Pub Date : 2022-03-01DOI: 10.3103/S0891416822010037
M. Kostyaeva, I. Kastyro, T. Yunusov, T. Kolomin, V. Torshin, V. I. Popadyuk, S. Dragunova, S. Shilin, V. K. Kleiman, P. Slominsky, A. Y. Teplov
{"title":"Protein p53 Expression and Dark Neurons in Rat Hippocampus after Experimental Septoplasty Simulation","authors":"M. Kostyaeva, I. Kastyro, T. Yunusov, T. Kolomin, V. Torshin, V. I. Popadyuk, S. Dragunova, S. Shilin, V. K. Kleiman, P. Slominsky, A. Y. Teplov","doi":"10.3103/S0891416822010037","DOIUrl":"https://doi.org/10.3103/S0891416822010037","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"5 1","pages":"19 - 24"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79663384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.3103/S0891416822010049
T. Kudryavtseva, A. N. Mokrievich
{"title":"Molecular-Genetic Bases of Differences between Tularaemia Pathogen Subspecies and Francisella tularensis subsp. holarctica Strain Typing","authors":"T. Kudryavtseva, A. N. Mokrievich","doi":"10.3103/S0891416822010049","DOIUrl":"https://doi.org/10.3103/S0891416822010049","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"1 1","pages":"10 - 18"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72958295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.3103/S0891416822010074
Zahra Vaghar, S. Khodavaisy, H. Badali, A. Sabokbar
{"title":"Molecular Detection of Azole-Resistant Aspergillus fumigatus Isolates Carrying TR34/L98H Mutations in Soil Samples from the Critical Hospitals","authors":"Zahra Vaghar, S. Khodavaisy, H. Badali, A. Sabokbar","doi":"10.3103/S0891416822010074","DOIUrl":"https://doi.org/10.3103/S0891416822010074","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"318 1","pages":"49 - 53"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80164687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.3103/S0891416822010086
I. B. Zakharova, K. V. Vasilyeva, L. Bui, A. Victorov, I. Shpak, D. Viktorov
{"title":"Genetic and Morphological Diversity of the Vietnamese Population of Burkholderia thailandensis","authors":"I. B. Zakharova, K. V. Vasilyeva, L. Bui, A. Victorov, I. Shpak, D. Viktorov","doi":"10.3103/S0891416822010086","DOIUrl":"https://doi.org/10.3103/S0891416822010086","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"21 1","pages":"34 - 46"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81304145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.17116/molgen20224001121
M. Kostyaeva, I. Kastyro, T. Yunusov, T. Kolomin, V. Torshin, V. I. Popadyuk, S. Dragunova, S. Shilin, V. K. Kleiman, P. Slominsky, A. Teplov
This study evaluated the dependence of p53 protein expression on the occurrence of dark neurons (DNs) in the hippocampus of rats during experimental modeling of septoplasty. Septoplasty simulation was carried out on 15 sexually mature male Wistar rats. We studied histological sections of the hippocampus stained with Nissl toluidine blue and antibodies to p53 protein. In the CA1 subfield, the number of p53-positive neurons significantly increased on the second, fourth ( p < 0.001), and sixth days ( p < 0.05). Dynamic assessment detected the peak of p53 protein expression in the cytoplasm of CA1 and CA2 neurons from the second to fourth days after surgery, while the number of these neurons decreased on the sixth day ( p < 0.001). In the cytoplasm of CA3 neurons at all periods after surgery, the expression of p53 protein increased compared to the control group. In the CA1 pyramidal layer, the number of DNs decreased on the sixth day ( p < 0.001). After 2 days, the minimal number of DNs was noted in CA2 compared with the fourth day ( p < 0.001). In CA3, there was a peak in number of DNs on the fourth day compared with the other days ( p < 0.001). A strong positive correlation was found at all periods of assessment and in all subfields of the hippocampus between the increase in the number of dark and p53-positive neurons. The occurrence of dark and p53-positive neurons in the hippocampal formation of rats after septoplasty modeling is a typical response of nervous tissue to stress. It is obvious that the expression of p53 protein is associated with basophilia of neural cytoplasm and the morphofunctional state of neurons. Presumably, the p53 protein can trigger not only the activation of damaged neurons in the hippocampus, but can also play a neuroprotective role. Upcoming studies should determine the role of p53 protein in further fate of damaged neurons in the pyramidal layer and differentiate the mechanisms of its expression.
{"title":"Protein p53 Expression and Dark Neurons in Rat Hippocampus after Experimental Septoplasty Simulation","authors":"M. Kostyaeva, I. Kastyro, T. Yunusov, T. Kolomin, V. Torshin, V. I. Popadyuk, S. Dragunova, S. Shilin, V. K. Kleiman, P. Slominsky, A. Teplov","doi":"10.17116/molgen20224001121","DOIUrl":"https://doi.org/10.17116/molgen20224001121","url":null,"abstract":"This study evaluated the dependence of p53 protein expression on the occurrence of dark neurons (DNs) in the hippocampus of rats during experimental modeling of septoplasty. Septoplasty simulation was carried out on 15 sexually mature male Wistar rats. We studied histological sections of the hippocampus stained with Nissl toluidine blue and antibodies to p53 protein. In the CA1 subfield, the number of p53-positive neurons significantly increased on the second, fourth ( p < 0.001), and sixth days ( p < 0.05). Dynamic assessment detected the peak of p53 protein expression in the cytoplasm of CA1 and CA2 neurons from the second to fourth days after surgery, while the number of these neurons decreased on the sixth day ( p < 0.001). In the cytoplasm of CA3 neurons at all periods after surgery, the expression of p53 protein increased compared to the control group. In the CA1 pyramidal layer, the number of DNs decreased on the sixth day ( p < 0.001). After 2 days, the minimal number of DNs was noted in CA2 compared with the fourth day ( p < 0.001). In CA3, there was a peak in number of DNs on the fourth day compared with the other days ( p < 0.001). A strong positive correlation was found at all periods of assessment and in all subfields of the hippocampus between the increase in the number of dark and p53-positive neurons. The occurrence of dark and p53-positive neurons in the hippocampal formation of rats after septoplasty modeling is a typical response of nervous tissue to stress. It is obvious that the expression of p53 protein is associated with basophilia of neural cytoplasm and the morphofunctional state of neurons. Presumably, the p53 protein can trigger not only the activation of damaged neurons in the hippocampus, but can also play a neuroprotective role. Upcoming studies should determine the role of p53 protein in further fate of damaged neurons in the pyramidal layer and differentiate the mechanisms of its expression.","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"3 1","pages":"19-24"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89523003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.3103/S0891416822010062
T. Voeikova, V. Kuligin, A. D. Novikov, O. Zhuravliova, A. Skorokhodova, V. G. Debabov
{"title":"Regulatory Assessment of Characteristics of Genetically Modified E. coli K-12 VKPM B-13285 Strain, Succinic Acid Producer. Analysis of Strain Behavior under the Influence of Environmental Factors","authors":"T. Voeikova, V. Kuligin, A. D. Novikov, O. Zhuravliova, A. Skorokhodova, V. G. Debabov","doi":"10.3103/S0891416822010062","DOIUrl":"https://doi.org/10.3103/S0891416822010062","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"30 1","pages":"25 - 33"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81997437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.3103/S0891416822010050
A. Sorokan, V. Alekseev
{"title":"Producing Cry-Toxins Endophytic Bacteria as an Alternative to Transgenic Plants to Protect Potato Plants against Colorado Potato Beetle","authors":"A. Sorokan, V. Alekseev","doi":"10.3103/S0891416822010050","DOIUrl":"https://doi.org/10.3103/S0891416822010050","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"373 1","pages":"47 - 48"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84942470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.17116/molgen20224001146
A. Sorokan, V. Alekseev
Abstract Leptinotarsa decemlineata ( Ld ) can develop resistance to chemical and biological insecticides. It is important to search for microbial symbionts of plants that increase their adaptive potential. It was shown that the endophytic cells of Bacillus thuringiensis B-5351 increases Ld larvae mortality and activates the transcription of genes of proteinase inhibitors and their protein products in potato plants after pest damage, in contrast to the “low endophytic” B. thuringiensis B-5659, which produces highly effective insectotoxins.
{"title":"Producing Cry-Toxins Endophytic Bacteria as an Alternative to Transgenic Plants to Protect Potato Plants against Colorado Potato Beetle","authors":"A. Sorokan, V. Alekseev","doi":"10.17116/molgen20224001146","DOIUrl":"https://doi.org/10.17116/molgen20224001146","url":null,"abstract":"Abstract Leptinotarsa decemlineata ( Ld ) can develop resistance to chemical and biological insecticides. It is important to search for microbial symbionts of plants that increase their adaptive potential. It was shown that the endophytic cells of Bacillus thuringiensis B-5351 increases Ld larvae mortality and activates the transcription of genes of proteinase inhibitors and their protein products in potato plants after pest damage, in contrast to the “low endophytic” B. thuringiensis B-5659, which produces highly effective insectotoxins.","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"231 1","pages":"47-48"},"PeriodicalIF":0.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76263855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.3103/S0891416821050086
Sonia Hassani, F. Sotoodehnejadnematalahi, A. Fateh, S. Siadat
{"title":"Evaluation of Association between Bifidobacterium bifidum Derived Extracellular Vesicles and Intestinal Epithelium Tight Junction Proteins through Notch-1 and AhR Activation in Caco-2 Cell Line","authors":"Sonia Hassani, F. Sotoodehnejadnematalahi, A. Fateh, S. Siadat","doi":"10.3103/S0891416821050086","DOIUrl":"https://doi.org/10.3103/S0891416821050086","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"28 1","pages":"S1 - S6"},"PeriodicalIF":0.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75831541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.3103/S0891416821050098
Hadia Ibrar, N. Masood, Saima Shakil Malik
{"title":"Role of XPG Gene Polymorphism towards Colorectal Cancer Susceptibility: A Case Control Study","authors":"Hadia Ibrar, N. Masood, Saima Shakil Malik","doi":"10.3103/S0891416821050098","DOIUrl":"https://doi.org/10.3103/S0891416821050098","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"140 1","pages":"S37 - S41"},"PeriodicalIF":0.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77772414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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