Minerva stomatologica最新文献

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Background: Quantitative assessment of bleeding in dental extractions is rarely reported in the literature. The assessment of bleeding might provide additional evidence to predict and minimize postoperative outcomes. The aim of this study was to evaluate the pattern of bleeding in individuals taking direct oral anticoagulants (DOACs) submitted to dental extractions.

Methods: Intraoperative bleeding was evaluated by using total collected bleeding corrected by absorbance reading (dental bleeding score). To monitoring bleeding episodes from the day of surgery, this cohort was followed up until the seventh postoperative day.

Results: Forty-five procedures were performed in three comparative groups, patients under DOACs, individuals taking vitamin K antagonists (VKAs) and without anticoagulant therapy. No bleeding events were observed in procedures carried out in individuals of the DOAC group. Additional hemostatic measures were required in two procedures in the VKA group and one in the non-anticoagulated group. The dental bleeding scores obtained for the DOAC and VKA groups were similar.

Conclusions: Our data suggest that the DOAC therapy did not result in increased bleeding outcomes in this sample.

Background: Lysyl oxidase (LOX) is a copper amine oxidase which belongs to the LOX multigene family and is normally involved in cross-linking of stromal collagen fibers. LOX expression has been found to be associated with increased episodes of recurrence, metastasis and overall poor prognosis in renal cell carcinomas and melanomas. This study aimed to assess the effects of LOX on the prognosis of oral squamous cell carcinoma (OSCC), which is one of the most common cancers in India.

Methods: The immunohistochemical expression of lysyl oxidase using LOX2 primary antibody was assessed at the tumor proper, invasive tumor front and peritumoral stroma in tissue sections from 40 cases of histologically proven OSCC.

Results: LOX expression was elevated in OSCC patients who had lymph node metastasis and in those who died of disease. No significant variation was seen with histological grade.

Conclusions: LOX has a 'pro-neoplastic' effect as it modulates the host stroma to favor increasing tumor mass and worsening prognosis. Increased expression of LOX causes increased collagen fiber cross-linkage that stiffens the stromal matrix. This increases compressive stresses contributing to tissue hypoxia that elevates Rho GTPase-dependent cytoskeletal tension leading to erratic tumor cell morphogenesis that in turn confers motility to these cells resulting in metastasis. Inhibitors of LOX can potentially down-regulate LOX levels in the tumor micro-environment by controlling tissue hypoxia and curtailing the production of hypoxic LOX molecules.

Background: Currently in dentistry, scientific research has been conducted in the study of dental implants. Being able to optimize dental implants, in all its mechanical and biological components, is the main objective of the research. The purpose of this article was to evaluate the structure and the molecular features of dental implant titanium alloy.

Methods: Two different internal hexagonal connection systems belonging to FDS76^® have been used as sample. Beyond the literature search, fixture and abutment surface through an X-Ray Fluorescence (XRF) method have been analyzed.

Results: The surfaces have achieved an excellent level of quality and low impurity, according to commercial pure titanium alloy.

Conclusions: This information will surely bring useful information to evaluate the quality of this type of alloy and possibly improve its features.

Background: To correlate fluorescence-based camera (FC), visual inspection (ICDAS-II) and radiographic examination X-rays bitewings (BW) to the extent of caries after excavation.

Methods: The occlusal sites of 20 permanent first and second molars in 14 young adolescents (12±2 years old) were examined at 1^st Observation Unit of Department of Oral and Maxillofacial Sciences, "Sapienza" University of Rome. All the enrolled patients were asked to provide with X-rays bitewing of the studied teeth. The assessment of ICDAS-II and FC was performed by a trained operator. Then a second blind operator removed the carious lesion and evaluated the cavity extent (depth, width, length) after caries removal with a calibrated probe. To correlate FC measurements with bitewing sensitivity, 10 dentists evaluated the presence/absence of caries on the X-rays.

Results: All the occlusal sites assessed by fluorescence camera, ranged from 1.7 to 2, indicating in all cases deep enamel lesions with possible extent to dentine with a mean of 1.7±0. In accordance, visual inspection by ICDAS-II showed scores of 3 and 4. By contrast, the radiographic documentation, i.e. bitewing X-rays, was evaluated in only 6 cases as presence of caries. The extent of the cavities was determined by three consecutive measurements: depth, width and length, with a mean of 3.5+1.73, 2.8+1.07 and 3.2+1.64 mm respectively. These results confirmed the agreement between FC and ICDAS-II for diagnosis of cavities with extent to enamel and dentine, while showed the low sensitivity of bitewings X-rays, in accordance with the existing evidence in Literature. Moreover, the results of this study for the first time provide information about the cavity extent after caries removal for the occlusal sites with ICDAS-II 3 and 4 scores and FC≥1.7.

Conclusions: X-rays evaluation showed diagnostic accuracy in 6% of the sample. VistaCam measurement of 1.7 was correlated to a cavity with 3.5, 2.8 and 3.2 mm of depth, width and length.

Background: During dental implants placement and bone augmentation procedures, it is important to determine the presence and location of mandibular canal anatomical variation in order to avoid injuries to inferior alveolar bundle. This study aimed to describe the prevalence and configuration of mandibular canal branching in the posterior region of the mandible using cone beam computed tomography (CBCT).

Methods: The interpretation of the images was conducted according to the presence, classification and location of the mandibular canal. Horizontal and vertical distances from mandibular canal in the ramus region to the molar region was recorded. CBCT images of 751 patients, 486 women (64.7%) and 265 men (35.3%), with a mean age of 54.57 (±13.23; 14-93) years, were interpreted by one calibrated examiner.

Results: Out of 1502 hemi-mandibles images, mandibular canal variations were observed in 130 (8.6%). Sixty-four (49.2%) mandibular canal variations were identified on the right side and 66 (50.8%) on the left side. The mean distances between superior cortical of the mandibular canal and the base of mandible, buccal cortical of mandibular canal and buccal cortical bone, and superior cortical of mandibular canal and alveolar ridge were 12.16 mm (±2.68), 4.17 mm (±1.30), and 12.97mm (±4.01), respectively. Type I mandibular canal variation was the most frequent (68; 52.2%), followed by type III (34; 26.1%).

Conclusions: Prevalence of mandibular canal variations was 8.6%, type I was the most common and its direction showed proximity with lingual surface in the second molar region.

Background: The patients' request for treatment with clear aligners is constantly increasing. The aligners permit to the clinicians a valid way to solve a lot of orthodontic cases but the patients' compliance and the clinicians' capabilities and knowledge of the technique is fundamental for the outcome.

Methods: Seventy-two digital models of 18 consecutive patients treated with Invisalign and Smart Track aligners for 14 weeks were analyzed. The operator positioned 24 points on each model and were obtained the values of arch depth and perimeter of arch before and after the treatment. The variations of measurement were calculated with t student test.

Results: A decrease of arch depth and perimeter was found from t0 to t1 and the most relevant difference was observed in the upper arch depth with a decrease of 1.3 mm and in the upper arch perimeter with a difference of 1.1 mm.

Conclusions: There was always a decrease of the values of arch depth and arch perimeter at the end of the treatment, especially in the upper arch. These changes must be considered by the clinicians to perform a better treatment to obtain the most predictable results and a patient's higher satisfaction.

Background: One to 6 months after implant placement is a critical time/period responsible for crestal bone loss that may affect implant osseointegration. The study aims to explore the effectiveness of provisional adhesive Maryland-bridge (AMB) applied to prevent marginal bone level (MBL) around implants placed in edentulous crestal bone in posterior area during osseointegration period.

Methods: Healthy, non-smoker patients (N.=18) were included in the study. Titanium implants were placed nonsubmerged (i.e. tissue-level) with cover screws at gingival level in edentulous crestal bone with flapless technique. Nine patients randomly received an AMB, while 9 patients did not receive any AMB. Each AMB remained in place for 3 months and removed before impression. After 3 months abutments were applied, and provisional resin crowns cemented and definitive metal-ceramic crowns were cemented after 2-3 months. Periapical Rx were taken using paralleling technique before and after implant insertion, at 1, 3 months (pre-loading time) and after 6 months (post-loading time). MBL was evaluated in double-blind on scanned periapical radiographs and assessed at mesial and distal side of implants (M-MBL and D-MBL). Area of bone loss on mesial and distal side of implants (Area-M and Area-D) and Cervical Enamel Junction migration of mesial and distal adjacent teeth were also measured (CEJ-M and CEJ-D). Linear regression models were fitted to evaluate the existence of any significant difference.

Results: Two drop-out was observed in AMB group. A total of 16 patients completed the study. After 6 months, all implants were safe and free from complications. AMB group showed the most stable MBL at 1-6 months, statistically different from non-AMB and resulted in a reduced crestal bone loss from baseline compared to Non AMB group. Area-M and Area-D were not statistically different between the groups. CEJ-M and CEJ-D were stable in both groups.

Conclusions: The use of Adhesive Maryland Bridge to protect non-submerged post-extractive implants is a safe procedure that prevents bone loss around implants and preserve the 3D architecture of crestal bone ridge.