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Physical Fitness Tests in the Army-Legitimate Diversity or Randomness? 军队中的体能测试--合理的多样性还是随机性?
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usad504
Andrzej Tomczak

In this article, I present my views on the diversified approaches to assess the physical fitness of soldiers within selected armies worldwide. I discussed the related common features and paradoxes associated with these approaches. For the comparative analysis, national diversity was taken into account and subjective selection of the physical fitness tests conducted in the armies of the United States, Finland, Germany, India, China, Israel, Netherlands, Sweden, Switzerland, United Kingdom, and Poland was done. An analysis of the physical fitness tests reveals significant variations, despite the purpose of the assessment being the same, that is, to evaluate a soldier's physical preparedness for combat tasks. Based on the analysis, I categorize the variation in physical fitness tests of soldiers at four levels: (1) single-system function tests (e.g., push-ups, sit-ups) vs. multi-system tests (obstacle courses), (2) considering health aspects vs. not considering health aspects during physical fitness tests, (3) motor components vs. coordination components (e.g.,balance), and (4) tests differentiated by gender and age vs.tests not differentiated by gender and age. In conclusion, I am in favor of multi-system tests, comprised of obstacle courses mirroring potential situations in combat tasks. In my opinion, multi-system tests are superior compared to single-system function tests since they enable a comprehensive assessment of effort, coordination, and mental predispositions necessary for functioning in real-life conditions. I also support physical fitness evaluation that is not differentiated based on a soldier's gender and age, as there is no logical justification for such distinctions.

在这篇文章中,我就全球选定军队中评估士兵体能的多样化方法提出了自己的看法。我讨论了与这些方法相关的共同特征和悖论。在进行比较分析时,考虑到了国家的多样性,并对美国、芬兰、德国、印度、中国、以色列、荷兰、瑞典、瑞士、英国和波兰军队进行的体能测试进行了主观选择。对体能测试的分析表明,尽管评估的目的是相同的,即评估士兵执行作战任务的体能准备情况,但它们之间存在着很大的差异。根据分析,我将士兵体能测试的差异分为四个层次:(1) 单系统功能测试(如俯卧撑、仰卧起坐)与多系统测试(障碍赛);(2) 在体能测试中考虑健康因素与不考虑健康因素;(3) 运动部分与协调部分(如平衡);(4) 按性别和年龄区分的测试与不按性别和年龄区分的测试。总之,我赞成多系统测试,包括反映战斗任务中潜在情况的障碍课程。我认为,多系统测试优于单系统功能测试,因为多系统测试可以全面评估在现实条件下工作所需的努力、协调和心理倾向。我还支持不根据士兵的性别和年龄来区分体能评估,因为这种区分没有任何逻辑依据。
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引用次数: 0
Sex Differences in Screening Positive for Post-Traumatic Stress Disorder After Combat Injury. 战伤后筛查出创伤后应激障碍阳性结果的性别差异。
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usae050
Andrew J MacGregor, Amber L Dougherty, Daniel J Crouch, Judy L Dye

Introduction: U.S. military women were at risk of combat exposure and injury from asymmetric warfare during the conflicts in Iraq and Afghanistan. Previous research has yielded mixed results when examining sex differences in PTSD following operational deployment. To date, no study has explored sex differences in PTSD after combat injury.

Materials and methods: This retrospective study included U.S. military service men and women who experienced a combat injury in Iraq or Afghanistan (March 2003 to March 2013) and completed a Post-Deployment Health Assessment (PDHA) within 1 year of injury. The PDHA is administered at the end of deployment and includes the 4-item Primary Care PTSD Screen. The prevalence of screening positive for PTSD was evaluated by sex using a chi-square test. Multivariable logistic regression was used to assess the association between sex and PTSD while adjusting for covariates.

Results: The study sample included 16,215 injured military personnel (666 women and 15,549 men). The average time between injury and PDHA was 132 days (SD = 91.0). Overall, women had a higher prevalence of screening positive for PTSD than men (48.3% vs. 40.9%, P < .001). In multivariable regression, women had higher odds than men of screening positive for PTSD (odds ratio, 1.34; 95% confidence interval, 1.14-1.57). Psychiatric history was the strongest predictor of screening positive for PTSD regardless of sex (odds ratio, 1.59; 95% confidence interval, 1.45-1.74).

Conclusions: In this novel study of military service members, women were more likely to screen positive for PTSD than men after combat injury. Strategies to mitigate PTSD, enhance resiliency, and incorporate psychological care into injury rehabilitation programs for women may be needed for future U.S. military conflicts where they will play a larger role in combat operations.

导言:在伊拉克和阿富汗冲突期间,美军女兵有可能在战斗中受到非对称战争的伤害。以前的研究对作战部署后创伤后应激障碍的性别差异进行了研究,结果不一。迄今为止,还没有一项研究探讨了战伤后创伤后应激障碍的性别差异:这项回顾性研究包括在伊拉克或阿富汗经历过战斗伤害(2003 年 3 月至 2013 年 3 月)并在受伤后 1 年内完成部署后健康评估(PDHA)的美军男女军人。PDHA 在部署结束时进行,包括 4 个项目的初级保健创伤后应激障碍筛查。采用卡方检验对创伤后应激障碍筛查阳性率按性别进行评估。使用多变量逻辑回归评估性别与创伤后应激障碍之间的关系,同时调整协变量:研究样本包括 16,215 名受伤军人(666 名女性和 15,549 名男性)。受伤与 PDHA 之间的平均间隔时间为 132 天(SD = 91.0)。总体而言,女性的创伤后应激障碍筛查阳性率高于男性(48.3% 对 40.9%,P 结论:在这项针对军人的新颖研究中,女性比男性更有可能在战伤后筛查出创伤后应激障碍阳性。在未来的美军冲突中,女性将在作战行动中扮演更重要的角色,因此可能需要制定策略来减轻创伤后应激障碍、提高恢复能力,并将心理护理纳入女性伤后康复计划。
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引用次数: 0
A Conceptual Model of Individual Clinical Readiness. 个人临床准备的概念模型。
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usae215
Christopher A VanFosson
<p><strong>Introduction: </strong>Force readiness is a priority among senior leaders across all branches of the Department of Defense. Units that do not achieve readiness benchmarks are considered non-deployable until the unit achieves the requisite benchmarks. Because military units are made up of individuals, the unit cannot be ready if the individuals within the unit are not ready. For medical personnel, this refers to one's ability to competently provide patient care in a deployed setting or their individual clinical readiness (ICR). A review of the literature found no conceptual model of ICR. Other potential concepts, such as individual medical readiness, were identified but used inconsistently. Therefore, the purpose of this article is to define ICR and propose a conceptual model to inform future efforts to achieve ICR and facilitate future study of the concept.</p><p><strong>Materials and methods: </strong>Model development occurred using a 3-step theoretical model synthesis process. The process included specification of key concepts, identification of related factors and relationships, and organizing them into an integrated network of ideas.</p><p><strong>Results: </strong>ICR is the clinically oriented service members' (COSM) ability to meet the demands of the militarily relevant, assigned clinical mission. ICR leads to one's "individual clinical performance," a key concept distinct from ICR. To understand ICR, one must account for "individual characteristics," as well as one's "education," "training," and "exposure." ICR and individual clinical performance are influenced by the "quality of exposure" and the "patient care environment." One's "individual clinical performance" also reciprocally influences the patient care environment, as well as the "team's clinical performance." These factors (individual clinical performance, team clinical performance, and the patient care environment) influence "patient outcomes." In the proposed model, patient outcomes are an indirect result of ICR and its antecedents (personal characteristics, education, training, and exposure); one's individual clinical performance may not be consistent with their ICR. Patient outcomes are also influenced by the "patient environment" (external to the health care environment) and "patient characteristics"; these elements of the model do not influence ICR or individual clinical performance.</p><p><strong>Conclusion: </strong>Force readiness is a Department of Defense priority. In order for military units to be deployment ready, so too must their personnel be deployment ready. For COSMs, this includes one's ability to competently provide patient care in a deployed setting or their ICR. This article defines ICR, as well as identifies another key concept and other factors associated with ICR. The proposed model is a tool for military medical leaders to communicate with and influence non-medical military leaders in the Department of Defense. Future research is needed to fur
导言:部队战备状态是国防部各部门高层领导的首要任务。未达到战备基准的部队被视为不可部署,直到该部队达到必要的基准。因为军事单位是由个人组成的,如果单位内的个人没有做好准备,单位就不可能做好准备。对于医务人员来说,这是指一个人在部署环境中胜任提供病人护理的能力或其个人临床准备状态(ICR)。文献综述没有发现 ICR 的概念模型。其他潜在的概念,如个人医疗准备就绪,也有发现,但使用不一致。因此,本文旨在定义 ICR 并提出一个概念模型,为今后实现 ICR 的工作提供参考,并促进今后对这一概念的研究:模型的开发采用了三步理论模型综合流程。该过程包括明确关键概念、确定相关因素和关系,以及将它们组织成一个综合的思想网络:ICR 是指以临床为导向的服务人员(COSM)满足与军事相关的指定临床任务要求的能力。ICR 导致一个人的 "个人临床表现",这是一个有别于 ICR 的关键概念。要理解 ICR,就必须考虑 "个人特征 "以及个人的 "教育"、"培训 "和 "接触"。ICR 和个人临床表现受 "接触质量 "和 "病人护理环境 "的影响。个人的 "临床表现 "也会对病人护理环境以及 "团队的临床表现 "产生相互影响。这些因素(个人临床表现、团队临床表现和患者护理环境)会影响 "患者疗效"。在所提出的模型中,患者疗效是 ICR 及其前因(个人特征、教育、培训和接触)的间接结果;个人的临床表现可能与其 ICR 不一致。患者的治疗结果还受到 "患者环境"(医疗环境的外部因素)和 "患者特征 "的影响;模型中的这些因素不会影响 ICR 或个人临床表现:部队战备状态是国防部的首要任务。为了使军事单位做好部署准备,其人员也必须做好部署准备。对于 COSM 来说,这包括一个人在部署环境中胜任提供病人护理的能力或他们的 ICR。本文对 ICR 进行了定义,并指出了与 ICR 相关的另一个关键概念和其他因素。所提出的模型是军事医疗领导与国防部非医疗军事领导沟通并施加影响的工具。未来的研究需要进一步完善所提出的模型,确定所提出的关系的强度,并确定改善 ICR 的干预措施。
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引用次数: 0
Factors That Influence Health Care-Seeking Behavior and Health Information Disclosure Among U.S. Air Force Pilots. 影响美国空军飞行员寻求医疗保健行为和健康信息披露的因素。
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usae310
Tanya M Goodman, Rachael N Martinez, Nicole L Giarrusso, Christopher Thompson, William R Hoffman

Introduction: The reality of pilot health care avoidance behavior is often common knowledge to both pilots and aeromedical physicians, but the underlying factors leading to this behavior are less understood. In the current study, we conducted a qualitative assessment of a sample of U.S. Air Force (USAF) pilots to gather firsthand perceptions of the factors that encourage and discourage disclosure during aeromedical screening and use of mental and physical health care services, as well as recommendations to improve the USAF aeromedical health care system.

Materials and methods: We conducted interviews with 21 USAF pilots on their perceptions of seeking medical care to identify factors that uniquely discourage or encourage disclosure and health care utilization to understand factors that aid the aeromedical provider/aviator relationship and to elicit interventions that could be prospectively researched. This work was reviewed by the Air Force Research Laboratory Institutional Review Board at Wright-Patterson Air Force Base and designated as exempt research, FWR20220103E.

Results: The most reported factors that discourage military pilot health care disclosure and health care utilization overall were medical revocation, stigma, and lack of trust in providers. Unit-embedded services, ease of access, and severity of condition were the most reported factors encouraging disclosure and utilization. Factor descriptions and exemplary quotes from pilots and pilot recommendations to encourage health care utilization and disclosure are provided.

Conclusions: Results from firsthand interviews with pilots provide valuable information for flight surgeons to focus on building trust with their pilots to reduce health care avoidance.

导言:飞行员回避医疗保健行为的现实往往是飞行员和航空医疗医生的共识,但导致这种行为的潜在因素却鲜为人知。在目前的研究中,我们对美国空军(USAF)飞行员样本进行了定性评估,以收集他们对鼓励和阻止在航空医学检查期间披露信息、使用心理和身体保健服务的因素的第一手看法,以及改进美国空军航空医学保健系统的建议:我们对 21 名美国空军飞行员进行了访谈,了解他们对就医的看法,以确定阻碍或鼓励披露信息和使用医疗保健服务的独特因素,从而了解有助于航空医疗服务提供者与飞行员之间关系的因素,并提出可进行前瞻性研究的干预措施。这项工作已通过莱特-帕特森空军基地空军研究实验室机构审查委员会的审查,并被指定为豁免研究,编号为 FWR20220103E:结果:报告最多的阻碍军事飞行员披露医疗保健信息和利用医疗保健服务的因素是医疗撤销、耻辱感和对医疗服务提供者缺乏信任。据报告,鼓励披露和利用医疗服务的因素中最多的是单位嵌入式服务、就医方便性和病情严重程度。文中提供了飞行员的因素描述和典型引语,以及鼓励利用和披露医疗服务的飞行员建议:对飞行员的第一手访谈结果为飞行外科医生提供了宝贵的信息,有助于他们与飞行员建立信任,减少逃避医疗服务的现象。
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引用次数: 0
Young Man With Primary Mucinous Cell Carcinoma of the Eyelid: 36 Month Follow Up. 患有眼睑原发性黏液细胞癌的年轻人:36 个月的随访。
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usad477
Sama S Alazawi, Vienna G Katana

Primary cutaneous mucinous carcinoma (PCMC) is a malignant adnexal tumor that masquerades as a benign periocular lesion. We present a case of a 29-year-old male with an eyelid PCMC misdiagnosed as a chalazion. He underwent Mohs microscopic surgery for definitive treatment, with no recurrence at his 36 month follow up. Given the rarity and poorer prognosis in younger patients, a high index of suspicion is crucial for biopsying periocular lesions that fail conservative therapy.

原发性皮肤黏液癌(PCMC)是一种恶性附件肿瘤,可伪装成眼周良性病变。我们介绍了一例被误诊为霰粒肿的 29 岁男性眼睑原发性皮肤黏液癌病例。他接受了莫氏显微手术进行明确治疗,随访 36 个月未见复发。鉴于年轻患者的罕见性和较差的预后,在对保守治疗失败的眼周病变进行活检时,高度怀疑至关重要。
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引用次数: 0
Impact of a Mentorship Program to Prepare Medical Students for the Military Residency Match. 指导计划对医科学生参加军队住院医师培训的影响。
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usae168
David Boedeker, Kiley Hunkler, Samantha Strohm, Michael Zamani, Lindsay Chatfield, Rene MacKinnon, Katerina Shvartsman

Introduction: Mentorship programs have well-documented benefits to both mentees and mentors. Military medical students face unique challenges in medical school given their service-specific requirements and separate military match process. We therefore aimed to determine whether military medical students' participation in a mentorship program impacts their confidence in applying to obstetrics and gynecology (OB/GYN) residency.

Materials and methods: First, a needs assessment survey regarding the use of a mentorship program was sent to medical students, residents, fellows, and attendings. A structured mentorship program was then developed for military medical students applying to OB/GYN residency based on the survey results. Mentors were randomly paired with mentees and asked to appraise curriculum vitaes, review personal statements, and perform mock interviews. Following completion of these activities, participants were sent a post-intervention questionnaire. This project was exempt by our institution's Institutional Review Board.

Results: Our program had 56 participants, with 29 individuals completing our post-intervention survey (response rate 51.8%). After participating in the program, 92.3% of mentors stated they plan to continue a relationship with their mentee. All the mentee respondents stated they would participate in this program again. Before participating in the program, 16.7% of mentees felt "prepared" or "extremely prepared" for the match, compared to 87.6% post-intervention. Most mentee respondents (75%) reported that this program made them a more competitive applicant. Following the mentorship program, 66.7% of participants successfully matched into OB/GYN residency.

Conclusions: This reproducible, well-received intervention can be implemented to facilitate mentoring connections regardless of geographic location. As the OB/GYN specialty develops its own application process, civilian medical schools should consider adopting similar programs to aid their students in navigating the match process.

导言:导师计划对被指导者和指导者的益处有据可查。鉴于其服役的特定要求和单独的军事匹配过程,军医学生在医学院面临着独特的挑战。因此,我们旨在确定军医学生参加导师项目是否会影响他们申请妇产科住院医师的信心:首先,向医科学生、住院医师、研究员和主治医师发送了一份关于导师项目使用情况的需求评估调查。然后,根据调查结果为申请妇产科住院医师培训的军医学生制定了结构化导师计划。导师与被指导者随机配对,要求他们评估简历、审查个人陈述并进行模拟面试。完成这些活动后,参与者会收到一份干预后调查问卷。该项目获得了我校机构审查委员会的批准:我们的项目共有 56 名参与者,其中 29 人完成了干预后调查(回复率为 51.8%)。参加计划后,92.3% 的指导者表示他们计划继续与被指导者保持联系。所有被指导者都表示他们会再次参加该计划。在参与计划之前,16.7% 的被指导者认为自己为配对 "做好了准备 "或 "准备得非常充分",而在干预后,这一比例为 87.6%。大多数被指导者(75%)表示,该计划使他们成为更有竞争力的申请者。指导计划结束后,66.7% 的参与者成功申请到了妇产科住院医师职位:结论:这一可重复、广受好评的干预措施可用于促进指导联系,而不受地理位置的限制。随着妇产科专业制定了自己的申请程序,民用医学院校应考虑采用类似的计划,帮助他们的学生顺利通过匹配过程。
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引用次数: 0
A Linguistic Analysis of United States Navy Orthopaedic Surgery Applicant Personal Statements. 美国海军矫形外科申请人个人陈述的语言学分析。
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usae190
Reinaldo E Colon-Morillo, Nithya Chennupati, Trevor Tompane, Nicholas Healy, Cory Janney

Introduction: Despite the importance of linguistic analysis, no systematic research has been explored in the form of linguistic analysis on personal statements for military orthopedic surgery residency programs. This study was conducted to analyze U.S. Navy (USN) orthopedic surgery applicants' personal statements using an automated textual analysis program to assess personal statements for linguistic styles.

Methods: A retrospective analysis of USN orthopedic applicant personal statements from application years 2016 to 2019 was performed utilizing the Linguistic Inquiry and Word Count (LIWC) software. LIWC analyzed the text for summary variables: analytical thinking, clout, authenticity, and emotional tone. We compared this analysis with Step 1 and Step 2 scores and determined whether an applicant matched.

Results: A total of 94 personal statements (60,230 words) were analyzed using LIWC. The average word count was 640.7, with an average of 23 words per sentence. The average-matched applicant USMLE Step 1 and Step 2 scores were 240 and 250, respectively. When examining summary traits utilizing multiple logistic regression analysis, only analytical thinking demonstrated a statistically significant difference in matched versus unmatched applicants with a P = .011 (OR = 1.10).

Conclusion: As the USMLE Step 1 exam transitions from a scoring system to Pass/Fail grading, programs will look at other characteristics to determine who would likely succeed in residency. From a linguistic analysis standpoint, matched applicants' personal statements demonstrated higher analytical thinking, clout, affiliation, power, and risk focus than unmatched applicants. Unmatched applicants demonstrated higher authenticity than matched applicants.

导言:尽管语言分析非常重要,但目前还没有针对军事骨科外科住院医师项目个人陈述进行语言分析的系统研究。本研究使用自动文本分析程序对美国海军(USN)骨科手术申请者的个人陈述进行分析,以评估个人陈述的语言风格:利用语言调查和字数统计(LIWC)软件,对 2016 年至 2019 年美国海军骨科申请者的个人陈述进行了回顾性分析。LIWC分析了文本的摘要变量:分析性思维、影响力、真实性和情感基调。我们将分析结果与步骤 1 和步骤 2 分数进行比较,并确定申请人是否符合要求:使用 LIWC 分析了总共 94 篇个人陈述(60,230 字)。平均字数为 640.7,平均每句 23 个字。匹配申请人的 USMLE 第 1 步和第 2 步平均分数分别为 240 分和 250 分。在利用多元逻辑回归分析研究综合特质时,只有分析性思维在匹配申请人与非匹配申请人之间存在统计学意义上的显著差异,P = .011 (OR = 1.10):结论:随着 USMLE 第 1 步考试从计分系统过渡到及格/不及格分级,项目将通过其他特征来确定谁有可能在住院实习中取得成功。从语言分析的角度来看,配对申请人的个人陈述比非配对申请人表现出更高的分析性思维、影响力、从属关系、权力和风险关注。非配对申请人的真实性高于配对申请人。
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引用次数: 0
Effectiveness of In-Theater Mental Health Assessments. 剧场内心理健康评估的有效性。
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usae213
SarahLouise Perez, Hasan U Dimayuga, Kevin M Estrada, Adan Flores, Andrew B Hall

Introduction: The leading cause for medical evacuation from the U.S. Central Command area of responsibility is because of mental health conditions. The In-Theater Mental Health Assessment (ITMHA) is a DoD-required screening of deployed personnel. It is vital to examine the efficacy of ITMHA's potential to significantly impact the mental health outcomes of service members.

Materials and methods: All ITMHA results of individuals in 2 deployed Army battalions along with a brigade headquarters deployed to U.S. Central Command between October 2022 and October 2023 were collected and analyzed. Descriptive statistics were used to characterize the results of the ITMHA.

Results: Of 670 deployed service members, 157 (23%) scored positive on ITMHA. Ten service members were referred for additional mental health evaluation. The remaining 147 (22%) service members who scored positive were not referred because of a lack of significant impairment or were already engaged in mental health services. One service member in the study was evacuated because of a mental health condition. The most common major life stressors identified were family/relationship issues, sleep problems, and mental health concerns.

Conclusions: The number of deployed personnel identified through the ITMHA as requiring mental health care was modest. The ITMHA has multiple limitations that, if addressed, will improve its utility to mitigate mental health decline in the expeditionary environment.

导言:从美国中央司令部责任区医疗后送的主要原因是精神健康状况。战区内心理健康评估(ITMHA)是国防部要求对部署人员进行的筛查。研究 ITMHA 对服役人员心理健康结果产生重大影响的潜力至关重要:收集并分析了 2022 年 10 月至 2023 年 10 月期间部署到美国中央司令部的两个陆军营和一个旅司令部的所有 ITMHA 结果。描述性统计用于描述 ITMHA 结果的特征:在 670 名部署的军人中,157 人(23%)在 ITMHA 中得分呈阳性。有 10 名军人被转介接受额外的心理健康评估。其余 147 名(22%)得分呈阳性的服役人员没有被转诊,因为他们没有明显的损伤或已经接受了心理健康服务。研究中有一名军人因精神健康状况而撤离。最常见的主要生活压力是家庭/人际关系问题、睡眠问题和心理健康问题:通过 ITMHA 确认需要心理健康护理的部署人员数量不多。ITMHA 有许多局限性,如果能加以解决,将能提高其在远征环境中缓解心理健康下降的效用。
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引用次数: 0
Irritable Bowel Syndrome in Veterans With Gulf War Illness Evaluated at VA's War-Related Illness and Injury Study Center. 退伍军人事务部战争相关疾病和伤害研究中心对患有海湾战争疾病的退伍军人进行肠易激综合征评估。
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usae260
Alice B S Nono Djotsa, Theresa H Nguyen Wenker, Sarah T Ahmed, Saurendro Ghosh, Deeksha Malhotra, Stephen H Boyle, Elizabeth J Gifford, Kellie J Sims, Donna L White, Lea Steele, Drew A Helmer

Introduction: Excess rates of Gulf War illness (GWI) and irritable bowel syndrome (IBS), two chronic multisymptom illnesses, have long been documented among nearly 700,000 veterans who served in the 1990-1991 Persian Gulf War. We sought to report the prevalence, characteristics, and association of GWI and IBS decades after the war in a clinical cohort of deployed Gulf War veterans (GWVs) who were evaluated at the Department of Veterans Affairs' War Related Illness and Injury Study Center (WRIISC) for unexplained chronic symptoms.

Materials and methods: We analyzed data gathered from clinical intake questionnaires of deployed GWVs who were evaluated at WRIISC clinics between 2008 and 2020. We applied Centers for Disease Control (CDC) criteria to determine the prevalence of severe GWI. IBS was identified using Rome IV diagnostic criteria (current IBS) and veterans' self-reported "history of physician-diagnosed IBS." We examined associations between IBS and GWI using bivariate analyses and multivariable logistic regression.

Results: Among the N = 578 GWVs evaluated by the WRIISC, severe GWI (71.8%), history of physician-diagnosed IBS (50.3%) and current IBS (42.2%) were all highly prevalent. Nearly half of GWVs with severe GWI met Rome criteria for IBS (45.8%), and over half reported a history of physician-diagnosed IBS (56.1%). In multivariable models, severe GWI was significantly associated both with current IBS (adjusted odds ratio (aOR): 1.68, 95% CI: 1.11, 2.54) and with veteran-reported history of physician-diagnosed IBS (aOR: 2.15, 95% CI: 1.43, 2.23). IBS with diarrhea (IBS-D) was the most common subtype among GWVs with current IBS (61.1%). However, IBS-mixed affected a significantly greater proportion of veterans with severe GWI, compared to veterans who did not have severe GWI (P = .03).

Conclusions: More than 20 years after the Persian Gulf War, our findings indicate a high degree of comorbidity between severe GWI and IBS among deployed GWVs seeking care for unexplained illnesses. Our results suggest GWVs with GWI should be screened for IBS for which evidence-based treatments are available and could potentially reduce symptom burden. Conversely, symptoms of IBS should trigger additional evaluation for non-gastrointestinal symptoms in deployed Gulf War veterans to identify possible GWI and ensure a comprehensive approach to care.

导言:在 1990-1991 年波斯湾战争中服役的近 70 万名退伍军人中,海湾战争病(GWI)和肠易激综合征(IBS)这两种慢性多症状疾病的发病率一直居高不下。我们试图报告战后数十年,在退伍军人事务部战争相关疾病和伤害研究中心(WRIISC)接受不明原因慢性症状评估的海湾战争退伍军人(GWVs)临床队列中,GWI 和 IBS 的患病率、特征和关联性:我们分析了 2008 年至 2020 年期间在 WRIISC 诊所接受评估的已部署退伍军人的临床入院问卷调查数据。我们采用美国疾病控制中心 (CDC) 的标准来确定严重 GWI 的患病率。肠易激综合征是根据罗马 IV 诊断标准(当前肠易激综合征)和退伍军人自我报告的 "医生诊断肠易激综合征病史 "确定的。我们通过双变量分析和多变量逻辑回归研究了肠易激综合征与 GWI 之间的关系:结果:在接受 WRIISC 评估的 N = 578 名 GWV 中,严重 GWI(71.8%)、医生诊断的肠易激综合征病史(50.3%)和当前肠易激综合征(42.2%)的发病率都很高。近一半有严重 GWI 的 GWV 符合罗马肠易激综合征标准(45.8%),超过一半的 GWV 报告有医生诊断的肠易激综合征病史(56.1%)。在多变量模型中,严重 GWI 与当前肠易激综合征(调整赔率 (aOR):1.68,95% CI:1.11, 2.54)和退伍军人报告的医生诊断肠易激综合征病史(aOR:2.15,95% CI:1.43, 2.23)均有显著相关性。在目前患有肠易激综合征的退伍军人中,肠易激综合征伴腹泻(IBS-D)是最常见的亚型(61.1%)。然而,与没有严重GWI的退伍军人相比,患有严重GWI的退伍军人中患混合型肠易激综合征的比例明显更高(P = .03):结论:在波斯湾战争结束 20 多年后,我们的研究结果表明,在因不明原因疾病就医的已部署 GWV 中,严重 GWI 和肠易激综合征的合并率很高。我们的研究结果表明,有 GWI 的 GWV 应接受肠易激综合征筛查,目前已有循证治疗方法,有可能减轻症状负担。相反,肠易激综合征的症状应引发对已部署的海湾战争退伍军人非胃肠道症状的额外评估,以识别可能的 GWI 并确保采取全面的护理方法。
{"title":"Irritable Bowel Syndrome in Veterans With Gulf War Illness Evaluated at VA's War-Related Illness and Injury Study Center.","authors":"Alice B S Nono Djotsa, Theresa H Nguyen Wenker, Sarah T Ahmed, Saurendro Ghosh, Deeksha Malhotra, Stephen H Boyle, Elizabeth J Gifford, Kellie J Sims, Donna L White, Lea Steele, Drew A Helmer","doi":"10.1093/milmed/usae260","DOIUrl":"10.1093/milmed/usae260","url":null,"abstract":"<p><strong>Introduction: </strong>Excess rates of Gulf War illness (GWI) and irritable bowel syndrome (IBS), two chronic multisymptom illnesses, have long been documented among nearly 700,000 veterans who served in the 1990-1991 Persian Gulf War. We sought to report the prevalence, characteristics, and association of GWI and IBS decades after the war in a clinical cohort of deployed Gulf War veterans (GWVs) who were evaluated at the Department of Veterans Affairs' War Related Illness and Injury Study Center (WRIISC) for unexplained chronic symptoms.</p><p><strong>Materials and methods: </strong>We analyzed data gathered from clinical intake questionnaires of deployed GWVs who were evaluated at WRIISC clinics between 2008 and 2020. We applied Centers for Disease Control (CDC) criteria to determine the prevalence of severe GWI. IBS was identified using Rome IV diagnostic criteria (current IBS) and veterans' self-reported \"history of physician-diagnosed IBS.\" We examined associations between IBS and GWI using bivariate analyses and multivariable logistic regression.</p><p><strong>Results: </strong>Among the N = 578 GWVs evaluated by the WRIISC, severe GWI (71.8%), history of physician-diagnosed IBS (50.3%) and current IBS (42.2%) were all highly prevalent. Nearly half of GWVs with severe GWI met Rome criteria for IBS (45.8%), and over half reported a history of physician-diagnosed IBS (56.1%). In multivariable models, severe GWI was significantly associated both with current IBS (adjusted odds ratio (aOR): 1.68, 95% CI: 1.11, 2.54) and with veteran-reported history of physician-diagnosed IBS (aOR: 2.15, 95% CI: 1.43, 2.23). IBS with diarrhea (IBS-D) was the most common subtype among GWVs with current IBS (61.1%). However, IBS-mixed affected a significantly greater proportion of veterans with severe GWI, compared to veterans who did not have severe GWI (P = .03).</p><p><strong>Conclusions: </strong>More than 20 years after the Persian Gulf War, our findings indicate a high degree of comorbidity between severe GWI and IBS among deployed GWVs seeking care for unexplained illnesses. Our results suggest GWVs with GWI should be screened for IBS for which evidence-based treatments are available and could potentially reduce symptom burden. Conversely, symptoms of IBS should trigger additional evaluation for non-gastrointestinal symptoms in deployed Gulf War veterans to identify possible GWI and ensure a comprehensive approach to care.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bronchoalveolar Lavage and Oleic Acid Two-hit Model for Inducing Acute Respiratory Distress Syndrome in Swine Models. 诱发猪急性呼吸窘迫综合征的支气管肺泡灌流和油酸双击模型
IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1093/milmed/usae191
Christopher Russo, Andrew Evans, Cameron Sullivan, Kayla Wands, Arlene Hudson, Peter Bedocs

Introduction: Acute respiratory distress syndrome (ARDS) is a widespread and often fatal clinical syndrome marked by the acute onset of pulmonary edema and inflammatory-mediated disruptions in alveolar-capillary permeability resulting in impaired gas exchange and tissue oxygenation with subsequent acute respiratory failure that accounts for 10.4% of all intensive care unit admissions worldwide and boasts a mortality rate of 38.5%. The current treatment for ARDS remains largely supportive. This is largely because of the many challenges of achieving a stable and sustainable animal model that recreates the pathophysiology of ARDS experimentally in a controlled setting to allow research to elucidate potential treatments of ARDS moving forward.

Materials and methods: The bronchoalveolar lavage and oleic acid models are currently the 2 most frequently used experimental models in inducing ARDS in animal models. This study demonstrated that combining them into a "two-hit model" can produce sustained ARDS in swine models per the Horowitz index (PaO2/FiO2 ratio of ≤300 mmHg). Additionally, expected changes in pH, pCO2, lung compliance, cytokines, and tissue histopathology were observed and add to our confidence and reliability that the "two-hit model" produces symptomatic ARDS in a manner very similar to that observed in humans.

Results and conclusions: In conclusion, we demonstrated a viable animal model of human ARDS that is maintained for a prolonged period, suitable for continuous monitoring of the progression, and evaluation of potential future treatments and procedures to reduce patient morbidity and mortality. To carry out this two-hit model, lung injury was induced through a combination of bronchoalveolar lavage and oleic acid administration and the disease process of ARDS is subsequently tracked through clinically relevant parameters such as respiratory mechanics, cytokine response, aretrial blood gas (ABG) changes, and observation of postmortem histopathologic changes. This promising new model has the capacity to successfully replicate human ARDS which is a well-known and notoriously multifactorial pathogenic process to reproduce experimentally for an extended period of time. The "two-hit model" is a viable and appropriate model for the research of novel treatments for ARDS.

简介急性呼吸窘迫综合征(ARDS)是一种广泛存在且往往致命的临床综合征,其特征是急性发作的肺水肿和炎症介导的肺泡-毛细血管通透性破坏,导致气体交换和组织氧合功能受损,继而引发急性呼吸衰竭,占全球所有重症监护病房住院人数的 10.4%,死亡率高达 38.5%。目前对 ARDS 的治疗仍以支持性治疗为主。这主要是因为要建立一个稳定、可持续的动物模型,在受控环境中通过实验重现 ARDS 的病理生理学,以便研究阐明 ARDS 的潜在治疗方法,还面临着许多挑战:支气管肺泡灌洗模型和油酸模型是目前在动物模型中诱导 ARDS 最常用的两种实验模型。本研究表明,根据霍洛维茨指数(PaO2/FiO2 比率≤300 mmHg),将这两种模型结合成 "两击模型 "可在猪模型中产生持续的 ARDS。此外,我们还观察到 pH 值、pCO2、肺顺应性、细胞因子和组织病理学的预期变化,这增加了我们的信心和可靠性,即 "两击模型 "产生症状性 ARDS 的方式与在人类身上观察到的非常相似:总之,我们展示了一种可行的人类 ARDS 动物模型,该模型可长期保持,适合持续监测进展情况,并评估未来可能的治疗方法和程序,以降低患者的发病率和死亡率。为了建立这种两击模型,我们通过支气管肺泡灌洗和油酸给药相结合的方法诱发肺损伤,随后通过呼吸力学、细胞因子反应、试验血气(ABG)变化等临床相关参数跟踪 ARDS 的疾病过程,并观察死后组织病理学变化。这一前景广阔的新模型有能力成功复制人类 ARDS,而 ARDS 是一种众所周知的多因素致病过程,难以在实验中长时间复制。两击模型 "是研究 ARDS 新型疗法的可行且合适的模型。
{"title":"Bronchoalveolar Lavage and Oleic Acid Two-hit Model for Inducing Acute Respiratory Distress Syndrome in Swine Models.","authors":"Christopher Russo, Andrew Evans, Cameron Sullivan, Kayla Wands, Arlene Hudson, Peter Bedocs","doi":"10.1093/milmed/usae191","DOIUrl":"10.1093/milmed/usae191","url":null,"abstract":"<p><strong>Introduction: </strong>Acute respiratory distress syndrome (ARDS) is a widespread and often fatal clinical syndrome marked by the acute onset of pulmonary edema and inflammatory-mediated disruptions in alveolar-capillary permeability resulting in impaired gas exchange and tissue oxygenation with subsequent acute respiratory failure that accounts for 10.4% of all intensive care unit admissions worldwide and boasts a mortality rate of 38.5%. The current treatment for ARDS remains largely supportive. This is largely because of the many challenges of achieving a stable and sustainable animal model that recreates the pathophysiology of ARDS experimentally in a controlled setting to allow research to elucidate potential treatments of ARDS moving forward.</p><p><strong>Materials and methods: </strong>The bronchoalveolar lavage and oleic acid models are currently the 2 most frequently used experimental models in inducing ARDS in animal models. This study demonstrated that combining them into a \"two-hit model\" can produce sustained ARDS in swine models per the Horowitz index (PaO2/FiO2 ratio of ≤300 mmHg). Additionally, expected changes in pH, pCO2, lung compliance, cytokines, and tissue histopathology were observed and add to our confidence and reliability that the \"two-hit model\" produces symptomatic ARDS in a manner very similar to that observed in humans.</p><p><strong>Results and conclusions: </strong>In conclusion, we demonstrated a viable animal model of human ARDS that is maintained for a prolonged period, suitable for continuous monitoring of the progression, and evaluation of potential future treatments and procedures to reduce patient morbidity and mortality. To carry out this two-hit model, lung injury was induced through a combination of bronchoalveolar lavage and oleic acid administration and the disease process of ARDS is subsequently tracked through clinically relevant parameters such as respiratory mechanics, cytokine response, aretrial blood gas (ABG) changes, and observation of postmortem histopathologic changes. This promising new model has the capacity to successfully replicate human ARDS which is a well-known and notoriously multifactorial pathogenic process to reproduce experimentally for an extended period of time. The \"two-hit model\" is a viable and appropriate model for the research of novel treatments for ARDS.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Military Medicine
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