Pub Date : 2026-01-23DOI: 10.1016/j.ymthe.2026.01.012
Angel Pulido Capiz, Victor García-González
{"title":"Regulation of the HCK-GS-HIF1α axis, a promising druggable target for aggressive TNBC","authors":"Angel Pulido Capiz, Victor García-González","doi":"10.1016/j.ymthe.2026.01.012","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.012","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"85 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.ymthe.2026.01.021
Julie S. Barber-Rotenberg, Andrew R. Haas, Charu Aggarwal, Mark O'Hara, Elizabeth Hexner, Edward Pequignot, Emily Dowd, Sonia Ndeupen, Elina Thai, Fang Chen, Bike Su Oner, Cory Czuczman, Vanessa E. Gonzalez, Joseph A. Fraietta, Wei-Ting Hwang, Anne Chew, Julie K. Jadlowsky, Amy Marshall, Kim-Marie Shea, Yan Jiang, Angela Cosey, Regina Ferthio, Bruce L. Levine, Gabriela Plesa, Don L. Siegel, Regina M. Young, Neil C. Sheppard, Steven M. Albelda, Carl H. June, Janos L. Tanyi
{"title":"Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers","authors":"Julie S. Barber-Rotenberg, Andrew R. Haas, Charu Aggarwal, Mark O'Hara, Elizabeth Hexner, Edward Pequignot, Emily Dowd, Sonia Ndeupen, Elina Thai, Fang Chen, Bike Su Oner, Cory Czuczman, Vanessa E. Gonzalez, Joseph A. Fraietta, Wei-Ting Hwang, Anne Chew, Julie K. Jadlowsky, Amy Marshall, Kim-Marie Shea, Yan Jiang, Angela Cosey, Regina Ferthio, Bruce L. Levine, Gabriela Plesa, Don L. Siegel, Regina M. Young, Neil C. Sheppard, Steven M. Albelda, Carl H. June, Janos L. Tanyi","doi":"10.1016/j.ymthe.2026.01.021","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.021","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"6 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.ymthe.2026.01.019
James Hugo Armstrong Clubb, Santeri Artturi Pakola, Sakari Joenväärä, Tatiana Viktorovna Kudling, Tiialotta Tohmola, Victor Arias, Elise Jirovec, Mirte van der Heijden, Dafne Carolina Alves Quixabeira, Annukka Pasanen, Lyna Haybout, Nea Ojala, Saru Basnet, Arianna Eleuteri, Julia Davila Ferrero, Stella Hirvenoja, Inge Marie Svane, Johanna Mäenpää, Katriina Jalkanen, Matthew Stephen Block, Tuomo Alanko, Tine Monberg, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Natasha Salmelin, Claudia Kistler, Riikka Havunen, Suvi Sorsa, João Manuel dos Santos, Victor Cervera-Carrascon, Anna Kanerva, Otto Hemminki, Risto Renkonen, Akseli Hemminki
{"title":"Dyslipidaemia-associated natural IgM improves oncolytic virus TILT-123 efficacy through antibody-dependent enhancement in solid tumours.","authors":"James Hugo Armstrong Clubb, Santeri Artturi Pakola, Sakari Joenväärä, Tatiana Viktorovna Kudling, Tiialotta Tohmola, Victor Arias, Elise Jirovec, Mirte van der Heijden, Dafne Carolina Alves Quixabeira, Annukka Pasanen, Lyna Haybout, Nea Ojala, Saru Basnet, Arianna Eleuteri, Julia Davila Ferrero, Stella Hirvenoja, Inge Marie Svane, Johanna Mäenpää, Katriina Jalkanen, Matthew Stephen Block, Tuomo Alanko, Tine Monberg, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Natasha Salmelin, Claudia Kistler, Riikka Havunen, Suvi Sorsa, João Manuel dos Santos, Victor Cervera-Carrascon, Anna Kanerva, Otto Hemminki, Risto Renkonen, Akseli Hemminki","doi":"10.1016/j.ymthe.2026.01.019","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.019","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"258 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.ymthe.2026.01.020
Yohei Kawai, Shin Kaneko
{"title":"Feeder-free generation of CD4 single-positive helper T cells from human iPSCs via stage-specific modulation of Notch and TCR Signaling","authors":"Yohei Kawai, Shin Kaneko","doi":"10.1016/j.ymthe.2026.01.020","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.020","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"63 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.ymthe.2026.01.017
Donovan Flumens, Diana Campillo-Davo, Florian Van Oers, Philip Anthony Gilbert Shaw, Eva Lion
{"title":"Strategies to eliminate native T cell receptors for adoptive T cell therapies","authors":"Donovan Flumens, Diana Campillo-Davo, Florian Van Oers, Philip Anthony Gilbert Shaw, Eva Lion","doi":"10.1016/j.ymthe.2026.01.017","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.017","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"213 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.ymthe.2026.01.024
Dawei Zou, Stephanie G. Yi, Yulin Dai, Luan Truong, Lillian W. Gaber, Richard L. Knight, Xiang Xiao, Rafik M. Ghobrial, Xian C. Li, Zhongming Zhao, Wenhao Chen, A.Osama Gaber
{"title":"CD8+ T cell differentiation into NK-like effector cells drives transplant rejection","authors":"Dawei Zou, Stephanie G. Yi, Yulin Dai, Luan Truong, Lillian W. Gaber, Richard L. Knight, Xiang Xiao, Rafik M. Ghobrial, Xian C. Li, Zhongming Zhao, Wenhao Chen, A.Osama Gaber","doi":"10.1016/j.ymthe.2026.01.024","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.024","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"85 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The disruption of vascular homeostasis is a key pathological feature of fundus abnormal vascular diseases, including wet age-related macular degeneration, diabetic macular edema, and retinal vein occlusion. While anti-vascular endothelial growth factor therapies are widely used, many patients exhibit limited or suboptimal responses. Through proteomic analysis of 173 aqueous humor samples from fundus abnormal vascular diseases patients, followed by validation in an independent cohort of 70 samples, this study identifies prosaposin as a potential therapeutic candidate. In vitro, prosaposin mitigated endothelial dysfunction and reduced vascular permeability, while in vivo, it demonstrated anti-angiogenic and anti-inflammatory effects comparable to aflibercept, effectively reducing vascular leakage and retinal edema. Additionally, prosaposin provided neuroprotection by preserving photoreceptor cells. These findings highlight prosaposin's dual role in maintaining vascular homeostasis and protecting neural tissues, suggesting its potential as an alternative treatment for patients unresponsive to anti- vascular endothelial growth factor therapies.
{"title":"Prosaposin is a Dual-Action Therapeutic Target for Vascular Stabilization and Neuroprotection.","authors":"Jianhao Bai,Sijie Li,Aiting Wang,Boqian Wang,Zhongqi Wan,Jiao Jiao Li,Yinghong Zhou,RenBing Jia,Haiying Jin,Peng Gao,Xianting Ding","doi":"10.1016/j.ymthe.2026.01.015","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.015","url":null,"abstract":"The disruption of vascular homeostasis is a key pathological feature of fundus abnormal vascular diseases, including wet age-related macular degeneration, diabetic macular edema, and retinal vein occlusion. While anti-vascular endothelial growth factor therapies are widely used, many patients exhibit limited or suboptimal responses. Through proteomic analysis of 173 aqueous humor samples from fundus abnormal vascular diseases patients, followed by validation in an independent cohort of 70 samples, this study identifies prosaposin as a potential therapeutic candidate. In vitro, prosaposin mitigated endothelial dysfunction and reduced vascular permeability, while in vivo, it demonstrated anti-angiogenic and anti-inflammatory effects comparable to aflibercept, effectively reducing vascular leakage and retinal edema. Additionally, prosaposin provided neuroprotection by preserving photoreceptor cells. These findings highlight prosaposin's dual role in maintaining vascular homeostasis and protecting neural tissues, suggesting its potential as an alternative treatment for patients unresponsive to anti- vascular endothelial growth factor therapies.","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"52 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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