Given the growing importance of nonalcoholic fatty liver disease (NAFLD) and its inflammatory manifestation (nonalcoholic steatohepatitis [NASH]), the
鉴于非酒精性脂肪性肝病(NAFLD)及其炎症表现(非酒精性脂肪性肝炎[NASH])日益重要
{"title":"Two New Studies of Nonalcoholic Steatohepatitis","authors":"A. Brett","doi":"10.1056/NEJM-JW.NA54215","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54215","url":null,"abstract":"Given the growing importance of nonalcoholic fatty liver disease (NAFLD) and its inflammatory manifestation (nonalcoholic steatohepatitis [NASH]), the","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77074316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sympathetic neural activity presumably mediates white-coat hypertension. Researchers examined this relation in a study of 18 otherwise healthy patients
交感神经活动可能介导白大褂高血压。研究人员对18名其他方面健康的患者进行了研究，检验了这种关系
{"title":"A Closer Look at the “White-Coat” Blood Pressure Effect","authors":"A. Brett","doi":"10.1056/NEJM-JW.NA54200","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54200","url":null,"abstract":"Sympathetic neural activity presumably mediates white-coat hypertension. Researchers examined this relation in a study of 18 otherwise healthy patients","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83674643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Low-level HIV viremia (LLV; typically defined as HIV RNA above a specific lower limit of detection and below threshold for virologic failure) is
低水平HIV病毒血症;通常定义为HIV RNA高于特定的检测下限和低于病毒学失败的阈值)
{"title":"Low-Level HIV Viremia Related to Lower Cumulative Adherence to Antiretroviral Therapy","authors":"K. Henry","doi":"10.1056/NEJM-JW.NA54170","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54170","url":null,"abstract":"Low-level HIV viremia (LLV; typically defined as HIV RNA above a specific lower limit of detection and below threshold for virologic failure) is","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84680345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inhaled corticosteroids (ICS) are the mainstay of therapy for persistent asthma in children, but they have side effects, such as slowing of growth
吸入皮质类固醇(ICS)是儿童持续性哮喘的主要治疗方法，但它们有副作用，如生长减慢
{"title":"Do Inhaled Steroids Affect Childhood Obesity","authors":"D. Amrol","doi":"10.1056/NEJM-JW.NA54195","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54195","url":null,"abstract":"Inhaled corticosteroids (ICS) are the mainstay of therapy for persistent asthma in children, but they have side effects, such as slowing of growth","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77390370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the early stages of the COVID-19 pandemic, many centers had high thresholds for initiating extracorporeal membrane oxygenation (ECMO). During the
在COVID-19大流行的早期阶段，许多中心启动体外膜氧合(ECMO)的门槛很高。在
{"title":"Higher Mortality in COVID-19 Patients Who Received ECMO Later in the Pandemic","authors":"P. Kritek","doi":"10.1056/NEJM-JW.NA54158","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54158","url":null,"abstract":"In the early stages of the COVID-19 pandemic, many centers had high thresholds for initiating extracorporeal membrane oxygenation (ECMO). During the","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90705924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
New permanent pacemaker implantation (PPI) is required in up to 20% of patients after transcatheter aortic valve replacement (TAVR), but studies of
经导管主动脉瓣置换术(TAVR)后，高达20%的患者需要新的永久性起搏器植入(PPI)
{"title":"Do New Permanent Pacemakers Affect Outcomes After TAVR","authors":"H. Herrmann","doi":"10.1056/NEJM-JW.NA54172","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54172","url":null,"abstract":"New permanent pacemaker implantation (PPI) is required in up to 20% of patients after transcatheter aortic valve replacement (TAVR), but studies of","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89537263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preoperative chemoradiotherapy followed by surgery is standard treatment for locally advanced rectal cancer. Increasingly, total neoadjuvant therapy is
术前放化疗后手术是局部晚期直肠癌的标准治疗方法。总的新辅助治疗越来越多
{"title":"Delay to Surgery May Harm Rectal Cancer Nonresponders to Neoadjuvant Therapy","authors":"D. Ilson","doi":"10.1056/NEJM-JW.NA54197","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54197","url":null,"abstract":"Preoperative chemoradiotherapy followed by surgery is standard treatment for locally advanced rectal cancer. Increasingly, total neoadjuvant therapy is","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89058791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients with gait impairment caused by Parkinson disease (PD) often use compensation strategies that they have either learned about or devise
由帕金森病(PD)引起的步态障碍患者通常使用他们已经了解或设计的补偿策略
{"title":"Should We Employ Compensation Strategies for Parkinson Disease Gait Issues","authors":"M. Okun","doi":"10.1056/NEJM-JW.NA54184","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54184","url":null,"abstract":"Patients with gait impairment caused by Parkinson disease (PD) often use compensation strategies that they have either learned about or devise","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79621393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Observational studies suggest that rivaroxaban might confer higher risk for gastrointestinal (GI) bleeding than do other direct-acting oral
观察性研究表明，利伐沙班可能比其他直接作用的口服药物具有更高的胃肠道出血风险
{"title":"Do All DOACs Confer Similar GI Bleeding Risk","authors":"D. Dressler, Mhm, Facp.","doi":"10.1056/NEJM-JW.NA54178","DOIUrl":"https://doi.org/10.1056/NEJM-JW.NA54178","url":null,"abstract":"Observational studies suggest that rivaroxaban might confer higher risk for gastrointestinal (GI) bleeding than do other direct-acting oral","PeriodicalId":19048,"journal":{"name":"NEJM Journal Watch","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85742339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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