Objectives To evaluate the relationship between sexual myths and sexual function among women. Background Sexual myths are false beliefs about sexuality that are not related to proven scientific evidence. They are spread through the transmission of false and exaggerated information and are shaped and fueled by the imagination of the community. Patients and methods The current study was carried out after approval by the Dermatology and Andrology Department and Medical Ethics Committee, Faculty of Medicine, Menoufia University. Results There was no statistically significant relationship between sexual function and sexual myths among women, such as immoral woman initiates sexual activity, seafood increases desire, fatty meals increase desire, first sexual intercourse is always painful, blood is a sign of virginity, masturbation could rupture hymen, as well as masturbation is harmful (P > 0.05). There was no statistically significant relationship between sexual function and sexual myths among women such as oral sex is religiously forbidden, oral sex transmits infection, female sexual areas are dirty, genital cutting prevents sexual arousal, pregnancy decreases desire, intercourse is forbidden during pregnancy, as well as women have less sexual desire (P > 0.05). Conclusion From the results of the present study, we have found that participants had a high number of wrong beliefs. Despite the presence of these myths among women, there was no effect on sexual function, as majority of cases have fair sexual function.
{"title":"Relationship between sexual myths and sexual function among women","authors":"Mohammed Gaber, Asmaa Shaban, Hend Emara","doi":"10.4103/mmj.mmj_289_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_289_22","url":null,"abstract":"Objectives To evaluate the relationship between sexual myths and sexual function among women. Background Sexual myths are false beliefs about sexuality that are not related to proven scientific evidence. They are spread through the transmission of false and exaggerated information and are shaped and fueled by the imagination of the community. Patients and methods The current study was carried out after approval by the Dermatology and Andrology Department and Medical Ethics Committee, Faculty of Medicine, Menoufia University. Results There was no statistically significant relationship between sexual function and sexual myths among women, such as immoral woman initiates sexual activity, seafood increases desire, fatty meals increase desire, first sexual intercourse is always painful, blood is a sign of virginity, masturbation could rupture hymen, as well as masturbation is harmful (P > 0.05). There was no statistically significant relationship between sexual function and sexual myths among women such as oral sex is religiously forbidden, oral sex transmits infection, female sexual areas are dirty, genital cutting prevents sexual arousal, pregnancy decreases desire, intercourse is forbidden during pregnancy, as well as women have less sexual desire (P > 0.05). Conclusion From the results of the present study, we have found that participants had a high number of wrong beliefs. Despite the presence of these myths among women, there was no effect on sexual function, as majority of cases have fair sexual function.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"26 1","pages":"1703 - 1708"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88190047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sadik Sadik, A. Rady, Norhan Hamouda, Alaaelddin Elsakka
Objectives To compare the perioperative analgesic efficacy of serratus anterior plan block (SAPB) versus paravertebral block in patients undergoing mastectomy surgery. Background Patients undergoing mastectomy surgery often experience severe postoperative pain. Inadequate control of this pain increases the risk of postoperative complications and may develop into chronic pain. Patients and methods This prospective randomized trial was carried out on 60 female patients, American Society of Anesthesiologists I–III, 30–60 years old, scheduled for modified radical mastectomy, between April 2020 and March 2021. The patients were randomly allocated into one of two groups (30 patients each). Group S received ultrasound-guided SAPB and group P received ultrasound-guided thoracic paravertebral block (TPVB). In both blocks, the injectate was 20-ml bupivacaine 0.25% with epinephrine (5 μg/ml) and fentanyl (2 μg/ml). Both blocks were performed as a single injection after general anesthesia induction. Intraoperative fentanyl consumption, postoperative visual analog scale scores, time-to-first ketorolac request, total postoperative ketorolac consumption, and patients' satisfaction were recorded. Data were analyzed by SPSS, version 26, Mann–Whitney test, Student t test, and variance test. Results Both groups had comparable intraoperative fentanyl consumption (P = 0.15). However TPVB was associated with significantly lower postoperative analgesic requirements, longer time to first analgesic request, and higher grade of patient satisfaction (P < 0.001). Visual analog scale scores were significantly lower in group P at 2, 3, 8, and 17 h (P < 0.001) while being comparable at the remaining time points. Conclusion TPVB and SAPB were associated with comparable intraoperative analgesic efficacy; however, TPVB was associated with a better postoperative analgesic profile and patient satisfaction.
{"title":"Analgesic efficacy of serratus anterior plane block versus paravertebral block in mastectomy surgery","authors":"Sadik Sadik, A. Rady, Norhan Hamouda, Alaaelddin Elsakka","doi":"10.4103/mmj.mmj_254_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_254_22","url":null,"abstract":"Objectives To compare the perioperative analgesic efficacy of serratus anterior plan block (SAPB) versus paravertebral block in patients undergoing mastectomy surgery. Background Patients undergoing mastectomy surgery often experience severe postoperative pain. Inadequate control of this pain increases the risk of postoperative complications and may develop into chronic pain. Patients and methods This prospective randomized trial was carried out on 60 female patients, American Society of Anesthesiologists I–III, 30–60 years old, scheduled for modified radical mastectomy, between April 2020 and March 2021. The patients were randomly allocated into one of two groups (30 patients each). Group S received ultrasound-guided SAPB and group P received ultrasound-guided thoracic paravertebral block (TPVB). In both blocks, the injectate was 20-ml bupivacaine 0.25% with epinephrine (5 μg/ml) and fentanyl (2 μg/ml). Both blocks were performed as a single injection after general anesthesia induction. Intraoperative fentanyl consumption, postoperative visual analog scale scores, time-to-first ketorolac request, total postoperative ketorolac consumption, and patients' satisfaction were recorded. Data were analyzed by SPSS, version 26, Mann–Whitney test, Student t test, and variance test. Results Both groups had comparable intraoperative fentanyl consumption (P = 0.15). However TPVB was associated with significantly lower postoperative analgesic requirements, longer time to first analgesic request, and higher grade of patient satisfaction (P < 0.001). Visual analog scale scores were significantly lower in group P at 2, 3, 8, and 17 h (P < 0.001) while being comparable at the remaining time points. Conclusion TPVB and SAPB were associated with comparable intraoperative analgesic efficacy; however, TPVB was associated with a better postoperative analgesic profile and patient satisfaction.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"68 1","pages":"1910 - 1914"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78826635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives The aim of the study was to evaluate serum ghrelin in nonobese patients with moderate-to-severe acne vulgaris. Background Acne vulgaris is a multifactorial disease that affects mostly the adolescent population, but it is difficult to predict those who are prone to severe forms. Patients and methods A case–control study was conducted on 80 participants selected from the Dermatology Outpatient Clinic at Menoufia University Hospital during the period of study from March 2019 till December 2020. Full history taking and clinical and dermatological examinations were done. Serum ghrelin level was measured using the enzyme-linked immunosorbent assay. Results There was highly statistically significant difference between the two studied groups regarding serum ghrelin level. There was significant negative correlation between the severity according to The Global Acne Grading System with serum ghrelin level groups in terms of fasting glucose level, triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein. Conclusion There is a relationship between acne vulgaris and the level of ghrelin hormone, which is decreased in the serum of acne patients.
{"title":"Evaluation of serum ghrelin in patients with acne vulgaris","authors":"M. Basha, Maathir El-Shafei, Donya Boraey","doi":"10.4103/mmj.mmj_244_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_244_22","url":null,"abstract":"Objectives The aim of the study was to evaluate serum ghrelin in nonobese patients with moderate-to-severe acne vulgaris. Background Acne vulgaris is a multifactorial disease that affects mostly the adolescent population, but it is difficult to predict those who are prone to severe forms. Patients and methods A case–control study was conducted on 80 participants selected from the Dermatology Outpatient Clinic at Menoufia University Hospital during the period of study from March 2019 till December 2020. Full history taking and clinical and dermatological examinations were done. Serum ghrelin level was measured using the enzyme-linked immunosorbent assay. Results There was highly statistically significant difference between the two studied groups regarding serum ghrelin level. There was significant negative correlation between the severity according to The Global Acne Grading System with serum ghrelin level groups in terms of fasting glucose level, triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein. Conclusion There is a relationship between acne vulgaris and the level of ghrelin hormone, which is decreased in the serum of acne patients.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"31 1","pages":"1662 - 1667"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78832114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahy Egiz, Mohammed Sayed, Alaa Abdelgaied, Dalia Elkhuly, S. El-deeb
Objective To determine the benefit of assessment of cervicovaginal placental alpha-microglobulin 1 (PAMG-1) with the cervical biometry in prediction of preterm labor (PTL). Background Many screening methods are now used for the diagnosis of PTL. Short cervix in the second trimester, detected by transvaginal ultrasound, was significantly related to PTL. The presence of PAMG-1 in cervicovaginal discharge of women with clinically intact membranes is indicative of imminent delivery. Patients and methods This prospective longitudinal study was conducted on 90 pregnant women and divided into two equal groups: group A included 45 pregnant women between 24+0 and 36+6 weeks with threatened PTL and short cervix, and group B included 45 pregnant women at the same age group without threatened PTL symptoms and with normal cervical biometry. Results Women of preterm group had statistically significant shorter cervical length (15.6% <15 mm, 48.9% between 15 and 20 mm, and 35.6% between 20 and 24 mm; P ≤ 0.001) and more detectable positive cervicovaginal fluid PAMG-1 (32 vs. 0; P < 0.001). Cervical PAMG-1 had a sensitivity of 71.11%, a specificity of 100.0%, a positive predictive value of 100%, a negative predictive value of 77.59, and an accuracy of 85.56%. Moreover, there was a strong correlation between positive PAMG and time of delivery, as 18.8% gave birth in first 48 h, 50.0% gave birth between 2 and 7 days, and 31.3% gave birth after 7 days. On the contrary, all women with negative PAMG gave birth after 7 days. Conclusions Regular use of the two tests described could help identify low-risk patients and lower the number of unnecessary hospitalizations and treatments.
{"title":"The predictive value of cervical biometry and placental alpha-microglobulin 1 in cervicovaginal fluid in preterm labor","authors":"Mahy Egiz, Mohammed Sayed, Alaa Abdelgaied, Dalia Elkhuly, S. El-deeb","doi":"10.4103/mmj.mmj_228_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_228_22","url":null,"abstract":"Objective To determine the benefit of assessment of cervicovaginal placental alpha-microglobulin 1 (PAMG-1) with the cervical biometry in prediction of preterm labor (PTL). Background Many screening methods are now used for the diagnosis of PTL. Short cervix in the second trimester, detected by transvaginal ultrasound, was significantly related to PTL. The presence of PAMG-1 in cervicovaginal discharge of women with clinically intact membranes is indicative of imminent delivery. Patients and methods This prospective longitudinal study was conducted on 90 pregnant women and divided into two equal groups: group A included 45 pregnant women between 24+0 and 36+6 weeks with threatened PTL and short cervix, and group B included 45 pregnant women at the same age group without threatened PTL symptoms and with normal cervical biometry. Results Women of preterm group had statistically significant shorter cervical length (15.6% <15 mm, 48.9% between 15 and 20 mm, and 35.6% between 20 and 24 mm; P ≤ 0.001) and more detectable positive cervicovaginal fluid PAMG-1 (32 vs. 0; P < 0.001). Cervical PAMG-1 had a sensitivity of 71.11%, a specificity of 100.0%, a positive predictive value of 100%, a negative predictive value of 77.59, and an accuracy of 85.56%. Moreover, there was a strong correlation between positive PAMG and time of delivery, as 18.8% gave birth in first 48 h, 50.0% gave birth between 2 and 7 days, and 31.3% gave birth after 7 days. On the contrary, all women with negative PAMG gave birth after 7 days. Conclusions Regular use of the two tests described could help identify low-risk patients and lower the number of unnecessary hospitalizations and treatments.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"6 1","pages":"1964 - 1969"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90197401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives The aim was to assess the role of leukocyte estrase reagent strips and myeloperoxidase (MPO) for diagnosing spontaneous bacterial peritonitis (SBP) in cirrhotic patients. Background Liver cirrhosis represents one of the major causes of death worldwide. Cirrhotic patients with ascites show a higher susceptibility to bacterial infections with SBP that is the most frequent infectious complication. The gold standard for diagnosing SBP is a polymorphonuclear neutrophil count of 250 cells/μl in ascitic fluid. Urine reagent strips have been proposed as a rapid and inexpensive alternative. MPO has a preoxidant–proinflammatory property and its level increases in cases of infection. Patients and methods In total, 90 patients with decompensated chronic liver disease and ascites participated in this study, including (Group I) 20 patients having no symptoms and PMN count (<250 cells/mm3), (Group II) 35 patients with a picture of SBP and PMN count <250 cells/mm3, and (Group III) 35 symptomatic patients with PMN count >250 cells/mm3. Ascitic PMN count and MPO level were measured. Also, ascetic fluid samples were assessed by leukocyte esterase reagent strips (LERS). Results The mean value of MPO was statistically significantly higher in group III (1640.1 ± 480.6 ng/ml) than group II (595.4 ± 201.3 ng/ml) than group I (479.2 ± 236.2 ng/ml). The cutoff value of ascetic MPO was greater than 959.7 ng/ml with accuracy 100%. The mean value of LERS was significantly higher in group III (230 ± 210.8) than group I (14 ± 10.2) and group II (13 ± 9.9). The cutoff value of LERS was greater than 15 leukocytes/μl with accuracy 76%. Conclusion Rapid bedside diagnostic tests for SBP could be performed using MPO and LERS.
{"title":"Role of leukocyte estrase reagent strips and myeloperoxidase for diagnosing spontaneous bacterial peritonitis","authors":"A. Ali, Eman Elsayed Badr, Alaa Metawea, A. Teima","doi":"10.4103/mmj.mmj_141_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_141_22","url":null,"abstract":"Objectives The aim was to assess the role of leukocyte estrase reagent strips and myeloperoxidase (MPO) for diagnosing spontaneous bacterial peritonitis (SBP) in cirrhotic patients. Background Liver cirrhosis represents one of the major causes of death worldwide. Cirrhotic patients with ascites show a higher susceptibility to bacterial infections with SBP that is the most frequent infectious complication. The gold standard for diagnosing SBP is a polymorphonuclear neutrophil count of 250 cells/μl in ascitic fluid. Urine reagent strips have been proposed as a rapid and inexpensive alternative. MPO has a preoxidant–proinflammatory property and its level increases in cases of infection. Patients and methods In total, 90 patients with decompensated chronic liver disease and ascites participated in this study, including (Group I) 20 patients having no symptoms and PMN count (<250 cells/mm3), (Group II) 35 patients with a picture of SBP and PMN count <250 cells/mm3, and (Group III) 35 symptomatic patients with PMN count >250 cells/mm3. Ascitic PMN count and MPO level were measured. Also, ascetic fluid samples were assessed by leukocyte esterase reagent strips (LERS). Results The mean value of MPO was statistically significantly higher in group III (1640.1 ± 480.6 ng/ml) than group II (595.4 ± 201.3 ng/ml) than group I (479.2 ± 236.2 ng/ml). The cutoff value of ascetic MPO was greater than 959.7 ng/ml with accuracy 100%. The mean value of LERS was significantly higher in group III (230 ± 210.8) than group I (14 ± 10.2) and group II (13 ± 9.9). The cutoff value of LERS was greater than 15 leukocytes/μl with accuracy 76%. Conclusion Rapid bedside diagnostic tests for SBP could be performed using MPO and LERS.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"55 1","pages":"1746 - 1752"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89341415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives This study aimed to assess serum brain-derived neurotrophic factor (BDNF) levels in female patients with acne vulgaris and to assess the relationship of this biomarker to the degree of psychological symptoms developed in these patients. Background Acne vulgaris is a benign self-limited condition. However, patients usually endure anxiety, depression, poor body image, frustration, anger, diminished confidence and self-esteem, social isolation, and restriction of activities because it commonly affects the face during a sociosexually critical age, causing a considerable cosmetic concern with adverse social and psychological consequences on the quality of life. Patients and methods Serum BDNF levels were measured in 60 female patients with acne vulgaris divided into three groups according to the severity and 30 age- and sex-matched healthy controls using enzyme-linked immunosorbent assay. Patients filled a Dermatology Life Quality Index questionnaire; both patients and controls filled a Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale-10 (PSS) questionnaires. Results Serum BDNF levels were significantly lower in acne patients when compared with healthy controls and those levels were lowest in the severe group. HADS and PSS scores of the patients were significantly higher than those in the control group. Statistically significant negative correlations were found between serum BDNF levels and scores. Conclusion Serum BDNF levels decreased significantly in acne vulgaris, indicating the role it may play in the development of psychological symptoms, which make patients with acne more liable to anxiety, depression, and stress.
{"title":"Serum levels of brain-derived neurotrophic factor, association with psychological symptoms in females with acne vulgaris","authors":"M. Hagag, R. Azmy, Enas Deshesh","doi":"10.4103/mmj.mmj_274_21","DOIUrl":"https://doi.org/10.4103/mmj.mmj_274_21","url":null,"abstract":"Objectives This study aimed to assess serum brain-derived neurotrophic factor (BDNF) levels in female patients with acne vulgaris and to assess the relationship of this biomarker to the degree of psychological symptoms developed in these patients. Background Acne vulgaris is a benign self-limited condition. However, patients usually endure anxiety, depression, poor body image, frustration, anger, diminished confidence and self-esteem, social isolation, and restriction of activities because it commonly affects the face during a sociosexually critical age, causing a considerable cosmetic concern with adverse social and psychological consequences on the quality of life. Patients and methods Serum BDNF levels were measured in 60 female patients with acne vulgaris divided into three groups according to the severity and 30 age- and sex-matched healthy controls using enzyme-linked immunosorbent assay. Patients filled a Dermatology Life Quality Index questionnaire; both patients and controls filled a Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale-10 (PSS) questionnaires. Results Serum BDNF levels were significantly lower in acne patients when compared with healthy controls and those levels were lowest in the severe group. HADS and PSS scores of the patients were significantly higher than those in the control group. Statistically significant negative correlations were found between serum BDNF levels and scores. Conclusion Serum BDNF levels decreased significantly in acne vulgaris, indicating the role it may play in the development of psychological symptoms, which make patients with acne more liable to anxiety, depression, and stress.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"62 1","pages":"1709 - 1714"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87992530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives To present the various adverse effects of topical prostaglandin analogs on the periorbita. Background The authors studied the prostaglandin-related adverse effects on the periorbita and compared each analog in a sample of patients with glaucoma. Patients and methods A case series study was performed on the adverse effects on the periorbita noticed in glaucomatous patients who were controlled by prostaglandin in Menoufia University Hospital and Cairo Fatemic Hospital. The study was done on 100 patients aged from 18 to 75 years at outpatient clinics. Results A total of 100 patients were found to have a variety of disorders, including deepening of the superior sulci (42/100), hypertrichosis (23/100), lengthening of eyelashes (48/100), and hyperpigmentation of the skin surrounding the eye (40/100). Conclusion Although topical prostaglandin analogs are well tolerated by many patients, some individuals who use these medications complain of structural changes in the periorbita, resulting in a variety of cosmetic and eyelid disorders, such as lengthening of eyelashes, hypertrichosis, hyperpigmentation of the skin surrounding the eye, and deepening of sulci.
{"title":"Study of the effect of prostaglandin analogs on the periorbita of glaucomatous patients","authors":"Hoda El Sobky, Sameh S Mandour, Amr Awwad","doi":"10.4103/mmj.mmj_255_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_255_22","url":null,"abstract":"Objectives To present the various adverse effects of topical prostaglandin analogs on the periorbita. Background The authors studied the prostaglandin-related adverse effects on the periorbita and compared each analog in a sample of patients with glaucoma. Patients and methods A case series study was performed on the adverse effects on the periorbita noticed in glaucomatous patients who were controlled by prostaglandin in Menoufia University Hospital and Cairo Fatemic Hospital. The study was done on 100 patients aged from 18 to 75 years at outpatient clinics. Results A total of 100 patients were found to have a variety of disorders, including deepening of the superior sulci (42/100), hypertrichosis (23/100), lengthening of eyelashes (48/100), and hyperpigmentation of the skin surrounding the eye (40/100). Conclusion Although topical prostaglandin analogs are well tolerated by many patients, some individuals who use these medications complain of structural changes in the periorbita, resulting in a variety of cosmetic and eyelid disorders, such as lengthening of eyelashes, hypertrichosis, hyperpigmentation of the skin surrounding the eye, and deepening of sulci.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"89 1","pages":"2027 - 2031"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87414282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective The aim of this study was to evaluate the correlation between serum levels of a specific matrix metalloproteinase, matrix metalloproteinase-9 (MMP-9), and the angiographic criteria of coronary artery ectasia (CAE). Background Previously, CAE was thought to be a possible manifestation of atherosclerosis, and the relation between matrix metalloproteinase in particular MMP-9 and presence and severity of CAE was not clearly established by previous investigators. Patients and methods A retrospective study of 100 eligible patients with CAE was studied regarding their clinical presentation, angiographic criteria, and relation of the severity of CAE to serum level of MMP-9. We included assessment of major cardiovascular risk factors. Results There were high serum levels of MMP-9 (>71 ug/dl) in 45% of patients with CAE, and there was a statistically significant relation (P = 0.035) of serum levels of MMP-9 with the number of ectatic vessels (100% for three-vessel disease vs. 43.38% for single-vessel ectasia). Moreover, we found a significant relation with the type of ectasia (83.33% for type 1 vs. 40% for type 2), with P = 0.015. Conclusions There is a considerable relationship between elevated levels of MMP-9 and CAE, as well as the relationship between levels of MMP-9 and severity of the CAE.
{"title":"Effect of matrix metalloproteinase-9 on angiographic criteria of coronary ectasia","authors":"Walaa Mousa, Wessam Elshafey, R. Adly","doi":"10.4103/mmj.mmj_233_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_233_22","url":null,"abstract":"Objective The aim of this study was to evaluate the correlation between serum levels of a specific matrix metalloproteinase, matrix metalloproteinase-9 (MMP-9), and the angiographic criteria of coronary artery ectasia (CAE). Background Previously, CAE was thought to be a possible manifestation of atherosclerosis, and the relation between matrix metalloproteinase in particular MMP-9 and presence and severity of CAE was not clearly established by previous investigators. Patients and methods A retrospective study of 100 eligible patients with CAE was studied regarding their clinical presentation, angiographic criteria, and relation of the severity of CAE to serum level of MMP-9. We included assessment of major cardiovascular risk factors. Results There were high serum levels of MMP-9 (>71 ug/dl) in 45% of patients with CAE, and there was a statistically significant relation (P = 0.035) of serum levels of MMP-9 with the number of ectatic vessels (100% for three-vessel disease vs. 43.38% for single-vessel ectasia). Moreover, we found a significant relation with the type of ectasia (83.33% for type 1 vs. 40% for type 2), with P = 0.015. Conclusions There is a considerable relationship between elevated levels of MMP-9 and CAE, as well as the relationship between levels of MMP-9 and severity of the CAE.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"1 1","pages":"1630 - 1634"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84847220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To study the association between pre-pubertal acne and dehydroepiandrosterone (DHEA) level. Background Acne vulgaris is a common skin disease. Pre-pubertal acne is due to maturation of ovary and testis. During adrenarche (10–14 years old in females and 12–16 years in males), there is an increase in secretion of DHEA and DHEA sulfate by adrenal glands, leading to activation of sebaceous glands. DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche. Patients and methods A cross-sectional survey was carried out in Menoufia Governorate, Shebin El-Kom District, basic education schools (rural and urban). Students included both females and males. Results This study found that there was an increased level of DHEA hormone in pre-pubertal acne. The prevalence of acne among the studied group was 47%. The types of acne among acne-positive students were as follows: 48.9% were comedonal, 21.3% inflammatory, and 29.8% both comedonal and inflammatory. Sites of acne among acne-positive students were as follows: 14.9% were cheek, 27.7% chain, 42.6% forehead, and 14.9% nose. The current study showed an insignificant relation between acne and age. The percentage of males was the most predominant in acne-positive cases (57.4%). This study showed an insignificant relation between food consumption and acne. The current study showed that the percentage of present puberty signs was statistically significant lower among acne-positive than acne-negative. Conclusion There was a statistically significant increase in DHEA level among acne-positive compared with acne-negative cases.
{"title":"Prevalence and risk factors of pre-pubertal acne among school children in menoufia governorate, Egypt","authors":"M. Hagag, Asmaa Roushdy, Gaafar Abd EL Rasoul","doi":"10.4103/mmj.mmj_176_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_176_22","url":null,"abstract":"Objective To study the association between pre-pubertal acne and dehydroepiandrosterone (DHEA) level. Background Acne vulgaris is a common skin disease. Pre-pubertal acne is due to maturation of ovary and testis. During adrenarche (10–14 years old in females and 12–16 years in males), there is an increase in secretion of DHEA and DHEA sulfate by adrenal glands, leading to activation of sebaceous glands. DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the androgenic effects of adrenarche. Patients and methods A cross-sectional survey was carried out in Menoufia Governorate, Shebin El-Kom District, basic education schools (rural and urban). Students included both females and males. Results This study found that there was an increased level of DHEA hormone in pre-pubertal acne. The prevalence of acne among the studied group was 47%. The types of acne among acne-positive students were as follows: 48.9% were comedonal, 21.3% inflammatory, and 29.8% both comedonal and inflammatory. Sites of acne among acne-positive students were as follows: 14.9% were cheek, 27.7% chain, 42.6% forehead, and 14.9% nose. The current study showed an insignificant relation between acne and age. The percentage of males was the most predominant in acne-positive cases (57.4%). This study showed an insignificant relation between food consumption and acne. The current study showed that the percentage of present puberty signs was statistically significant lower among acne-positive than acne-negative. Conclusion There was a statistically significant increase in DHEA level among acne-positive compared with acne-negative cases.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"159 1","pages":"1675 - 1679"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85352615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Farag, E. Badr, N. Fawzy, N. Elnaidany, Eman E. Zaher
Objective To measure levels of interleukin 8 (IL-8) in coronavirus disease 2019 (COVID-19)-infected patients with and without skin lesions in El-Bagour Hospital. Background Since the initial outbreak of COVID-19 in December of 2019, skin lesions have been a clinical sign of COVID-19. Hypercytokinemia (e.g. IL-8) has a vital role in the pathogenesis of COVID-19. Patients and methods This case–control study was done on 180 participants, including 60 COVID-19-infected patients having skin manifestations and 60 COVID-19-infected patients not having skin manifestations, besides 60 age-matched and sex-matched healthy participants as a control group. The participants comprised those attending El-Bagour Hospital COVID-19 isolation center from March 2020 to March 2021. The assay of IL-8 was done by the enzyme-linked immunosorbent assay technique. Results The mean value of IL-8 was markedly greater in COVID-19-infected patients than the controls (30.55 ± 48.70 vs. 1.85 ± 0.64 ng/ml). The mean value of IL-8 was significantly higher in COVID-19-infected patients with cutaneous manifestations than those without (52.49 ± 61.56 vs. 8.60 ± 3.65 ng/ml). Conclusion The mean value of IL-8 was markedly greater in COVID-19-infected patients, especially severe cases, than the controls and in COVID-19-infected patients with cutaneous manifestations than those without cutaneous manifestations. IL-8 serum value was an excellent marker for prediction of COVID-19-infected patients from the control group and for prediction of COVID-19-infected patients with skin lesions from those without skin lesions.
{"title":"Interleukin 8 serum level in coronavirus disease 2019-infected patients having skin lesions: a case–control study","authors":"A. Farag, E. Badr, N. Fawzy, N. Elnaidany, Eman E. Zaher","doi":"10.4103/mmj.mmj_282_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_282_22","url":null,"abstract":"Objective To measure levels of interleukin 8 (IL-8) in coronavirus disease 2019 (COVID-19)-infected patients with and without skin lesions in El-Bagour Hospital. Background Since the initial outbreak of COVID-19 in December of 2019, skin lesions have been a clinical sign of COVID-19. Hypercytokinemia (e.g. IL-8) has a vital role in the pathogenesis of COVID-19. Patients and methods This case–control study was done on 180 participants, including 60 COVID-19-infected patients having skin manifestations and 60 COVID-19-infected patients not having skin manifestations, besides 60 age-matched and sex-matched healthy participants as a control group. The participants comprised those attending El-Bagour Hospital COVID-19 isolation center from March 2020 to March 2021. The assay of IL-8 was done by the enzyme-linked immunosorbent assay technique. Results The mean value of IL-8 was markedly greater in COVID-19-infected patients than the controls (30.55 ± 48.70 vs. 1.85 ± 0.64 ng/ml). The mean value of IL-8 was significantly higher in COVID-19-infected patients with cutaneous manifestations than those without (52.49 ± 61.56 vs. 8.60 ± 3.65 ng/ml). Conclusion The mean value of IL-8 was markedly greater in COVID-19-infected patients, especially severe cases, than the controls and in COVID-19-infected patients with cutaneous manifestations than those without cutaneous manifestations. IL-8 serum value was an excellent marker for prediction of COVID-19-infected patients from the control group and for prediction of COVID-19-infected patients with skin lesions from those without skin lesions.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"66 1","pages":"1692 - 1696"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85559335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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