首页 > 最新文献

Military Medicine最新文献

英文 中文
Pilonidal Disease: A Recent Decade of the Disease among Active Duty United States Military Service Members. 毛线虫病:最近十年美国现役军人中的疾病。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-03 DOI: 10.1093/milmed/usag015
Dylan M Griffiths, Meg I Robinson, Amber L Dougherty, Laura S Kraemer, Andrew J Macgregor, James D Wallace, Diego A Vicente, Christian S Mcevoy

Introduction: Sacrococcygeal pilonidal disease (PD) is a common surgical problem in the U.S. Military. Despite recent advancements, treatment strategies remain heterogenous and incompletely described, particularly among the active duty component in the Military Health System (MHS). This study's objectives were to identify the burden of PD and describe current healthcare utilization and treatment patterns in the MHS during a recent 10-year study period.

Materials and methods: The study population included all active duty U.S. service members with at least one PD diagnosis in the MHS Data Repository between January 1, 2013, and December 31, 2022. For each patient, the first PD diagnosis during the study period was the incident case, and a subsequent case was defined as a second PD diagnosis >30 days after the first and categorized as recurrent (procedure performed at incident encounter) or persistent (no procedure performed at incident encounter). Procedures were identified by Current Procedural Terminology codes.

Results: During the study period, 25,039 active duty service members were diagnosed with an incident case of PD. The study population was mostly male, less than 30 years old, enlisted, and in the Army or Navy. The overall incidence rate was 1.7 per 1,000 person-years. Prevalence of recurrence was 44.6% (2,494 of 5,598) and persistence was 50.1% (9,731 of 19,441). Overall, there were 115,387 medical encounters with a PD diagnosis during the study period, and service members in the top 25% for healthcare utilization had ≥11 encounters with a PD diagnosis.

Conclusions: Pilonidal disease imposes a significant burden on the MHS and is a threat to overall force medical readiness. Treatment strategies remain heterogeneous, and prospective studies are needed to refine clinical guidelines.

简介:骶尾骨毛突病(PD)是美国军队常见的外科问题。尽管最近取得了进展,但治疗策略仍然是异质的,描述不完整,特别是在军事卫生系统(MHS)的现役成分中。本研究的目的是确定PD的负担,并描述MHS在最近10年的研究期间当前的医疗保健利用和治疗模式。材料和方法:研究人群包括2013年1月1日至2022年12月31日期间在MHS数据存储库中至少有一次PD诊断的所有美国现役军人。对于每个患者,在研究期间的第一次PD诊断为偶发病例,随后的病例被定义为第一次PD诊断后30天的第二次PD诊断,并被分类为复发性(在偶发事件中进行手术)或持续性(在偶发事件中未进行手术)。程序由现行程序术语代码确定。结果:在研究期间,25,039名现役军人被诊断为PD事件病例。研究人群主要是男性,年龄在30岁以下,在陆军或海军服役。总发病率为每1000人年1.7例。复发率为44.6%(5598例中2494例),持续性为50.1%(19441例中9731例)。总体而言,在研究期间有115,387次PD诊断的医疗就诊,医疗保健利用率最高的25%的服务人员有≥11次PD诊断。结论:毛鞘疾病给MHS带来了巨大的负担,并威胁到整体部队的医疗准备。治疗策略仍然不同,需要前瞻性研究来完善临床指南。
{"title":"Pilonidal Disease: A Recent Decade of the Disease among Active Duty United States Military Service Members.","authors":"Dylan M Griffiths, Meg I Robinson, Amber L Dougherty, Laura S Kraemer, Andrew J Macgregor, James D Wallace, Diego A Vicente, Christian S Mcevoy","doi":"10.1093/milmed/usag015","DOIUrl":"https://doi.org/10.1093/milmed/usag015","url":null,"abstract":"<p><strong>Introduction: </strong>Sacrococcygeal pilonidal disease (PD) is a common surgical problem in the U.S. Military. Despite recent advancements, treatment strategies remain heterogenous and incompletely described, particularly among the active duty component in the Military Health System (MHS). This study's objectives were to identify the burden of PD and describe current healthcare utilization and treatment patterns in the MHS during a recent 10-year study period.</p><p><strong>Materials and methods: </strong>The study population included all active duty U.S. service members with at least one PD diagnosis in the MHS Data Repository between January 1, 2013, and December 31, 2022. For each patient, the first PD diagnosis during the study period was the incident case, and a subsequent case was defined as a second PD diagnosis >30 days after the first and categorized as recurrent (procedure performed at incident encounter) or persistent (no procedure performed at incident encounter). Procedures were identified by Current Procedural Terminology codes.</p><p><strong>Results: </strong>During the study period, 25,039 active duty service members were diagnosed with an incident case of PD. The study population was mostly male, less than 30 years old, enlisted, and in the Army or Navy. The overall incidence rate was 1.7 per 1,000 person-years. Prevalence of recurrence was 44.6% (2,494 of 5,598) and persistence was 50.1% (9,731 of 19,441). Overall, there were 115,387 medical encounters with a PD diagnosis during the study period, and service members in the top 25% for healthcare utilization had ≥11 encounters with a PD diagnosis.</p><p><strong>Conclusions: </strong>Pilonidal disease imposes a significant burden on the MHS and is a threat to overall force medical readiness. Treatment strategies remain heterogeneous, and prospective studies are needed to refine clinical guidelines.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intended and Unintended Pregnancies: Social Determinants and Pregnancy Mental Health from a Decade of Military Research. 有意怀孕和意外怀孕:十年军事研究中的社会决定因素和怀孕心理健康。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-02 DOI: 10.1093/milmed/usaf648
Monica A Lutgendorf, Katherine C Walker-Rodriquez, Tony T Yuan, Wenyaw C Chan, Karen L Weis

Introduction: Unintended pregnancy is linked to maternal depression, substance use, late prenatal care, low birthweight, and preterm birth. Our objective was to examine the incidence of unintended pregnancies in the military, the effects on maternal mental health and the effects of Social Determinants of Health (SDOH).

Materials and methods: This was an institutional research board-approved secondary analysis of two independent military datasets of pregnant individuals participating in two prospective clinical trials of a pregnancy mentorship program, collected 2012-2017 (n = 246) and 2018-2022 (n = 1,523), and compared to assess relationships of SDOH and maternal mental health measures for those with and without intended pregnancies.

Results: The rate of unintended pregnancy reported by participants was higher, 42.8% in 2012-2017 compared to 34.4% in 2018-2022. The rates of unintended pregnancy in both periods were lower than the national average and was lower in the second study period compared to the first. There were significantly higher scores for both anxiety and depression for those with unintended pregnancies, regardless of the sample. Over the same periods, the perception of support (as measured by the social support index) was higher in 2012-2017 compared to 2018-2022. Although the measures do not significantly differ by age, military branch, or rank, there was a significant relationship between the level of education and a lower rate of unintended pregnancy.

Conclusion: Exploration of Military Health System pregnancy data is important as it provides one of the best pictures of family and force readiness. The recent issue of unintended pregnancy and the increasing incidence of depression and anxiety, with lowered perceived support have long-term implications for the overall health and well-being of the U.S. military force, which demands continued investigation.

意外怀孕与母亲抑郁、药物使用、产前护理晚、低出生体重和早产有关。我们的目的是调查军队中意外怀孕的发生率、对产妇心理健康的影响以及健康的社会决定因素(SDOH)的影响。材料和方法:这是一项机构研究委员会批准的二次分析,收集了2012-2017年(n = 246)和2018-2022年(n = 1523)参加怀孕指导计划的两项前瞻性临床试验的孕妇的两个独立军事数据集,并比较了SDOH与有意怀孕和非有意怀孕的孕产妇心理健康措施的关系。结果:参与者报告的意外怀孕率更高,2012-2017年为42.8%,而2018-2022年为34.4%。这两个时期的意外怀孕率都低于全国平均水平,第二个研究期间的意外怀孕率比第一个研究期间的意外怀孕率低。无论样本是什么,意外怀孕的女性在焦虑和抑郁方面的得分都明显更高。在同一时期,与2018-2022年相比,2012-2017年对支持的感知(以社会支持指数衡量)更高。虽然这些措施在年龄、军种或军衔方面没有显著差异,但教育水平与较低的意外怀孕率之间存在显著关系。结论:探索军队卫生系统妊娠数据是重要的,因为它提供了家庭和部队准备的最佳图片之一。最近意外怀孕、抑郁和焦虑发生率的增加,以及感知支持度的降低,对美国军队的整体健康和福祉产生了长期影响,这需要继续调查。
{"title":"Intended and Unintended Pregnancies: Social Determinants and Pregnancy Mental Health from a Decade of Military Research.","authors":"Monica A Lutgendorf, Katherine C Walker-Rodriquez, Tony T Yuan, Wenyaw C Chan, Karen L Weis","doi":"10.1093/milmed/usaf648","DOIUrl":"https://doi.org/10.1093/milmed/usaf648","url":null,"abstract":"<p><strong>Introduction: </strong>Unintended pregnancy is linked to maternal depression, substance use, late prenatal care, low birthweight, and preterm birth. Our objective was to examine the incidence of unintended pregnancies in the military, the effects on maternal mental health and the effects of Social Determinants of Health (SDOH).</p><p><strong>Materials and methods: </strong>This was an institutional research board-approved secondary analysis of two independent military datasets of pregnant individuals participating in two prospective clinical trials of a pregnancy mentorship program, collected 2012-2017 (n = 246) and 2018-2022 (n = 1,523), and compared to assess relationships of SDOH and maternal mental health measures for those with and without intended pregnancies.</p><p><strong>Results: </strong>The rate of unintended pregnancy reported by participants was higher, 42.8% in 2012-2017 compared to 34.4% in 2018-2022. The rates of unintended pregnancy in both periods were lower than the national average and was lower in the second study period compared to the first. There were significantly higher scores for both anxiety and depression for those with unintended pregnancies, regardless of the sample. Over the same periods, the perception of support (as measured by the social support index) was higher in 2012-2017 compared to 2018-2022. Although the measures do not significantly differ by age, military branch, or rank, there was a significant relationship between the level of education and a lower rate of unintended pregnancy.</p><p><strong>Conclusion: </strong>Exploration of Military Health System pregnancy data is important as it provides one of the best pictures of family and force readiness. The recent issue of unintended pregnancy and the increasing incidence of depression and anxiety, with lowered perceived support have long-term implications for the overall health and well-being of the U.S. military force, which demands continued investigation.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Critical Look at the Challenges of Conducting de-Identified Military Surveys. 对开展去身份化军事调查的挑战的批判性审视。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-31 DOI: 10.1093/milmed/usaf633
Maegan M Paxton Willing, Jaime Rodden, Ariana R Bazzi, Sebastian Preilipper, Linda Thompson

Survey research has long been a cornerstone of behavioral health and medical research. With the growth of Internet-based survey platforms, accelerated by the COVID-19 pandemic, conducting surveys completely online has become the standard. Online surveys provide the field with a fast, cost-effective method for gaining insights into relationships among health variables or in obtaining preliminary data to inform larger-scale studies. Additionally, online surveys enable researchers to recruit from a larger geographical area, thus increasing the generalizability of findings and, importantly, allowing participants to complete study activities completely de-identified. Although participating anonymously can increase one's comfort with disclosing sensitive or stigmatizing information, this can pose significant challenges to ensuring the legitimacy of participants' eligibility. This may be particularly true when compensation is available, increasing the likelihood of a prospective participant falsely reporting characteristics such as current or former military service. The following commentary provides an overview of the current landscape for researchers conducting military-related research via online surveys, with a specific emphasis on challenges in ensuring participants have a military background. In support of this, we present several real-world challenges for conducting de-identified online surveys, such as difficulties ensuring participants have a military background and preventing the use of "bots." Additionally, the evolving challenge of artificial intelligence is discussed in the context of its impact on knowledge-based screening methods such as the Military Screener Questionnaire. Alternative approaches, such as compensated screening surveys, are presented. Surveys will continue to be an important tool for advancing military medical research; however, researchers must discuss findings within the context of the inherent limitations of the methodology. The field should carefully monitor the evolving challenges to conducting online surveys.

长期以来,调查研究一直是行为健康和医学研究的基石。随着互联网调查平台的发展,在新冠肺炎疫情的加速下,完全在线进行调查已成为标准。在线调查为该领域提供了一种快速、具有成本效益的方法,可以深入了解健康变量之间的关系,或获得初步数据,为更大规模的研究提供信息。此外,在线调查使研究人员能够从更大的地理区域招募,从而增加了研究结果的普遍性,重要的是,允许参与者完全去识别地完成研究活动。尽管匿名参与可以增加人们对披露敏感或污名化信息的舒适感,但这可能对确保参与者资格的合法性构成重大挑战。在有补偿的情况下尤其如此,这增加了潜在参与者谎报当前或以前服兵役等特征的可能性。以下评论概述了通过在线调查进行军事相关研究的研究人员的现状,特别强调了确保参与者具有军事背景方面的挑战。为了支持这一点,我们提出了进行去身份化在线调查的几个现实挑战,例如确保参与者具有军事背景和防止使用“机器人”的困难。此外,在其对基于知识的筛选方法(如军事筛选问卷)的影响的背景下讨论了人工智能不断发展的挑战。提出了替代方法,如有偿筛选调查。调查将继续是推进军事医学研究的重要工具;然而,研究人员必须在方法论固有局限性的背景下讨论研究结果。该领域应仔细监测开展在线调查的不断变化的挑战。
{"title":"A Critical Look at the Challenges of Conducting de-Identified Military Surveys.","authors":"Maegan M Paxton Willing, Jaime Rodden, Ariana R Bazzi, Sebastian Preilipper, Linda Thompson","doi":"10.1093/milmed/usaf633","DOIUrl":"https://doi.org/10.1093/milmed/usaf633","url":null,"abstract":"<p><p>Survey research has long been a cornerstone of behavioral health and medical research. With the growth of Internet-based survey platforms, accelerated by the COVID-19 pandemic, conducting surveys completely online has become the standard. Online surveys provide the field with a fast, cost-effective method for gaining insights into relationships among health variables or in obtaining preliminary data to inform larger-scale studies. Additionally, online surveys enable researchers to recruit from a larger geographical area, thus increasing the generalizability of findings and, importantly, allowing participants to complete study activities completely de-identified. Although participating anonymously can increase one's comfort with disclosing sensitive or stigmatizing information, this can pose significant challenges to ensuring the legitimacy of participants' eligibility. This may be particularly true when compensation is available, increasing the likelihood of a prospective participant falsely reporting characteristics such as current or former military service. The following commentary provides an overview of the current landscape for researchers conducting military-related research via online surveys, with a specific emphasis on challenges in ensuring participants have a military background. In support of this, we present several real-world challenges for conducting de-identified online surveys, such as difficulties ensuring participants have a military background and preventing the use of \"bots.\" Additionally, the evolving challenge of artificial intelligence is discussed in the context of its impact on knowledge-based screening methods such as the Military Screener Questionnaire. Alternative approaches, such as compensated screening surveys, are presented. Surveys will continue to be an important tool for advancing military medical research; however, researchers must discuss findings within the context of the inherent limitations of the methodology. The field should carefully monitor the evolving challenges to conducting online surveys.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Military Exposures Research: A State-of-the-Art Review. 军事暴露研究:最新进展综述。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-31 DOI: 10.1093/milmed/usaf647
Rachel T Wright, Jacob B Lindheimer, Israel C Christie, Jaraad Ramkissoon, Shaili Bhavsar, Rosalinda Desrochers, Walter W Frauman, Drew A Helmer
<p><strong>Introduction: </strong>Military personnel encounter a wide range of environmental and occupational exposures during their service such as burn pit smoke, chemical warfare agents, depleted uranium, jet fuel, radiation, and pesticides. The field of military exposures research seeks to better understand the nature of these exposures and their effects on Veteran and service member health. This state-of-the-art review assesses the breadth and depth of published military exposures research so that stakeholders can identify trends and gaps in this growing field.</p><p><strong>Materials and methods: </strong>An evidence mapping approach was used to perform a literature review of military exposures research published from 1962 to 2024. The search strategy was developed around exposed cohorts: groups of military personnel with a shared potential for exposure to toxic agents. Publications were included if they directly addressed exposures or related health outcomes in military cohorts. Publications were then further categorized by the type of research, and the results were analyzed to build a map of the current military exposures research landscape.</p><p><strong>Results: </strong>Thirty-six exposed cohorts were identified in the literature which were then grouped based on the nature of the exposure event: Wars and Operations (4 cohorts), Occupational Exposures (5), Combat and Combat Training (2), Across Military (2), Ship Exposures (2), Defense Testing (2), Base/Garrison Exposures (9), Toxic Substance Clean-Up and Disposal (5), and Isolated Exposure Events (5). The search identified 2,321 publications that fit the review inclusion criteria. The exposed cohort with the highest number of publications was Gulf War (940, 40.5% of all publications) followed by Vietnam War (277, 11.9%), Post-9/11 Operations in Iraq and Afghanistan (191, 8.2%), Aircraft Mechanics and Ground Support (176, 7.6%), and Munition Emissions and Embedded Fragments (164, 7.1%). Each remaining cohort individually represented < 4% of the literature. Six cohorts appeared only in non-peer-reviewed reports. The type of research best represented was Epidemiology (34.0%) followed by Animal and In Vitro Models (18.8%), Sequelae and Management (17.1%), Reviews and Meta-Analyses (11.7%), Exposure Assessment (9.5%), Toxic Agent Sampling and Analysis (4.3%), and publications from the National Academy of Sciences, Engineering, and Medicine (4.6%). The volume of military exposures research has increased steadily since the early public reports of Gulf War Illness in 1994, with 50% of articles being published after 2008.</p><p><strong>Conclusion: </strong>Military exposures research published since 1962 has focused on cohorts from large, high-profile deployments, particularly the Gulf War. Underrepresented cohorts with potential exposures on bases or from military occupations present opportunities for future research. The lack of meaningful exposure assessment data that has been published also
简介:军事人员在服役期间会遇到各种各样的环境和职业暴露,如燃烧坑烟雾、化学战剂、贫铀、喷气燃料、辐射和农药。军事暴露研究领域旨在更好地了解这些暴露的性质及其对退伍军人和服务人员健康的影响。这项最新的审查评估了已发表的军事暴露研究的广度和深度,以便利益攸关方能够确定这一不断发展的领域的趋势和差距。材料和方法:采用证据映射方法对1962年至2024年发表的军事暴露研究进行文献综述。搜索策略是围绕暴露队列制定的:暴露于有毒物质的共同潜力的军事人员群体。如果出版物直接涉及军人群体的接触或相关健康结果,则列入其中。然后根据研究类型对出版物进行进一步分类,并对结果进行分析,以构建当前军事暴露研究景观的地图。结果:在文献中确定了36个暴露队列,然后根据暴露事件的性质进行分组:战争和行动(4个队列),职业暴露(5个),战斗和战斗训练(2个),跨军事(2个),船舶暴露(2个),防御测试(2个),基地/驻军暴露(9个),有毒物质清理和处置(5个)和孤立暴露事件(5个)。检索确定了2321篇符合综述纳入标准的出版物。发表数量最多的暴露队列是海湾战争(940,占所有出版物的40.5%),其次是越南战争(277,占11.9%),伊拉克和阿富汗的9/11后行动(191,占8.2%),飞机机械和地面支援(176,占7.6%),弹药排放和嵌入碎片(164,占7.1%)。每个剩余队列单独代表< 4%的文献。六个队列只出现在非同行评议的报告中。最具代表性的研究类型是流行病学(34.0%),其次是动物和体外模型(18.8%)、后遗症和管理(17.1%)、综述和荟萃分析(11.7%)、暴露评估(9.5%)、有毒物质抽样和分析(4.3%),以及来自美国国家科学院、工程和医学院的出版物(4.6%)。自1994年海湾战争疾病的早期公开报告以来,军事暴露研究的数量稳步增加,其中50%的文章是在2008年之后发表的。结论:自1962年以来发表的军事暴露研究主要集中在大规模,高调部署的队列,特别是海湾战争。在基地或军事职业中有潜在暴露的未充分代表的队列为未来的研究提供了机会。缺乏已发表的有意义的暴露评估数据也指出了进一步研究的机会,以具体改善暴露数据的收集和可及性。这项工作应该把重点放在研究可以直接影响退伍军人获得福利和暴露知情护理的群体上。
{"title":"Military Exposures Research: A State-of-the-Art Review.","authors":"Rachel T Wright, Jacob B Lindheimer, Israel C Christie, Jaraad Ramkissoon, Shaili Bhavsar, Rosalinda Desrochers, Walter W Frauman, Drew A Helmer","doi":"10.1093/milmed/usaf647","DOIUrl":"10.1093/milmed/usaf647","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Military personnel encounter a wide range of environmental and occupational exposures during their service such as burn pit smoke, chemical warfare agents, depleted uranium, jet fuel, radiation, and pesticides. The field of military exposures research seeks to better understand the nature of these exposures and their effects on Veteran and service member health. This state-of-the-art review assesses the breadth and depth of published military exposures research so that stakeholders can identify trends and gaps in this growing field.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;An evidence mapping approach was used to perform a literature review of military exposures research published from 1962 to 2024. The search strategy was developed around exposed cohorts: groups of military personnel with a shared potential for exposure to toxic agents. Publications were included if they directly addressed exposures or related health outcomes in military cohorts. Publications were then further categorized by the type of research, and the results were analyzed to build a map of the current military exposures research landscape.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Thirty-six exposed cohorts were identified in the literature which were then grouped based on the nature of the exposure event: Wars and Operations (4 cohorts), Occupational Exposures (5), Combat and Combat Training (2), Across Military (2), Ship Exposures (2), Defense Testing (2), Base/Garrison Exposures (9), Toxic Substance Clean-Up and Disposal (5), and Isolated Exposure Events (5). The search identified 2,321 publications that fit the review inclusion criteria. The exposed cohort with the highest number of publications was Gulf War (940, 40.5% of all publications) followed by Vietnam War (277, 11.9%), Post-9/11 Operations in Iraq and Afghanistan (191, 8.2%), Aircraft Mechanics and Ground Support (176, 7.6%), and Munition Emissions and Embedded Fragments (164, 7.1%). Each remaining cohort individually represented &lt; 4% of the literature. Six cohorts appeared only in non-peer-reviewed reports. The type of research best represented was Epidemiology (34.0%) followed by Animal and In Vitro Models (18.8%), Sequelae and Management (17.1%), Reviews and Meta-Analyses (11.7%), Exposure Assessment (9.5%), Toxic Agent Sampling and Analysis (4.3%), and publications from the National Academy of Sciences, Engineering, and Medicine (4.6%). The volume of military exposures research has increased steadily since the early public reports of Gulf War Illness in 1994, with 50% of articles being published after 2008.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Military exposures research published since 1962 has focused on cohorts from large, high-profile deployments, particularly the Gulf War. Underrepresented cohorts with potential exposures on bases or from military occupations present opportunities for future research. The lack of meaningful exposure assessment data that has been published also","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of Vestibular Performance in Pilot and Non-Pilot Service Members in Naval Aviation. 海军航空兵飞行员与非飞行员前庭功能的比较研究。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-31 DOI: 10.1093/milmed/usaf604
Julia A Lytle, Andrew J Kittelson, Tyler Cardinale, Trevor Kingsbury, Eric Infante, Joshua D Winters, Brian J Loyd
<p><strong>Introduction: </strong>The vestibular system plays a critical role in maintaining gaze stability during head movement, a function largely controlled by the vestibulo-ocular reflex (VOR). When the VOR is impaired, individuals may experience blurred vision, dizziness, and other symptoms that interfere with daily activities. Dynamic visual acuity (DVA), or the ability to clearly identify a visual target during head movement, provides a functional measure of VOR performance and can be assessed using computerized tools. Military aviators are frequently exposed to situations that place high demands on the vestibular system. This study aims to evaluate DVA among rotary wing Naval aviators, hypothesizing that pilots would demonstrate superior DVA relative to non-pilot personnel. A secondary aim was to explore the relationship between flight hours and DVA performance in pilots, along with evaluation of other demographics.</p><p><strong>Materials and methods: </strong>This study included 96 participants, 58 rotary wing pilots and 38 non-pilot maintenance crew members, from Naval Air Station North Island and Marine Corps Air Station (MCAS) Miramar. All participants were active duty service members who voluntarily completed a DVA assessment under the Naval Medical Center San Diego IRB protocol NMCSD.2021.005 as a part of a larger clinical human performance program. Participation was open regardless of age or sex, and recruitment occurred through word of mouth via squadron leadership and Naval Medical Center San Diego (NMCSD) briefs. Dynamic visual acuity was assessed using a computerized test validated in previous NIH Toolbox studies. This required static head movements and horizontal head movements that exceeded 180 deg/sec while identifying briefly presented optotypes. Independent t-tests and chi-square tests were used to compare demographics and visual acuity between groups. A linear model controlled for age and static acuity when comparing DVA scores. Among pilots, Pearson correlation assessed the relationship between flight hours and DVA.</p><p><strong>Results: </strong>There were no significant differences in demographics or static visual acuity between pilots and non-pilots. Pilots demonstrated significantly better DVA (0.15 ± 0.08 LogMAR) than non-pilots (0.22 ± 0.22 LogMAR), even when adjusted for age and static acuity (P = .01). Static acuity was strongly related to DVA (Beta = 0.65, P < .0001), whereas age was not. Among pilots, flight hours (mean = 916 ± 748 hours) were not correlated with DVA performance.</p><p><strong>Conclusions: </strong>This study found that rotary wing Naval aviators exhibit superior DVA compared to non-pilots. These findings highlight potential vestibulo-ocular adaptations potentially from the constant occupational demands of aviation or because of the competitive selection process Naval aviators face. Although no correlation was found between flight hours and DVA, further longitudinal studies are needed to clar
前庭系统在维持头部运动时的凝视稳定性方面起着关键作用,这一功能主要由前庭-眼反射(VOR)控制。当VOR受损时,个人可能会出现视力模糊、头晕和其他干扰日常活动的症状。动态视敏度(DVA),或在头部运动中清晰识别视觉目标的能力,提供了VOR性能的功能测量,可以使用计算机化工具进行评估。军事飞行员经常暴露在对前庭系统有高要求的情况下。本研究旨在评估海军旋翼飞行员的DVA,并假设飞行员的DVA优于非飞行员。第二个目的是探索飞行时数与飞行员DVA表现之间的关系,以及对其他人口统计数据的评估。材料与方法:本研究包括来自北岛海军航空站和米拉马尔海军陆战队航空站(MCAS)的96名参与者,58名旋翼飞行员和38名非飞行员维修人员。所有参与者均为现役军人,根据圣地亚哥海军医疗中心IRB方案NMCSD.2021.005自愿完成了DVA评估,作为更大的临床人类表现项目的一部分。无论年龄或性别,都可以参加,招募是通过中队领导和圣地亚哥海军医疗中心(NMCSD)简报口耳相传进行的。动态视力评估使用计算机测试验证了以前的NIH工具箱研究。这需要静态头部运动和水平头部运动超过180度/秒,同时识别简要呈现的光型。采用独立t检验和卡方检验比较组间人口统计学特征和视敏度。在比较DVA分数时,控制年龄和静态敏锐度的线性模型。在飞行员中,Pearson相关评估飞行时数与DVA之间的关系。结果:飞行员和非飞行员在人口统计学和静态视敏度方面无显著差异。飞行员的DVA(0.15±0.08 LogMAR)明显优于非飞行员(0.22±0.22 LogMAR),即使在调整年龄和静态视力后也是如此(P = 0.01)。静态视敏度与DVA显著相关(Beta = 0.65, P)。结论:海军旋翼飞行员的DVA优于非飞行员。这些发现强调了潜在的前庭-眼适应可能来自航空的持续职业需求或海军飞行员面临的竞争性选拔过程。虽然没有发现飞行时间与DVA之间的相关性,但需要进一步的纵向研究来阐明DVA是否随时间或暴露而变化。这项研究是基准测试的第一步,并试图量化飞行员和非飞行员在DVA方面的差异。展望未来,DVA可以在了解飞行员前庭系统的健康方面发挥至关重要的作用,同时也可以最大限度地提高他们在飞机上的性能和安全性。未来的研究应该着眼于追踪DVA在飞行员职业生涯或前庭损伤后的变化,同时也扩展到其他航空界。
{"title":"A Comparative Study of Vestibular Performance in Pilot and Non-Pilot Service Members in Naval Aviation.","authors":"Julia A Lytle, Andrew J Kittelson, Tyler Cardinale, Trevor Kingsbury, Eric Infante, Joshua D Winters, Brian J Loyd","doi":"10.1093/milmed/usaf604","DOIUrl":"https://doi.org/10.1093/milmed/usaf604","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The vestibular system plays a critical role in maintaining gaze stability during head movement, a function largely controlled by the vestibulo-ocular reflex (VOR). When the VOR is impaired, individuals may experience blurred vision, dizziness, and other symptoms that interfere with daily activities. Dynamic visual acuity (DVA), or the ability to clearly identify a visual target during head movement, provides a functional measure of VOR performance and can be assessed using computerized tools. Military aviators are frequently exposed to situations that place high demands on the vestibular system. This study aims to evaluate DVA among rotary wing Naval aviators, hypothesizing that pilots would demonstrate superior DVA relative to non-pilot personnel. A secondary aim was to explore the relationship between flight hours and DVA performance in pilots, along with evaluation of other demographics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;This study included 96 participants, 58 rotary wing pilots and 38 non-pilot maintenance crew members, from Naval Air Station North Island and Marine Corps Air Station (MCAS) Miramar. All participants were active duty service members who voluntarily completed a DVA assessment under the Naval Medical Center San Diego IRB protocol NMCSD.2021.005 as a part of a larger clinical human performance program. Participation was open regardless of age or sex, and recruitment occurred through word of mouth via squadron leadership and Naval Medical Center San Diego (NMCSD) briefs. Dynamic visual acuity was assessed using a computerized test validated in previous NIH Toolbox studies. This required static head movements and horizontal head movements that exceeded 180 deg/sec while identifying briefly presented optotypes. Independent t-tests and chi-square tests were used to compare demographics and visual acuity between groups. A linear model controlled for age and static acuity when comparing DVA scores. Among pilots, Pearson correlation assessed the relationship between flight hours and DVA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There were no significant differences in demographics or static visual acuity between pilots and non-pilots. Pilots demonstrated significantly better DVA (0.15 ± 0.08 LogMAR) than non-pilots (0.22 ± 0.22 LogMAR), even when adjusted for age and static acuity (P = .01). Static acuity was strongly related to DVA (Beta = 0.65, P &lt; .0001), whereas age was not. Among pilots, flight hours (mean = 916 ± 748 hours) were not correlated with DVA performance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study found that rotary wing Naval aviators exhibit superior DVA compared to non-pilots. These findings highlight potential vestibulo-ocular adaptations potentially from the constant occupational demands of aviation or because of the competitive selection process Naval aviators face. Although no correlation was found between flight hours and DVA, further longitudinal studies are needed to clar","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lessons Learned From a Nationwide Implementation of Airborne Hazards and Open Burn Pits Registry Clinical Examinations: A Qualitative Assessment. 从全国实施空气传播危害和露天烧伤坑登记临床检查的经验教训:定性评估。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-31 DOI: 10.1093/milmed/usaf651
Trenton M Haltom, Timothy Zhou, Lindsay Vaclavik, Kayla Grimes, Israel C Christie, Kyler M Godwin, Drew A Helmer

Introduction: The Airborne Hazards and Open Burn Pits Registry (AHOBPR) examination was a service for Veterans with concerns about environmental exposures during military deployments. Interested Veterans enrolled in the AHOBPR online, completed a questionnaire, and indicated interest in a clinical examination by a Veterans Health Administration clinician. Several factors (e.g., COVID, unanticipated demand, and personnel turnover) resulted in a large number of pending examinations nationwide by 2022, prompting an evaluation and implementation effort to accelerate completion of high-quality examinations.Our objective was to assess Veterans' and clinical team members' perspectives of AHOBPR examinations to improve their delivery.

Meterials and methods: Qualitative interviews with Veterans who had completed an AHOBPR examination and clinical team members (CTMs) at 2 Veterans Affairs (VA) sites participating in our implementation. We recruited Veterans within 6 months of completing their examination and home facility complexity and performance metrics. We recruited CTMs for interviews from 2 purposefully selected VA facilities that completed all assessments conducted by our implementation team. Interviews were conducted between September 2022 and January 2023. We analyzed transcripts using rapid analysis. We apply the Promoting Action on Research Implementation in Health Service (PARiHS) framework to inform our interpretation of findings.

Results: Twenty-one Veterans and 9 CTMs from 2 sites completed interviews. Themes identified in the interviews were consistent with the PARiHS elements of evidence, context, and facilitation. Both Veterans and CTMs wanted evidence of appropriate knowledge about the AHOBPR and deployment and understanding AHOBPR structures and facility processes, including appropriate documentation of Veteran concerns. Contextually, Veterans and CTMs shared their strategies or experiences in clinical interactions especially the focus on developing patient-provider rapport and being prepared for examinations. Examples of facilitation included both groups' personal and professional motivations for conducting or pursuing examinations. Facilitation also involved local administrators and leaders providing the necessary staff, support, and resources.

Conclusions: Assessing Veteran and clinical team member (CTM) perceptions of AHOBPR examinations revealed clinically relevant opportunities important to addressing military and environmental exposure concerns of veterans (i.e., "exposure-informed care"). Clinical leaders can use the PARiHS framework and lessons learned from the AHOBPR experience to assess implementation and improve delivery of other novel services.

简介:机载危害和露天烧伤坑登记(AHOBPR)考试是为退伍军人提供的一项服务,他们关注军事部署期间的环境暴露。感兴趣的退伍军人在网上注册了AHOBPR,完成了一份调查问卷,并表示对退伍军人健康管理局临床医生的临床检查感兴趣。受新冠肺炎疫情、意外需求和人员流失等因素影响,到2022年全国将有大量考试待决,因此需要开展评估和实施工作,以加快完成高质量考试。我们的目的是评估退伍军人和临床团队成员对AHOBPR检查的看法,以改善他们的交付。材料和方法:对参与实施的2个退伍军人事务部(VA)的完成了AHOBPR检查的退伍军人和临床团队成员(CTMs)进行定性访谈。我们在6个月内招募退伍军人完成他们的检查和家庭设施的复杂性和性能指标。我们从两个有目的地选择的VA设施中招募了CTMs进行访谈,这些设施完成了我们实施团队进行的所有评估。采访在2022年9月至2023年1月期间进行。我们使用快速分析来分析转录本。我们应用卫生服务研究实施促进行动(parhis)框架来解释我们的研究结果。结果:21名退伍军人和9名中医完成了访谈。访谈中确定的主题与parhis的证据、背景和促进要素一致。退伍军人和ctm都需要关于AHOBPR和部署的适当知识的证据,以及对AHOBPR结构和设施流程的理解,包括退伍军人关注的适当文件。在此背景下,退伍军人和中医医生分享了他们在临床互动方面的策略或经验,特别是在发展医患关系和为检查做准备方面。促进的例子包括两组进行或参加考试的个人和专业动机。促进工作还涉及地方行政人员和领导人提供必要的人员、支持和资源。结论:评估退伍军人和临床团队成员(CTM)对AHOBPR检查的看法,揭示了解决退伍军人军事和环境暴露问题(即“暴露知情护理”)的临床相关机会。临床领导者可以使用PARiHS框架和从abhobpr经验中吸取的教训来评估实施和改进其他新服务的交付。
{"title":"Lessons Learned From a Nationwide Implementation of Airborne Hazards and Open Burn Pits Registry Clinical Examinations: A Qualitative Assessment.","authors":"Trenton M Haltom, Timothy Zhou, Lindsay Vaclavik, Kayla Grimes, Israel C Christie, Kyler M Godwin, Drew A Helmer","doi":"10.1093/milmed/usaf651","DOIUrl":"https://doi.org/10.1093/milmed/usaf651","url":null,"abstract":"<p><strong>Introduction: </strong>The Airborne Hazards and Open Burn Pits Registry (AHOBPR) examination was a service for Veterans with concerns about environmental exposures during military deployments. Interested Veterans enrolled in the AHOBPR online, completed a questionnaire, and indicated interest in a clinical examination by a Veterans Health Administration clinician. Several factors (e.g., COVID, unanticipated demand, and personnel turnover) resulted in a large number of pending examinations nationwide by 2022, prompting an evaluation and implementation effort to accelerate completion of high-quality examinations.Our objective was to assess Veterans' and clinical team members' perspectives of AHOBPR examinations to improve their delivery.</p><p><strong>Meterials and methods: </strong>Qualitative interviews with Veterans who had completed an AHOBPR examination and clinical team members (CTMs) at 2 Veterans Affairs (VA) sites participating in our implementation. We recruited Veterans within 6 months of completing their examination and home facility complexity and performance metrics. We recruited CTMs for interviews from 2 purposefully selected VA facilities that completed all assessments conducted by our implementation team. Interviews were conducted between September 2022 and January 2023. We analyzed transcripts using rapid analysis. We apply the Promoting Action on Research Implementation in Health Service (PARiHS) framework to inform our interpretation of findings.</p><p><strong>Results: </strong>Twenty-one Veterans and 9 CTMs from 2 sites completed interviews. Themes identified in the interviews were consistent with the PARiHS elements of evidence, context, and facilitation. Both Veterans and CTMs wanted evidence of appropriate knowledge about the AHOBPR and deployment and understanding AHOBPR structures and facility processes, including appropriate documentation of Veteran concerns. Contextually, Veterans and CTMs shared their strategies or experiences in clinical interactions especially the focus on developing patient-provider rapport and being prepared for examinations. Examples of facilitation included both groups' personal and professional motivations for conducting or pursuing examinations. Facilitation also involved local administrators and leaders providing the necessary staff, support, and resources.</p><p><strong>Conclusions: </strong>Assessing Veteran and clinical team member (CTM) perceptions of AHOBPR examinations revealed clinically relevant opportunities important to addressing military and environmental exposure concerns of veterans (i.e., \"exposure-informed care\"). Clinical leaders can use the PARiHS framework and lessons learned from the AHOBPR experience to assess implementation and improve delivery of other novel services.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initial Evaluation and Implementation of Simulation-based Death Notification Training for Military Residents. 基于模拟的军人住院医师死亡通报训练的初步评估与实施。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-30 DOI: 10.1093/milmed/usaf649
Marion Legay, Guillaume Vanderperre, Anaelle Leroux, Emilie Roméo, Matthieu Patient, Christophe Dubecq, Jean Sébastien Bladé, Henri de Lesquen, Laurys Boudin

Introduction: Notifying a patient's family that the patient has died is a delicate and sensitive task in medical practice. This is particularly true in the military population due to the frequent unexpected and sudden nature of death. Medical students in France receive no systematic training in death notification, either in civilian or military settings. Therefore, the researchers sought to (1) assess the initial level of training of military medical residents in announcing death, (2) design an adapted simulation-based training program after the observation of possible gaps, (3) evaluate its impact on their perceived self-efficacy, and (4) assess the program's long-term relevance.

Materials and methods: The researchers conducted an observational study followed by a simulation-based educational intervention. First, a questionnaire was distributed to two cohorts of military medical residents, who began their residency in 2023 and 2024. The questionnaire assessed their training level, experience, and perceptions regarding death announcement. Based on the findings, a tailored theoretical and practical simulation-based training was developed and delivered. Pre- and post-training self-assessment questionnaires and a 5-month follow-up survey were used to evaluate the impact and retention of learning outcomes.

Results: A total of 72 residents (45%) completed the initial questionnaire. The mean age of the participants was 25 ± 1.5 years, and 61% of the respondents were female. Most participants (57/72, 79%) specialized in general practice. Only 19% (14/72) had previously announced a death, and 44% (32/72) declared that they had received some form of related training during their curriculum, which was simulation-based for 35% (25/72). Of the 14 residents who had to announce a death, 9 (65%) felt little or not at all prepared. Overall, 40 residents participated in the simulation-based training, which led to a statistically significant improvement (P < .05) in eight out of 10 assessed skills. At 5-month follow-up, all residents who had to deliver a death notification reported the training as useful.

Conclusions: The initial assessment revealed a clear need for specialized training in announcing death for future military physicians. The implemented simulation-based program significantly enhanced the residents' sense of self-efficacy. There is strong support for integrating the program into the curriculum annually, as it appears to effectively improve the quality of care provided to grieving families.

在医疗实践中,通知病人家属病人已经死亡是一项微妙而敏感的任务。这在军人群体中尤其如此,因为死亡往往是意外和突然的。法国的医科学生没有接受过关于死亡通知的系统培训,无论是在民用还是军事环境中。因此,研究者试图(1)评估军队住院医师宣布死亡的初始训练水平,(2)在观察可能的差距后设计一个适应性的基于模拟的训练计划,(3)评估其对他们感知自我效能的影响,以及(4)评估计划的长期相关性。材料和方法:研究人员进行了一项观察性研究,随后进行了基于模拟的教育干预。首先,对两组分别于2023年和2024年开始住院的军事医疗住院医师发放调查问卷。调查问卷评估了他们的培训水平、经验和对死亡宣布的看法。根据研究结果,开发并提供了量身定制的理论和实践模拟培训。采用培训前后自我评估问卷和5个月的随访调查来评估学习成果的影响和保留。结果:共有72名居民(45%)完成了初始问卷。参与者的平均年龄为25±1.5岁,61%的受访者为女性。大多数参与者(57/72,79%)是全科医生。只有19%(14/72)的学生以前宣布过死亡,44%(32/72)的学生声称他们在课程中接受过某种形式的相关培训,其中35%(25/72)的学生接受过基于模拟的培训。在14名不得不宣布死亡的居民中,9名(65%)感到很少或根本没有准备。总的来说,有40名住院医生参加了模拟训练,这导致了统计学上显著的改善(P结论:初步评估表明,明确需要对未来的军医进行宣布死亡的专门培训。实施模拟方案后,居民的自我效能感显著增强。人们强烈支持将该项目纳入每年的课程,因为它似乎有效地提高了为悲伤家庭提供的护理质量。
{"title":"Initial Evaluation and Implementation of Simulation-based Death Notification Training for Military Residents.","authors":"Marion Legay, Guillaume Vanderperre, Anaelle Leroux, Emilie Roméo, Matthieu Patient, Christophe Dubecq, Jean Sébastien Bladé, Henri de Lesquen, Laurys Boudin","doi":"10.1093/milmed/usaf649","DOIUrl":"https://doi.org/10.1093/milmed/usaf649","url":null,"abstract":"<p><strong>Introduction: </strong>Notifying a patient's family that the patient has died is a delicate and sensitive task in medical practice. This is particularly true in the military population due to the frequent unexpected and sudden nature of death. Medical students in France receive no systematic training in death notification, either in civilian or military settings. Therefore, the researchers sought to (1) assess the initial level of training of military medical residents in announcing death, (2) design an adapted simulation-based training program after the observation of possible gaps, (3) evaluate its impact on their perceived self-efficacy, and (4) assess the program's long-term relevance.</p><p><strong>Materials and methods: </strong>The researchers conducted an observational study followed by a simulation-based educational intervention. First, a questionnaire was distributed to two cohorts of military medical residents, who began their residency in 2023 and 2024. The questionnaire assessed their training level, experience, and perceptions regarding death announcement. Based on the findings, a tailored theoretical and practical simulation-based training was developed and delivered. Pre- and post-training self-assessment questionnaires and a 5-month follow-up survey were used to evaluate the impact and retention of learning outcomes.</p><p><strong>Results: </strong>A total of 72 residents (45%) completed the initial questionnaire. The mean age of the participants was 25 ± 1.5 years, and 61% of the respondents were female. Most participants (57/72, 79%) specialized in general practice. Only 19% (14/72) had previously announced a death, and 44% (32/72) declared that they had received some form of related training during their curriculum, which was simulation-based for 35% (25/72). Of the 14 residents who had to announce a death, 9 (65%) felt little or not at all prepared. Overall, 40 residents participated in the simulation-based training, which led to a statistically significant improvement (P < .05) in eight out of 10 assessed skills. At 5-month follow-up, all residents who had to deliver a death notification reported the training as useful.</p><p><strong>Conclusions: </strong>The initial assessment revealed a clear need for specialized training in announcing death for future military physicians. The implemented simulation-based program significantly enhanced the residents' sense of self-efficacy. There is strong support for integrating the program into the curriculum annually, as it appears to effectively improve the quality of care provided to grieving families.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Scoping Review of Risk Factors of Postpartum Depression among Military Personnel and Spouses. 军人及其配偶产后抑郁危险因素的范围分析。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-30 DOI: 10.1093/milmed/usag005
Catherine Biegel, Hailee Poulin, Sophia Silvia, Geoffrey McCullen

Introduction: In recent years, there has been increased recognition and awareness surrounding mental health among US military personnel. However, the prevalence of postpartum depression (PPD) among female service members is significantly higher than that of the general US population. There is currently a gap in the literature characterizing the unique factors of the military experience accounting for the higher predisposition to PPD relative to civilian Americans. This qualitative review aims to address this gap by isolating risk factors which have been consistently identified in the available literature as contributing to the prevalence discrepancy.

Materials and methods: A MeSH database-built search utilizing key terms "postpartum depression" and "military" was used to gather sources that fit the inclusion criteria. These sources were analyzed for explicitly identified PPD risk factors pertaining to US military personnel and spouses.

Results: Of the 14 sources meeting inclusion criteria, a history of a mental health disorder and a lack of social support were identified in seven distinct articles as significant risk factors for PPD among military personnel. Low rank and pay, as well as deployments of self and/or spouse, were specified in six papers. A history of depression, history of anxiety, and exposure to combat were identified in five papers. Four papers isolated branch of service and young age as risk factors. Factors that were recognized in three papers or less included, but are not limited to: tobacco use, history of PTSD, history of sexual assault, low education attainment, high number of child dependents, race, and job stress.

Conclusions: Women in the military and spouses of military personnel are subject to an environment with distinct stressors, increasing their predisposition for PPD. Identifying specific risk factors is critical for quality screening, diagnosis, and care of PPD among this population. Significant risk factors consistently isolated from the available literature include history of mental health disorders, lack of adequate social support, low rank and pay, deployment of self or spouse, history of combat exposure, branch of service, and young maternal age. Findings of this review also suggest that early detection via thorough screening and disease mitigation by means of a 12-week maternity leave led to lower rates of PPD and better disease outcomes. Military-specific family health resources are widely available across branches of service and individual bases, though the use and quality of these resources are inconsistent. Providers of women experiencing at least one of these stressors should increase PPD precautions and refer patients to the appropriate preventative and acute care.

近年来,美国军人对心理健康的认识和认识有所提高。然而,女性服役人员产后抑郁症(PPD)的患病率明显高于美国总人口。目前,在描述军事经历的独特因素导致相对于平民美国人更高的PPD易感性方面,文献中存在空白。本定性综述旨在通过隔离现有文献中一致确定的导致患病率差异的风险因素来解决这一差距。材料和方法:利用关键词“产后抑郁”和“军事”建立MeSH数据库进行搜索,收集符合纳入标准的来源。对这些来源进行分析,明确确定与美国军事人员及其配偶有关的PPD风险因素。结果:在符合纳入标准的14个来源中,有7篇不同的文章确定了精神健康障碍史和缺乏社会支持是军人PPD的重要危险因素。六份文件详细说明了低级别和低薪酬,以及自己和/或配偶的部署。抑郁史、焦虑史和战斗经历在五篇论文中被确定。四篇论文分离了军种和年龄作为危险因素。在三篇或更少的论文中被确认的因素包括但不限于:吸烟、创伤后应激障碍史、性侵犯史、低教育程度、大量儿童依赖者、种族和工作压力。结论:军人及军人配偶所处的应激环境具有明显的应激源,增加了她们患PPD的易感性。确定特定的危险因素对于这一人群中PPD的高质量筛查、诊断和护理至关重要。从现有文献中一直孤立出来的重要风险因素包括精神病史、缺乏足够的社会支持、低军衔和工资、自己或配偶的部署、战斗暴露史、服务部门和年轻的母亲年龄。本综述的发现还表明,通过彻底筛查的早期发现和通过12周产假的方式缓解疾病,可以降低产后抑郁症的发病率和改善疾病结局。各军兵种和个别基地广泛提供针对军队的家庭保健资源,但这些资源的使用和质量参差不齐。经历至少一种压力源的妇女的提供者应该增加PPD预防措施,并将患者转介到适当的预防和急性护理。
{"title":"A Scoping Review of Risk Factors of Postpartum Depression among Military Personnel and Spouses.","authors":"Catherine Biegel, Hailee Poulin, Sophia Silvia, Geoffrey McCullen","doi":"10.1093/milmed/usag005","DOIUrl":"https://doi.org/10.1093/milmed/usag005","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, there has been increased recognition and awareness surrounding mental health among US military personnel. However, the prevalence of postpartum depression (PPD) among female service members is significantly higher than that of the general US population. There is currently a gap in the literature characterizing the unique factors of the military experience accounting for the higher predisposition to PPD relative to civilian Americans. This qualitative review aims to address this gap by isolating risk factors which have been consistently identified in the available literature as contributing to the prevalence discrepancy.</p><p><strong>Materials and methods: </strong>A MeSH database-built search utilizing key terms \"postpartum depression\" and \"military\" was used to gather sources that fit the inclusion criteria. These sources were analyzed for explicitly identified PPD risk factors pertaining to US military personnel and spouses.</p><p><strong>Results: </strong>Of the 14 sources meeting inclusion criteria, a history of a mental health disorder and a lack of social support were identified in seven distinct articles as significant risk factors for PPD among military personnel. Low rank and pay, as well as deployments of self and/or spouse, were specified in six papers. A history of depression, history of anxiety, and exposure to combat were identified in five papers. Four papers isolated branch of service and young age as risk factors. Factors that were recognized in three papers or less included, but are not limited to: tobacco use, history of PTSD, history of sexual assault, low education attainment, high number of child dependents, race, and job stress.</p><p><strong>Conclusions: </strong>Women in the military and spouses of military personnel are subject to an environment with distinct stressors, increasing their predisposition for PPD. Identifying specific risk factors is critical for quality screening, diagnosis, and care of PPD among this population. Significant risk factors consistently isolated from the available literature include history of mental health disorders, lack of adequate social support, low rank and pay, deployment of self or spouse, history of combat exposure, branch of service, and young maternal age. Findings of this review also suggest that early detection via thorough screening and disease mitigation by means of a 12-week maternity leave led to lower rates of PPD and better disease outcomes. Military-specific family health resources are widely available across branches of service and individual bases, though the use and quality of these resources are inconsistent. Providers of women experiencing at least one of these stressors should increase PPD precautions and refer patients to the appropriate preventative and acute care.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Major Adverse Coronary Events Status Post Percutaneous Coronary Intervention in Veterans Exposed to Agent Orange Versus Non-Exposed. 暴露于橙剂与未暴露于橙剂的退伍军人经皮冠状动脉介入治疗后的主要不良冠状动脉事件状况。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-28 DOI: 10.1093/milmed/usaf627
Sarah Neveills, Marguerite Engler, Catherine Battaglia, Laura Kaizer, Madhura Gokhale, Robert Leonard
<p><strong>Introduction: </strong>United States Veterans who served in Vietnam, the Korean Demilitarized Zone, or Thailand Air Force bases from 1962 to 1971 were likely exposed to Agent Orange, as approximately 107 million pounds of the chemical were sprayed in the areas where the fighting occurred. Agent Orange was an herbicide used by the United States military to kill the jungle, foliage, tall grasses, bushes, and weeds. Agent Orange contained 2,3,7,8-tetrachlorodibenzo-p-dioxin, the most toxic form of dioxin, which has been associated with multiple disease processes and cardiac issues.</p><p><strong>Materials and methods: </strong>An original quantitative descriptive, retrospective cohort, secondary data analysis study was conducted utilizing data collected by the Veterans Health Administration (VHA) via the Cardiovascular Assessment, Reporting, and Tracking System for Cath Labs and the Computerized Patient Record System. A new and innovative Structured Query Language report was created for data mining. Statistical tests included Chi-square tests, two-sample t-tests, prevalence, logistic regression, and odds ratios. A secondary analysis was conducted to assess for confounders, associations, and differences.</p><p><strong>Results: </strong>Veterans exposed to Agent Orange status post (s/p) percutaneous coronary intervention (PCI) have significantly higher body mass index (P ≤ .01), with a higher percentage of obesity (45.4% vs. 41.0%) and severe obesity (7.0% vs. 6.1%). There is a higher prevalence of those exposed to Agent Orange in the white (85% vs. 79.3%, P ≤ .01) and non-Hispanic/Latino (93.9% vs. 92.9%, P ≤ .01) male population. There is a higher prevalence of hypertension (91.3% vs. 90.7%, P = .03), hyperlipidemia (91.7% vs. 90.1%, P ≤ .01), and diabetes (53.5% vs. 49.8%, P ≤ .01) in those exposed vs. non-exposed. Lastly, there is a higher prevalence (1.8% vs. 1.5%) and fully adjusted odds 1.22 (95%CI: 1.08, 1.37; P = .0011) of coronary artery bypass graft surgery (CABG).</p><p><strong>Conclusions: </strong>Veterans exposed to Agent Orange are high-risk cardiovascular patients with a higher prevalence and odds of CABG s/p PCI. The increased prevalence of hypertension, hyperlipidemia, obesity, severe obesity, and diabetes in Veterans exposed to Agent Orange s/p PCI suggests that Agent Orange may contribute to the development of these disease processes. Strengths include the quality and longevity of the data collected, the Promise to Address Comprehensive Toxics (PACT) Act supporting Agent Orange research, and the advanced age of the Veterans increases the likelihood of cardiovascular disease. Weaknesses include the inability to quantify and confirm Agent Orange exposure, the inability to determine causation, and the VHA registrar's office could have erroneously assigned the Agent Orange disability flag by not verifying the service location. This study impacts the care of the Veterans s/p PCI; providers should assess the comorbidities, co
简介:1962年至1971年间在越南、朝鲜非军事区或泰国空军基地服役的美国退伍军人可能接触过橙剂,大约1.07亿磅的化学物质被喷洒在战斗发生的地区。橙剂是美国军方使用的一种除草剂,用来杀死丛林、树叶、高草、灌木和杂草。橙剂含有2,3,7,8-四氯二苯并-对二恶英,这是二恶英中毒性最大的一种,与多种疾病进程和心脏问题有关。材料和方法:一项原始的定量描述性、回顾性队列、二次数据分析研究利用退伍军人健康管理局(VHA)通过导管实验室心血管评估、报告和跟踪系统和计算机化患者记录系统收集的数据进行。为数据挖掘创建了一个新的、创新的结构化查询语言报告。统计检验包括卡方检验、双样本t检验、患病率、logistic回归和优势比。进行二次分析以评估混杂因素、关联和差异。结果:暴露于橙剂的退伍军人经皮冠状动脉介入治疗(PCI)后状态(s/p)体重指数(p≤。01),肥胖比例(45.4%比41.0%)和重度肥胖比例(7.0%比6.1%)更高。接触过橙剂的白人患病率较高(85% vs. 79.3%, P≤。01)和非西班牙裔/拉丁裔(93.9% vs. 92.9%, P≤。01)男性人口。高血压患病率较高(91.3% vs. 90.7%, P =。03)、高脂血症(91.7% vs. 90.1%, P≤。01),糖尿病(53.5% vs 49.8%, P≤。01)。最后,有更高的患病率(1.8%比1.5%)和完全调整的优势1.22 (95%CI: 1.08, 1.37; P =。0011)冠状动脉搭桥手术(CABG)。结论:暴露于橙剂的退伍军人是高危心血管患者,CABG /p PCI的患病率和几率较高。暴露于橙剂s/p PCI的退伍军人中高血压、高脂血症、肥胖、严重肥胖和糖尿病患病率的增加表明橙剂可能有助于这些疾病的发展。其优势包括所收集数据的质量和寿命,《解决全面有毒物质承诺法案》(PACT)支持橙剂研究,以及退伍军人的高龄增加了患心血管疾病的可能性。缺点包括无法量化和确认橙剂暴露,无法确定因果关系,并且VHA注册办公室可能由于未验证服务位置而错误地分配了橙剂残疾标志。本研究对退伍军人s/p PCI护理的影响;提供者应评估合并症、冠状动脉疾病进展、受影响的血管数量、心脏血管扭曲程度、冠状动脉病变位置、病变大小和所需支架数量,以确定重复PCI是否优于CABG治疗。未来的研究应包括PACT法案筛查中暴露于橙剂的新分类退伍军人,CABG结果,冠状动脉病变特征,支架类型以及最初PCI时处方的药物。
{"title":"Major Adverse Coronary Events Status Post Percutaneous Coronary Intervention in Veterans Exposed to Agent Orange Versus Non-Exposed.","authors":"Sarah Neveills, Marguerite Engler, Catherine Battaglia, Laura Kaizer, Madhura Gokhale, Robert Leonard","doi":"10.1093/milmed/usaf627","DOIUrl":"https://doi.org/10.1093/milmed/usaf627","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;United States Veterans who served in Vietnam, the Korean Demilitarized Zone, or Thailand Air Force bases from 1962 to 1971 were likely exposed to Agent Orange, as approximately 107 million pounds of the chemical were sprayed in the areas where the fighting occurred. Agent Orange was an herbicide used by the United States military to kill the jungle, foliage, tall grasses, bushes, and weeds. Agent Orange contained 2,3,7,8-tetrachlorodibenzo-p-dioxin, the most toxic form of dioxin, which has been associated with multiple disease processes and cardiac issues.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;An original quantitative descriptive, retrospective cohort, secondary data analysis study was conducted utilizing data collected by the Veterans Health Administration (VHA) via the Cardiovascular Assessment, Reporting, and Tracking System for Cath Labs and the Computerized Patient Record System. A new and innovative Structured Query Language report was created for data mining. Statistical tests included Chi-square tests, two-sample t-tests, prevalence, logistic regression, and odds ratios. A secondary analysis was conducted to assess for confounders, associations, and differences.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Veterans exposed to Agent Orange status post (s/p) percutaneous coronary intervention (PCI) have significantly higher body mass index (P ≤ .01), with a higher percentage of obesity (45.4% vs. 41.0%) and severe obesity (7.0% vs. 6.1%). There is a higher prevalence of those exposed to Agent Orange in the white (85% vs. 79.3%, P ≤ .01) and non-Hispanic/Latino (93.9% vs. 92.9%, P ≤ .01) male population. There is a higher prevalence of hypertension (91.3% vs. 90.7%, P = .03), hyperlipidemia (91.7% vs. 90.1%, P ≤ .01), and diabetes (53.5% vs. 49.8%, P ≤ .01) in those exposed vs. non-exposed. Lastly, there is a higher prevalence (1.8% vs. 1.5%) and fully adjusted odds 1.22 (95%CI: 1.08, 1.37; P = .0011) of coronary artery bypass graft surgery (CABG).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Veterans exposed to Agent Orange are high-risk cardiovascular patients with a higher prevalence and odds of CABG s/p PCI. The increased prevalence of hypertension, hyperlipidemia, obesity, severe obesity, and diabetes in Veterans exposed to Agent Orange s/p PCI suggests that Agent Orange may contribute to the development of these disease processes. Strengths include the quality and longevity of the data collected, the Promise to Address Comprehensive Toxics (PACT) Act supporting Agent Orange research, and the advanced age of the Veterans increases the likelihood of cardiovascular disease. Weaknesses include the inability to quantify and confirm Agent Orange exposure, the inability to determine causation, and the VHA registrar's office could have erroneously assigned the Agent Orange disability flag by not verifying the service location. This study impacts the care of the Veterans s/p PCI; providers should assess the comorbidities, co","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-Anticoagulated Fresh Whole Blood Syringe Transfusion as an Alternative for Military Hemorrhage Resuscitation in Austere Environments. 非抗凝新鲜全血注射器输注作为严峻环境下军事出血复苏的替代方法。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-27 DOI: 10.1093/milmed/usaf564
Christopher J Scheiber, Sarah Glier, Justin Magin, Mark Hanlon, Matthew Vander Ploeg, Bryan Obika, Herman Freeman, Om Dave, Andrew Tolksdorf, Richard D Neading, Alexander Doyal, Alan Smeltz

Introduction: Military field medicine providers often operate in resource-limited environments where improvization with available equipment is essential. Whole blood transfusion has had significant benefits in treating severely injured trauma patients in these settings. Current protocols often mandate anticoagulant-containing intravenous (IV) fluid bags for fresh whole blood transfusion, which can pose logistical challenges for forward-placed medical units. This study explores the feasibility of using a syringe without anticoagulant as an alternative method.

Materials and methods: Whole blood was collected from healthy volunteer donors and divided into syringes with and without citrate-phosphate-dextrose (CPD) solution. Samples were stored for varying durations and infused through a standard IV setup to simulate transfusion conditions. To assess coagulation, infusion rate under standardized infusion pressure, clot mass, and coagulation parameters (PT/INR, PTT) was measured. Hemolysis was assessed by measuring plasma hemoglobin, potassium, lactate dehydrogenase (LDH), bilirubin pre- and post-infusion at either 100 mL/minute, 200 mL/minute or maximal manual compression.

Results: We performed a nested analysis of variance (ANOVA) analysis on coagulation and hemolysis parameters. Tukey post-hoc testing was used to determine mean subgroup differences. Analyses were carried out using R version 4.3.0 (R Core Team, 2024). Significant differences were observed in infusion rates across different storage times but not between CPD and non-CPD conditions. There was significantly greater clot burden in non-CPD groups compared to CPD at 30 minutes (6.5 ± 2.1 g) and 60 minutes (8.8 ± 1.9 g), but no significant difference was observed in the 30 second (0.001 ± 2.0 g) and 5 minute (1.1 ± 2.0 g) groups. Coagulation parameters (INR, PT, and PTT) showed no significant differences based on storage time but were impacted by the presence of CPD. Hemolysis markers indicated significant changes in plasma hemoglobin with higher infusion rates but no significant alterations in LDH, potassium, or bilirubin at any of the infusion rates.

Conclusions: These findings suggest that non-anticoagulated fresh whole blood may be transfused within 5 minutes at infusion rates of 100 mL/minute or less with no significant clot burden and no evidence of hemolysis. Longer storage times and faster infusion rates may also be clinical safe but require further investigation. This study indicates that there may be some potential use of this method in military units executing a fresh whole blood draw with short donor-to-recipient times.

简介:军事野战医疗提供者经常在资源有限的环境中工作,在这种环境中,利用现有设备进行改进是必不可少的。在这些情况下,全血输血在治疗严重创伤患者方面具有显著的益处。目前的方案通常要求在新鲜全血输注时使用含有抗凝剂的静脉输液袋,这可能给前沿医疗单位带来后勤挑战。本研究探讨了使用无抗凝剂注射器作为替代方法的可行性。材料与方法:采集健康志愿献血者全血,分为含和不含柠檬酸-磷酸盐-葡萄糖(CPD)溶液的注射器。样品保存不同的时间,并通过标准的静脉注射装置来模拟输血条件。为了评估凝血,测量了标准化输注压力下的输注速率、凝块质量和凝血参数(PT/INR, PTT)。通过测定血浆血红蛋白、钾、乳酸脱氢酶(LDH)、胆红素在100ml /分钟、200ml /分钟或最大手动按压下输注前后的溶血情况来评估。结果:我们对凝血和溶血参数进行了嵌套方差分析(ANOVA)。采用Tukey事后检验来确定平均亚组差异。使用R 4.3.0版本(R Core Team, 2024)进行分析。在不同的储存时间内观察到输液速率的显著差异,但在CPD和非CPD条件下没有显著差异。与CPD组相比,非CPD组在30分钟(6.5±2.1 g)和60分钟(8.8±1.9 g)时的凝块负担显著增加,但在30秒(0.001±2.0 g)和5分钟(1.1±2.0 g)时无显著差异。凝血参数(INR、PT和PTT)在储存时间上无显著差异,但受到CPD存在的影响。溶血标志物显示血浆血红蛋白随输注速率升高而发生显著变化,但在任何输注速率下LDH、钾或胆红素均无显著变化。结论:这些研究结果表明,以100ml /分钟或更低的输注速率在5分钟内输注无抗凝血的新鲜全血,没有明显的凝块负担,没有溶血的证据。更长的储存时间和更快的输注速度也可能是临床安全的,但需要进一步的研究。本研究表明,这种方法可能在军事单位执行新鲜全血抽取,供者到接受者的时间较短。
{"title":"Non-Anticoagulated Fresh Whole Blood Syringe Transfusion as an Alternative for Military Hemorrhage Resuscitation in Austere Environments.","authors":"Christopher J Scheiber, Sarah Glier, Justin Magin, Mark Hanlon, Matthew Vander Ploeg, Bryan Obika, Herman Freeman, Om Dave, Andrew Tolksdorf, Richard D Neading, Alexander Doyal, Alan Smeltz","doi":"10.1093/milmed/usaf564","DOIUrl":"https://doi.org/10.1093/milmed/usaf564","url":null,"abstract":"<p><strong>Introduction: </strong>Military field medicine providers often operate in resource-limited environments where improvization with available equipment is essential. Whole blood transfusion has had significant benefits in treating severely injured trauma patients in these settings. Current protocols often mandate anticoagulant-containing intravenous (IV) fluid bags for fresh whole blood transfusion, which can pose logistical challenges for forward-placed medical units. This study explores the feasibility of using a syringe without anticoagulant as an alternative method.</p><p><strong>Materials and methods: </strong>Whole blood was collected from healthy volunteer donors and divided into syringes with and without citrate-phosphate-dextrose (CPD) solution. Samples were stored for varying durations and infused through a standard IV setup to simulate transfusion conditions. To assess coagulation, infusion rate under standardized infusion pressure, clot mass, and coagulation parameters (PT/INR, PTT) was measured. Hemolysis was assessed by measuring plasma hemoglobin, potassium, lactate dehydrogenase (LDH), bilirubin pre- and post-infusion at either 100 mL/minute, 200 mL/minute or maximal manual compression.</p><p><strong>Results: </strong>We performed a nested analysis of variance (ANOVA) analysis on coagulation and hemolysis parameters. Tukey post-hoc testing was used to determine mean subgroup differences. Analyses were carried out using R version 4.3.0 (R Core Team, 2024). Significant differences were observed in infusion rates across different storage times but not between CPD and non-CPD conditions. There was significantly greater clot burden in non-CPD groups compared to CPD at 30 minutes (6.5 ± 2.1 g) and 60 minutes (8.8 ± 1.9 g), but no significant difference was observed in the 30 second (0.001 ± 2.0 g) and 5 minute (1.1 ± 2.0 g) groups. Coagulation parameters (INR, PT, and PTT) showed no significant differences based on storage time but were impacted by the presence of CPD. Hemolysis markers indicated significant changes in plasma hemoglobin with higher infusion rates but no significant alterations in LDH, potassium, or bilirubin at any of the infusion rates.</p><p><strong>Conclusions: </strong>These findings suggest that non-anticoagulated fresh whole blood may be transfused within 5 minutes at infusion rates of 100 mL/minute or less with no significant clot burden and no evidence of hemolysis. Longer storage times and faster infusion rates may also be clinical safe but require further investigation. This study indicates that there may be some potential use of this method in military units executing a fresh whole blood draw with short donor-to-recipient times.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Military Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1