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Clinical Impact of Sarcopenia Screening on Long‐Term Mortality in Patients Undergoing Coronary Bypass Grafting 肌肉疏松症筛查对冠状动脉旁路移植术患者长期死亡率的临床影响
IF 8.9 1区 医学 Pub Date : 2024-11-08 DOI: 10.1002/jcsm.13645
Seung Hun Lee, Jinhwan Jo, Jeong Hoon Yang, Sung Mok Kim, Ki Hong Choi, Young Bin Song, Dong Seop Jeong, Joo Myung Lee, Taek Kyu Park, Joo‐Yong Hahn, Seung‐Hyuk Choi, Su Ryeun Chung, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Hyeon‐Cheol Gwon, Young Tak Lee
BackgroundSarcopenia is an aging‐related condition characterized by loss of skeletal muscle mass and is an indicator of subclinical atherosclerosis. The relationship between reduced muscle mass and long‐term clinical outcomes in patients with advanced coronary artery disease who have undergone coronary artery bypass grafting (CABG) is not fully understood. This study is sought to evaluate the prognostic implications of sarcopenia screening in patients undergoing CABG.MethodsA total of 2810 patients who underwent CABG were analysed and classified according to presence of reduced muscle mass. The skeletal muscle index (SMI) was calculated as L3 muscle area (cm2)/height (m)2 on computed tomography. Reduced SMI was defined as SMI ≤ 45 cm2/m2 in male and ≤ 38 cm2/m2 in female. The primary outcome was all‐cause mortality, and survival analysis was performed using the Kaplan–Meier method and compared with the log‐rank test.ResultsThe median follow‐up was 8.7 years, and 924 patients (32.9%) had reduced SMI. Patients with reduced SMI were older (67.7 ± 8.8 vs. 62.2 ± 9.8 years; p < 0.001) and less frequently male (69.8% vs. 81.1%; p < 0.001). SMI was significantly associated with risk of death on a restricted cubic spline curve (HR = 1.04 per‐1 decrease; 95% CI 1.03–1.05; p < 0.001). Patients with reduced SMI had a higher incidence of long‐term mortality than those with preserved SMI (survival rate 41.4% vs. 62.8%; HRadj = 1.18, 95% CI 1.03–1.36, p = 0.020). Subgroup analysis showed that the prognostic implication of reduced SMI on long‐term survival was more evident in male (HRadj = 2.01, 95% CI 1.72–2.35) than female (HRadj = 1.28, 95% CI 0.98–1.68) (interaction p = 0.006).ConclusionsReduced muscle mass, defined by SMI on computed tomography, was associated with long‐term mortality after CABG. These results provide contemporary data to allow the evaluation of physical frailty in patients with advanced coronary artery disease before surgery.Trial Registration: Long‐Term Outcomes and Prognostic Factors in Patients Undergoing CABG or PCI: NCT03870815
背景肌肉疏松症是一种与衰老有关的疾病,其特点是骨骼肌量减少,是亚临床动脉粥样硬化的一个指标。接受冠状动脉旁路移植术(CABG)的晚期冠状动脉疾病患者肌肉质量下降与长期临床预后之间的关系尚未完全明了。本研究旨在评估肌肉疏松症筛查对接受冠状动脉旁路移植术患者预后的影响。方法:本研究共分析了 2810 名接受冠状动脉旁路移植术的患者,并根据肌肉质量是否减少进行了分类。骨骼肌指数(SMI)根据计算机断层扫描的 L3 肌肉面积(平方厘米)/身高(米)2 计算得出。男性骨骼肌指数≤45 cm2/m2,女性骨骼肌指数≤38 cm2/m2,即为骨骼肌指数降低。主要结果是全因死亡率,采用 Kaplan-Meier 法进行生存分析,并用对数秩检验进行比较。结果中位随访时间为 8.7 年,924 名患者(32.9%)的 SMI 降低。SMI降低的患者年龄较大(67.7 ± 8.8 岁 vs. 62.2 ± 9.8 岁;p < 0.001),男性较少(69.8% vs. 81.1%;p < 0.001)。在限制性立方样条曲线上,SMI 与死亡风险明显相关(HR = 1.04 per-1 decrease; 95% CI 1.03-1.05; p <0.001)。与保留 SMI 的患者相比,SMI 降低的患者的长期死亡率更高(存活率为 41.4% 对 62.8%;HRadj = 1.18,95% CI 1.03-1.36,p = 0.020)。亚组分析显示,SMI降低对长期生存的预后影响在男性(HRadj = 2.01,95% CI 1.72-2.35)比女性(HRadj = 1.28,95% CI 0.98-1.68)更明显(交互作用 p = 0.006)。这些结果为晚期冠状动脉疾病患者在手术前评估体质虚弱程度提供了现代数据:接受 CABG 或 PCI 患者的长期结果和预后因素:NCT03870815
{"title":"Clinical Impact of Sarcopenia Screening on Long‐Term Mortality in Patients Undergoing Coronary Bypass Grafting","authors":"Seung Hun Lee, Jinhwan Jo, Jeong Hoon Yang, Sung Mok Kim, Ki Hong Choi, Young Bin Song, Dong Seop Jeong, Joo Myung Lee, Taek Kyu Park, Joo‐Yong Hahn, Seung‐Hyuk Choi, Su Ryeun Chung, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Hyeon‐Cheol Gwon, Young Tak Lee","doi":"10.1002/jcsm.13645","DOIUrl":"https://doi.org/10.1002/jcsm.13645","url":null,"abstract":"BackgroundSarcopenia is an aging‐related condition characterized by loss of skeletal muscle mass and is an indicator of subclinical atherosclerosis. The relationship between reduced muscle mass and long‐term clinical outcomes in patients with advanced coronary artery disease who have undergone coronary artery bypass grafting (CABG) is not fully understood. This study is sought to evaluate the prognostic implications of sarcopenia screening in patients undergoing CABG.MethodsA total of 2810 patients who underwent CABG were analysed and classified according to presence of reduced muscle mass. The skeletal muscle index (SMI) was calculated as L3 muscle area (cm<jats:sup>2</jats:sup>)/height (m)<jats:sup>2</jats:sup> on computed tomography. Reduced SMI was defined as SMI ≤ 45 cm<jats:sup>2</jats:sup>/m<jats:sup>2</jats:sup> in male and ≤ 38 cm<jats:sup>2</jats:sup>/m<jats:sup>2</jats:sup> in female. The primary outcome was all‐cause mortality, and survival analysis was performed using the Kaplan–Meier method and compared with the log‐rank test.ResultsThe median follow‐up was 8.7 years, and 924 patients (32.9%) had reduced SMI. Patients with reduced SMI were older (67.7 ± 8.8 vs. 62.2 ± 9.8 years; <jats:italic>p</jats:italic> &lt; 0.001) and less frequently male (69.8% vs. 81.1%; <jats:italic>p</jats:italic> &lt; 0.001). SMI was significantly associated with risk of death on a restricted cubic spline curve (HR = 1.04 per‐1 decrease; 95% CI 1.03–1.05; <jats:italic>p</jats:italic> &lt; 0.001). Patients with reduced SMI had a higher incidence of long‐term mortality than those with preserved SMI (survival rate 41.4% vs. 62.8%; HR<jats:sub>adj</jats:sub> = 1.18, 95% CI 1.03–1.36, <jats:italic>p</jats:italic> = 0.020). Subgroup analysis showed that the prognostic implication of reduced SMI on long‐term survival was more evident in male (HR<jats:sub>adj</jats:sub> = 2.01, 95% CI 1.72–2.35) than female (HR<jats:sub>adj</jats:sub> = 1.28, 95% CI 0.98–1.68) (interaction <jats:italic>p</jats:italic> = 0.006).ConclusionsReduced muscle mass, defined by SMI on computed tomography, was associated with long‐term mortality after CABG. These results provide contemporary data to allow the evaluation of physical frailty in patients with advanced coronary artery disease before surgery.Trial Registration: Long‐Term Outcomes and Prognostic Factors in Patients Undergoing CABG or PCI: NCT03870815","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":"34 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142597132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Artificial Intelligence Approach for Test‐Free Identification of Sarcopenia 免测试识别 "肌肉疏松症 "的人工智能方法
IF 8.9 1区 医学 Pub Date : 2024-11-08 DOI: 10.1002/jcsm.13627
Liangyu Yin, Jinghong Zhao
BackgroundThe diagnosis of sarcopenia relies extensively on human and equipment resources and requires individuals to personally visit medical institutions. The objective of this study was to develop a test‐free, self‐assessable approach to identify sarcopenia by utilizing artificial intelligence techniques and representative real‐world data.MethodsThis multicentre study enrolled 11 661 middle‐aged and older adults from a national survey initialized in 2011. Follow‐up data from the baseline cohort collected in 2013 (<jats:italic>n</jats:italic> = 9403) and 2015 (<jats:italic>n</jats:italic> = 10 356) were used for validation. Sarcopenia was retrospectively diagnosed using the Asian Working Group for Sarcopenia 2019 framework. Baseline age, sex, height, weight and 20 functional capacity (FC)–related binary indices (activities of daily living = 6, instrumental activities of daily living = 5 and other FC indices = 9) were considered as predictors. Multiple machine learning (ML) models were trained and cross‐validated using 70% of the baseline data to predict sarcopenia. The remaining 30% of the baseline data, along with two follow‐up datasets (<jats:italic>n</jats:italic> = 9403 and <jats:italic>n</jats:italic> = 10 356, respectively), were used to assess model performance.ResultsThe study included 5634 men and 6027 women (median age = 57.0 years). Sarcopenia was identified in 1288 (11.0%) individuals. Among the 20 FC indices, the running/jogging 1 km item showed the highest predictive value for sarcopenia (AUC [95%CI] = 0.633 [0.620–0.647]). From the various ML models assessed, a 24‐variable gradient boosting classifier (GBC) model was selected. This GBC model demonstrated favourable performance in predicting sarcopenia in the holdout data (AUC [95%CI] = 0.831 [0.808–0.853], accuracy = 0.889, recall = 0.441, precision = 0.475, F1 score = 0.458, Kappa = 0.396 and Matthews correlation coefficient = 0.396). Further model validation on the temporal scale using two longitudinal datasets also demonstrated good performance (AUC [95%CI]: 0.833 [0.818–0.848] and 0.852 [0.840–0.865], respectively). The model's built‐in feature importance ranking and the SHapley Additive exPlanations method revealed that lifting 5 kg and running/jogging 1 km were relatively important variables among the 20 FC items contributing to the model's predictive capacity, respectively. The calibration curve of the model indicated good agreement between predictions and actual observations (Hosmer and Lemeshow <jats:italic>p</jats:italic> = 0.501, 0.451 and 0.374 for the three test sets, respectively), and decision curve analysis supported its clinical usefulness. The model was implemented as an online web application and exported as a deployable binary file, allowing for flexible, individualized risk assessment.ConclusionsWe developed an artificial intelligence model that can assist in the identification of sarcopenia, particularly in settings lacking the necessary resources for a comp
背景肌肉疏松症的诊断广泛依赖于人力和设备资源,需要个人亲自前往医疗机构。本研究旨在利用人工智能技术和具有代表性的真实世界数据,开发一种免测试、可自我评估的方法来识别肌肉疏松症。方法这项多中心研究从 2011 年开始的一项全国调查中招募了 11 661 名中老年人。2013年(n = 9403)和2015年(n = 10 356)收集的基线队列随访数据用于验证。采用亚洲肌少症工作组 2019 年框架对肌少症进行回顾性诊断。基线年龄、性别、身高、体重和20个与功能能力(FC)相关的二元指数(日常生活活动指数=6、工具性日常生活活动指数=5和其他功能能力指数=9)被视为预测因素。使用 70% 的基线数据对多个机器学习 (ML) 模型进行了训练和交叉验证,以预测肌肉疏松症。剩余的 30% 基线数据以及两个随访数据集(分别为 9403 人和 10 356 人)用于评估模型性能。发现有 1288 人(11.0%)患有肌肉疏松症。在 20 个 FC 指数中,跑步/慢跑 1 公里项目对肌少症的预测价值最高(AUC [95%CI] = 0.633 [0.620-0.647])。在评估的各种多变量模型中,选出了一个 24 变量梯度提升分类器(GBC)模型。该 GBC 模型在预测保留数据中的肌肉疏松症方面表现良好(AUC [95%CI] = 0.831 [0.808-0.853]、准确率 = 0.889、召回率 = 0.441、精确度 = 0.475、F1 分数 = 0.458、Kappa = 0.396 和马修斯相关系数 = 0.396)。使用两个纵向数据集对时间尺度进行的进一步模型验证也显示出良好的性能(AUC [95%CI]:分别为 0.833 [0.818-0.848] 和 0.852 [0.840-0.865])。模型内置的特征重要性排序和 SHapley Additive exPlanations 方法显示,在 20 个 FC 项目中,举重 5 公斤和跑步/慢跑 1 公里分别是对模型预测能力有贡献的相对重要的变量。该模型的校准曲线表明,预测结果与实际观测结果之间具有良好的一致性(三个测试集的 Hosmer 和 Lemeshow p 分别为 0.501、0.451 和 0.374),而决策曲线分析也证明了该模型的临床实用性。该模型以在线网络应用程序的形式实施,并导出为可部署的二进制文件,从而可进行灵活、个性化的风险评估。结论我们开发了一种人工智能模型,可帮助识别肌少症,尤其是在缺乏必要资源进行全面诊断的情况下。这些发现为改进决策和促进肌少症新型管理策略的开发提供了可能。
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引用次数: 0
GABA Prevents Sarcopenia by Regulation of Muscle Protein Degradation and Inflammaging in 23‐ to 25‐Month‐Old Female Mice GABA 可通过调节 23 至 25 个月大雌性小鼠的肌肉蛋白降解和炎症反应预防肌肉疏松症
IF 8.9 1区 医学 Pub Date : 2024-11-08 DOI: 10.1002/jcsm.13646
Gunju Song, Hyun‐Ji Oh, Heegu Jin, Hyein Han, Boo‐Yong Lee
BackgroundSarcopenia is the gradual decrease in skeletal muscle mass, strength and function in elderly individuals. Gamma‐aminobutyric acid (GABA) is a neurotransmitter naturally produced from glutamate by the enzyme glutamic acid decarboxylase. Age‐related decline in GABA is linked to age‐related motor and sensory decline and seems to affect sarcopenia, yet no detailed study has been conducted. In this study, we aimed to investigate the effect of GABA on improving sarcopenia by suppressing muscle protein degradation through supplementing decreased GABA in old mice.MethodsGABA (10 or 30 mg/kg/day) was orally administered daily to young (3 months) and old (21–23 months) C57BL/6 mice for 7 weeks. The body weight and grip strength of the mice were measured weekly at the same time. After sacrificing the mice, the quadriceps and gastrocnemius muscles were excised from their hind limbs, and the spleen and serum were collected. Histological, biochemical and molecular analyses were conducted in various experiments.ResultsThe administration of GABA increased muscle strength (+41%, +70% compared to the aged mouse control group, GABA at doses of 10 or 30 mg/kg/day respectively, p < 0.05) and muscle mass (quadriceps: +28%, +46%; gastrocnemius: +12%, +19%, p < 0.05) in old mice. This increase was accompanied by a cross‐sectional area (CSA) increase in the quadriceps and gastrocnemius muscle (p < 0.05). The administration of GABA increased IGF‐1 levels in serum (p < 0.05), leading to the activation of muscle protein synthesis. We found that GABA inhibits sarcopenia by regulating muscle protein degradation through the activation of Akt/mTOR/FoxO3a signalling pathways. GABA also regulates inflammaging, which is a hallmark of age‐related muscle atrophy. There was a significant increase in the F4/80 + CD11b + total macrophage ratio in gastrocnemius and spleen, especially the M1 macrophage ratio increased in old mice. However, GABA administration was effective in suppressing M1 macrophages (gastrocnemius: −40%, − 53%; spleen: −22%, −26%, p < 0.05). Pro‐inflammatory cytokines such as TNF‐α and IL‐6, primarily secreted by M1 macrophages, are also decreased by treatment with GABA (TNF‐α: −24%, −27%; IL‐6: −45%, −59%, p < 0.05).ConclusionsTogether, this study demonstrates the importance of GABA in maintaining muscle and low‐chronic inflammation during ageing. We suggest that GABA shows potential as a substance that can effectively address sarcopenia and enhance the overall lifespan and well‐being of older individuals.
背景疏松症是指老年人的骨骼肌质量、力量和功能逐渐下降。γ-氨基丁酸(GABA)是一种神经递质,由谷氨酸脱羧酶从谷氨酸中自然生成。与年龄相关的 GABA 下降与与年龄相关的运动和感觉衰退有关,并且似乎会影响到肌肉疏松症,但目前还没有进行过详细的研究。本研究旨在探讨 GABA 通过补充老年小鼠体内减少的 GABA 来抑制肌肉蛋白质降解,从而改善肌肉疏松症的效果。同时每周测量小鼠的体重和握力。将小鼠处死后,切除其后肢股四头肌和腓肠肌,收集脾脏和血清。结果服用 GABA 可增加老龄小鼠的肌肉力量(与老龄小鼠对照组相比,GABA 剂量分别为 10 或 30 毫克/千克/天时,分别增加 41% 和 70%,p < 0.05)和肌肉质量(股四头肌:分别增加 28% 和 46%;腓肠肌:分别增加 12% 和 19%,p < 0.05)。这种增加伴随着股四头肌和腓肠肌横截面积(CSA)的增加(p < 0.05)。服用 GABA 能提高血清中 IGF-1 的水平(p < 0.05),从而激活肌肉蛋白质的合成。我们发现,GABA 可通过激活 Akt/mTOR/FoxO3a 信号通路,调节肌肉蛋白降解,从而抑制肌肉疏松症。GABA 还能调节炎症反应,而炎症反应是与年龄有关的肌肉萎缩的标志。老年小鼠腓肠肌和脾脏中的F4/80 + CD11b + 总巨噬细胞比率明显增加,尤其是M1巨噬细胞比率增加。然而,服用 GABA 能有效抑制 M1 巨噬细胞(腓肠肌:-40%,-53%;脾脏:-22%,-26%,p <0.05)。主要由 M1 巨噬细胞分泌的促炎细胞因子如 TNF-α 和 IL-6 也会因 GABA 的治疗而减少(TNF-α:-24%,-27%;IL-6:-45%,-59%,p <0.05)。我们认为,GABA 具有作为一种物质的潜力,可有效解决肌肉疏松症,并提高老年人的整体寿命和福祉。
{"title":"GABA Prevents Sarcopenia by Regulation of Muscle Protein Degradation and Inflammaging in 23‐ to 25‐Month‐Old Female Mice","authors":"Gunju Song, Hyun‐Ji Oh, Heegu Jin, Hyein Han, Boo‐Yong Lee","doi":"10.1002/jcsm.13646","DOIUrl":"https://doi.org/10.1002/jcsm.13646","url":null,"abstract":"BackgroundSarcopenia is the gradual decrease in skeletal muscle mass, strength and function in elderly individuals. Gamma‐aminobutyric acid (GABA) is a neurotransmitter naturally produced from glutamate by the enzyme glutamic acid decarboxylase. Age‐related decline in GABA is linked to age‐related motor and sensory decline and seems to affect sarcopenia, yet no detailed study has been conducted. In this study, we aimed to investigate the effect of GABA on improving sarcopenia by suppressing muscle protein degradation through supplementing decreased GABA in old mice.MethodsGABA (10 or 30 mg/kg/day) was orally administered daily to young (3 months) and old (21–23 months) C57BL/6 mice for 7 weeks. The body weight and grip strength of the mice were measured weekly at the same time. After sacrificing the mice, the quadriceps and gastrocnemius muscles were excised from their hind limbs, and the spleen and serum were collected. Histological, biochemical and molecular analyses were conducted in various experiments.ResultsThe administration of GABA increased muscle strength (+41%, +70% compared to the aged mouse control group, GABA at doses of 10 or 30 mg/kg/day respectively, <jats:italic>p</jats:italic> &lt; 0.05) and muscle mass (quadriceps: +28%, +46%; gastrocnemius: +12%, +19%, <jats:italic>p</jats:italic> &lt; 0.05) in old mice. This increase was accompanied by a cross‐sectional area (CSA) increase in the quadriceps and gastrocnemius muscle (<jats:italic>p</jats:italic> &lt; 0.05). The administration of GABA increased IGF‐1 levels in serum (<jats:italic>p</jats:italic> &lt; 0.05), leading to the activation of muscle protein synthesis. We found that GABA inhibits sarcopenia by regulating muscle protein degradation through the activation of Akt/mTOR/FoxO3a signalling pathways. GABA also regulates inflammaging, which is a hallmark of age‐related muscle atrophy. There was a significant increase in the F4/80 + CD11b + total macrophage ratio in gastrocnemius and spleen, especially the M1 macrophage ratio increased in old mice. However, GABA administration was effective in suppressing M1 macrophages (gastrocnemius: −40%, − 53%; spleen: −22%, −26%, <jats:italic>p</jats:italic> &lt; 0.05). Pro‐inflammatory cytokines such as TNF‐α and IL‐6, primarily secreted by M1 macrophages, are also decreased by treatment with GABA (TNF‐α: −24%, −27%; IL‐6: −45%, −59%, <jats:italic>p</jats:italic> &lt; 0.05).ConclusionsTogether, this study demonstrates the importance of GABA in maintaining muscle and low‐chronic inflammation during ageing. We suggest that GABA shows potential as a substance that can effectively address sarcopenia and enhance the overall lifespan and well‐being of older individuals.","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":"10 1","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142598033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Diagnosis of Sarcopenia by Evaluating Skeletal Muscle Mass by Adjusted Bioimpedance Analysis Validated With Dual-Energy X-Ray Absorptiometry' by Cheng et al. 就 Cheng 等人撰写的 "通过调整生物阻抗分析评估骨骼肌质量并用双能量 X 射线吸收测量法验证,从而诊断'肌肉疏松症'"发表评论。
IF 8.9 1区 医学 Pub Date : 2024-11-07 DOI: 10.1002/jcsm.13587
Hyunjee Kim
{"title":"Comment on 'Diagnosis of Sarcopenia by Evaluating Skeletal Muscle Mass by Adjusted Bioimpedance Analysis Validated With Dual-Energy X-Ray Absorptiometry' by Cheng et al.","authors":"Hyunjee Kim","doi":"10.1002/jcsm.13587","DOIUrl":"https://doi.org/10.1002/jcsm.13587","url":null,"abstract":"","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Detection of Cancer-Associated Cachexia in Lung Cancer Patients Using Whole-Body [18F]FDG-PET/CT Imaging: A Multicentre Study' by Ferrara et al. 就 Ferrara 等人的 "使用全身 [18F]FDG-PET/CT 成像检测肺癌患者的癌症相关恶病质:多中心研究 "的评论
IF 8.9 1区 医学 Pub Date : 2024-11-06 DOI: 10.1002/jcsm.13656
Hao Chen, Xiangyu Shen, Xiaodong Chen
{"title":"Comment on 'Detection of Cancer-Associated Cachexia in Lung Cancer Patients Using Whole-Body [<sup>18</sup>F]FDG-PET/CT Imaging: A Multicentre Study' by Ferrara et al.","authors":"Hao Chen, Xiangyu Shen, Xiaodong Chen","doi":"10.1002/jcsm.13656","DOIUrl":"https://doi.org/10.1002/jcsm.13656","url":null,"abstract":"","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Overall Mortality for Community-Dwelling Adults Over 50 Years at Risk of Malnutrition' by Gittins et al. 就 Gittins 等人撰写的 "50 岁以上有营养不良风险的社区居住成年人的总体死亡率 "发表评论。
IF 8.9 1区 医学 Pub Date : 2024-11-06 DOI: 10.1002/jcsm.13632
Yizhuan Huang, Han Wang
{"title":"Comment on 'Overall Mortality for Community-Dwelling Adults Over 50 Years at Risk of Malnutrition' by Gittins et al.","authors":"Yizhuan Huang, Han Wang","doi":"10.1002/jcsm.13632","DOIUrl":"https://doi.org/10.1002/jcsm.13632","url":null,"abstract":"","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Association Between Dynapenic Obesity and Risk of Cardiovascular Disease: The Hisayama Study' by Setoyama et al. 就 Setoyama 等人的 "动态肥胖与心血管疾病风险之间的关系:濑户山等人的 "久山研究
IF 8.9 1区 医学 Pub Date : 2024-11-06 DOI: 10.1002/jcsm.13658
Han Wang, Yizhuan Huang
{"title":"Comment on 'Association Between Dynapenic Obesity and Risk of Cardiovascular Disease: The Hisayama Study' by Setoyama et al.","authors":"Han Wang, Yizhuan Huang","doi":"10.1002/jcsm.13658","DOIUrl":"https://doi.org/10.1002/jcsm.13658","url":null,"abstract":"","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Factors Associated With Skeletal Muscle Mass in Middle-Aged Men Living With HIV' by Xu et al. 对 Xu 等人撰写的 "中年男性艾滋病病毒感染者骨骼肌质量的相关因素 "发表评论
IF 8.9 1区 医学 Pub Date : 2024-11-06 DOI: 10.1002/jcsm.13655
Wanfeng Qian, Xiaodong Zhou
{"title":"Comment on 'Factors Associated With Skeletal Muscle Mass in Middle-Aged Men Living With HIV' by Xu et al.","authors":"Wanfeng Qian, Xiaodong Zhou","doi":"10.1002/jcsm.13655","DOIUrl":"https://doi.org/10.1002/jcsm.13655","url":null,"abstract":"","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Impact of Cachexia and First-Line Systemic Therapy for Previously Untreated Advanced Non-Small Cell Lung Cancer: NEJ050A' by Miura et al. 评论 Miura 等人撰写的 "Cachexia 和一线系统疗法对既往未治疗过的晚期非小细胞肺癌的影响:NEJ050A "的评论
IF 8.9 1区 医学 Pub Date : 2024-11-06 DOI: 10.1002/jcsm.13657
Wei-Zhen Tang, Wei-Ze Xu, Tai-Hang Liu
{"title":"Comment on 'Impact of Cachexia and First-Line Systemic Therapy for Previously Untreated Advanced Non-Small Cell Lung Cancer: NEJ050A' by Miura et al.","authors":"Wei-Zhen Tang, Wei-Ze Xu, Tai-Hang Liu","doi":"10.1002/jcsm.13657","DOIUrl":"https://doi.org/10.1002/jcsm.13657","url":null,"abstract":"","PeriodicalId":186,"journal":{"name":"Journal of Cachexia, Sarcopenia and Muscle","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Prognostic Value of Cachexia Diagnosed by New Definition for Asian People in Older Patients With Heart Failure. 根据亚洲人新定义诊断的老年心力衰竭患者恶病质的患病率和预后价值
IF 8.9 1区 医学 Pub Date : 2024-11-05 DOI: 10.1002/jcsm.13610
Takumi Noda, Emi Maekawa, Daichi Maeda, Shota Uchida, Masashi Yamashita, Nobuaki Hamazaki, Kohei Nozaki, Hiroshi Saito, Kazuya Saito, Yuki Ogasahara, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Kentaro Jujo, Hiroshi Wada, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Shuhei Yamamoto, Naoki Aizawa, Ryusuke Yonezawa, Kazuhiro Oka, Junya Ako, Shin-Ichi Momomura, Nobuyuki Kagiyama, Yuya Matsue, Kentaro Kamiya

Background: The Asian Working Group for Cachexia (AWGC) proposed a new definition of cachexia; however, its impact on cachexia prevalence and overlaps with other conditions, such as sarcopenia and malnutrition, are unclear. We investigated these aspects and the prognostic value of cachexia based on the AWGC on mortality in older patients with heart failure (HF).

Methods: This study was a secondary analysis of a prospective multicentre cohort, namely, the FRAGILE-HF cohort study. Older (≥ 65 years) patients who had been hospitalized due to decompensated HF were enrolled. We assessed the presence/absence of cachexia based on the AWGC and Evans' criteria. Sarcopenia and malnutrition based on the Asian Working Group for Sarcopenia 2014 and the Global Leadership Initiative on Malnutrition criteria were also assessed to compare their prevalence and the overlaps between them. Patients were stratified in relation to the presence/absence of cachexia based on the AWGC criteria, and their mortality rates were compared.

Results: Of the 861 enrolled patients (median [interquartile range] age, 80 years [73-85 years]; male, 58.9%), cachexia, as evaluated based on the AWGC and Evans' criteria, sarcopenia and malnutrition, was present in 74.1%, 36.2%, 20.6% and 55.2% of patients, respectively. AWGC-defined cachexia was most common in the four conditions. All-cause death events occurred in 153 (18.1%) patients in 2 years. AWGC-defined cachexia (adjusted hazard ratio [aHRs], 1.442; 95% confidence interval [95% CI], 0.931-2.233; p = 0.101) was not associated with all-cause mortality in older patients with HF after adjusting for other HF prognosis factors, such as the B-type natriuretic peptide and the Meta-Analysis Global Group in Chronic risk score, whereas cachexia evaluated based on Evans's criteria (aHRs, 1.547; 95% CI, 1.118-2.141; p = 0.009), sarcopenia (aHRs, 1.737; 95% CI, 1.214-2.485; p = 0.003), and malnutrition (aHRs, 1.581; 95% CI, 1.094-2.284; p = 0.015) was associated with all-cause mortality.

Conclusions: Three-quarters of older patients with HF had cachexia as evaluated by the AWGC criteria, and this was not associated with a worse prognosis. As the new AWGC cachexia criteria will result in a significantly larger proportion of patients being diagnosed with cachexia, the implementation of the criteria in clinical practice requires further consideration.

Trial registration: UMIN-CTR unique identifier: UMIN000023929.

背景:亚洲恶病质工作组(AWGC)提出了恶病质的新定义;然而,该定义对恶病质患病率的影响以及与其他疾病(如肌肉疏松症和营养不良)的重叠情况尚不清楚。我们研究了这些方面以及基于 AWGC 的恶病质对老年心力衰竭(HF)患者死亡率的预后价值:本研究是对前瞻性多中心队列(即 FRAGILE-HF 队列研究)的二次分析。研究对象为因失代偿性心力衰竭住院的老年(≥ 65 岁)患者。我们根据 AWGC 和 Evans 标准评估是否存在恶病质。此外,我们还根据 "2014 年亚洲肌肉疏松症工作组 "和 "全球营养不良领导倡议 "的标准对肌肉疏松症和营养不良进行了评估,以比较它们的患病率和重叠程度。根据 AWGC 标准对患者是否存在恶病质进行了分层,并对其死亡率进行了比较:在 861 名入选患者中(中位数[四分位之间]年龄为 80 岁[73-85 岁];男性占 58.9%),根据 AWGC 和埃文斯标准、肌肉疏松症和营养不良进行评估的恶病质患者分别占 74.1%、36.2%、20.6% 和 55.2%。在这四种情况中,AWGC定义的恶病质最为常见。两年内有 153 名患者(18.1%)因各种原因死亡。AWGC定义的恶病质(调整后危险比[aHRs],1.442;95% 置信区间[95% CI],0.931-2.233;p = 0.101)在调整了其他HF预后因素(如B型钠尿肽和Meta-Analysis Global Group in Chronic风险评分)后,与老年HF患者的全因死亡率无关,而根据埃文斯标准评估的恶病质(aHRs,1.547;95% CI,1.118-2.141;p = 0.009)、肌肉疏松症(aHRs,1.737;95% CI,1.214-2.485;p = 0.003)和营养不良(aHRs,1.581;95% CI,1.094-2.284;p = 0.015)与全因死亡率相关:结论:根据 AWGC 标准评估,四分之三的老年心房颤动患者存在恶病质,但恶病质与较差的预后无关。由于新的 AWGC 恶病质标准将导致更大比例的患者被诊断为恶病质,因此需要进一步考虑在临床实践中实施该标准:UMIN-CTR 唯一标识符:UMIN000023929.
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引用次数: 0
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Journal of Cachexia, Sarcopenia and Muscle
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