. Das","doi":"10.13171/mjc02301231672das","DOIUrl":"https://doi.org/10.13171/mjc02301231672das","url":null,"abstract":"In this research, we have described a facile and user-friendly protocol for the formation of 2((1H-Indole-3yl)(Phenyl)methyl)malononitrile derivatives using a recoverable and efficient TiO2 nanocatalyst. This protocol is simple and incredibly efficient for the synthesis of novel 2((1H-Indole-3yl)(Phenyl)methyl)malononitrile derivatives. Nanoscale TiO2 is used as the catalyst. Since TiO2 has more surface area easily binds with the active site of a reactive molecule and initiates the reaction. At last, TiO2 also recovered as it acts as a catalyst. This multi-component reaction involves indole, malononitrile, and active aldehyde derivatives in the presence of ethanol as solvent and TiO2 as a nanocatalyst. The synthetic methodology employed for multi-component reactions produces substituted 2((1H-Indole-3yl)(Phenyl) methyl) malononitrile derivatives with an environmentally friendly protocol under modest reaction conditions. This study shows that the recoverable and environmentally friendly TiO2 nanocatalyst is an effective material for the synthesis of 2((1H-Indole-3yl) (Phenyl) methyl) malononitrile derivatives with high yields, rapid reaction at room temperature, and effortless product isolation.","PeriodicalId":18513,"journal":{"name":"Mediterranean Journal of Chemistry","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88462461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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