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Movement and cyclic Agree 运动与循环一致
IF 1.3 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-07-29 DOI: 10.1007/s11049-022-09538-1
S. Keine, Bhamati Dash
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引用次数: 2
Negative concord in Russian Sign Language 俄语手语中的否定和谐
IF 1.3 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-07-27 DOI: 10.1007/s11049-022-09546-1
J. Kuhn, Lena Pasalskaya
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引用次数: 0
Perspectival domains in nouns and clauses 名词和分句中的透视域
IF 1.3 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-07-08 DOI: 10.1007/s11049-022-09544-3
John Gluckman
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引用次数: 1
Reflexes of exponent movement in inflectional morphology 屈曲形态中指数运动的反射
IF 1.3 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-06-21 DOI: 10.1007/s11049-022-09543-4
Daniel Gleim, G. Müller, Mariia Privizentseva, S. Tebay
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引用次数: 2
Middle voice as generalized argument suppression 中间音作为广义论证抑制
IF 1.3 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-06-13 DOI: 10.1007/s11049-022-09542-5
J. Beavers, Nyoman Udayana
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引用次数: 0
Improper case 不当的情况下
IF 1.3 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-05-16 DOI: 10.1007/s11049-022-09541-6
Ethan Poole
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引用次数: 2
Layered feet and syllable-integrity violations: The case of Copperbelt Bemba bounded tone spread 分层的脚和音节完整性的侵犯:以铜带-本巴有界音调传播为例
IF 1.3 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-04-21 DOI: 10.1007/s11049-021-09514-1
Jeroen Breteler, R. Kager
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引用次数: 3
Reversibility in specificational copular sentences and pseudoclefts 特定连接句和伪连接句的可逆性
IF 1.3 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-04-07 DOI: 10.1007/s11049-022-09540-7
Martina Martinovic
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引用次数: 1
Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis. 调节性 T 细胞在慢性鼻炎伴鼻息肉病中的作用和功能
IF 3.5 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-03-26 eCollection Date: 2022-01-01 DOI: 10.1155/2022/1144563
Chenyang Lei, Juan Jiang, Yanyan Zhang, Gaoyun Xiong

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis characterized by high edema in the stroma, albumin deposition, and formation of pseudocysts. The pathogenesis of CRSwNP is not yet fully understood. Regulatory T (Treg) cells are a subset of CD4+ T cells that play a suppressive immunoregulatory role in the process of CRSwNP. Recent studies have found that there was a significant reduction in Treg cells in polyp tissues, which leads to the onset of CRSwNP. An imbalance between Th17 and Treg cells can also aggravate inflammation toward the Th2 type. This review focuses on our understanding of the function and role of Treg cells and their regulatory factors and clinical significance in CRSwNP. We also summarize the current drug treatments for CRSwNP with Tregs as the potential therapeutic target, which will provide new ideas for the treatment of CRSwNP in the future.

慢性鼻炎伴鼻息肉(CRSwNP)是慢性鼻炎的一种亚型,其特点是鼻腔基质高度水肿、白蛋白沉积和假性囊肿的形成。CRSwNP 的发病机制尚不完全清楚。调节性 T(Treg)细胞是 CD4+ T 细胞的一个亚群,在 CRSwNP 的发病过程中起到抑制免疫调节的作用。最近的研究发现,息肉组织中的 Treg 细胞明显减少,从而导致 CRSwNP 的发生。Th17 细胞和 Treg 细胞之间的失衡也会使炎症向 Th2 型发展。本综述重点介绍我们对 Treg 细胞的功能和作用及其在 CRSwNP 中的调节因子和临床意义的理解。我们还总结了目前以 Tregs 为潜在治疗靶点的 CRSwNP 药物治疗方法,这将为今后治疗 CRSwNP 提供新的思路。
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引用次数: 0
Relationship of COPD Exacerbation Severity and Frequency on Risks for Future Events and Economic Burden in the Medicare Fee-For-Service Population. 慢性阻塞性肺疾病恶化严重程度和频率与未来事件风险和医疗保险付费服务人群经济负担的关系。
IF 2.8 1区 文学 0 LANGUAGE & LINGUISTICS Pub Date : 2022-03-20 eCollection Date: 2022-01-01 DOI: 10.2147/COPD.S350248
Sanjay Sethi, Barry J Make, Scott B Robinson, Shambhavi Kumar, Michael Pollack, Chad Moretz, Jill Dreyfus, Ann Xi, Dakota Powell, Norbert Feigler

Purpose: To quantify the effects of moderate and/or severe chronic obstructive pulmonary disease (COPD) exacerbations on future exacerbations and healthcare costs in Medicare Fee-For-Service beneficiaries.

Patients and methods: A retrospective cohort study of patients ≥40 years of age, with continuous enrollment from 2015 to 2018, with an index COPD diagnosis defined as first hospitalization, emergency department visit, or first of two outpatient visits (≥30 days apart) in 2015 with a claim for chronic bronchitis, emphysema, or chronic airway obstruction. Patients were stratified by baseline exacerbation categories in year one (YR1) and subsequently evaluated in YR2 and YR3: (A) none; (B) 1 moderate; (C) ≥2 moderate; (D) 1 severe; and (E) ≥2, one being severe. Moderate exacerbations were defined as COPD-related outpatient/ED visits with a corticosteroid/antibiotic claim within ±7 days of the visit and severe exacerbations as hospitalizations with a primary COPD diagnosis. Total all-cause costs for Categories B-E were compared to reference Category A using generalized linear models and inflation adjusted to 2019 dollars.

Results: A total of 1,492,108 patients met study criteria with a mean (±SD) age of 70.9±10.9. In YR1, nearly 40% of patients experienced ≥1 moderate and/or severe exacerbations. Patients having multiple exacerbations, regardless of severity were 2-4 times more likely to experience an exacerbation during YR2 and YR3. Adjusted costs ranged between $24,000 and $26,600 for all categories for YR2 and YR3. Adjusted YR2 costs for Category D and E were $1421 and $1548 higher than those without an exacerbation (Category A YR2 $25,084, YR3 $24,282; p<0.0001). The respective YR3 adjusted costs were $2062 and $2117 higher than those without an exacerbation (Category A; p<0.0001), representing an increase of 6-8% and 8-9% for YR2 and YR3.

Conclusion: Medicare patients with recent moderate or severe exacerbations, or at least two exacerbations per year are at significant risk for future exacerbations and incur higher all-cause costs.

目的:量化中度和/或重度慢性阻塞性肺疾病(COPD)加重对医疗保险付费服务受益人未来病情加重和医疗费用的影响:一项回顾性队列研究,研究对象为年龄≥40岁、2015年至2018年连续参保的患者,其慢性阻塞性肺疾病诊断指数定义为2015年首次住院、急诊就诊或两次门诊(间隔≥30天)中的第一次,且索赔为慢性支气管炎、肺气肿或慢性气道阻塞。患者在第一年(YR1)按基线恶化类别进行分层,随后在第二年和第三年进行评估:(A)无;(B)1 次中度;(C)≥2 次中度;(D)1 次重度;以及(E)≥2 次,其中 1 次为重度。中度恶化的定义是与慢性阻塞性肺病相关的门诊/急诊就诊,并在就诊后±7 天内申请皮质类固醇/抗生素治疗;重度恶化的定义是主要诊断为慢性阻塞性肺病的住院治疗。使用广义线性模型将 B-E 类的全因费用总额与参考 A 类进行比较,并将通货膨胀调整为 2019 年的美元:共有 1,492,108 名患者符合研究标准,平均(±SD)年龄为 70.9±10.9。在 YR1 中,近 40% 的患者经历了≥1 次中度和/或重度病情加重。在 YR2 和 YR3 期间,无论病情严重程度如何,出现多次病情加重的患者发生病情加重的几率要高出 2-4 倍。在 YR2 和 YR3 中,所有类别的调整后成本介于 24,000 美元和 26,600 美元之间。D 类和 E 类患者在第二年的调整后费用分别比未发生病情加重的患者高出 1421 美元和 1548 美元(A 类患者第二年为 25084 美元,第三年为 24282 美元;P 结论:近期有中度或重度病情加重或每年至少有两次病情加重的医疗保险患者未来病情加重的风险很大,产生的全因费用也更高。
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引用次数: 0
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Natural Language & Linguistic Theory
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