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Frequency of GERD in women of childbearing age in Malatya region 马拉提亚地区育龄妇女胃食管反流的发生率
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.01.12
H. Aladag, M. Aladağ
Gastroesophageal reflux disease (GERD) is frequently seen not only in our country but also all over the world. GERD not only impairs health and quality of life, but also causes serious financial losses in the working population. In this study, our aim is to determine the frequency of gastroesophageal reflux disease among female healthcare professionals of childbearing age in our region. Questions were asked about demographic data such as weight, age, height, BMI, medical history, and gastroesophageal reflux of female healthcare workers, whose data were generated by us. The answers to the questionnaires were collected and evaluated retrospective. All participants in the study were women. This study was carried out on 1224 female healthcare workers of reproductive age working in Malatya Turgut Özal University training and research hospital. Approximately 1150 of the employees who were distributed questionnaires filled out the questionnaires. The mean age of the female healthcare workers of childbearing age was 30.01±5.38 years, between 19-50. The mean height of the healthcare workers was 1.64±7.8 meters, the average weight was 68.05±13.2 kg, and their body mass index (BMI) was 27.4±3.6 kg/m². The frequency of GERD in the study group was found to be positive in 24%. 38.5% of the healthcare workers had previously gone to the doctor with complaints of pyrosis and/or regurgitation. A significant relationship was found between GERD and stress, fizzy drinks, lying down after meals, and family history of GERD. There was no significant relationship between the smoking and coffee use and age of the participants in the study in terms of the presence of GERD.We think that gastroesophageal reflux symptoms are common due to stress, unbalanced diet, irregular sleep and lifestyle habits due to the COVID pandemic in the last two years due to the fact that the participants in the study were healthcare professionals. Among our healthcare professionals, both pyrosis and other GERD symptoms were found to be higher than some of the previous studies, similar to those in our country. We think that the reason for this is that the extremely stressful work of health workers in the last 2 years has contributed to this. As it is known, health workers have worked very hard in the last 2 years, they did not even use their annual leaves, even those who wanted to retire could not retire. We think that this stress environment may also contribute to GERD symptoms.
胃食管反流病(GERD)不仅在我国,而且在世界各地都很常见。胃食管反流症不仅损害健康和生活质量,而且给劳动人口造成严重的经济损失。在本研究中,我们的目的是确定本地区育龄女性保健专业人员胃食管反流病的频率。我们对女性医护人员的体重、年龄、身高、BMI、病史、胃食管反流等人口统计数据进行了询问,这些数据由我们生成。收集问卷的答案并进行回顾性评价。该研究的所有参与者都是女性。本研究以马拉提亚图尔古特Özal大学培训与研究医院1224名育龄女性卫生保健工作者为研究对象。大约有1150名员工填写了调查问卷。育龄女医护人员平均年龄为30.01±5.38岁,年龄在19 ~ 50岁之间。平均身高1.64±7.8米,平均体重68.05±13.2 kg,身体质量指数(BMI) 27.4±3.6 kg/m²。研究组胃食管反流发生率为24%。38.5%的医护人员曾因发热和/或反流就诊。胃反流与压力、碳酸饮料、饭后躺卧和胃反流家族史之间存在显著关系。在研究中,吸烟和喝咖啡与参与者的年龄之间没有明显的关系,就胃反流的存在而言。我们认为胃食管反流症状很常见,这是由于过去两年因COVID大流行而导致的压力、饮食不平衡、睡眠不规律和生活习惯,因为研究的参与者是医疗保健专业人员。在我们的医疗保健专业人员中,发现灼热和其他GERD症状都高于先前的一些研究,与我国的研究相似。我们认为,造成这种情况的原因是卫生工作者在过去两年中压力极大的工作造成了这种情况。众所周知,在过去的两年里,卫生工作者工作非常努力,他们甚至没有使用年假,甚至那些想退休的人也不能退休。我们认为这种应激环境也可能导致胃反流症状。
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引用次数: 0
The beneficial effects of ivabradine against myocardial damage induced by isoproterenol in rats 伊伐布雷定对异丙肾上腺素所致大鼠心肌损伤的有益作用
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.03.042
S. Polat, Miray Altuntas, M. Gunata, A. Polat, L. Tanrıverdi, A. Yıldız, M. Durhan, N. Vardı, Y. Cigremis, H. Acet, H. Parlakpınar
We aimed to investigate the potential benefits of two doses of ivabradine (IVA)-an If sodium channel blocker against isoproterenol (ISO)-induced myocardial damage in rats.The rats were randomly divided into 4 groups: Control group (n=8); Saline was administered, ISO group (n=12); 150 mg/kg ISO was administered for 2 days, ISO+IVA (1 mg/kg) group (n=12); 1 mg/kg IVA was administered for 4 days in addition to ISO. ISO+IVA (10 mg/kg) group (n=12): 10 mg/kg IVA was administered for 4 days in addition to ISO. Thereafter, hemodynamic, histopathological, and biochemical studies were performed. In the ISO+IVA (1 mg/kg) and ISO+IVA (10 mg/kg) groups, ISO-induced myocardial changes including an increase in density of granulation tissue and degenerated cardiomyocyte were equally decreased. HR was mildly reduced, and arterial blood pressures were slightly increased in the IVA-treated groups versus the ISO group. In the hearts of IVA-treated groups, malondialdehyde (MDA) levels were significantly reduced and glutathione (GSH) level and catalase (CAT) activity were mildly increased compared to the ISO group. Elevation of GSH and CAT activity were more pronounced in the ISO+IVA (10 mg/kg) group. Our results indicate that both 1 mg/kg and 10 mg/kg doses of IVA are effective against heart damage induced by ISO via its negative chronotropic, anti-oxidant (dose-dependent), anti-inflammatory and anti-degenerative properties.
我们的目的是研究两种剂量的伊伐布雷定(IVA)和If钠通道阻滞剂对异丙肾上腺素(ISO)诱导的大鼠心肌损伤的潜在益处。将大鼠随机分为4组:对照组(n=8);给予生理盐水,ISO组(n=12);150 mg/kg ISO给药2 d, ISO+IVA (1 mg/kg)组(n=12);在ISO基础上给予IVA 1 mg/kg,连续4天。ISO+IVA (10 mg/kg)组(n=12):在ISO基础上给予10 mg/kg IVA,连续4 d。然后进行血流动力学、组织病理学和生化研究。在ISO+IVA (1 mg/kg)和ISO+IVA (10 mg/kg)组中,ISO诱导的心肌变化,包括肉芽组织密度的增加和心肌细胞的退化,都同样减少。与ISO组相比,iva治疗组HR轻度降低,动脉血压略有升高。与ISO组相比,iva处理组心脏丙二醛(MDA)水平显著降低,谷胱甘肽(GSH)水平和过氧化氢酶(CAT)活性轻度升高。在ISO+IVA (10 mg/kg)组,GSH和CAT活性升高更为明显。我们的研究结果表明,1mg /kg和10mg /kg剂量的IVA通过其负变时性、抗氧化(剂量依赖性)、抗炎和抗退行性对ISO引起的心脏损伤有效。
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引用次数: 0
Sedation-free upper gastrointestinal endoscopy and its cost-effectiveness 无镇静上消化道内窥镜检查及其成本效益
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.06.090
Kubilay Oztutuncu
This study aimed to determine the success rate of sedation-free upper gastrointestinal (GI) endoscopy and evaluate the cost-effectiveness of this drug-free approach.The study included patients who underwent gastroscopy between February 2020 and December 2022. Demographic information such as age and gender, along with clinical data including whether the procedure was performed with sedation and the patients' tolerance status, were recorded. Statistical analysis revealed no significant difference between the sedation and sedation-free groups in terms of procedural success. Interestingly, a notable cost difference of 43% was observed between the two groups, with the sedation-free group demonstrating higher cost-effectiveness. Despite the nearly 50% higher cost associated with administering sedation, there was no significant disparity in the successful completion of the procedure between the two groups. The findings of this study indicate that sedation-free upper GI endoscopy can achieve comparable success rates to the sedation-assisted approach. Moreover, the cost-effectiveness analysis highlights the economic advantage of the drug-free alternative, given the substantial cost reduction observed in the sedation-free group. This study underscores the feasibility of implementing sedation-free procedures as a cost-effective and successful option for upper GI endoscopy
本研究旨在确定无镇静上消化道内镜的成功率,并评估这种无药物方法的成本-效果。该研究包括在2020年2月至2022年12月期间接受胃镜检查的患者。记录了年龄和性别等人口统计信息,以及临床数据,包括手术是否使用镇静和患者的耐受性状况。统计分析显示镇静组和非镇静组在手术成功率方面无显著差异。有趣的是,在两组之间观察到43%的显著成本差异,无镇静组表现出更高的成本效益。尽管使用镇静的费用高出近50%,但两组在成功完成手术方面没有显着差异。本研究结果表明,无镇静的上消化道内镜可以达到与镇静辅助入路相当的成功率。此外,成本效益分析强调了无药物替代方案的经济优势,因为在无镇静组中观察到大量的成本降低。本研究强调了在上消化道内镜检查中实施无镇静手术的可行性,这是一种经济有效且成功的选择
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引用次数: 0
Prognostic and diagnostic importance of the systemic immune-inflammation index in pediatric head trauma 全身性免疫炎症指数对儿童头部创伤预后和诊断的重要性
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.05.061
K. Şener, A. Çakır, H. Toksul, Halil Olmez, M. Tuğcan, E. Altuğ, R. Guven
Head trauma is a leading cause of mortality and morbidity in pediatric patients. The trauma itself leads to the activation of a biomolecular cascade of damage. Purinergic receptors and ATP release play an important role in the activation of astroglia, microglia, monocyte-macrophages, neutrophils, and T cells in this process. The systemic immune inflammation index can be easily calculated, cheap, only requires hemogram parameters, and does not include any subjective findings. Therefore, we believe that it could be a prognostic predictor and a diagnostic marker for pediatric head trauma cases. Our study was designed as a retrospective and single-center study. The study was conducted with pediatric patients who presented to the emergency department with isolated head trauma between June 15, 2022, and December 15, 2022. Demographic data, medical history, white blood count, platelet count, neutrophil count, systemic immune inflammation index (SIII), Glasgow Coma Score, and the presence of pathology on brain computed tomography were recorded on the case report form. The study was conducted with 112 cases. In cases with bleeding, the median value of GCS was significantly lower (p<0.001), while WBC, Neutrophil, Platelet, NLR and SIII were significantly higher (p=0.008, p=0.001, p<0.001, p=0.011, and p<0.001, respectively). There was no significant difference between lymphocyte values and bleeding status. We believe that a higher SIII may be associated with persistent pericontusional inflammation in the brain and may be a good marker for predicting intracranial pathology and prognosis of the pathology caused by head trauma.
头部创伤是儿科患者死亡和发病的主要原因。创伤本身会导致生物分子级联损伤的激活。嘌呤能受体和ATP的释放在星形胶质细胞、小胶质细胞、单核巨噬细胞、中性粒细胞和T细胞的激活过程中起着重要作用。全身免疫炎症指数可以很容易地计算,便宜,只需要血象参数,不包括任何主观发现。因此,我们认为它可以作为儿童头部创伤病例的预后预测因子和诊断标志。本研究设计为回顾性单中心研究。该研究是在2022年6月15日至2022年12月15日期间因孤立性头部创伤就诊于急诊科的儿科患者中进行的。病例报告表上记录患者的人口统计资料、病史、白细胞计数、血小板计数、中性粒细胞计数、全身免疫炎症指数(SIII)、格拉斯哥昏迷评分(Glasgow Coma Score)以及脑部计算机断层扫描有无病理。该研究对112例患者进行了研究。出血组GCS中值显著降低(p<0.001), WBC、中性粒细胞、血小板、NLR、SIII中值显著升高(p=0.008、p=0.001、p<0.001、p=0.011、p<0.001)。淋巴细胞值与出血情况无显著差异。我们认为,较高的SIII可能与脑部持续的裂孔周围炎症有关,并且可能是预测颅内病理和头部创伤引起的病理预后的良好标志。
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引用次数: 0
Gallbladder duplication accompanied by gallstones: A rare congenital anomaly 胆囊复制伴胆结石:一种罕见的先天性异常
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2022.11.249
M. Goksu, H. Alakus, Mahmut Corapli, B. Turk, F. Daghan
Gallbladder diseases are among the most common pathologies requiring surgical intervention in general surgery practice. Gallbladder duplication is a rare anomaly of the biliary system. Congenital anomalies and anatomical variations of the gallbladder constitute one of the significant difficulties encountered by surgeons since these variations can cause great uncertainty in defining the anatomical structures of the gallbladder and may lead to significant complications during surgery. Congenital malformations are important predisposing factors for iatrogenic bile duct injuries during cholecystectomy. This case report presents a case of symptomatic gallbladder duplication and a double cystic duct treated with laparoscopic cholecystectomy.
胆囊疾病是普通外科实践中最常见的需要手术干预的病理之一。胆囊重复是胆道系统中一种罕见的异常。胆囊的先天性异常和解剖变异是外科医生遇到的重大困难之一,因为这些变异会导致胆囊解剖结构定义的极大不确定性,并可能导致手术中严重的并发症。先天性畸形是胆囊切除术中医源性胆管损伤的重要易感因素。本病例报告一例有症状的胆囊重复和双胆囊管治疗腹腔镜胆囊切除术。
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引用次数: 0
Short-term outcomes of subtotal colectomy for splenic flexure tumors: a single-center experience 脾屈曲肿瘤次全结肠切除术的短期疗效:单中心研究
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.07.102
M. Aslan, Oktay Karakose
Splenic flexure tumors are a subtype of colon tumors whose treatment is still debated. We aim to evaluate the surgical methods and short-term outcomes of splenic flexure tumors. Fourteen patients with colonic tumors at or near the splenic flexure who underwent subtotal colectomy in the surgical oncology department of Samsun Training and Research Hospital between August 2017 and March 2020 were retrospectively evaluated in terms of postoperative morbidity, mortality, and early oncologic outcomes. Of the fourteen patients evaluated, twelve were urgent and two were elective. Four patients underwent additional organ resection as a curative surgery. The pathology was colonic adenocarcinoma in all patients, and the histotype was mucinous in five patients (35.7%). Lymph node positivity was detected in six patients (42.8%) and metastasis in one patient (7.1%). Postoperatively, two patients (14.2%) developed surgical site infection, and one patient (7.1%) died. Eight (57.1%) patients complained of more frequent defecation, with a mean bowel movement frequency of 3±1.6 times daily. Based on our clinical experience, subtotal colectomy is appropriate for emergency surgical treatment of splenic flexure tumors, whereas left hemicolectomy is appropriate under elective conditions.
脾屈性肿瘤是结肠肿瘤的一种亚型,其治疗方法仍有争议。我们的目的是评估手术方法和短期预后的脾脏屈曲肿瘤。回顾性分析了2017年8月至2020年3月在三星培训研究医院外科肿瘤科接受结肠次全切除术的14例脾屈或脾屈附近结肠肿瘤患者的术后发病率、死亡率和早期肿瘤预后。在评估的14名患者中,12名是紧急的,2名是选择性的。4例患者接受了额外的器官切除作为治疗手术。所有患者病理均为结肠腺癌,5例(35.7%)为黏液型。淋巴结阳性6例(42.8%),转移1例(7.1%)。术后2例(14.2%)发生手术部位感染,1例(7.1%)死亡。8例(57.1%)患者排便更频繁,平均排便次数为3±1.6次/天。根据我们的临床经验,结肠次全切除术适用于脾屈曲肿瘤的紧急手术治疗,而左结肠切除术适用于选择性条件。
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引用次数: 0
Dissoanalytic Psychohistory: Dissoanalysis of the Traumatic History of Humanity and the Construction of a New Societal Reality 精神分析心理史:人类创伤史的精神分析与新社会现实的建构
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.02.024
E. Ozturk
In the face of all the limitations and criticisms regarding the recognition of consciousness as a psychosocial "singularity experience", the construction of "Dissoanalysis Theory: Psychocommunal Therapy" centered on "multiple consciousness system", "multiple reality perception" and "multiple memory phenomenon", that is, a new societal reality, has become an indispensability. Based on trauma and dissociation studies, i.e. modern psychotraumatology paradigms and modalities, the "Dissoanalysis Theory", structured by Ozturk with the aim of creating a functional society consisting of empathetic, prudent, just, peaceful, and capable individuals, made it possible for the emergence of "dissoanalytic psychohistory" from a psychosocial perspective. Dissoanalytic psychohistory is intervention therapy for psychosocial crises! “Dissoanalytic psychohistory” structured by Ozturk within the framework of the dissoanalytic school is defined as a branch of science that does researches on childhood traumas, psychosocial perceptions of childhood, chronic oppressions, child-rearing styles, dysfunctional families, dysfunctional generations, intergenerational transmission of trauma, intergenerational transfer of psychopathology, psychocommunal dissociation, dominant leaders and mass violence and develops strategies focused on especially preventing childhood traumas and wars. Dissoanalytic psychohistory, emphasizing that the neutralization of dysfunctional generations and the future can be achieved by the administration of "psychocommunal therapy" of all nations in the world, is an original psychology theory that consists of a holistic synthesis of modern psychotraumatology and psychohistory paradigms with the study of intergenerational transmission of trauma and intergenerational transfer of psychopathology. Dissoanalytic psychohistory, which is the dissoanalysis of the traumatic history of humanity and the construction of a new societal reality, both analyzes and integrates the dissociative components of societies with absolute reality. Dissoanalytic psychohistory creates development-oriented shifts, “dissociative revolutions”, “integrative psychosocial movements” and “mass predictions” and even functional and healthy new society profiles by raising awareness of masses of human about their actions.
面对承认意识是一种社会心理“奇点体验”的种种局限和批评,以“多重意识系统”、“多重现实感知”和“多重记忆现象”为中心的“精神错乱理论:心理共同体治疗”的建构,即一种新的社会现实,已成为不可或缺的。基于创伤和分离研究,即现代心理创伤学范式和模式,Ozturk构建的“精神错乱理论”旨在创造一个由移情、谨慎、公正、和平和有能力的个体组成的功能社会,从社会心理角度来看,这使得“精神错乱心理史”的出现成为可能。精神分析史是心理社会危机的干预疗法!由Ozturk在精神分析学派框架内构建的"精神分析心理史"被定义为研究童年创伤的一个科学分支,对童年的社会心理感知,慢性压迫,育儿方式,不正常的家庭,不正常的世代,创伤的代际传递,精神病理学的代际转移,精神社区分离,支配性领导人和大规模暴力,并制定特别侧重于预防童年创伤和战争的战略。消解分析心理史学是一种全新的心理学理论,它将现代心理创伤学和心理史学范式综合起来,研究创伤的代际传递和精神病理学的代际转移。它强调通过对世界各国的“心理公共治疗”来实现对功能失调的代际和未来的中和。消解心理史学是对人类创伤史的消解和对新社会现实的建构,它将社会的解离成分与绝对现实进行分析和整合。通过提高大众对自身行为的认识,分析心理历史创造了以发展为导向的转变、“分离革命”、“综合心理社会运动”和“大众预测”,甚至创造了功能性和健康的新社会形象。
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引用次数: 0
The relationship between thigh and leg circumferences and proprioceptive sense: results of postoperative anterior cruciate ligament reconstruction 大腿和小腿围度与本体感觉之间的关系:前十字韧带重建术后的结果
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.01.015
Ahmet Gen, Nizamettin zel
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引用次数: 0
The mediating role of resilience and perceived stress in the relationship between childhood traumas and depression in young adults 心理弹性和感知压力在青少年童年创伤与抑郁关系中的中介作用
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.06.096
Emre Ciydem, E. Ozturk, Osman Usta, Gorkem Derin
It is still unclear whether childhood traumas cause depression by first decreasing the individual's resilience and impairing stress perception or by first increasing the individual's stress perception and impairing resilience. The aim of this study is to investigate the mediating role of resilience and perceived stress in the relationship between childhood trauma and depression in young adults. The convenience sample of the cross-sectional correlational study consisted of 481 young adults with at least one childhood trauma. The data was analysed with structural equation modeling. Childhood traumas may increase perceived stress level by decreasing resilience and both of them may lead to depressive symptoms. At the same time, it has been found that childhood traumas may decrease resilience by increasing the perceived stress level and both may lead to depressive symptoms. The childhood traumas-resilience-perceived stress-depression pathway and childhood traumas-perceived stress-resilience-depression pathway were found to be significant.
目前尚不清楚童年创伤是首先降低个体的适应能力和损害压力感知,还是首先增加个体的压力感知和损害适应能力。本研究旨在探讨心理弹性和感知压力在青少年童年创伤与抑郁之间的中介作用。横断面相关研究的方便样本包括481名至少有一次童年创伤的年轻人。采用结构方程模型对数据进行分析。童年创伤可能通过降低恢复力而增加感知压力水平,两者都可能导致抑郁症状。与此同时,研究发现,童年创伤可能通过增加感知压力水平来降低恢复力,两者都可能导致抑郁症状。儿童创伤-恢复-知觉压力-抑郁通路和儿童创伤-知觉压力-恢复-抑郁通路显著。
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引用次数: 0
Evaluation of some biochemical parameters of pediatric patients hospitalized for rotavirus in Şirnak Province: A retrospective review Şirnak省小儿轮状病毒住院患者生化指标的回顾性分析
Pub Date : 2023-01-01 DOI: 10.5455/medscience.2023.07.100
Erhan Sonmez, Veysel Tahiroğlu, Erkam Coşkun, N. Alayunt
Rotavirus gastroenteritis is an important cause of worldwide morbidity and mortality in infants and children. The main cause of mortality is dehydration due to fluid loss and malnutrition. This study aims to examine the guiding parameters of uric acid and creatinine levels in the detection of dehydration and fluid deficit and inpatient management in cases of rotavirus gastroenteritis. Children who applied to Şirnak State Hospital, Pediatrics Polyclinics, children (6 months-18 years old) whose faecal samples were sent to the laboratory by the research pediatrician considering the diagnosis of rotavirus and whose microbiological examinations were confirmed by immunochromatographic methods (6 months-18 years old), were included in the study by scanning the system. When positive patients were evaluated, the mean age for serum uric acid was 1.06±1.53 and the mean age for serum creatinine was 1.10±1.37. The median value was 3.75 mg/dL in negative patients with serum uric acid levels, and 5.25 mg/dL in positive patients, which was statistically significant (p<0.01). The median value of serum creatinine level was 0.41 mg/dL in negative patients and 0.43 mg/dL in positive patients, which was statistically significant (p<0.05). With this study carried out in Şirnak province, we think that children in the region are severely affected by the rotavirus and face severe dehydration. Therefore, we think that all parameters affected by rotavirus should be evaluated according to regions and parents should be educated about the importance of rotavirus vaccine in the prevention of rotavirus gastroenteritis.
轮状病毒胃肠炎是世界范围内婴儿和儿童发病率和死亡率的重要原因。死亡的主要原因是体液流失和营养不良造成的脱水。本研究旨在探讨尿酸和肌酐水平在轮状病毒胃肠炎病例脱水和体液不足检测和住院治疗中的指导参数。申请Şirnak国立医院儿科综合诊所的儿童,经研究儿科医生考虑轮状病毒诊断将粪便样本送到实验室并经免疫层析方法确认微生物学检查的儿童(6个月-18岁),通过系统扫描纳入研究。阳性患者血清尿酸平均年龄为1.06±1.53岁,血清肌酐平均年龄为1.10±1.37岁。血清尿酸水平阴性患者中位值为3.75 mg/dL,阳性患者中位值为5.25 mg/dL,差异有统计学意义(p<0.01)。阴性患者血清肌酐水平中位数为0.41 mg/dL,阳性患者血清肌酐水平中位数为0.43 mg/dL,差异有统计学意义(p<0.05)。这项研究在Şirnak省进行,我们认为该地区的儿童受到轮状病毒的严重影响,面临严重脱水。因此,我们认为应根据地区对受轮状病毒影响的所有参数进行评估,并应教育家长了解轮状病毒疫苗在预防轮状病毒胃肠炎中的重要性。
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引用次数: 0
期刊
Medicine Science | International Medical Journal
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