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Impact of Hypobaria and Hypoxia Exposure on Mortality, Inflammation, and Coagulopathy in an Animal Model of Polytrauma. 在多发性创伤动物模型中,低低压和低氧暴露对死亡率、炎症和凝血功能的影响。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-06 DOI: 10.1093/milmed/usag021
John Kessler Ii, Chanhee Park, Xiaomei Yang, Fengqian Chen, Arijit Duta, Lin Zou, Wei Chao, Brittney Williams
<p><strong>Introduction: </strong>Following traumatic injury, both the inflammatory and hemostatic systems are activated. Patients experience a systemic increase in circulating cytokines and coagulation leading to a greater risk of organ dysfunction. Post-trauma aeromedical evacuation exposes patients to hypobaria and potential hypoxia. We sought to assess the impact of hypobaria and hypoxic (H/H) on mortality, coagulation, and inflammation in a mouse model of polytrauma.</p><p><strong>Materials and methods: </strong>Eight- to 12-week-old male C57BL/6J mice were subjected to sham or polytrauma operation with the latter consisting of bowel ischemia via laparotomy and superior mesenteric artery (SMA) occlusion, gastrocnemius muscle crush, and tibia fracture. Sham mice were subjected to laparotomy only. Immediately post SMA reperfusion, animals were randomized to (1) 6 hours at sea level with normobaria and normoxia (N/N) conditions or (2) simulated aeromedical evacuation with H/H conditions. At 6 hours post SMA reperfusion, mice were subjected to general anesthesia, cardiac puncture blood draw, and bronchioalveolar lavage (BAL). Global coagulation was measured by rotational thromboelastometry (ROTEM), and plasma mediators were measured by enzyme-linked immunosorbent assay (ELISA) and Luminex. Extracellular vesicles (EVs) were isolated for treatment of mouse macrophages and naive mouse blood.</p><p><strong>Results: </strong>Compared to sham-operated mice, polytrauma mice under N/N conditions exhibited marked hypothermia (38.86 vs. 29.97 °C), systemic inflammation, and platelet activation as evidenced by an increase in plasma MIP-2, IL-6, and P-selectin, and developed alveolar inflammation with increases in BAL MIP-2 and IL-6 6 hours after traumatic injury. Extracellular vesicles isolated from polytrauma mice stimulated a greater release of both MIP-2 and IL-6 from mouse macrophages compared to EVs from sham mice. Polytrauma mice also demonstrated a decrease in platelets and an increase in maximum clot firmness (MCF) compared to sham. In polytrauma mice, H/H exposure significantly worsened hypothermia (N/N trauma vs. H/H trauma; 28.34 °C vs. 26.32 °C) and increased inflammation with elevated plasma levels of MIP-2 andIL-6, and higher MIP-2 in BAL samples. At higher concentrations, EVs isolated from H/H polytrauma mice stimulated a greater release of both MIP-2 and IL-6 from mouse macrophages compared to N/N polytrauma EVs. However, coagulation appeared to not be affected by the simulated aeromedical evacuation. Platelet count and MCF did not differ between H/H and N/N groups after polytrauma. Finally, polytrauma mice with H/H exposure had an increased mortality rate at 6 hours compared to those at sea level (N/N trauma vs. H/H trauma; 7.69% vs. 31.82%).</p><p><strong>Conclusions: </strong>The polytrauma model induces marked circulatory dysfunction, systemic inflammation, thrombocytopenia, and hypercoagulation in mice. Hypobaria and hypoxia exposure f
外伤性损伤后,炎症和止血系统都被激活。患者经历循环细胞因子和凝血系统的增加,导致器官功能障碍的风险更大。创伤后航空医疗后送使患者暴露于低血压和潜在的缺氧。我们试图评估低压和缺氧(H/H)对多发性创伤小鼠模型的死亡率、凝血和炎症的影响。材料与方法:8 ~ 12周龄雄性C57BL/6J小鼠进行假手术或多伤手术,后者包括剖腹肠缺血、肠系膜上动脉闭塞、腓肠肌挤压、胫骨骨折。假小鼠只接受剖腹手术。SMA再灌注后立即将动物随机分为(1)在海平面常压和常氧(N/N)条件下6小时或(2)在H/H条件下模拟航空医疗后送。SMA再灌注后6小时,小鼠进行全身麻醉、心脏穿刺抽血、细支气管肺泡灌洗(BAL)。采用旋转血栓弹性测量法(ROTEM)测量整体凝血,采用酶联免疫吸附试验(ELISA)和Luminex测量血浆介质。分离细胞外囊泡(EVs)用于处理小鼠巨噬细胞和小鼠幼稚血液。结果:与假手术小鼠相比,多创伤小鼠在N/N条件下表现出明显的低体温(38.86°C对29.97°C)、全身炎症和血小板活化(血浆MIP-2、IL-6和p -选择素增加),并在创伤后6小时出现肺泡炎症(BAL MIP-2和IL-6增加)。与假小鼠的EVs相比,从多发性创伤小鼠分离的细胞外囊泡刺激小鼠巨噬细胞释放更多的MIP-2和IL-6。与假手术相比,多发创伤小鼠也表现出血小板减少和最大凝块硬度(MCF)增加。在多创伤小鼠中,H/H暴露显著加重了低温(N/N创伤vs H/H创伤;28.34°C vs 26.32°C),炎症增加,血浆中MIP-2和il -6水平升高,BAL样本中MIP-2水平升高。在较高浓度下,与N/N多伤小鼠相比,从H/H多伤小鼠中分离的ev刺激小鼠巨噬细胞释放更多的MIP-2和IL-6。然而,凝血似乎不受模拟航空医疗后送的影响。多发性创伤后H/H组与N/N组血小板计数和MCF无显著差异。最后,与海平面下的小鼠相比,暴露于H/H的多伤小鼠在6小时的死亡率增加(N/N创伤vs H/H创伤;7.69% vs 31.82%)。结论:多发损伤模型可引起小鼠明显的循环功能障碍、全身炎症、血小板减少和高凝。低血压和低氧暴露进一步增加死亡率、循环功能障碍和多发外伤后的炎症。
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引用次数: 0
A Descriptive Analysis of Coronary Computed Tomography Angiography Results among Patients Presenting with Chest Pain in a Deployed Combat Environment. 在部署的战斗环境中表现为胸痛的患者的冠状动脉ct血管造影结果的描述性分析。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-06 DOI: 10.1093/milmed/usaf623
Joseph Salama, Jason A Unger, Summit R Kumar, Matthew Hayes, Caroline Murphy, Nicholas Orr, Michael April

Introduction: Chest pain is a frequent reason for evaluation at military treatment facilities in the deployed setting. Deployed persons are generally at low risk of coronary disease as the underlying cause for these symptoms; however, morbidity and mortality from acute coronary syndrome in an austere environment can be catastrophic. For theaters with access to computed tomography (CT), Coronary CT Angiography (CCTA) offers a diagnostic modality to effectively rule out this high-risk diagnosis in low to intermediate risk patients. The researchers present a descriptive analysis of CCTA use at a deployed Role 3 over a deployment rotation spanning 8 months.

Materials and methods: The researchers devised a CCTA protocol and delivered this diagnostic modality at a deployed Role 3 MTF. They included patients presenting with chest pain and stratified by the treating cleinician as intermediate risk given a history, electrocardiogram, age, cardiac risk factors, Troponin T, HEART score, and bedside echo when available. The CT scanner used by the researchers was a Siemens SOMATOM go, Top 128 slice, 70 cm bore, equipped with hardware to perform electrocardiography (ECG) gated studies and postprocessing. The researchers beta blocked patients to a target heart rate of 50-60 prior to each study, and administered a single 0.4 mg tab of sublingual nitroglycerin 4-7 minutes prior to starting angiography. They performed pre-angiography unenhanced CCTA to determine calcium score. Later, they performed ECG gated CCTA following intravenous (IV) contrast administration.

Results: The researchers performed four CCTA studies on symptomatic patients, each of whom also received a pre-angiogram CT calcium score. All four patients successfully completed the protocol. All four patients had a calcium score of 0. CCTA was low risk without any visible coronary disease for two patients and non-diagnostic for the remaining two patients. There was no major adverse event. One patient experienced a small volume IV access site infiltration at the end of the contrast bolus injection which did not limit that respective exam. The remaining patients did not experience any minor or major adverse events.

Conclusion: The initial data of this study is proof of concept that CCTA is feasible for assessing intermediate risk patients presenting with acute chest pain in the deployed setting, to rule our coronary pathology. The researchers' initial evaluation shows promise and suggests that this is a useful modality to continue to utilize and study in this environment.

简介:胸痛是军事治疗设施在部署设置评估的一个常见原因。作为这些症状的根本原因,被派遣人员患冠状动脉疾病的风险一般较低;然而,急性冠状动脉综合征的发病率和死亡率在严峻的环境中可能是灾难性的。对于可以使用计算机断层扫描(CT)的剧院,冠状动脉CT血管造影(CCTA)提供了一种诊断方式,可以有效地排除中低风险患者的这种高风险诊断。研究人员对部署角色3在8个月轮换期间的CCTA使用情况进行了描述性分析。材料和方法:研究人员设计了一种CCTA方案,并在部署的Role 3 MTF中提供了这种诊断模式。他们包括以胸痛为表现的患者,根据病史、心电图、年龄、心脏危险因素、肌钙蛋白T、心脏评分和床边回声(如有),由治疗临床医生分层为中度危险患者。研究人员使用的CT扫描仪是西门子SOMATOM go,顶部128层,70厘米孔径,配备硬件进行心电图(ECG)门控研究和后处理。在每次研究之前,研究人员将患者的β阻断到目标心率50-60,并在开始血管造影前4-7分钟给予0.4毫克的舌下硝酸甘油。他们进行血管造影前无增强CCTA测定钙评分。随后,他们在静脉注射造影剂后进行心电图门控CCTA。结果:研究人员对有症状的患者进行了四项CCTA研究,每个患者也接受了血管造影前CT钙评分。四名患者均成功完成了治疗方案。所有4例患者的钙评分均为0。2例患者CCTA为低风险,无明显冠状动脉病变,其余2例无诊断性。没有重大的不良事件。一名患者在造影剂注射结束时经历了小体积静脉注射部位浸润,这并没有限制各自的检查。其余患者没有发生任何轻微或严重的不良事件。结论:本研究的初步数据证明了CCTA在部署环境中评估急性胸痛的中危患者是可行的,以指导我们的冠状动脉病理。研究人员的初步评估显示出了希望,并表明这是一种有用的模式,可以在这种环境下继续利用和研究。
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引用次数: 0
Operation Gunpowder Leader Performance as a Predictor of Operation Bushmaster Leader Performance. 火药行动领导者绩效对大毒蛇行动领导者绩效的预测作用。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-06 DOI: 10.1093/milmed/usag004
Bryce Pierce, Erin S Barry, Leslie Vojta, Melissa Myers, Hannah Kleber, Cynthia Shen, Yen Lee
<p><strong>Introduction: </strong>Early leadership development is an increasing focus in both military and civilian undergraduate medical education, where physicians are expected to lead multidisciplinary teams and perform under complex, high-stakes conditions. Despite a growing number of leadership training programs, few studies have evaluated the longitudinal progression of leadership competencies across medical school using standardized, validated tools. The Uniformed Services University (USU) has implemented a longitudinal leadership curriculum grounded in the Leader-Follower (LF2) Framework, which includes 4 core elements: Character, Competence, Context, and Communication. This study aimed to determine whether leadership performance during a third-year immersive field practicum (Operation Gunpowder) correlates with and predicts subsequent performance in a fourth-year practicum (Operation Bushmaster) using the same standardized assessment approach.</p><p><strong>Materials and methods: </strong>This observational cohort study included 151 students from USU's class of 2025 who completed both military field practicums (MFP). Both MFPs assessed students using a validated 5-item leadership evaluation tool aligned with the LF2 framework. Each element was rated on a 4-point Likert scale. Pearson correlation coefficients were calculated to assess associations between MFP leadership scores. Best subset regression was used to identify which Gunpowder leadership elements best predicted Bushmaster performance. The study was approved by the USU Institutional Review Board (Protocol Number: KM83XV).</p><p><strong>Results: </strong>The total leadership score from Gunpowder was positively correlated with the total score from Bushmaster. Among individual elements, only Leadership Transcendent Skills (LTS) and Role-Specific Competence during Gunpowder showed positive correlations with their corresponding Bushmaster scores. LTS in Gunpowder was significantly correlated with all 5 leadership elements in Bushmaster, while Role-Specific Competence correlated with all Bushmaster elements except Communication. Regression analysis identified LTS as the strongest and most consistent predictor of Bushmaster performance across multiple domains, including Character, Communication, and LTS itself. In contrast, Role-Specific Competence from Gunpowder only predicted the same element in Bushmaster. The overall Gunpowder sum score was not a significant predictor of any individual Bushmaster element.</p><p><strong>Conclusions: </strong>This study demonstrates that specific leadership traits assessed early in medical school, particularly LTS, predict future leadership performance in operationally realistic environments. The cross-domain predictive power of LTS suggests it may serve as a transferable core skill analogous to Trait Emotional Intelligence (Trait EI), reinforcing its potential value in early leadership curricula. In contrast, Role-Specific Competence appeared to be c
简介:早期领导力发展在军事和民用本科医学教育中日益受到关注,医生被期望领导多学科团队并在复杂、高风险的条件下工作。尽管领导力培训项目越来越多,但很少有研究使用标准化的、经过验证的工具来评估领导能力在医学院的纵向发展。统一服务大学(USU)实施了一项基于领导者-追随者(LF2)框架的纵向领导力课程,其中包括4个核心要素:性格、能力、环境和沟通。本研究旨在利用相同的标准化评估方法,确定第三年沉浸式实地实习(火药行动)期间的领导绩效是否与第四年实习(大毒蛇行动)中的后续绩效相关并预测其绩效。材料和方法:本观察性队列研究包括151名USU 2025级学生,他们完成了军事实地实习(MFP)。两个mfp都使用与LF2框架一致的经过验证的5项领导力评估工具来评估学生。每个元素都以4分的李克特量表进行评分。计算Pearson相关系数来评估MFP领导得分之间的关联。使用最佳子集回归来确定哪些火药领导元素最能预测大毒蛇的表现。该研究由USU机构审查委员会批准(协议号:KM83XV)。结果:《火药》的领导能力总分与《大毒蛇》的领导能力总分呈显著正相关。在各要素中,只有领导力超越技能(LTS)和角色特定能力(Role-Specific Competence)与其对应的Bushmaster得分呈显著正相关。《火药》中的LTS与《Bushmaster》中的所有5个领导要素均显著相关,而角色特定能力与除《Communication》外的所有Bushmaster要素均显著相关。回归分析表明,LTS是在多个领域(包括性格、沟通和LTS本身)中最强和最一致的Bushmaster表现预测器。相比之下,来自火药的角色特定能力只预测了大毒蛇的相同元素。火药的总得分对任何一个大毒蛇元素都没有显著的预测作用。结论:本研究表明,在医学院早期评估的特定领导特质,特别是LTS,可以预测未来在实际操作环境中的领导表现。LTS的跨领域预测能力表明,它可以作为一种可转移的核心技能,类似于特质情商(Trait情商),从而增强了其在早期领导力课程中的潜在价值。相比之下,角色特定能力似乎受情境限制,在更广泛的预测影响方面受到限制。这项研究的一个关键优势是它在单个机构不断发展但始终如一的领导力课程中使用了标准化、纵向、非自我报告的评估数据。限制包括单一机构设计和缺乏研究生表现数据。未来的研究应该评估整个队列的可重复性,检查住院医师的长期预测价值,并探索民用培训项目的普遍性。
{"title":"Operation Gunpowder Leader Performance as a Predictor of Operation Bushmaster Leader Performance.","authors":"Bryce Pierce, Erin S Barry, Leslie Vojta, Melissa Myers, Hannah Kleber, Cynthia Shen, Yen Lee","doi":"10.1093/milmed/usag004","DOIUrl":"https://doi.org/10.1093/milmed/usag004","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Early leadership development is an increasing focus in both military and civilian undergraduate medical education, where physicians are expected to lead multidisciplinary teams and perform under complex, high-stakes conditions. Despite a growing number of leadership training programs, few studies have evaluated the longitudinal progression of leadership competencies across medical school using standardized, validated tools. The Uniformed Services University (USU) has implemented a longitudinal leadership curriculum grounded in the Leader-Follower (LF2) Framework, which includes 4 core elements: Character, Competence, Context, and Communication. This study aimed to determine whether leadership performance during a third-year immersive field practicum (Operation Gunpowder) correlates with and predicts subsequent performance in a fourth-year practicum (Operation Bushmaster) using the same standardized assessment approach.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;This observational cohort study included 151 students from USU's class of 2025 who completed both military field practicums (MFP). Both MFPs assessed students using a validated 5-item leadership evaluation tool aligned with the LF2 framework. Each element was rated on a 4-point Likert scale. Pearson correlation coefficients were calculated to assess associations between MFP leadership scores. Best subset regression was used to identify which Gunpowder leadership elements best predicted Bushmaster performance. The study was approved by the USU Institutional Review Board (Protocol Number: KM83XV).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The total leadership score from Gunpowder was positively correlated with the total score from Bushmaster. Among individual elements, only Leadership Transcendent Skills (LTS) and Role-Specific Competence during Gunpowder showed positive correlations with their corresponding Bushmaster scores. LTS in Gunpowder was significantly correlated with all 5 leadership elements in Bushmaster, while Role-Specific Competence correlated with all Bushmaster elements except Communication. Regression analysis identified LTS as the strongest and most consistent predictor of Bushmaster performance across multiple domains, including Character, Communication, and LTS itself. In contrast, Role-Specific Competence from Gunpowder only predicted the same element in Bushmaster. The overall Gunpowder sum score was not a significant predictor of any individual Bushmaster element.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study demonstrates that specific leadership traits assessed early in medical school, particularly LTS, predict future leadership performance in operationally realistic environments. The cross-domain predictive power of LTS suggests it may serve as a transferable core skill analogous to Trait Emotional Intelligence (Trait EI), reinforcing its potential value in early leadership curricula. In contrast, Role-Specific Competence appeared to be c","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Descriptive Epidemiology of Musculoskeletal Injuries Presenting to an Embedded Holistic Health and Fitness (H2F) Team in a United States Army Stryker Brigade, October 2021-September 2022. 2021年10月至2022年9月,美国陆军斯瑞克旅嵌入式整体健康和健身(H2F)团队对肌肉骨骼损伤的描述性流行病学研究
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-05 DOI: 10.1093/milmed/usaf645
Jacob A Naylor, Michele Jonsson Funk, Shabbar I Ranapurwala, Michelle Canham Chervak, Evan Mayo-Wilson, Mikala K Bruno, Christian V Olivarez, Stephen W Marshall

Introduction: In 2020, the U.S. Army began implementation of the Holistic Health and Fitness (H2F) system to reduce musculoskeletal injury (MSKI) rates and expedite rehabilitation after injury. The purpose of this study was to describe the rates and characteristics of incident MSKIs evaluated by H2F physical therapists (PTs) and athletic trainers (ATs) in a U.S. Army Stryker brigade combat team from October 2021 to September 2022.

Materials and methods: In this retrospective observational study, we used negative binomial models and the H2F injury tracker and Army administrative data to estimate MSKI incidence rates for the overall brigade and within strata of battalion, age, sex, rank, race, and ethnicity. We repeated these estimates when standardized to the overall brigade population by battalion, age, sex, and rank. We characterized distributions of time from injury to evaluation, limited duty days (i.e., time-loss), and activity at time of injury. This research was determined exempt by academic and military Institutional Review Boards.

Results: The embedded H2F PTs and ATs evaluated 2,140 incident MSKIs in the brigade (4,780 person-years) for an overall rate of 39.1 MSKIs per 1,000 person-months. Battalion rates ranged from 31.8 (field artillery) to 50.0 (infantry) and did not change substantially after standardization. Embedded H2F PTs and ATs evaluated 63% of MSKIs within 1 week of onset, managed 59% without assigning time-loss, and found 51% of MSKIs occurred during unit physical fitness training.

Conclusions: These findings are consistent with the a priori expectation that embedded providers and the H2F system expedited access to MSKI evaluation and treatment. A strength of this study was our ability to estimate MSKI incidence rates and characterize MSKI evaluated in the H2F environment using a novel injury tracker coupled with administrative data. A limitation is that because of data deidentification, we could not measure cumulative time-loss. This descriptive observational study will help inform the findings of subsequent research on the effect of H2F implementation on MSKI outcomes.

简介:2020年,美国陆军开始实施全面健康和健身(H2F)系统,以降低肌肉骨骼损伤(MSKI)率并加快损伤后的康复。本研究的目的是描述由H2F物理治疗师(PTs)和运动教练(ATs)在2021年10月至2022年9月期间在美国陆军Stryker旅战斗队评估的事件MSKIs的发生率和特征。材料和方法:在这项回顾性观察研究中,我们使用负二项模型、H2F伤害追踪器和陆军行政数据来估计整个旅以及营、年龄、性别、军衔、种族和民族各阶层的MSKI发病率。当按营、年龄、性别和军衔标准化到整个旅的人口时,我们重复了这些估计。我们描述了从受伤到评估的时间分布、有限的值班日(即时间损失)和受伤时的活动。这项研究被学术和军事机构审查委员会确定为豁免。结果:嵌入的H2F PTs和ATs评估了旅中2,140例mski事件(4,780人年),总发生率为每1,000人月39.1例mski。营率从31.8(野战炮兵)到50.0(步兵)不等,标准化后没有实质性变化。嵌入式H2F PTs和ATs在发病1周内评估了63%的mski,在没有分配时间损失的情况下管理了59%,并发现51%的mski发生在单位体能训练期间。结论:这些发现与先验预期一致,即嵌入式供应商和H2F系统加速了MSKI的评估和治疗。这项研究的优势在于,我们能够利用一种新型的损伤追踪器和管理数据,在H2F环境中评估MSKI的发病率和特征。一个限制是,由于数据去识别,我们无法测量累积的时间损失。这项描述性观察性研究将有助于为后续关于H2F实施对MSKI结果影响的研究结果提供信息。
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引用次数: 0
A Scoping Review on Military Airway Studies. 军事航空研究的范围综述。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-05 DOI: 10.1093/milmed/usag001
R Jimena Huaman, Michael D April, Julie A Rizzo, Matthew D Smith, Sylvain Cardin, Steven G Schauer

Introduction: Airway compromise is an urgent and life-threatening challenge that commonly occurs on the battlefield. Effective airway management on the battlefield is critical for reducing preventable deaths. This review summarizes the existing literature on airway management in the deployed combat setting.

Materials and methods: We conducted a scoping review using the PRISMA-ScR checklist. We used PubMed and Google Scholar to identify relevant literature from 2001 to 2025 which reflects the years for the Global War On Terrorism. Studies were eligible if they reported on airway interventions in the combat setting.

Results: There were 30 airway studies that met inclusion for this review. Of the studies included in this review, 3 were focused on endotracheal intubation (ETI), 3 were focused on cricothyrotomy, 1 was focused on supraglottic airways, and 23 evaluated more than 1 airway method. The studies included 4 prospective observational studies, and 25 retrospective observational studies. Overall, ETI was the most commonly reported airway procedure with the majority performed by medical officers in both the fixed and prehospital settings. Cricothyrotomy was the second most commonly reported with a relatively low incidence and high complication. Multiple studies highlighted gaps in skills training as well as technology as a complicating factors.

Conclusions: Effective airway management is critical for reducing preventable deaths on the battlefield. Endotracheal intubation is the most common advanced airway intervention, while cricothyrotomy and supraglottic airways are less common and show variable success. Ongoing gaps in training, documentation, and equipment access highlight the need for standardized airway protocols and improved training programs to improve battlefield survival among casualties requiring an advanced airway.

气道损伤是战场上经常发生的紧急和危及生命的挑战。战场上有效的气道管理对于减少可预防的死亡至关重要。本文综述了部署作战环境下气道管理的现有文献。材料和方法:我们使用PRISMA-ScR检查表进行了范围审查。我们使用PubMed和b谷歌Scholar来识别2001年至2025年的相关文献,这些文献反映了全球反恐战争的年份。如果研究报告了战斗环境中的气道干预,则该研究是合格的。结果:有30项气道研究符合纳入本综述。本综述纳入的研究中,3项研究集中于气管内插管(ETI), 3项研究集中于环甲环切开术,1项研究集中于声门上气道,23项研究评估了1种以上气道方法。研究包括4项前瞻性观察性研究和25项回顾性观察性研究。总的来说,ETI是最常见的气道手术,大多数由医务人员在固定和院前环境中进行。环甲环甲切开术是第二常见的报道,发病率相对较低,并发症较高。多项研究强调,技能培训和技术方面的差距是一个复杂的因素。结论:有效的气道管理对于减少战场上可预防的死亡至关重要。气管内插管是最常见的先进气道干预,而环甲环切开术和声门上气道不太常见,成功率参差不齐。在训练、文件和设备获取方面存在的差距突出了标准化气道协议和改进训练计划的必要性,以提高需要先进气道的伤亡人员的战场生存能力。
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引用次数: 0
A Triad of Hematologic Diseases in a Military Member Requiring Splenectomy Case Report. 军人三联性血液病需要脾切除术病例报告。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-03 DOI: 10.1093/milmed/usag017
Kevin D Anderson, Brianna L Middel, Austin J Klomp

Hereditary spherocytosis and sickle cell disease are two distinct hematologic diseases that affect the morphology of the red blood cell, causing implications related to splenic sequestration. Concurrent disease is very rare, with even fewer reported instances requiring surgical intervention. Furthermore, an individual with a third concomitant hematologic abnormality such as Factor VII deficiency, which degrades the normal clotting cascade, has not previously been reported. We describe an active-duty servicemember with known hereditary spherocytosis, sickle cell trait, and Factor VII deficiency who had recurrent worsening pain crises post-flight. The resulting hepatobiliary and splenic damage that ensued ultimately required splenectomy. These diseases in combination further enhance risks associated with splenic damage and intra-operative bleeding, with special consideration for intra-operative risk management and long-term sequala from end-organ damage. The military population exacerbates these conditions where physical exertion, high-altitude travel, and rapid geographic reassignment are considered the norm. This case of a servicemember with a unique disease triad managed successfully with surgical correction underscores the importance of individualized care planning and consideration of duty readiness.

遗传性球形红细胞增多症和镰状细胞病是两种不同的血液病,它们影响红细胞的形态,引起与脾隔离相关的影响。并发疾病是非常罕见的,甚至更少的报道的情况下,需要手术干预。此外,个体与第三伴随血液学异常,如因子7缺乏,降低正常的凝血级联,以前没有报道过。我们描述了一名现役军人与已知的遗传性球形红细胞增多症,镰状细胞特征,和因子VII缺乏谁有复发性恶化的疼痛危机飞行后。由此导致的肝胆和脾损伤最终需要脾切除术。这些疾病的合并进一步增加了脾损伤和术中出血的相关风险,特别要考虑术中风险管理和终末器官损伤的长期后遗症。由于体力消耗、高海拔旅行和快速的地理重新分配被认为是常态,军事人口加剧了这些情况。本病例是一名患有独特疾病的军人,通过手术矫正成功地管理了三位一体,强调了个性化护理计划和考虑值班准备的重要性。
{"title":"A Triad of Hematologic Diseases in a Military Member Requiring Splenectomy Case Report.","authors":"Kevin D Anderson, Brianna L Middel, Austin J Klomp","doi":"10.1093/milmed/usag017","DOIUrl":"https://doi.org/10.1093/milmed/usag017","url":null,"abstract":"<p><p>Hereditary spherocytosis and sickle cell disease are two distinct hematologic diseases that affect the morphology of the red blood cell, causing implications related to splenic sequestration. Concurrent disease is very rare, with even fewer reported instances requiring surgical intervention. Furthermore, an individual with a third concomitant hematologic abnormality such as Factor VII deficiency, which degrades the normal clotting cascade, has not previously been reported. We describe an active-duty servicemember with known hereditary spherocytosis, sickle cell trait, and Factor VII deficiency who had recurrent worsening pain crises post-flight. The resulting hepatobiliary and splenic damage that ensued ultimately required splenectomy. These diseases in combination further enhance risks associated with splenic damage and intra-operative bleeding, with special consideration for intra-operative risk management and long-term sequala from end-organ damage. The military population exacerbates these conditions where physical exertion, high-altitude travel, and rapid geographic reassignment are considered the norm. This case of a servicemember with a unique disease triad managed successfully with surgical correction underscores the importance of individualized care planning and consideration of duty readiness.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pilonidal Disease: A Recent Decade of the Disease among Active Duty United States Military Service Members. 毛线虫病:最近十年美国现役军人中的疾病。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-03 DOI: 10.1093/milmed/usag015
Dylan M Griffiths, Meg I Robinson, Amber L Dougherty, Laura S Kraemer, Andrew J Macgregor, James D Wallace, Diego A Vicente, Christian S Mcevoy

Introduction: Sacrococcygeal pilonidal disease (PD) is a common surgical problem in the U.S. Military. Despite recent advancements, treatment strategies remain heterogenous and incompletely described, particularly among the active duty component in the Military Health System (MHS). This study's objectives were to identify the burden of PD and describe current healthcare utilization and treatment patterns in the MHS during a recent 10-year study period.

Materials and methods: The study population included all active duty U.S. service members with at least one PD diagnosis in the MHS Data Repository between January 1, 2013, and December 31, 2022. For each patient, the first PD diagnosis during the study period was the incident case, and a subsequent case was defined as a second PD diagnosis >30 days after the first and categorized as recurrent (procedure performed at incident encounter) or persistent (no procedure performed at incident encounter). Procedures were identified by Current Procedural Terminology codes.

Results: During the study period, 25,039 active duty service members were diagnosed with an incident case of PD. The study population was mostly male, less than 30 years old, enlisted, and in the Army or Navy. The overall incidence rate was 1.7 per 1,000 person-years. Prevalence of recurrence was 44.6% (2,494 of 5,598) and persistence was 50.1% (9,731 of 19,441). Overall, there were 115,387 medical encounters with a PD diagnosis during the study period, and service members in the top 25% for healthcare utilization had ≥11 encounters with a PD diagnosis.

Conclusions: Pilonidal disease imposes a significant burden on the MHS and is a threat to overall force medical readiness. Treatment strategies remain heterogeneous, and prospective studies are needed to refine clinical guidelines.

简介:骶尾骨毛突病(PD)是美国军队常见的外科问题。尽管最近取得了进展,但治疗策略仍然是异质的,描述不完整,特别是在军事卫生系统(MHS)的现役成分中。本研究的目的是确定PD的负担,并描述MHS在最近10年的研究期间当前的医疗保健利用和治疗模式。材料和方法:研究人群包括2013年1月1日至2022年12月31日期间在MHS数据存储库中至少有一次PD诊断的所有美国现役军人。对于每个患者,在研究期间的第一次PD诊断为偶发病例,随后的病例被定义为第一次PD诊断后30天的第二次PD诊断,并被分类为复发性(在偶发事件中进行手术)或持续性(在偶发事件中未进行手术)。程序由现行程序术语代码确定。结果:在研究期间,25,039名现役军人被诊断为PD事件病例。研究人群主要是男性,年龄在30岁以下,在陆军或海军服役。总发病率为每1000人年1.7例。复发率为44.6%(5598例中2494例),持续性为50.1%(19441例中9731例)。总体而言,在研究期间有115,387次PD诊断的医疗就诊,医疗保健利用率最高的25%的服务人员有≥11次PD诊断。结论:毛鞘疾病给MHS带来了巨大的负担,并威胁到整体部队的医疗准备。治疗策略仍然不同,需要前瞻性研究来完善临床指南。
{"title":"Pilonidal Disease: A Recent Decade of the Disease among Active Duty United States Military Service Members.","authors":"Dylan M Griffiths, Meg I Robinson, Amber L Dougherty, Laura S Kraemer, Andrew J Macgregor, James D Wallace, Diego A Vicente, Christian S Mcevoy","doi":"10.1093/milmed/usag015","DOIUrl":"https://doi.org/10.1093/milmed/usag015","url":null,"abstract":"<p><strong>Introduction: </strong>Sacrococcygeal pilonidal disease (PD) is a common surgical problem in the U.S. Military. Despite recent advancements, treatment strategies remain heterogenous and incompletely described, particularly among the active duty component in the Military Health System (MHS). This study's objectives were to identify the burden of PD and describe current healthcare utilization and treatment patterns in the MHS during a recent 10-year study period.</p><p><strong>Materials and methods: </strong>The study population included all active duty U.S. service members with at least one PD diagnosis in the MHS Data Repository between January 1, 2013, and December 31, 2022. For each patient, the first PD diagnosis during the study period was the incident case, and a subsequent case was defined as a second PD diagnosis >30 days after the first and categorized as recurrent (procedure performed at incident encounter) or persistent (no procedure performed at incident encounter). Procedures were identified by Current Procedural Terminology codes.</p><p><strong>Results: </strong>During the study period, 25,039 active duty service members were diagnosed with an incident case of PD. The study population was mostly male, less than 30 years old, enlisted, and in the Army or Navy. The overall incidence rate was 1.7 per 1,000 person-years. Prevalence of recurrence was 44.6% (2,494 of 5,598) and persistence was 50.1% (9,731 of 19,441). Overall, there were 115,387 medical encounters with a PD diagnosis during the study period, and service members in the top 25% for healthcare utilization had ≥11 encounters with a PD diagnosis.</p><p><strong>Conclusions: </strong>Pilonidal disease imposes a significant burden on the MHS and is a threat to overall force medical readiness. Treatment strategies remain heterogeneous, and prospective studies are needed to refine clinical guidelines.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intended and Unintended Pregnancies: Social Determinants and Pregnancy Mental Health from a Decade of Military Research. 有意怀孕和意外怀孕:十年军事研究中的社会决定因素和怀孕心理健康。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-02-02 DOI: 10.1093/milmed/usaf648
Monica A Lutgendorf, Katherine C Walker-Rodriquez, Tony T Yuan, Wenyaw C Chan, Karen L Weis

Introduction: Unintended pregnancy is linked to maternal depression, substance use, late prenatal care, low birthweight, and preterm birth. Our objective was to examine the incidence of unintended pregnancies in the military, the effects on maternal mental health and the effects of Social Determinants of Health (SDOH).

Materials and methods: This was an institutional research board-approved secondary analysis of two independent military datasets of pregnant individuals participating in two prospective clinical trials of a pregnancy mentorship program, collected 2012-2017 (n = 246) and 2018-2022 (n = 1,523), and compared to assess relationships of SDOH and maternal mental health measures for those with and without intended pregnancies.

Results: The rate of unintended pregnancy reported by participants was higher, 42.8% in 2012-2017 compared to 34.4% in 2018-2022. The rates of unintended pregnancy in both periods were lower than the national average and was lower in the second study period compared to the first. There were significantly higher scores for both anxiety and depression for those with unintended pregnancies, regardless of the sample. Over the same periods, the perception of support (as measured by the social support index) was higher in 2012-2017 compared to 2018-2022. Although the measures do not significantly differ by age, military branch, or rank, there was a significant relationship between the level of education and a lower rate of unintended pregnancy.

Conclusion: Exploration of Military Health System pregnancy data is important as it provides one of the best pictures of family and force readiness. The recent issue of unintended pregnancy and the increasing incidence of depression and anxiety, with lowered perceived support have long-term implications for the overall health and well-being of the U.S. military force, which demands continued investigation.

意外怀孕与母亲抑郁、药物使用、产前护理晚、低出生体重和早产有关。我们的目的是调查军队中意外怀孕的发生率、对产妇心理健康的影响以及健康的社会决定因素(SDOH)的影响。材料和方法:这是一项机构研究委员会批准的二次分析,收集了2012-2017年(n = 246)和2018-2022年(n = 1523)参加怀孕指导计划的两项前瞻性临床试验的孕妇的两个独立军事数据集,并比较了SDOH与有意怀孕和非有意怀孕的孕产妇心理健康措施的关系。结果:参与者报告的意外怀孕率更高,2012-2017年为42.8%,而2018-2022年为34.4%。这两个时期的意外怀孕率都低于全国平均水平,第二个研究期间的意外怀孕率比第一个研究期间的意外怀孕率低。无论样本是什么,意外怀孕的女性在焦虑和抑郁方面的得分都明显更高。在同一时期,与2018-2022年相比,2012-2017年对支持的感知(以社会支持指数衡量)更高。虽然这些措施在年龄、军种或军衔方面没有显著差异,但教育水平与较低的意外怀孕率之间存在显著关系。结论:探索军队卫生系统妊娠数据是重要的,因为它提供了家庭和部队准备的最佳图片之一。最近意外怀孕、抑郁和焦虑发生率的增加,以及感知支持度的降低,对美国军队的整体健康和福祉产生了长期影响,这需要继续调查。
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引用次数: 0
A Critical Look at the Challenges of Conducting de-Identified Military Surveys. 对开展去身份化军事调查的挑战的批判性审视。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-31 DOI: 10.1093/milmed/usaf633
Maegan M Paxton Willing, Jaime Rodden, Ariana R Bazzi, Sebastian Preilipper, Linda Thompson

Survey research has long been a cornerstone of behavioral health and medical research. With the growth of Internet-based survey platforms, accelerated by the COVID-19 pandemic, conducting surveys completely online has become the standard. Online surveys provide the field with a fast, cost-effective method for gaining insights into relationships among health variables or in obtaining preliminary data to inform larger-scale studies. Additionally, online surveys enable researchers to recruit from a larger geographical area, thus increasing the generalizability of findings and, importantly, allowing participants to complete study activities completely de-identified. Although participating anonymously can increase one's comfort with disclosing sensitive or stigmatizing information, this can pose significant challenges to ensuring the legitimacy of participants' eligibility. This may be particularly true when compensation is available, increasing the likelihood of a prospective participant falsely reporting characteristics such as current or former military service. The following commentary provides an overview of the current landscape for researchers conducting military-related research via online surveys, with a specific emphasis on challenges in ensuring participants have a military background. In support of this, we present several real-world challenges for conducting de-identified online surveys, such as difficulties ensuring participants have a military background and preventing the use of "bots." Additionally, the evolving challenge of artificial intelligence is discussed in the context of its impact on knowledge-based screening methods such as the Military Screener Questionnaire. Alternative approaches, such as compensated screening surveys, are presented. Surveys will continue to be an important tool for advancing military medical research; however, researchers must discuss findings within the context of the inherent limitations of the methodology. The field should carefully monitor the evolving challenges to conducting online surveys.

长期以来,调查研究一直是行为健康和医学研究的基石。随着互联网调查平台的发展,在新冠肺炎疫情的加速下,完全在线进行调查已成为标准。在线调查为该领域提供了一种快速、具有成本效益的方法,可以深入了解健康变量之间的关系,或获得初步数据,为更大规模的研究提供信息。此外,在线调查使研究人员能够从更大的地理区域招募,从而增加了研究结果的普遍性,重要的是,允许参与者完全去识别地完成研究活动。尽管匿名参与可以增加人们对披露敏感或污名化信息的舒适感,但这可能对确保参与者资格的合法性构成重大挑战。在有补偿的情况下尤其如此,这增加了潜在参与者谎报当前或以前服兵役等特征的可能性。以下评论概述了通过在线调查进行军事相关研究的研究人员的现状,特别强调了确保参与者具有军事背景方面的挑战。为了支持这一点,我们提出了进行去身份化在线调查的几个现实挑战,例如确保参与者具有军事背景和防止使用“机器人”的困难。此外,在其对基于知识的筛选方法(如军事筛选问卷)的影响的背景下讨论了人工智能不断发展的挑战。提出了替代方法,如有偿筛选调查。调查将继续是推进军事医学研究的重要工具;然而,研究人员必须在方法论固有局限性的背景下讨论研究结果。该领域应仔细监测开展在线调查的不断变化的挑战。
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引用次数: 0
Military Exposures Research: A State-of-the-Art Review. 军事暴露研究:最新进展综述。
IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-01-31 DOI: 10.1093/milmed/usaf647
Rachel T Wright, Jacob B Lindheimer, Israel C Christie, Jaraad Ramkissoon, Shaili Bhavsar, Rosalinda Desrochers, Walter W Frauman, Drew A Helmer
<p><strong>Introduction: </strong>Military personnel encounter a wide range of environmental and occupational exposures during their service such as burn pit smoke, chemical warfare agents, depleted uranium, jet fuel, radiation, and pesticides. The field of military exposures research seeks to better understand the nature of these exposures and their effects on Veteran and service member health. This state-of-the-art review assesses the breadth and depth of published military exposures research so that stakeholders can identify trends and gaps in this growing field.</p><p><strong>Materials and methods: </strong>An evidence mapping approach was used to perform a literature review of military exposures research published from 1962 to 2024. The search strategy was developed around exposed cohorts: groups of military personnel with a shared potential for exposure to toxic agents. Publications were included if they directly addressed exposures or related health outcomes in military cohorts. Publications were then further categorized by the type of research, and the results were analyzed to build a map of the current military exposures research landscape.</p><p><strong>Results: </strong>Thirty-six exposed cohorts were identified in the literature which were then grouped based on the nature of the exposure event: Wars and Operations (4 cohorts), Occupational Exposures (5), Combat and Combat Training (2), Across Military (2), Ship Exposures (2), Defense Testing (2), Base/Garrison Exposures (9), Toxic Substance Clean-Up and Disposal (5), and Isolated Exposure Events (5). The search identified 2,321 publications that fit the review inclusion criteria. The exposed cohort with the highest number of publications was Gulf War (940, 40.5% of all publications) followed by Vietnam War (277, 11.9%), Post-9/11 Operations in Iraq and Afghanistan (191, 8.2%), Aircraft Mechanics and Ground Support (176, 7.6%), and Munition Emissions and Embedded Fragments (164, 7.1%). Each remaining cohort individually represented < 4% of the literature. Six cohorts appeared only in non-peer-reviewed reports. The type of research best represented was Epidemiology (34.0%) followed by Animal and In Vitro Models (18.8%), Sequelae and Management (17.1%), Reviews and Meta-Analyses (11.7%), Exposure Assessment (9.5%), Toxic Agent Sampling and Analysis (4.3%), and publications from the National Academy of Sciences, Engineering, and Medicine (4.6%). The volume of military exposures research has increased steadily since the early public reports of Gulf War Illness in 1994, with 50% of articles being published after 2008.</p><p><strong>Conclusion: </strong>Military exposures research published since 1962 has focused on cohorts from large, high-profile deployments, particularly the Gulf War. Underrepresented cohorts with potential exposures on bases or from military occupations present opportunities for future research. The lack of meaningful exposure assessment data that has been published also
简介:军事人员在服役期间会遇到各种各样的环境和职业暴露,如燃烧坑烟雾、化学战剂、贫铀、喷气燃料、辐射和农药。军事暴露研究领域旨在更好地了解这些暴露的性质及其对退伍军人和服务人员健康的影响。这项最新的审查评估了已发表的军事暴露研究的广度和深度,以便利益攸关方能够确定这一不断发展的领域的趋势和差距。材料和方法:采用证据映射方法对1962年至2024年发表的军事暴露研究进行文献综述。搜索策略是围绕暴露队列制定的:暴露于有毒物质的共同潜力的军事人员群体。如果出版物直接涉及军人群体的接触或相关健康结果,则列入其中。然后根据研究类型对出版物进行进一步分类,并对结果进行分析,以构建当前军事暴露研究景观的地图。结果:在文献中确定了36个暴露队列,然后根据暴露事件的性质进行分组:战争和行动(4个队列),职业暴露(5个),战斗和战斗训练(2个),跨军事(2个),船舶暴露(2个),防御测试(2个),基地/驻军暴露(9个),有毒物质清理和处置(5个)和孤立暴露事件(5个)。检索确定了2321篇符合综述纳入标准的出版物。发表数量最多的暴露队列是海湾战争(940,占所有出版物的40.5%),其次是越南战争(277,占11.9%),伊拉克和阿富汗的9/11后行动(191,占8.2%),飞机机械和地面支援(176,占7.6%),弹药排放和嵌入碎片(164,占7.1%)。每个剩余队列单独代表< 4%的文献。六个队列只出现在非同行评议的报告中。最具代表性的研究类型是流行病学(34.0%),其次是动物和体外模型(18.8%)、后遗症和管理(17.1%)、综述和荟萃分析(11.7%)、暴露评估(9.5%)、有毒物质抽样和分析(4.3%),以及来自美国国家科学院、工程和医学院的出版物(4.6%)。自1994年海湾战争疾病的早期公开报告以来,军事暴露研究的数量稳步增加,其中50%的文章是在2008年之后发表的。结论:自1962年以来发表的军事暴露研究主要集中在大规模,高调部署的队列,特别是海湾战争。在基地或军事职业中有潜在暴露的未充分代表的队列为未来的研究提供了机会。缺乏已发表的有意义的暴露评估数据也指出了进一步研究的机会,以具体改善暴露数据的收集和可及性。这项工作应该把重点放在研究可以直接影响退伍军人获得福利和暴露知情护理的群体上。
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Military Medicine
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