Dylan M Griffiths, Meg I Robinson, Amber L Dougherty, Laura S Kraemer, Andrew J Macgregor, James D Wallace, Diego A Vicente, Christian S Mcevoy
Introduction: Sacrococcygeal pilonidal disease (PD) is a common surgical problem in the U.S. Military. Despite recent advancements, treatment strategies remain heterogenous and incompletely described, particularly among the active duty component in the Military Health System (MHS). This study's objectives were to identify the burden of PD and describe current healthcare utilization and treatment patterns in the MHS during a recent 10-year study period.
Materials and methods: The study population included all active duty U.S. service members with at least one PD diagnosis in the MHS Data Repository between January 1, 2013, and December 31, 2022. For each patient, the first PD diagnosis during the study period was the incident case, and a subsequent case was defined as a second PD diagnosis >30 days after the first and categorized as recurrent (procedure performed at incident encounter) or persistent (no procedure performed at incident encounter). Procedures were identified by Current Procedural Terminology codes.
Results: During the study period, 25,039 active duty service members were diagnosed with an incident case of PD. The study population was mostly male, less than 30 years old, enlisted, and in the Army or Navy. The overall incidence rate was 1.7 per 1,000 person-years. Prevalence of recurrence was 44.6% (2,494 of 5,598) and persistence was 50.1% (9,731 of 19,441). Overall, there were 115,387 medical encounters with a PD diagnosis during the study period, and service members in the top 25% for healthcare utilization had ≥11 encounters with a PD diagnosis.
Conclusions: Pilonidal disease imposes a significant burden on the MHS and is a threat to overall force medical readiness. Treatment strategies remain heterogeneous, and prospective studies are needed to refine clinical guidelines.
{"title":"Pilonidal Disease: A Recent Decade of the Disease among Active Duty United States Military Service Members.","authors":"Dylan M Griffiths, Meg I Robinson, Amber L Dougherty, Laura S Kraemer, Andrew J Macgregor, James D Wallace, Diego A Vicente, Christian S Mcevoy","doi":"10.1093/milmed/usag015","DOIUrl":"https://doi.org/10.1093/milmed/usag015","url":null,"abstract":"<p><strong>Introduction: </strong>Sacrococcygeal pilonidal disease (PD) is a common surgical problem in the U.S. Military. Despite recent advancements, treatment strategies remain heterogenous and incompletely described, particularly among the active duty component in the Military Health System (MHS). This study's objectives were to identify the burden of PD and describe current healthcare utilization and treatment patterns in the MHS during a recent 10-year study period.</p><p><strong>Materials and methods: </strong>The study population included all active duty U.S. service members with at least one PD diagnosis in the MHS Data Repository between January 1, 2013, and December 31, 2022. For each patient, the first PD diagnosis during the study period was the incident case, and a subsequent case was defined as a second PD diagnosis >30 days after the first and categorized as recurrent (procedure performed at incident encounter) or persistent (no procedure performed at incident encounter). Procedures were identified by Current Procedural Terminology codes.</p><p><strong>Results: </strong>During the study period, 25,039 active duty service members were diagnosed with an incident case of PD. The study population was mostly male, less than 30 years old, enlisted, and in the Army or Navy. The overall incidence rate was 1.7 per 1,000 person-years. Prevalence of recurrence was 44.6% (2,494 of 5,598) and persistence was 50.1% (9,731 of 19,441). Overall, there were 115,387 medical encounters with a PD diagnosis during the study period, and service members in the top 25% for healthcare utilization had ≥11 encounters with a PD diagnosis.</p><p><strong>Conclusions: </strong>Pilonidal disease imposes a significant burden on the MHS and is a threat to overall force medical readiness. Treatment strategies remain heterogeneous, and prospective studies are needed to refine clinical guidelines.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica A Lutgendorf, Katherine C Walker-Rodriquez, Tony T Yuan, Wenyaw C Chan, Karen L Weis
Introduction: Unintended pregnancy is linked to maternal depression, substance use, late prenatal care, low birthweight, and preterm birth. Our objective was to examine the incidence of unintended pregnancies in the military, the effects on maternal mental health and the effects of Social Determinants of Health (SDOH).
Materials and methods: This was an institutional research board-approved secondary analysis of two independent military datasets of pregnant individuals participating in two prospective clinical trials of a pregnancy mentorship program, collected 2012-2017 (n = 246) and 2018-2022 (n = 1,523), and compared to assess relationships of SDOH and maternal mental health measures for those with and without intended pregnancies.
Results: The rate of unintended pregnancy reported by participants was higher, 42.8% in 2012-2017 compared to 34.4% in 2018-2022. The rates of unintended pregnancy in both periods were lower than the national average and was lower in the second study period compared to the first. There were significantly higher scores for both anxiety and depression for those with unintended pregnancies, regardless of the sample. Over the same periods, the perception of support (as measured by the social support index) was higher in 2012-2017 compared to 2018-2022. Although the measures do not significantly differ by age, military branch, or rank, there was a significant relationship between the level of education and a lower rate of unintended pregnancy.
Conclusion: Exploration of Military Health System pregnancy data is important as it provides one of the best pictures of family and force readiness. The recent issue of unintended pregnancy and the increasing incidence of depression and anxiety, with lowered perceived support have long-term implications for the overall health and well-being of the U.S. military force, which demands continued investigation.
{"title":"Intended and Unintended Pregnancies: Social Determinants and Pregnancy Mental Health from a Decade of Military Research.","authors":"Monica A Lutgendorf, Katherine C Walker-Rodriquez, Tony T Yuan, Wenyaw C Chan, Karen L Weis","doi":"10.1093/milmed/usaf648","DOIUrl":"https://doi.org/10.1093/milmed/usaf648","url":null,"abstract":"<p><strong>Introduction: </strong>Unintended pregnancy is linked to maternal depression, substance use, late prenatal care, low birthweight, and preterm birth. Our objective was to examine the incidence of unintended pregnancies in the military, the effects on maternal mental health and the effects of Social Determinants of Health (SDOH).</p><p><strong>Materials and methods: </strong>This was an institutional research board-approved secondary analysis of two independent military datasets of pregnant individuals participating in two prospective clinical trials of a pregnancy mentorship program, collected 2012-2017 (n = 246) and 2018-2022 (n = 1,523), and compared to assess relationships of SDOH and maternal mental health measures for those with and without intended pregnancies.</p><p><strong>Results: </strong>The rate of unintended pregnancy reported by participants was higher, 42.8% in 2012-2017 compared to 34.4% in 2018-2022. The rates of unintended pregnancy in both periods were lower than the national average and was lower in the second study period compared to the first. There were significantly higher scores for both anxiety and depression for those with unintended pregnancies, regardless of the sample. Over the same periods, the perception of support (as measured by the social support index) was higher in 2012-2017 compared to 2018-2022. Although the measures do not significantly differ by age, military branch, or rank, there was a significant relationship between the level of education and a lower rate of unintended pregnancy.</p><p><strong>Conclusion: </strong>Exploration of Military Health System pregnancy data is important as it provides one of the best pictures of family and force readiness. The recent issue of unintended pregnancy and the increasing incidence of depression and anxiety, with lowered perceived support have long-term implications for the overall health and well-being of the U.S. military force, which demands continued investigation.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maegan M Paxton Willing, Jaime Rodden, Ariana R Bazzi, Sebastian Preilipper, Linda Thompson
Survey research has long been a cornerstone of behavioral health and medical research. With the growth of Internet-based survey platforms, accelerated by the COVID-19 pandemic, conducting surveys completely online has become the standard. Online surveys provide the field with a fast, cost-effective method for gaining insights into relationships among health variables or in obtaining preliminary data to inform larger-scale studies. Additionally, online surveys enable researchers to recruit from a larger geographical area, thus increasing the generalizability of findings and, importantly, allowing participants to complete study activities completely de-identified. Although participating anonymously can increase one's comfort with disclosing sensitive or stigmatizing information, this can pose significant challenges to ensuring the legitimacy of participants' eligibility. This may be particularly true when compensation is available, increasing the likelihood of a prospective participant falsely reporting characteristics such as current or former military service. The following commentary provides an overview of the current landscape for researchers conducting military-related research via online surveys, with a specific emphasis on challenges in ensuring participants have a military background. In support of this, we present several real-world challenges for conducting de-identified online surveys, such as difficulties ensuring participants have a military background and preventing the use of "bots." Additionally, the evolving challenge of artificial intelligence is discussed in the context of its impact on knowledge-based screening methods such as the Military Screener Questionnaire. Alternative approaches, such as compensated screening surveys, are presented. Surveys will continue to be an important tool for advancing military medical research; however, researchers must discuss findings within the context of the inherent limitations of the methodology. The field should carefully monitor the evolving challenges to conducting online surveys.
{"title":"A Critical Look at the Challenges of Conducting de-Identified Military Surveys.","authors":"Maegan M Paxton Willing, Jaime Rodden, Ariana R Bazzi, Sebastian Preilipper, Linda Thompson","doi":"10.1093/milmed/usaf633","DOIUrl":"https://doi.org/10.1093/milmed/usaf633","url":null,"abstract":"<p><p>Survey research has long been a cornerstone of behavioral health and medical research. With the growth of Internet-based survey platforms, accelerated by the COVID-19 pandemic, conducting surveys completely online has become the standard. Online surveys provide the field with a fast, cost-effective method for gaining insights into relationships among health variables or in obtaining preliminary data to inform larger-scale studies. Additionally, online surveys enable researchers to recruit from a larger geographical area, thus increasing the generalizability of findings and, importantly, allowing participants to complete study activities completely de-identified. Although participating anonymously can increase one's comfort with disclosing sensitive or stigmatizing information, this can pose significant challenges to ensuring the legitimacy of participants' eligibility. This may be particularly true when compensation is available, increasing the likelihood of a prospective participant falsely reporting characteristics such as current or former military service. The following commentary provides an overview of the current landscape for researchers conducting military-related research via online surveys, with a specific emphasis on challenges in ensuring participants have a military background. In support of this, we present several real-world challenges for conducting de-identified online surveys, such as difficulties ensuring participants have a military background and preventing the use of \"bots.\" Additionally, the evolving challenge of artificial intelligence is discussed in the context of its impact on knowledge-based screening methods such as the Military Screener Questionnaire. Alternative approaches, such as compensated screening surveys, are presented. Surveys will continue to be an important tool for advancing military medical research; however, researchers must discuss findings within the context of the inherent limitations of the methodology. The field should carefully monitor the evolving challenges to conducting online surveys.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel T Wright, Jacob B Lindheimer, Israel C Christie, Jaraad Ramkissoon, Shaili Bhavsar, Rosalinda Desrochers, Walter W Frauman, Drew A Helmer
<p><strong>Introduction: </strong>Military personnel encounter a wide range of environmental and occupational exposures during their service such as burn pit smoke, chemical warfare agents, depleted uranium, jet fuel, radiation, and pesticides. The field of military exposures research seeks to better understand the nature of these exposures and their effects on Veteran and service member health. This state-of-the-art review assesses the breadth and depth of published military exposures research so that stakeholders can identify trends and gaps in this growing field.</p><p><strong>Materials and methods: </strong>An evidence mapping approach was used to perform a literature review of military exposures research published from 1962 to 2024. The search strategy was developed around exposed cohorts: groups of military personnel with a shared potential for exposure to toxic agents. Publications were included if they directly addressed exposures or related health outcomes in military cohorts. Publications were then further categorized by the type of research, and the results were analyzed to build a map of the current military exposures research landscape.</p><p><strong>Results: </strong>Thirty-six exposed cohorts were identified in the literature which were then grouped based on the nature of the exposure event: Wars and Operations (4 cohorts), Occupational Exposures (5), Combat and Combat Training (2), Across Military (2), Ship Exposures (2), Defense Testing (2), Base/Garrison Exposures (9), Toxic Substance Clean-Up and Disposal (5), and Isolated Exposure Events (5). The search identified 2,321 publications that fit the review inclusion criteria. The exposed cohort with the highest number of publications was Gulf War (940, 40.5% of all publications) followed by Vietnam War (277, 11.9%), Post-9/11 Operations in Iraq and Afghanistan (191, 8.2%), Aircraft Mechanics and Ground Support (176, 7.6%), and Munition Emissions and Embedded Fragments (164, 7.1%). Each remaining cohort individually represented < 4% of the literature. Six cohorts appeared only in non-peer-reviewed reports. The type of research best represented was Epidemiology (34.0%) followed by Animal and In Vitro Models (18.8%), Sequelae and Management (17.1%), Reviews and Meta-Analyses (11.7%), Exposure Assessment (9.5%), Toxic Agent Sampling and Analysis (4.3%), and publications from the National Academy of Sciences, Engineering, and Medicine (4.6%). The volume of military exposures research has increased steadily since the early public reports of Gulf War Illness in 1994, with 50% of articles being published after 2008.</p><p><strong>Conclusion: </strong>Military exposures research published since 1962 has focused on cohorts from large, high-profile deployments, particularly the Gulf War. Underrepresented cohorts with potential exposures on bases or from military occupations present opportunities for future research. The lack of meaningful exposure assessment data that has been published also
{"title":"Military Exposures Research: A State-of-the-Art Review.","authors":"Rachel T Wright, Jacob B Lindheimer, Israel C Christie, Jaraad Ramkissoon, Shaili Bhavsar, Rosalinda Desrochers, Walter W Frauman, Drew A Helmer","doi":"10.1093/milmed/usaf647","DOIUrl":"10.1093/milmed/usaf647","url":null,"abstract":"<p><strong>Introduction: </strong>Military personnel encounter a wide range of environmental and occupational exposures during their service such as burn pit smoke, chemical warfare agents, depleted uranium, jet fuel, radiation, and pesticides. The field of military exposures research seeks to better understand the nature of these exposures and their effects on Veteran and service member health. This state-of-the-art review assesses the breadth and depth of published military exposures research so that stakeholders can identify trends and gaps in this growing field.</p><p><strong>Materials and methods: </strong>An evidence mapping approach was used to perform a literature review of military exposures research published from 1962 to 2024. The search strategy was developed around exposed cohorts: groups of military personnel with a shared potential for exposure to toxic agents. Publications were included if they directly addressed exposures or related health outcomes in military cohorts. Publications were then further categorized by the type of research, and the results were analyzed to build a map of the current military exposures research landscape.</p><p><strong>Results: </strong>Thirty-six exposed cohorts were identified in the literature which were then grouped based on the nature of the exposure event: Wars and Operations (4 cohorts), Occupational Exposures (5), Combat and Combat Training (2), Across Military (2), Ship Exposures (2), Defense Testing (2), Base/Garrison Exposures (9), Toxic Substance Clean-Up and Disposal (5), and Isolated Exposure Events (5). The search identified 2,321 publications that fit the review inclusion criteria. The exposed cohort with the highest number of publications was Gulf War (940, 40.5% of all publications) followed by Vietnam War (277, 11.9%), Post-9/11 Operations in Iraq and Afghanistan (191, 8.2%), Aircraft Mechanics and Ground Support (176, 7.6%), and Munition Emissions and Embedded Fragments (164, 7.1%). Each remaining cohort individually represented < 4% of the literature. Six cohorts appeared only in non-peer-reviewed reports. The type of research best represented was Epidemiology (34.0%) followed by Animal and In Vitro Models (18.8%), Sequelae and Management (17.1%), Reviews and Meta-Analyses (11.7%), Exposure Assessment (9.5%), Toxic Agent Sampling and Analysis (4.3%), and publications from the National Academy of Sciences, Engineering, and Medicine (4.6%). The volume of military exposures research has increased steadily since the early public reports of Gulf War Illness in 1994, with 50% of articles being published after 2008.</p><p><strong>Conclusion: </strong>Military exposures research published since 1962 has focused on cohorts from large, high-profile deployments, particularly the Gulf War. Underrepresented cohorts with potential exposures on bases or from military occupations present opportunities for future research. The lack of meaningful exposure assessment data that has been published also","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia A Lytle, Andrew J Kittelson, Tyler Cardinale, Trevor Kingsbury, Eric Infante, Joshua D Winters, Brian J Loyd
<p><strong>Introduction: </strong>The vestibular system plays a critical role in maintaining gaze stability during head movement, a function largely controlled by the vestibulo-ocular reflex (VOR). When the VOR is impaired, individuals may experience blurred vision, dizziness, and other symptoms that interfere with daily activities. Dynamic visual acuity (DVA), or the ability to clearly identify a visual target during head movement, provides a functional measure of VOR performance and can be assessed using computerized tools. Military aviators are frequently exposed to situations that place high demands on the vestibular system. This study aims to evaluate DVA among rotary wing Naval aviators, hypothesizing that pilots would demonstrate superior DVA relative to non-pilot personnel. A secondary aim was to explore the relationship between flight hours and DVA performance in pilots, along with evaluation of other demographics.</p><p><strong>Materials and methods: </strong>This study included 96 participants, 58 rotary wing pilots and 38 non-pilot maintenance crew members, from Naval Air Station North Island and Marine Corps Air Station (MCAS) Miramar. All participants were active duty service members who voluntarily completed a DVA assessment under the Naval Medical Center San Diego IRB protocol NMCSD.2021.005 as a part of a larger clinical human performance program. Participation was open regardless of age or sex, and recruitment occurred through word of mouth via squadron leadership and Naval Medical Center San Diego (NMCSD) briefs. Dynamic visual acuity was assessed using a computerized test validated in previous NIH Toolbox studies. This required static head movements and horizontal head movements that exceeded 180 deg/sec while identifying briefly presented optotypes. Independent t-tests and chi-square tests were used to compare demographics and visual acuity between groups. A linear model controlled for age and static acuity when comparing DVA scores. Among pilots, Pearson correlation assessed the relationship between flight hours and DVA.</p><p><strong>Results: </strong>There were no significant differences in demographics or static visual acuity between pilots and non-pilots. Pilots demonstrated significantly better DVA (0.15 ± 0.08 LogMAR) than non-pilots (0.22 ± 0.22 LogMAR), even when adjusted for age and static acuity (P = .01). Static acuity was strongly related to DVA (Beta = 0.65, P < .0001), whereas age was not. Among pilots, flight hours (mean = 916 ± 748 hours) were not correlated with DVA performance.</p><p><strong>Conclusions: </strong>This study found that rotary wing Naval aviators exhibit superior DVA compared to non-pilots. These findings highlight potential vestibulo-ocular adaptations potentially from the constant occupational demands of aviation or because of the competitive selection process Naval aviators face. Although no correlation was found between flight hours and DVA, further longitudinal studies are needed to clar
{"title":"A Comparative Study of Vestibular Performance in Pilot and Non-Pilot Service Members in Naval Aviation.","authors":"Julia A Lytle, Andrew J Kittelson, Tyler Cardinale, Trevor Kingsbury, Eric Infante, Joshua D Winters, Brian J Loyd","doi":"10.1093/milmed/usaf604","DOIUrl":"https://doi.org/10.1093/milmed/usaf604","url":null,"abstract":"<p><strong>Introduction: </strong>The vestibular system plays a critical role in maintaining gaze stability during head movement, a function largely controlled by the vestibulo-ocular reflex (VOR). When the VOR is impaired, individuals may experience blurred vision, dizziness, and other symptoms that interfere with daily activities. Dynamic visual acuity (DVA), or the ability to clearly identify a visual target during head movement, provides a functional measure of VOR performance and can be assessed using computerized tools. Military aviators are frequently exposed to situations that place high demands on the vestibular system. This study aims to evaluate DVA among rotary wing Naval aviators, hypothesizing that pilots would demonstrate superior DVA relative to non-pilot personnel. A secondary aim was to explore the relationship between flight hours and DVA performance in pilots, along with evaluation of other demographics.</p><p><strong>Materials and methods: </strong>This study included 96 participants, 58 rotary wing pilots and 38 non-pilot maintenance crew members, from Naval Air Station North Island and Marine Corps Air Station (MCAS) Miramar. All participants were active duty service members who voluntarily completed a DVA assessment under the Naval Medical Center San Diego IRB protocol NMCSD.2021.005 as a part of a larger clinical human performance program. Participation was open regardless of age or sex, and recruitment occurred through word of mouth via squadron leadership and Naval Medical Center San Diego (NMCSD) briefs. Dynamic visual acuity was assessed using a computerized test validated in previous NIH Toolbox studies. This required static head movements and horizontal head movements that exceeded 180 deg/sec while identifying briefly presented optotypes. Independent t-tests and chi-square tests were used to compare demographics and visual acuity between groups. A linear model controlled for age and static acuity when comparing DVA scores. Among pilots, Pearson correlation assessed the relationship between flight hours and DVA.</p><p><strong>Results: </strong>There were no significant differences in demographics or static visual acuity between pilots and non-pilots. Pilots demonstrated significantly better DVA (0.15 ± 0.08 LogMAR) than non-pilots (0.22 ± 0.22 LogMAR), even when adjusted for age and static acuity (P = .01). Static acuity was strongly related to DVA (Beta = 0.65, P < .0001), whereas age was not. Among pilots, flight hours (mean = 916 ± 748 hours) were not correlated with DVA performance.</p><p><strong>Conclusions: </strong>This study found that rotary wing Naval aviators exhibit superior DVA compared to non-pilots. These findings highlight potential vestibulo-ocular adaptations potentially from the constant occupational demands of aviation or because of the competitive selection process Naval aviators face. Although no correlation was found between flight hours and DVA, further longitudinal studies are needed to clar","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trenton M Haltom, Timothy Zhou, Lindsay Vaclavik, Kayla Grimes, Israel C Christie, Kyler M Godwin, Drew A Helmer
Introduction: The Airborne Hazards and Open Burn Pits Registry (AHOBPR) examination was a service for Veterans with concerns about environmental exposures during military deployments. Interested Veterans enrolled in the AHOBPR online, completed a questionnaire, and indicated interest in a clinical examination by a Veterans Health Administration clinician. Several factors (e.g., COVID, unanticipated demand, and personnel turnover) resulted in a large number of pending examinations nationwide by 2022, prompting an evaluation and implementation effort to accelerate completion of high-quality examinations.Our objective was to assess Veterans' and clinical team members' perspectives of AHOBPR examinations to improve their delivery.
Meterials and methods: Qualitative interviews with Veterans who had completed an AHOBPR examination and clinical team members (CTMs) at 2 Veterans Affairs (VA) sites participating in our implementation. We recruited Veterans within 6 months of completing their examination and home facility complexity and performance metrics. We recruited CTMs for interviews from 2 purposefully selected VA facilities that completed all assessments conducted by our implementation team. Interviews were conducted between September 2022 and January 2023. We analyzed transcripts using rapid analysis. We apply the Promoting Action on Research Implementation in Health Service (PARiHS) framework to inform our interpretation of findings.
Results: Twenty-one Veterans and 9 CTMs from 2 sites completed interviews. Themes identified in the interviews were consistent with the PARiHS elements of evidence, context, and facilitation. Both Veterans and CTMs wanted evidence of appropriate knowledge about the AHOBPR and deployment and understanding AHOBPR structures and facility processes, including appropriate documentation of Veteran concerns. Contextually, Veterans and CTMs shared their strategies or experiences in clinical interactions especially the focus on developing patient-provider rapport and being prepared for examinations. Examples of facilitation included both groups' personal and professional motivations for conducting or pursuing examinations. Facilitation also involved local administrators and leaders providing the necessary staff, support, and resources.
Conclusions: Assessing Veteran and clinical team member (CTM) perceptions of AHOBPR examinations revealed clinically relevant opportunities important to addressing military and environmental exposure concerns of veterans (i.e., "exposure-informed care"). Clinical leaders can use the PARiHS framework and lessons learned from the AHOBPR experience to assess implementation and improve delivery of other novel services.
{"title":"Lessons Learned From a Nationwide Implementation of Airborne Hazards and Open Burn Pits Registry Clinical Examinations: A Qualitative Assessment.","authors":"Trenton M Haltom, Timothy Zhou, Lindsay Vaclavik, Kayla Grimes, Israel C Christie, Kyler M Godwin, Drew A Helmer","doi":"10.1093/milmed/usaf651","DOIUrl":"https://doi.org/10.1093/milmed/usaf651","url":null,"abstract":"<p><strong>Introduction: </strong>The Airborne Hazards and Open Burn Pits Registry (AHOBPR) examination was a service for Veterans with concerns about environmental exposures during military deployments. Interested Veterans enrolled in the AHOBPR online, completed a questionnaire, and indicated interest in a clinical examination by a Veterans Health Administration clinician. Several factors (e.g., COVID, unanticipated demand, and personnel turnover) resulted in a large number of pending examinations nationwide by 2022, prompting an evaluation and implementation effort to accelerate completion of high-quality examinations.Our objective was to assess Veterans' and clinical team members' perspectives of AHOBPR examinations to improve their delivery.</p><p><strong>Meterials and methods: </strong>Qualitative interviews with Veterans who had completed an AHOBPR examination and clinical team members (CTMs) at 2 Veterans Affairs (VA) sites participating in our implementation. We recruited Veterans within 6 months of completing their examination and home facility complexity and performance metrics. We recruited CTMs for interviews from 2 purposefully selected VA facilities that completed all assessments conducted by our implementation team. Interviews were conducted between September 2022 and January 2023. We analyzed transcripts using rapid analysis. We apply the Promoting Action on Research Implementation in Health Service (PARiHS) framework to inform our interpretation of findings.</p><p><strong>Results: </strong>Twenty-one Veterans and 9 CTMs from 2 sites completed interviews. Themes identified in the interviews were consistent with the PARiHS elements of evidence, context, and facilitation. Both Veterans and CTMs wanted evidence of appropriate knowledge about the AHOBPR and deployment and understanding AHOBPR structures and facility processes, including appropriate documentation of Veteran concerns. Contextually, Veterans and CTMs shared their strategies or experiences in clinical interactions especially the focus on developing patient-provider rapport and being prepared for examinations. Examples of facilitation included both groups' personal and professional motivations for conducting or pursuing examinations. Facilitation also involved local administrators and leaders providing the necessary staff, support, and resources.</p><p><strong>Conclusions: </strong>Assessing Veteran and clinical team member (CTM) perceptions of AHOBPR examinations revealed clinically relevant opportunities important to addressing military and environmental exposure concerns of veterans (i.e., \"exposure-informed care\"). Clinical leaders can use the PARiHS framework and lessons learned from the AHOBPR experience to assess implementation and improve delivery of other novel services.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marion Legay, Guillaume Vanderperre, Anaelle Leroux, Emilie Roméo, Matthieu Patient, Christophe Dubecq, Jean Sébastien Bladé, Henri de Lesquen, Laurys Boudin
Introduction: Notifying a patient's family that the patient has died is a delicate and sensitive task in medical practice. This is particularly true in the military population due to the frequent unexpected and sudden nature of death. Medical students in France receive no systematic training in death notification, either in civilian or military settings. Therefore, the researchers sought to (1) assess the initial level of training of military medical residents in announcing death, (2) design an adapted simulation-based training program after the observation of possible gaps, (3) evaluate its impact on their perceived self-efficacy, and (4) assess the program's long-term relevance.
Materials and methods: The researchers conducted an observational study followed by a simulation-based educational intervention. First, a questionnaire was distributed to two cohorts of military medical residents, who began their residency in 2023 and 2024. The questionnaire assessed their training level, experience, and perceptions regarding death announcement. Based on the findings, a tailored theoretical and practical simulation-based training was developed and delivered. Pre- and post-training self-assessment questionnaires and a 5-month follow-up survey were used to evaluate the impact and retention of learning outcomes.
Results: A total of 72 residents (45%) completed the initial questionnaire. The mean age of the participants was 25 ± 1.5 years, and 61% of the respondents were female. Most participants (57/72, 79%) specialized in general practice. Only 19% (14/72) had previously announced a death, and 44% (32/72) declared that they had received some form of related training during their curriculum, which was simulation-based for 35% (25/72). Of the 14 residents who had to announce a death, 9 (65%) felt little or not at all prepared. Overall, 40 residents participated in the simulation-based training, which led to a statistically significant improvement (P < .05) in eight out of 10 assessed skills. At 5-month follow-up, all residents who had to deliver a death notification reported the training as useful.
Conclusions: The initial assessment revealed a clear need for specialized training in announcing death for future military physicians. The implemented simulation-based program significantly enhanced the residents' sense of self-efficacy. There is strong support for integrating the program into the curriculum annually, as it appears to effectively improve the quality of care provided to grieving families.
{"title":"Initial Evaluation and Implementation of Simulation-based Death Notification Training for Military Residents.","authors":"Marion Legay, Guillaume Vanderperre, Anaelle Leroux, Emilie Roméo, Matthieu Patient, Christophe Dubecq, Jean Sébastien Bladé, Henri de Lesquen, Laurys Boudin","doi":"10.1093/milmed/usaf649","DOIUrl":"https://doi.org/10.1093/milmed/usaf649","url":null,"abstract":"<p><strong>Introduction: </strong>Notifying a patient's family that the patient has died is a delicate and sensitive task in medical practice. This is particularly true in the military population due to the frequent unexpected and sudden nature of death. Medical students in France receive no systematic training in death notification, either in civilian or military settings. Therefore, the researchers sought to (1) assess the initial level of training of military medical residents in announcing death, (2) design an adapted simulation-based training program after the observation of possible gaps, (3) evaluate its impact on their perceived self-efficacy, and (4) assess the program's long-term relevance.</p><p><strong>Materials and methods: </strong>The researchers conducted an observational study followed by a simulation-based educational intervention. First, a questionnaire was distributed to two cohorts of military medical residents, who began their residency in 2023 and 2024. The questionnaire assessed their training level, experience, and perceptions regarding death announcement. Based on the findings, a tailored theoretical and practical simulation-based training was developed and delivered. Pre- and post-training self-assessment questionnaires and a 5-month follow-up survey were used to evaluate the impact and retention of learning outcomes.</p><p><strong>Results: </strong>A total of 72 residents (45%) completed the initial questionnaire. The mean age of the participants was 25 ± 1.5 years, and 61% of the respondents were female. Most participants (57/72, 79%) specialized in general practice. Only 19% (14/72) had previously announced a death, and 44% (32/72) declared that they had received some form of related training during their curriculum, which was simulation-based for 35% (25/72). Of the 14 residents who had to announce a death, 9 (65%) felt little or not at all prepared. Overall, 40 residents participated in the simulation-based training, which led to a statistically significant improvement (P < .05) in eight out of 10 assessed skills. At 5-month follow-up, all residents who had to deliver a death notification reported the training as useful.</p><p><strong>Conclusions: </strong>The initial assessment revealed a clear need for specialized training in announcing death for future military physicians. The implemented simulation-based program significantly enhanced the residents' sense of self-efficacy. There is strong support for integrating the program into the curriculum annually, as it appears to effectively improve the quality of care provided to grieving families.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: In recent years, there has been increased recognition and awareness surrounding mental health among US military personnel. However, the prevalence of postpartum depression (PPD) among female service members is significantly higher than that of the general US population. There is currently a gap in the literature characterizing the unique factors of the military experience accounting for the higher predisposition to PPD relative to civilian Americans. This qualitative review aims to address this gap by isolating risk factors which have been consistently identified in the available literature as contributing to the prevalence discrepancy.
Materials and methods: A MeSH database-built search utilizing key terms "postpartum depression" and "military" was used to gather sources that fit the inclusion criteria. These sources were analyzed for explicitly identified PPD risk factors pertaining to US military personnel and spouses.
Results: Of the 14 sources meeting inclusion criteria, a history of a mental health disorder and a lack of social support were identified in seven distinct articles as significant risk factors for PPD among military personnel. Low rank and pay, as well as deployments of self and/or spouse, were specified in six papers. A history of depression, history of anxiety, and exposure to combat were identified in five papers. Four papers isolated branch of service and young age as risk factors. Factors that were recognized in three papers or less included, but are not limited to: tobacco use, history of PTSD, history of sexual assault, low education attainment, high number of child dependents, race, and job stress.
Conclusions: Women in the military and spouses of military personnel are subject to an environment with distinct stressors, increasing their predisposition for PPD. Identifying specific risk factors is critical for quality screening, diagnosis, and care of PPD among this population. Significant risk factors consistently isolated from the available literature include history of mental health disorders, lack of adequate social support, low rank and pay, deployment of self or spouse, history of combat exposure, branch of service, and young maternal age. Findings of this review also suggest that early detection via thorough screening and disease mitigation by means of a 12-week maternity leave led to lower rates of PPD and better disease outcomes. Military-specific family health resources are widely available across branches of service and individual bases, though the use and quality of these resources are inconsistent. Providers of women experiencing at least one of these stressors should increase PPD precautions and refer patients to the appropriate preventative and acute care.
{"title":"A Scoping Review of Risk Factors of Postpartum Depression among Military Personnel and Spouses.","authors":"Catherine Biegel, Hailee Poulin, Sophia Silvia, Geoffrey McCullen","doi":"10.1093/milmed/usag005","DOIUrl":"https://doi.org/10.1093/milmed/usag005","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, there has been increased recognition and awareness surrounding mental health among US military personnel. However, the prevalence of postpartum depression (PPD) among female service members is significantly higher than that of the general US population. There is currently a gap in the literature characterizing the unique factors of the military experience accounting for the higher predisposition to PPD relative to civilian Americans. This qualitative review aims to address this gap by isolating risk factors which have been consistently identified in the available literature as contributing to the prevalence discrepancy.</p><p><strong>Materials and methods: </strong>A MeSH database-built search utilizing key terms \"postpartum depression\" and \"military\" was used to gather sources that fit the inclusion criteria. These sources were analyzed for explicitly identified PPD risk factors pertaining to US military personnel and spouses.</p><p><strong>Results: </strong>Of the 14 sources meeting inclusion criteria, a history of a mental health disorder and a lack of social support were identified in seven distinct articles as significant risk factors for PPD among military personnel. Low rank and pay, as well as deployments of self and/or spouse, were specified in six papers. A history of depression, history of anxiety, and exposure to combat were identified in five papers. Four papers isolated branch of service and young age as risk factors. Factors that were recognized in three papers or less included, but are not limited to: tobacco use, history of PTSD, history of sexual assault, low education attainment, high number of child dependents, race, and job stress.</p><p><strong>Conclusions: </strong>Women in the military and spouses of military personnel are subject to an environment with distinct stressors, increasing their predisposition for PPD. Identifying specific risk factors is critical for quality screening, diagnosis, and care of PPD among this population. Significant risk factors consistently isolated from the available literature include history of mental health disorders, lack of adequate social support, low rank and pay, deployment of self or spouse, history of combat exposure, branch of service, and young maternal age. Findings of this review also suggest that early detection via thorough screening and disease mitigation by means of a 12-week maternity leave led to lower rates of PPD and better disease outcomes. Military-specific family health resources are widely available across branches of service and individual bases, though the use and quality of these resources are inconsistent. Providers of women experiencing at least one of these stressors should increase PPD precautions and refer patients to the appropriate preventative and acute care.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Neveills, Marguerite Engler, Catherine Battaglia, Laura Kaizer, Madhura Gokhale, Robert Leonard
<p><strong>Introduction: </strong>United States Veterans who served in Vietnam, the Korean Demilitarized Zone, or Thailand Air Force bases from 1962 to 1971 were likely exposed to Agent Orange, as approximately 107 million pounds of the chemical were sprayed in the areas where the fighting occurred. Agent Orange was an herbicide used by the United States military to kill the jungle, foliage, tall grasses, bushes, and weeds. Agent Orange contained 2,3,7,8-tetrachlorodibenzo-p-dioxin, the most toxic form of dioxin, which has been associated with multiple disease processes and cardiac issues.</p><p><strong>Materials and methods: </strong>An original quantitative descriptive, retrospective cohort, secondary data analysis study was conducted utilizing data collected by the Veterans Health Administration (VHA) via the Cardiovascular Assessment, Reporting, and Tracking System for Cath Labs and the Computerized Patient Record System. A new and innovative Structured Query Language report was created for data mining. Statistical tests included Chi-square tests, two-sample t-tests, prevalence, logistic regression, and odds ratios. A secondary analysis was conducted to assess for confounders, associations, and differences.</p><p><strong>Results: </strong>Veterans exposed to Agent Orange status post (s/p) percutaneous coronary intervention (PCI) have significantly higher body mass index (P ≤ .01), with a higher percentage of obesity (45.4% vs. 41.0%) and severe obesity (7.0% vs. 6.1%). There is a higher prevalence of those exposed to Agent Orange in the white (85% vs. 79.3%, P ≤ .01) and non-Hispanic/Latino (93.9% vs. 92.9%, P ≤ .01) male population. There is a higher prevalence of hypertension (91.3% vs. 90.7%, P = .03), hyperlipidemia (91.7% vs. 90.1%, P ≤ .01), and diabetes (53.5% vs. 49.8%, P ≤ .01) in those exposed vs. non-exposed. Lastly, there is a higher prevalence (1.8% vs. 1.5%) and fully adjusted odds 1.22 (95%CI: 1.08, 1.37; P = .0011) of coronary artery bypass graft surgery (CABG).</p><p><strong>Conclusions: </strong>Veterans exposed to Agent Orange are high-risk cardiovascular patients with a higher prevalence and odds of CABG s/p PCI. The increased prevalence of hypertension, hyperlipidemia, obesity, severe obesity, and diabetes in Veterans exposed to Agent Orange s/p PCI suggests that Agent Orange may contribute to the development of these disease processes. Strengths include the quality and longevity of the data collected, the Promise to Address Comprehensive Toxics (PACT) Act supporting Agent Orange research, and the advanced age of the Veterans increases the likelihood of cardiovascular disease. Weaknesses include the inability to quantify and confirm Agent Orange exposure, the inability to determine causation, and the VHA registrar's office could have erroneously assigned the Agent Orange disability flag by not verifying the service location. This study impacts the care of the Veterans s/p PCI; providers should assess the comorbidities, co
简介:1962年至1971年间在越南、朝鲜非军事区或泰国空军基地服役的美国退伍军人可能接触过橙剂,大约1.07亿磅的化学物质被喷洒在战斗发生的地区。橙剂是美国军方使用的一种除草剂,用来杀死丛林、树叶、高草、灌木和杂草。橙剂含有2,3,7,8-四氯二苯并-对二恶英,这是二恶英中毒性最大的一种,与多种疾病进程和心脏问题有关。材料和方法:一项原始的定量描述性、回顾性队列、二次数据分析研究利用退伍军人健康管理局(VHA)通过导管实验室心血管评估、报告和跟踪系统和计算机化患者记录系统收集的数据进行。为数据挖掘创建了一个新的、创新的结构化查询语言报告。统计检验包括卡方检验、双样本t检验、患病率、logistic回归和优势比。进行二次分析以评估混杂因素、关联和差异。结果:暴露于橙剂的退伍军人经皮冠状动脉介入治疗(PCI)后状态(s/p)体重指数(p≤。01),肥胖比例(45.4%比41.0%)和重度肥胖比例(7.0%比6.1%)更高。接触过橙剂的白人患病率较高(85% vs. 79.3%, P≤。01)和非西班牙裔/拉丁裔(93.9% vs. 92.9%, P≤。01)男性人口。高血压患病率较高(91.3% vs. 90.7%, P =。03)、高脂血症(91.7% vs. 90.1%, P≤。01),糖尿病(53.5% vs 49.8%, P≤。01)。最后,有更高的患病率(1.8%比1.5%)和完全调整的优势1.22 (95%CI: 1.08, 1.37; P =。0011)冠状动脉搭桥手术(CABG)。结论:暴露于橙剂的退伍军人是高危心血管患者,CABG /p PCI的患病率和几率较高。暴露于橙剂s/p PCI的退伍军人中高血压、高脂血症、肥胖、严重肥胖和糖尿病患病率的增加表明橙剂可能有助于这些疾病的发展。其优势包括所收集数据的质量和寿命,《解决全面有毒物质承诺法案》(PACT)支持橙剂研究,以及退伍军人的高龄增加了患心血管疾病的可能性。缺点包括无法量化和确认橙剂暴露,无法确定因果关系,并且VHA注册办公室可能由于未验证服务位置而错误地分配了橙剂残疾标志。本研究对退伍军人s/p PCI护理的影响;提供者应评估合并症、冠状动脉疾病进展、受影响的血管数量、心脏血管扭曲程度、冠状动脉病变位置、病变大小和所需支架数量,以确定重复PCI是否优于CABG治疗。未来的研究应包括PACT法案筛查中暴露于橙剂的新分类退伍军人,CABG结果,冠状动脉病变特征,支架类型以及最初PCI时处方的药物。
{"title":"Major Adverse Coronary Events Status Post Percutaneous Coronary Intervention in Veterans Exposed to Agent Orange Versus Non-Exposed.","authors":"Sarah Neveills, Marguerite Engler, Catherine Battaglia, Laura Kaizer, Madhura Gokhale, Robert Leonard","doi":"10.1093/milmed/usaf627","DOIUrl":"https://doi.org/10.1093/milmed/usaf627","url":null,"abstract":"<p><strong>Introduction: </strong>United States Veterans who served in Vietnam, the Korean Demilitarized Zone, or Thailand Air Force bases from 1962 to 1971 were likely exposed to Agent Orange, as approximately 107 million pounds of the chemical were sprayed in the areas where the fighting occurred. Agent Orange was an herbicide used by the United States military to kill the jungle, foliage, tall grasses, bushes, and weeds. Agent Orange contained 2,3,7,8-tetrachlorodibenzo-p-dioxin, the most toxic form of dioxin, which has been associated with multiple disease processes and cardiac issues.</p><p><strong>Materials and methods: </strong>An original quantitative descriptive, retrospective cohort, secondary data analysis study was conducted utilizing data collected by the Veterans Health Administration (VHA) via the Cardiovascular Assessment, Reporting, and Tracking System for Cath Labs and the Computerized Patient Record System. A new and innovative Structured Query Language report was created for data mining. Statistical tests included Chi-square tests, two-sample t-tests, prevalence, logistic regression, and odds ratios. A secondary analysis was conducted to assess for confounders, associations, and differences.</p><p><strong>Results: </strong>Veterans exposed to Agent Orange status post (s/p) percutaneous coronary intervention (PCI) have significantly higher body mass index (P ≤ .01), with a higher percentage of obesity (45.4% vs. 41.0%) and severe obesity (7.0% vs. 6.1%). There is a higher prevalence of those exposed to Agent Orange in the white (85% vs. 79.3%, P ≤ .01) and non-Hispanic/Latino (93.9% vs. 92.9%, P ≤ .01) male population. There is a higher prevalence of hypertension (91.3% vs. 90.7%, P = .03), hyperlipidemia (91.7% vs. 90.1%, P ≤ .01), and diabetes (53.5% vs. 49.8%, P ≤ .01) in those exposed vs. non-exposed. Lastly, there is a higher prevalence (1.8% vs. 1.5%) and fully adjusted odds 1.22 (95%CI: 1.08, 1.37; P = .0011) of coronary artery bypass graft surgery (CABG).</p><p><strong>Conclusions: </strong>Veterans exposed to Agent Orange are high-risk cardiovascular patients with a higher prevalence and odds of CABG s/p PCI. The increased prevalence of hypertension, hyperlipidemia, obesity, severe obesity, and diabetes in Veterans exposed to Agent Orange s/p PCI suggests that Agent Orange may contribute to the development of these disease processes. Strengths include the quality and longevity of the data collected, the Promise to Address Comprehensive Toxics (PACT) Act supporting Agent Orange research, and the advanced age of the Veterans increases the likelihood of cardiovascular disease. Weaknesses include the inability to quantify and confirm Agent Orange exposure, the inability to determine causation, and the VHA registrar's office could have erroneously assigned the Agent Orange disability flag by not verifying the service location. This study impacts the care of the Veterans s/p PCI; providers should assess the comorbidities, co","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher J Scheiber, Sarah Glier, Justin Magin, Mark Hanlon, Matthew Vander Ploeg, Bryan Obika, Herman Freeman, Om Dave, Andrew Tolksdorf, Richard D Neading, Alexander Doyal, Alan Smeltz
Introduction: Military field medicine providers often operate in resource-limited environments where improvization with available equipment is essential. Whole blood transfusion has had significant benefits in treating severely injured trauma patients in these settings. Current protocols often mandate anticoagulant-containing intravenous (IV) fluid bags for fresh whole blood transfusion, which can pose logistical challenges for forward-placed medical units. This study explores the feasibility of using a syringe without anticoagulant as an alternative method.
Materials and methods: Whole blood was collected from healthy volunteer donors and divided into syringes with and without citrate-phosphate-dextrose (CPD) solution. Samples were stored for varying durations and infused through a standard IV setup to simulate transfusion conditions. To assess coagulation, infusion rate under standardized infusion pressure, clot mass, and coagulation parameters (PT/INR, PTT) was measured. Hemolysis was assessed by measuring plasma hemoglobin, potassium, lactate dehydrogenase (LDH), bilirubin pre- and post-infusion at either 100 mL/minute, 200 mL/minute or maximal manual compression.
Results: We performed a nested analysis of variance (ANOVA) analysis on coagulation and hemolysis parameters. Tukey post-hoc testing was used to determine mean subgroup differences. Analyses were carried out using R version 4.3.0 (R Core Team, 2024). Significant differences were observed in infusion rates across different storage times but not between CPD and non-CPD conditions. There was significantly greater clot burden in non-CPD groups compared to CPD at 30 minutes (6.5 ± 2.1 g) and 60 minutes (8.8 ± 1.9 g), but no significant difference was observed in the 30 second (0.001 ± 2.0 g) and 5 minute (1.1 ± 2.0 g) groups. Coagulation parameters (INR, PT, and PTT) showed no significant differences based on storage time but were impacted by the presence of CPD. Hemolysis markers indicated significant changes in plasma hemoglobin with higher infusion rates but no significant alterations in LDH, potassium, or bilirubin at any of the infusion rates.
Conclusions: These findings suggest that non-anticoagulated fresh whole blood may be transfused within 5 minutes at infusion rates of 100 mL/minute or less with no significant clot burden and no evidence of hemolysis. Longer storage times and faster infusion rates may also be clinical safe but require further investigation. This study indicates that there may be some potential use of this method in military units executing a fresh whole blood draw with short donor-to-recipient times.
{"title":"Non-Anticoagulated Fresh Whole Blood Syringe Transfusion as an Alternative for Military Hemorrhage Resuscitation in Austere Environments.","authors":"Christopher J Scheiber, Sarah Glier, Justin Magin, Mark Hanlon, Matthew Vander Ploeg, Bryan Obika, Herman Freeman, Om Dave, Andrew Tolksdorf, Richard D Neading, Alexander Doyal, Alan Smeltz","doi":"10.1093/milmed/usaf564","DOIUrl":"https://doi.org/10.1093/milmed/usaf564","url":null,"abstract":"<p><strong>Introduction: </strong>Military field medicine providers often operate in resource-limited environments where improvization with available equipment is essential. Whole blood transfusion has had significant benefits in treating severely injured trauma patients in these settings. Current protocols often mandate anticoagulant-containing intravenous (IV) fluid bags for fresh whole blood transfusion, which can pose logistical challenges for forward-placed medical units. This study explores the feasibility of using a syringe without anticoagulant as an alternative method.</p><p><strong>Materials and methods: </strong>Whole blood was collected from healthy volunteer donors and divided into syringes with and without citrate-phosphate-dextrose (CPD) solution. Samples were stored for varying durations and infused through a standard IV setup to simulate transfusion conditions. To assess coagulation, infusion rate under standardized infusion pressure, clot mass, and coagulation parameters (PT/INR, PTT) was measured. Hemolysis was assessed by measuring plasma hemoglobin, potassium, lactate dehydrogenase (LDH), bilirubin pre- and post-infusion at either 100 mL/minute, 200 mL/minute or maximal manual compression.</p><p><strong>Results: </strong>We performed a nested analysis of variance (ANOVA) analysis on coagulation and hemolysis parameters. Tukey post-hoc testing was used to determine mean subgroup differences. Analyses were carried out using R version 4.3.0 (R Core Team, 2024). Significant differences were observed in infusion rates across different storage times but not between CPD and non-CPD conditions. There was significantly greater clot burden in non-CPD groups compared to CPD at 30 minutes (6.5 ± 2.1 g) and 60 minutes (8.8 ± 1.9 g), but no significant difference was observed in the 30 second (0.001 ± 2.0 g) and 5 minute (1.1 ± 2.0 g) groups. Coagulation parameters (INR, PT, and PTT) showed no significant differences based on storage time but were impacted by the presence of CPD. Hemolysis markers indicated significant changes in plasma hemoglobin with higher infusion rates but no significant alterations in LDH, potassium, or bilirubin at any of the infusion rates.</p><p><strong>Conclusions: </strong>These findings suggest that non-anticoagulated fresh whole blood may be transfused within 5 minutes at infusion rates of 100 mL/minute or less with no significant clot burden and no evidence of hemolysis. Longer storage times and faster infusion rates may also be clinical safe but require further investigation. This study indicates that there may be some potential use of this method in military units executing a fresh whole blood draw with short donor-to-recipient times.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}