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Molecular Therapy最新文献

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Time for resistance: New tools and strategies for microglia replacement. 抵抗的时间：小胶质细胞替代的新工具和策略。
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-24 DOI: 10.1016/j.ymthe.2026.01.011
Laura Meysman,Kiavash Movahedi
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引用次数: 0
AFP specific T cell receptors with fine-tune affinity induce durable tumor remission in mice and acquire pan-HLA-A*02 recognition 具有微调亲和力的AFP特异性T细胞受体诱导小鼠持久肿瘤缓解并获得泛hla - a *02识别
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-23 DOI: 10.1016/j.ymthe.2026.01.026
Chen-Song Huang, Jiajia Du, Jun Li, Ya-Hao Guo, Qingjia Yan, Shifan Wu, Xihe Chen, Tein Foong Leong, Si-Yun Chen, An-Da Zheng, Shudan Ou, Minjun Ma, Chunguang Yang, Lulu Zhang, Xiangjun Zhou, Junjun Chu, Yanyan Han
{"title":"AFP specific T cell receptors with fine-tune affinity induce durable tumor remission in mice and acquire pan-HLA-A*02 recognition","authors":"Chen-Song Huang, Jiajia Du, Jun Li, Ya-Hao Guo, Qingjia Yan, Shifan Wu, Xihe Chen, Tein Foong Leong, Si-Yun Chen, An-Da Zheng, Shudan Ou, Minjun Ma, Chunguang Yang, Lulu Zhang, Xiangjun Zhou, Junjun Chu, Yanyan Han","doi":"10.1016/j.ymthe.2026.01.026","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.026","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"268 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid lineage CAR knock-in mice enable allogeneic immunotherapy for liver and lung fibrosis 髓系CAR敲入小鼠实现肝和肺纤维化的异体免疫治疗
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-23 DOI: 10.1016/j.ymthe.2026.01.027
Min Wang, Yaoyang Zhang, Qinyao Zhu, Lili Guan, Yue Xun, Yifan Liu, Yu Liu, Yuxin Hao, Shuai Liu, Huan Li, Xiaojiao Shan, Xuelong Li, Xiaobin Fang, Yue Ju, Xiyang Liu, Shuyue Xia, Xiushan Yin, Luo Zhang
{"title":"Myeloid lineage CAR knock-in mice enable allogeneic immunotherapy for liver and lung fibrosis","authors":"Min Wang, Yaoyang Zhang, Qinyao Zhu, Lili Guan, Yue Xun, Yifan Liu, Yu Liu, Yuxin Hao, Shuai Liu, Huan Li, Xiaojiao Shan, Xuelong Li, Xiaobin Fang, Yue Ju, Xiyang Liu, Shuyue Xia, Xiushan Yin, Luo Zhang","doi":"10.1016/j.ymthe.2026.01.027","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.027","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"49 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of the HCK-GS-HIF1α axis, a promising druggable target for aggressive TNBC 调控HCK-GS-HIF1α轴，这是侵袭性TNBC的一个有希望的药物靶点
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-23 DOI: 10.1016/j.ymthe.2026.01.012
Angel Pulido Capiz, Victor García-González
{"title":"Regulation of the HCK-GS-HIF1α axis, a promising druggable target for aggressive TNBC","authors":"Angel Pulido Capiz, Victor García-González","doi":"10.1016/j.ymthe.2026.01.012","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.012","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"85 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALCAT1 Promotes Diabetic Cardiomyopathy by Linking Myocardial Tetralinoleoyl Cardiolipin Deficiency to Lipotoxicity ALCAT1促进糖尿病性心肌病，将心肌四钠油基心磷脂缺乏与脂肪毒性联系起来
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-23 DOI: 10.1016/j.ymthe.2026.01.025
Dandan Jia, Yuguang Shi
{"title":"ALCAT1 Promotes Diabetic Cardiomyopathy by Linking Myocardial Tetralinoleoyl Cardiolipin Deficiency to Lipotoxicity","authors":"Dandan Jia, Yuguang Shi","doi":"10.1016/j.ymthe.2026.01.025","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.025","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"69 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers 携带完全人类嵌合抗原受体的自体T细胞靶向间皮素治疗表达间皮素的癌症的I期研究
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-21 DOI: 10.1016/j.ymthe.2026.01.021
Julie S. Barber-Rotenberg, Andrew R. Haas, Charu Aggarwal, Mark O'Hara, Elizabeth Hexner, Edward Pequignot, Emily Dowd, Sonia Ndeupen, Elina Thai, Fang Chen, Bike Su Oner, Cory Czuczman, Vanessa E. Gonzalez, Joseph A. Fraietta, Wei-Ting Hwang, Anne Chew, Julie K. Jadlowsky, Amy Marshall, Kim-Marie Shea, Yan Jiang, Angela Cosey, Regina Ferthio, Bruce L. Levine, Gabriela Plesa, Don L. Siegel, Regina M. Young, Neil C. Sheppard, Steven M. Albelda, Carl H. June, Janos L. Tanyi
{"title":"Phase I study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers","authors":"Julie S. Barber-Rotenberg, Andrew R. Haas, Charu Aggarwal, Mark O'Hara, Elizabeth Hexner, Edward Pequignot, Emily Dowd, Sonia Ndeupen, Elina Thai, Fang Chen, Bike Su Oner, Cory Czuczman, Vanessa E. Gonzalez, Joseph A. Fraietta, Wei-Ting Hwang, Anne Chew, Julie K. Jadlowsky, Amy Marshall, Kim-Marie Shea, Yan Jiang, Angela Cosey, Regina Ferthio, Bruce L. Levine, Gabriela Plesa, Don L. Siegel, Regina M. Young, Neil C. Sheppard, Steven M. Albelda, Carl H. June, Janos L. Tanyi","doi":"10.1016/j.ymthe.2026.01.021","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.021","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"6 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JMJD3 and UTX as Key Targets for Gene-Modified Mesenchymal Stem Cell Therapy in Cartilage Tissue Engineering JMJD3和UTX作为软骨组织工程中基因修饰间充质干细胞治疗的关键靶点
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-21 DOI: 10.1016/j.ymthe.2026.01.018
Lyess Allas, Juliette Aury-Landas, Quitterie Rochoux-Briet, Anais Julien, Eva Lhuissier, Marion Lente, Sybille Brochard, Alexis Veyssiere, Karim Boumédiene, Catherine Baugé
{"title":"JMJD3 and UTX as Key Targets for Gene-Modified Mesenchymal Stem Cell Therapy in Cartilage Tissue Engineering","authors":"Lyess Allas, Juliette Aury-Landas, Quitterie Rochoux-Briet, Anais Julien, Eva Lhuissier, Marion Lente, Sybille Brochard, Alexis Veyssiere, Karim Boumédiene, Catherine Baugé","doi":"10.1016/j.ymthe.2026.01.018","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.018","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"116 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dyslipidaemia-associated natural IgM improves oncolytic virus TILT-123 efficacy through antibody-dependent enhancement in solid tumours. 血脂异常相关的天然IgM通过抗体依赖性增强在实体肿瘤中提高溶瘤病毒TILT-123的疗效。
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-21 DOI: 10.1016/j.ymthe.2026.01.019
James Hugo Armstrong Clubb, Santeri Artturi Pakola, Sakari Joenväärä, Tatiana Viktorovna Kudling, Tiialotta Tohmola, Victor Arias, Elise Jirovec, Mirte van der Heijden, Dafne Carolina Alves Quixabeira, Annukka Pasanen, Lyna Haybout, Nea Ojala, Saru Basnet, Arianna Eleuteri, Julia Davila Ferrero, Stella Hirvenoja, Inge Marie Svane, Johanna Mäenpää, Katriina Jalkanen, Matthew Stephen Block, Tuomo Alanko, Tine Monberg, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Natasha Salmelin, Claudia Kistler, Riikka Havunen, Suvi Sorsa, João Manuel dos Santos, Victor Cervera-Carrascon, Anna Kanerva, Otto Hemminki, Risto Renkonen, Akseli Hemminki
{"title":"Dyslipidaemia-associated natural IgM improves oncolytic virus TILT-123 efficacy through antibody-dependent enhancement in solid tumours.","authors":"James Hugo Armstrong Clubb, Santeri Artturi Pakola, Sakari Joenväärä, Tatiana Viktorovna Kudling, Tiialotta Tohmola, Victor Arias, Elise Jirovec, Mirte van der Heijden, Dafne Carolina Alves Quixabeira, Annukka Pasanen, Lyna Haybout, Nea Ojala, Saru Basnet, Arianna Eleuteri, Julia Davila Ferrero, Stella Hirvenoja, Inge Marie Svane, Johanna Mäenpää, Katriina Jalkanen, Matthew Stephen Block, Tuomo Alanko, Tine Monberg, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Natasha Salmelin, Claudia Kistler, Riikka Havunen, Suvi Sorsa, João Manuel dos Santos, Victor Cervera-Carrascon, Anna Kanerva, Otto Hemminki, Risto Renkonen, Akseli Hemminki","doi":"10.1016/j.ymthe.2026.01.019","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.019","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"258 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feeder-free generation of CD4 single-positive helper T cells from human iPSCs via stage-specific modulation of Notch and TCR Signaling 通过Notch和TCR信号的阶段特异性调节，人iPSCs无馈源产生CD4单阳性辅助性T细胞
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-21 DOI: 10.1016/j.ymthe.2026.01.020
Yohei Kawai, Shin Kaneko
{"title":"Feeder-free generation of CD4 single-positive helper T cells from human iPSCs via stage-specific modulation of Notch and TCR Signaling","authors":"Yohei Kawai, Shin Kaneko","doi":"10.1016/j.ymthe.2026.01.020","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.020","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"63 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to eliminate native T cell receptors for adoptive T cell therapies 在过继性T细胞治疗中消除天然T细胞受体的策略
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-21 DOI: 10.1016/j.ymthe.2026.01.017
Donovan Flumens, Diana Campillo-Davo, Florian Van Oers, Philip Anthony Gilbert Shaw, Eva Lion
{"title":"Strategies to eliminate native T cell receptors for adoptive T cell therapies","authors":"Donovan Flumens, Diana Campillo-Davo, Florian Van Oers, Philip Anthony Gilbert Shaw, Eva Lion","doi":"10.1016/j.ymthe.2026.01.017","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.017","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"213 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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