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COVID-19 vaccination literacy, attitude and hesitation towards vaccination and vaccination status of pregnant women COVID-19疫苗接种素养、对疫苗接种的态度和犹豫以及孕妇疫苗接种状况
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2022.10.224
Aysegul Kilici, Şahide Akbulut
The study aims to determine COVID-19 vaccine literacy, attitude and hesitation towards the vaccine, and vaccination status of pregnant women in a rural region. This is a cross-sectional study. It was carried out between June 7 – 7 August 2022. 209 pregnant women were included in the study. The mean score of pregnant women was found to be COVID-19 vaccine literacy 2.5±0.4, attitude 3.1±0.8, and hesitation 7.7±6.6. It was found that 12.4% of the pregnant women had COVID-19 disease in their current pregnancy, and 7.2% of them had COVID-19 disease in the first trimester. It was determined that 34.4% of the pregnancy had a single dose, 30.2% had two doses, and most of them were BioNTech vaccines. Vaccine literacy was determined to be higher in pregnant women who are working, have social security, have a higher income than their expenses and have a master's degree. Those who are married, have social security, and have a female baby have a positive attitude for vaccines. There was a positive significant relationship between COVID-19 vaccine literacy and attitude, and a negative significant relationship between COVID-19 vaccine literacy and hesitancy. It was discovered that COVID-19 vaccine literacy is moderate, vaccination rates are low, and vaccination literacy influences vaccination attitudes and hesitation.
本研究旨在了解某农村地区孕妇的COVID-19疫苗素养、对疫苗的态度和犹豫以及疫苗接种状况。这是一项横断面研究。它在2022年6月7日至8月7日之间进行。209名孕妇参与了这项研究。孕妇新冠肺炎疫苗识字率平均得分为2.5±0.4,态度平均得分为3.1±0.8,犹豫平均得分为7.7±6.6。结果发现,12.4%的孕妇在妊娠期感染新冠病毒,7.2%的孕妇在妊娠早期感染新冠病毒。结果表明,34.4%的孕妇接种了单剂疫苗,30.2%的孕妇接种了两剂疫苗,其中大多数是BioNTech疫苗。在有工作、有社会保障、收入高于支出、拥有硕士学位的孕妇中,疫苗知识普及程度较高。已婚、有社会保障、有女婴的人对疫苗持积极态度。疫苗素养与态度呈显著正相关,与犹豫呈显著负相关。发现新冠肺炎疫苗识字率中等,疫苗接种率低,疫苗识字率影响疫苗接种态度和犹豫。
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引用次数: 0
Potential cytotoxic effects of borax alone and in combination with irinotecan on YKG1 glioblastoma cell-line 硼砂单独和联合伊立替康对YKG1胶质母细胞瘤细胞系的潜在细胞毒性作用
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2022.11.253
Y. Yuksel, S. Çelik, E. Aslan, M. Tosun, M. Uysal, M. Pektaş
Glioblastoma Multiforme (GBM), which is a common and primary brain tumor in adults, is an important cause of death worldwide as an aggressive and treatment-resistant cancer tumor. In this cell culture study, the apoptotic and anti-proliferative effects of borax and irinotecan at different doses, alone or in combination, were investigated in the YKG1 cell line. Cytotoxic activities were analyzed by MTT method and TUNEL staining after 24th and 48th hours of incubation with borax administered at doses of 1mg and 3mg per ml; irinotecan 50mM and 100mM. Both irinotecan and borax have been shown to induce apoptosis when used alone, and thus cause anti-proliferation. It was determined that these effects were potentiated by the combined application of the agents. In addition, it was determined that this effect in combined applications was more pronounced after 48 hours and at higher doses. In light of the data obtained, the combination of irinotecan with borax to increase the cytotoxic effect of irinotecan, which is used in many different cancer types, can be tried in further prospective studies.
多形性胶质母细胞瘤(GBM)是一种常见的成人原发性脑肿瘤,是一种侵袭性和治疗耐药的恶性肿瘤,是世界范围内导致死亡的重要原因。在本细胞培养研究中,研究了不同剂量硼砂和伊立替康单独或联合使用对YKG1细胞株的凋亡和抗增殖作用。分别给硼砂1mg / ml和3mg / ml,用MTT法和TUNEL染色分析孵育24、48小时后的细胞毒活性;伊立替康50mM和100mM。伊立替康和硼砂在单独使用时均可诱导细胞凋亡,从而引起抗增殖。结果表明,这两种药物的联合应用增强了这些效果。此外,经确定,在联合应用中,这种效果在48小时后和更高剂量时更为明显。根据获得的数据,伊立替康与硼砂联合使用以增加伊立替康的细胞毒性作用,可以在进一步的前瞻性研究中进行尝试,这种方法用于许多不同类型的癌症。
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引用次数: 0
Parental temperament characteristics of juvenile delinquents 少年犯的父母气质特征
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.08.173
Yavuz Yilmaz, Ayla Cicek
Criminal behavior in children emerges as a result of a complex process. If the criminal behavior is repetitive and preventive interventions are not applied, it can also lead to the emergence of criminal behavior in adulthood. In our study, we aimed to compare the parental temperament characteristics of juvenile delinquents with those of non-offending children of similar age and gender. The study group included parents of 69 juvenile delinquents aged between 12 and 15, while the control group consisted of parents of 73 non-offending children of the same age range. Data was collected using a demographic information form prepared by researchers and the TEMPS-A (Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionnaire) Temperament Scale. The study group included 37 fathers and 32 mothers, while the control group included 40 fathers and 33 mothers. Parents in the study group had less education than those in the control group, and psychopathology was more common. The study group's parents experienced more legal issues on average. In comparison to the control group, fathers in the study group scored higher for cyclothymic temperament, hyperthymic temperament, and irritable temperament. Compared to the control group, mothers in the study group scored higher on all temperamental variables. The fathers' assessments of their depressive and anxious temperaments did not differ significantly. Fathers in the study group scored higher on the cyclothymic, hyperthymic, and irritable temperament scales. There was a considerable difference in the prevailing temperament type between the groups. Moms in the research group had significantly higher temperament scores than those in the control group.
儿童的犯罪行为是一个复杂过程的结果。如果犯罪行为是重复的,不采取预防性干预措施,也可能导致成年后犯罪行为的出现。在本研究中,我们的目的是比较青少年犯罪与相同年龄和性别的非犯罪儿童的父母气质特征。研究小组包括69名年龄在12岁至15岁之间的少年犯的父母,而对照组由73名年龄相同的非犯罪儿童的父母组成。数据收集使用研究者准备的人口统计信息表和TEMPS-A气质量表(孟菲斯、比萨、巴黎、圣地亚哥自问卷气质评价)。研究小组包括37名父亲和32名母亲,而对照组包括40名父亲和33名母亲。实验组的父母受教育程度低于对照组,精神病理更常见。研究小组的父母平均经历了更多的法律问题。与对照组相比,研究组的父亲在循环胸腺气质、亢奋胸腺气质和易怒气质方面得分更高。与对照组相比,研究组的母亲在所有气质变量上得分都更高。父亲对他们抑郁和焦虑性格的评估没有显著差异。研究小组的父亲在循环胸腺、亢奋和易怒气质量表上得分更高。两组之间的主流气质类型有相当大的差异。研究组妈妈的气质得分明显高于对照组妈妈。
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引用次数: 0
What is the prevalence of plantar tendon used as tendon graft in the Somali population? 在索马里人口中,足底肌腱作为肌腱移植的流行率是多少?
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.10.203
Ibrahim Etli, Hasan May, Engin Cicek, Cihan Celik, Abdullahi Mohamed
The plantar muscle is fusiform, attaching to the calcaneus, starting behind the knee. Plantaris muscle formation has been reported in humans at a rate approaching 90%. It is frequently preferred for tendon grafting and tendon transfer in hand surgery and Achilles tendon injuries. In this study, our goal is to investigate the frequency of the presence of the plantar muscle in the Somali population. We retrospectively analyzed 607 knee MRI scans performed at Recep Tayyip Erdoğan Training and Research Hospital in Mogadishu between January 2019 and March 2022. The clinical and demographic characteristics of the patients were recorded. Patients with muscle trauma and previous surgery involving muscles, proximal tibia fracture surgery, and soft tissue tumors were dropped out of the study. 469 (77.3%) of these patients were male and 138 (22.7%) were female.182 (72%) of the male patients with right MRI saw plantaris while 68 (28%) did not. While plantaris was seen in 183 (83.5%) of the male patients who underwent left-sided MRI, plantaris was not seen in 30 (16.5%). Plantaris was seen in 62 (79.5%) of the female patients who had right-sided MRI, while plantaris was not seen in 16 (20.5%). Left plantar was present in 55 (91.7%) and absent in 5 (8.3%) female patients who underwent left-sided MRI. Since the plantaris muscle is used as a tendon graft, pre-op evaluation of its presence is important in terms of surgery and can change the surgical procedure. The presence of the plantar tendon can be revealed by using knee MRI in the Somali population living in the African continent.
足底肌呈梭状,与跟骨相连,从膝盖后面开始。据报道,人类的足底肌形成率接近90%。在手部手术和跟腱损伤中,它通常是首选的肌腱移植和肌腱转移。在这项研究中,我们的目标是调查索马里人口中足底肌存在的频率。我们回顾性分析了2019年1月至2022年3月期间在摩加迪沙的雷杰普·塔伊普Erdoğan培训和研究医院进行的607次膝关节MRI扫描。记录患者的临床和人口学特征。有肌肉创伤和既往手术涉及肌肉、胫骨近端骨折手术、软组织肿瘤的患者被排除在研究之外。其中男性469例(77.3%),女性138例(22.7%)男性患者右侧MRI见足底炎者占72%,未见足底炎者68例(28%)。在接受左侧MRI检查的男性患者中,有183例(83.5%)出现足底炎,30例(16.5%)未见足底炎。右侧MRI检查的女性患者中有62例(79.5%)可见跖趾,16例(20.5%)未见跖趾。接受左侧MRI检查的女性患者中,55例(91.7%)存在左足底,5例(8.3%)未见左足底。由于足底肌被用作肌腱移植物,术前评估足底肌的存在对手术来说很重要,并且可以改变手术程序。足底肌腱的存在可以通过使用膝盖MRI在索马里人口生活在非洲大陆揭示。
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引用次数: 0
The relationship of trunk control with balance, upper extremity and lower extremity functions in stroke patients 脑卒中患者躯干控制与平衡、上肢及下肢功能的关系
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.08.160
Zekiye Kirmaci, Nevin Ergun
The center of the body is the trunk. For distal extremity movements, balance, and functional tasks, proximal trunk control is crucial. The aim of the study is to examine the relationship of trunk control with balance, upper extremity and lower extremity functions in stroke patients. Thirty-six stroke patients were included in this cross-sectional descriptive study. Trunk control was assessed using the Trunk Impairment Scale (TIS), Berg Balance Scale (BBS) was used for balance evaluation, Fugl-Meyer Lower Extremity Scale (FML) was used for lower extremity function evaluation, Fugl-Meyer Upper Extremity Scale (FMU) was used for upper extremity function evaluation. The mean age of the included stroke patients was 62±11 years. There was a moderate negative correlation between TIS and BBS (r=-0.610, p<0.01). A moderate negative correlation was found between TIS and FML (r=-0.520, p=0.001). A low negative correlation was found between TIS and FMU (r=-0.372, p=0.025). Trunk control affects balance, lower extremity and upper extremity function. In the treatment of stroke patients, exercise approaches for trunk control should be added to rehabilitation programs in addition to basic neurophysiological approaches.
身体的中心是躯干。对于远端肢体运动、平衡和功能性任务,近端躯干控制是至关重要的。本研究旨在探讨脑卒中患者躯干控制与平衡、上肢及下肢功能的关系。本横断面描述性研究纳入了36例脑卒中患者。躯干控制采用躯干损伤量表(TIS)评估,平衡评价采用Berg平衡量表(BBS),下肢功能评价采用Fugl-Meyer下肢功能量表(FML),上肢功能评价采用Fugl-Meyer上肢功能量表(FMU)。纳入的脑卒中患者平均年龄为62±11岁。TIS与BBS呈中度负相关(r=-0.610, p<0.01)。TIS与FML呈中度负相关(r=-0.520, p=0.001)。TIS与FMU呈低负相关(r=-0.372, p=0.025)。躯干控制影响平衡、下肢和上肢功能。在脑卒中患者的治疗中,除了基本的神经生理学方法外,还应在康复计划中加入运动方法来控制躯干。
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引用次数: 0
Assessment of enteral nutrition through feeding stomas or gastric tubes in digestive surgery 消化道手术中通过喂养口或胃管进行肠内营养的评估
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2022.06.129
C. Finaritra, A. Rakotondrainibe, F. Rasoaherinomenjanahary, A. Rajaonera, L. Samison
Ostomy feeding remains a reference approach for enteral nutritional assistance. In Madagascar, the techniques are still conventional surgical procedures due to the lack of adequate endoscopic equipment. This study aims to evaluate the benefits and risks of enteral nutrition with a two-week follow-up. Included patients who had benefited from enteral nutrition by tube feeding using nasogastric, gastrostomy, and jejunostomy tubes over six months in Joseph Ravoahangy Andrianavalona Hospital. Prevalence, age and gender, current body mass index (BMI), weight, nutritional grade, initial pathology, psychological status, comorbidities, type of feeding stoma, and the surgical technique (gastrostomy or jejunostomy) were studied. After 15 days, the effectiveness of enteral nutrition was assessed using BMI, serum albumin, C-Reactive Protein (CRP) level, as well as postoperative complications and quality of life. The patient's outcome on the 15th day has been determined. The Chi-square test analyzed the associations and Mann Whitney test compared the effects of enteral nutrition by ostomy and gastric tube use. Forty-two patients were included, aged 47(17-78). The sex ratio was 0.5. Initially, the body mass index was 17(12-23) kg/m², the serum albumin value 3.4 (2.5-4.7) gr/dl with a median CRP level of 16 (2-74.2) mg/l. Nutritional assistance resulted in a weight variation between baseline and 15th day. Comparing enteral nutrition by ostomy and gastric tube, only variation of C Reactive Protein on the 15th day has a significative difference. Mortality was 33% (gastrostomy), 31% (jejunostomy), 24% (nasogastric tube). Nutritional support and the choice of ostomy or gastric tube for enteral nutrition were not associated with mortality. The effectiveness of nutritional assistance is still questionable in this study if the results are more promising in the literature. The death rate linked to the initial pathology and the general state of the patients is still considerable, hence the interest in decision-making in multidisciplinary consultation meetings.
造口喂养仍然是肠内营养辅助的参考方法。在马达加斯加,由于缺乏足够的内窥镜设备,这些技术仍然是传统的外科手术。本研究旨在通过为期两周的随访来评估肠内营养的益处和风险。包括在Joseph Ravoahangy Andrianavalona医院通过鼻胃管、胃造口管和空肠造口管喂养6个月以上受益于肠内营养的患者。研究患者的患病率、年龄和性别、目前的体重指数(BMI)、体重、营养等级、初始病理、心理状态、合并症、喂养口类型和手术技术(胃造口术或空肠造口术)。15天后,通过BMI、血清白蛋白、c反应蛋白(CRP)水平以及术后并发症和生活质量评估肠内营养的有效性。患者在第15天的预后已经确定。卡方检验分析相关性,Mann Whitney检验比较造口和胃管使用肠内营养的效果。纳入42例患者,年龄47岁(17-78岁)。性别比为0.5。最初,体重指数为17(12-23)kg/m²,血清白蛋白值为3.4 (2.5-4.7)gr/dl,中位CRP水平为16 (2-74.2)mg/l。营养援助导致基线和第15天之间的体重变化。对比造口和胃管肠内营养,只有C反应蛋白在第15天的变化有显著性差异。死亡率分别为33%(胃造瘘)、31%(空肠造瘘)和24%(鼻胃管造瘘)。营养支持和选择造口或胃管进行肠内营养与死亡率无关。如果研究结果在文献中更有希望,那么营养辅助的有效性在本研究中仍然值得怀疑。死亡率与最初的病理和病人的一般状态仍然是相当可观的,因此在多学科会诊会议决策的兴趣。
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引用次数: 0
Non-alcoholic fatty liver disease and sleep quality: a single center cross-sectional survey study 非酒精性脂肪肝与睡眠质量:一项单中心横断面调查研究
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2022.08.203
Z. Sargin, Guray Ceylan
Sleep-wake disorders are probably a part of Nonalcoholic Fatty Liver Disease (NAFLD) etiology. This study aimed to evaluate the relationship between NAFLD and the Pittsburgh Sleep Quality Index (PSQI) components. Sleep quality was assessed by the PSQI, which comprised seven components. Participants diagnosed with hepatic steatosis using ultrasonographic imaging and healthy volunteers were given the questionnaire. The percentage of subjects with poor sleep quality was noticeably higher in the NAFLD patients than in the non-NAFLD control group (OR: 4.58, 95% CI: 2.67-7.85) (p<0.001). Compared to the control group, the NAFLD group reported shorter sleep duration (p=0.044), a longer sleep onset delay (p<0.001), worse subjective sleep quality (p<0.001), a higher percentage of subjects with sleep disturbances (p<0.001), a higher percentage of subjects using hypnotic drugs (p=0.009), and a higher percentage of subjects with daytime dysfunction (p<0.001). When the subjects were split into two groups based on gender, global PSQI sleep quality and subjective sleep quality were significantly worse in both genders with NAFLD than in the non-NAFLD group (p<0.001). The sleep onset delay of the NAFLD group was substantially longer in males (p=0.002) and females (p<0.001) compared to controls. Sleep disturbances were significantly higher in both sexes with NAFLD compared to controls (p<0.001). The rate of those with daytime dysfunction in the NAFLD group was considerably higher in both genders compared to the non-NAFLD group (p=0.001). Only among the male patients in the NAFLD group the prevalence of hypnotic drug use was substantially greater (p=0.033) than in the non-NAFLD group. Poor sleep was associated with NAFLD in both genders.
睡眠觉醒障碍可能是非酒精性脂肪性肝病(NAFLD)病因的一部分。本研究旨在评估NAFLD与匹兹堡睡眠质量指数(PSQI)成分之间的关系。睡眠质量由PSQI评估,由七个部分组成。经超声诊断为肝脂肪变性者和健康志愿者填写问卷。NAFLD患者睡眠质量差的比例明显高于非NAFLD对照组(OR: 4.58, 95% CI: 2.67-7.85) (p<0.001)。与对照组相比,NAFLD组睡眠时间较短(p=0.044),睡眠开始延迟时间较长(p<0.001),主观睡眠质量较差(p<0.001),睡眠障碍比例较高(p<0.001),使用催眠药物的比例较高(p=0.009),日间功能障碍比例较高(p<0.001)。将受试者按性别分为两组时,NAFLD患者的PSQI总体睡眠质量和主观睡眠质量均显著低于非NAFLD患者(p<0.001)。与对照组相比,NAFLD组男性(p=0.002)和女性(p<0.001)的睡眠开始延迟明显更长。与对照组相比,两性NAFLD患者的睡眠障碍明显更高(p<0.001)。与非NAFLD组相比,NAFLD组中白天功能障碍的发生率在两性中都明显更高(p=0.001)。只有NAFLD组男性患者使用催眠药物的比例明显高于非NAFLD组(p=0.033)。无论男女,睡眠不足都与NAFLD有关。
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引用次数: 0
Our treatment outcomes in bartholin cysts or abscesses 我们的治疗结果是巴托林囊肿或脓肿
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.04.055
Nurcan Yoruk
The purpose of this study was to examine the outcomes of Bartholin abscess or cyst surgery, silver nitrate therapy, and cyst or abscess excision in terms of recurrence, duration of the procedure, and healing times. The files of 100 patients treated in our hospital for Bartholin cysts or abscesses between March 2022 and December 2022 were reviewed retrospectively. The patients’ demographic characteristics were recorded. Demographic data, the location and size of Bartholin abscesses, complaints at presentation, and cases with recurrence were noted. The patients were divided into three groups according to the treatment applied and were compared with one another, especially in terms of recurrence, operative time, and recovery time. Group 1 consisted of those who underwent drainage due to Bartholin cyst or abscess, Group 2 of those treated with silver nitrate, and Group 3 of those who underwent cyst excision. Recurrence was detected in 12 (40%) of the cases in Group 1. Relapsed cases were treated with silver nitrate. Recurrence was observed in only one patient in the group treated with silver nitrate (Group 2). Bartholin cyst excision was performed on that patient. Mean operation times were 2.80 min in Group 1, 4.40 min in Group 2, and 23 min in Group 3 (p=0.0001). Mean recovery times were 3.37±0.49 days in Group 1, 6.13±0.73 days in Group 2, and 13.70±2.09 days in Group 3 (p=0.0001). A comparison of the patients in all three groups revealed that the recurrence rate was higher in the group receiving abscess drainage. While recurrence was observed in only one patient in the silver nitrate group, no recurrence occurred in the cyst excision group (p<0.001). This study emphasizes that silver nitrate application is a simple practical method that can be performed using local anesthesia, and involving minimal scar tissue, a faster procedure time, and faster recovery.
本研究的目的是检查Bartholin脓肿或囊肿手术、硝酸银治疗和囊肿或脓肿切除术在复发、手术时间和愈合时间方面的结果。回顾性分析我院2022年3月至2022年12月收治的100例Bartholin囊肿或脓肿患者的资料。记录患者的人口统计学特征。我们记录了患者的人口统计资料、Bartholin脓肿的位置和大小、就诊情况和复发情况。根据所采用的治疗方法将患者分为三组,并在复发、手术时间、恢复时间等方面进行比较。第1组为因Bartholin囊肿或脓肿进行引流的患者,第2组为硝酸银治疗的患者,第3组为囊肿切除的患者。第1组有12例(40%)复发。复发病例用硝酸银治疗。在硝酸银治疗组(2组)中,只有1例患者复发。该患者接受了Bartholin囊肿切除术。1组平均手术时间2.80 min, 2组平均手术时间4.40 min, 3组平均手术时间23 min (p=0.0001)。1组平均恢复时间为3.37±0.49 d, 2组为6.13±0.73 d, 3组为13.70±2.09 d (p=0.0001)。三组患者的比较显示,接受脓肿引流组的复发率较高。硝酸银组只有1例患者复发,而囊肿切除组无复发(p<0.001)。本研究强调硝酸银的应用是一种简单实用的方法,可以在局部麻醉下进行,并且涉及的疤痕组织最小,手术时间更快,恢复更快。
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引用次数: 0
Short-term comparison of intraarticular administration of IL-1 receptor antagonist and platelet-rich plasma for osteoarthritis treatment 关节内给药IL-1受体拮抗剂和富血小板血浆治疗骨关节炎的短期比较
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2022.12.282
Y. Guler, E. Kuyucu, A. Kara, Omer Hakyemez, F. Say, A. Bulbul
Osteoarthritis (OA) is a prevalent joint condition that affects areas such as the knee, hip, hand, and spine. In treating mild to moderate cases of OA, treatment options such as intraarticular corticosteroids, viscosupplementation, glucosamine and chondroitin sulfate, PRP, and IL-1Ra are commonly used. This study aimed to compare the effects of IL-1 receptor antagonist (IL-1Ra) and platelet-rich plasma (PRP) on patients with Kellgren-Lawrence (KG) stage 2-3 knee osteoarthritis in terms of Visual Analog Scale (VAS) and Knee injury and osteoarthritis outcome score (KOOS). Ninety patients with KG stage 2-3 knee primary osteoarthritis were divided into two groups, with one group receiving three intraarticular IL-1Ra injections and the other group receiving three PRP injections. VAS and KOOS scores were recorded at the beginning and after six months to evaluate clinical improvement. Both the IL-1Ra and PRP groups showed statistically significant improvement in all scores, including the VAS and KOOS. After six months, the KOOS score in the IL-1Ra group was significantly higher than the PRP group, while the first-year VAS score after treatment in the IL-1Ra group was significantly lower compared to the PRP group. The mean KOOS scores increased from 44.1 to 87.8 and 46.04 to 84.43 at the end of six months in both groups, while the mean VAS scores decreased from 7.27 to 1.02 and 7.29 to 1.71 in the IL-1Ra and PRP groups, respectively. Administering intra-articular IL-1Ra once a week for three weeks can effectively improve function and reduce pain in patients with Kellgren-Lawrence stage 2-3 osteoarthritis. However, more research is necessary to validate the use of IL-1 receptor antagonists in OA treatment.
骨关节炎(OA)是一种常见的关节疾病,影响膝关节、髋关节、手部和脊柱等部位。在治疗轻度至中度OA病例时,常用的治疗方案包括关节内皮质类固醇、补充粘胶、葡萄糖胺和硫酸软骨素、PRP和IL-1Ra。本研究旨在比较IL-1受体拮抗剂(IL-1Ra)和富血小板血浆(PRP)对Kellgren-Lawrence (KG) 2-3期膝关节骨关节炎患者视觉模拟评分(VAS)和膝关节损伤及骨关节炎结局评分(oos)的影响。90例KG期2-3期膝关节原发性骨关节炎患者分为两组,一组接受3次关节内IL-1Ra注射,另一组接受3次PRP注射。分别于治疗开始时和6个月后记录VAS和kos评分,以评估临床改善情况。IL-1Ra组和PRP组在包括VAS和KOOS在内的所有评分上均有统计学意义的改善。6个月后,IL-1Ra组的KOOS评分显著高于PRP组,IL-1Ra组治疗后第一年VAS评分显著低于PRP组。6个月结束时,两组患者的平均KOOS评分分别从44.1上升到87.8和46.04上升到84.43,而IL-1Ra组和PRP组的平均VAS评分分别从7.27下降到1.02和7.29下降到1.71。Kellgren-Lawrence期2-3骨关节炎患者每周1次给予关节内IL-1Ra,连续3周,可有效改善功能,减轻疼痛。然而,需要更多的研究来验证IL-1受体拮抗剂在OA治疗中的应用。
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引用次数: 0
Shared dissociative identity disorder and defector alter personality: controlled human syndrome and the objectification trap phenomenon as a gaslighting form based on dissociative narcissism from the perspective of dissoanalysis theory and dissoanalytic psychohistory 共享解离性身份障碍与叛逃者改变人格:基于解离性自恋的控制性人综合症与煤气灯形式的物化陷阱现象——基于解离性自恋理论与解离性心理史的视角
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.04.053
E. Ozturk
In today's age of global dissociation, it has become necessary to deal with the social and clinical aspects of dissociation, which is a "psychosocial denial experience" in terms of ideational, emotional, relational, behavioral and sensory aspects. In dysfunctional nations experiencing psychosocial denial, democracy unfortunately functions as the majority's freedom to make wrong decisions. The freedom of the majority to make wrong decisions creates “dissociative and misanthropic masses” and causes “universal violence circulation” and despotism to prevail. Dissoanalysis and “Ozturk’s Pervasive and Reversible Dissociative Fusion Theory” define the universal circulation of violence as a reversible “dissociative violence oscillation” associated with trauma, which spreads from individual to society and from society to individual. The submissive mode associated with the experience of connecting to their oppressors and dictators is contagious; it spreads from traumatized and dysfunctional individuals to dissociated and dysfunctional societies, creating fused interpersonal relationships and both conformist and sadomasochistic masses. The dissoanalytic school defines the phenomenon of dissociation, which is most closely related to chronic, complex and cumulative traumatic experiences, which can transform from the individual to the social dimension and from the social dimension to the individual dimension in the face of oppression, and even be experienced simultaneously in the individual and social dimensions, both in relational and psychosociopolitical contexts. Dissoanalytic psychohistory, which continues its development rapidly in parallel with the principles of dissoanalysis and modern psychotraumatology, has far outstripped the stable and dogmatic schools of psychiatry, psychology, and history with its integrative solution-oriented approaches and effective psychosocial prevention strategies towards the phenomenon of trauma-related dissociation and individual and mass obedience cycles against oppression. In this original article, Ozturk defined the phenomenon of “objectification trap”, “controlled human syndrome” and “shared dissociative identity disorder” as the triple pillar of fused bilateral relations dominated by reversible dominative and submissive modes from the perspective of dissoanalysis theory and dissoanalytic psychohistory.
在当今全球分离的时代,有必要处理分离的社会和临床方面,这是一种“心理社会否认经验”,在观念,情感,关系,行为和感官方面。不幸的是,在经历心理排斥的功能失调的国家,民主的作用是让多数人自由做出错误的决定。多数人做出错误决定的自由造成了“分裂和厌恶人类的群众”,导致“普遍暴力循环”和专制盛行。Dissoanalysis和“Ozturk’s Pervasive and Reversible Dissociative Fusion Theory”将暴力的普遍循环定义为与创伤相关的可逆的“Dissociative violence oscillation”,从个人传播到社会,从社会传播到个人。与压迫者和独裁者联系在一起的顺从模式具有传染性;它从受到创伤和功能失调的个人传播到分离和功能失调的社会,造成融合的人际关系以及顺从和受虐的群体。解离学派定义了解离现象,它与慢性的、复杂的、累积的创伤经验关系最为密切,在面对压迫时,可以从个体维度转化为社会维度,从社会维度转化为个体维度,甚至在个体维度和社会维度中同时经历,无论是在关系语境中还是在心理社会政治语境中。精神分析心理史学与精神分析原理和现代精神创伤学同时迅速发展,其综合解决方案导向的方法和有效的社会心理预防策略,远远超过了精神病学、心理学和历史等稳定的教条学派,这些学派针对与创伤相关的分离现象以及个人和群体对压迫的服从循环。在这篇原创文章中,Ozturk从精神分析理论和精神分析心理史的角度,将“客体化陷阱”、“控制性人类综合症”和“共享分离性身份障碍”现象定义为由可逆的支配和服从模式主导的融合双边关系的三重支柱。
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引用次数: 1
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Medicine Science | International Medical Journal
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