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Virtual reality for nephrolithotomy 虚拟现实用于肾镜取石术
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-12-11 DOI: 10.1038/s41585-024-00990-9
Isobel Leake
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引用次数: 0
The mechanism of action of neuromodulation in the treatment of overactive bladder 神经调节治疗膀胱过动症的作用机制
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-12-09 DOI: 10.1038/s41585-024-00967-8
Jan Krhut, Hanne Kobberø, Reine Kanaan, Mikkel Fode, Mads Poulsen, Peter Zvara

Neuromodulation has been used in the treatment of various pelvic organ dysfunctions for almost 40 years and several placebo-controlled studies have confirmed its clinical effect. Many neuromodulation methods using different devices and stimulation parameters, targeting different neural structures have been introduced, but only a limited number have been adopted into routine clinical use. A substantial volume of basic research and clinical studies addressing specific effects of neuromodulation in the treatment of overactive bladder (OAB) have been published to date; however, their mechanistic implications have not been comprehensively summarized. Thus, our understanding of the mechanism of action of neuromodulation in OAB treatment is mainly based on postulated theories. Results from animal experiments suggest that different neuromodulation methods used to treat OAB share the same basic principles. The most likely explanation for the effect of neuromodulation in OAB therapy is the suppression of bladder afferent signalling, promotion of spinal guarding reflexes and modulation of non-specific supraspinal regulatory circuits.

神经调节用于治疗各种盆腔器官功能障碍已有近40年的历史，一些安慰剂对照研究证实了其临床效果。许多神经调节方法采用不同的装置和刺激参数，针对不同的神经结构已经被介绍，但只有有限的数量已被纳入常规临床应用。迄今为止，已经发表了大量的基础研究和临床研究，讨论了神经调节在治疗膀胱过动症（OAB）中的特定作用；然而，它们的机制含义尚未得到全面总结。因此，我们对OAB治疗中神经调节作用机制的理解主要基于假设理论。动物实验结果表明，用于治疗OAB的不同神经调节方法具有相同的基本原理。对于OAB治疗中神经调节的作用，最可能的解释是抑制膀胱传入信号，促进脊髓保护反射和调节非特异性棘上调节回路。
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引用次数: 0
Serial ctDNA to understand PARPi resistance 序列ctDNA了解PARPi抗性
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-12-09 DOI: 10.1038/s41585-024-00984-7
Annette Fenner
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引用次数: 0
PFOA affects androgen metabolism 全氟辛酸影响雄激素代谢
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00985-6
Louise Lloyd
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引用次数: 0
PEACEing together prostate cancer therapy 和平共处前列腺癌治疗
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00982-9
Louise Lloyd
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引用次数: 0
JAK–STAT signalling and prostate basal cell fate JAK-STAT信号与前列腺基底细胞的命运
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00983-8
Louise Lloyd
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引用次数: 0
Better PrEParation for HIV prevention in minority groups 加强对少数群体艾滋病毒预防的准备
IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-12-06 DOI: 10.1038/s41585-024-00981-w
Louise Lloyd
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引用次数: 0
Robot-assisted radical prostatectomy haemostasis techniques and outcomes 机器人辅助根治性前列腺切除术止血技术及结果
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-12-05 DOI: 10.1038/s41585-024-00978-5
Gal Wald, Joshua Winograd, Mark Farha, Vanessa Dudley, Jim C. Hu
The robot-assisted approach to radical prostatectomy has enabled same-day discharge. A substantial concern associated with this practice could be haemorrhage, but sound and thorough robot-assisted radical prostatectomy haemostasis surgical techniques that were introduced to prevent bleeding mitigate this phenomenon.
机器人辅助的根治性前列腺切除术实现了当日出院。与此相关的一个重要问题可能是出血，但引入了健全和彻底的机器人辅助根治性前列腺切除术止血手术技术来预防出血，减轻了这种现象。
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引用次数: 0
Advancing the state of the art in congenital obstructive uropathy 推进先天性梗阻性尿路病变的最新进展
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-11-29 DOI: 10.1038/s41585-024-00976-7
Ashley R. Jackson, Nathalia G. Amado, Nina Mann, Joost P. Schanstra, Rodrigo Ruano, Tahagod Mohamed, Richard S. Lee, Armando Lorenzo, Daryl McLeod, Brian Becknell
In March 2024, we convened a symposium to consider the state of the art regarding the mechanisms and management of congenital obstructive uropathy caused by bladder outlet obstruction, at which overarching themes emerged and opportunities for research were discussed to fill key knowledge gaps in achieving the best future for children with congenital obstructive uropathy.
2024年3月，我们召开了一次研讨会，讨论由膀胱出口梗阻引起的先天性梗阻性尿病的机制和治疗的最新进展，会上出现了总体主题，讨论了研究机会，以填补先天性梗阻性尿病儿童实现最佳未来的关键知识空白。
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引用次数: 0
Time is on our side — rethinking the concept of time to treatment for prostate cancer 时间站在我们这一边——重新思考前列腺癌治疗的时间概念
IF 15.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Nature Reviews Urology
Pub Date : 2024-11-29 DOI: 10.1038/s41585-024-00977-6
Nynikka R. Palmer, Peter R. Carroll, Samuel L. Washington
Prostate cancer is often an indolent disease, and delays in treatment up to 6 months do not seem to affect cancer-free survival. Inadequate pre-treatment assessment and uninformed shared decision-making can lead to decision regret and disparities in receipt of treatments. Time is on our side to allocate sufficient time and resources to consider the most appropriate and individualized treatment decision in prostate cancer care.
前列腺癌通常是一种惰性疾病，延迟治疗长达6个月似乎不会影响无癌生存。不充分的治疗前评估和不知情的共同决策可能导致决定后悔和接受治疗的差异。我们有足够的时间和资源来考虑前列腺癌护理中最合适和最个性化的治疗决策。
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引用次数: 0
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