Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.06.092
Mustafa Karademir, G. Altun, Dilay Karademir
Although NMBAs (Neuro Muscular Blocking Agents) have been used for a long time, postoperative residual curarization is still a significant problem. Nowadays, an agent named Sugammadex is used for the reversal of curarization. It has been presented as a safer agent than its predecessor, neostigmine. The main purpose of this study is to investigate the effects of Sugammadex on rat thoracic aorta and enlighten the mechanism of action and potential benefits in surgical operations with general anesthesia. Twenty Wistar albino rats were used for the experiments. Thoracic aorta segments have been removed and mounted to the organ bath. Contraction and relaxation responses were presented as a percentage of phenylephrine (3x10-5 M) contraction. After recording contractile responses of Sugammadex (10-8-10-4 M), relaxation responses of Sugammadex (10-8-10-4 M) have been recorded both in the presence and absence of L-NAME (3x10-5 M) (Potent Nitric Oxide Sentase Inhibitor). Finally, relaxation responses of sugammadex-rocuronium have been recorded. Sugammadex caused slightly noticeable and concentration-dependent contraction on isolated thoracic aorta strips. Sugammadex also caused potent and concentration-dependent relaxation on isolated rat thoracic aorta. The relaxation response caused by Sugammadex has been diminished significantly in the presence of L-NAME. Administration of rocuronium with Sugammadex did cause neither relaxation nor any additional contractile effect on isolated rat thoracic aorta strips. Sugammadex is a promising agent in reversing rocuronium-induced neuromuscular block. Although the adverse effects of this agent are not studied in detail, it seems Sugammadex is safer than neostigmine. The side effects of anesthetic agents are one of the main problems of surgical procedures, including neurosurgery, gynecology, and obstetrics. Especially acute hypotension may be fatal in neurosurgery and gynecological operations. Sugammadex should be used carefully in adjusted and individualized doses to avoid hypotension-related adverse effects.
{"title":"Evaluation of the vasorelaxant effect of Sugammadex on the arterial smooth muscle in rats","authors":"Mustafa Karademir, G. Altun, Dilay Karademir","doi":"10.5455/medscience.2023.06.092","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.092","url":null,"abstract":"Although NMBAs (Neuro Muscular Blocking Agents) have been used for a long time, postoperative residual curarization is still a significant problem. Nowadays, an agent named Sugammadex is used for the reversal of curarization. It has been presented as a safer agent than its predecessor, neostigmine. The main purpose of this study is to investigate the effects of Sugammadex on rat thoracic aorta and enlighten the mechanism of action and potential benefits in surgical operations with general anesthesia. Twenty Wistar albino rats were used for the experiments. Thoracic aorta segments have been removed and mounted to the organ bath. Contraction and relaxation responses were presented as a percentage of phenylephrine (3x10-5 M) contraction. After recording contractile responses of Sugammadex (10-8-10-4 M), relaxation responses of Sugammadex (10-8-10-4 M) have been recorded both in the presence and absence of L-NAME (3x10-5 M) (Potent Nitric Oxide Sentase Inhibitor). Finally, relaxation responses of sugammadex-rocuronium have been recorded. Sugammadex caused slightly noticeable and concentration-dependent contraction on isolated thoracic aorta strips. Sugammadex also caused potent and concentration-dependent relaxation on isolated rat thoracic aorta. The relaxation response caused by Sugammadex has been diminished significantly in the presence of L-NAME. Administration of rocuronium with Sugammadex did cause neither relaxation nor any additional contractile effect on isolated rat thoracic aorta strips. Sugammadex is a promising agent in reversing rocuronium-induced neuromuscular block. Although the adverse effects of this agent are not studied in detail, it seems Sugammadex is safer than neostigmine. The side effects of anesthetic agents are one of the main problems of surgical procedures, including neurosurgery, gynecology, and obstetrics. Especially acute hypotension may be fatal in neurosurgery and gynecological operations. Sugammadex should be used carefully in adjusted and individualized doses to avoid hypotension-related adverse effects.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"464 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88892079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.05.060
M. Kıran, N. Sungu, Hayriye Dogan, Arslan Ardicoglu, Fazli Erdogan, B. Gumuskaya
Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists for HIF-2α. This study encompassed 239 cases, where tissue microarray (TMA) sections were exposed to HIF-1α, HIF-2α, and HAF antibodies. Staining intensity and tumor cell percentage determined scores for HIF-1α, HIF-2α, and HAF, with median histoscore establishing "high" or "low" cutoffs. Among the cases, 64.9% (155 cases) were negative for HIF-1α, 17.6% (42 cases) displayed low, and another 17.6% (42 cases) showed strong HIF-1α expression. HIF-1α expression correlated significantly with histological type and World Health Organization/International Society of Urological Pathology (WHO/ISUP) nuclear grade. Regarding HIF-2α, 15.5% (37 cases) were negative, 23.4% (56 cases) exhibited low, and 61.1% (146 cases) displayed high expression, with larger tumor size in the high HIF-2α group. Among 239 cases, 41.4% (99 cases) were negative for HAF, 36.8% (88 cases) showed low, and 21.8% (52 cases) displayed high HAF scores. HAF expression correlated with WHO/ISUP nuclear grade and metastasis presence. Notably, HIF-2α staining intensity directly correlated with increased HAF intensity (rho=0.146; p=0.024), while HIF-1α intensity decrease corresponded with heightened HAF intensity, showing a statistically significant negative correlation (rho=-0.180; p=0.005). In this rare examination of tumor tissue, a reverse connection between HIF-1α and HAF expression was uncovered, while a linear link emerged between HIF-2α and HAF expression. Overall, this study established that HIF-1α, HIF-2α, and HAF expression are associated with an unfavorable prognosis.
{"title":"Hypoxia inducible factors and hypoxia associated factor expression profiles and prognostic significance in renal cell carcinomas","authors":"M. Kıran, N. Sungu, Hayriye Dogan, Arslan Ardicoglu, Fazli Erdogan, B. Gumuskaya","doi":"10.5455/medscience.2023.05.060","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.060","url":null,"abstract":"Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists for HIF-2α. This study encompassed 239 cases, where tissue microarray (TMA) sections were exposed to HIF-1α, HIF-2α, and HAF antibodies. Staining intensity and tumor cell percentage determined scores for HIF-1α, HIF-2α, and HAF, with median histoscore establishing \"high\" or \"low\" cutoffs. Among the cases, 64.9% (155 cases) were negative for HIF-1α, 17.6% (42 cases) displayed low, and another 17.6% (42 cases) showed strong HIF-1α expression. HIF-1α expression correlated significantly with histological type and World Health Organization/International Society of Urological Pathology (WHO/ISUP) nuclear grade. Regarding HIF-2α, 15.5% (37 cases) were negative, 23.4% (56 cases) exhibited low, and 61.1% (146 cases) displayed high expression, with larger tumor size in the high HIF-2α group. Among 239 cases, 41.4% (99 cases) were negative for HAF, 36.8% (88 cases) showed low, and 21.8% (52 cases) displayed high HAF scores. HAF expression correlated with WHO/ISUP nuclear grade and metastasis presence. Notably, HIF-2α staining intensity directly correlated with increased HAF intensity (rho=0.146; p=0.024), while HIF-1α intensity decrease corresponded with heightened HAF intensity, showing a statistically significant negative correlation (rho=-0.180; p=0.005). In this rare examination of tumor tissue, a reverse connection between HIF-1α and HAF expression was uncovered, while a linear link emerged between HIF-2α and HAF expression. Overall, this study established that HIF-1α, HIF-2α, and HAF expression are associated with an unfavorable prognosis.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88836381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.11.234
Ş. Savrun, A. Savrun
The World Health Organization (WHO) stated that the elderly population constituted 12% of the population of people over 60 years old in 2015. In the coming years, by 2030, 1 out of 6 people in the world will be 60 years or older, and this ratio will increase to 22% in 2050. In addition, it is estimated that the proportion of the elderly population will be 11.0% in 2025, 12.9% in 2030, 16.3% in 2040, 22.6% in 2060 and 25.6% in 2080. The number of admissions to the emergency services of geriatric patients, the hospital treatment process, and even the mortality and morbidity rates increase in elderly patients. In this direction, it was aimed to retrospectively analyze the data of patients over 65 who applied to a tertiary hospital emergency department and determine the factors affecting the mortality of geriatric patients. The presented study is a cross-sectional and retrospective study. All patients over the age of 65 who applied to the emergency department of Ordu University Medical Faculty Training and Research Hospital between 01 July 2022 and 31 2022 were retrospectively analyzed. Demographic features of the cases, the way they applied to the emergency room (112 Emergency Service Ambulance, others: with their own vehicle, by taxi, etc.), the last diagnosis in the emergency department (neurological, cardiovascular, respiratory, metabolic, trauma and others), treatment methods (outpatient, inpatient, intensive care), their motility and the relationship of these data with each other were examined. Between the specified dates, a total of 28459 patients over the age of 18 were admitted to the emergency department. It was determined that 10.16% (n=2894) of these patients consisted of patients over 65 years of age. The relationship between the treatment modalities and mortality according to the way the patients came to the hospital was found to be statistically significant (p<0.005). The relationship between hospitalization, treatment modalities and mortality was statistically significant according to the clinical diagnosis of the cases (p<0.005). In the presented study, it was determined that the mortality of patients who applied to the emergency department due to metabolic problems and who used the ambulance system as a referral tool was high. In fact, the prognosis of geriatric patients who apply to the emergency department for any reason, especially by using the emergency ambulance system, is worse than those who do not use the emergency ambulance system. For this reason, the use of an emergency ambulance system alone affects the prognosis negatively and it is necessary to evaluate such geriatric patients more carefully.
{"title":"Investigation of the relationship between emergency department applications and prognoses of geriatric patients","authors":"Ş. Savrun, A. Savrun","doi":"10.5455/medscience.2022.11.234","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.234","url":null,"abstract":"The World Health Organization (WHO) stated that the elderly population constituted 12% of the population of people over 60 years old in 2015. In the coming years, by 2030, 1 out of 6 people in the world will be 60 years or older, and this ratio will increase to 22% in 2050. In addition, it is estimated that the proportion of the elderly population will be 11.0% in 2025, 12.9% in 2030, 16.3% in 2040, 22.6% in 2060 and 25.6% in 2080. The number of admissions to the emergency services of geriatric patients, the hospital treatment process, and even the mortality and morbidity rates increase in elderly patients. In this direction, it was aimed to retrospectively analyze the data of patients over 65 who applied to a tertiary hospital emergency department and determine the factors affecting the mortality of geriatric patients. The presented study is a cross-sectional and retrospective study. All patients over the age of 65 who applied to the emergency department of Ordu University Medical Faculty Training and Research Hospital between 01 July 2022 and 31 2022 were retrospectively analyzed. Demographic features of the cases, the way they applied to the emergency room (112 Emergency Service Ambulance, others: with their own vehicle, by taxi, etc.), the last diagnosis in the emergency department (neurological, cardiovascular, respiratory, metabolic, trauma and others), treatment methods (outpatient, inpatient, intensive care), their motility and the relationship of these data with each other were examined. Between the specified dates, a total of 28459 patients over the age of 18 were admitted to the emergency department. It was determined that 10.16% (n=2894) of these patients consisted of patients over 65 years of age. The relationship between the treatment modalities and mortality according to the way the patients came to the hospital was found to be statistically significant (p<0.005). The relationship between hospitalization, treatment modalities and mortality was statistically significant according to the clinical diagnosis of the cases (p<0.005). In the presented study, it was determined that the mortality of patients who applied to the emergency department due to metabolic problems and who used the ambulance system as a referral tool was high. In fact, the prognosis of geriatric patients who apply to the emergency department for any reason, especially by using the emergency ambulance system, is worse than those who do not use the emergency ambulance system. For this reason, the use of an emergency ambulance system alone affects the prognosis negatively and it is necessary to evaluate such geriatric patients more carefully.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78424778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.06.084
Pinar Akdur, N. Ciledag, B. Savran, Ayse Duran
In this study, we aimed to investigate the concept of pseudoprogression in colorectal cancer patients with liver metastases receiving bevacizumab treatment by considering the changes in the shape, size, and density of liver metastases by abdominal Computed Tomography (CT) scans taken before and after treatment. This study is a retrospective evaluation of 16 patients with metastatic colorectal cancer treated with 5-fluorouracil, leucovorin, irinotecan and bevacizumab and is based on computed tissue analysis of the dominant liver lesion at baseline and 2 months after chemotherapy. The borders of all metastatic lesions observed in the livers of patients treated with bevacizumab after adjuvant chemotherapy were sharpened, the size of some lesions remained the same while others increased, and the density of most metastatic lesions decreased. In our study, we concluded that the evaluation of response to treatment based only on size and number should be avoided by noting a pseudoprogression in liver metastases that shows an increase in size but no progression on clinical/laboratory and follow-up images.
{"title":"Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy","authors":"Pinar Akdur, N. Ciledag, B. Savran, Ayse Duran","doi":"10.5455/medscience.2023.06.084","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.084","url":null,"abstract":"In this study, we aimed to investigate the concept of pseudoprogression in colorectal cancer patients with liver metastases receiving bevacizumab treatment by considering the changes in the shape, size, and density of liver metastases by abdominal Computed Tomography (CT) scans taken before and after treatment. This study is a retrospective evaluation of 16 patients with metastatic colorectal cancer treated with 5-fluorouracil, leucovorin, irinotecan and bevacizumab and is based on computed tissue analysis of the dominant liver lesion at baseline and 2 months after chemotherapy. The borders of all metastatic lesions observed in the livers of patients treated with bevacizumab after adjuvant chemotherapy were sharpened, the size of some lesions remained the same while others increased, and the density of most metastatic lesions decreased. In our study, we concluded that the evaluation of response to treatment based only on size and number should be avoided by noting a pseudoprogression in liver metastases that shows an increase in size but no progression on clinical/laboratory and follow-up images.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78642693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.12.260
Aslihan Ozturk, F. Erpala
The diagnosis of pregnancy-related carpal tunnel syndrome (PRCTS) was made with noninvasive methods and evaluated the effect of PRCTS on quality of life, its treatment and prognosis. Third-trimester pregnant women between the ages of 18-45 and diagnosed with PRCTS were included. For diagnosis; the presence of pain, positive motor and sensory tests, Carpal Tunnel Symptoms Scale-6 (CTS-6), and Boston Carpal Tunnel Questionnaire (BCTQ) were evaluated. The criteria used to determine improvement were the regression of complaints and symptoms based on a VAS score of 0 and a CTS-6 score of less than 5. According to these criteria, patients whose complaints regressed in the postpartum eighth week were called group A, whose complaints regressed in the postpartum sixth month were called group B, and women who still did not meet the criteria were called group C. The study included 102 wrists of 94 women. When the type of delivery, gestational age at birth, gravida, and parity were compared according to the continuity of complaints and symptoms, no differences were found. When the first trimester body mass index (BMI) measurements were compared between groups A and B, it was observed that group B had higher first trimester BMI values; this difference was statistically significant. The mean age was 29.2 years in group A, was 32.6 years in group B and the difference was significant. Conclusions: We recommend that pregnant women over 30 years old with a high BMI should be screened for PRCTS using non-invasive diagnostic tools, CTS-6, and VAS.
{"title":"Pregnancy-related carpal tunnel syndrome; non-invasive early diagnosis and postpartum evaluation","authors":"Aslihan Ozturk, F. Erpala","doi":"10.5455/medscience.2022.12.260","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.260","url":null,"abstract":"The diagnosis of pregnancy-related carpal tunnel syndrome (PRCTS) was made with noninvasive methods and evaluated the effect of PRCTS on quality of life, its treatment and prognosis. Third-trimester pregnant women between the ages of 18-45 and diagnosed with PRCTS were included. For diagnosis; the presence of pain, positive motor and sensory tests, Carpal Tunnel Symptoms Scale-6 (CTS-6), and Boston Carpal Tunnel Questionnaire (BCTQ) were evaluated. The criteria used to determine improvement were the regression of complaints and symptoms based on a VAS score of 0 and a CTS-6 score of less than 5. According to these criteria, patients whose complaints regressed in the postpartum eighth week were called group A, whose complaints regressed in the postpartum sixth month were called group B, and women who still did not meet the criteria were called group C. The study included 102 wrists of 94 women. When the type of delivery, gestational age at birth, gravida, and parity were compared according to the continuity of complaints and symptoms, no differences were found. When the first trimester body mass index (BMI) measurements were compared between groups A and B, it was observed that group B had higher first trimester BMI values; this difference was statistically significant. The mean age was 29.2 years in group A, was 32.6 years in group B and the difference was significant. Conclusions: We recommend that pregnant women over 30 years old with a high BMI should be screened for PRCTS using non-invasive diagnostic tools, CTS-6, and VAS.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78759314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.12.272
Muge Karadag, Seva Ecin, S. Turkkan, Z. Aytemur, S. Hacievliyagil
Sick building syndrome (SBS) is defined as symptoms that occur while living or working in a certain building but disappear after moving away from the environment. In this study, we aimed to determine the effects of indoor air pollutants on the health of employees, the prevalence of SBS in healthcare workers at the university hospital, its relationship with environmental and personal factors and the respiratory system. A questionnaire was applied to 951 healthcare workers who agreed to participate in the study. Having at least one general, one mucosal and one skin symptom every week in the last 3 months was accepted as SBS. Temperature, CO and CO2 levels and relative humidity were measured in different areas of the hospital. The prevalence of SBS was 62.1%. There was a statistically significant relationship between SBS and having a chronic disease (p<0.0001), continuous drug use (p=0.005) and the evaluation of the environment as warm (p=0.042). Having a chronic disease (OR=0.426; 95% CI, 0.228–0.797), the environment often being too warm (OR 0.218; 95% CI, 0.084–0.567) or occasionally too bright (OR=0.300; 95% CI, 0.158–0571) and diagnosed by a doctor due to symptoms (OR=3.209; 95% CI, 1.529–6.731) was found to be significant in forward variable selection method and binary logistic regression analysis. In our study, a relationship was found between physical factors such as temperature, humidity and CO2 level of the environment and personal factors such as stress, chronic disease and SBS. SBS can be prevented by control at the source as well as by administrative and engineering interventions among the employees.
{"title":"The affecting factors and prevalence rate of sick building syndrome in healthcare workers","authors":"Muge Karadag, Seva Ecin, S. Turkkan, Z. Aytemur, S. Hacievliyagil","doi":"10.5455/medscience.2022.12.272","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.272","url":null,"abstract":"Sick building syndrome (SBS) is defined as symptoms that occur while living or working in a certain building but disappear after moving away from the environment. In this study, we aimed to determine the effects of indoor air pollutants on the health of employees, the prevalence of SBS in healthcare workers at the university hospital, its relationship with environmental and personal factors and the respiratory system. A questionnaire was applied to 951 healthcare workers who agreed to participate in the study. Having at least one general, one mucosal and one skin symptom every week in the last 3 months was accepted as SBS. Temperature, CO and CO2 levels and relative humidity were measured in different areas of the hospital. The prevalence of SBS was 62.1%. There was a statistically significant relationship between SBS and having a chronic disease (p<0.0001), continuous drug use (p=0.005) and the evaluation of the environment as warm (p=0.042). Having a chronic disease (OR=0.426; 95% CI, 0.228–0.797), the environment often being too warm (OR 0.218; 95% CI, 0.084–0.567) or occasionally too bright (OR=0.300; 95% CI, 0.158–0571) and diagnosed by a doctor due to symptoms (OR=3.209; 95% CI, 1.529–6.731) was found to be significant in forward variable selection method and binary logistic regression analysis. In our study, a relationship was found between physical factors such as temperature, humidity and CO2 level of the environment and personal factors such as stress, chronic disease and SBS. SBS can be prevented by control at the source as well as by administrative and engineering interventions among the employees.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79321413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.11.233
E. Esen, M. Saydam, Sumeyra Guler, K. Yılmaz, M. Turan, P. Demır, M. Gulcelik
{"title":"Comparison of lymph node metastasis rates in breast cancer molecular subtypes; A retrospective clinical study","authors":"E. Esen, M. Saydam, Sumeyra Guler, K. Yılmaz, M. Turan, P. Demır, M. Gulcelik","doi":"10.5455/medscience.2022.11.233","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.233","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79491365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.05.077
B. Barut, Cengiz Ceylan
In this study, we aimed to investigate the pre-operative predictive role of the serum white blood cell and platelet counts, C-reactive protein (CRP), bilirubin, amylase, lipase, and sodium levels for complicated appendicitis in patients aged≥18 years. We retrospectively evaluated 574 patients (aged≥18 years) who underwent appendectomy due to acute appendicitis (AA) between March 2018 and March 2022 at our clinic. The patient population was divided into two groups as perioperative complicated and uncomplicated appendicitis and the preoperative predictor role of serum white blood cell counts, platelet counts, CRP, bilirubin, amylase, lipase, and sodium levels were compared for complicated versus uncomplicated appendicitis. In multivariate analyses, age>38 years, the timing of Emergency Department (ED) arrival to admission ≥2 days, CRP ≥3.36 mg/dL, and total bilirubin ≥0.76 mg/dL are independent risk factors for detecting complicated AA. Moreover, in the designed scoring system, the AUC: 0.877 (CI: 0.847-0.907) for perforated AA at scores below or above. Estimation of the complications of AA can help clinicians practically with the scoring system designed because of the determined predictive factors.
{"title":"Preoperative predictor laboratory markers for complicated appendicitis: A retrospective analysis of single center experience","authors":"B. Barut, Cengiz Ceylan","doi":"10.5455/medscience.2023.05.077","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.077","url":null,"abstract":"In this study, we aimed to investigate the pre-operative predictive role of the serum white blood cell and platelet counts, C-reactive protein (CRP), bilirubin, amylase, lipase, and sodium levels for complicated appendicitis in patients aged≥18 years. We retrospectively evaluated 574 patients (aged≥18 years) who underwent appendectomy due to acute appendicitis (AA) between March 2018 and March 2022 at our clinic. The patient population was divided into two groups as perioperative complicated and uncomplicated appendicitis and the preoperative predictor role of serum white blood cell counts, platelet counts, CRP, bilirubin, amylase, lipase, and sodium levels were compared for complicated versus uncomplicated appendicitis. In multivariate analyses, age>38 years, the timing of Emergency Department (ED) arrival to admission ≥2 days, CRP ≥3.36 mg/dL, and total bilirubin ≥0.76 mg/dL are independent risk factors for detecting complicated AA. Moreover, in the designed scoring system, the AUC: 0.877 (CI: 0.847-0.907) for perforated AA at scores below or above. Estimation of the complications of AA can help clinicians practically with the scoring system designed because of the determined predictive factors.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78152273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.12.276
Erdem Ozden, A. Aybar
The navicular bone of the hand is the most frequently fractured bone among the carpal bones, and if not treated well, it may result in nonunion. Dorsal, volar open, or percutaneous approaches can be used in surgical treatment. We aimed to evaluate the results of internal fixation of scaphoid fractures with the dorsal mini-open technique. Patients with acute proximal and waist fractures who have been treated with cannulated compression screws with a dorsal mini open approach without grafting between 2015 and 2020 were included. Functional outcomes were analyzed with the DASH questionnaire and MAYO wrist performance scores and compared with the contralateral wrists. The mean age of the patients was 35.6 ±10.8 years (range 20-55), seven were proximal, and 13 were waist fractures. The mean time to surgery was 16±7.3 days (range 5-30) and the mean follow-up time was 47.5±20.2 weeks (range 20-84). The mean DASH score at the last follow-up was 5.9±3.3 points (range 2.5-11.7), and the Mayo wrist performance score was 96.8±5.2 points (range 85-100). In one proximal pole fracture, cracking occurred on the cartilage surface at the screw insertion site but consolidated without any additional intervention. The mean time to union was 8.5±1.2 weeks (range 7-11). Waist region fractures consolidated faster than proximal pole fractures (p=0.002). No significant difference was found between the fracture site and mid-term functional results. Complications like proximal cartilage fractures during the embedding of the screw head or prominence of the screw head can be avoided with the dorsal mini-open technique which is a safe and effective method.
{"title":"Internal fixation of acute scaphoid proximal pole & waist fractures using the dorsal mini open technique without bone grafting","authors":"Erdem Ozden, A. Aybar","doi":"10.5455/medscience.2022.12.276","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.276","url":null,"abstract":"The navicular bone of the hand is the most frequently fractured bone among the carpal bones, and if not treated well, it may result in nonunion. Dorsal, volar open, or percutaneous approaches can be used in surgical treatment. We aimed to evaluate the results of internal fixation of scaphoid fractures with the dorsal mini-open technique. Patients with acute proximal and waist fractures who have been treated with cannulated compression screws with a dorsal mini open approach without grafting between 2015 and 2020 were included. Functional outcomes were analyzed with the DASH questionnaire and MAYO wrist performance scores and compared with the contralateral wrists. The mean age of the patients was 35.6 ±10.8 years (range 20-55), seven were proximal, and 13 were waist fractures. The mean time to surgery was 16±7.3 days (range 5-30) and the mean follow-up time was 47.5±20.2 weeks (range 20-84). The mean DASH score at the last follow-up was 5.9±3.3 points (range 2.5-11.7), and the Mayo wrist performance score was 96.8±5.2 points (range 85-100). In one proximal pole fracture, cracking occurred on the cartilage surface at the screw insertion site but consolidated without any additional intervention. The mean time to union was 8.5±1.2 weeks (range 7-11). Waist region fractures consolidated faster than proximal pole fractures (p=0.002). No significant difference was found between the fracture site and mid-term functional results. Complications like proximal cartilage fractures during the embedding of the screw head or prominence of the screw head can be avoided with the dorsal mini-open technique which is a safe and effective method.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83474084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.12.279
Z. Agaç, S. Karaahmetoğlu, T. Akyol
Early differentiation of cases with severe acute cholangitis is important for optimal treatment. In this study, it was aimed to elucidate the prognosis with complete blood count parameters among patients with acute cholangitis. Clinical and laboratory findings of 200 patients with acute cholangitis at Ankara City Hospital between February 2019 and October 2019 were retrospectively analyzed. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, red cell distribution width and mean platelet volume levels were recorded from blood analysis at the time of admission. According to Tokyo guidelines, patients were divided into 3 groups as mild, moderate and severe acute cholangitis. In order to evaluate the prognosis, the length of hospital stay, the status of hospitalization in the medical intensive care unit and blood culture growth were investigated with hematological parameters. Of the 200 patients, 109 (54.5%) were male and 91 (45.5%) were female. According to Tokyo criteria, 17 patients’ status was evaluated as severe, 70 as moderate and 113 as mild acute cholangitis. The area under the receiver operating characteristics curve for neutrophil-lymphocyte ratio measurements was statistically significant in distinguishing the mild vs moderate disease (AUC=0.694; 95% Confidence Interval (CI):0.586-0.802 and p=0.008), with a diagnostic accuracy rate of 59.5%. The diagnostic accuracy rate of red cell distribution width (AUC=0.603; 95% CI: 0.523-0.683 and p=0.013) was 61.5% and the diagnostic accuracy rate of mean platelet volume (AUC=0.582 95% CI: 0.502-0.662 and p=0.047) was 57.5% achieving a statistical significance. Neutrophil-lymphocyte ratio, red cell distribution width and mean platelet volume analysis is routinely obtained from complete blood count almost in every patient. These are inexpensive and easily accessible diagnostic markers and thus, might be useful in the differentiation of mild and severe acute cholangitis patients and their prognosis.
{"title":"Evaluation of prognosis of acute colangitis patients via hematological parameters","authors":"Z. Agaç, S. Karaahmetoğlu, T. Akyol","doi":"10.5455/medscience.2022.12.279","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.279","url":null,"abstract":"Early differentiation of cases with severe acute cholangitis is important for optimal treatment. In this study, it was aimed to elucidate the prognosis with complete blood count parameters among patients with acute cholangitis. Clinical and laboratory findings of 200 patients with acute cholangitis at Ankara City Hospital between February 2019 and October 2019 were retrospectively analyzed. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, red cell distribution width and mean platelet volume levels were recorded from blood analysis at the time of admission. According to Tokyo guidelines, patients were divided into 3 groups as mild, moderate and severe acute cholangitis. In order to evaluate the prognosis, the length of hospital stay, the status of hospitalization in the medical intensive care unit and blood culture growth were investigated with hematological parameters. Of the 200 patients, 109 (54.5%) were male and 91 (45.5%) were female. According to Tokyo criteria, 17 patients’ status was evaluated as severe, 70 as moderate and 113 as mild acute cholangitis. The area under the receiver operating characteristics curve for neutrophil-lymphocyte ratio measurements was statistically significant in distinguishing the mild vs moderate disease (AUC=0.694; 95% Confidence Interval (CI):0.586-0.802 and p=0.008), with a diagnostic accuracy rate of 59.5%. The diagnostic accuracy rate of red cell distribution width (AUC=0.603; 95% CI: 0.523-0.683 and p=0.013) was 61.5% and the diagnostic accuracy rate of mean platelet volume (AUC=0.582 95% CI: 0.502-0.662 and p=0.047) was 57.5% achieving a statistical significance. Neutrophil-lymphocyte ratio, red cell distribution width and mean platelet volume analysis is routinely obtained from complete blood count almost in every patient. These are inexpensive and easily accessible diagnostic markers and thus, might be useful in the differentiation of mild and severe acute cholangitis patients and their prognosis.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82112649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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