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Exploring therapeutic potential of plga nanoparticles in oncotherapeutics plga纳米颗粒在肿瘤治疗中的治疗潜力探索
Q3 Engineering Pub Date : 2022-05-04 DOI: 10.2174/1876402914666220504143153
L R Amruth Kumar
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引用次数: 0
The Investigation of Carrier Mobility Effect on the Performance Characteristics of the InGaN-Based Vertical Cavity Surface Emitting Laser (VCSEL) by Solving the Rate Equations 通过求解速率方程研究载流子迁移率对基于ingan的垂直腔面发射激光器性能特性的影响
Q3 Engineering Pub Date : 2022-03-30 DOI: 10.2174/1876402914666220330014428
A. Z. Goharrizi, G. Alahyarizadeh
Among the parameters that play an important role in describing the performance of many devices is carrier mobility which is a criterion for the easy movement in semiconductor crystals.The effect of carrier mobility on the performance characteristics of InGaN quantum well vertical cavity surface-emitting laser was analytically investigated.By solving the Poisson’s equation, current density equation, charge concentration continuity equation and carrier and photon rate equations, the variation of current density and carrier density with respect to the position and time and the effects of carrier mobility and temperature on these parameters were investigated. Furthermore, the effect of mobility on the variation of output power versus the injection current and on the time variation of photon and carrier density and output power was investigated.By increasing the carrier mobility, the threshold current reduced and the output power increased. In studying the effect of temperature on the desired parameters, the variation of carrier density with respect to time and position was affected by the temperature change. This phenomenon is due to the dependence of these parameters on the diffusion coefficients and consequently on the mobility of the carriers and the dependence of mobility on temperature.The threshold current was reduced when the electron mobility rises due to the increased accumulation of carriers and consequently the increase of carrier recombination. The output power increased, and the time delay to accrue the laser decreased. Consequently, the carrier recombination increased, further resulting in a rapid laser operation.
在描述许多器件性能中起重要作用的参数之一是载流子迁移率,这是半导体晶体中容易移动的标准。分析研究了载流子迁移率对InGaN量子阱垂直腔面发射激光器性能的影响。通过求解泊松方程、电流密度方程、电荷浓度连续性方程以及载流子和光子速率方程,研究了电流密度和载流子密度随位置和时间的变化以及载流子迁移率和温度对这些参数的影响。此外,还研究了迁移率对输出功率随注入电流变化的影响,以及对光子、载流子密度和输出功率随时间变化的影响。通过增加载流子迁移率,阈值电流减小,输出功率增加。在研究温度对所需参数的影响时,载流子密度随时间和位置的变化受到温度变化的影响。这种现象是由于这些参数对扩散系数的依赖性,因此对载流子的迁移率的依赖性以及迁移率对温度的依赖性。当电子迁移率上升时,由于载流子的积累增加以及载流子复合的增加,阈值电流减小。输出功率增加,并且积累激光的时间延迟减小。因此,载流子复合增加,进一步导致快速的激光操作。
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引用次数: 0
Optical Tree Net (OTN) Logic Circuits Using Mechanical Movable Mirrors 使用机械可移动反射镜的光树网(OTN)逻辑电路
Q3 Engineering Pub Date : 2022-03-30 DOI: 10.2174/1876402914666220330125417
T. Chattopadhyay, Dilip Kumar Gayen
Utilizing mirror movement precisely, one can undoubtedly make the diverse way for light. The movable mirror can be placed in the path of an optical tree net to perform different operations.In this paper, we have performed different logic, arithmetic and one-bit data comparison operations using mechanical movable mirrors.Using two controls with three movable mirrors and two fixed mirrors, we can perform four basic logic operations. Then using these four basic operations, we can design sixteen different logic operations, half adder and one-bit data comparison operations.Because of the component of an adaptable mirror arranging and course, expansion incidents can be decreased to an incredibly low level. The necessary voltage is under 0.5 V. The power utilization is about 3.5 mW for an exchanging component.Moreover, this plan is extremely straightforward in senseand designed using linear optical materials. The principle of operation of this circuit is based on the reflection of light from MEMS-based optical switches.
准确地利用镜面运动,无疑可以创造出多样化的光路。可移动反射镜可以放置在光学树网的路径中以执行不同的操作。在本文中,我们使用机械可移动反射镜执行了不同的逻辑、算术和一位数据比较操作。使用带有三个可移动反射镜和两个固定反射镜的两个控件,我们可以执行四个基本逻辑操作。然后使用这四个基本运算,我们可以设计十六种不同的逻辑运算、半加法器和一位数据比较运算。由于有了可调整的镜子排列和路线,扩展事件可以减少到令人难以置信的低水平。所需电压低于0.5V。对于交换部件,功率利用率约为3.5mW。此外,该方案在感官上非常简单,并使用线性光学材料进行设计。该电路的工作原理基于来自基于MEMS的光学开关的光的反射。
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引用次数: 0
Hybrid Model-Based and Data-Driven Solution for Uncertainty Quantification at the Microscale 基于模型和数据驱动的微尺度不确定度量化混合解决方案
Q3 Engineering Pub Date : 2022-03-28 DOI: 10.2174/1876402914666220328123601
J. P. Quesada-Molina, S. Mariani
Due to their size, Micro Electromechanical Systems (MEMS) display performance indices affected by uncertainties linked to the mechanical properties and to the geometry of the films constituting their movable parts.In this perspective, a recently proposed multiscale and hybrid solution for uncertainty quantification is discussed.The proposed method is based on the (deep) learning of the morphology-affected elasticity of the polycrystalline films, and of the microfabrication-induced defective geometry of the devices. The results at the material and at the device levels are linked through a reduced-order representation of the response of the entire device to the external stimuli, foressen to finally feed a Monte Carlo uncertainty quantification engine.Preliminary results relevant to a single-axis resonant Lorentz force micro-magnetometer have shown a noteworthy capability of the proposed multiscale deep learning method to account for the mentioned uncertainty sources at the microscale.A promising two-scale deep learning approach has been proposed for polysilicon MEMS sensors to account for both materials- and geometry-governed uncertainties, and to properly describe the scale-dependent response of MEMS devices.
由于其尺寸,微机电系统(MEMS)显示的性能指标受到与机械性能和构成其可移动部件的薄膜几何形状相关的不确定性的影响。从这个角度出发,本文讨论了最近提出的一种多尺度混合不确定性量化方法。所提出的方法是基于(深度)学习形貌影响的多晶薄膜弹性,以及微加工引起的器件几何缺陷。材料和设备层面的结果通过整个设备对外部刺激的响应的降阶表示相关联,最终输入蒙特卡罗不确定性量化引擎。与单轴谐振洛伦兹力微磁力计相关的初步结果表明,所提出的多尺度深度学习方法具有显著的能力,可以在微尺度上解释上述不确定性源。针对多晶硅MEMS传感器提出了一种有前途的双尺度深度学习方法,以考虑材料和几何控制的不确定性,并正确描述MEMS器件的尺度相关响应。
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引用次数: 2
Nanostructured Material and Its Application in Membrane Separation Technology 纳米结构材料及其在膜分离技术中的应用
Q3 Engineering Pub Date : 2022-03-18 DOI: 10.2174/1876402914666220318121343
Tugrul Talha Ersoz, M. Ersoz
Nanomaterials are classified with their at least one dimension in the range of 1-100 nm, which offers new innovative solutions for membrane development. These are included as nanosized adsorbents, nanomembranes, nanocomposites, photocatalysts, nanotubes, nanoclays, etc. Nanomaterials are promising, exceptional properties for one of the opportunity is to prevent the global water crisis with their extraordinary performance as their usage for membrane development, particularly for water treatment process. Nanomaterial based membranes that include nanoparticles, nanofibers, 2D layered materials, and their nanostructured composites which provide superior permeation characteristics besides their antifouling, antibacterial and photodegradation properties. They are enable for providing the extraordinary properties to be used as ultrafast and ultimately selective membranes for water purification. In this review, recently developed nanomaterial based membranes and their applications for water treatment process were summarized. The main attention is given to the nanomaterial based membrane structure design. The variety in terms of constituent structure and alterations provide nanomaterial based membranes which will be expected to be a perfect separation membrane in the future.
纳米材料在1-100纳米范围内至少有一个维度,这为膜的开发提供了新的创新解决方案。这些材料包括纳米吸附剂、纳米膜、纳米复合材料、光催化剂、纳米管、纳米粘土等。纳米材料是很有前途的,特殊的性能,其中一个机会是防止全球水危机,因为它们的非凡性能被用于膜的开发,特别是水处理过程。基于纳米材料的膜,包括纳米颗粒、纳米纤维、二维层状材料及其纳米结构复合材料,除了具有防污、抗菌和光降解特性外,还具有优越的渗透特性。它们能够提供非凡的性能,用作超快和最终选择性的水净化膜。本文综述了近年来纳米基膜及其在水处理工艺中的应用。本文主要关注基于纳米材料的膜结构设计。纳米材料在组成结构和变化方面的多样性提供了纳米基膜,有望在未来成为一种完美的分离膜。
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引用次数: 0
Recent Applications and Synthesis Techniques of Graphene 石墨烯的最新应用和合成技术
Q3 Engineering Pub Date : 2022-03-18 DOI: 10.2174/1876402914666220318111303
M. Makwana, Ajay M. Patel
Graphene's mass and low-cost production has become an essential step toward its real-world applications, due to significant advancements in fundamental research and industrial applications. Graphene, a one-atom thick carbon crystal with a unique set of physical and chemical properties comprising from extreme mechanical behaviour with excellent electrical and thermal conductivity, is emerging as a serious contender to replace many traditional materials in a variety of applications. Graphene has the potential to improve the performance, functionality, and durability of a broad spectrum of applications, but its commercialization will require more study. Applications and emerging techniques for the production of graphene have been investigated in this study. To increase the use of graphene, its current limitations must be solved expeditiously to improve its current performance. In terms of applications, graphene's advantages have expanded its use in both electroanalytical and electrochemical sensors. The most relevant experimental achievements on the fabrication of graphene material, as well as its evolving features in relation to smart applications, are highlighted in this review study. We explore how graphene may be successfully integrated directly into devices, enabling a wide range of applications such as transparent electrodes, photovoltaics, thermoelectricity, 3D printing, and applications in biomedical and bioimaging devices. Graphene's prospects are also explored and discussed.
由于基础研究和工业应用的重大进展,石墨烯的大规模低成本生产已成为其在现实世界中应用的重要一步。石墨烯是一种单原子厚的碳晶体,具有一系列独特的物理和化学性质,包括具有优异导电性和导热性的极端机械性能,正成为在各种应用中取代许多传统材料的有力竞争者。石墨烯有潜力提高广泛应用的性能、功能和耐用性,但其商业化还需要更多的研究。本研究对石墨烯生产的应用和新兴技术进行了研究。为了增加石墨烯的使用,必须迅速解决其电流限制,以提高其电流性能。在应用方面,石墨烯的优势扩大了其在电分析和电化学传感器中的应用。本综述研究重点介绍了石墨烯材料制备方面最相关的实验成果,以及其在智能应用方面的发展特点。我们探索了石墨烯如何成功地直接集成到设备中,从而实现广泛的应用,如透明电极、光伏、热电、3D打印,以及在生物医学和生物成像设备中的应用。并对石墨烯的发展前景进行了探讨。
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引用次数: 3
M-estimation based robust approach for hybrid dynamic state estimation in power systems 基于m估计的电力系统混合动态估计鲁棒方法
Q3 Engineering Pub Date : 2022-02-25 DOI: 10.2174/1876402914666220225161505
S. Kundu, M. Alam, Biman Kumar Saha Roy3, S. S. Thakur
The state estimation (SE) process in power systems estimates bus voltage magnitude and phase angles vital for operating the system securely and reliably. The power systems state estimation problem has been extensively solved through weighted least squares (WLS) based static approach that fails to track the system dynamics properly. Furthermore, those approaches are not inherently robust against outliers, yielding a separate bad data processing (BDP) technique. Popular Dynamic state estimation (DSE) schemes which mainly employ nonlinear Kalman filters like Extended Kalman Filter (EKF) and Unscented Kalman Filter (UKF), also suffer from providing a reasonable estimation of states in the presence of bad data. Although several generalized maximum (GM) likelihood-based DSE approaches are robust against outliers, they are mainly based on nonlinear Kalman filters, which yield an iterative process. Therefore, this article focuses on developing a robust DSE approach that gives a good estimation of states against outliers in a single iteration.This article aims to propose a robust hybrid non-iterative DSE approach that gives robust SE results in the presence of bad data.The proposed novel robust hybrid DSE (NRHDSE) approach combines the robust M-estimation with the original novel hybrid DSE (NHDSE) approach. The proposed scheme implements a suitable linear relationship between integrated hybrid measurements and complex states. The proposed method uses a linear measurement model and thus employs an optimal linear Kalman filter to correct or estimate states.The efficacy of the proposed approach has been demonstrated by applying it on IEEE 57, 118 bus test systems and one more extensive 246 Indian utility bus system namely, Northern Regional Power Grid (NRPG), and after that comparing it with the original NHDSE, and DSE methods based on traditional EKF and M-estimation based robust version of EKF (REKF). The simulation result demonstrates the superiority of the proposed approach.Obtained results clearly show the superiority of the proposed approach.
电力系统中的状态估计(SE)过程估计对系统安全可靠运行至关重要的母线电压幅值和相位角。基于加权最小二乘法(WLS)的静态方法未能正确跟踪系统动态,已广泛解决了电力系统状态估计问题。此外,这些方法对异常值并不是固有的鲁棒性,从而产生了一种单独的不良数据处理(BDP)技术。流行的动态状态估计(DSE)方案主要采用非线性卡尔曼滤波器,如扩展卡尔曼滤波器(EKF)和无迹卡尔曼滤波器(UKF),在存在不良数据的情况下也难以提供合理的状态估计。尽管几种基于广义最大似然(GM)的DSE方法对异常值具有鲁棒性,但它们主要基于非线性卡尔曼滤波器,这会产生迭代过程。因此,本文侧重于开发一种稳健的DSE方法,该方法可以在一次迭代中针对异常值对状态进行良好的估计。本文旨在提出一种稳健的混合非迭代DSE方法,该方法在存在坏数据的情况下提供稳健的SE结果。所提出的新的鲁棒混合DSE(NRHDSE)方法将鲁棒M-估计与原始的新的混合DSE方法(NHDSE)相结合。所提出的方案实现了集成混合测量和复杂状态之间的适当线性关系。所提出的方法使用线性测量模型,从而使用最优线性卡尔曼滤波器来校正或估计状态。通过将所提出的方法应用于IEEE 57/118总线测试系统和一个更广泛的246印度公用事业总线系统,即北方地区电网(NRPG),并将其与原始的NHDSE以及基于传统EKF和基于M估计的稳健版EKF(REKF)的DSE方法进行比较,已经证明了该方法的有效性。仿真结果表明了该方法的优越性。所获得的结果清楚地表明了所提出的方法的优越性。
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引用次数: 0
Transdermal patches approach towards self nano emulsifying drug delivery system (snedds) using essential oil as penetration enhancer 使用精油作为渗透促进剂的自纳米乳化药物递送系统(snedds)的透皮贴剂方法
Q3 Engineering Pub Date : 2022-02-21 DOI: 10.2174/1876402914666220221105304
H. Farooqui, S. Upadhyay, P. Upadhyay
A transdermal patch is a topically applied dosed adhesive patch that delivers a medication dose directly into the blood. The patch allows for the safe delivery of a drug to the targeted site, ideally by a permeable layer covering a reservoir of the drug by melting small patches of drug embedded in the adhesive, which is one benefit of transdermal drug delivery over most types of pharmaceutical deliveries including oral, topical, intramuscular, intravenous, and several others. This can also help in the healing of a damaged body part, to improve patient compliance, treatment efficacy, and dose frequency while minimizing side effects. This review covers the production, methods of evaluation, qualities, use of penetration enhancers, and pros and downsides of Transdermal patches, as well as the benefits of essential oil as a penetration enhancer. Compared to chemical enhancers, essential oils have shown the ability to break down the stratum corneum layer, allowing drugs to penetrate deeper into the skin. Essential oils are excellent penetration enhancers for the skin. These penetration enhancers are cost-effective, biocompatible, readily available, non-toxic, chemically modifiable, and possibly biodegradable. In this review, attention has been drawn towards the formulation and evaluation of transdermal patches with the help and applications of SNEDDS (Self Nano Emulsifying Drug Delivery System) using essential oil as a penetration enhancer and their future prospective.
透皮贴片是一种局部应用的贴片,可将药物剂量直接输送到血液中。该贴片允许将药物安全递送到目标部位,理想情况下,通过融化嵌入在粘合剂中的小片药物,覆盖药物储库的可渗透层,这是透皮药物递送比大多数类型的药物递送(包括口服,局部,肌肉注射,静脉注射等)的一个好处。这也有助于身体受损部位的愈合,提高患者的依从性,治疗效果和剂量频率,同时最大限度地减少副作用。本文综述了透皮贴剂的生产、评价方法、质量、渗透促进剂的使用、优缺点以及精油作为渗透促进剂的好处。与化学增强剂相比,精油已经显示出分解角质层的能力,使药物能够深入皮肤。精油是极好的皮肤渗透增强剂。这些渗透增强剂具有成本效益高、生物相容性好、易得、无毒、可化学修饰且可能可生物降解的特点。本文综述了以精油为渗透促进剂的自纳米乳化给药系统(SNEDDS)的制备、评价、应用及其前景。
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引用次数: 1
Squeeze-film damping of microbeam and microplate resonators in the free molecular regime 自由分子状态下微束和微板谐振器的挤压膜阻尼
Q3 Engineering Pub Date : 2022-02-21 DOI: 10.2174/1876402914666220221113221
Zhaodong Wang, Pu Li, Beibei Sun
Correct modeling of squeeze-film damping (SFD) is an important consideration in the design of high-Q microresonators. In 2002, using the molecular dynamics (MD) approach, Bao et al. developed an analytical MD model for the evaluation of the SFD of a parallel-plate device in the free molecular regime. Their model was based on the energy exchange between the oscillating plate and gas molecules. Bao’s model is now widely used in microsystem design. However, Bao’s model cannot reduce to the air damping model in free space and is unsuitable for flexible microbeams.This paper first presents a more accurate analytical model for the evaluation of the SFD of the parallel plate. Then the present analytical model is extended to model the SFD of flexible microbeams with deformed shapes.This paper is based on the momentum transfer between the vibration plate and gas molecules. Results: The analytical results of the present model have shown a good agreement with the available experimental results.The limitations in the previous model are overcome.
在高q微谐振器的设计中,正确建模挤压膜阻尼是一个重要的考虑因素。2002年,Bao等人利用分子动力学(MD)方法开发了一种分析MD模型,用于评估自由分子状态下平行板装置的SFD。他们的模型是基于振动板和气体分子之间的能量交换。鲍的模型现在被广泛应用于微系统设计。然而,Bao的模型不能简化为自由空间的空气阻尼模型,不适合柔性微梁。本文首先提出了一种较为精确的分析模型来评估平行板的SFD。然后,将该解析模型推广到具有变形形状的柔性微梁的SFD模型。本文基于振动板与气体分子之间的动量传递。结果:模型的分析结果与已有的实验结果吻合较好。克服了以前模型的局限性。
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引用次数: 0
Performance Analysis of 6T SRAM and ONOFIC Cells 6T SRAM和ONOFIC电池的性能分析
Q3 Engineering Pub Date : 2021-12-02 DOI: 10.2174/1876402913666211202114736
V. Sharma, Masood Ahmad Malik
As the Technology node scales down to deep sub-micron regime, the design of static random-access memory (SRAM) cell becomes a critical issue because of increased leakage current components. These leakage current components prevent to design a low power processor as large of the processor power is consumed by the memory part. In this paper, a SRAM cell is designed based on ON/OFF logic (ONOFIC) approach. Static noise margin (SNM) of the cell for the different states are calculated and evaluated by using butterfly as well as noise (N) curves with the help of Cadence tools at 45 nm technology node.ONOFIC approach helps to reduce the leakage current components which makes a low power memory cell. A performance comparison is made between the conventional six-transistor (6T) SRAM cell and memory cell using ONOFIC approach. Low value of power delay product (PDP) is the outcome of ONOFIC approach as compared to conventional cell. ONOFIC approach decreases PDP by 99.99% in case of hold state. ONOFIC approach improves the different performance metrics for the different states of the SRAM cell.
随着技术节点缩小到深亚微米范围,由于泄漏电流元件的增加,静态随机存取存储器(SRAM)单元的设计成为一个关键问题。这些漏电流元件阻碍了低功耗处理器的设计,因为处理器的大部分功率被存储部分消耗。本文设计了一个基于on /OFF逻辑(ONOFIC)方法的SRAM单元。在45 nm技术节点,借助Cadence工具,利用蝴蝶曲线和噪声(N)曲线计算和评价了细胞在不同状态下的静态噪声裕度(SNM)。ONOFIC方法有助于减少组件的漏电流,从而使低功耗存储单元。对传统的六晶体管SRAM单元和采用ONOFIC方法的存储单元进行了性能比较。与传统蜂窝相比,ONOFIC方法具有较低的功率延迟积(PDP)值。ONOFIC进近在保持状态下使PDP降低99.99%。ONOFIC方法针对SRAM单元的不同状态提高了不同的性能指标。
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引用次数: 1
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Micro and Nanosystems
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