Pub Date : 2026-01-29DOI: 10.1038/s41929-026-01497-9
Qingyun Dan, Yan Chiu, Namil Lee, Jose Henrique Pereira, Behzad Rad, Xixi Zhao, Kai Deng, Yiou Rong, Chunjun Zhan, Yan Chen, Seokjung Cheong, Chenyi Li, Jennifer W. Gin, Andria Rodrigues, Trent R. Northen, Tyler W. H. Backman, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Jay D. Keasling
{"title":"Author Correction: A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids","authors":"Qingyun Dan, Yan Chiu, Namil Lee, Jose Henrique Pereira, Behzad Rad, Xixi Zhao, Kai Deng, Yiou Rong, Chunjun Zhan, Yan Chen, Seokjung Cheong, Chenyi Li, Jennifer W. Gin, Andria Rodrigues, Trent R. Northen, Tyler W. H. Backman, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Jay D. Keasling","doi":"10.1038/s41929-026-01497-9","DOIUrl":"https://doi.org/10.1038/s41929-026-01497-9","url":null,"abstract":"","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"38 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1038/s41929-025-01475-7
Tengfei Pang, Yangjinxiu Zhou, Yuzhou Wu
New-to-nature photometabolisms are highly intriguing for manufacturing but difficult to achieve. Now, Escherichia coli engineering integrates flavin-based photobiocatalysis with natural enzymatic reactions, achieving efficient semi- and complete photobiosynthesis of diverse unnatural products, demonstrating scalable manufacturing in bioreactors.
{"title":"Light-driven metabolic makeover","authors":"Tengfei Pang, Yangjinxiu Zhou, Yuzhou Wu","doi":"10.1038/s41929-025-01475-7","DOIUrl":"10.1038/s41929-025-01475-7","url":null,"abstract":"New-to-nature photometabolisms are highly intriguing for manufacturing but difficult to achieve. Now, Escherichia coli engineering integrates flavin-based photobiocatalysis with natural enzymatic reactions, achieving efficient semi- and complete photobiosynthesis of diverse unnatural products, demonstrating scalable manufacturing in bioreactors.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 1","pages":"5-6"},"PeriodicalIF":44.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1038/s41929-026-01483-1
Jan-Stefan Voeller
{"title":"Cascade control pays dividends","authors":"Jan-Stefan Voeller","doi":"10.1038/s41929-026-01483-1","DOIUrl":"10.1038/s41929-026-01483-1","url":null,"abstract":"","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 1","pages":"2-2"},"PeriodicalIF":44.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1038/s41929-026-01485-z
This Editorial highlights some potential pitfalls occasionally encountered within point-to-point response letters to the reviewers.
这篇社论强调了在给审稿人的点对点回复信中偶尔遇到的一些潜在陷阱。
{"title":"Straight to the point-to-point response","authors":"","doi":"10.1038/s41929-026-01485-z","DOIUrl":"10.1038/s41929-026-01485-z","url":null,"abstract":"This Editorial highlights some potential pitfalls occasionally encountered within point-to-point response letters to the reviewers.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 1","pages":"1-1"},"PeriodicalIF":44.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41929-026-01485-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1038/s41929-025-01466-8
Mark Mba Wright
A cobalt-doped RuO2 catalyst enables proton-exchange-membrane (PEM) electrolysers to operate on inexpensive reverse-osmosis water for thousands of hours by blocking chloride and cation impurities. Dual interfacial shielding preserves membrane conductivity, suppresses chlorine evolution and minimizes metal dissolution. This strategy lowers capital and operating costs while maintaining high current densities, advancing practical low-purity-water hydrogen production.
{"title":"Shielding PEM electrolysers from real-world water","authors":"Mark Mba Wright","doi":"10.1038/s41929-025-01466-8","DOIUrl":"10.1038/s41929-025-01466-8","url":null,"abstract":"A cobalt-doped RuO2 catalyst enables proton-exchange-membrane (PEM) electrolysers to operate on inexpensive reverse-osmosis water for thousands of hours by blocking chloride and cation impurities. Dual interfacial shielding preserves membrane conductivity, suppresses chlorine evolution and minimizes metal dissolution. This strategy lowers capital and operating costs while maintaining high current densities, advancing practical low-purity-water hydrogen production.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 1","pages":"7-8"},"PeriodicalIF":44.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methane, a potent greenhouse gas and a chemically inert molecule, presents a major challenge for catalytic conversion. Existing methods are energy-intensive, while photocatalysis offers a promising solar-driven alternative; yet, its efficiency and selectivity are often hampered by uncontrolled radical reactivity and inefficient charge separation. Here we have developed a full-solar-spectrum photocatalyst by constructing a Schottky heterojunction with Pd deposited on Co3O4 derived from a metal–organic framework. The narrow bandgap and black colouration of Co3O4 enable broad solar absorption, while its tailored band structure minimizes overoxidation and undesired by-products by suppressing reactive species, including O2•−, ·OH and ·OOH. The work function difference between Pd and Co3O4 establishes an interfacial electric field that promotes directional carrier migration and reduces recombination. This design achieves efficient solar utilization, precise radical regulation and robust charge separation, delivering a C2H6 production rate from CH4 of 16.1 mmol per gram catalyst per hour with ~96.2% selectivity under mild conditions. The success of photocatalytic coupling of CH4 has been limited by the low solar absorption of wide-bandgap semiconductors and the uncontrolled oxidation caused by radical oxygen species. Here a Pd/Co3O4 heterojunction derived from a metal–organic framework demonstrates the selective conversion of CH4 to C2H6 by less reactive oxygen species under full-solar-spectrum irradiation.
{"title":"Co3O4 as full-solar-spectrum photocatalyst for selective methane conversion through reactive oxygen species control","authors":"Feiyan Xu, Luoxuan Zheng, Jianjun Zhang, Ying He, Heng Cao, Xusheng Zheng, Hermenegildo García, Jiaguo Yu","doi":"10.1038/s41929-025-01471-x","DOIUrl":"10.1038/s41929-025-01471-x","url":null,"abstract":"Methane, a potent greenhouse gas and a chemically inert molecule, presents a major challenge for catalytic conversion. Existing methods are energy-intensive, while photocatalysis offers a promising solar-driven alternative; yet, its efficiency and selectivity are often hampered by uncontrolled radical reactivity and inefficient charge separation. Here we have developed a full-solar-spectrum photocatalyst by constructing a Schottky heterojunction with Pd deposited on Co3O4 derived from a metal–organic framework. The narrow bandgap and black colouration of Co3O4 enable broad solar absorption, while its tailored band structure minimizes overoxidation and undesired by-products by suppressing reactive species, including O2•−, ·OH and ·OOH. The work function difference between Pd and Co3O4 establishes an interfacial electric field that promotes directional carrier migration and reduces recombination. This design achieves efficient solar utilization, precise radical regulation and robust charge separation, delivering a C2H6 production rate from CH4 of 16.1 mmol per gram catalyst per hour with ~96.2% selectivity under mild conditions. The success of photocatalytic coupling of CH4 has been limited by the low solar absorption of wide-bandgap semiconductors and the uncontrolled oxidation caused by radical oxygen species. Here a Pd/Co3O4 heterojunction derived from a metal–organic framework demonstrates the selective conversion of CH4 to C2H6 by less reactive oxygen species under full-solar-spectrum irradiation.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 1","pages":"73-86"},"PeriodicalIF":44.6,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Photobiocatalysis provides a powerful strategy for integrating light and biological catalysts to drive abiological transformations. However, its scalability is hindered by high enzyme loading, reliance on costly cofactors and instability under radical-generating conditions. Here we report the integration of light-driven enzymatic reactions into the cellular metabolism of Escherichia coli, bridging flavin-based photobiocatalysis with biosynthesis. Using synthetic biology strategies, we engineered microbial cells to continuously produce olefin substrates and ene-reductase while regenerating cofactors directly from glucose. By externally supplying radical precursors or introducing synthetic pathways for their in situ production, we enabled fermentation-based microbial photobiosynthesis, achieving high titres and demonstrating feasibility for scale-up in a bioreactor. This approach extends photobiocatalysis from in vitro applications to in vivo semi- and complete biosynthesis, revealing its full potential for integrating light-driven reactions into cellular metabolism. Light-driven enzymatic catalysis has enabled important abiological transformations in vitro. Now a cellular ene-reductase photoenzyme is integrated with a de novo-designed olefin biosynthetic pathway for photoinduced hydroalkylation, hydroamination and hydrosulfonylation reactions within cells.
{"title":"Harnessing photoenzymatic reactions for unnatural biosynthesis in microorganisms","authors":"Yujie Yuan, Maolin Li, Wesley Harrison, Zhengyi Zhang, Huimin Zhao","doi":"10.1038/s41929-025-01470-y","DOIUrl":"10.1038/s41929-025-01470-y","url":null,"abstract":"Photobiocatalysis provides a powerful strategy for integrating light and biological catalysts to drive abiological transformations. However, its scalability is hindered by high enzyme loading, reliance on costly cofactors and instability under radical-generating conditions. Here we report the integration of light-driven enzymatic reactions into the cellular metabolism of Escherichia coli, bridging flavin-based photobiocatalysis with biosynthesis. Using synthetic biology strategies, we engineered microbial cells to continuously produce olefin substrates and ene-reductase while regenerating cofactors directly from glucose. By externally supplying radical precursors or introducing synthetic pathways for their in situ production, we enabled fermentation-based microbial photobiosynthesis, achieving high titres and demonstrating feasibility for scale-up in a bioreactor. This approach extends photobiocatalysis from in vitro applications to in vivo semi- and complete biosynthesis, revealing its full potential for integrating light-driven reactions into cellular metabolism. Light-driven enzymatic catalysis has enabled important abiological transformations in vitro. Now a cellular ene-reductase photoenzyme is integrated with a de novo-designed olefin biosynthetic pathway for photoinduced hydroalkylation, hydroamination and hydrosulfonylation reactions within cells.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"9 1","pages":"62-72"},"PeriodicalIF":44.6,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1038/s41929-025-01473-9
Sagnik Chakrabarti, Ju Byeong Chae, Katy A. Knecht, Nicholas D. Cedron, Toby J. Woods, Liviu M. Mirica
Nickel-catalysed cross-coupling reactions have emerged as a powerful strategy to construct complex molecules. Such reactions generally employ Ni(II) or Ni(0) compounds as precatalysts. Although highly desirable, catalytically competent Ni(I) sources with exchangeable ancillary ligands are lacking. Here we report the synthesis, characterization and catalytic activity of thermally stable dinuclear Ni(I) complexes supported by commercially available isocyanides as a general solution to this problem. Two classes of Ni(I) isocyanide complexes have been developed: coordinatively saturated homoleptic compounds and coordinatively unsaturated Ni(I)-halide compounds. These Ni(I) compounds exhibit rapid ligand substitution and are efficient catalysts in Kumada, Suzuki–Miyaura and Buchwald–Hartwig cross-coupling reactions, suggesting their potential use as either Ni(I) catalysts or precatalysts. In addition, bromide-selective functionalization of polyhalogenated arenes with Grignard reagents is achieved under nickel catalysis. Finally, spectroscopic and mechanistic studies are performed to establish the general use of isocyanides as spectator ligands for cross-coupling reactions, representing an untapped chemical space for reaction discovery.
{"title":"Catalytically competent nickel(I)–isocyanide compounds for cross-coupling reactions","authors":"Sagnik Chakrabarti, Ju Byeong Chae, Katy A. Knecht, Nicholas D. Cedron, Toby J. Woods, Liviu M. Mirica","doi":"10.1038/s41929-025-01473-9","DOIUrl":"https://doi.org/10.1038/s41929-025-01473-9","url":null,"abstract":"Nickel-catalysed cross-coupling reactions have emerged as a powerful strategy to construct complex molecules. Such reactions generally employ Ni(II) or Ni(0) compounds as precatalysts. Although highly desirable, catalytically competent Ni(I) sources with exchangeable ancillary ligands are lacking. Here we report the synthesis, characterization and catalytic activity of thermally stable dinuclear Ni(I) complexes supported by commercially available isocyanides as a general solution to this problem. Two classes of Ni(I) isocyanide complexes have been developed: coordinatively saturated homoleptic compounds and coordinatively unsaturated Ni(I)-halide compounds. These Ni(I) compounds exhibit rapid ligand substitution and are efficient catalysts in Kumada, Suzuki–Miyaura and Buchwald–Hartwig cross-coupling reactions, suggesting their potential use as either Ni(I) catalysts or precatalysts. In addition, bromide-selective functionalization of polyhalogenated arenes with Grignard reagents is achieved under nickel catalysis. Finally, spectroscopic and mechanistic studies are performed to establish the general use of isocyanides as spectator ligands for cross-coupling reactions, representing an untapped chemical space for reaction discovery.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"15 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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