Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.10.224
Aysegul Kilici, Şahide Akbulut
The study aims to determine COVID-19 vaccine literacy, attitude and hesitation towards the vaccine, and vaccination status of pregnant women in a rural region. This is a cross-sectional study. It was carried out between June 7 – 7 August 2022. 209 pregnant women were included in the study. The mean score of pregnant women was found to be COVID-19 vaccine literacy 2.5±0.4, attitude 3.1±0.8, and hesitation 7.7±6.6. It was found that 12.4% of the pregnant women had COVID-19 disease in their current pregnancy, and 7.2% of them had COVID-19 disease in the first trimester. It was determined that 34.4% of the pregnancy had a single dose, 30.2% had two doses, and most of them were BioNTech vaccines. Vaccine literacy was determined to be higher in pregnant women who are working, have social security, have a higher income than their expenses and have a master's degree. Those who are married, have social security, and have a female baby have a positive attitude for vaccines. There was a positive significant relationship between COVID-19 vaccine literacy and attitude, and a negative significant relationship between COVID-19 vaccine literacy and hesitancy. It was discovered that COVID-19 vaccine literacy is moderate, vaccination rates are low, and vaccination literacy influences vaccination attitudes and hesitation.
{"title":"COVID-19 vaccination literacy, attitude and hesitation towards vaccination and vaccination status of pregnant women","authors":"Aysegul Kilici, Şahide Akbulut","doi":"10.5455/medscience.2022.10.224","DOIUrl":"https://doi.org/10.5455/medscience.2022.10.224","url":null,"abstract":"The study aims to determine COVID-19 vaccine literacy, attitude and hesitation towards the vaccine, and vaccination status of pregnant women in a rural region. This is a cross-sectional study. It was carried out between June 7 – 7 August 2022. 209 pregnant women were included in the study. The mean score of pregnant women was found to be COVID-19 vaccine literacy 2.5±0.4, attitude 3.1±0.8, and hesitation 7.7±6.6. It was found that 12.4% of the pregnant women had COVID-19 disease in their current pregnancy, and 7.2% of them had COVID-19 disease in the first trimester. It was determined that 34.4% of the pregnancy had a single dose, 30.2% had two doses, and most of them were BioNTech vaccines. Vaccine literacy was determined to be higher in pregnant women who are working, have social security, have a higher income than their expenses and have a master's degree. Those who are married, have social security, and have a female baby have a positive attitude for vaccines. There was a positive significant relationship between COVID-19 vaccine literacy and attitude, and a negative significant relationship between COVID-19 vaccine literacy and hesitancy. It was discovered that COVID-19 vaccine literacy is moderate, vaccination rates are low, and vaccination literacy influences vaccination attitudes and hesitation.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85766124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.11.253
Y. Yuksel, S. Çelik, E. Aslan, M. Tosun, M. Uysal, M. Pektaş
Glioblastoma Multiforme (GBM), which is a common and primary brain tumor in adults, is an important cause of death worldwide as an aggressive and treatment-resistant cancer tumor. In this cell culture study, the apoptotic and anti-proliferative effects of borax and irinotecan at different doses, alone or in combination, were investigated in the YKG1 cell line. Cytotoxic activities were analyzed by MTT method and TUNEL staining after 24th and 48th hours of incubation with borax administered at doses of 1mg and 3mg per ml; irinotecan 50mM and 100mM. Both irinotecan and borax have been shown to induce apoptosis when used alone, and thus cause anti-proliferation. It was determined that these effects were potentiated by the combined application of the agents. In addition, it was determined that this effect in combined applications was more pronounced after 48 hours and at higher doses. In light of the data obtained, the combination of irinotecan with borax to increase the cytotoxic effect of irinotecan, which is used in many different cancer types, can be tried in further prospective studies.
{"title":"Potential cytotoxic effects of borax alone and in combination with irinotecan on YKG1 glioblastoma cell-line","authors":"Y. Yuksel, S. Çelik, E. Aslan, M. Tosun, M. Uysal, M. Pektaş","doi":"10.5455/medscience.2022.11.253","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.253","url":null,"abstract":"Glioblastoma Multiforme (GBM), which is a common and primary brain tumor in adults, is an important cause of death worldwide as an aggressive and treatment-resistant cancer tumor. In this cell culture study, the apoptotic and anti-proliferative effects of borax and irinotecan at different doses, alone or in combination, were investigated in the YKG1 cell line. Cytotoxic activities were analyzed by MTT method and TUNEL staining after 24th and 48th hours of incubation with borax administered at doses of 1mg and 3mg per ml; irinotecan 50mM and 100mM. Both irinotecan and borax have been shown to induce apoptosis when used alone, and thus cause anti-proliferation. It was determined that these effects were potentiated by the combined application of the agents. In addition, it was determined that this effect in combined applications was more pronounced after 48 hours and at higher doses. In light of the data obtained, the combination of irinotecan with borax to increase the cytotoxic effect of irinotecan, which is used in many different cancer types, can be tried in further prospective studies.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91232068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.08.173
Yavuz Yilmaz, Ayla Cicek
Criminal behavior in children emerges as a result of a complex process. If the criminal behavior is repetitive and preventive interventions are not applied, it can also lead to the emergence of criminal behavior in adulthood. In our study, we aimed to compare the parental temperament characteristics of juvenile delinquents with those of non-offending children of similar age and gender. The study group included parents of 69 juvenile delinquents aged between 12 and 15, while the control group consisted of parents of 73 non-offending children of the same age range. Data was collected using a demographic information form prepared by researchers and the TEMPS-A (Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionnaire) Temperament Scale. The study group included 37 fathers and 32 mothers, while the control group included 40 fathers and 33 mothers. Parents in the study group had less education than those in the control group, and psychopathology was more common. The study group's parents experienced more legal issues on average. In comparison to the control group, fathers in the study group scored higher for cyclothymic temperament, hyperthymic temperament, and irritable temperament. Compared to the control group, mothers in the study group scored higher on all temperamental variables. The fathers' assessments of their depressive and anxious temperaments did not differ significantly. Fathers in the study group scored higher on the cyclothymic, hyperthymic, and irritable temperament scales. There was a considerable difference in the prevailing temperament type between the groups. Moms in the research group had significantly higher temperament scores than those in the control group.
{"title":"Parental temperament characteristics of juvenile delinquents","authors":"Yavuz Yilmaz, Ayla Cicek","doi":"10.5455/medscience.2023.08.173","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.173","url":null,"abstract":"Criminal behavior in children emerges as a result of a complex process. If the criminal behavior is repetitive and preventive interventions are not applied, it can also lead to the emergence of criminal behavior in adulthood. In our study, we aimed to compare the parental temperament characteristics of juvenile delinquents with those of non-offending children of similar age and gender. The study group included parents of 69 juvenile delinquents aged between 12 and 15, while the control group consisted of parents of 73 non-offending children of the same age range. Data was collected using a demographic information form prepared by researchers and the TEMPS-A (Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionnaire) Temperament Scale. The study group included 37 fathers and 32 mothers, while the control group included 40 fathers and 33 mothers. Parents in the study group had less education than those in the control group, and psychopathology was more common. The study group's parents experienced more legal issues on average. In comparison to the control group, fathers in the study group scored higher for cyclothymic temperament, hyperthymic temperament, and irritable temperament. Compared to the control group, mothers in the study group scored higher on all temperamental variables. The fathers' assessments of their depressive and anxious temperaments did not differ significantly. Fathers in the study group scored higher on the cyclothymic, hyperthymic, and irritable temperament scales. There was a considerable difference in the prevailing temperament type between the groups. Moms in the research group had significantly higher temperament scores than those in the control group.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135319111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.10.203
Ibrahim Etli, Hasan May, Engin Cicek, Cihan Celik, Abdullahi Mohamed
The plantar muscle is fusiform, attaching to the calcaneus, starting behind the knee. Plantaris muscle formation has been reported in humans at a rate approaching 90%. It is frequently preferred for tendon grafting and tendon transfer in hand surgery and Achilles tendon injuries. In this study, our goal is to investigate the frequency of the presence of the plantar muscle in the Somali population. We retrospectively analyzed 607 knee MRI scans performed at Recep Tayyip Erdoğan Training and Research Hospital in Mogadishu between January 2019 and March 2022. The clinical and demographic characteristics of the patients were recorded. Patients with muscle trauma and previous surgery involving muscles, proximal tibia fracture surgery, and soft tissue tumors were dropped out of the study. 469 (77.3%) of these patients were male and 138 (22.7%) were female.182 (72%) of the male patients with right MRI saw plantaris while 68 (28%) did not. While plantaris was seen in 183 (83.5%) of the male patients who underwent left-sided MRI, plantaris was not seen in 30 (16.5%). Plantaris was seen in 62 (79.5%) of the female patients who had right-sided MRI, while plantaris was not seen in 16 (20.5%). Left plantar was present in 55 (91.7%) and absent in 5 (8.3%) female patients who underwent left-sided MRI. Since the plantaris muscle is used as a tendon graft, pre-op evaluation of its presence is important in terms of surgery and can change the surgical procedure. The presence of the plantar tendon can be revealed by using knee MRI in the Somali population living in the African continent.
{"title":"What is the prevalence of plantar tendon used as tendon graft in the Somali population?","authors":"Ibrahim Etli, Hasan May, Engin Cicek, Cihan Celik, Abdullahi Mohamed","doi":"10.5455/medscience.2023.10.203","DOIUrl":"https://doi.org/10.5455/medscience.2023.10.203","url":null,"abstract":"The plantar muscle is fusiform, attaching to the calcaneus, starting behind the knee. Plantaris muscle formation has been reported in humans at a rate approaching 90%. It is frequently preferred for tendon grafting and tendon transfer in hand surgery and Achilles tendon injuries. In this study, our goal is to investigate the frequency of the presence of the plantar muscle in the Somali population. We retrospectively analyzed 607 knee MRI scans performed at Recep Tayyip Erdoğan Training and Research Hospital in Mogadishu between January 2019 and March 2022. The clinical and demographic characteristics of the patients were recorded. Patients with muscle trauma and previous surgery involving muscles, proximal tibia fracture surgery, and soft tissue tumors were dropped out of the study. 469 (77.3%) of these patients were male and 138 (22.7%) were female.182 (72%) of the male patients with right MRI saw plantaris while 68 (28%) did not. While plantaris was seen in 183 (83.5%) of the male patients who underwent left-sided MRI, plantaris was not seen in 30 (16.5%). Plantaris was seen in 62 (79.5%) of the female patients who had right-sided MRI, while plantaris was not seen in 16 (20.5%). Left plantar was present in 55 (91.7%) and absent in 5 (8.3%) female patients who underwent left-sided MRI. Since the plantaris muscle is used as a tendon graft, pre-op evaluation of its presence is important in terms of surgery and can change the surgical procedure. The presence of the plantar tendon can be revealed by using knee MRI in the Somali population living in the African continent.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.08.160
Zekiye Kirmaci, Nevin Ergun
The center of the body is the trunk. For distal extremity movements, balance, and functional tasks, proximal trunk control is crucial. The aim of the study is to examine the relationship of trunk control with balance, upper extremity and lower extremity functions in stroke patients. Thirty-six stroke patients were included in this cross-sectional descriptive study. Trunk control was assessed using the Trunk Impairment Scale (TIS), Berg Balance Scale (BBS) was used for balance evaluation, Fugl-Meyer Lower Extremity Scale (FML) was used for lower extremity function evaluation, Fugl-Meyer Upper Extremity Scale (FMU) was used for upper extremity function evaluation. The mean age of the included stroke patients was 62±11 years. There was a moderate negative correlation between TIS and BBS (r=-0.610, p<0.01). A moderate negative correlation was found between TIS and FML (r=-0.520, p=0.001). A low negative correlation was found between TIS and FMU (r=-0.372, p=0.025). Trunk control affects balance, lower extremity and upper extremity function. In the treatment of stroke patients, exercise approaches for trunk control should be added to rehabilitation programs in addition to basic neurophysiological approaches.
{"title":"The relationship of trunk control with balance, upper extremity and lower extremity functions in stroke patients","authors":"Zekiye Kirmaci, Nevin Ergun","doi":"10.5455/medscience.2023.08.160","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.160","url":null,"abstract":"The center of the body is the trunk. For distal extremity movements, balance, and functional tasks, proximal trunk control is crucial. The aim of the study is to examine the relationship of trunk control with balance, upper extremity and lower extremity functions in stroke patients. Thirty-six stroke patients were included in this cross-sectional descriptive study. Trunk control was assessed using the Trunk Impairment Scale (TIS), Berg Balance Scale (BBS) was used for balance evaluation, Fugl-Meyer Lower Extremity Scale (FML) was used for lower extremity function evaluation, Fugl-Meyer Upper Extremity Scale (FMU) was used for upper extremity function evaluation. The mean age of the included stroke patients was 62±11 years. There was a moderate negative correlation between TIS and BBS (r=-0.610, p<0.01). A moderate negative correlation was found between TIS and FML (r=-0.520, p=0.001). A low negative correlation was found between TIS and FMU (r=-0.372, p=0.025). Trunk control affects balance, lower extremity and upper extremity function. In the treatment of stroke patients, exercise approaches for trunk control should be added to rehabilitation programs in addition to basic neurophysiological approaches.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136205091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.05.060
M. Kıran, N. Sungu, Hayriye Dogan, Arslan Ardicoglu, Fazli Erdogan, B. Gumuskaya
Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists for HIF-2α. This study encompassed 239 cases, where tissue microarray (TMA) sections were exposed to HIF-1α, HIF-2α, and HAF antibodies. Staining intensity and tumor cell percentage determined scores for HIF-1α, HIF-2α, and HAF, with median histoscore establishing "high" or "low" cutoffs. Among the cases, 64.9% (155 cases) were negative for HIF-1α, 17.6% (42 cases) displayed low, and another 17.6% (42 cases) showed strong HIF-1α expression. HIF-1α expression correlated significantly with histological type and World Health Organization/International Society of Urological Pathology (WHO/ISUP) nuclear grade. Regarding HIF-2α, 15.5% (37 cases) were negative, 23.4% (56 cases) exhibited low, and 61.1% (146 cases) displayed high expression, with larger tumor size in the high HIF-2α group. Among 239 cases, 41.4% (99 cases) were negative for HAF, 36.8% (88 cases) showed low, and 21.8% (52 cases) displayed high HAF scores. HAF expression correlated with WHO/ISUP nuclear grade and metastasis presence. Notably, HIF-2α staining intensity directly correlated with increased HAF intensity (rho=0.146; p=0.024), while HIF-1α intensity decrease corresponded with heightened HAF intensity, showing a statistically significant negative correlation (rho=-0.180; p=0.005). In this rare examination of tumor tissue, a reverse connection between HIF-1α and HAF expression was uncovered, while a linear link emerged between HIF-2α and HAF expression. Overall, this study established that HIF-1α, HIF-2α, and HAF expression are associated with an unfavorable prognosis.
{"title":"Hypoxia inducible factors and hypoxia associated factor expression profiles and prognostic significance in renal cell carcinomas","authors":"M. Kıran, N. Sungu, Hayriye Dogan, Arslan Ardicoglu, Fazli Erdogan, B. Gumuskaya","doi":"10.5455/medscience.2023.05.060","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.060","url":null,"abstract":"Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists for HIF-2α. This study encompassed 239 cases, where tissue microarray (TMA) sections were exposed to HIF-1α, HIF-2α, and HAF antibodies. Staining intensity and tumor cell percentage determined scores for HIF-1α, HIF-2α, and HAF, with median histoscore establishing \"high\" or \"low\" cutoffs. Among the cases, 64.9% (155 cases) were negative for HIF-1α, 17.6% (42 cases) displayed low, and another 17.6% (42 cases) showed strong HIF-1α expression. HIF-1α expression correlated significantly with histological type and World Health Organization/International Society of Urological Pathology (WHO/ISUP) nuclear grade. Regarding HIF-2α, 15.5% (37 cases) were negative, 23.4% (56 cases) exhibited low, and 61.1% (146 cases) displayed high expression, with larger tumor size in the high HIF-2α group. Among 239 cases, 41.4% (99 cases) were negative for HAF, 36.8% (88 cases) showed low, and 21.8% (52 cases) displayed high HAF scores. HAF expression correlated with WHO/ISUP nuclear grade and metastasis presence. Notably, HIF-2α staining intensity directly correlated with increased HAF intensity (rho=0.146; p=0.024), while HIF-1α intensity decrease corresponded with heightened HAF intensity, showing a statistically significant negative correlation (rho=-0.180; p=0.005). In this rare examination of tumor tissue, a reverse connection between HIF-1α and HAF expression was uncovered, while a linear link emerged between HIF-2α and HAF expression. Overall, this study established that HIF-1α, HIF-2α, and HAF expression are associated with an unfavorable prognosis.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88836381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.06.092
Mustafa Karademir, G. Altun, Dilay Karademir
Although NMBAs (Neuro Muscular Blocking Agents) have been used for a long time, postoperative residual curarization is still a significant problem. Nowadays, an agent named Sugammadex is used for the reversal of curarization. It has been presented as a safer agent than its predecessor, neostigmine. The main purpose of this study is to investigate the effects of Sugammadex on rat thoracic aorta and enlighten the mechanism of action and potential benefits in surgical operations with general anesthesia. Twenty Wistar albino rats were used for the experiments. Thoracic aorta segments have been removed and mounted to the organ bath. Contraction and relaxation responses were presented as a percentage of phenylephrine (3x10-5 M) contraction. After recording contractile responses of Sugammadex (10-8-10-4 M), relaxation responses of Sugammadex (10-8-10-4 M) have been recorded both in the presence and absence of L-NAME (3x10-5 M) (Potent Nitric Oxide Sentase Inhibitor). Finally, relaxation responses of sugammadex-rocuronium have been recorded. Sugammadex caused slightly noticeable and concentration-dependent contraction on isolated thoracic aorta strips. Sugammadex also caused potent and concentration-dependent relaxation on isolated rat thoracic aorta. The relaxation response caused by Sugammadex has been diminished significantly in the presence of L-NAME. Administration of rocuronium with Sugammadex did cause neither relaxation nor any additional contractile effect on isolated rat thoracic aorta strips. Sugammadex is a promising agent in reversing rocuronium-induced neuromuscular block. Although the adverse effects of this agent are not studied in detail, it seems Sugammadex is safer than neostigmine. The side effects of anesthetic agents are one of the main problems of surgical procedures, including neurosurgery, gynecology, and obstetrics. Especially acute hypotension may be fatal in neurosurgery and gynecological operations. Sugammadex should be used carefully in adjusted and individualized doses to avoid hypotension-related adverse effects.
{"title":"Evaluation of the vasorelaxant effect of Sugammadex on the arterial smooth muscle in rats","authors":"Mustafa Karademir, G. Altun, Dilay Karademir","doi":"10.5455/medscience.2023.06.092","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.092","url":null,"abstract":"Although NMBAs (Neuro Muscular Blocking Agents) have been used for a long time, postoperative residual curarization is still a significant problem. Nowadays, an agent named Sugammadex is used for the reversal of curarization. It has been presented as a safer agent than its predecessor, neostigmine. The main purpose of this study is to investigate the effects of Sugammadex on rat thoracic aorta and enlighten the mechanism of action and potential benefits in surgical operations with general anesthesia. Twenty Wistar albino rats were used for the experiments. Thoracic aorta segments have been removed and mounted to the organ bath. Contraction and relaxation responses were presented as a percentage of phenylephrine (3x10-5 M) contraction. After recording contractile responses of Sugammadex (10-8-10-4 M), relaxation responses of Sugammadex (10-8-10-4 M) have been recorded both in the presence and absence of L-NAME (3x10-5 M) (Potent Nitric Oxide Sentase Inhibitor). Finally, relaxation responses of sugammadex-rocuronium have been recorded. Sugammadex caused slightly noticeable and concentration-dependent contraction on isolated thoracic aorta strips. Sugammadex also caused potent and concentration-dependent relaxation on isolated rat thoracic aorta. The relaxation response caused by Sugammadex has been diminished significantly in the presence of L-NAME. Administration of rocuronium with Sugammadex did cause neither relaxation nor any additional contractile effect on isolated rat thoracic aorta strips. Sugammadex is a promising agent in reversing rocuronium-induced neuromuscular block. Although the adverse effects of this agent are not studied in detail, it seems Sugammadex is safer than neostigmine. The side effects of anesthetic agents are one of the main problems of surgical procedures, including neurosurgery, gynecology, and obstetrics. Especially acute hypotension may be fatal in neurosurgery and gynecological operations. Sugammadex should be used carefully in adjusted and individualized doses to avoid hypotension-related adverse effects.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"464 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88892079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.12.279
Z. Agaç, S. Karaahmetoğlu, T. Akyol
Early differentiation of cases with severe acute cholangitis is important for optimal treatment. In this study, it was aimed to elucidate the prognosis with complete blood count parameters among patients with acute cholangitis. Clinical and laboratory findings of 200 patients with acute cholangitis at Ankara City Hospital between February 2019 and October 2019 were retrospectively analyzed. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, red cell distribution width and mean platelet volume levels were recorded from blood analysis at the time of admission. According to Tokyo guidelines, patients were divided into 3 groups as mild, moderate and severe acute cholangitis. In order to evaluate the prognosis, the length of hospital stay, the status of hospitalization in the medical intensive care unit and blood culture growth were investigated with hematological parameters. Of the 200 patients, 109 (54.5%) were male and 91 (45.5%) were female. According to Tokyo criteria, 17 patients’ status was evaluated as severe, 70 as moderate and 113 as mild acute cholangitis. The area under the receiver operating characteristics curve for neutrophil-lymphocyte ratio measurements was statistically significant in distinguishing the mild vs moderate disease (AUC=0.694; 95% Confidence Interval (CI):0.586-0.802 and p=0.008), with a diagnostic accuracy rate of 59.5%. The diagnostic accuracy rate of red cell distribution width (AUC=0.603; 95% CI: 0.523-0.683 and p=0.013) was 61.5% and the diagnostic accuracy rate of mean platelet volume (AUC=0.582 95% CI: 0.502-0.662 and p=0.047) was 57.5% achieving a statistical significance. Neutrophil-lymphocyte ratio, red cell distribution width and mean platelet volume analysis is routinely obtained from complete blood count almost in every patient. These are inexpensive and easily accessible diagnostic markers and thus, might be useful in the differentiation of mild and severe acute cholangitis patients and their prognosis.
{"title":"Evaluation of prognosis of acute colangitis patients via hematological parameters","authors":"Z. Agaç, S. Karaahmetoğlu, T. Akyol","doi":"10.5455/medscience.2022.12.279","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.279","url":null,"abstract":"Early differentiation of cases with severe acute cholangitis is important for optimal treatment. In this study, it was aimed to elucidate the prognosis with complete blood count parameters among patients with acute cholangitis. Clinical and laboratory findings of 200 patients with acute cholangitis at Ankara City Hospital between February 2019 and October 2019 were retrospectively analyzed. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, red cell distribution width and mean platelet volume levels were recorded from blood analysis at the time of admission. According to Tokyo guidelines, patients were divided into 3 groups as mild, moderate and severe acute cholangitis. In order to evaluate the prognosis, the length of hospital stay, the status of hospitalization in the medical intensive care unit and blood culture growth were investigated with hematological parameters. Of the 200 patients, 109 (54.5%) were male and 91 (45.5%) were female. According to Tokyo criteria, 17 patients’ status was evaluated as severe, 70 as moderate and 113 as mild acute cholangitis. The area under the receiver operating characteristics curve for neutrophil-lymphocyte ratio measurements was statistically significant in distinguishing the mild vs moderate disease (AUC=0.694; 95% Confidence Interval (CI):0.586-0.802 and p=0.008), with a diagnostic accuracy rate of 59.5%. The diagnostic accuracy rate of red cell distribution width (AUC=0.603; 95% CI: 0.523-0.683 and p=0.013) was 61.5% and the diagnostic accuracy rate of mean platelet volume (AUC=0.582 95% CI: 0.502-0.662 and p=0.047) was 57.5% achieving a statistical significance. Neutrophil-lymphocyte ratio, red cell distribution width and mean platelet volume analysis is routinely obtained from complete blood count almost in every patient. These are inexpensive and easily accessible diagnostic markers and thus, might be useful in the differentiation of mild and severe acute cholangitis patients and their prognosis.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82112649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.12.282
Y. Guler, E. Kuyucu, A. Kara, Omer Hakyemez, F. Say, A. Bulbul
Osteoarthritis (OA) is a prevalent joint condition that affects areas such as the knee, hip, hand, and spine. In treating mild to moderate cases of OA, treatment options such as intraarticular corticosteroids, viscosupplementation, glucosamine and chondroitin sulfate, PRP, and IL-1Ra are commonly used. This study aimed to compare the effects of IL-1 receptor antagonist (IL-1Ra) and platelet-rich plasma (PRP) on patients with Kellgren-Lawrence (KG) stage 2-3 knee osteoarthritis in terms of Visual Analog Scale (VAS) and Knee injury and osteoarthritis outcome score (KOOS). Ninety patients with KG stage 2-3 knee primary osteoarthritis were divided into two groups, with one group receiving three intraarticular IL-1Ra injections and the other group receiving three PRP injections. VAS and KOOS scores were recorded at the beginning and after six months to evaluate clinical improvement. Both the IL-1Ra and PRP groups showed statistically significant improvement in all scores, including the VAS and KOOS. After six months, the KOOS score in the IL-1Ra group was significantly higher than the PRP group, while the first-year VAS score after treatment in the IL-1Ra group was significantly lower compared to the PRP group. The mean KOOS scores increased from 44.1 to 87.8 and 46.04 to 84.43 at the end of six months in both groups, while the mean VAS scores decreased from 7.27 to 1.02 and 7.29 to 1.71 in the IL-1Ra and PRP groups, respectively. Administering intra-articular IL-1Ra once a week for three weeks can effectively improve function and reduce pain in patients with Kellgren-Lawrence stage 2-3 osteoarthritis. However, more research is necessary to validate the use of IL-1 receptor antagonists in OA treatment.
{"title":"Short-term comparison of intraarticular administration of IL-1 receptor antagonist and platelet-rich plasma for osteoarthritis treatment","authors":"Y. Guler, E. Kuyucu, A. Kara, Omer Hakyemez, F. Say, A. Bulbul","doi":"10.5455/medscience.2022.12.282","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.282","url":null,"abstract":"Osteoarthritis (OA) is a prevalent joint condition that affects areas such as the knee, hip, hand, and spine. In treating mild to moderate cases of OA, treatment options such as intraarticular corticosteroids, viscosupplementation, glucosamine and chondroitin sulfate, PRP, and IL-1Ra are commonly used. This study aimed to compare the effects of IL-1 receptor antagonist (IL-1Ra) and platelet-rich plasma (PRP) on patients with Kellgren-Lawrence (KG) stage 2-3 knee osteoarthritis in terms of Visual Analog Scale (VAS) and Knee injury and osteoarthritis outcome score (KOOS). Ninety patients with KG stage 2-3 knee primary osteoarthritis were divided into two groups, with one group receiving three intraarticular IL-1Ra injections and the other group receiving three PRP injections. VAS and KOOS scores were recorded at the beginning and after six months to evaluate clinical improvement. Both the IL-1Ra and PRP groups showed statistically significant improvement in all scores, including the VAS and KOOS. After six months, the KOOS score in the IL-1Ra group was significantly higher than the PRP group, while the first-year VAS score after treatment in the IL-1Ra group was significantly lower compared to the PRP group. The mean KOOS scores increased from 44.1 to 87.8 and 46.04 to 84.43 at the end of six months in both groups, while the mean VAS scores decreased from 7.27 to 1.02 and 7.29 to 1.71 in the IL-1Ra and PRP groups, respectively. Administering intra-articular IL-1Ra once a week for three weeks can effectively improve function and reduce pain in patients with Kellgren-Lawrence stage 2-3 osteoarthritis. However, more research is necessary to validate the use of IL-1 receptor antagonists in OA treatment.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79917147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.04.053
E. Ozturk
In today's age of global dissociation, it has become necessary to deal with the social and clinical aspects of dissociation, which is a "psychosocial denial experience" in terms of ideational, emotional, relational, behavioral and sensory aspects. In dysfunctional nations experiencing psychosocial denial, democracy unfortunately functions as the majority's freedom to make wrong decisions. The freedom of the majority to make wrong decisions creates “dissociative and misanthropic masses” and causes “universal violence circulation” and despotism to prevail. Dissoanalysis and “Ozturk’s Pervasive and Reversible Dissociative Fusion Theory” define the universal circulation of violence as a reversible “dissociative violence oscillation” associated with trauma, which spreads from individual to society and from society to individual. The submissive mode associated with the experience of connecting to their oppressors and dictators is contagious; it spreads from traumatized and dysfunctional individuals to dissociated and dysfunctional societies, creating fused interpersonal relationships and both conformist and sadomasochistic masses. The dissoanalytic school defines the phenomenon of dissociation, which is most closely related to chronic, complex and cumulative traumatic experiences, which can transform from the individual to the social dimension and from the social dimension to the individual dimension in the face of oppression, and even be experienced simultaneously in the individual and social dimensions, both in relational and psychosociopolitical contexts. Dissoanalytic psychohistory, which continues its development rapidly in parallel with the principles of dissoanalysis and modern psychotraumatology, has far outstripped the stable and dogmatic schools of psychiatry, psychology, and history with its integrative solution-oriented approaches and effective psychosocial prevention strategies towards the phenomenon of trauma-related dissociation and individual and mass obedience cycles against oppression. In this original article, Ozturk defined the phenomenon of “objectification trap”, “controlled human syndrome” and “shared dissociative identity disorder” as the triple pillar of fused bilateral relations dominated by reversible dominative and submissive modes from the perspective of dissoanalysis theory and dissoanalytic psychohistory.
在当今全球分离的时代，有必要处理分离的社会和临床方面，这是一种“心理社会否认经验”，在观念，情感，关系，行为和感官方面。不幸的是，在经历心理排斥的功能失调的国家，民主的作用是让多数人自由做出错误的决定。多数人做出错误决定的自由造成了“分裂和厌恶人类的群众”，导致“普遍暴力循环”和专制盛行。Dissoanalysis和“Ozturk’s Pervasive and Reversible Dissociative Fusion Theory”将暴力的普遍循环定义为与创伤相关的可逆的“Dissociative violence oscillation”，从个人传播到社会，从社会传播到个人。与压迫者和独裁者联系在一起的顺从模式具有传染性;它从受到创伤和功能失调的个人传播到分离和功能失调的社会，造成融合的人际关系以及顺从和受虐的群体。解离学派定义了解离现象，它与慢性的、复杂的、累积的创伤经验关系最为密切，在面对压迫时，可以从个体维度转化为社会维度，从社会维度转化为个体维度，甚至在个体维度和社会维度中同时经历，无论是在关系语境中还是在心理社会政治语境中。精神分析心理史学与精神分析原理和现代精神创伤学同时迅速发展，其综合解决方案导向的方法和有效的社会心理预防策略，远远超过了精神病学、心理学和历史等稳定的教条学派，这些学派针对与创伤相关的分离现象以及个人和群体对压迫的服从循环。在这篇原创文章中，Ozturk从精神分析理论和精神分析心理史的角度，将“客体化陷阱”、“控制性人类综合症”和“共享分离性身份障碍”现象定义为由可逆的支配和服从模式主导的融合双边关系的三重支柱。
{"title":"Shared dissociative identity disorder and defector alter personality: controlled human syndrome and the objectification trap phenomenon as a gaslighting form based on dissociative narcissism from the perspective of dissoanalysis theory and dissoanalytic psychohistory","authors":"E. Ozturk","doi":"10.5455/medscience.2023.04.053","DOIUrl":"https://doi.org/10.5455/medscience.2023.04.053","url":null,"abstract":"In today's age of global dissociation, it has become necessary to deal with the social and clinical aspects of dissociation, which is a \"psychosocial denial experience\" in terms of ideational, emotional, relational, behavioral and sensory aspects. In dysfunctional nations experiencing psychosocial denial, democracy unfortunately functions as the majority's freedom to make wrong decisions. The freedom of the majority to make wrong decisions creates “dissociative and misanthropic masses” and causes “universal violence circulation” and despotism to prevail. Dissoanalysis and “Ozturk’s Pervasive and Reversible Dissociative Fusion Theory” define the universal circulation of violence as a reversible “dissociative violence oscillation” associated with trauma, which spreads from individual to society and from society to individual. The submissive mode associated with the experience of connecting to their oppressors and dictators is contagious; it spreads from traumatized and dysfunctional individuals to dissociated and dysfunctional societies, creating fused interpersonal relationships and both conformist and sadomasochistic masses. The dissoanalytic school defines the phenomenon of dissociation, which is most closely related to chronic, complex and cumulative traumatic experiences, which can transform from the individual to the social dimension and from the social dimension to the individual dimension in the face of oppression, and even be experienced simultaneously in the individual and social dimensions, both in relational and psychosociopolitical contexts. Dissoanalytic psychohistory, which continues its development rapidly in parallel with the principles of dissoanalysis and modern psychotraumatology, has far outstripped the stable and dogmatic schools of psychiatry, psychology, and history with its integrative solution-oriented approaches and effective psychosocial prevention strategies towards the phenomenon of trauma-related dissociation and individual and mass obedience cycles against oppression. In this original article, Ozturk defined the phenomenon of “objectification trap”, “controlled human syndrome” and “shared dissociative identity disorder” as the triple pillar of fused bilateral relations dominated by reversible dominative and submissive modes from the perspective of dissoanalysis theory and dissoanalytic psychohistory.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82721569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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