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Revisiting the predictability of follicular fluid leptin and related adiposity measures for live birth in women scheduled for ICSI cycles: a prospective cohort study 前瞻性队列研究:重新审视卵泡液瘦素和相关脂肪测量指标对计划进行卵胞浆内单精子显微注射(ICSI)周期的妇女活产的预测能力
IF 1.3 Q3 Medicine Pub Date : 2024-01-17 DOI: 10.1186/s43043-024-00164-y
A. Abdelmagied, Alaa A. Makhlouf, Ahmed A. Abdel-Aleem, Safwat A. Mohamed, Ahmed Nasr, Azza Abo Elfadl, Mohammed K. Ali
Our research question is could follicular fluid (FF) leptin solely or contemporaneously with other clinical, biochemical, and sonographic adiposity measures predict the probability of having a live birth during ICSI cycles? This is a prospective cohort study that enrolled infertile women without polycystic ovary syndrome scheduled for ICSI. At baseline, women had an assessment of obesity using different metrics: clinical, serum biochemical, and sonographic. Clinical measures encompassed waist circumference and body mass index. Biochemical evaluation comprised an assessment of the homeostasis model for insulin resistance, visceral adiposity index, and lipid accumulation product. Preperitoneal and subcutaneous abdominal fat were measured using ultrasound and body fat index was calculated. On the day of oocyte retrieval, pooled FF was sampled to assess FF leptin. Our primary outcome was live birth after one fresh embryo transfer cycle. Out of 91 women analyzed in this study, 28 have a live birth (30.8%). No difference in FF leptin concentration was found between women with and without live birth (mean ± SD; 20336 ± 8006 vs 18493 ± 6655 pg/ml; P = 0.2). None of the assessed adiposity markers was a predictor for live birth. Substantially, follicular fluid leptin was positively correlated with insulin resistance in women with and without live birth (r = 0.21, P = 0.04). In logistic regression analysis, the outcome of the prior cycle, the ability to have cryopreserved embryos, and the oocyte maturation index were the predictors for live birth in our study. The present work could not find evidence that follicular fluid leptin, preperitoneal fat, and other evaluated adiposity measures could impact live births after ICSI cycles.
我们的研究问题是,卵泡液(FF)瘦素能否单独或同时与其他临床、生化和超声脂肪测量指标一起预测 ICSI 周期中的活产概率?这是一项前瞻性队列研究,研究对象是计划接受卵胞浆内单精子显微注射(ICSI)的无多囊卵巢综合征的不孕妇女。在基线阶段,研究人员采用临床、血清生化和超声等不同指标对女性进行肥胖评估。临床指标包括腰围和体重指数。生化评估包括胰岛素抵抗稳态模型、内脏脂肪指数和脂质堆积产物的评估。使用超声波测量腹膜前和腹部皮下脂肪,并计算体脂指数。在取卵当天,采集集合 FF 样本以评估 FF 瘦素。我们的主要结果是一个新鲜胚胎移植周期后的活产率。在本研究分析的 91 名妇女中,28 人(30.8%)获得活产。活产和非活产妇女的 FF 瘦素浓度没有差异(平均值 ± SD;20336 ± 8006 vs 18493 ± 6655 pg/ml;P = 0.2)。所评估的脂肪标记物中没有一项是预测活产的指标。在有活产儿和无活产儿的妇女中,卵泡液瘦素与胰岛素抵抗呈显著正相关(r = 0.21,P = 0.04)。在逻辑回归分析中,前一个周期的结果、冷冻胚胎的能力和卵母细胞成熟指数是我们研究中预测活产的因素。本研究未发现卵泡液瘦素、腹膜前脂肪和其他评估的脂肪测量指标会影响卵胞浆内单精子显微注射周期后的活产率。
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引用次数: 0
Second ejaculation produces good quality sperm and blastocyst and decreases the rate of unexpected ICSI cycle: a propensity score-matched analysis 第二次射精可产生优质精子和囊胚并降低卵胞浆内单精子显微注射周期的意外率:倾向得分匹配分析
IF 1.3 Q3 Medicine Pub Date : 2024-01-08 DOI: 10.1186/s43043-024-00165-x
Xiaohui Zhang, Shikai Wang, Yueyue Huang, Xianbao Mao, Zhengda Li, Pingpin Wei, Liangshi Chen, Dawen Li, Lintao Xue
Second ejaculation can influence sperm quality which may define the first-line treatment. The purpose of this study was to evaluate the effectiveness of a second ejaculation in decreasing the unexpected intracytoplasmic sperm injection (ICSI) rate by a propensity score-matched (PSM) analysis. Patients who were projected to undergo IVF were included between January 2016 and November 2021 in this monocentric, retrospective analysis. 2782 patients included in the study, 143 and 2639 patients were non-randomized in the unexpected ICSI and IVF groups, respectively. One hundred fourteen patients with unexpected ICSI produced two semen samples on the day of ovum pick-up. After 1:4 PSM, we matched 61 patients in the second ejaculation IVF group to 238 patients in the conventional IVF group. Outcomes of sperm quality, fertilization rate, embryo quality, and pregnancy were compared. Second ejaculation significantly improved sperm concentration, progressive motility before and after sperm swim-up, total progressive motility sperm count after swim-up, and decreased sperm DNA fragmentation (SDF). Sixty-one of 114 (53.5%) unexpected ICSI couples had enough total progressive motility sperm for IVF with the second ejaculation. There were no differences in basic clinical characteristics between couples in second ejaculation IVF and matched-conventional IVF group. For the two groups, no differences were observed in IVF outcomes. However, a significant increase in good-quality blastocyst rate was observed for second-ejaculation IVF couples. Univariate and multivariate linear regression analysis also confirmed that the second ejaculation was an independent risk factor for the good quality blastocyst rate. Second ejaculation could be an economical and secure alternative to get good quality sperm, and blastocyst and decrease the rate of unexpected ICSI. Multicenter studies should be conducted to confirm the potential advantages of using second ejaculation IVF in effectively reducing the rate of ICSI.
二次射精可影响精子质量,而精子质量可确定一线治疗方案。本研究旨在通过倾向得分匹配(PSM)分析,评估二次射精在降低卵胞浆内单精子显微注射(ICSI)意外率方面的有效性。在这项单中心回顾性分析中,纳入了2016年1月至2021年11月期间预计接受体外受精的患者。研究共纳入2782名患者,意外ICSI组和IVF组分别有143名和2639名患者未进行随机分组。114名意外ICSI患者在取卵当天获得了两份精液样本。经过 1:4 PSM 后,我们将第二次射精试管婴儿组的 61 名患者与常规试管婴儿组的 238 名患者进行了配对。比较了精子质量、受精率、胚胎质量和妊娠率。二次射精明显提高了精子浓度、精子游动前和游动后的渐进活力、游动后的总渐进活力精子数,并减少了精子DNA碎片(SDF)。在114对意外的ICSI夫妇中,有61对(53.5%)在第二次射精后获得了足够的总精子数,可以进行试管婴儿。第二次射精试管婴儿组与匹配的常规试管婴儿组在基本临床特征方面没有差异。两组的试管婴儿结果也无差异。不过,二次射精试管婴儿夫妇的优质囊胚率明显增加。单变量和多变量线性回归分析也证实,第二次射精是影响优质囊胚率的一个独立风险因素。二次射精可能是获得优质精子和囊胚的一种经济、安全的选择,并能降低意外的 ICSI 率。应开展多中心研究,以证实二次射精试管婴儿在有效降低 ICSI 率方面的潜在优势。
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引用次数: 0
Effect of health education program on knowledge, stress, and satisfaction among infertile women undergoing in vitro fertilization injection 健康教育计划对接受体外受精注射的不孕妇女的知识、压力和满意度的影响
IF 1.3 Q3 Medicine Pub Date : 2024-01-02 DOI: 10.1186/s43043-023-00160-8
Heba M. Mohamed, Treza S. Badia, Shimaa A. Khalaf, Saleh O. Abdullah, Tarek A. Farghaly, Ahmed N. Fetih, Shimaa Elwardany Aly
Stress and dissatisfaction are common issues among patients undergoing in vitro fertilization (IVF). The process of IVF can be emotionally and psychologically challenging, leading to stress, anxiety, and depression in patients. This can be exacerbated by factors such as the length of infertility, the uncertainty of the outcome, and the financial burden of treatment. Additionally, the physical demands of the treatment, the side effects of medication, and the fear of failure can contribute to dissatisfaction and emotional strain in IVF patients. This pre-post intervention study design aimed to evaluate the effect of a health education program on knowledge, stress, and satisfaction among 100 infertile women undergoing IVF attending the Woman’s Health Hospital’s infertility outpatient clinic and IVF unit at Assiut University. Knowledge and stress were measured by women’s knowledge about IVF and the perceived stress scale, respectively. The satisfaction was measured using the Scale of Patient Satisfaction about IVF. There is a marked improvement in the knowledge of infertile women, with a significant reduction in their stress levels after the health education program. Furthermore, the satisfaction scores of the women who participated in the program improved significantly. The health education program demonstrated a positive impact on knowledge, stress levels, and satisfaction among infertile women undergoing IVF. These findings highlight the positive impact of the program on the participants and emphasize the importance of continuous educational programs regarding IVF to improve knowledge, decrease stress levels, and increase their overall satisfaction with the treatment.
压力和不满是体外受精(IVF)患者的常见问题。体外受精的过程可能对患者的情绪和心理造成挑战,从而导致压力、焦虑和抑郁。不孕症的时间长短、治疗结果的不确定性以及治疗的经济负担等因素都会加剧这种状况。此外,治疗对身体的要求、药物的副作用以及对失败的恐惧也会导致试管婴儿患者的不满和情绪紧张。本研究设计了一项前-后干预研究,旨在评估健康教育计划对阿苏特大学妇女健康医院不孕不育门诊和试管婴儿科 100 名接受试管婴儿治疗的不孕妇女的知识、压力和满意度的影响。知识和压力分别通过妇女对试管婴儿的了解程度和感知压力量表进行测量。满意度则通过试管婴儿患者满意度量表进行测量。在健康教育计划之后,不孕妇女的知识水平明显提高,压力水平显著降低。此外,参加该计划的妇女的满意度得分也有了显著提高。健康教育计划对接受体外受精的不孕妇女的知识水平、压力水平和满意度都产生了积极影响。这些研究结果凸显了该项目对参与者的积极影响,并强调了持续开展试管婴儿相关教育项目以提高知识水平、降低压力水平并提高她们对治疗的整体满意度的重要性。
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引用次数: 0
The randomized clinical trial trustworthiness crisis 随机临床试验的可信度危机
IF 1.3 Q3 Medicine Pub Date : 2024-01-02 DOI: 10.1186/s43043-023-00161-7
Furqan A. Butt, Mohammad Fawzy, Bassel H. Al Wattar, Aurora Bueno-Cavanillas, Khalid S. Khan, Yacoub Khalaf
The rising number of retracted randomised clinical trials (RCTs) is a concern over their trustworthiness. In today's digital landscape electronic observational data is easily accessible for research purposes. This emerging perspective, in tandem with the growing scrutiny of RCT credibility, may steer some researchers towards favouring non-randomized studies. It is crucial to emphasize the ongoing need for robust RCTs, shedding light on the areas within trial design that require enhancements and addressing existing gaps in trial execution. Evidence-based medicine pivots on the nexus between empirical medical research and the theoretical and applied facets of clinical care. Healthcare systems regularly amass patient data, creating a vast reservoir of information. This facilitates large-scale observational studies, which may appear as potential substitutes for RCTs. These large-scale studies inherently possess biases that place them a notch below randomized evidence. Honest errors, data manipulation, lapses in professionalism, and methodological shortcomings tarnish the integrity of RCTs, compromising trust in trials. Research institutions, funding agencies, journal editors and other stakeholders have the responsibility to establish robust frameworks to prevent both deliberate and inadvertent mishandling of RCT design, conduct and analysis. Systematic reviews that collate robust RCTs are invaluable. They amalgamate superior evidence instrumental in improving patient outcomes via informed health policy decisions. For systematic reviews to continue to retain trust, validated integrity assessment tools must be developed and routinely applied. This way it will be possible to prevent false or untrustworthy research from becoming part of the recommendations based on the evidence. High-quality RCTs and their systematic reviews play a crucial role in acquiring valid and reliable evidence that is instrumental in improving patient outcomes. They provide vital information on healthcare effectiveness, and their trustworthiness is key to evidence-based medicine.
被撤回的随机临床试验(RCT)数量不断增加,令人担忧其可信度。在当今的数字化时代,电子观察数据很容易被用于研究目的。这种新出现的观点,加上对随机临床试验可信度日益严格的审查,可能会引导一些研究人员倾向于非随机研究。我们必须强调目前对可靠的 RCT 的需求,揭示试验设计中需要改进的领域,并解决试验执行中的现有差距。循证医学的关键在于实证医学研究与临床护理的理论和应用之间的联系。医疗保健系统定期收集患者数据,形成了一个庞大的信息库。这为大规模观察性研究提供了便利,而观察性研究可能会成为研究性临床试验的潜在替代品。这些大规模研究本身存在偏差,比随机证据低一个等级。诚实错误、数据篡改、专业失误和方法缺陷玷污了 RCT 的诚信,损害了人们对试验的信任。研究机构、资助机构、期刊编辑和其他利益相关者有责任建立健全的框架,防止在 RCT 设计、实施和分析过程中出现有意或无意的不当处理。整理可靠的 RCT 的系统性综述非常宝贵。它们汇集了有助于通过明智的卫生政策决策改善患者治疗效果的优质证据。要想让系统性综述继续获得信任,就必须开发并常规应用经过验证的完整性评估工具。这样才能防止虚假或不可信的研究成为基于证据的建议的一部分。高质量的 RCT 及其系统性综述在获取有效、可靠的证据方面发挥着至关重要的作用,而这些证据对于改善患者的治疗效果至关重要。它们提供了有关医疗保健有效性的重要信息,其可信度是循证医学的关键。
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引用次数: 0
An insight into the associated factors with recurrent endometriomas after surgical excision 洞察手术切除后子宫内膜异位症复发的相关因素
IF 1.3 Q3 Medicine Pub Date : 2024-01-02 DOI: 10.1186/s43043-023-00163-5
Faezeh Fashkhami, Ali Beykian
Atwa et al.’s study shed light on endometrioma management and factors affecting recurrence. However, the exclusion of open ovarian surgery patients and the potential impact of laparoscopic surgery on ovarian reserve and outcomes warrant consideration. Including both surgical approaches in future studies would enable a comprehensive assessment of their effectiveness and influence on endometrioma recurrence, enhancing our understanding of surgical excision outcomes.
Atwa 等人的研究揭示了子宫内膜异位症的治疗方法和影响复发的因素。然而,开腹卵巢手术患者被排除在外以及腹腔镜手术对卵巢储备和结果的潜在影响值得考虑。将这两种手术方法纳入今后的研究将能全面评估它们的效果和对子宫内膜瘤复发的影响,从而加深我们对手术切除结果的理解。
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引用次数: 0
Association between ambient particulate matter and semen quality parameters: a systematic review and meta-analysis 环境颗粒物与精液质量参数之间的关系:系统回顾与荟萃分析
IF 1.3 Q3 Medicine Pub Date : 2024-01-02 DOI: 10.1186/s43043-023-00162-6
Seyed Sobhan Bahreiny, Mohammad-Navid Bastani, Mohammad Reza Dabbagh, Hamid Ghorbani, Mojtaba Aghaei, Mehdi Zahedian, Reza Mohammadpour Fard
The adverse consequences of ambient particulate matter (PM) on human health have been extensively studied. However, the association between PM2.5 and PM10 μm, two common sizes of particulate matter, and semen quality remains a subject of debate. This systematic review and meta-analysis aim to investigate the relationship between ambient PM2.5 and PM10 μm exposure and semen quality parameters. A systematic literature search was conducted using electronic databases to identify relevant studies investigating the association between (PM2.5 μm and PM10 μm) exposure and semen quality, covering the period from January 2000 to April 2023. Standard mean difference (SMD) was used to calculate pooled effect estimates with 95% confidence intervals (CIs). Furthermore, meta-regression and subgroup analyses provided additional insight into potential factors contributing to heterogeneity. The meta-analysis included a comprehensive review of nine studies with a total of 6264 participants. The findings demonstrated a significant negative correlation between ambient exposure to PM2.5 μm and PM10 μm and various parameters related to semen quality. The analysis revealed that PM2.5 exposure was linked to reduced semen volume (SMD = −0.028; 95% CI −0.055 to −0.01), total sperm count (SMD = −0.027; 95% CI −0.052 to -0.02), sperm motility (SMD = −0.156; 95% CI −0.26 to -0.04), and progressive motility (SMD = −0.194; 95% CI −0.38 to −0.01). Likewise, exposure to PM10 was associated with decreased sperm concentration (SMD = −0.036; 95% CI −0.06 to −0.01) and sperm motility (SMD = −0.93; 95% CI −0.15 to −0.02). This systematic review and meta-analysis demonstrate a consistent negative association between ambient PM10 and PM2.5 μm exposure and semen quality parameters. The findings suggest that increased levels of ambient particulate matter may have an adverse influence on sperm count and motility. The results highlight the importance of addressing environmental air pollution as a potential risk factor for male reproductive health.
环境颗粒物(PM)对人类健康的不利影响已被广泛研究。然而,PM2.5 和 PM10 μm 这两种常见大小的颗粒物与精液质量之间的关系仍存在争议。本系统综述和荟萃分析旨在研究环境中 PM2.5 和 PM10 μm 暴露与精液质量参数之间的关系。我们使用电子数据库进行了系统性文献检索,以确定调查(PM2.5 μm和PM10 μm)暴露与精液质量之间关系的相关研究,研究时间跨度为2000年1月至2023年4月。标准平均差(SMD)用于计算汇集效应估计值及95%置信区间(CI)。此外,荟萃回归和亚组分析还有助于深入了解导致异质性的潜在因素。荟萃分析全面回顾了九项研究,共有 6264 人参与。研究结果表明,环境中 PM2.5 μm 和 PM10 μm 的暴露量与精液质量的各种相关参数之间存在明显的负相关。分析表明,暴露于PM2.5与精液量减少(SMD = -0.028;95% CI -0.055至-0.01)、精子总数减少(SMD = -0.027;95% CI -0.052至-0.02)、精子活力减少(SMD = -0.156;95% CI -0.26至-0.04)和精子运动性减少(SMD = -0.194;95% CI -0.38至-0.01)有关。同样,暴露于PM10与精子浓度下降(SMD = -0.036;95% CI -0.06至-0.01)和精子活力下降(SMD = -0.93;95% CI -0.15至-0.02)有关。本系统综述和荟萃分析表明,环境 PM10 和 PM2.5 μm 暴露与精液质量参数之间存在一致的负相关。研究结果表明,环境颗粒物水平的增加可能会对精子数量和活力产生不利影响。研究结果凸显了解决环境空气污染这一男性生殖健康潜在风险因素的重要性。
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引用次数: 0
Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers 多囊卵巢综合征的炎症视角:特定介质和标记物的作用
IF 1.3 Q3 Medicine Pub Date : 2023-12-12 DOI: 10.1186/s43043-023-00158-2
Rajen Dey, Koushik Bhattacharya, Asim Kumar Basak, Nimisha Paul, Raktima Bandyopadhyay, Gargi Ray Chaudhuri, Mahuya Patra Purkait, Aniruddha Bhattacharjee, Chaitali Bose, Nandini Shukla, Rama Bhaduri, Soumya Sinha Roy, Alak Kumar Syamal
Polycystic ovary syndrome (PCOS) is indeed one of the most common gynecological endocrine disorders, affecting a significant number of females in their reproductive age. While the exact cause of PCOS is not fully understood, several factors are believed to contribute to its onset. The relationship between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation is complex and not fully understood. While there is evidence to suggest an association between PCOS and inflammation, the exact cause and causal nature of this relationship are still under investigation. Several inflammatory markers, including IL-6 (interleukin-6), TNF-α (tumor necrosis factor-alpha), IL-17 (interleukin-17), CRP (C-reactive protein), NLR (neutrophil-to-lymphocyte ratio), and PLR (platelet-to-lymphocyte ratio), have been studied about PCOS. These markers are substances produced by the immune system in response to inflammation. Increased levels of IL-17, IL-1, and IL-8 were correlated with PCO. CRP to albumin ratio can be employed as a precise bio-marker for PCOS. The neutrophil-to-lymphocyte ratio (NLR) indicates poor cardiovascular health and metabolic syndrome (MS) and can be considered a negative regulator for FSH which indirectly stimulates testosterone production. Platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are also recently found to be associated with PCOS. The literature explaining the underlying mechanisms with specific inflammatory markers and how inflammation relates to PCOS will be highlighted in this review article. It will also discuss the roles of inflammation and the association of different inflammatory markers in the pathogenesis of PCOS, which may usher in a new era in the treatment approach for PCOS.
多囊卵巢综合征(PCOS)是最常见的妇科内分泌疾病之一,影响着大量育龄女性。虽然多囊卵巢综合症的确切病因尚不完全清楚,但有几个因素被认为是导致其发病的原因。多囊卵巢综合症(PCOS)与低度慢性炎症之间的关系十分复杂,尚未完全明了。虽然有证据表明多囊卵巢综合症与炎症有关,但这种关系的确切原因和因果性质仍在调查之中。关于多囊卵巢综合症,已经研究了几种炎症标志物,包括 IL-6(白细胞介素-6)、TNF-α(肿瘤坏死因子-α)、IL-17(白细胞介素-17)、CRP(C 反应蛋白)、NLR(中性粒细胞与淋巴细胞比值)和 PLR(血小板与淋巴细胞比值)。这些标志物是免疫系统在炎症反应时产生的物质。IL-17、IL-1 和 IL-8 水平的升高与多囊卵巢综合症有关。CRP 与白蛋白的比率可作为 PCOS 的精确生物标记。中性粒细胞与淋巴细胞比率(NLR)表明心血管健康状况不佳和代谢综合征(MS),可被视为 FSH 的负调节因子,间接刺激睾酮的产生。最近还发现血小板/淋巴细胞比率(PLR)和平均血小板体积(MPV)与多囊卵巢综合征有关。本综述文章将重点介绍解释特定炎症标志物潜在机制的文献,以及炎症与多囊卵巢综合症的关系。文章还将讨论炎症的作用以及不同炎症标志物在多囊卵巢综合症发病机制中的关联,这可能会开创多囊卵巢综合症治疗方法的新纪元。
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引用次数: 0
Worldwide sperm quality variations between 2000 and 2020: a scoping review 2000 年至 2020 年全球精子质量变化:范围审查
IF 1.3 Q3 Medicine Pub Date : 2023-12-11 DOI: 10.1186/s43043-023-00159-1
Noor Mohammad Alqurna, Zina Mahdi Al-Alami
There is a scarcity of research on male infertility and semen quality worldwide, notably in the Middle East and North Africa (MENA) region. This lack includes temporal comparisons of seminal parameters over decades. The aim of this scoping review is to summarize the articles, published between January 1, 2000, and December 31, 2020, which discuss and describe human semen quality and/or sperm quality in different countries, and/or their alternating patterns through time. The search was done on PubMed, using the following keywords: (((semen[Title/Abstract]) OR (SFA[Title/Abstract])) OR (sperm[Title/Abstract])) AND (country name[Title/Abstract]) with 195 world countries put in the “country name” field one by one along with other filters. The abstracts that fulfilled the inclusion criteria were read thoroughly and summarized. In conclusion, although some semen parameters appear to be stable, semen quality has deteriorated over time. Therefore, various countries must conduct research to characterize their semen quality and its altering patterns throughout time to reach a thorough conclusion.
世界范围内,尤其是中东和北非地区,有关男性不育症和精液质量的研究十分匮乏。这种缺乏包括对几十年来精液参数的时间比较。本范围综述旨在总结 2000 年 1 月 1 日至 2020 年 12 月 31 日期间发表的、讨论和描述不同国家人类精液质量和/或精子质量和/或其时间交替模式的文章。检索在 PubMed 上进行,使用以下关键词:(((精液[标题/摘要])或(SFA[标题/摘要]))或(精子[标题/摘要])。或(精子[标题/摘要]))和(国名[标题/摘要]),在 "国名 "字段中逐一输入世界 195 个国家,并进行其他筛选。对符合纳入标准的摘要进行了全面阅读和总结。总之,虽然精液的某些参数看起来比较稳定,但随着时间的推移,精液质量却在下降。因此,各国必须对其精液质量特点及其随时间变化的模式进行研究,以得出全面的结论。
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引用次数: 0
Enhancing endometrial pathology detection: chromohysteroscopy vs. conventional hysteroscopy in infertility evaluation 增强子宫内膜病理学检测:彩色宫腔镜与常规宫腔镜在不孕症评估中的比较
IF 1.3 Q3 Medicine Pub Date : 2023-11-29 DOI: 10.1186/s43043-023-00157-3
Sangam Jha, Shalini Singh, Jafeesha B. Singh
Endometrial pathology is a recognized contributor to infertility and recurrent implantation failure, but its detection during hysteroscopy, particularly in the absence of visible lesions, is challenging. Chromohysteroscopy, involving the use of methylene blue dye, has shown promise in improving diagnostic accuracy. This interventional cross-sectional study compared the diagnostic accuracy of chromohysteroscopy and conventional hysteroscopy, using histopathology as the gold standard. A total of 100 consenting infertility patients were included, in a sequential step, hysteroscopy followed by chromohysteroscopy using methylene blue dye was performed to enhance the detection of subtle endometrial pathologies. Among the 100 women who underwent diagnostic hysteroscopy, 76 exhibited normal findings, while 24 had abnormal findings. During chromohysteroscopy, 62 cases displayed a light staining pattern, and 38 cases exhibited dark staining. Histopathological analysis of biopsy tissue from the dark-stained areas revealed endometrial pathology in 84.2% (32/38) and normal endometrium in 15.8% (6/38) cases. In contrast, biopsies from the light-stained areas indicated abnormal endometrium in only 3.23% (2/62) cases, with the remaining 96.77% having a normal histology. Chromohysteroscopy demonstrated a significantly higher diagnostic accuracy (92%) for endometrial pathology compared to conventional hysteroscopy (58%). Notably, chromohysteroscopy’s sensitivity was 94.12%, and its specificity was 90.9%. The staining patterns observed during chromohysteroscopy correlated well with histological findings, highlighting its effectiveness in identifying structurally damaged endometrium. Chromohysteroscopy emerges as a valuable diagnostic tool for assessing endometrial pathology, especially in infertility cases. This technique offers superior accuracy compared to conventional hysteroscopy, providing clinicians with a more precise means of diagnosis and potential targeted treatments.
子宫内膜病理是公认的不孕不育和反复植入失败的原因,但在宫腔镜检查中,特别是在没有可见病变的情况下,其检测是具有挑战性的。使用亚甲基蓝染料的彩色宫腔镜在提高诊断准确性方面显示出了希望。本介入横断面研究比较了彩色宫腔镜和常规宫腔镜的诊断准确性,以组织病理学为金标准。共纳入100例同意的不孕症患者,在连续的步骤中,宫腔镜检查和亚甲基蓝染色宫腔镜检查以加强对子宫内膜细微病变的检测。在100名接受诊断性宫腔镜检查的妇女中,76名表现正常,24名表现异常。色宫腔镜检查中,62例显示浅色染色,38例显示深色染色。深色染色区活检组织病理分析显示84.2%(32/38)的子宫内膜病理,15.8%(6/38)的子宫内膜正常。相比之下,仅3.23%(2/62)的病例在浅色染色区活检显示子宫内膜异常,其余96.77%的患者组织学正常。与传统宫腔镜(58%)相比,彩色宫腔镜对子宫内膜病理的诊断准确率(92%)明显更高。值得注意的是,色宫腔镜的敏感性为94.12%,特异性为90.9%。在染色宫腔镜中观察到的染色模式与组织学结果有很好的相关性,突出了其在识别结构性受损子宫内膜方面的有效性。彩色宫腔镜出现作为一个有价值的诊断工具评估子宫内膜病理,特别是在不孕症的情况下。与传统宫腔镜相比,该技术具有更高的准确性,为临床医生提供了更精确的诊断手段和潜在的靶向治疗。
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引用次数: 0
A narrative literature review of remaining male reproductive health concerns as an aspect of persistent/late-onset complications of COVID-19 关于男性生殖健康问题作为COVID-19持续性/晚发性并发症的一个方面的叙述文献综述
IF 1.3 Q3 Medicine Pub Date : 2023-11-22 DOI: 10.1186/s43043-023-00156-4
Azra Allahveisi, Parivash Afradiasbagharani, Mahshid Bazrafkan, Raheleh Kafaeinezhad, Elham Hosseini
Although COVID-19 infection has dropped across the world and SARS-CoV-2 vaccines have been developed, global concerns remain about the disease’s long-term health consequences. The purpose of this research was to review the consequences of SARS-CoV-2 on male health, particularly the reproductive system and the pathogenic mechanisms affecting male infertility. Improving knowledge on these issues may help in considering to which extent some of the remaining concerns should be addressed. The primary target of this disease is the pulmonary system, but reproductive organs may be targeted by the virus. To enter host cells, the virus utilizes both ACE2 and TMPRSS2, which are differentially expressed in the spermatogonial stem, Leydig, and Sertoli cells, thereby providing possible testicular vulnerability. COVID-19-related stress and psychological distress may also affect aspects of male reproductive health. Since some pathological effects of COVID-19 infection and dysregulations are linked to infertility, more attention is needed to determine whether such dysregulations regress following infection decline.
尽管世界各地的COVID-19感染率已经下降,SARS-CoV-2疫苗也已经开发出来,但全球仍对该疾病的长期健康后果感到担忧。本研究的目的是回顾SARS-CoV-2对男性健康,特别是生殖系统的影响以及影响男性不育的致病机制。提高对这些问题的认识可能有助于考虑应在何种程度上解决一些遗留问题。这种疾病的主要目标是肺系统,但生殖器官也可能是病毒的目标。为了进入宿主细胞,病毒利用ACE2和TMPRSS2,这两种蛋白在精原干细胞、间质细胞和支持细胞中有差异表达,从而可能导致睾丸易感。与covid -19相关的压力和心理困扰也可能影响男性生殖健康的各个方面。由于COVID-19感染和失调的一些病理影响与不孕症有关,因此需要更多地关注这些失调是否会在感染下降后消退。
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Middle East Fertility Society Journal
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