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Regional Photoimmobilized Growth Factors-Polystyrene Scaffold Induced Reverted Senescence BMSCs for Bone Regeneration 区域光固定化生长因子-聚苯乙烯支架诱导恢复衰老骨髓间充质干细胞骨再生
Pub Date : 2019-01-01 DOI: 10.2139/ssrn.3441969
Ling-Kun Zhang, Wu-Ya Chen, Huimin Wang, Yuxuan Jiao, Yunzhi Tang, Yi Zhang, Yanqing Guan
Bone diseases such as bone cancer, osteomalacia, osteoporosis, and osteomyelitis represent major illnesses that threaten the health of humans. Bone transplantations often needs restoration to the damaged bone. However, autografts still have some limitations. This study aimed to provide a region-specific immobilization of growth factors (GFs) in the scaffolds, which in turn can help in differentiating of BMSCs into three different cells in the same scaffold. The exposure tert-butyl hydroperoxide (t-BHP) aging model of BMSCs was reverted in vitro by using CNT-IGF-PCL-PLA scaffolds. Polystyrene (PS) region-specific immobilized GFs was then used by interference and diffraction of ultraviolet (UV). In addition, the reverted BMSCs were regionally differentiation into three kinds of cells. In vivo, GFs-PS scaffolds accelerate bone healing in injured Sprague-Dawley (SD) rats after treatment for 21 days. The CNT-IGF-PCL-PLA scaffolds demonstrated good biological and chemical properties, and the external experiments showed significant resistance of senescence in BMSC. Meanwhile, GFs-PS effectively promoted the differentiation of reverted BMSCs in the designated area on day 21. These results suggested that GFs are localized by co-immobilization on PS for the first time by optical interference and diffraction of UV light, which isconsidered as a short-time, low cost, and simple operation method.
骨癌、骨软化症、骨质疏松症和骨髓炎等骨病是威胁人类健康的主要疾病。骨移植通常需要修复受损的骨。然而,自体移植物仍有一些局限性。本研究旨在提供生长因子(GFs)在支架中的区域特异性固定,从而有助于BMSCs在同一支架中分化为三种不同的细胞。采用CNT-IGF-PCL-PLA支架体外修复骨髓间充质干细胞暴露性过氧化叔丁基(t-BHP)老化模型。然后通过干涉和紫外衍射对聚苯乙烯(PS)区域特异性固定化GFs进行了研究。此外,修复的骨髓间充质干细胞被区域分化为3种细胞。在体内,GFs-PS支架在治疗21天后加速了SD大鼠的骨愈合。cnts - igf - pcl - pla支架具有良好的生物学和化学性能,体外实验显示其在骨髓间充质干细胞中具有明显的抗衰老能力。同时,GFs-PS在第21天有效促进了指定区域内恢复的骨髓间充质干细胞的分化。这些结果表明,利用光干涉和紫外光衍射首次将GFs共固定在PS上,是一种时间短、成本低、操作简单的方法。
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引用次数: 0
In Situ Transmission Electron Microscopy Investigation of Continuous Precipitation of Ni 3Mo in a Superalloy Formed by Direct Current Magnetron Sputtering 原位透射电镜研究直流磁控溅射形成的高温合金中Ni 3Mo的连续析出
Pub Date : 2019-01-01 DOI: 10.2139/ssrn.3414707
M. G. Emigh, J. Krogstad
In Situ heating experiments explore a correlation between hexagonal close-packed (HCP) domains in sputter-deposited Ni-25Mo-8Cr films and the precipitation of HCP-type structures (Ni3Mo). Dynamic observation of phase evolution in diffraction mode confirms that precipitation behavior in these defect-dense thin films is not merely kinetically accelerated; instead, the pathway is fundamentally altered. Short-range ordering (SRO) behavior was observed upon reaching 650ºC. SRO has been documented as part of the face-centered cubic (FCC)-precipitation pathway, but has not previously been reported for HCP-based precipitates. This effort provides evidence for continuous ordering of HCP-based precipitates from SRO domains in a mixed FCC-HCP metallic material.
原位加热实验探讨了溅射沉积Ni-25Mo-8Cr薄膜中六方紧密堆积(HCP)畴与HCP型结构(Ni3Mo)析出之间的关系。在衍射模式下对相演化的动态观察证实了这些缺陷致密薄膜的析出行为不仅仅是动力学加速;相反,这一途径从根本上改变了。在达到650℃时观察到短程有序(SRO)行为。SRO已经被记录为面心立方(FCC)沉淀途径的一部分,但以前没有报道过基于hcp的沉淀。这项工作为FCC-HCP混合金属材料中基于hcp的沉淀从SRO域连续有序提供了证据。
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引用次数: 0
Towards Excellent High-Temperature Cycling Performance of Fine LiNi 0.88Co 0.09Al 0.03O 2 Cathode Material for Lithium-Ion Battery Via a Solvothermal Routine 锂离子电池正极材料LiNi 0.88Co 0.09Al 0.030 o2高温循环性能研究
Pub Date : 2019-01-01 DOI: 10.2139/ssrn.3427504
Guolin Cao, Jie Zhu, Yun-jiao Li, Yuan Zhou, Zhuomin Jin, Bin Xu, Chunxi Hai, Jinbo Zeng, J. Zhai, Yongxiang Chen, Jia Guo
Thus far, the chemical co-precipitation has been most commonly adopted to synthesize (Nickel-Cobalt-Aluminum) NCA cathode materials specific for lithium-ion batteries (LIBs). However, co-precipitation of Ni2+, Co2+ and Al3+ is hard to control for their large difference in solubility product constant. To develop a new synthetic route of NCA, the fast solvothermal process-assisted high temperature solid-state reaction was firstly performed to synthesize well-constructed fine NCA cathode materials. The as-synthesized LiNi0.88Co0.09Al0.03O2 using a solvothermal method exhibits excellent high-temperature cycling performance. The study suggests that the fast solvothermal process-assisted high temperature solid-state method is a candidate for synthesizing the high-performance NCA cathode material.
迄今为止,化学共沉淀法是合成锂离子电池(LIBs)专用(镍钴铝)NCA正极材料最常用的方法。然而,由于Ni2+、Co2+和Al3+的溶解度乘积常数差异较大,导致它们的共析出难以控制。为了开发新的NCA合成途径,首次采用快速溶剂热法辅助高温固相反应合成了结构良好的精细NCA正极材料。采用溶剂热法合成的lini0.88 co0.09 al0.030 o2具有优异的高温循环性能。研究表明,快速溶剂热法辅助高温固相法是合成高性能NCA正极材料的可行方法。
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引用次数: 0
Realizing Bright Blue-Red Color-Tunable Emissions from Gd 2GeO 5:Bi 3+Eu3+ Phosphors Through Energy Transfer Toward Light-Emitting Diodes 通过向发光二极管的能量转移实现Gd 2geo5: bi3 +Eu3+荧光粉的明亮蓝红色可调谐发射
Pub Date : 2019-01-01 DOI: 10.2139/ssrn.3454932
Qi Sun, T. Sakthivel, Shaoying Wang, Liangling Sun, Jia Wen Liang, Xiaoyong Huang
Novel Bi3+/Eu3+ ions co-doped Gd2GeO5 (GGO) phosphors were prepared by a high-temperature solid-state reaction method. X-ray diffraction, photoluminescence, and CIE chromaticity coordinates were applied to analyze the as-obtained phosphors. The as-prepared GGO:Bi3+,Eu3+ phosphors showed color-tunable emissions from blue (Bi3+) to red (Eu3+) with increasing the Eu3+ doping concentration via a high-efficiency energy transfer process. Moreover, the mechanism of energy transfer from Bi3+ to Eu3+ ions was the dipole-quadrupole interaction. All these meaningful results demonstrated that blue-red color-tunable GGO:Bi3+,Eu3+ phosphors have potential applications in white light-emitting diodes (LEDs) and plant growth LEDs.
采用高温固相反应法制备了新型Bi3+/Eu3+离子共掺杂Gd2GeO5 (GGO)荧光粉。采用x射线衍射、光致发光和CIE色度坐标对所得荧光粉进行了分析。制备的GGO:Bi3+,Eu3+荧光粉通过高效的能量转移过程,随着Eu3+掺杂浓度的增加,呈现出从蓝色(Bi3+)到红色(Eu3+)的颜色可调特性。此外,Bi3+离子向Eu3+离子的能量传递机制是偶极-四极相互作用。所有这些有意义的结果表明,蓝红色可调的GGO:Bi3+,Eu3+荧光粉在白光发光二极管(led)和植物生长led中具有潜在的应用前景。
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引用次数: 1
A Further Improvement in the Room-Temperature Formability of Az31-0.5Ca Magnesium Alloy Sheets by Pre-Stretching 预拉伸对Az31-0.5Ca镁合金板材室温成形性能的进一步改善
Pub Date : 2019-01-01 DOI: 10.2139/ssrn.3474450
U. M. Chaudry, K. Hamad
In the present study, pre-stretching experiments were carried out on AZ31-0.5Ca magnesium alloy to alter the microstructure and texture for enhancing its room-temperature stretch formability. The alloy samples were pre-stretched to 5%, 10% and finally to 15% and its effects on the structure, properties and performance were analyzed. Compared with the as-received alloy, the room-temperature stretch formability of the 5%-stretched sample was found to be improved by 15%. This was mainly attributed to the enhanced strain hardening capability, which in turn, is related to the evolution of tension twins and the less homogeneous microstructure of this sample.
本研究通过对AZ31-0.5Ca镁合金进行预拉伸实验,改变其组织和织构,提高其室温拉伸成形性能。分别将合金试样预拉伸至5%、10%和15%,分析预拉伸对合金组织、性能和性能的影响。与原位合金相比,拉伸5%试样的室温拉伸成形性能提高了15%。这主要是由于应变硬化能力的增强,而应变硬化能力的增强又与拉伸孪晶的演变和该样品的不均匀组织有关。
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引用次数: 0
Lithium Based Grease with Additives as an Alternative Lubricant for Conventionally Oil Lubricated Journal Bearings of Sugarcane Crushing Mills 含添加剂的锂基润滑脂作为甘蔗压榨机常规油润滑滑动轴承的替代润滑剂
Pub Date : 2018-12-13 DOI: 10.2139/ssrn.3328445
P. Nagare, G. J. Vikhe Patil, H. Kudal
The purpose of this work was to examine the tribological issues related to failure of heavily loaded split journal bearings sugarcane crushing mills. . It was also identified that hydrodynamic fluid film was not formed due to low speed of journal. Regime of lubrication for such journal bearings is thin film lubrication. In such situations journal and bearing surface has physical contact and adhesive or abrasive wear may occur. For such situations grease lubrication can be adopted for journal bearings. Suitability of Lithium Grease with additives as lubricant for sugarcane crushing mills is verified using four ball tester machine.
这项工作的目的是研究与甘蔗压榨机重载分裂轴颈轴承失效有关的摩擦学问题。同时,由于轴颈转速较低,未形成流体动力膜。这种轴颈轴承的润滑机制是薄膜润滑。在这种情况下,轴颈和轴承表面有物理接触,可能发生粘着或磨料磨损。在这种情况下,轴颈轴承可采用润滑脂润滑。用四球试验机验证了含添加剂锂脂作为甘蔗压榨机润滑剂的适用性。
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引用次数: 0
Synthesis and Study of Bio-Lubricant from Jatropha Vegetable Oil 麻疯树植物油生物润滑油的合成与研究
Pub Date : 2018-12-13 DOI: 10.2139/ssrn.3328410
G. Ramesh, T. Nagaraju, Sathvik Chowgi
Bio-lubricant is synthesized using non-edible Jatropha vegetable oil. The chemical modification through double transesterification using sodium methoxide is done to remove fatty acid and Benzoic acid is added as additive. The additive is added to the double transesterified Jatropha oil in the ratio of 0%, 1%, 2% and 3% by weight. Then the physical and tribological characteristics such as flash point, kinematic viscosity, wear and frictional characteristics of synthesized bio-lubricant are experimentally studied. From the experimental results, the double transesterified Jatropha oil with 2 wt% of Benzoic acid additive is shown to provide a good anti-wear property with less coefficient of friction as compared to mineral oils SAE5W30 and SAE10W30. Thus, the global demand for petroleum based lubricants is found to be reduced by non-edible Jatropha oil through proper chemical modification and addition of benzoic acid additive in proper wt%.
生物润滑油是用不可食用的麻疯树植物油合成的。采用甲氧基钠双酯交换法进行化学改性,去除脂肪酸,并加入苯甲酸作为添加剂。在双酯交换麻风树油中按重量0%、1%、2%、3%的比例加入添加剂。然后对合成的生物润滑油的闪点、运动粘度、磨损和摩擦等物理和摩擦学特性进行了实验研究。实验结果表明,与矿物油SAE5W30和SAE10W30相比,苯甲酸添加量为2 wt%的双酯交换麻风树油具有较好的抗磨性能,摩擦系数较小。因此,通过对非食用麻风树油进行适当的化学改性和添加适当wt%的苯甲酸添加剂,可以减少全球对石油基润滑油的需求。
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引用次数: 2
Nanoscratch Property of Self-lubricating Ti/MoS2 Nanocoating at Nano-scale Level 纳米级自润滑Ti/MoS2纳米涂层的纳米划痕性能
Pub Date : 2018-12-13 DOI: 10.2139/ssrn.3321096
Summèra Banday, M. F. Wani, M. Mir, J. Singh, S. Mushtaq, Jebran Khan, S. S. Saleem
Nanoscratch test was performed on self-lubricating Ti/MoS2 coating of 99.79 nm thickness prepared by pulse laser deposited technique on Al-13Si substrate. The surface morphology and surface elemental analysis of Ti/MoS2 were studied using Scanning electron microscope integrated with Energy dispersive X-ray spectroscopy. The structural analysis of Ti/MoS2 coating was conducted using X-ray diffraction and Raman spectroscopy. Nanoscratch tests were carried out at low load of 250-1250 µN to examine the deformation and failure behaviour of the coating/substrate system. The results indicate that Ti/MoS2 coating show better adhesion strength at low loads. Also, in-situ scanning probe microscope images of Ti/MoS2 coating shows plastic flow of coating with no debris and cracks on the surface. Thus, the mode of wear mechanism is mainly ductile and abrasive.
采用脉冲激光沉积技术在Al-13Si衬底上制备了厚度为99.79 nm的自润滑Ti/MoS2涂层,并进行了纳米划痕实验。利用扫描电镜结合能量色散x射线能谱技术研究了Ti/MoS2的表面形貌和表面元素分析。利用x射线衍射和拉曼光谱对Ti/MoS2涂层进行了结构分析。在250-1250µN的低载荷下进行纳米划伤试验,以检查涂层/基体系统的变形和破坏行为。结果表明,Ti/MoS2涂层在低负荷下具有较好的附着强度。Ti/MoS2涂层的原位扫描探针图像显示涂层的塑性流动,表面无碎屑和裂纹。因此,磨损机制的模式主要是韧性和磨料。
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引用次数: 2
A Comparative Experimental Investigation on Defects in Rolling Contact Bearing by Vibration Analysis Technique Using FTT 基于FTT振动分析技术的滚动接触轴承缺陷对比试验研究
Pub Date : 2018-12-13 DOI: 10.2139/ssrn.3355554
Sagar Bhingare, Vinay Y. Jadhav, Tejas Jadhav, Pratik Shendge, Shubham Lidhade, V. Phalle
Rolling contact bearing defects are analyzed in this paper experimentally. RCB plays a major role in rotating parts under high speeds and loads and are widely used in many machinery components. The defect or malfunctioning in this rolling elements leads to severe consequences in productivity and also costly downtime. So if we could monitor these rolling elements and could predict the severity of defect prior to they actually happen much advantage could be gain than after failure of rolling elements. Therefore vibration monitoring was used to detect various defects. This paper also shows compatibility of Vibration analysis technique for detecting the distributed defects in rolling elements. Experimental analysis is done on roller bearing with different load condition (1kg ,2kg,3kg) and without load condition with respective to speed of shaft in rpm (1000,2000,3000) . Then the comparison is carried out between healthy and defective bearings on the basis of results obtained from FFT analysis. The results extracted from experiments are presented and explained in detail.
本文对滚动接触轴承缺陷进行了实验分析。RCB在高速和高负荷下的旋转部件中起着重要作用,广泛应用于许多机械部件中。这种滚动元件的缺陷或故障会导致生产力的严重后果,也会导致昂贵的停机时间。因此,如果我们能够监测这些滚动元件,并在它们实际发生之前预测缺陷的严重程度,将比滚动元件失效后获得更多的优势。因此,振动监测用于检测各种缺陷。本文还说明了振动分析技术在检测滚动构件分布缺陷中的适用性。分别对滚子轴承在不同载荷条件下(1kg、2kg、3kg)和无载荷条件下的轴转速(1000、2000、3000)进行了实验分析。然后在FFT分析结果的基础上对健康轴承和缺陷轴承进行了比较。并对实验结果进行了详细说明。
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引用次数: 0
Physiochemical Properties of Hexagonal Boron Nitride Blended Coconut Oil 六方氮化硼混合椰子油的理化性质
Pub Date : 2018-12-13 DOI: 10.2139/ssrn.3321035
J. Katiyar, S. Bhaumik, A. Ashok, Anuj K. Sharma
Lubrication plays a vital role in engineering. Now a day’s reduction in friction is a major and ongoing task for researchers. Few researches are focussing on various Nano additives that lower value of friction and hence wear can be reduced. Therefore, the main objective of this paper is to determine the anti-wear characteristics of the lubricant along with extreme pressure point. Further, also determine the physiochemical properties. In this research coconut oil is used as a lubricant and hexagonal boron nitride (h-BN) is used as friction modifier. The ultrasonic homogenizer was used for mixing of friction modifier with lubricant. Further, four ball test rig was used to obtain the extreme pressure, coefficient of friction and wear scar. After test, balls were characterized using 3D optical profilometer and scanning electron microscopy. From the results, it is observed that 2.5 wt % h-BN with coconut oil gives low coefficient of friction, high extreme pressure with moderate wear scar. Finally, Comparison with commercial mineral oil (CMO), the newly developed additive oil combination is having excellent properties and it can be used as a substitute as it is biodegradable, nontoxic, easily manufactured and environment friendly.
润滑在工程中起着至关重要的作用。现在,减少一天的摩擦是研究人员的一个主要和持续的任务。各种纳米添加剂可以降低摩擦值,从而减少磨损,目前的研究很少。因此,本文的主要目的是确定润滑油沿极限压力点的抗磨特性。进一步,还要确定理化性质。本研究以椰子油为润滑剂,六方氮化硼(h-BN)为摩擦改进剂。采用超声均质机对摩擦改性剂与润滑剂进行了混合。在此基础上,利用四球试验台进行了极限压力、摩擦系数和磨损痕试验。测试后,用三维光学轮廓仪和扫描电镜对球进行了表征。结果表明,在椰子油中掺入2.5 wt %的h-BN后,摩擦系数低,极压高,磨痕适中。最后,与商品矿物油(CMO)相比,新开发的添加剂油组合具有可生物降解、无毒、易于制造和环境友好等优点,可作为矿物油的替代品。
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引用次数: 1
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Materials Processing & Manufacturing eJournal
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