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Molecular Therapy最新文献

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Highly Efficient and Durable Th1-Biased Protective Immunity Induced by a Novel mRNA-LNP Vaccine Against RSV via AI-Assisted Antigen Screening 基于ai辅助抗原筛选的新型rna - lnp抗RSV疫苗诱导高效持久的th1偏倚保护性免疫
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-29 DOI: 10.1016/j.ymthe.2026.01.031
Kai Dong, Fang Liu, Man Zhang, Yuting Zhou, Fei Yu, Wang Wang, Xin Chai, Jing Li, Gengshen Song
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引用次数: 0
Tumor Cell AMPK Activation Enhances NK Cell Anti-tumor Immunity and Synergizes with PD-L1 Blockade Therapy 肿瘤细胞AMPK激活增强NK细胞抗肿瘤免疫并与PD-L1阻断治疗协同作用
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-29 DOI: 10.1016/j.ymthe.2026.01.032
Zhen Lu, Jiacheng Bi, Chaoyue Zheng, Lulu Cui, Houjun Xia, Xiaochun Wan, Youhai H. Chen
{"title":"Tumor Cell AMPK Activation Enhances NK Cell Anti-tumor Immunity and Synergizes with PD-L1 Blockade Therapy","authors":"Zhen Lu, Jiacheng Bi, Chaoyue Zheng, Lulu Cui, Houjun Xia, Xiaochun Wan, Youhai H. Chen","doi":"10.1016/j.ymthe.2026.01.032","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.032","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"44 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Therapy Family Highlights 分子疗法家族亮点
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-28 DOI: 10.1016/j.ymthe.2026.01.013
{"title":"Molecular Therapy Family Highlights","authors":"","doi":"10.1016/j.ymthe.2026.01.013","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.013","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"17 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Could gene therapy delivered to the liver cure type 1 diabetes? 基因治疗能治愈1型糖尿病吗？
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-24 DOI: 10.1016/j.ymthe.2026.01.014
Christopher J Nolan
{"title":"Could gene therapy delivered to the liver cure type 1 diabetes?","authors":"Christopher J Nolan","doi":"10.1016/j.ymthe.2026.01.014","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.014","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"88 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time for resistance: New tools and strategies for microglia replacement. 抵抗的时间：小胶质细胞替代的新工具和策略。
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-24 DOI: 10.1016/j.ymthe.2026.01.011
Laura Meysman,Kiavash Movahedi
{"title":"Time for resistance: New tools and strategies for microglia replacement.","authors":"Laura Meysman,Kiavash Movahedi","doi":"10.1016/j.ymthe.2026.01.011","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.011","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"44 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AFP specific T cell receptors with fine-tune affinity induce durable tumor remission in mice and acquire pan-HLA-A*02 recognition 具有微调亲和力的AFP特异性T细胞受体诱导小鼠持久肿瘤缓解并获得泛hla - a *02识别
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-23 DOI: 10.1016/j.ymthe.2026.01.026
Chen-Song Huang, Jiajia Du, Jun Li, Ya-Hao Guo, Qingjia Yan, Shifan Wu, Xihe Chen, Tein Foong Leong, Si-Yun Chen, An-Da Zheng, Shudan Ou, Minjun Ma, Chunguang Yang, Lulu Zhang, Xiangjun Zhou, Junjun Chu, Yanyan Han
{"title":"AFP specific T cell receptors with fine-tune affinity induce durable tumor remission in mice and acquire pan-HLA-A*02 recognition","authors":"Chen-Song Huang, Jiajia Du, Jun Li, Ya-Hao Guo, Qingjia Yan, Shifan Wu, Xihe Chen, Tein Foong Leong, Si-Yun Chen, An-Da Zheng, Shudan Ou, Minjun Ma, Chunguang Yang, Lulu Zhang, Xiangjun Zhou, Junjun Chu, Yanyan Han","doi":"10.1016/j.ymthe.2026.01.026","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.026","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"268 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid lineage CAR knock-in mice enable allogeneic immunotherapy for liver and lung fibrosis 髓系CAR敲入小鼠实现肝和肺纤维化的异体免疫治疗
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-23 DOI: 10.1016/j.ymthe.2026.01.027
Min Wang, Yaoyang Zhang, Qinyao Zhu, Lili Guan, Yue Xun, Yifan Liu, Yu Liu, Yuxin Hao, Shuai Liu, Huan Li, Xiaojiao Shan, Xuelong Li, Xiaobin Fang, Yue Ju, Xiyang Liu, Shuyue Xia, Xiushan Yin, Luo Zhang
{"title":"Myeloid lineage CAR knock-in mice enable allogeneic immunotherapy for liver and lung fibrosis","authors":"Min Wang, Yaoyang Zhang, Qinyao Zhu, Lili Guan, Yue Xun, Yifan Liu, Yu Liu, Yuxin Hao, Shuai Liu, Huan Li, Xiaojiao Shan, Xuelong Li, Xiaobin Fang, Yue Ju, Xiyang Liu, Shuyue Xia, Xiushan Yin, Luo Zhang","doi":"10.1016/j.ymthe.2026.01.027","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.027","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"49 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of the HCK-GS-HIF1α axis, a promising druggable target for aggressive TNBC 调控HCK-GS-HIF1α轴，这是侵袭性TNBC的一个有希望的药物靶点
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-23 DOI: 10.1016/j.ymthe.2026.01.012
Angel Pulido Capiz, Victor García-González
{"title":"Regulation of the HCK-GS-HIF1α axis, a promising druggable target for aggressive TNBC","authors":"Angel Pulido Capiz, Victor García-González","doi":"10.1016/j.ymthe.2026.01.012","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.012","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"85 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALCAT1 Promotes Diabetic Cardiomyopathy by Linking Myocardial Tetralinoleoyl Cardiolipin Deficiency to Lipotoxicity ALCAT1促进糖尿病性心肌病，将心肌四钠油基心磷脂缺乏与脂肪毒性联系起来
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-23 DOI: 10.1016/j.ymthe.2026.01.025
Dandan Jia, Yuguang Shi
{"title":"ALCAT1 Promotes Diabetic Cardiomyopathy by Linking Myocardial Tetralinoleoyl Cardiolipin Deficiency to Lipotoxicity","authors":"Dandan Jia, Yuguang Shi","doi":"10.1016/j.ymthe.2026.01.025","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.025","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"69 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers 携带完全人类嵌合抗原受体的自体T细胞靶向间皮素治疗表达间皮素的癌症的I期研究
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-21 DOI: 10.1016/j.ymthe.2026.01.021
Julie S. Barber-Rotenberg, Andrew R. Haas, Charu Aggarwal, Mark O'Hara, Elizabeth Hexner, Edward Pequignot, Emily Dowd, Sonia Ndeupen, Elina Thai, Fang Chen, Bike Su Oner, Cory Czuczman, Vanessa E. Gonzalez, Joseph A. Fraietta, Wei-Ting Hwang, Anne Chew, Julie K. Jadlowsky, Amy Marshall, Kim-Marie Shea, Yan Jiang, Angela Cosey, Regina Ferthio, Bruce L. Levine, Gabriela Plesa, Don L. Siegel, Regina M. Young, Neil C. Sheppard, Steven M. Albelda, Carl H. June, Janos L. Tanyi
{"title":"Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers","authors":"Julie S. Barber-Rotenberg, Andrew R. Haas, Charu Aggarwal, Mark O'Hara, Elizabeth Hexner, Edward Pequignot, Emily Dowd, Sonia Ndeupen, Elina Thai, Fang Chen, Bike Su Oner, Cory Czuczman, Vanessa E. Gonzalez, Joseph A. Fraietta, Wei-Ting Hwang, Anne Chew, Julie K. Jadlowsky, Amy Marshall, Kim-Marie Shea, Yan Jiang, Angela Cosey, Regina Ferthio, Bruce L. Levine, Gabriela Plesa, Don L. Siegel, Regina M. Young, Neil C. Sheppard, Steven M. Albelda, Carl H. June, Janos L. Tanyi","doi":"10.1016/j.ymthe.2026.01.021","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.021","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"6 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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