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Molecular Therapy最新文献

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Modification of the VP1u region boosts transduction of adeno-associated virus vectors for ocular gene therapy VP1u区的修饰促进了用于眼部基因治疗的腺相关病毒载体的转导
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-30 DOI: 10.1016/j.ymthe.2026.01.029
Mengtian Cui, Shun-Yun Cheng, Jialing Liang, Jackson McGowan, Meiyu Xu, Guangchao Xu, Li Luo, Joae Wu, Christine D. Harman, Amanda L. Jacobson, Lydia E. Kapeller, Melaney A. Mayes, Suk Namkung, Tapan Sharma, Thomas B. Leland, Fang Zhang, Mitchell Yip, Brian Rossmiller, Thomas Xue, Xiupeng Chen, Wassamon Boonying, Anoushka Lotun, Dan Wang, Qin Su, Jun Xie, Yuquan Wei, Ann M. Rothstein, Meredith S. Gregory-Ksander, Andras Komaromy, Bo Tian, Haijiang Lin, Claudio Punzo, Phillip W.L. Tai, Guangping Gao
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引用次数: 0
DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression DANCR通过增强IL-11-STAT3信号和CCND1表达促进膀胱癌细胞的转移和增殖
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-30 DOI: 10.1016/j.ymthe.2026.01.035
Ziyue Chen, Xu Chen, Ruihui Xie, Ming Huang, Wen Dong, Jinli Han, Jingtong Zhang, Qianghua Zhou, Hui Li, Jian Huang, Tianxin Lin
{"title":"DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression","authors":"Ziyue Chen, Xu Chen, Ruihui Xie, Ming Huang, Wen Dong, Jinli Han, Jingtong Zhang, Qianghua Zhou, Hui Li, Jian Huang, Tianxin Lin","doi":"10.1016/j.ymthe.2026.01.035","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.035","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"30 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Adoptive T Cell Therapy by Disrupting the SKI-SMAD2/3 Axis to Counteract TGF-β-Mediated Immunosuppression 通过破坏SKI-SMAD2/3轴对抗TGF-β介导的免疫抑制来增强过继T细胞治疗
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-29 DOI: 10.1016/j.ymthe.2026.01.028
Xiaohan Jin, Jingxuan Yu, Xinyu Wu, Qingyong Hu, Xixi Chen, Wenbo Ma, Yude Guan, Dongmei Guo, Yulan Yang, Lingyu Wang, Guofei Jin, Zhenglan Han, Shumin Zhang, Nianchao Zhang
{"title":"Enhancing Adoptive T Cell Therapy by Disrupting the SKI-SMAD2/3 Axis to Counteract TGF-β-Mediated Immunosuppression","authors":"Xiaohan Jin, Jingxuan Yu, Xinyu Wu, Qingyong Hu, Xixi Chen, Wenbo Ma, Yude Guan, Dongmei Guo, Yulan Yang, Lingyu Wang, Guofei Jin, Zhenglan Han, Shumin Zhang, Nianchao Zhang","doi":"10.1016/j.ymthe.2026.01.028","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.028","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"279 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of hydrocephalus with a small oligonucleotide 小寡核苷酸预防脑积水
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-29 DOI: 10.1016/j.ymthe.2026.01.034
Lilit Antonyan, Linda Bossini, Xin Zhang, Anjie Ni, Marc-Daniel Hagel, Eva Baronchelli, Martina Geusa, Huashan Peng, Amelia Semenak, Peter Fleming, Shaima Alsuwaidi, Ying Zhang, Beili Hu, Diletta Fontana, Valentina Crippa, Stefania Codazzi, Julia Macintosh, Andres Arriaga-Sierra, Basil Khan, Nuwan Hettige, Malvin Jefri, Yijing Liang, Stephanie Klein, André du Toit, Nhu T.N. Phan, Andreas Schuppert, Yang Zhou, Rocco Piazza, Keith Murai, Sebastien Jacquemont, Alessandro Sessa, Carl Ernst
{"title":"Prevention of hydrocephalus with a small oligonucleotide","authors":"Lilit Antonyan, Linda Bossini, Xin Zhang, Anjie Ni, Marc-Daniel Hagel, Eva Baronchelli, Martina Geusa, Huashan Peng, Amelia Semenak, Peter Fleming, Shaima Alsuwaidi, Ying Zhang, Beili Hu, Diletta Fontana, Valentina Crippa, Stefania Codazzi, Julia Macintosh, Andres Arriaga-Sierra, Basil Khan, Nuwan Hettige, Malvin Jefri, Yijing Liang, Stephanie Klein, André du Toit, Nhu T.N. Phan, Andreas Schuppert, Yang Zhou, Rocco Piazza, Keith Murai, Sebastien Jacquemont, Alessandro Sessa, Carl Ernst","doi":"10.1016/j.ymthe.2026.01.034","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.034","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"28 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulation of Serpinb6a-Gch1 axis contributes to DFNB91 deafness that is amendable to gene therapies Serpinb6a-Gch1轴的失调导致DFNB91耳聋，这可以通过基因治疗来修复
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-29 DOI: 10.1016/j.ymthe.2026.01.030
Cheng Cheng, Liyan Zhang, Jie Lu, Fangzhi Tan, Yideng Huang, Song Gao, Siyu Li, Yue Qiu, Wenli Hao, Yingyi Zhou, Junze Lu, Xinya Ji, Ao Li, Xinru Zhang, Jinyi Fan, He Li, Xiaoyun Qian, Jieyu Qi, Xia Gao, Renjie Chai
{"title":"Dysregulation of Serpinb6a-Gch1 axis contributes to DFNB91 deafness that is amendable to gene therapies","authors":"Cheng Cheng, Liyan Zhang, Jie Lu, Fangzhi Tan, Yideng Huang, Song Gao, Siyu Li, Yue Qiu, Wenli Hao, Yingyi Zhou, Junze Lu, Xinya Ji, Ao Li, Xinru Zhang, Jinyi Fan, He Li, Xiaoyun Qian, Jieyu Qi, Xia Gao, Renjie Chai","doi":"10.1016/j.ymthe.2026.01.030","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.030","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"188 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth 靶向IRS2的白蛋白结合siRNA治疗性递送可降低乳腺肿瘤的生长
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-29 DOI: 10.1016/j.ymthe.2026.01.033
Claire E. Tocheny, Julianna E. Buchwald, Christopher D. Dahlke, Hassan H. Fakih, Jennifer S. Morgan, Ashley Summers, Christi A. Silva, Samuel O. Jackson, Ji-Sun Lee, Michael-Anthony Card, Dimas Echeverria, Cornelia Peterson, Arthur M. Mercurio, Anastasia Khvorova, Leslie M. Shaw
{"title":"Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth","authors":"Claire E. Tocheny, Julianna E. Buchwald, Christopher D. Dahlke, Hassan H. Fakih, Jennifer S. Morgan, Ashley Summers, Christi A. Silva, Samuel O. Jackson, Ji-Sun Lee, Michael-Anthony Card, Dimas Echeverria, Cornelia Peterson, Arthur M. Mercurio, Anastasia Khvorova, Leslie M. Shaw","doi":"10.1016/j.ymthe.2026.01.033","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.033","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"260 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly Efficient and Durable Th1-Biased Protective Immunity Induced by a Novel mRNA-LNP Vaccine Against RSV via AI-Assisted Antigen Screening 基于ai辅助抗原筛选的新型rna - lnp抗RSV疫苗诱导高效持久的th1偏倚保护性免疫
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-29 DOI: 10.1016/j.ymthe.2026.01.031
Kai Dong, Fang Liu, Man Zhang, Yuting Zhou, Fei Yu, Wang Wang, Xin Chai, Jing Li, Gengshen Song
{"title":"Highly Efficient and Durable Th1-Biased Protective Immunity Induced by a Novel mRNA-LNP Vaccine Against RSV via AI-Assisted Antigen Screening","authors":"Kai Dong, Fang Liu, Man Zhang, Yuting Zhou, Fei Yu, Wang Wang, Xin Chai, Jing Li, Gengshen Song","doi":"10.1016/j.ymthe.2026.01.031","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.031","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"8 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor Cell AMPK Activation Enhances NK Cell Anti-tumor Immunity and Synergizes with PD-L1 Blockade Therapy 肿瘤细胞AMPK激活增强NK细胞抗肿瘤免疫并与PD-L1阻断治疗协同作用
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-29 DOI: 10.1016/j.ymthe.2026.01.032
Zhen Lu, Jiacheng Bi, Chaoyue Zheng, Lulu Cui, Houjun Xia, Xiaochun Wan, Youhai H. Chen
{"title":"Tumor Cell AMPK Activation Enhances NK Cell Anti-tumor Immunity and Synergizes with PD-L1 Blockade Therapy","authors":"Zhen Lu, Jiacheng Bi, Chaoyue Zheng, Lulu Cui, Houjun Xia, Xiaochun Wan, Youhai H. Chen","doi":"10.1016/j.ymthe.2026.01.032","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.032","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"44 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Therapy Family Highlights 分子疗法家族亮点
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-28 DOI: 10.1016/j.ymthe.2026.01.013
{"title":"Molecular Therapy Family Highlights","authors":"","doi":"10.1016/j.ymthe.2026.01.013","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.013","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"17 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Could gene therapy delivered to the liver cure type 1 diabetes? 基因治疗能治愈1型糖尿病吗？
IF 12.4 1区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Molecular Therapy
Pub Date : 2026-01-24 DOI: 10.1016/j.ymthe.2026.01.014
Christopher J Nolan
{"title":"Could gene therapy delivered to the liver cure type 1 diabetes?","authors":"Christopher J Nolan","doi":"10.1016/j.ymthe.2026.01.014","DOIUrl":"https://doi.org/10.1016/j.ymthe.2026.01.014","url":null,"abstract":"","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"88 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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