{"title":"Letter to the Editor: \"Testing for Sexually Transmitted Infections in Symptomatic Male Military Trainees\" by Malone et al.","authors":"Pierre-Louis Conan, France Charton, Cécile Ficko","doi":"10.1093/milmed/usag018","DOIUrl":"https://doi.org/10.1093/milmed/usag018","url":null,"abstract":"","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Military families face unique stressors, including prolonged separations due to deployments, frequent relocations, and parental injury that can contribute to increased rates of mental, emotional, behavioral, and developmental (MEBD) health concerns among military-connected youth. Although military children have access to universal health insurance coverage through TRICARE and access to primary care at military treatment facilities (MTFs) or through civilian network providers, military-connected children and adolescents face challenges accessing behavioral and developmental health care services. This study examines the experiences of military-connected parents navigating health care for their children with MEDB health care needs.
Materials and methods: This study utilized a qualitative research design with focus groups. Recruitment occurred via partners from the DOD Child Collaboratory, through email, flyers, and social media. Virtual focus groups were audio recorded and transcribed. Data analysis followed an inductive coding approach. The Institutional Review Board at the Uniformed Services University approved this study.
Results: Six, 1-hour virtual focus groups were completed with 18 participants. Four themes emerged as relevant to the experiences of participants (1) Military Life Circumstances: shape every step of military-connected children's MEDB health care journeys, (2) Barriers to Accessing MEDB Health Care: structural/systemic barriers and relational/perceptual barriers present challenges to accessing quality care, (3) The Diagnostic Journey: logistical pressures of military life and health care availability can delay diagnosis, (4) Facilitators to MEDB Care: the utility of formal military supports and providers with military cultural competence can improve MEDB health care access and quality.
Conclusions: Our data underscores the multifaceted journey of military families navigating MEDB health care and highlights the coexistence of dual concepts of readiness in military culture, ideal and real. These findings highlight opportunities to improve care coordination, streamline transitions, and enhance collaboration among support systems for military families managing MEDB health care needs. Addressing access to care challenges is critical to upholding the health of military children and families and achieving ideal readiness of the U.S. Military.
{"title":"Exploring Health Care Experiences of Military-Connected Parents of Children With Mental, Emotional, Developmental, and Behavioral Health Care Needs.","authors":"Colleen Runnion, Shanna Smith, Jessica Luckhardt, Kaitlin M Burke, Gabby L'Esperance, Binny Chokshi","doi":"10.1093/milmed/usaf638","DOIUrl":"https://doi.org/10.1093/milmed/usaf638","url":null,"abstract":"<p><strong>Introduction: </strong>Military families face unique stressors, including prolonged separations due to deployments, frequent relocations, and parental injury that can contribute to increased rates of mental, emotional, behavioral, and developmental (MEBD) health concerns among military-connected youth. Although military children have access to universal health insurance coverage through TRICARE and access to primary care at military treatment facilities (MTFs) or through civilian network providers, military-connected children and adolescents face challenges accessing behavioral and developmental health care services. This study examines the experiences of military-connected parents navigating health care for their children with MEDB health care needs.</p><p><strong>Materials and methods: </strong>This study utilized a qualitative research design with focus groups. Recruitment occurred via partners from the DOD Child Collaboratory, through email, flyers, and social media. Virtual focus groups were audio recorded and transcribed. Data analysis followed an inductive coding approach. The Institutional Review Board at the Uniformed Services University approved this study.</p><p><strong>Results: </strong>Six, 1-hour virtual focus groups were completed with 18 participants. Four themes emerged as relevant to the experiences of participants (1) Military Life Circumstances: shape every step of military-connected children's MEDB health care journeys, (2) Barriers to Accessing MEDB Health Care: structural/systemic barriers and relational/perceptual barriers present challenges to accessing quality care, (3) The Diagnostic Journey: logistical pressures of military life and health care availability can delay diagnosis, (4) Facilitators to MEDB Care: the utility of formal military supports and providers with military cultural competence can improve MEDB health care access and quality.</p><p><strong>Conclusions: </strong>Our data underscores the multifaceted journey of military families navigating MEDB health care and highlights the coexistence of dual concepts of readiness in military culture, ideal and real. These findings highlight opportunities to improve care coordination, streamline transitions, and enhance collaboration among support systems for military families managing MEDB health care needs. Addressing access to care challenges is critical to upholding the health of military children and families and achieving ideal readiness of the U.S. Military.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chelsea Cherenfant, Derek Licina, Logan Williams, Ian Scott, Jennifer Gurney, Teresa Duquette-Frame, Dallas Burelison, Rachel Brill
<p><strong>Introduction: </strong>The Department of Defense (DoD) has greatly reduced combatant morbidity and mortality in the last twenty years. Nevertheless, current distance, environment, and workforce challenges threaten these gains. Moreover, existing models predict current trauma system capacity is insufficient for large-scale combat operations. One potential solution is a globally integrated trauma system. This review sought to examine global research and policy on civilian and military trauma systems to identify necessary components for a DoD globally integrated trauma system (GTS).</p><p><strong>Materials and methods: </strong>This critical interpretive synthesis identified global theory, practice, and policy within trauma care to develop a framework for a DoD GTS. The World Health Organization's Building Blocks of Health served as the literature review conceptual framework, supplemented with core areas of trauma identified by the research team and other experts. Broad, browser-based searches were performed to identify global variations in trauma care terminology and locate national policy documents. Once key terms were established, more stringent searches were performed using the PubMed, Scopus, ProQuest, and EBSCOhost databases. A total of 2,791 results were screened, and 47 sources met the inclusion criteria. Data extraction composed of closed- and open-ended questions was performed by two independent researchers. The responses were compiled into one response to conduct descriptive statistics and define essential components for a DoD GTS.</p><p><strong>Results: </strong>Although the United States was the most frequently featured nation in publications, the U.S. Indo-Asia Pacific Command region had the largest representation. Governance and service delivery were the most cited building blocks of health. Protocols/guidelines and trauma centers were the most frequently cited core areas of trauma, followed by education/training, prehospital care, and data collection/registries. The emerging DRIVE (Domains of Responsibility, Influence, Values, and Execution) framework consists of four domains: trauma system responsibilities; trauma system levers; management, implementation, and operation; and qualities and values. Responsibilities could be subdivided into care delivery, trauma registries, injury prevention and safety promotion, political advocacy, and research and innovation.</p><p><strong>Conclusions: </strong>A GTS is an innovative strategy to address the risk to mission and force generated by existing DoD trauma system capacity shortfall. If developed appropriately across the four domains identified in this study, the system can enable the DoD to strengthen relationships with ally and partner nations, promote knowledge sharing, and improve global health outcomes. This study benefited from coalescing findings from 24 years of publications. However, the broad timeframe may have resulted in the inclusion of outdated information. Moreover,
{"title":"Defining Components of a DoD Globally Integrated Trauma System: A Global Review of Evidence, Policy, and Practice.","authors":"Chelsea Cherenfant, Derek Licina, Logan Williams, Ian Scott, Jennifer Gurney, Teresa Duquette-Frame, Dallas Burelison, Rachel Brill","doi":"10.1093/milmed/usaf616","DOIUrl":"https://doi.org/10.1093/milmed/usaf616","url":null,"abstract":"<p><strong>Introduction: </strong>The Department of Defense (DoD) has greatly reduced combatant morbidity and mortality in the last twenty years. Nevertheless, current distance, environment, and workforce challenges threaten these gains. Moreover, existing models predict current trauma system capacity is insufficient for large-scale combat operations. One potential solution is a globally integrated trauma system. This review sought to examine global research and policy on civilian and military trauma systems to identify necessary components for a DoD globally integrated trauma system (GTS).</p><p><strong>Materials and methods: </strong>This critical interpretive synthesis identified global theory, practice, and policy within trauma care to develop a framework for a DoD GTS. The World Health Organization's Building Blocks of Health served as the literature review conceptual framework, supplemented with core areas of trauma identified by the research team and other experts. Broad, browser-based searches were performed to identify global variations in trauma care terminology and locate national policy documents. Once key terms were established, more stringent searches were performed using the PubMed, Scopus, ProQuest, and EBSCOhost databases. A total of 2,791 results were screened, and 47 sources met the inclusion criteria. Data extraction composed of closed- and open-ended questions was performed by two independent researchers. The responses were compiled into one response to conduct descriptive statistics and define essential components for a DoD GTS.</p><p><strong>Results: </strong>Although the United States was the most frequently featured nation in publications, the U.S. Indo-Asia Pacific Command region had the largest representation. Governance and service delivery were the most cited building blocks of health. Protocols/guidelines and trauma centers were the most frequently cited core areas of trauma, followed by education/training, prehospital care, and data collection/registries. The emerging DRIVE (Domains of Responsibility, Influence, Values, and Execution) framework consists of four domains: trauma system responsibilities; trauma system levers; management, implementation, and operation; and qualities and values. Responsibilities could be subdivided into care delivery, trauma registries, injury prevention and safety promotion, political advocacy, and research and innovation.</p><p><strong>Conclusions: </strong>A GTS is an innovative strategy to address the risk to mission and force generated by existing DoD trauma system capacity shortfall. If developed appropriately across the four domains identified in this study, the system can enable the DoD to strengthen relationships with ally and partner nations, promote knowledge sharing, and improve global health outcomes. This study benefited from coalescing findings from 24 years of publications. However, the broad timeframe may have resulted in the inclusion of outdated information. Moreover, ","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard J Strilka, Joshua L Fiechter, Kent C Etherton, Nicole Leib, Lane L Frasier, Katelyn Kay, Joshua Burkhardt, Maia P Smith, Christopher B Horn, Valerie G Sams, Mark Cheney, William T Davis
<p><strong>Background: </strong>As the U.S. Armed Forces shift from counterterrorism operations to peer conflict, preparing Critical Care Air Transport (CCAT) teams for high-volume patient movement is imperative. Quantifying baseline CCAT task load and its impact on team performance is essential for guiding future research aimed at mitigating task saturation during the complex transport missions anticipated in peer conflict scenarios.</p><p><strong>Materials and methods: </strong>Individual provider task load and team performance were evaluated during a high-fidelity simulation conducted as part of the CCAT-Advanced Course. The 55-minute scenario involved the simultaneous care of 2 critically ill patients and was designed to impose a mild-to-moderate task load for mechanical ventilation management and a moderate-to-high task load for medication infusion management. Immediately following the simulation, participants completed the unweighted National Aeronautics and Space Administration Task Load Index (NASA-TLX). Team non-technical performance was assessed using the Team Emergency Assessment Measure (TEAM) instrument. Rather than aggregating NASA-TLX and TEAM subscale scores through arithmetic means (e.g., sums or averages), we applied multilevel Bayesian modeling. Specifically, we implemented a multivariate cumulative logit model-appropriate for ordinal Likert-scale data-that jointly modeled NASA-TLX and TEAM subscale responses. The model accounted for provider type as a predictor of task load (NASA-TLX) and nested observations within teams.</p><p><strong>Results: </strong>Data from 44 CCAT teams were analyzed. Across the cohort, the NASA-TLX dimensions with the highest estimated scores were Effort (13.4, IQR = [8.12, 17.14]), Mental Demand (13.4, IQR = [8.72, 17.1]), and Temporal Demand (11.6, IQR = [6.71, 15.2]), while Frustration (7.94), Performance (5.63), and Physical Demand (5.29) were lower. This pattern-elevated cognitive and temporal demands with lower physical and emotional strain-was consistent across provider types. Among physicians (MDs), there was a significant negative correlation between individual task load (total NASA-TLX score) and team performance (total TEAM score), with Spearman's rank correlation coefficient ρ = -0.23 (95% credible interval = [-0.36 to -0.09]). In contrast, correlations for respiratory therapists (RTs) and registered nurses (RNs) were not statistically reliable, with ρ = -0.07 (95% CI = [-0.21 to 0.07]) and ρ = -0.02 (95% CI = [-0.16 to 0.13]), respectively. For MDs, higher levels of Frustration, Mental Demand, Temporal Demand, and Effort, along with lower self-rated Performance, were significantly associated with lower TEAM scores. No comparable associations were observed for RNs or RTs. Finally, all MD-RN NASA-TLX dimension pairs were significantly correlated, ρ between 0.31 and 0.44; and essentially no correlations were found between the RN-RT or MD-RT comparisons.</p><p><strong>Conclusions: </strong>We
{"title":"Task Load Negatively Affects Critical Care Air Transport Team Performance in Simulation.","authors":"Richard J Strilka, Joshua L Fiechter, Kent C Etherton, Nicole Leib, Lane L Frasier, Katelyn Kay, Joshua Burkhardt, Maia P Smith, Christopher B Horn, Valerie G Sams, Mark Cheney, William T Davis","doi":"10.1093/milmed/usag020","DOIUrl":"https://doi.org/10.1093/milmed/usag020","url":null,"abstract":"<p><strong>Background: </strong>As the U.S. Armed Forces shift from counterterrorism operations to peer conflict, preparing Critical Care Air Transport (CCAT) teams for high-volume patient movement is imperative. Quantifying baseline CCAT task load and its impact on team performance is essential for guiding future research aimed at mitigating task saturation during the complex transport missions anticipated in peer conflict scenarios.</p><p><strong>Materials and methods: </strong>Individual provider task load and team performance were evaluated during a high-fidelity simulation conducted as part of the CCAT-Advanced Course. The 55-minute scenario involved the simultaneous care of 2 critically ill patients and was designed to impose a mild-to-moderate task load for mechanical ventilation management and a moderate-to-high task load for medication infusion management. Immediately following the simulation, participants completed the unweighted National Aeronautics and Space Administration Task Load Index (NASA-TLX). Team non-technical performance was assessed using the Team Emergency Assessment Measure (TEAM) instrument. Rather than aggregating NASA-TLX and TEAM subscale scores through arithmetic means (e.g., sums or averages), we applied multilevel Bayesian modeling. Specifically, we implemented a multivariate cumulative logit model-appropriate for ordinal Likert-scale data-that jointly modeled NASA-TLX and TEAM subscale responses. The model accounted for provider type as a predictor of task load (NASA-TLX) and nested observations within teams.</p><p><strong>Results: </strong>Data from 44 CCAT teams were analyzed. Across the cohort, the NASA-TLX dimensions with the highest estimated scores were Effort (13.4, IQR = [8.12, 17.14]), Mental Demand (13.4, IQR = [8.72, 17.1]), and Temporal Demand (11.6, IQR = [6.71, 15.2]), while Frustration (7.94), Performance (5.63), and Physical Demand (5.29) were lower. This pattern-elevated cognitive and temporal demands with lower physical and emotional strain-was consistent across provider types. Among physicians (MDs), there was a significant negative correlation between individual task load (total NASA-TLX score) and team performance (total TEAM score), with Spearman's rank correlation coefficient ρ = -0.23 (95% credible interval = [-0.36 to -0.09]). In contrast, correlations for respiratory therapists (RTs) and registered nurses (RNs) were not statistically reliable, with ρ = -0.07 (95% CI = [-0.21 to 0.07]) and ρ = -0.02 (95% CI = [-0.16 to 0.13]), respectively. For MDs, higher levels of Frustration, Mental Demand, Temporal Demand, and Effort, along with lower self-rated Performance, were significantly associated with lower TEAM scores. No comparable associations were observed for RNs or RTs. Finally, all MD-RN NASA-TLX dimension pairs were significantly correlated, ρ between 0.31 and 0.44; and essentially no correlations were found between the RN-RT or MD-RT comparisons.</p><p><strong>Conclusions: </strong>We ","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Kessler Ii, Chanhee Park, Xiaomei Yang, Fengqian Chen, Arijit Duta, Lin Zou, Wei Chao, Brittney Williams
<p><strong>Introduction: </strong>Following traumatic injury, both the inflammatory and hemostatic systems are activated. Patients experience a systemic increase in circulating cytokines and coagulation leading to a greater risk of organ dysfunction. Post-trauma aeromedical evacuation exposes patients to hypobaria and potential hypoxia. We sought to assess the impact of hypobaria and hypoxic (H/H) on mortality, coagulation, and inflammation in a mouse model of polytrauma.</p><p><strong>Materials and methods: </strong>Eight- to 12-week-old male C57BL/6J mice were subjected to sham or polytrauma operation with the latter consisting of bowel ischemia via laparotomy and superior mesenteric artery (SMA) occlusion, gastrocnemius muscle crush, and tibia fracture. Sham mice were subjected to laparotomy only. Immediately post SMA reperfusion, animals were randomized to (1) 6 hours at sea level with normobaria and normoxia (N/N) conditions or (2) simulated aeromedical evacuation with H/H conditions. At 6 hours post SMA reperfusion, mice were subjected to general anesthesia, cardiac puncture blood draw, and bronchioalveolar lavage (BAL). Global coagulation was measured by rotational thromboelastometry (ROTEM), and plasma mediators were measured by enzyme-linked immunosorbent assay (ELISA) and Luminex. Extracellular vesicles (EVs) were isolated for treatment of mouse macrophages and naive mouse blood.</p><p><strong>Results: </strong>Compared to sham-operated mice, polytrauma mice under N/N conditions exhibited marked hypothermia (38.86 vs. 29.97 °C), systemic inflammation, and platelet activation as evidenced by an increase in plasma MIP-2, IL-6, and P-selectin, and developed alveolar inflammation with increases in BAL MIP-2 and IL-6 6 hours after traumatic injury. Extracellular vesicles isolated from polytrauma mice stimulated a greater release of both MIP-2 and IL-6 from mouse macrophages compared to EVs from sham mice. Polytrauma mice also demonstrated a decrease in platelets and an increase in maximum clot firmness (MCF) compared to sham. In polytrauma mice, H/H exposure significantly worsened hypothermia (N/N trauma vs. H/H trauma; 28.34 °C vs. 26.32 °C) and increased inflammation with elevated plasma levels of MIP-2 andIL-6, and higher MIP-2 in BAL samples. At higher concentrations, EVs isolated from H/H polytrauma mice stimulated a greater release of both MIP-2 and IL-6 from mouse macrophages compared to N/N polytrauma EVs. However, coagulation appeared to not be affected by the simulated aeromedical evacuation. Platelet count and MCF did not differ between H/H and N/N groups after polytrauma. Finally, polytrauma mice with H/H exposure had an increased mortality rate at 6 hours compared to those at sea level (N/N trauma vs. H/H trauma; 7.69% vs. 31.82%).</p><p><strong>Conclusions: </strong>The polytrauma model induces marked circulatory dysfunction, systemic inflammation, thrombocytopenia, and hypercoagulation in mice. Hypobaria and hypoxia exposure f
外伤性损伤后,炎症和止血系统都被激活。患者经历循环细胞因子和凝血系统的增加,导致器官功能障碍的风险更大。创伤后航空医疗后送使患者暴露于低血压和潜在的缺氧。我们试图评估低压和缺氧(H/H)对多发性创伤小鼠模型的死亡率、凝血和炎症的影响。材料与方法:8 ~ 12周龄雄性C57BL/6J小鼠进行假手术或多伤手术,后者包括剖腹肠缺血、肠系膜上动脉闭塞、腓肠肌挤压、胫骨骨折。假小鼠只接受剖腹手术。SMA再灌注后立即将动物随机分为(1)在海平面常压和常氧(N/N)条件下6小时或(2)在H/H条件下模拟航空医疗后送。SMA再灌注后6小时,小鼠进行全身麻醉、心脏穿刺抽血、细支气管肺泡灌洗(BAL)。采用旋转血栓弹性测量法(ROTEM)测量整体凝血,采用酶联免疫吸附试验(ELISA)和Luminex测量血浆介质。分离细胞外囊泡(EVs)用于处理小鼠巨噬细胞和小鼠幼稚血液。结果:与假手术小鼠相比,多创伤小鼠在N/N条件下表现出明显的低体温(38.86°C对29.97°C)、全身炎症和血小板活化(血浆MIP-2、IL-6和p -选择素增加),并在创伤后6小时出现肺泡炎症(BAL MIP-2和IL-6增加)。与假小鼠的EVs相比,从多发性创伤小鼠分离的细胞外囊泡刺激小鼠巨噬细胞释放更多的MIP-2和IL-6。与假手术相比,多发创伤小鼠也表现出血小板减少和最大凝块硬度(MCF)增加。在多创伤小鼠中,H/H暴露显著加重了低温(N/N创伤vs H/H创伤;28.34°C vs 26.32°C),炎症增加,血浆中MIP-2和il -6水平升高,BAL样本中MIP-2水平升高。在较高浓度下,与N/N多伤小鼠相比,从H/H多伤小鼠中分离的ev刺激小鼠巨噬细胞释放更多的MIP-2和IL-6。然而,凝血似乎不受模拟航空医疗后送的影响。多发性创伤后H/H组与N/N组血小板计数和MCF无显著差异。最后,与海平面下的小鼠相比,暴露于H/H的多伤小鼠在6小时的死亡率增加(N/N创伤vs H/H创伤;7.69% vs 31.82%)。结论:多发损伤模型可引起小鼠明显的循环功能障碍、全身炎症、血小板减少和高凝。低血压和低氧暴露进一步增加死亡率、循环功能障碍和多发外伤后的炎症。
{"title":"Impact of Hypobaria and Hypoxia Exposure on Mortality, Inflammation, and Coagulopathy in an Animal Model of Polytrauma.","authors":"John Kessler Ii, Chanhee Park, Xiaomei Yang, Fengqian Chen, Arijit Duta, Lin Zou, Wei Chao, Brittney Williams","doi":"10.1093/milmed/usag021","DOIUrl":"https://doi.org/10.1093/milmed/usag021","url":null,"abstract":"<p><strong>Introduction: </strong>Following traumatic injury, both the inflammatory and hemostatic systems are activated. Patients experience a systemic increase in circulating cytokines and coagulation leading to a greater risk of organ dysfunction. Post-trauma aeromedical evacuation exposes patients to hypobaria and potential hypoxia. We sought to assess the impact of hypobaria and hypoxic (H/H) on mortality, coagulation, and inflammation in a mouse model of polytrauma.</p><p><strong>Materials and methods: </strong>Eight- to 12-week-old male C57BL/6J mice were subjected to sham or polytrauma operation with the latter consisting of bowel ischemia via laparotomy and superior mesenteric artery (SMA) occlusion, gastrocnemius muscle crush, and tibia fracture. Sham mice were subjected to laparotomy only. Immediately post SMA reperfusion, animals were randomized to (1) 6 hours at sea level with normobaria and normoxia (N/N) conditions or (2) simulated aeromedical evacuation with H/H conditions. At 6 hours post SMA reperfusion, mice were subjected to general anesthesia, cardiac puncture blood draw, and bronchioalveolar lavage (BAL). Global coagulation was measured by rotational thromboelastometry (ROTEM), and plasma mediators were measured by enzyme-linked immunosorbent assay (ELISA) and Luminex. Extracellular vesicles (EVs) were isolated for treatment of mouse macrophages and naive mouse blood.</p><p><strong>Results: </strong>Compared to sham-operated mice, polytrauma mice under N/N conditions exhibited marked hypothermia (38.86 vs. 29.97 °C), systemic inflammation, and platelet activation as evidenced by an increase in plasma MIP-2, IL-6, and P-selectin, and developed alveolar inflammation with increases in BAL MIP-2 and IL-6 6 hours after traumatic injury. Extracellular vesicles isolated from polytrauma mice stimulated a greater release of both MIP-2 and IL-6 from mouse macrophages compared to EVs from sham mice. Polytrauma mice also demonstrated a decrease in platelets and an increase in maximum clot firmness (MCF) compared to sham. In polytrauma mice, H/H exposure significantly worsened hypothermia (N/N trauma vs. H/H trauma; 28.34 °C vs. 26.32 °C) and increased inflammation with elevated plasma levels of MIP-2 andIL-6, and higher MIP-2 in BAL samples. At higher concentrations, EVs isolated from H/H polytrauma mice stimulated a greater release of both MIP-2 and IL-6 from mouse macrophages compared to N/N polytrauma EVs. However, coagulation appeared to not be affected by the simulated aeromedical evacuation. Platelet count and MCF did not differ between H/H and N/N groups after polytrauma. Finally, polytrauma mice with H/H exposure had an increased mortality rate at 6 hours compared to those at sea level (N/N trauma vs. H/H trauma; 7.69% vs. 31.82%).</p><p><strong>Conclusions: </strong>The polytrauma model induces marked circulatory dysfunction, systemic inflammation, thrombocytopenia, and hypercoagulation in mice. Hypobaria and hypoxia exposure f","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joseph Salama, Jason A Unger, Summit R Kumar, Matthew Hayes, Caroline Murphy, Nicholas Orr, Michael April
Introduction: Chest pain is a frequent reason for evaluation at military treatment facilities in the deployed setting. Deployed persons are generally at low risk of coronary disease as the underlying cause for these symptoms; however, morbidity and mortality from acute coronary syndrome in an austere environment can be catastrophic. For theaters with access to computed tomography (CT), Coronary CT Angiography (CCTA) offers a diagnostic modality to effectively rule out this high-risk diagnosis in low to intermediate risk patients. The researchers present a descriptive analysis of CCTA use at a deployed Role 3 over a deployment rotation spanning 8 months.
Materials and methods: The researchers devised a CCTA protocol and delivered this diagnostic modality at a deployed Role 3 MTF. They included patients presenting with chest pain and stratified by the treating cleinician as intermediate risk given a history, electrocardiogram, age, cardiac risk factors, Troponin T, HEART score, and bedside echo when available. The CT scanner used by the researchers was a Siemens SOMATOM go, Top 128 slice, 70 cm bore, equipped with hardware to perform electrocardiography (ECG) gated studies and postprocessing. The researchers beta blocked patients to a target heart rate of 50-60 prior to each study, and administered a single 0.4 mg tab of sublingual nitroglycerin 4-7 minutes prior to starting angiography. They performed pre-angiography unenhanced CCTA to determine calcium score. Later, they performed ECG gated CCTA following intravenous (IV) contrast administration.
Results: The researchers performed four CCTA studies on symptomatic patients, each of whom also received a pre-angiogram CT calcium score. All four patients successfully completed the protocol. All four patients had a calcium score of 0. CCTA was low risk without any visible coronary disease for two patients and non-diagnostic for the remaining two patients. There was no major adverse event. One patient experienced a small volume IV access site infiltration at the end of the contrast bolus injection which did not limit that respective exam. The remaining patients did not experience any minor or major adverse events.
Conclusion: The initial data of this study is proof of concept that CCTA is feasible for assessing intermediate risk patients presenting with acute chest pain in the deployed setting, to rule our coronary pathology. The researchers' initial evaluation shows promise and suggests that this is a useful modality to continue to utilize and study in this environment.
{"title":"A Descriptive Analysis of Coronary Computed Tomography Angiography Results among Patients Presenting with Chest Pain in a Deployed Combat Environment.","authors":"Joseph Salama, Jason A Unger, Summit R Kumar, Matthew Hayes, Caroline Murphy, Nicholas Orr, Michael April","doi":"10.1093/milmed/usaf623","DOIUrl":"https://doi.org/10.1093/milmed/usaf623","url":null,"abstract":"<p><strong>Introduction: </strong>Chest pain is a frequent reason for evaluation at military treatment facilities in the deployed setting. Deployed persons are generally at low risk of coronary disease as the underlying cause for these symptoms; however, morbidity and mortality from acute coronary syndrome in an austere environment can be catastrophic. For theaters with access to computed tomography (CT), Coronary CT Angiography (CCTA) offers a diagnostic modality to effectively rule out this high-risk diagnosis in low to intermediate risk patients. The researchers present a descriptive analysis of CCTA use at a deployed Role 3 over a deployment rotation spanning 8 months.</p><p><strong>Materials and methods: </strong>The researchers devised a CCTA protocol and delivered this diagnostic modality at a deployed Role 3 MTF. They included patients presenting with chest pain and stratified by the treating cleinician as intermediate risk given a history, electrocardiogram, age, cardiac risk factors, Troponin T, HEART score, and bedside echo when available. The CT scanner used by the researchers was a Siemens SOMATOM go, Top 128 slice, 70 cm bore, equipped with hardware to perform electrocardiography (ECG) gated studies and postprocessing. The researchers beta blocked patients to a target heart rate of 50-60 prior to each study, and administered a single 0.4 mg tab of sublingual nitroglycerin 4-7 minutes prior to starting angiography. They performed pre-angiography unenhanced CCTA to determine calcium score. Later, they performed ECG gated CCTA following intravenous (IV) contrast administration.</p><p><strong>Results: </strong>The researchers performed four CCTA studies on symptomatic patients, each of whom also received a pre-angiogram CT calcium score. All four patients successfully completed the protocol. All four patients had a calcium score of 0. CCTA was low risk without any visible coronary disease for two patients and non-diagnostic for the remaining two patients. There was no major adverse event. One patient experienced a small volume IV access site infiltration at the end of the contrast bolus injection which did not limit that respective exam. The remaining patients did not experience any minor or major adverse events.</p><p><strong>Conclusion: </strong>The initial data of this study is proof of concept that CCTA is feasible for assessing intermediate risk patients presenting with acute chest pain in the deployed setting, to rule our coronary pathology. The researchers' initial evaluation shows promise and suggests that this is a useful modality to continue to utilize and study in this environment.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bryce Pierce, Erin S Barry, Leslie Vojta, Melissa Myers, Hannah Kleber, Cynthia Shen, Yen Lee
<p><strong>Introduction: </strong>Early leadership development is an increasing focus in both military and civilian undergraduate medical education, where physicians are expected to lead multidisciplinary teams and perform under complex, high-stakes conditions. Despite a growing number of leadership training programs, few studies have evaluated the longitudinal progression of leadership competencies across medical school using standardized, validated tools. The Uniformed Services University (USU) has implemented a longitudinal leadership curriculum grounded in the Leader-Follower (LF2) Framework, which includes 4 core elements: Character, Competence, Context, and Communication. This study aimed to determine whether leadership performance during a third-year immersive field practicum (Operation Gunpowder) correlates with and predicts subsequent performance in a fourth-year practicum (Operation Bushmaster) using the same standardized assessment approach.</p><p><strong>Materials and methods: </strong>This observational cohort study included 151 students from USU's class of 2025 who completed both military field practicums (MFP). Both MFPs assessed students using a validated 5-item leadership evaluation tool aligned with the LF2 framework. Each element was rated on a 4-point Likert scale. Pearson correlation coefficients were calculated to assess associations between MFP leadership scores. Best subset regression was used to identify which Gunpowder leadership elements best predicted Bushmaster performance. The study was approved by the USU Institutional Review Board (Protocol Number: KM83XV).</p><p><strong>Results: </strong>The total leadership score from Gunpowder was positively correlated with the total score from Bushmaster. Among individual elements, only Leadership Transcendent Skills (LTS) and Role-Specific Competence during Gunpowder showed positive correlations with their corresponding Bushmaster scores. LTS in Gunpowder was significantly correlated with all 5 leadership elements in Bushmaster, while Role-Specific Competence correlated with all Bushmaster elements except Communication. Regression analysis identified LTS as the strongest and most consistent predictor of Bushmaster performance across multiple domains, including Character, Communication, and LTS itself. In contrast, Role-Specific Competence from Gunpowder only predicted the same element in Bushmaster. The overall Gunpowder sum score was not a significant predictor of any individual Bushmaster element.</p><p><strong>Conclusions: </strong>This study demonstrates that specific leadership traits assessed early in medical school, particularly LTS, predict future leadership performance in operationally realistic environments. The cross-domain predictive power of LTS suggests it may serve as a transferable core skill analogous to Trait Emotional Intelligence (Trait EI), reinforcing its potential value in early leadership curricula. In contrast, Role-Specific Competence appeared to be c
{"title":"Operation Gunpowder Leader Performance as a Predictor of Operation Bushmaster Leader Performance.","authors":"Bryce Pierce, Erin S Barry, Leslie Vojta, Melissa Myers, Hannah Kleber, Cynthia Shen, Yen Lee","doi":"10.1093/milmed/usag004","DOIUrl":"https://doi.org/10.1093/milmed/usag004","url":null,"abstract":"<p><strong>Introduction: </strong>Early leadership development is an increasing focus in both military and civilian undergraduate medical education, where physicians are expected to lead multidisciplinary teams and perform under complex, high-stakes conditions. Despite a growing number of leadership training programs, few studies have evaluated the longitudinal progression of leadership competencies across medical school using standardized, validated tools. The Uniformed Services University (USU) has implemented a longitudinal leadership curriculum grounded in the Leader-Follower (LF2) Framework, which includes 4 core elements: Character, Competence, Context, and Communication. This study aimed to determine whether leadership performance during a third-year immersive field practicum (Operation Gunpowder) correlates with and predicts subsequent performance in a fourth-year practicum (Operation Bushmaster) using the same standardized assessment approach.</p><p><strong>Materials and methods: </strong>This observational cohort study included 151 students from USU's class of 2025 who completed both military field practicums (MFP). Both MFPs assessed students using a validated 5-item leadership evaluation tool aligned with the LF2 framework. Each element was rated on a 4-point Likert scale. Pearson correlation coefficients were calculated to assess associations between MFP leadership scores. Best subset regression was used to identify which Gunpowder leadership elements best predicted Bushmaster performance. The study was approved by the USU Institutional Review Board (Protocol Number: KM83XV).</p><p><strong>Results: </strong>The total leadership score from Gunpowder was positively correlated with the total score from Bushmaster. Among individual elements, only Leadership Transcendent Skills (LTS) and Role-Specific Competence during Gunpowder showed positive correlations with their corresponding Bushmaster scores. LTS in Gunpowder was significantly correlated with all 5 leadership elements in Bushmaster, while Role-Specific Competence correlated with all Bushmaster elements except Communication. Regression analysis identified LTS as the strongest and most consistent predictor of Bushmaster performance across multiple domains, including Character, Communication, and LTS itself. In contrast, Role-Specific Competence from Gunpowder only predicted the same element in Bushmaster. The overall Gunpowder sum score was not a significant predictor of any individual Bushmaster element.</p><p><strong>Conclusions: </strong>This study demonstrates that specific leadership traits assessed early in medical school, particularly LTS, predict future leadership performance in operationally realistic environments. The cross-domain predictive power of LTS suggests it may serve as a transferable core skill analogous to Trait Emotional Intelligence (Trait EI), reinforcing its potential value in early leadership curricula. In contrast, Role-Specific Competence appeared to be c","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacob A Naylor, Michele Jonsson Funk, Shabbar I Ranapurwala, Michelle Canham Chervak, Evan Mayo-Wilson, Mikala K Bruno, Christian V Olivarez, Stephen W Marshall
Introduction: In 2020, the U.S. Army began implementation of the Holistic Health and Fitness (H2F) system to reduce musculoskeletal injury (MSKI) rates and expedite rehabilitation after injury. The purpose of this study was to describe the rates and characteristics of incident MSKIs evaluated by H2F physical therapists (PTs) and athletic trainers (ATs) in a U.S. Army Stryker brigade combat team from October 2021 to September 2022.
Materials and methods: In this retrospective observational study, we used negative binomial models and the H2F injury tracker and Army administrative data to estimate MSKI incidence rates for the overall brigade and within strata of battalion, age, sex, rank, race, and ethnicity. We repeated these estimates when standardized to the overall brigade population by battalion, age, sex, and rank. We characterized distributions of time from injury to evaluation, limited duty days (i.e., time-loss), and activity at time of injury. This research was determined exempt by academic and military Institutional Review Boards.
Results: The embedded H2F PTs and ATs evaluated 2,140 incident MSKIs in the brigade (4,780 person-years) for an overall rate of 39.1 MSKIs per 1,000 person-months. Battalion rates ranged from 31.8 (field artillery) to 50.0 (infantry) and did not change substantially after standardization. Embedded H2F PTs and ATs evaluated 63% of MSKIs within 1 week of onset, managed 59% without assigning time-loss, and found 51% of MSKIs occurred during unit physical fitness training.
Conclusions: These findings are consistent with the a priori expectation that embedded providers and the H2F system expedited access to MSKI evaluation and treatment. A strength of this study was our ability to estimate MSKI incidence rates and characterize MSKI evaluated in the H2F environment using a novel injury tracker coupled with administrative data. A limitation is that because of data deidentification, we could not measure cumulative time-loss. This descriptive observational study will help inform the findings of subsequent research on the effect of H2F implementation on MSKI outcomes.
{"title":"Descriptive Epidemiology of Musculoskeletal Injuries Presenting to an Embedded Holistic Health and Fitness (H2F) Team in a United States Army Stryker Brigade, October 2021-September 2022.","authors":"Jacob A Naylor, Michele Jonsson Funk, Shabbar I Ranapurwala, Michelle Canham Chervak, Evan Mayo-Wilson, Mikala K Bruno, Christian V Olivarez, Stephen W Marshall","doi":"10.1093/milmed/usaf645","DOIUrl":"https://doi.org/10.1093/milmed/usaf645","url":null,"abstract":"<p><strong>Introduction: </strong>In 2020, the U.S. Army began implementation of the Holistic Health and Fitness (H2F) system to reduce musculoskeletal injury (MSKI) rates and expedite rehabilitation after injury. The purpose of this study was to describe the rates and characteristics of incident MSKIs evaluated by H2F physical therapists (PTs) and athletic trainers (ATs) in a U.S. Army Stryker brigade combat team from October 2021 to September 2022.</p><p><strong>Materials and methods: </strong>In this retrospective observational study, we used negative binomial models and the H2F injury tracker and Army administrative data to estimate MSKI incidence rates for the overall brigade and within strata of battalion, age, sex, rank, race, and ethnicity. We repeated these estimates when standardized to the overall brigade population by battalion, age, sex, and rank. We characterized distributions of time from injury to evaluation, limited duty days (i.e., time-loss), and activity at time of injury. This research was determined exempt by academic and military Institutional Review Boards.</p><p><strong>Results: </strong>The embedded H2F PTs and ATs evaluated 2,140 incident MSKIs in the brigade (4,780 person-years) for an overall rate of 39.1 MSKIs per 1,000 person-months. Battalion rates ranged from 31.8 (field artillery) to 50.0 (infantry) and did not change substantially after standardization. Embedded H2F PTs and ATs evaluated 63% of MSKIs within 1 week of onset, managed 59% without assigning time-loss, and found 51% of MSKIs occurred during unit physical fitness training.</p><p><strong>Conclusions: </strong>These findings are consistent with the a priori expectation that embedded providers and the H2F system expedited access to MSKI evaluation and treatment. A strength of this study was our ability to estimate MSKI incidence rates and characterize MSKI evaluated in the H2F environment using a novel injury tracker coupled with administrative data. A limitation is that because of data deidentification, we could not measure cumulative time-loss. This descriptive observational study will help inform the findings of subsequent research on the effect of H2F implementation on MSKI outcomes.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Jimena Huaman, Michael D April, Julie A Rizzo, Matthew D Smith, Sylvain Cardin, Steven G Schauer
Introduction: Airway compromise is an urgent and life-threatening challenge that commonly occurs on the battlefield. Effective airway management on the battlefield is critical for reducing preventable deaths. This review summarizes the existing literature on airway management in the deployed combat setting.
Materials and methods: We conducted a scoping review using the PRISMA-ScR checklist. We used PubMed and Google Scholar to identify relevant literature from 2001 to 2025 which reflects the years for the Global War On Terrorism. Studies were eligible if they reported on airway interventions in the combat setting.
Results: There were 30 airway studies that met inclusion for this review. Of the studies included in this review, 3 were focused on endotracheal intubation (ETI), 3 were focused on cricothyrotomy, 1 was focused on supraglottic airways, and 23 evaluated more than 1 airway method. The studies included 4 prospective observational studies, and 25 retrospective observational studies. Overall, ETI was the most commonly reported airway procedure with the majority performed by medical officers in both the fixed and prehospital settings. Cricothyrotomy was the second most commonly reported with a relatively low incidence and high complication. Multiple studies highlighted gaps in skills training as well as technology as a complicating factors.
Conclusions: Effective airway management is critical for reducing preventable deaths on the battlefield. Endotracheal intubation is the most common advanced airway intervention, while cricothyrotomy and supraglottic airways are less common and show variable success. Ongoing gaps in training, documentation, and equipment access highlight the need for standardized airway protocols and improved training programs to improve battlefield survival among casualties requiring an advanced airway.
{"title":"A Scoping Review on Military Airway Studies.","authors":"R Jimena Huaman, Michael D April, Julie A Rizzo, Matthew D Smith, Sylvain Cardin, Steven G Schauer","doi":"10.1093/milmed/usag001","DOIUrl":"https://doi.org/10.1093/milmed/usag001","url":null,"abstract":"<p><strong>Introduction: </strong>Airway compromise is an urgent and life-threatening challenge that commonly occurs on the battlefield. Effective airway management on the battlefield is critical for reducing preventable deaths. This review summarizes the existing literature on airway management in the deployed combat setting.</p><p><strong>Materials and methods: </strong>We conducted a scoping review using the PRISMA-ScR checklist. We used PubMed and Google Scholar to identify relevant literature from 2001 to 2025 which reflects the years for the Global War On Terrorism. Studies were eligible if they reported on airway interventions in the combat setting.</p><p><strong>Results: </strong>There were 30 airway studies that met inclusion for this review. Of the studies included in this review, 3 were focused on endotracheal intubation (ETI), 3 were focused on cricothyrotomy, 1 was focused on supraglottic airways, and 23 evaluated more than 1 airway method. The studies included 4 prospective observational studies, and 25 retrospective observational studies. Overall, ETI was the most commonly reported airway procedure with the majority performed by medical officers in both the fixed and prehospital settings. Cricothyrotomy was the second most commonly reported with a relatively low incidence and high complication. Multiple studies highlighted gaps in skills training as well as technology as a complicating factors.</p><p><strong>Conclusions: </strong>Effective airway management is critical for reducing preventable deaths on the battlefield. Endotracheal intubation is the most common advanced airway intervention, while cricothyrotomy and supraglottic airways are less common and show variable success. Ongoing gaps in training, documentation, and equipment access highlight the need for standardized airway protocols and improved training programs to improve battlefield survival among casualties requiring an advanced airway.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kevin D Anderson, Brianna L Middel, Austin J Klomp
Hereditary spherocytosis and sickle cell disease are two distinct hematologic diseases that affect the morphology of the red blood cell, causing implications related to splenic sequestration. Concurrent disease is very rare, with even fewer reported instances requiring surgical intervention. Furthermore, an individual with a third concomitant hematologic abnormality such as Factor VII deficiency, which degrades the normal clotting cascade, has not previously been reported. We describe an active-duty servicemember with known hereditary spherocytosis, sickle cell trait, and Factor VII deficiency who had recurrent worsening pain crises post-flight. The resulting hepatobiliary and splenic damage that ensued ultimately required splenectomy. These diseases in combination further enhance risks associated with splenic damage and intra-operative bleeding, with special consideration for intra-operative risk management and long-term sequala from end-organ damage. The military population exacerbates these conditions where physical exertion, high-altitude travel, and rapid geographic reassignment are considered the norm. This case of a servicemember with a unique disease triad managed successfully with surgical correction underscores the importance of individualized care planning and consideration of duty readiness.
{"title":"A Triad of Hematologic Diseases in a Military Member Requiring Splenectomy Case Report.","authors":"Kevin D Anderson, Brianna L Middel, Austin J Klomp","doi":"10.1093/milmed/usag017","DOIUrl":"https://doi.org/10.1093/milmed/usag017","url":null,"abstract":"<p><p>Hereditary spherocytosis and sickle cell disease are two distinct hematologic diseases that affect the morphology of the red blood cell, causing implications related to splenic sequestration. Concurrent disease is very rare, with even fewer reported instances requiring surgical intervention. Furthermore, an individual with a third concomitant hematologic abnormality such as Factor VII deficiency, which degrades the normal clotting cascade, has not previously been reported. We describe an active-duty servicemember with known hereditary spherocytosis, sickle cell trait, and Factor VII deficiency who had recurrent worsening pain crises post-flight. The resulting hepatobiliary and splenic damage that ensued ultimately required splenectomy. These diseases in combination further enhance risks associated with splenic damage and intra-operative bleeding, with special consideration for intra-operative risk management and long-term sequala from end-organ damage. The military population exacerbates these conditions where physical exertion, high-altitude travel, and rapid geographic reassignment are considered the norm. This case of a servicemember with a unique disease triad managed successfully with surgical correction underscores the importance of individualized care planning and consideration of duty readiness.</p>","PeriodicalId":18638,"journal":{"name":"Military Medicine","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}