Nature Biomedical Engineering最新文献_第6页

Rotational ultrasound and photoacoustic tomography of the human body. 人体的旋转超声和光声断层扫描。

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-16 DOI: 10.1038/s41551-025-01603-5

Yang Zhang, Shuai Na, Jonathan J Russin, Karteekeya Sastry, Li Lin, Junfu Zheng, Yilin Luo, Xin Tong, Yujin An, Peng Hu, Konstantin Maslov, Tze-Woei Tan, Charles Y Liu, Lihong V Wang

Imaging the human body's morphological and angiographic information is essential for diagnosing, monitoring and treating medical conditions. Here we combine the power of ultrasonography for morphological assessment of soft tissue with photoacoustic tomography (PAT) for visualizing blood vessels to enable three-dimensional (3D) panoramic imaging. Specifically, fast panoramic rotational ultrasound tomography and PAT are integrated for hybrid rotational ultrasound and photoacoustic tomography (RUS-PAT), which obtains 3D ultrasound structural and PAT angiographic images of the human body quasi-simultaneously. The rotational ultrasound tomography functionality is achieved using a single-element ultrasonic transducer for ultrasound transmission and rotating arc-shaped arrays for 3D panoramic detection. By switching the acoustic source to a light source, the system is conveniently converted to PAT mode to acquire angiographic images in the same region. Using RUS-PAT, we successfully imaged the human head, breast, hand and foot with a 10-cm-diameter field of view, submillimetre isotropic resolution and 10 s imaging time for each modality. 3D RUS-PAT is a powerful tool for high-speed, dual-contrast imaging of the human body with potential for rapid clinical translation.

成像人体的形态和血管造影信息是必不可少的诊断，监测和治疗医疗条件。在这里，我们结合超声成像对软组织的形态学评估和光声断层扫描（PAT）血管的可视化，以实现三维（3D）全景成像。具体而言，将快速全景旋转超声断层扫描与PAT相结合，实现旋转超声与光声混合断层扫描（russ -PAT），可以准同时获得人体的三维超声结构和PAT血管造影图像。旋转超声断层扫描功能是使用用于超声波传输的单元件超声换能器和用于3D全景检测的旋转弧形阵列来实现的。通过将声源转换为光源，方便地将系统转换为PAT模式，以获取同一区域的血管造影图像。使用rs - pat，我们成功地对人的头部、乳房、手和脚进行了10厘米直径的视场成像，各向同性分辨率为亚毫米，每种模态成像时间为10 s。3D RUS-PAT是一种强大的工具，用于人体的高速、双对比度成像，具有快速临床转化的潜力。

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引用次数: 0

Chemically modified and inactivated bacteria enable intra-biofilm drug delivery and long-term immunity against implant infections. 化学修饰和灭活细菌使生物膜内药物传递和长期免疫种植体感染。

IF 28.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-16 DOI: 10.1038/s41551-025-01600-8

Chuang Yang,Qimanguli Saiding,Wei Chen,Soohwan An,Senfeng Zhao,Muhammad Muzamil Khan,Na Kong,Min Ge,Jianlin Shi,Han Lin,Wei Tao

Bacterial biofilms, prevalent in human infections, present a major barrier to effective antibacterial therapy due to limited drug permeability and resistance. Here we introduce a 'trick-bacteria-with-bacteria' strategy that employs bacteria modified via calcium chloride treatment and antibiotic loading, followed by ultraviolet inactivation. These modified bacteria integrate selectively into biofilms of the same species, enabling targeted intra-biofilm drug release triggered by local pH and hydrogen peroxide. Species-specific integration is essential, as mismatched strains exhibit spatial segregation due to differences in surface adhesins and protein profiles. The strategy is effective against polymicrobial biofilms and demonstrated efficacy in treating biofilms formed by Staphylococcus aureus, Escherichia coli and Candida albicans. It also reinvigorates biofilm-associated macrophages by inducing the release of biofilm-derived l-arginine, enhancing immune responses. In vivo studies using subcutaneous and bone implant infection models showed stronger biofilm eradication and longer-term immunity in animals treated with modified bacteria compared with those treated with antibiotics, including resistance to re-infection. This approach could be adapted to modify infection-related bacteria from patients for personalized intra-biofilm drug delivery.

细菌生物膜普遍存在于人类感染中，由于药物渗透性和耐药性有限，它是有效抗菌治疗的主要障碍。在这里，我们介绍了一种“用细菌欺骗细菌”的策略，该策略利用通过氯化钙处理和抗生素负荷改造的细菌，然后进行紫外线灭活。这些被修饰的细菌选择性地整合到同一物种的生物膜中，使局部pH和过氧化氢触发靶向生物膜内药物释放。物种特异性整合是必不可少的，因为不匹配的菌株由于表面粘附素和蛋白质谱的差异而表现出空间隔离。该策略对多种微生物生物膜有效，对金黄色葡萄球菌、大肠杆菌和白色念珠菌形成的生物膜均有效。它还通过诱导生物膜衍生的l-精氨酸的释放来激活生物膜相关的巨噬细胞，增强免疫反应。使用皮下和骨植入物感染模型进行的体内研究表明，与抗生素治疗相比，接受改良细菌治疗的动物的生物膜根除能力更强，免疫能力更长期，包括对再次感染的抵抗力。该方法可用于修饰患者感染相关细菌，以实现个性化生物膜内给药。

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引用次数: 0

A visually grounded language model for fetal ultrasound understanding 胎儿超声理解的视觉语言模型

IF 28.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-15 DOI: 10.1038/s41551-025-01578-3

Xiaoqing Guo, Mohammad Alsharid, He Zhao, Yipei Wang, Jayne Lander, Aris T. Papageorghiou, J. Alison Noble

Freehand fetal ultrasound examinations require substantial clinical skill. Here we propose Sonomate (mate of a sonographer), an AI assistant to a user during fetal ultrasound examinations. Sonomate is based on aligning video features and text features derived from transcribed audio to facilitate real-time interactions between an ultrasound machine and a user. Our approach combines coarse-grained video–text alignment with fine-grained image–sentence alignment to build a robust visually grounded language model capable of understanding fetal ultrasound videos. To tackle the challenges associated with heterogeneous language and asynchronous content in real-world video–audio pairs, we design the anatomy-aware alignment and context label correction in the fine-grained alignment. Sonomate is effective at anatomy detection in fetal ultrasound images without the need for retraining on manually annotated data. Furthermore, Sonomate shows promising performance in visual question answering for both fetal ultrasound images and videos. Guardrails are built to ensure the safety of Sonomate during deployment. This advancement paves the way towards AI-assistive technology being used to support sonography training and enhanced diagnostic capabilities.

徒手胎儿超声检查需要大量的临床技能。在这里，我们建议sononomate（超声医师的伴侣），在胎儿超声检查期间为用户提供人工智能助手。Sonomate是基于对齐视频特征和文本特征，从转录音频派生，以促进超声机器和用户之间的实时交互。我们的方法结合了粗粒度的视频文本对齐和细粒度的图像句子对齐，建立了一个健壮的视觉语言模型，能够理解胎儿超声视频。为了解决现实世界视频音频对中异构语言和异步内容带来的挑战，我们在细粒度对齐中设计了解剖学感知对齐和上下文标签校正。sononomate在胎儿超声图像解剖检测方面是有效的，而不需要对人工注释数据进行再训练。此外，sononomate在胎儿超声图像和视频的视觉问答中显示出有希望的性能。安装了护栏，确保Sonomate在部署过程中的安全。这一进步为人工智能辅助技术用于支持超声检查培训和增强诊断能力铺平了道路。

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引用次数: 0

Neural mechanisms underlying intracortical microstimulation for sensory restoration 皮层内微刺激对感觉恢复的神经机制。

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-15 DOI: 10.1038/s41551-025-01583-6

Christopher Hughes, Xing Chen, Warren Grill, Takashi D. Y. Kozai

Sensation plays a pivotal role in the orchestration of our daily lives. Intracortical microstimulation (ICMS) can elicit artificial sensations in persons who have lost sensation due to neurological injury or disease. Despite ongoing clinical studies to assess the safety and efficacy of ICMS, the mechanisms underlying neural activation by ICMS and their implications for perception are not well understood. This Review delves into the current understanding of ICMS mechanisms, drawing parallels with physiological sensory processing in the cortex. We explore emerging approaches and note challenges to current technologies, including resolution and the tissue response to electrode insertion. We conclude by highlighting the basic principles of ICMS, lingering questions and important focus areas for continued development. Intracortical microstimulation can elicit artificial sensations in persons who have lost sensation due to neurological injury or disease. This Review discusses intracortical microstimulation mechanisms, explores emerging approaches and notes challenges to current technologies.

感觉在我们日常生活的编排中扮演着关键的角色。皮质内微刺激（ICMS）可以引起由于神经损伤或疾病而失去感觉的人的人工感觉。尽管正在进行临床研究来评估ICMS的安全性和有效性，但ICMS激活神经的机制及其对感知的影响尚未得到很好的理解。这篇综述深入研究了目前对ICMS机制的理解，并将其与皮层的生理感觉处理进行了比较。我们探索新兴的方法，并注意到当前技术的挑战，包括分辨率和组织对电极插入的反应。最后，我们强调了ICMS的基本原则、遗留问题和继续发展的重点领域。

引用次数: 0

Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis. 间歇性低压诱导选择性衰老细胞死亡，缓解年龄相关性骨质疏松症。

IF 28.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-14 DOI: 10.1038/s41551-025-01584-5

Bowen Meng,Yan Qu,Benyi Yang,Chaoran Fu,Yifan He,Jing Li,Rentao Wan,Xin Li,Zhulin Xue,Zeyuan Cao,Meng Hao,Xiao Zhang,Zhe An,Fen Chen,Ruibao Ren,Xueli Mao,Yang Cao,Songtao Shi

Senescent cell accumulation contributes to aging, and their clearance represents an effective anti-aging strategy. Current senolytic strategies focus on drug-mediated senescent cell clearance, but it is unknown whether a hypobaric condition can induce senescent cell death. Here we show that hypobaric pressure (HP) at -375 mmHg without hypoxia induces cells to undergo lysosome-dependent cell death (LDCD). Mechanistically, we unveil that HP activates transmembrane protein 59 (TMEM59) to induce cellular Ca2+ influx, which triggers calpain 2 to cleave lysosomal associated membrane protein 2 (LAMP2), leading to lysosomal membrane permeabilization and subsequent LDCD. Furthermore, given that senescent cells contain elevated numbers of lysosomes, we report intermittent HP treatment to specifically induce senescent cells to undergo LDCD and reduce the senescence-associated secretory phenotype. Eventually, we report that intermittent HP treatment can substantially extend the lifespan and rescue the osteoporosis phenotype in aged mice. This study reveals a previously unknown role of HP as a natural senolytic to eliminate senescent cells, and identifies TMEM59 as a new HP-activated ion channel protein.

衰老细胞的积累有助于衰老，清除它们是一种有效的抗衰老策略。目前的抗衰老策略主要集中在药物介导的衰老细胞清除上，但尚不清楚低压条件是否能诱导衰老细胞死亡。本研究表明，无缺氧的-375 mmHg的低压（HP）诱导细胞发生溶酶体依赖性细胞死亡（LDCD）。在机制上，我们揭示了HP激活跨膜蛋白59 （TMEM59）诱导细胞Ca2+内流，从而触发calpain 2裂解溶酶体相关膜蛋白2 (LAMP2)，导致溶酶体膜通透性和随后的LDCD。此外，鉴于衰老细胞含有较高数量的溶酶体，我们报道间歇性HP治疗可特异性诱导衰老细胞进行LDCD并减少衰老相关的分泌表型。最后，我们报道间歇性HP治疗可以显著延长老年小鼠的寿命并挽救骨质疏松症表型。本研究揭示了HP作为一种天然抗衰老剂消除衰老细胞的未知作用，并确定TMEM59是一种新的HP激活离子通道蛋白。

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引用次数: 0

Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations. 基于数字crispr的耳念珠菌定量诊断和耐药突变。

IF 28.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-14 DOI: 10.1038/s41551-025-01597-0

Justin C Rolando,Anton Thieme,Nicole E Weckman,Nayoung Kim,Helena de Puig,Xiao Tan,Emily Cotnoir,Vishnu Chaturvedi,James J Collins,David R Walt

Candida auris, an increasingly prevalent fungal pathogen, requires both rapid identification and antifungal susceptibility testing to enable proper treatment. This study introduces digital SHERLOCK (dSHERLOCK), a platform that combines CRISPR/Cas nucleic acid detection, single-template quantification and real-time kinetics monitoring. Assays implemented on this platform display excellent sensitivity to C. auris from major clades 1-4, while maintaining specificity when challenged with common environmental and pathogenic fungi. dSHERLOCK detects C. auris within 20 min in minimally processed swab samples and achieves sensitive quantification (1 c.f.u. µl-1) within 40 min. To address antifungal susceptibility testing, we develop assays that detect mutations that are commonly associated with azole and echinocandin multidrug resistance. We use machine learning and real-time monitoring of reaction kinetics to achieve highly accurate simultaneous quantification of mutant and wild-type FKS1 SNP alleles in fungal populations with mixed antifungal susceptibility, which would be misdiagnosed as completely susceptible or resistant under standard reaction conditions. Our platform's use of commercially available materials and common laboratory equipment makes C. auris diagnostics widely deployable in global healthcare settings.

耳念珠菌是一种日益流行的真菌病原体，需要快速鉴定和抗真菌药敏试验才能进行适当治疗。本研究介绍了一种集CRISPR/Cas核酸检测、单模板定量和实时动力学监测于一体的数字SHERLOCK （dSHERLOCK）平台。在该平台上实施的检测对主要分支1-4的金黄色葡萄球菌显示出极好的敏感性，同时在常见环境和致病真菌的挑战下保持特异性。dSHERLOCK在最低限度处理的拭子样品中在20分钟内检测到金黄色葡萄球菌，并在40分钟内实现敏感定量（1 c.f.uµl-1）。为了解决抗真菌药敏测试，我们开发了检测通常与唑和棘白菌素多药耐药相关的突变的检测方法。我们利用机器学习和反应动力学的实时监测，在具有混合抗真菌敏感性的真菌群体中实现突变型和野生型FKS1 SNP等位基因的高精度同时定量，这些等位基因在标准反应条件下可能被误诊为完全敏感或耐药。我们的平台使用市售材料和普通实验室设备，使得auris诊断在全球卫生保健环境中得到广泛部署。

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引用次数: 0

A chemiluminescence assay targeting granzyme A activity for monitoring inflammatory bowel disease 一种针对颗粒酶A活性的化学发光试验用于监测炎症性肠病

IF 28.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-13 DOI: 10.1038/s41551-025-01588-1

Jamie I. Scott, Zhiming Cheng, Emily J. Thompson, Utsa Karmakar, Verity Cowell, Maya David, Doireann Gordon, Lorena Mendive-Tapia, Alexander Le Saint-Grant, Pia Volkmer, Cher S. Chuah, Phoebe Lau, Adriano G. Rossi, Wouter B. Nagengast, Doron Shabat, Gwo-Tzer Ho, Marc Vendrell

The diagnosis and monitoring of inflammatory bowel disease (IBD) relies on histologic and endoscopic analysis, as well as measurements of generic markers of inflammation. However, there are no specific tests that report on T cell-mediated immune responses as a key driver of IBD pathogenesis. Here we detect increasing granzyme A (GzmA) in gut biopsies and confirm that CD8+ T cells secrete its active form to induce interleukin (IL)-8. We then rationally design a non-invasive chemiluminescence assay for measuring active GzmA in stool supernatants from patients with IBD. For our assay, we synthesize peptide-based GzmA-specific inhibitors and chemiluminescent reporters and use them to characterize biosamples from ~150 human patients with IBD and healthy controls. Our results demonstrate that GzmA activity is an indicator of gut inflammation that can enhance the identification of patients with IBD over existing tests and potentially act as a mechanistic biomarker for the dominance of T cell activity. We envision that the selectivity and sensitivity of our GzmA activity-based optical assay will accelerate the design of additional biomedical approaches to enhance precision medicine in IBD.

炎症性肠病（IBD）的诊断和监测依赖于组织学和内窥镜分析，以及炎症的一般标记物的测量。然而，没有特异性的测试报告T细胞介导的免疫反应是IBD发病机制的关键驱动因素。在这里，我们检测到肠道活检中颗粒酶A （GzmA）的增加，并证实CD8+ T细胞分泌其活性形式来诱导白细胞介素(IL)-8。然后，我们合理地设计了一种无创化学发光法来测量IBD患者粪便上清液中的活性GzmA。在我们的实验中，我们合成了基于肽的gzma特异性抑制剂和化学发光报告因子，并使用它们来表征来自约150名IBD患者和健康对照的生物样品。我们的研究结果表明，GzmA活性是肠道炎症的一个指标，可以比现有的测试增强对IBD患者的识别，并可能作为T细胞活性优势的机制生物标志物。我们设想GzmA基于活性的光学检测的选择性和灵敏度将加速其他生物医学方法的设计，以增强IBD的精准医疗。

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引用次数: 0

Small intracellular vesicles outperform small extracellular vesicles in uptake, drug delivery and retinal neuroprotection 小细胞内囊泡优于小细胞外囊泡在摄取，药物传递和视网膜神经保护

IF 28.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-13 DOI: 10.1038/s41551-025-01596-1

Hui Zhang, Xinyue Yu, Fuhua Yang, Jinying An, Lin Su, Yuqing Liu, Mi Zhang, Ruiyan Fan, Hongli Yang, Xiaorong Li, Xiaomin Zhang

Small extracellular vesicles have been widely studied for their therapeutic properties and ability to deliver bioactive molecules. In addition to secretory vesicles, cells contain small intracellular vesicles involved in physiological and metabolic processes, whose therapeutic potential remains unexplored. Here we developed protocols to isolate small intracellular vesicles from multiple cell types and systematically compared their molecular and functional profiles to extracellular vesicles. Intracellular vesicles are smaller, yield higher quantities and demonstrate enhanced cellular uptake in both in vitro and in vivo models. Molecular profiling revealed that intracellular vesicles are enriched in proteins associated with the endoplasmic reticulum and Golgi apparatus, possess distinct microRNA signatures linked to intracellular membrane systems, and contain elevated levels of phospholipids such as phosphatidylcholine and phosphatidylethanolamine. Vesicles derived from umbilical cord mesenchymal stem cells showed superior therapeutic efficacy in a model of retinal degeneration by reducing endoplasmic reticulum stress and delivering neuroprotective factors. In addition, intracellular vesicles exhibited enhanced drug-loading capacity and efficient delivery of lipophilic compounds to the retina. These findings position intracellular vesicles as promising candidates for therapeutic applications.

细胞外小囊泡因其治疗特性和传递生物活性分子的能力而被广泛研究。除了分泌囊泡外，细胞内还含有参与生理和代谢过程的小细胞囊泡，其治疗潜力尚未开发。在这里，我们开发了从多种细胞类型中分离小细胞内囊泡的方案，并系统地比较了它们与细胞外囊泡的分子和功能特征。在体外和体内模型中，细胞内囊泡更小，产量更高，并且细胞摄取增强。分子分析显示，细胞内囊泡富含与内质网和高尔基体相关的蛋白质，具有与细胞膜系统相关的独特microRNA特征，并且含有高水平的磷脂，如磷脂酰胆碱和磷脂酰乙醇胺。来自脐带间充质干细胞的囊泡通过减少内质网应激和传递神经保护因子在视网膜变性模型中显示出优越的治疗效果。此外，细胞内囊泡表现出增强的药物装载能力和向视网膜有效传递亲脂化合物。这些发现使细胞内囊泡成为治疗应用的有希望的候选者。

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引用次数: 0

Real-time multimodal phenotyping reveals distinct tumour cell dynamics and immune escape mechanisms in T cell therapies. 实时多模态表型揭示了T细胞治疗中不同的肿瘤细胞动力学和免疫逃逸机制。

IF 28.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-12 DOI: 10.1038/s41551-025-01582-7

Shengjie Chen,Kunru Yu,Shengsen Zhang,Xiaoliang Guo,Rong Zhu

Adoptive T cell transfer therapy remains limited by the inability to monitor live tumour cell dynamics during treatment. Here we introduce a real-time, label-free phenotyping system that integrates electrical impedance spectroscopy, Raman spectroscopy and microscopy to analyse live tumour cells undergoing therapy. This system enables simultaneous tracking of metabolic activity, membrane integrity and cytoplasmic properties at single-cell resolution. First, analysis of glycolysis reveals that tumour-infiltrating lymphocytes suppress lactate production early, reducing tumour aggressiveness, while chimaeric antigen receptor T cells trigger tumour silent escape early and delay metabolic inhibition until later stages, culminating in cell death. Second, membrane profiling shows early phospholipid and cholesterol depletion under tumour-infiltrating lymphocyte treatment, with partial recovery, whereas chimaeric antigen receptor T cells cause progressive and irreversible membrane damage. Third, cytoplasmic analysis identifies early protein structural disruption and ionic imbalance under tumour-infiltrating lymphocyte therapy, while chimaeric antigen receptor T cells trigger delayed metabolic collapse and cytoplasmic contraction. These findings uncover distinct immune killing mechanisms and escape phases, offering mechanistic insights into tumour-immune interactions and informing the design of personalized therapeutic strategies.

过继性T细胞转移治疗仍然受到治疗期间无法监测活肿瘤细胞动力学的限制。在这里，我们介绍了一个实时的，无标签的表型系统，集成了电阻抗光谱，拉曼光谱和显微镜来分析正在接受治疗的活肿瘤细胞。该系统能够在单细胞分辨率下同时跟踪代谢活性，膜完整性和细胞质特性。首先，糖酵解分析表明，肿瘤浸润淋巴细胞早期抑制乳酸生成，降低肿瘤侵袭性，而嵌合抗原受体T细胞早期触发肿瘤沉默逃逸，延迟代谢抑制，直到后期，最终导致细胞死亡。其次，膜谱显示在肿瘤浸润性淋巴细胞治疗下早期磷脂和胆固醇消耗，部分恢复，而嵌合抗原受体T细胞导致进行性和不可逆的膜损伤。第三，细胞质分析确定肿瘤浸润淋巴细胞治疗下的早期蛋白质结构破坏和离子失衡，而嵌合抗原受体T细胞触发延迟代谢崩溃和细胞质收缩。这些发现揭示了不同的免疫杀伤机制和逃逸阶段，为肿瘤免疫相互作用提供了机制见解，并为个性化治疗策略的设计提供了信息。

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引用次数: 0

Wireless and bioresorbable triboelectric nerve block system for postoperative pain control. 无线和生物可吸收的摩擦电神经阻滞系统用于术后疼痛控制。

IF 28.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering

Pub Date : 2026-01-09 DOI: 10.1038/s41551-025-01579-2

Young-Jun Kim,So-Hee Kim,Byung-Joon Park,Jinyoung Jeon,Donghyeon Kang,Youngwook Chung,Joon-Ha Hwang,Hong-Joon Yoon,Kyu Hyoung Lee,Byung-Ok Choi,Sang-Woo Kim

Amidst the chronic issue of opioid misuse, finding an alternative to pharmaceutical pain control following surgical interventions stands as a major hurdle. Conventional non-pharmacological pain control technologies often rely on rigid stimulators linking internal and external body components, thereby imposing nerve burden and additional interventions for the removal. Here we introduce a bioresorbable triboelectric nerve cuff activated via ultrasounds for pain control. The targeted nerves are enveloped around polymers with opposite triboelectric properties that vibrate upon ultrasound stimulation, generating an alternating triboelectric field parallel to the nerve for pain modulation. In vivo testing in rat and porcine models demonstrates that the fully implanted neurostimulator exerts no discernible impact on gait and yields immediate pain relief. Application of the implant until full resorbing caused no adverse effects in the nerve or surrounding muscle tissue, and behavioural analysis confirmed its effective pain control. The implantable pain control system might offer a drug-free alternative to pain management strategies, helping prevent drug abuse.

在阿片类药物滥用的慢性问题中，寻找手术干预后药物疼痛控制的替代方案是一个主要障碍。传统的非药物疼痛控制技术通常依赖于连接身体内外部件的刚性刺激器，从而增加神经负担和额外的干预措施。在这里，我们介绍了一种生物可吸收的摩擦电神经套，通过超声波激活来控制疼痛。目标神经被包裹在具有相反摩擦电特性的聚合物周围，这些聚合物在超声刺激下振动，产生与神经平行的交替摩擦电场来调节疼痛。在大鼠和猪模型的体内测试表明，完全植入的神经刺激器对步态没有明显的影响，并能立即缓解疼痛。植入物的应用直到完全吸收对神经或周围肌肉组织没有不良影响，行为分析证实其有效控制疼痛。植入式疼痛控制系统可能为疼痛管理策略提供一种无药物替代方案，有助于防止药物滥用。

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引用次数: 0