Farida Hussein El Rashedy, S. Ragab, Ashraf Abd El-Fatah Dawood, R. A. E. El Ashmawy, M. E. El Hawy
Objectives : To evaluate pentraxin-3 (PTX-3) levels in pediatric patients with b -thalassemia major, intermedia, and minor and its relationship with antioxidant capacity and total oxidant stress. Background : PTX-3 increases alongside with oxidant stress. Therefore, it can be used as an early diagnostic marker for in fl ammation. Patients and methods : A case e control study was conducted on 60 pediatric patients with b -thalassemia enrolled from the Pediatric Department of Menou fi a University. In addition, 30 age-matched and sex-matched healthy children were included as a control group. The study was performed during January 2020 to January 2022. Results : PTX-3 level was higher in all patients with b -thalassemia compared with control. The total antioxidant capacity was signi fi cantly lower in patients with b -thalassemia major versus b -thalassemia intermedia and minor. The cutoff value to detect b -thalassemia major in pediatric patients was 2.15 ng/ml, with an area under the curve of 0.846, with sensitivity and speci fi city of 93.3 and 63.3%, respectively. Moreover, the cutoff value for total antioxidant capacity was 2.11 nmol/well, with area under the curve of 0.695, with sensitivity and speci fi city of 86.5 and 71.5%, respectively, in relation to serum ferritin for detection of risky oxidative stress in patients with b -thalassemia. Conclusion : PTX-3 level was higher in all b -thalassemia groups compared to control. So it could be used as a marker for b -thalassemia diagnosis. Moreover, total antioxidant capacity was signi fi cantly lower in patients with b -thalassemia major versus b -thalassemia intermedia and minor, which could be used as a speci fi c test for differentiation.
{"title":"Pentraxin-3 Levels in Β-thalassemia Major and its Relationship with Antioxidant Capacity and Total Oxidant Stress","authors":"Farida Hussein El Rashedy, S. Ragab, Ashraf Abd El-Fatah Dawood, R. A. E. El Ashmawy, M. E. El Hawy","doi":"10.59204/2314-6788.1019","DOIUrl":"https://doi.org/10.59204/2314-6788.1019","url":null,"abstract":"Objectives : To evaluate pentraxin-3 (PTX-3) levels in pediatric patients with b -thalassemia major, intermedia, and minor and its relationship with antioxidant capacity and total oxidant stress. Background : PTX-3 increases alongside with oxidant stress. Therefore, it can be used as an early diagnostic marker for in fl ammation. Patients and methods : A case e control study was conducted on 60 pediatric patients with b -thalassemia enrolled from the Pediatric Department of Menou fi a University. In addition, 30 age-matched and sex-matched healthy children were included as a control group. The study was performed during January 2020 to January 2022. Results : PTX-3 level was higher in all patients with b -thalassemia compared with control. The total antioxidant capacity was signi fi cantly lower in patients with b -thalassemia major versus b -thalassemia intermedia and minor. The cutoff value to detect b -thalassemia major in pediatric patients was 2.15 ng/ml, with an area under the curve of 0.846, with sensitivity and speci fi city of 93.3 and 63.3%, respectively. Moreover, the cutoff value for total antioxidant capacity was 2.11 nmol/well, with area under the curve of 0.695, with sensitivity and speci fi city of 86.5 and 71.5%, respectively, in relation to serum ferritin for detection of risky oxidative stress in patients with b -thalassemia. Conclusion : PTX-3 level was higher in all b -thalassemia groups compared to control. So it could be used as a marker for b -thalassemia diagnosis. Moreover, total antioxidant capacity was signi fi cantly lower in patients with b -thalassemia major versus b -thalassemia intermedia and minor, which could be used as a speci fi c test for differentiation.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79335024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives Evaluation of treatment of type-I retinopathy of prematurity (ROP) detected by early screening of preterm infants by intravitreal injection of Ranibizumab. Background Retinopathy of prematurity is a childhood-blindness disease. Considering Ranibizumab might have a better safety profile for preterm infants, some authors shifted IVB to intravitreal injection of Ranibizumab to treat ROP. Patients and methods A clinical trial was performed between January 2021 and May 2022 in the neonatal ICU and Department of Ophthalmology, Menoufia University on 131 preterm infants. Type-I ROP cases were diagnosed and treated with intravitreal injection (IVI) of antivascular endothelial growth factor Ranibizumab 0.25 mg/0.025 ml. Injection was done 1.5 mm posterior to limbus. Both eyes were injected in the same sitting with different sterile sets. Follow-up was performed after 1 day to IVI, 1 week, and then according to stage of ROP. Results Thirty patients developed ROP severe enough to require intervention. Five (38.50%) cases had stage 2, five (38.50%) cases had stage 3, and three (23.10%) cases had aggressive posterior retinopathy of prematurity. The mean gestational age for type-1 ROP cases was 30 ± 1.8 weeks (28–35 weeks), mean birth weight was 1.3 ± 0.3 (0.950–1.6), and mean postmenstrual age was 34 ± 2. The mean follow-up time was 14 ± 1.37 months (range, 12–24 months). The efficacy of IVI of Ranibizumab in our study is 21 (80.7%) of 26 and recurrence requiring treatment occurred in five eyes from 26 (19.2%) eyes. Conclusion Single dose of Ranibizumab improving type-I ROP as regression of plus disease and newly formed vessels, and allows for continued vessel growth into the peripheral retina.
{"title":"Evaluation of treatment of retinopathy of prematurity by intravitreal injection of Ranibizumab: a clinical trial","authors":"Ahmed Fayd, Abdelhamied Allam, M. Abdelaziz","doi":"10.4103/mmj.mmj_285_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_285_22","url":null,"abstract":"Objectives Evaluation of treatment of type-I retinopathy of prematurity (ROP) detected by early screening of preterm infants by intravitreal injection of Ranibizumab. Background Retinopathy of prematurity is a childhood-blindness disease. Considering Ranibizumab might have a better safety profile for preterm infants, some authors shifted IVB to intravitreal injection of Ranibizumab to treat ROP. Patients and methods A clinical trial was performed between January 2021 and May 2022 in the neonatal ICU and Department of Ophthalmology, Menoufia University on 131 preterm infants. Type-I ROP cases were diagnosed and treated with intravitreal injection (IVI) of antivascular endothelial growth factor Ranibizumab 0.25 mg/0.025 ml. Injection was done 1.5 mm posterior to limbus. Both eyes were injected in the same sitting with different sterile sets. Follow-up was performed after 1 day to IVI, 1 week, and then according to stage of ROP. Results Thirty patients developed ROP severe enough to require intervention. Five (38.50%) cases had stage 2, five (38.50%) cases had stage 3, and three (23.10%) cases had aggressive posterior retinopathy of prematurity. The mean gestational age for type-1 ROP cases was 30 ± 1.8 weeks (28–35 weeks), mean birth weight was 1.3 ± 0.3 (0.950–1.6), and mean postmenstrual age was 34 ± 2. The mean follow-up time was 14 ± 1.37 months (range, 12–24 months). The efficacy of IVI of Ranibizumab in our study is 21 (80.7%) of 26 and recurrence requiring treatment occurred in five eyes from 26 (19.2%) eyes. Conclusion Single dose of Ranibizumab improving type-I ROP as regression of plus disease and newly formed vessels, and allows for continued vessel growth into the peripheral retina.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"27 1","pages":"2032 - 2038"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74652841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives The current study aimed to evaluate the impact of breastfeeding on female sexual functions. Background Female sexual health is an important part of her quality of life. Several influencing variables are associated to impair female sexual functions, one among them is breastfeeding. Breastfeeding creates a great potential for change of female's sexuality due to hormonal, physical, and psychological affections. Patients and methods This study was cross-sectional study. It was conducted in the period between October 2021 and January 2022. It included 400 postpartum married women in the childbearing period. The study tool was a self-report questionnaire that was designed according to the female sexual function index (FSFI) questionnaire with addition of some questions that suit the current study under supervision of this study supervisor. The questionnaire consisted of 34 questions written in English and translated into Arabic. Results Out of 400 female participants, 53% started breastfeeding from less than 6 months. About 237 (60%) women used exclusive breastfeeding and 163 (40%) used partial breastfeeding. The FSFI score less than or equal to 26.5 is the cutoff point for women with sexual dysfunction. Mean total FSFI score was 19.0 ± 5.28 in this study. The female sexual functions were greatly affected postpartum especially after 2 months. In all, 88.3% (more than three-quarters) of the participating lactating females were at high risk for sexual dysfunction. Sexual dysfunction was higher in women who practiced exclusive breastfeeding (61.75%) than partial feeding (38.25%). Conclusion Exclusive breastfeeding had a negative impact on female sexual function. They had much lower desire, orgasm, lubrication, satisfaction, and overall scale score.
{"title":"Impact of breast feeding on female sexual functions","authors":"Mohammed Gaber, Amal Ali Waly, Hend Emara","doi":"10.4103/mmj.mmj_197_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_197_22","url":null,"abstract":"Objectives The current study aimed to evaluate the impact of breastfeeding on female sexual functions. Background Female sexual health is an important part of her quality of life. Several influencing variables are associated to impair female sexual functions, one among them is breastfeeding. Breastfeeding creates a great potential for change of female's sexuality due to hormonal, physical, and psychological affections. Patients and methods This study was cross-sectional study. It was conducted in the period between October 2021 and January 2022. It included 400 postpartum married women in the childbearing period. The study tool was a self-report questionnaire that was designed according to the female sexual function index (FSFI) questionnaire with addition of some questions that suit the current study under supervision of this study supervisor. The questionnaire consisted of 34 questions written in English and translated into Arabic. Results Out of 400 female participants, 53% started breastfeeding from less than 6 months. About 237 (60%) women used exclusive breastfeeding and 163 (40%) used partial breastfeeding. The FSFI score less than or equal to 26.5 is the cutoff point for women with sexual dysfunction. Mean total FSFI score was 19.0 ± 5.28 in this study. The female sexual functions were greatly affected postpartum especially after 2 months. In all, 88.3% (more than three-quarters) of the participating lactating females were at high risk for sexual dysfunction. Sexual dysfunction was higher in women who practiced exclusive breastfeeding (61.75%) than partial feeding (38.25%). Conclusion Exclusive breastfeeding had a negative impact on female sexual function. They had much lower desire, orgasm, lubrication, satisfaction, and overall scale score.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"8 1","pages":"1680 - 1685"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72974955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Elhelbawy, M. Safan, Mostafa Elhelbawy, Basma Z. Mostafa, N. Bayomy
Objective To evaluate the relation between rs619586 metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) gene single nucleotide polymorphism (SNP) and hepatocellular carcinoma (HCC) risk on top of hepatitis C virus (HCV). Background HCC is a type of primary liver cancer. It has a multitude of etiological risk factors such as HCV. The MALAT1 is a long noncoding RNA. It affects tumor cell proliferation and migration in many types of malignancy. Patients and methods The study included 80 subjects: 40 patients with HCC on top of HCV and 40 healthy controls. Genotyping of MALAT1 SNP (rs619586) was performed by real-time PCR. Results There were no significant statistical differences regarding the genotypes or allele distribution of MALAT1 SNP (rs619586) on comparing HCC on top of HCV with controls. Conclusion This study found that there was no significant statistical difference regarding the genotypes or allele distribution of MALAT1 SNP (rs619586) on comparing HCC on top of HCV with controls.
目的探讨rs619586转移相关肺腺癌转录物1 (MALAT1)基因单核苷酸多态性(SNP)与丙型肝炎病毒(HCV)感染的肝细胞癌(HCC)发病风险的关系。HCC是原发性肝癌的一种。它有多种病因危险因素，如丙型肝炎病毒。MALAT1是一种长链非编码RNA。它影响肿瘤细胞的增殖和迁移在许多类型的恶性肿瘤。患者与方法本研究共纳入80例受试者:HCC合并HCV患者40例，健康对照40例。实时荧光定量PCR对MALAT1 SNP (rs619586)进行基因分型。结果HCC合并HCV患者与对照组相比，MALAT1 SNP (rs619586)基因型及等位基因分布差异无统计学意义。结论本研究发现，HCC合并HCV患者与对照组相比，MALAT1 SNP (rs619586)基因型及等位基因分布均无统计学差异。
{"title":"Metastasis-associated lung adenocarcinoma transcript 1 gene polymorphism in Egyptian patients with hepatocellular carcinoma","authors":"N. Elhelbawy, M. Safan, Mostafa Elhelbawy, Basma Z. Mostafa, N. Bayomy","doi":"10.4103/mmj.mmj_200_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_200_22","url":null,"abstract":"Objective To evaluate the relation between rs619586 metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) gene single nucleotide polymorphism (SNP) and hepatocellular carcinoma (HCC) risk on top of hepatitis C virus (HCV). Background HCC is a type of primary liver cancer. It has a multitude of etiological risk factors such as HCV. The MALAT1 is a long noncoding RNA. It affects tumor cell proliferation and migration in many types of malignancy. Patients and methods The study included 80 subjects: 40 patients with HCC on top of HCV and 40 healthy controls. Genotyping of MALAT1 SNP (rs619586) was performed by real-time PCR. Results There were no significant statistical differences regarding the genotypes or allele distribution of MALAT1 SNP (rs619586) on comparing HCC on top of HCV with controls. Conclusion This study found that there was no significant statistical difference regarding the genotypes or allele distribution of MALAT1 SNP (rs619586) on comparing HCC on top of HCV with controls.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"34 1","pages":"1625 - 1629"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78599645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heba Eldeen Khalil, A. Marae, Shimaa Zaki Ebrahiem, N. Tayel, Nashwa M. Muharram, E. E. El Gayed
Background Vitiligo is as an acquired, progressive disease marked by a selective loss of some or all melanocytes present in the interfollicular epidermis. Numerous immune system-related genes are connected to vitiligo susceptibility. Nonimmune tissue cells and monocytes produce interleukin-19 (IL-19), a newly discovered cytokine in the IL-10 family, when inflammation occurs. Objective To assess the role of IL-19 polymorphism and serum level in patients with vitiligo. Patients and methods A total of 80 patients with vitiligo and 80 healthy volunteers of similar age and sex participated in this case–control study. They underwent TaqMan allelic discrimination test technology (real time PCR) and blood IL-19 (rs2243188) levels using enzyme-linked immunosorbent assay method for genotyping. Results Cases had a serum IL-9 level of 94.918.7 ng/ml compared with 28.713.1 ng/ml for controls (P = 0.001), which was significantly higher. AC and CC genotypes were considerably greater in patients (P = 0.035), but AA genotype was significantly higher in controls (P < 0.001). IL-19 gene (rs2243188) polymorphism and increased IL-19 gene serum level in patients with vitiligo were strongly linked. Conclusion IL-19 C alleles might be used as an indicator for detection of vitiligo.
{"title":"Study of interleukin-19 gene polymorphism in vitiligo","authors":"Heba Eldeen Khalil, A. Marae, Shimaa Zaki Ebrahiem, N. Tayel, Nashwa M. Muharram, E. E. El Gayed","doi":"10.4103/mmj.mmj_323_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_323_22","url":null,"abstract":"Background Vitiligo is as an acquired, progressive disease marked by a selective loss of some or all melanocytes present in the interfollicular epidermis. Numerous immune system-related genes are connected to vitiligo susceptibility. Nonimmune tissue cells and monocytes produce interleukin-19 (IL-19), a newly discovered cytokine in the IL-10 family, when inflammation occurs. Objective To assess the role of IL-19 polymorphism and serum level in patients with vitiligo. Patients and methods A total of 80 patients with vitiligo and 80 healthy volunteers of similar age and sex participated in this case–control study. They underwent TaqMan allelic discrimination test technology (real time PCR) and blood IL-19 (rs2243188) levels using enzyme-linked immunosorbent assay method for genotyping. Results Cases had a serum IL-9 level of 94.918.7 ng/ml compared with 28.713.1 ng/ml for controls (P = 0.001), which was significantly higher. AC and CC genotypes were considerably greater in patients (P = 0.035), but AA genotype was significantly higher in controls (P < 0.001). IL-19 gene (rs2243188) polymorphism and increased IL-19 gene serum level in patients with vitiligo were strongly linked. Conclusion IL-19 C alleles might be used as an indicator for detection of vitiligo.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"34 1","pages":"1715 - 1720"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78389643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sameh Abd Elnaby, Mohamed Mohamed Soliman, Mostafa Etman, A. Abdelaziz
Background Acute kidney injury (AKI) is a serious complication in critically ill children. It is a risk factor for mortality, prolonged stays in the ICU, and prolonged mechanical ventilation. Objectives To investigate urinary neutrophil gelatinase-associated lipocalin (NGAL) concentrations as an early biomarker of prerenal AKI in severe dehydrated pediatric patients with acute gastroenteritis. Patients and methods A cross-sectional study was conducted during the period study from August 2020 till March 2021, on 69 children, aged from 1 to 108 months, at the pediatric ICU) of Faculty of Medicine, Menoufia University, after obtaining consent from their parents and caregivers. Results NGAL level was highly significantly increased in the death group (1550.00 ± 57.74) than in the failure group (1425.00 ± 27.39), the injury group (929.76 ± 31.18), the risk group (866.36 ± 15.89), and the normal group (810.12 ± 37.42) (P < 0.001). Conclusion Urinary NGAL is a promising biomarker of AKI before a rise in serum creatinine) occurs. Severe dehydrated children have higher urinary NGAL concentrations compared with controls even in early stage with normal creatinine levels. So, urinary NGAL levels can be used for the early prediction of tubular renal impairment in children with severe dehydration better than creatinine.
{"title":"Urinary neutrophil gelatinase-associated lipocalin in acute tubular injury among children with severe gastroenteritis","authors":"Sameh Abd Elnaby, Mohamed Mohamed Soliman, Mostafa Etman, A. Abdelaziz","doi":"10.4103/mmj.mmj_243_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_243_22","url":null,"abstract":"Background Acute kidney injury (AKI) is a serious complication in critically ill children. It is a risk factor for mortality, prolonged stays in the ICU, and prolonged mechanical ventilation. Objectives To investigate urinary neutrophil gelatinase-associated lipocalin (NGAL) concentrations as an early biomarker of prerenal AKI in severe dehydrated pediatric patients with acute gastroenteritis. Patients and methods A cross-sectional study was conducted during the period study from August 2020 till March 2021, on 69 children, aged from 1 to 108 months, at the pediatric ICU) of Faculty of Medicine, Menoufia University, after obtaining consent from their parents and caregivers. Results NGAL level was highly significantly increased in the death group (1550.00 ± 57.74) than in the failure group (1425.00 ± 27.39), the injury group (929.76 ± 31.18), the risk group (866.36 ± 15.89), and the normal group (810.12 ± 37.42) (P < 0.001). Conclusion Urinary NGAL is a promising biomarker of AKI before a rise in serum creatinine) occurs. Severe dehydrated children have higher urinary NGAL concentrations compared with controls even in early stage with normal creatinine levels. So, urinary NGAL levels can be used for the early prediction of tubular renal impairment in children with severe dehydration better than creatinine.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"61 1","pages":"1802 - 1809"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76151411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives The purpose of this study was to compare the patency rate and associated complications using different types of synthetic grafts used in hemodialysis access. Background Polytetrafluoroethylene (PTFE) recently gained popularity as a graft material for hemodialysis access. PTFE has been modified by many ways such as adding rings [ringed polytetrafluoroethylene (rPTFE)] or adding an outer layer of polyethylene terephthalate [hybrid polytetrafluoroethylene (hPTFE)]. Modifications in PTFE have been developed to improve the outcome; however, to date no PTFE graft has demonstrated clear superiority over competitive products. Patients and methods The study was performed as a prospective observational cohort study between January 2019 and January 2022 at Menoufia University Hospitals. In all, 50 patients underwent brachio-axillary straight graft using different graft type's rPTFE, standard polytetrafluoroethylene (sPTFE), and hPTFE (fusion graft). Patency and complications rates were compared between the three groups. Results We found that rPTFE grafts have lower thrombosis and infection rates than hPTFE and sPTFE grafts. Also, there was no pseudoaneurysm or postdialysis subcutaneous hematoma formation in the rPTFE group during the follow-up period. Also, the 1-year primary patency rates were 73.3, 73.7, and 81.3% in the hPTFE, sPTFE, and rPTFE groups, respectively. Conclusion The feasibility and superiority of externally supported arteriovenous graft in comparison to nonsupported arteriovenous graft for primary patency in dialysis access has been shown by this study.
{"title":"Graft materials as vascular substitutes for hemodialysis access construction","authors":"Yahia Alkhateep, Hasanain F. Hasan, Said Elmallah","doi":"10.4103/mmj.mmj_272_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_272_22","url":null,"abstract":"Objectives The purpose of this study was to compare the patency rate and associated complications using different types of synthetic grafts used in hemodialysis access. Background Polytetrafluoroethylene (PTFE) recently gained popularity as a graft material for hemodialysis access. PTFE has been modified by many ways such as adding rings [ringed polytetrafluoroethylene (rPTFE)] or adding an outer layer of polyethylene terephthalate [hybrid polytetrafluoroethylene (hPTFE)]. Modifications in PTFE have been developed to improve the outcome; however, to date no PTFE graft has demonstrated clear superiority over competitive products. Patients and methods The study was performed as a prospective observational cohort study between January 2019 and January 2022 at Menoufia University Hospitals. In all, 50 patients underwent brachio-axillary straight graft using different graft type's rPTFE, standard polytetrafluoroethylene (sPTFE), and hPTFE (fusion graft). Patency and complications rates were compared between the three groups. Results We found that rPTFE grafts have lower thrombosis and infection rates than hPTFE and sPTFE grafts. Also, there was no pseudoaneurysm or postdialysis subcutaneous hematoma formation in the rPTFE group during the follow-up period. Also, the 1-year primary patency rates were 73.3, 73.7, and 81.3% in the hPTFE, sPTFE, and rPTFE groups, respectively. Conclusion The feasibility and superiority of externally supported arteriovenous graft in comparison to nonsupported arteriovenous graft for primary patency in dialysis access has been shown by this study.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"22 1","pages":"1939 - 1942"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78048788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives To evaluate the serum ischemia-modified albumin (IMA) level in patients with primary infertility as a useful marker for assessing oxidative stress. Background Infertility is a condition affecting 15% of the world's population. IMA is calculated through the evaluation of the binding of cobalt to albumin. Patients and methods This prospective study was conducted on 40 male patients of primary infertility with completely normal partner and 40 apparently healthy volunteers as a control group. Every participant was subjected to laboratory tests (complete blood count, liver and renal functions, hemoglobin A1c, measurement of serum IMA by enzyme-linked immunosorbent assay, and semen analysis) and scrotal ultrasound. Results IMA was significantly higher in the case group compared with the control group (P < 0.001). Sperm count per milliliter was significantly lower in the case group compared with the control group (P < 0.001). Red blood cell count was significantly higher in the case group compared with the control group (P = 0.002), whereas white blood cell count was significantly lower in the case group compared with the control group (P = 0.001). Conclusion Both RBC count and IMA were significantly higher in cases compared with the control group. IMA may be a good predictor for patients with oligozoospermia due to reactive oxygen species injury.
{"title":"Ischemia-modified albumin as a predicting biomarker of oxidative stress in males with primary infertility","authors":"M. Shoeib, Reem Hassan, N. Bayomy, Hanan Derbala","doi":"10.4103/mmj.mmj_283_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_283_22","url":null,"abstract":"Objectives To evaluate the serum ischemia-modified albumin (IMA) level in patients with primary infertility as a useful marker for assessing oxidative stress. Background Infertility is a condition affecting 15% of the world's population. IMA is calculated through the evaluation of the binding of cobalt to albumin. Patients and methods This prospective study was conducted on 40 male patients of primary infertility with completely normal partner and 40 apparently healthy volunteers as a control group. Every participant was subjected to laboratory tests (complete blood count, liver and renal functions, hemoglobin A1c, measurement of serum IMA by enzyme-linked immunosorbent assay, and semen analysis) and scrotal ultrasound. Results IMA was significantly higher in the case group compared with the control group (P < 0.001). Sperm count per milliliter was significantly lower in the case group compared with the control group (P < 0.001). Red blood cell count was significantly higher in the case group compared with the control group (P = 0.002), whereas white blood cell count was significantly lower in the case group compared with the control group (P = 0.001). Conclusion Both RBC count and IMA were significantly higher in cases compared with the control group. IMA may be a good predictor for patients with oligozoospermia due to reactive oxygen species injury.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"28 1","pages":"1697 - 1702"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81731293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dina Midan, M. Elshafie, Rehab Ali Mostafa, Noha M. Ashour
Background Hyperbilirubinemia is the most common condition requiring evaluation and treatment in newborns. Approximately 60% of term and 80% of preterm babies develop jaundice in the first week of life. Objectives To assess the role of carboxyhemoglobin (COHb) as an early predictor for pathological hyperbilirubinemia in preterm neonates. Patients and methods This prospective cohort study was conducted on 74 preterm newborns of less than 37 weeks gestation of both sexes, admitted in the first day of life at the neonatal ICU of Menoufia University Hospital from August 2019 to August 2020. All included newborns had serum COHb percentage and total serum bilirubin levels measured just after admission and then were followed up for developing pathological hyperbilirubinemia for 72 h. The case group included 40 preterm neonates who developed pathological hyperbilirubinemia from 24 to 72 h of life while the control group included 34 preterm neonates who did not develop pathological hyperbilirubinemia within the first 72 h of life. Results Both COHb percentage and total serum bilirubin level just after admission were significantly higher in cases than in controls (COHb 1.14 ± 0.28% in cases vs. 0.82 ± 0.22 in controls with P < 0.001). Receiver-operating characteristic case analysis showed that the cutoff point of COHb percentage just after admission more than 1.13% had 77.5% sensitivity and 80.2% specificity for cases with significant neonatal hyperbilirubinemia. Conclusion Serum COHb percentage at admission is a sensitive and specific method to predict preterm neonates who will develop pathological hyperbilirubinemia.
{"title":"Carboxyhemoglobin as an early predictor for pathological hyperbilirubinemia in preterm neonates","authors":"Dina Midan, M. Elshafie, Rehab Ali Mostafa, Noha M. Ashour","doi":"10.4103/mmj.mmj_211_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_211_22","url":null,"abstract":"Background Hyperbilirubinemia is the most common condition requiring evaluation and treatment in newborns. Approximately 60% of term and 80% of preterm babies develop jaundice in the first week of life. Objectives To assess the role of carboxyhemoglobin (COHb) as an early predictor for pathological hyperbilirubinemia in preterm neonates. Patients and methods This prospective cohort study was conducted on 74 preterm newborns of less than 37 weeks gestation of both sexes, admitted in the first day of life at the neonatal ICU of Menoufia University Hospital from August 2019 to August 2020. All included newborns had serum COHb percentage and total serum bilirubin levels measured just after admission and then were followed up for developing pathological hyperbilirubinemia for 72 h. The case group included 40 preterm neonates who developed pathological hyperbilirubinemia from 24 to 72 h of life while the control group included 34 preterm neonates who did not develop pathological hyperbilirubinemia within the first 72 h of life. Results Both COHb percentage and total serum bilirubin level just after admission were significantly higher in cases than in controls (COHb 1.14 ± 0.28% in cases vs. 0.82 ± 0.22 in controls with P < 0.001). Receiver-operating characteristic case analysis showed that the cutoff point of COHb percentage just after admission more than 1.13% had 77.5% sensitivity and 80.2% specificity for cases with significant neonatal hyperbilirubinemia. Conclusion Serum COHb percentage at admission is a sensitive and specific method to predict preterm neonates who will develop pathological hyperbilirubinemia.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":" 4","pages":"1816 - 1821"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91413055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marwa Salah Mahmoud, M. Lotfy, Mohammed El-Bahhar, Sabry Abdullah
Objectives We aimed to assess the analgesic efficacy of the ultrasound-guided block of rectus sheath (RS) versus subcostal transversus abdominis plane (TAP) versus quadratus lumborum in laparoscopic cholecystectomy. Background Regional anesthesia has become an essential component of multimodal analgesia to reduce stress-induced physiologic responses. Patients and methods A prospective randomized trial was carried out on 66 patients who were divided into three equal groups, with 22 patients each. Group R received a block of the RS. Group T received a block of the subcostal TAP. Group Q received a posterior quadratus lumborum block. All of them were given a dose of 20-ml bupivacaine 0.25% bilaterally using ultrasound guidance. We assessed the severity of pain postoperatively by the visual analog scale, the time for the first request for rescue analgesia, and the total amount of postoperative ketorolac consumption. Results Group Q had significantly lower visual analog scale score values than the others and group T than group R. Time for the first request for analgesia in group Q was significantly longer than the others and in the T group than in the R group. Ketorolac consumption was significantly lower in group Q than the others and in group T than group R. Postoperative nausea and vomiting were significantly higher in group R than in the others. Conclusion Quadratus lumborum block was the most effective analgesic technique after laparoscopic cholecystectomy compared with subcostal TAP and RS blocks.
{"title":"Ultrasound-guided rectus sheath versus subcostal transversus abdominis plane versus quadratus lumborum blocks in laparoscopic cholecystectomy","authors":"Marwa Salah Mahmoud, M. Lotfy, Mohammed El-Bahhar, Sabry Abdullah","doi":"10.4103/mmj.mmj_295_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_295_22","url":null,"abstract":"Objectives We aimed to assess the analgesic efficacy of the ultrasound-guided block of rectus sheath (RS) versus subcostal transversus abdominis plane (TAP) versus quadratus lumborum in laparoscopic cholecystectomy. Background Regional anesthesia has become an essential component of multimodal analgesia to reduce stress-induced physiologic responses. Patients and methods A prospective randomized trial was carried out on 66 patients who were divided into three equal groups, with 22 patients each. Group R received a block of the RS. Group T received a block of the subcostal TAP. Group Q received a posterior quadratus lumborum block. All of them were given a dose of 20-ml bupivacaine 0.25% bilaterally using ultrasound guidance. We assessed the severity of pain postoperatively by the visual analog scale, the time for the first request for rescue analgesia, and the total amount of postoperative ketorolac consumption. Results Group Q had significantly lower visual analog scale score values than the others and group T than group R. Time for the first request for analgesia in group Q was significantly longer than the others and in the T group than in the R group. Ketorolac consumption was significantly lower in group Q than the others and in group T than group R. Postoperative nausea and vomiting were significantly higher in group R than in the others. Conclusion Quadratus lumborum block was the most effective analgesic technique after laparoscopic cholecystectomy compared with subcostal TAP and RS blocks.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"20 1","pages":"1915 - 1923"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83557433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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