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Metaverse in surgery — origins and future potential 外科中的元宇宙--起源与未来潜力
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-30 DOI: 10.1038/s41585-024-00941-4
Enrico Checcucci, Alessandro Veccia, Stefano Puliatti, Pieter De Backer, Pietro Piazza, Karl-Friedrich Kowalewski, Severin Rodler, Mark Taratkin, Ines Rivero Belenchon, Loic Baekelandt, Sabrina De Cillis, Alberto Piana, Ahmed Eissa, Juan Gomez Rivas, Giovanni Cacciamani, Francesco Porpiglia

The metaverse refers to a collective virtual space that combines physical and digital realities to create immersive, interactive environments. This space is powered by technologies such as augmented reality (AR), virtual reality (VR), artificial intelligence (AI) and blockchain. In healthcare, the metaverse can offer many applications. Specifically in surgery, potential uses of the metaverse include the possibility of conducting immersive surgical training in a VR or AR setting, and enhancing surgical planning through the adoption of three-dimensional virtual models and simulated procedures. At the intraoperative level, AR-guided surgery can assist the surgeon in real time to increase surgical precision in tumour identification and selective management of vessels. In post-operative care, potential uses of the metaverse include recovery monitoring and patient education. In urology, AR and VR have been widely explored in the past decade, mainly for surgical navigation in prostate and kidney cancer surgery, whereas only anecdotal metaverse experiences have been reported to date, specifically in partial nephrectomy. In the future, further integration of AI will improve the metaverse experience, potentially increasing the possibility of carrying out surgical navigation, data collection and virtual trials within the metaverse. However, challenges concerning data security and regulatory compliance must be addressed before the metaverse can be used to improve patient care.

元宇宙指的是一个集体虚拟空间,它将物理现实与数字现实相结合,创造出身临其境的互动环境。这个空间由增强现实(AR)、虚拟现实(VR)、人工智能(AI)和区块链等技术驱动。在医疗保健领域,元宇宙可以提供许多应用。具体到外科领域,元宇宙的潜在用途包括在 VR 或 AR 环境中进行沉浸式外科培训的可能性,以及通过采用三维虚拟模型和模拟程序增强外科规划的可能性。在术中层面,AR 引导的手术可以实时协助外科医生提高肿瘤识别和血管选择性管理的手术精确度。在术后护理方面,元宇宙的潜在用途包括恢复监测和患者教育。在泌尿外科领域,AR 和 VR 在过去十年中得到了广泛的探索,主要用于前列腺癌和肾癌手术的手术导航,而迄今为止,特别是在肾部分切除术方面,仅有关于元宇宙经验的轶事报道。未来,人工智能的进一步整合将改善元宇宙体验,有可能增加在元宇宙中进行手术导航、数据收集和虚拟试验的可能性。然而,在利用元宇宙改善患者护理之前,必须解决数据安全性和合规性方面的挑战。
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引用次数: 0
Electrical stimulation for the hypocontractile bladder 电刺激治疗收缩功能减退的膀胱
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-30 DOI: 10.1038/s41585-024-00949-w
Nima Nassiri, Lauren Schafrank, Michael Chen, Madeleine Burg, Victor Nitti
The incidence of detrusor underactivity is projected to rise owing to an ageing population and the increasing prevalence of diabetes, but therapeutic options remain limited. Successful bladder contractions have been yielded in studies of bladder pacing in animals. However, anatomical incongruities highlight the need for human trials. Bladder pacing in humans through electrical stimulation has shown some potential, although sustainable protocols are lacking owing to detrusor–sphincter dyssynergia and patient discomfort during trials. Thus, manometric studies in brain-dead patients might serve as a model for developing an implantable bladder pacing device to restore contractility.
由于人口老龄化和糖尿病发病率的增加,预计逼尿肌活动不足的发病率将上升,但治疗方案仍然有限。在动物膀胱起搏研究中,膀胱收缩取得了成功。然而,解剖学上的不协调凸显了人体试验的必要性。通过电刺激对人体进行膀胱起搏已显示出一定的潜力,但由于在试验过程中存在逼尿肌-括约肌协同障碍和患者不适,因此缺乏可持续的方案。因此,对脑死亡患者进行测压研究可作为开发植入式膀胱起搏装置以恢复收缩力的模型。
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引用次数: 0
Measuring and improving the cradle-to-grave environmental performance of urological procedures 衡量和改进泌尿外科手术从摇篮到坟墓的环境绩效
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-27 DOI: 10.1038/s41585-024-00937-0
Joseph B. John, William K. Gray, Tim W. R. Briggs, John S. McGrath

An urgent need for societal transformation exists to reduce the environmental impact of humanity, because environmental health affects human health. Health care causes ~5% of global greenhouse gas emissions and other substantial and ongoing environmental harms. Thus, health-care professionals and managers must lead ongoing efforts to improve the environmental performance of health systems. Life-cycle assessment (LCA) is a methodology that enables estimation of environmental impacts of products and processes. It models environmental effects from ‘cradle’ (raw material extraction) to ‘grave’ (end of useful life) and conventionally reports a range of different impact categories. LCA is a valuable tool when used appropriately. Maximizing its utility requires rational assumptions alongside careful consideration of system boundaries and data sources. Well-executed LCAs are detailed and transparently reported, enabling findings to be adapted or generalized to different settings. Attention should be given to modelling mitigation solutions in LCAs. This important step can guide health-care systems towards new and innovative solutions that embed progress towards international climate agreements. Many urological conditions are common, recurrent or chronic, requiring resource-intensive management with large associated environmental impacts. LCAs in urology have predominantly focussed on greenhouse gas emissions and have enabled identification of modifiable ‘hotspots’ including electricity use, travel, single-use items, irrigation, reprocessing and waste incineration. However, the methodological and reporting quality of published urology LCAs generally requires improvement and standardization. Health-care evaluation and commissioning frameworks that value LCA findings alongside clinical outcomes and cost could accelerate sustainable innovations. Rapid implementation strategies for known environmentally sustainable solutions are also needed.

由于环境健康会影响人类健康,因此迫切需要进行社会转型,以减少人类对环境的影响。医疗保健造成了全球约 5% 的温室气体排放和其他巨大且持续的环境危害。因此,医疗保健专业人员和管理人员必须不断努力,改善医疗保健系统的环境绩效。生命周期评估(LCA)是一种能够估算产品和流程对环境影响的方法。它模拟从 "摇篮"(原材料提取)到 "坟墓"(使用寿命结束)的环境影响,并按惯例报告一系列不同的影响类别。如果使用得当,生命周期评估是一种有价值的工具。要使其效用最大化,需要合理的假设,同时仔细考虑系统边界和数据来源。执行良好的生命周期评估报告内容详尽、透明,可将评估结果调整或推广到不同的环境中。应注意在生命周期评估中模拟减缓解决方案。这一重要步骤可引导医疗保健系统采用新的创新解决方案,从而在国际气候协议方面取得进展。许多泌尿科疾病是常见病、多发病或慢性病,需要进行资源密集型管理,对环境造成巨大影响。泌尿科的生命周期评估主要关注温室气体排放,并能识别可改变的 "热点",包括用电、旅行、一次性用品、灌溉、再处理和废物焚烧。然而,已发表的泌尿科生命周期评估的方法和报告质量普遍有待改进和标准化。医疗保健评估和委托框架在重视临床结果和成本的同时也重视生命周期评估结果,这将加速可持续创新。还需要为已知的环境可持续解决方案制定快速实施战略。
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引用次数: 0
Urinary bladder transplantation in humans - current status and future perspectives. 人类膀胱移植--现状与未来展望。
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-20 DOI: 10.1038/s41585-024-00935-2
Michał C Czarnogórski,Krzysztof Koper,Piotr Petrasz,Malte W Vetterlein,Marta Pokrywczyńska,Kajetan Juszczak,Tomasz Drewa,Jan Adamowicz
Urinary bladder vascularized allograft transplantation in humans is currently extensively being investigated worldwide, owing to the theoretical potential of this approach as a therapeutic option for individuals with end-stage, non-oncological bladder conditions or congenital bladder pathologies. To date, a successful attempt at urinary bladder autotransplantation was carried out in a heart-beating brain-dead research human donor. The robot-assisted surgical technique was shown to be optimal for performing this procedure, achieving a good performance in terms of both bladder allograft collection as well as vascular, ureterovesical and vesicourethral anastomoses. The urinary bladder vascularized allograft would be an alternative to traditional urinary diversion methods that rely on the use of intestinal segments, potentially avoiding adverse effects associated with these approaches. However, different from ileal urinary diversion, bladder transplantation would require lifelong immune suppression. Clinical trials are in progress to assess the vascularized bladder allograft transplantation technique, as well as the safety of this procedure in oncological and non-oncological indications.
膀胱血管同种异体移植目前正在全球范围内广泛开展研究,因为这种方法理论上有可能成为治疗晚期非肿瘤性膀胱疾病或先天性膀胱病变患者的一种选择。迄今为止,在一名心脏跳动的脑死亡研究人体捐献者身上成功尝试了膀胱自体移植。结果表明,机器人辅助手术技术是实施该手术的最佳选择,在膀胱同种异体移植物收集以及血管、输尿管和膀胱尿道吻合方面都取得了良好的效果。膀胱血管化同种异体移植可替代依赖使用肠段的传统尿路转流方法,可能避免与这些方法相关的不良影响。不过,与回肠尿路转流不同,膀胱移植需要终生免疫抑制。目前正在进行临床试验,以评估血管化膀胱同种异体移植技术以及这种手术在肿瘤和非肿瘤适应症中的安全性。
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引用次数: 0
Gut microbiota influence bladder tumour development 肠道微生物群影响膀胱肿瘤的发展
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-16 DOI: 10.1038/s41585-024-00947-y
Louise Lloyd
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引用次数: 0
Prescribing clinician specialty influences adherence to PrEP 开处方的临床医生专业影响 PrEP 的依从性
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00945-0
Maria Chiara Masone
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引用次数: 0
piRNA pathway disruption in human infertility 人类不孕症中的 piRNA 通路干扰
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00946-z
Maria Chiara Masone
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引用次数: 0
A wearable UBVM device to monitor bladder volume 监测膀胱容量的可穿戴 UBVM 设备
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00944-1
Maria Chiara Masone
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引用次数: 0
Intralesional heterogeneity on PSMA PET–CT predicts mCRPC outcomes PSMA PET-CT 显示的区域内异质性可预测 mCRPC 的预后
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-13 DOI: 10.1038/s41585-024-00943-2
Maria Chiara Masone
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引用次数: 0
AI in prostate MRI: enhancing accuracy and reducing overdiagnosis 前列腺磁共振成像中的人工智能:提高准确性并减少过度诊断
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY Pub Date : 2024-09-11 DOI: 10.1038/s41585-024-00940-5
Baris Turkbey
Artificial intelligence can be leveraged to improve the detection of prostate cancer on magnetic resonance imaging; however, before this technology is implemented in clinical practice, further research is required.
人工智能可用于改善磁共振成像对前列腺癌的检测;然而,在这项技术应用于临床实践之前,还需要进一步的研究。
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引用次数: 0
期刊
Nature Reviews Urology
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