Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.08.147
Meltem Pusuroglu, Bayram Kizilkaya
Helicobacter pylori gastritis is an infection frequently observed around the world. In our research, the effect of Helicobacter pylori positivity on depression and somatosensory amplification was investigated. The research included a total of 112 patients with dyspeptic complaints, 52 Helicobacter pylori positive and 60 Helicobacter pylori negative, and a healthy control group of 54 cases without any complaints. Participants completed the Beck Depression Inventory and the Somatosensory Amplification Scale. There was no effect of Helicobacter pylori positivity on depression levels (p=0.116), while Helicobacter pylori positivity had a significant effect on somatosensory amplification (F=6.794; p=0.010; η2=0.40). There were significant effects of dyspeptic complaints on depression levels (F=6.695; p=0.011; η2=0.039) and somatosensory amplification (F=7.554; p=0.007; η2=0.044). It was identified that somatosensory amplification, sex and family history were each statistically significant explanatory variables for depression (p=0.001 β2=0.255; p=0.038 β2=0.150; p=0.002 β2=0.230). There was a 0.269 increase in depression for each 1-unit increase in somatosensory amplification, the female sex increased depression by 2.463 units and positive family history increased it by 4.949 units. Helicobacter pylori positivity was not found to be a significant explanatory variable for depression (p=0.412). While Helicobacter pylori positivity did not have an effect on depression, it was found to be effective in somatosensory amplification. The presence of dyspeptic complaints was effective on both depression and somatosensory amplification. Somatosensory amplification was one of the factors predicting depression in patients with dyspeptic complaints. Somatosensory amplification is an important factor in patients with Helicobacter pylori positivity and dyspeptic complaints. Mental diseases should not be ignored during the monitoring and treatment of this patient group.
{"title":"Effect of helicobacter pylori positivity and dyspepsia on depression and somatosensory amplification","authors":"Meltem Pusuroglu, Bayram Kizilkaya","doi":"10.5455/medscience.2023.08.147","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.147","url":null,"abstract":"Helicobacter pylori gastritis is an infection frequently observed around the world. In our research, the effect of Helicobacter pylori positivity on depression and somatosensory amplification was investigated. The research included a total of 112 patients with dyspeptic complaints, 52 Helicobacter pylori positive and 60 Helicobacter pylori negative, and a healthy control group of 54 cases without any complaints. Participants completed the Beck Depression Inventory and the Somatosensory Amplification Scale. There was no effect of Helicobacter pylori positivity on depression levels (p=0.116), while Helicobacter pylori positivity had a significant effect on somatosensory amplification (F=6.794; p=0.010; η2=0.40). There were significant effects of dyspeptic complaints on depression levels (F=6.695; p=0.011; η2=0.039) and somatosensory amplification (F=7.554; p=0.007; η2=0.044). It was identified that somatosensory amplification, sex and family history were each statistically significant explanatory variables for depression (p=0.001 β2=0.255; p=0.038 β2=0.150; p=0.002 β2=0.230). There was a 0.269 increase in depression for each 1-unit increase in somatosensory amplification, the female sex increased depression by 2.463 units and positive family history increased it by 4.949 units. Helicobacter pylori positivity was not found to be a significant explanatory variable for depression (p=0.412). While Helicobacter pylori positivity did not have an effect on depression, it was found to be effective in somatosensory amplification. The presence of dyspeptic complaints was effective on both depression and somatosensory amplification. Somatosensory amplification was one of the factors predicting depression in patients with dyspeptic complaints. Somatosensory amplification is an important factor in patients with Helicobacter pylori positivity and dyspeptic complaints. Mental diseases should not be ignored during the monitoring and treatment of this patient group.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recently, as doctors and researchers investigate into to the possible benefits of daily diets, ketogenic diets (KD) have started to gain popularity. As the growing up popularity of KD in social media, researchers had the chance to show their academic studies to the public more easily. Therefore, in this study, KD is discussed in terms of the recently popular “altmetric analysis” by scientists. The aim of study is to highlight the role of the ketogenic diet, figure out the mechanism of ketone bodies and the pivotal role of altmetric studies in health sciences. In order to investigate the novel aspects of the top 100 (T100) most cited scientific research paper in academia, 100 most discussed research paper was selected on social media platforms about KD from 1992 to 2019 and it was compared in terms of bibliometrics in web of science and in terms of social media impact in altmetric.com. While the total citations of the top 100 articles ranged from 143–109, altmetric values of T100 are 0–1269. According to the top social media platforms where the articles are mentioned, Twitter, Facebook, and Patent are the most popular social media platforms, respectively. It was not always coherent how altmetric data related to traditional bibliometric analysis. Thus, it might be suggested that bibliometric and altmetric assessments be viewed as complementary to one another. And by far the most important result of this study is that the articles with the highest citation may not receive much attention on social media due to their subject content.
最近，随着医生和研究人员对日常饮食可能带来的好处进行调查，生酮饮食(KD)开始受到欢迎。随着KD在社交媒体上的普及，研究人员更容易向公众展示自己的学术研究成果。因此，在本研究中，KD是由科学家根据最近流行的“替代分析”来讨论的。研究的目的是强调生酮饮食的作用，揭示酮体的机制和替代研究在健康科学中的关键作用。为了探讨学术界被引次数最多的100篇科研论文的新颖性，选取了1992年至2019年社交媒体平台上关于KD的100篇讨论次数最多的研究论文，并对其在web of science上的文献计量学和altmetric.com上的社交媒体影响力进行了比较。前100篇文章的总被引次数在143-109之间，T100的替代度量值为0-1269。从文章被提及的社交媒体平台来看，Twitter、Facebook和Patent分别是最受欢迎的社交媒体平台。另类计量数据与传统文献计量分析的关系并不总是连贯的。因此，可以建议将文献计量学评价和替代计量学评价视为相互补充。到目前为止，这项研究最重要的结果是，被引用次数最高的文章可能由于其主题内容而在社交媒体上受到的关注并不多。
{"title":"A new approach to biochemistry: Bibliometric and altmetric analyses in the ketogenic diet","authors":"Busra Yusufoglu, Gokay Vardar, Gozde Kaya, Huseyin Yalcin","doi":"10.5455/medscience.2023.07.108","DOIUrl":"https://doi.org/10.5455/medscience.2023.07.108","url":null,"abstract":"Recently, as doctors and researchers investigate into to the possible benefits of daily diets, ketogenic diets (KD) have started to gain popularity. As the growing up popularity of KD in social media, researchers had the chance to show their academic studies to the public more easily. Therefore, in this study, KD is discussed in terms of the recently popular “altmetric analysis” by scientists. The aim of study is to highlight the role of the ketogenic diet, figure out the mechanism of ketone bodies and the pivotal role of altmetric studies in health sciences. In order to investigate the novel aspects of the top 100 (T100) most cited scientific research paper in academia, 100 most discussed research paper was selected on social media platforms about KD from 1992 to 2019 and it was compared in terms of bibliometrics in web of science and in terms of social media impact in altmetric.com. While the total citations of the top 100 articles ranged from 143–109, altmetric values of T100 are 0–1269. According to the top social media platforms where the articles are mentioned, Twitter, Facebook, and Patent are the most popular social media platforms, respectively. It was not always coherent how altmetric data related to traditional bibliometric analysis. Thus, it might be suggested that bibliometric and altmetric assessments be viewed as complementary to one another. And by far the most important result of this study is that the articles with the highest citation may not receive much attention on social media due to their subject content.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136205093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.08.126
Hilal Gumus
The aim of this study is to evaluate the stress distributions in the bone level, implant and prosthesis parts with three-dimensional (3D) finite element analysis (FEA) in treatment options obtained by using two implants in different positions and different diameters in the four missing maxillary incisors region. Four 3D FEA models were obtained simulating the human maxilla with anterior 4 missing teeth. It is an in vitro study evaluated only by performing FEA with a computer program. Model 1 (M1): 4.3mm diameter implant to 2 central incisors regions, Model 2 (M2): 4.3mm diameter implant to 2 lateral incisors regions, Model 3 (M3): 3.3mm diameter implant to 2 lateral incisors regions and Model 4 (M4): 4.3mm diameter implant to central incisor region, 3.3mm diameter to lateral incisor region. Titanium implants and titanium abutments were used. Four-unit monolithic zirconia cemented fixed partial prostheses were designed on them. An oblique force of 100N was applied to the cingulum of each tooth on the prosthesis at an angle of 45 degrees to the long axis. The data obtained by performing FEA on the stress values in the implants, prosthesis parts and bone were evaluated. Maximum and minimum principal stress in the bone tissue was observed most in model 3 and least in model 1. Von Mises values in the abutment, implant, screw and prosthesis were highest in model 3. According to the obtained stress values, it may be considered the best option to place a standard diameter implant where the central incisors are in the anterior region in order to reduce the stress on the bone. Treatment with a narrow-diameter implant with lateral incisors can be avoided.
本研究的目的是利用三维有限元分析(3D finite element analysis, FEA)评估在4个缺失的上颌切牙区域使用两种不同位置和不同直径的种植体获得的治疗方案在骨水平、种植体和修复体部位的应力分布。建立了4个模拟人前牙缺失上颌的三维有限元模型。这是一项体外研究，仅通过计算机程序进行有限元分析来评估。模型1 (M1):种植体直径4.3mm至2个中切牙区域，模型2 (M2):种植体直径4.3mm至2个侧切牙区域，模型3 (M3):种植体直径3.3mm至2个侧切牙区域，模型4 (M4):种植体直径4.3mm至中切牙区域，种植体直径3.3mm至侧切牙区域。采用钛种植体和钛基牙。在此基础上设计了四单元整体氧化锆骨水泥固定部分假体。对假体上每颗牙的带带以与长轴45度角施加100N的斜向力。通过有限元分析获得的数据对种植体、假体部分和骨的应力值进行评估。骨组织的最大和最小主应力在模型3中最大，在模型1中最小。模型3中基牙、种植体、螺钉和假体的Von Mises值最高。根据获得的应力值，可以考虑将标准直径种植体放置在中切牙位于前区的位置，以减少对骨的应力。可以避免侧切牙窄径种植体治疗。
{"title":"Evaluation of the stress distributions of the treatment options with 2 implants for 4 missing maxillary incisors with finite element analysis","authors":"Hilal Gumus","doi":"10.5455/medscience.2023.08.126","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.126","url":null,"abstract":"The aim of this study is to evaluate the stress distributions in the bone level, implant and prosthesis parts with three-dimensional (3D) finite element analysis (FEA) in treatment options obtained by using two implants in different positions and different diameters in the four missing maxillary incisors region. Four 3D FEA models were obtained simulating the human maxilla with anterior 4 missing teeth. It is an in vitro study evaluated only by performing FEA with a computer program. Model 1 (M1): 4.3mm diameter implant to 2 central incisors regions, Model 2 (M2): 4.3mm diameter implant to 2 lateral incisors regions, Model 3 (M3): 3.3mm diameter implant to 2 lateral incisors regions and Model 4 (M4): 4.3mm diameter implant to central incisor region, 3.3mm diameter to lateral incisor region. Titanium implants and titanium abutments were used. Four-unit monolithic zirconia cemented fixed partial prostheses were designed on them. An oblique force of 100N was applied to the cingulum of each tooth on the prosthesis at an angle of 45 degrees to the long axis. The data obtained by performing FEA on the stress values in the implants, prosthesis parts and bone were evaluated. Maximum and minimum principal stress in the bone tissue was observed most in model 3 and least in model 1. Von Mises values in the abutment, implant, screw and prosthesis were highest in model 3. According to the obtained stress values, it may be considered the best option to place a standard diameter implant where the central incisors are in the anterior region in order to reduce the stress on the bone. Treatment with a narrow-diameter implant with lateral incisors can be avoided.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135058853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic inflammation and oxidative stress can contribute to the development of cardiovascular diseases. Isoproterenol (ISO), a synthetic catecholamine, is used to study the effects of drugs on cardiotoxicity. Agmatine (AGM) is a type of biogenic amine produced through the decarboxylation of arginine. The purpose of the current study was to evaluate the effects of AGM against ISO-induced cardiotoxicity due to the described roles of AGM in cardiovascular disease. Four groups of thirty-two Wistar Albino rats were divided equally as control, ISO, AGM+ISO, and ISO+AGM. ISO was administered intraperitoneally (i.p.) twice at a dose of 150 mg/kg, at 24-hour intervals. Prior to and after ISO injection, 20 mg/kg of AGM was injected i.p. Hemodynamic measurements and serum and tissue biochemical analyses were evaluated at the end of the experiment. The levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) in the tissue were measured. In the ISO group, levels of lactate dehydrogenase (LDH) and creatine kinase (CK) were increased significantly (p<0.05). Co-administration of ISO and AGM significantly reduced CK and LDH levels (p<0.05). MDA levels increased in the ISO-treated group but decreased in the AGM-treated groups (p<0.05). Notably, there was a reduction in the CAT level in the ISO treatment group (p<0.05). CAT was found to be significantly increased (p<0.05) in the groups that received AGM compared to the ISO group. AGM+ISO group had a reduced density of degenerated cardiomyocytes and granulation tissue compared to the ISO group (p<0.05). Although granulation tissue demonstrated a significant reduction in the ISO+AGM group in comparison to the ISO group (p<0.05). In this study, the results indicate that AGM treatment can potentially inhibit ISO-induced myocardial injury and vascular dysfunction by preserving vascular integrity. Notably, the protective effects of AGM on cardiac damage appear to outweigh its therapeutic benefits, as shown by histopathological analysis
{"title":"The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats","authors":"Zeynep Ulutas, Semih Tapsiz, Onural Ozhan, Mehmet Sarihan, Azibe Yildiz, Merve Durhan, Nigar Vardi, Yilmaz Cigremis, Leyla Buyukkorkmaz, Hakan Parlakpinar","doi":"10.5455/medscience.2023.08.179","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.179","url":null,"abstract":"Chronic inflammation and oxidative stress can contribute to the development of cardiovascular diseases. Isoproterenol (ISO), a synthetic catecholamine, is used to study the effects of drugs on cardiotoxicity. Agmatine (AGM) is a type of biogenic amine produced through the decarboxylation of arginine. The purpose of the current study was to evaluate the effects of AGM against ISO-induced cardiotoxicity due to the described roles of AGM in cardiovascular disease. Four groups of thirty-two Wistar Albino rats were divided equally as control, ISO, AGM+ISO, and ISO+AGM. ISO was administered intraperitoneally (i.p.) twice at a dose of 150 mg/kg, at 24-hour intervals. Prior to and after ISO injection, 20 mg/kg of AGM was injected i.p. Hemodynamic measurements and serum and tissue biochemical analyses were evaluated at the end of the experiment. The levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) in the tissue were measured. In the ISO group, levels of lactate dehydrogenase (LDH) and creatine kinase (CK) were increased significantly (p<0.05). Co-administration of ISO and AGM significantly reduced CK and LDH levels (p<0.05). MDA levels increased in the ISO-treated group but decreased in the AGM-treated groups (p<0.05). Notably, there was a reduction in the CAT level in the ISO treatment group (p<0.05). CAT was found to be significantly increased (p<0.05) in the groups that received AGM compared to the ISO group. AGM+ISO group had a reduced density of degenerated cardiomyocytes and granulation tissue compared to the ISO group (p<0.05). Although granulation tissue demonstrated a significant reduction in the ISO+AGM group in comparison to the ISO group (p<0.05). In this study, the results indicate that AGM treatment can potentially inhibit ISO-induced myocardial injury and vascular dysfunction by preserving vascular integrity. Notably, the protective effects of AGM on cardiac damage appear to outweigh its therapeutic benefits, as shown by histopathological analysis","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135104934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.03.038
M. Aslan, Abdullah Gunes
{"title":"The role of breast cancer molecular subtypes in axillary lymph node positivity","authors":"M. Aslan, Abdullah Gunes","doi":"10.5455/medscience.2023.03.038","DOIUrl":"https://doi.org/10.5455/medscience.2023.03.038","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75567732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.01.013
B. Harma, T. Kıran, Feyza Inceoğlu
Pectus excavatum (PE) is the most common deformity among anterior chest wall abnormalities. Although many theories on the pathogenesis of PE have been described, the uncertainty is still going on whether it is a result of developmental, biochemical, or biomechanical reasons or their combination. The aim of this study was to evaluate the biochemical parameters that may cause or be associated with the development of PE between children with PE and their healthy peers. A total of 33 patients' medical records were retrospectively analyzed who followed up because of pectus excavatum between 2019 and 2021. A control group was formed from 32 healthy children from the hospital records with similar age and gender profiles as the patient group. The data from both groups were collected and statistically analyzed in terms of gender, age, and laboratory tests, including hemogram, Vit B12, Parathormone (PTH), Vit.D, Alkaline phosphatase (ALP), and serum Calcium (Ca) and Phosphor (P) levels. Compared to the control group, statistically, significantly higher serum ALP, P, and PTH levels with low Vit.B12 levels were detected. The significant difference in the levels of ALP, PTH, P, and Vit B12, which have an important place in the construction and development of osteochondral structures, may impair the remodeling capacity of the costosternal structure with the contribution of thoracic biomechanics. When PE deformity is noticed, if appropriate medical treatment such as vitamin and mineral supplements and diet regulation is applied to children in the follow-up process, the process can be slowed down, and the deformity can be alleviated.
{"title":"Some biochemical tips in the etiopathogenesis of Pectus Excavatum","authors":"B. Harma, T. Kıran, Feyza Inceoğlu","doi":"10.5455/medscience.2023.01.013","DOIUrl":"https://doi.org/10.5455/medscience.2023.01.013","url":null,"abstract":"Pectus excavatum (PE) is the most common deformity among anterior chest wall abnormalities. Although many theories on the pathogenesis of PE have been described, the uncertainty is still going on whether it is a result of developmental, biochemical, or biomechanical reasons or their combination. The aim of this study was to evaluate the biochemical parameters that may cause or be associated with the development of PE between children with PE and their healthy peers. A total of 33 patients' medical records were retrospectively analyzed who followed up because of pectus excavatum between 2019 and 2021. A control group was formed from 32 healthy children from the hospital records with similar age and gender profiles as the patient group. The data from both groups were collected and statistically analyzed in terms of gender, age, and laboratory tests, including hemogram, Vit B12, Parathormone (PTH), Vit.D, Alkaline phosphatase (ALP), and serum Calcium (Ca) and Phosphor (P) levels. Compared to the control group, statistically, significantly higher serum ALP, P, and PTH levels with low Vit.B12 levels were detected. The significant difference in the levels of ALP, PTH, P, and Vit B12, which have an important place in the construction and development of osteochondral structures, may impair the remodeling capacity of the costosternal structure with the contribution of thoracic biomechanics. When PE deformity is noticed, if appropriate medical treatment such as vitamin and mineral supplements and diet regulation is applied to children in the follow-up process, the process can be slowed down, and the deformity can be alleviated.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76240665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.07.105
D. Cengiz, Busra Kurtcu, Hanifi Korkmaz, S. Çolak, M. Aslan, M. Çiçek, S. Yılmaz
This study aims to evaluate the perception of anxiety, tinnitus, and noise sensitivity in liver transplant patients according to early and late periods following transplantation. The study included 76 patients with liver transplantation. They were divided into two groups according to the duration of time after transplantation: early (1-3 years) and late (5 years or more). A demographic data form, the Tinnitus Handicap Inventory (THI), Weinstein's Noise Sensitivity Scale (WNSS), and the Beck Anxiety Inventory (BAI) were administered and used for data collection. There was a statistically significant difference between the early and late-period groups in terms of WNSS and THI scores (p<0.05), whereas there was no statistically significant difference in BAI scores (p>0.05). Noise sensitivity and tinnitus perception of the late-period group were statistically higher than those of the early-period group (p<0.05). Correlations between BAI, WNSS, and THI scores of late-stage patients were significant (p<0.05). A multivariate regression model was performed with the WNSS and the THI as dependent variables. According to this analysis, the THI had a statistically significant positive effect on the BAI in the early period (p2=0.003) and WNSS had a statistically significant positive effect on the BAI score in the late period (p2=0.002). Both otologic and psychological effects are observed in patients with liver transplantation. The post-transplant period triggered otologic symptoms more. It is also noteworthy that psychological and otologic symptoms are in correlation. Psychological and otologic evaluations with a multidisciplinary approach should gain importance in the post-transplant period.
{"title":"An investigation of tinnitus, noise sensitivity and anxiety levels in liver transplantation patients in the early and late periods: A cross-sectional study","authors":"D. Cengiz, Busra Kurtcu, Hanifi Korkmaz, S. Çolak, M. Aslan, M. Çiçek, S. Yılmaz","doi":"10.5455/medscience.2023.07.105","DOIUrl":"https://doi.org/10.5455/medscience.2023.07.105","url":null,"abstract":"This study aims to evaluate the perception of anxiety, tinnitus, and noise sensitivity in liver transplant patients according to early and late periods following transplantation. The study included 76 patients with liver transplantation. They were divided into two groups according to the duration of time after transplantation: early (1-3 years) and late (5 years or more). A demographic data form, the Tinnitus Handicap Inventory (THI), Weinstein's Noise Sensitivity Scale (WNSS), and the Beck Anxiety Inventory (BAI) were administered and used for data collection. There was a statistically significant difference between the early and late-period groups in terms of WNSS and THI scores (p<0.05), whereas there was no statistically significant difference in BAI scores (p>0.05). Noise sensitivity and tinnitus perception of the late-period group were statistically higher than those of the early-period group (p<0.05). Correlations between BAI, WNSS, and THI scores of late-stage patients were significant (p<0.05). A multivariate regression model was performed with the WNSS and the THI as dependent variables. According to this analysis, the THI had a statistically significant positive effect on the BAI in the early period (p2=0.003) and WNSS had a statistically significant positive effect on the BAI score in the late period (p2=0.002). Both otologic and psychological effects are observed in patients with liver transplantation. The post-transplant period triggered otologic symptoms more. It is also noteworthy that psychological and otologic symptoms are in correlation. Psychological and otologic evaluations with a multidisciplinary approach should gain importance in the post-transplant period.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"248 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79520020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.02.027
Nasira Tiumonbaeva, A. Kazybekova, Kaliyman Kasymalieva, K. Soburov
Kyrgyzstan’s challenging natural conditions and fragile mountain ecosystems can weaken the immune system of individuals residing permanently in high-altitude areas. Our study aimed to explore specific immune protection indicators in healthy populations from the Chui and Naryn regions at varying mountain altitudes. We assessed percentages of CD3+ (T-lymphocytes), CD20+ (B-lymphocytes), CD4+ (T-helper lymphocytes), CD8+ (cytotoxic T-lymphocytes), IRI (immunoregulatory index), CIC (circulating immune complexes), and quantified immunoglobulins of classes A, M, and G. Using immunofluorescent methods and monoclonal antibodies; we determined the percentages of CD3+, CD20+, CD4+, and CD8+. Radial immunodiffusion was used to quantify immunoglobulins of classes A, M, and G, while Falk’s method helped study CIC levels in blood sera. The participant count was based on statistical expert recommendations and G power analysis. The analysis revealed a decrease in the total number of T-lymphocytes (CD3+), primarily due to reduced T-helper and cytotoxic T-lymphocyte subpopulations. However, a significant increase in cytotoxic T-lymphocytes (CD8+) was observed among high-altitude residents. Mountain residents exhibited wide-ranging individual fluctuations for each immunoglobulin class. Our findings suggest varying degrees of immune mechanism disruptions, which maintain natural protection and internal environment constancy at different altitudes, resulting in a mixed type of cellular and humoral immunity suppression. These results emphasize the need for further research in the region and consideration of altitude when implementing disease prevention strategies related to the immune system for the local population.
{"title":"Regional peculiarities of specific immunity in inhabitants of different mountain heights of the Kyrgyz Republic","authors":"Nasira Tiumonbaeva, A. Kazybekova, Kaliyman Kasymalieva, K. Soburov","doi":"10.5455/medscience.2023.02.027","DOIUrl":"https://doi.org/10.5455/medscience.2023.02.027","url":null,"abstract":"Kyrgyzstan’s challenging natural conditions and fragile mountain ecosystems can weaken the immune system of individuals residing permanently in high-altitude areas. Our study aimed to explore specific immune protection indicators in healthy populations from the Chui and Naryn regions at varying mountain altitudes. We assessed percentages of CD3+ (T-lymphocytes), CD20+ (B-lymphocytes), CD4+ (T-helper lymphocytes), CD8+ (cytotoxic T-lymphocytes), IRI (immunoregulatory index), CIC (circulating immune complexes), and quantified immunoglobulins of classes A, M, and G. Using immunofluorescent methods and monoclonal antibodies; we determined the percentages of CD3+, CD20+, CD4+, and CD8+. Radial immunodiffusion was used to quantify immunoglobulins of classes A, M, and G, while Falk’s method helped study CIC levels in blood sera. The participant count was based on statistical expert recommendations and G power analysis. The analysis revealed a decrease in the total number of T-lymphocytes (CD3+), primarily due to reduced T-helper and cytotoxic T-lymphocyte subpopulations. However, a significant increase in cytotoxic T-lymphocytes (CD8+) was observed among high-altitude residents. Mountain residents exhibited wide-ranging individual fluctuations for each immunoglobulin class. Our findings suggest varying degrees of immune mechanism disruptions, which maintain natural protection and internal environment constancy at different altitudes, resulting in a mixed type of cellular and humoral immunity suppression. These results emphasize the need for further research in the region and consideration of altitude when implementing disease prevention strategies related to the immune system for the local population.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84385883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.05.073
M. Koroglu, M. Karakaplan, E. Ergen, Enes Gunduz, H. Ozdes, O. Aslanturk
Pediatric femur diaphyseal fractures are seen after serious traumas such as traffic accidents and fall from height. Although treatment algorithms are made according to age groups, treatment planning is individualized according to the patient and the degree of injury. In our study, we evaluated functional outcomes of pediatric femur fractures treated with titanium elastic nail (TEN). This is a retrospective study including pediatric femoral diaphyseal fractures treated with TEN between 2012 and 2021. Open fractures, pathological fractures, distal fractures involving the femoral condyles, and proximal fractures involving the trochanteric region were not included in our study. Thirty-three femoral diaphyseal fractures with complete data were identified as stable and unstable in length, and functional results and post-treatment complications were recorded by performing TEN in fracture fixation. Clinical functional results were analyzed with Flynn criteria. Thirty-three femoral fractures of 29 patients were included. Eighteen (62.1%) of our patients were boys and 11 (37.9%) were girls. The mean age was 6.51 years (4-13 years). The most common injury mechanism was traffic accidents seen in 19 patients (24.51%). The mean follow-up period after surgery was 26.6 (6-90 months) months. Stable fractures (transverse and short oblique) were found in 26 cases (78.7%) and unstable fractures (spiral/long oblique and comminuted) in 7 cases (21.7%). According to Flynn criteria, excellent results were found in 20 fractures (60.6%) and satisfactory results in 10 fractures (30.3%) and 3 poor (%9.09). There was no significant difference between stable and unstable fractures in terms of functional outcome (p=0.12). Femoral diaphyseal fractures are serious injuries that require surgery. Regardless of the type of fracture, stable or unstable in length, the results of treatment with TEN are very successful. Major complications such as nonunion and re-fracture are rarely seen with this treatment.
{"title":"Functional outcomes of titanium elastic nail procedure after femoral shaft fracture in pediatric patients","authors":"M. Koroglu, M. Karakaplan, E. Ergen, Enes Gunduz, H. Ozdes, O. Aslanturk","doi":"10.5455/medscience.2023.05.073","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.073","url":null,"abstract":"Pediatric femur diaphyseal fractures are seen after serious traumas such as traffic accidents and fall from height. Although treatment algorithms are made according to age groups, treatment planning is individualized according to the patient and the degree of injury. In our study, we evaluated functional outcomes of pediatric femur fractures treated with titanium elastic nail (TEN). This is a retrospective study including pediatric femoral diaphyseal fractures treated with TEN between 2012 and 2021. Open fractures, pathological fractures, distal fractures involving the femoral condyles, and proximal fractures involving the trochanteric region were not included in our study. Thirty-three femoral diaphyseal fractures with complete data were identified as stable and unstable in length, and functional results and post-treatment complications were recorded by performing TEN in fracture fixation. Clinical functional results were analyzed with Flynn criteria. Thirty-three femoral fractures of 29 patients were included. Eighteen (62.1%) of our patients were boys and 11 (37.9%) were girls. The mean age was 6.51 years (4-13 years). The most common injury mechanism was traffic accidents seen in 19 patients (24.51%). The mean follow-up period after surgery was 26.6 (6-90 months) months. Stable fractures (transverse and short oblique) were found in 26 cases (78.7%) and unstable fractures (spiral/long oblique and comminuted) in 7 cases (21.7%). According to Flynn criteria, excellent results were found in 20 fractures (60.6%) and satisfactory results in 10 fractures (30.3%) and 3 poor (%9.09). There was no significant difference between stable and unstable fractures in terms of functional outcome (p=0.12). Femoral diaphyseal fractures are serious injuries that require surgery. Regardless of the type of fracture, stable or unstable in length, the results of treatment with TEN are very successful. Major complications such as nonunion and re-fracture are rarely seen with this treatment.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84524772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.01.06
Esra Guney, E. Okyay
The study was aim to determine the effect of personality and sociodemographic characteristics on the avoidance of pregnancy by nulliparous women. The cross-sectional study was conducted through nullipar women's groups on social media platforms (Instagram, Facebook Messenger and WhatsApp etc.). 602 women who volunteered to fill out the questionnaire participated in the study, whose sample consisted of women who had not given birth before, and the study data were collected in November 2022. Data collection forms were created using the Google forms application. Personal Information Form, Ten-Item Personality Inventory (TIPI), and Desire to Avoid Pregnancy (DAP) were used to collect the data. Mean, percentile distribution, standard deviation, t test, one-way ANOVA and simple linear regression analysis were used for statistical analysis. In the study, it was determined that those who were 21 years of age and under, those with a high education level, those who were not working, those who did not think about giving birth, and those who planned a cesarean delivery in the future had higher pregnancy avoidance scores (p<0.05). The simple linear regression model showed that age, education level, future pregnancy planning status, planned future birth, openness to experiences and conscientiousness personality traits are important determinants of the desire to avoid pregnancy in women (respectively β=-.0.379; β=0.118; β=-0.345; β=0.107; β=0.202; β=0.203; p<0.001 for all; p<0.05 for birth planned in the future only). Pregnancy avoidance can be seen in nulliparous women who are 21 years of age or younger, have a high level of education, are not working, do not think about giving birth, have a low desire to conceive in the future, plan a future cesarean section, have openness to experiences and conscientiousness personality traits.
{"title":"Desire avoid of pregnancy in nulliparous women: The effect of personality and sociodemographic characteristics","authors":"Esra Guney, E. Okyay","doi":"10.5455/medscience.2023.01.06","DOIUrl":"https://doi.org/10.5455/medscience.2023.01.06","url":null,"abstract":"The study was aim to determine the effect of personality and sociodemographic characteristics on the avoidance of pregnancy by nulliparous women. The cross-sectional study was conducted through nullipar women's groups on social media platforms (Instagram, Facebook Messenger and WhatsApp etc.). 602 women who volunteered to fill out the questionnaire participated in the study, whose sample consisted of women who had not given birth before, and the study data were collected in November 2022. Data collection forms were created using the Google forms application. Personal Information Form, Ten-Item Personality Inventory (TIPI), and Desire to Avoid Pregnancy (DAP) were used to collect the data. Mean, percentile distribution, standard deviation, t test, one-way ANOVA and simple linear regression analysis were used for statistical analysis. In the study, it was determined that those who were 21 years of age and under, those with a high education level, those who were not working, those who did not think about giving birth, and those who planned a cesarean delivery in the future had higher pregnancy avoidance scores (p<0.05). The simple linear regression model showed that age, education level, future pregnancy planning status, planned future birth, openness to experiences and conscientiousness personality traits are important determinants of the desire to avoid pregnancy in women (respectively β=-.0.379; β=0.118; β=-0.345; β=0.107; β=0.202; β=0.203; p<0.001 for all; p<0.05 for birth planned in the future only). Pregnancy avoidance can be seen in nulliparous women who are 21 years of age or younger, have a high level of education, are not working, do not think about giving birth, have a low desire to conceive in the future, plan a future cesarean section, have openness to experiences and conscientiousness personality traits.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84636936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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