Pub Date : 2026-01-06DOI: 10.1038/s41585-025-01116-5
Arthur L. Burnett, Mikael N. Sturny, Anthony J. Costello, Philip Dundee, Sidney Glina, Nikolaos Stergiopoulos, Rodrigo A. Fraga-Silva
{"title":"Implantable pelvic neurostimulators to restore erectile function: from concept to practice","authors":"Arthur L. Burnett, Mikael N. Sturny, Anthony J. Costello, Philip Dundee, Sidney Glina, Nikolaos Stergiopoulos, Rodrigo A. Fraga-Silva","doi":"10.1038/s41585-025-01116-5","DOIUrl":"https://doi.org/10.1038/s41585-025-01116-5","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"40 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1038/s41585-025-01113-8
Marieke Dewitte, Charmaine Borg
{"title":"Rethinking sexual pleasure in research, health care and society","authors":"Marieke Dewitte, Charmaine Borg","doi":"10.1038/s41585-025-01113-8","DOIUrl":"https://doi.org/10.1038/s41585-025-01113-8","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"1 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1038/s41585-025-01117-4
Michael V Ortiz, Francis S P L Wens, Andrew L Hong, Paola Quarello, Arnauld C Verschuur, Elisabeth T Tracy, Najat C Daw, Jeffrey S Dome, Amy L Walz, Julia Sprokkerieft, Godelieve A M Tytgat, Alex Kentsis, Jaime Libes-Bander, Peter J Schoettler, Daniela Perotti, Jarno Drost, Rajkumar Venkatramani, James I Geller, Marry M van den Heuvel-Eibrink
Paediatric kidney tumours are generally associated with a favourable survival rate. Most children are diagnosed with Wilms tumour, which has a 90% long-term survival rate with conventional front-line and salvage therapies. However, treatments and outcomes of children with relapsed non-Wilms tumours, such as malignant rhabdoid tumour of the kidney, renal-cell carcinoma (including renal medullary carcinoma), clear-cell sarcoma of the kidney, anaplastic sarcoma of the kidney and congenital mesoblastic nephroma are not well defined. Several of these non-Wilms tumours include unfavourable prognostic subtypes. Currently available data on non-Wilms tumours support advancing studies that pivot from conventional strategies towards disease-specific, biologically driven novel treatments to improve outcomes for each of these rare childhood kidney tumours.
{"title":"Relapsed rhabdoid tumours and other non-nephroblastoma childhood and adolescent kidney tumours: perspectives from the HARMONICA collaboration.","authors":"Michael V Ortiz, Francis S P L Wens, Andrew L Hong, Paola Quarello, Arnauld C Verschuur, Elisabeth T Tracy, Najat C Daw, Jeffrey S Dome, Amy L Walz, Julia Sprokkerieft, Godelieve A M Tytgat, Alex Kentsis, Jaime Libes-Bander, Peter J Schoettler, Daniela Perotti, Jarno Drost, Rajkumar Venkatramani, James I Geller, Marry M van den Heuvel-Eibrink","doi":"10.1038/s41585-025-01117-4","DOIUrl":"https://doi.org/10.1038/s41585-025-01117-4","url":null,"abstract":"<p><p>Paediatric kidney tumours are generally associated with a favourable survival rate. Most children are diagnosed with Wilms tumour, which has a 90% long-term survival rate with conventional front-line and salvage therapies. However, treatments and outcomes of children with relapsed non-Wilms tumours, such as malignant rhabdoid tumour of the kidney, renal-cell carcinoma (including renal medullary carcinoma), clear-cell sarcoma of the kidney, anaplastic sarcoma of the kidney and congenital mesoblastic nephroma are not well defined. Several of these non-Wilms tumours include unfavourable prognostic subtypes. Currently available data on non-Wilms tumours support advancing studies that pivot from conventional strategies towards disease-specific, biologically driven novel treatments to improve outcomes for each of these rare childhood kidney tumours.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1038/s41585-025-01115-6
Suma Gangidi,Gal Wald,Jim C Hu
{"title":"Technical modifications to improve erectile function recovery after radical prostatectomy.","authors":"Suma Gangidi,Gal Wald,Jim C Hu","doi":"10.1038/s41585-025-01115-6","DOIUrl":"https://doi.org/10.1038/s41585-025-01115-6","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"55 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145704319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1038/s41585-025-01118-3
Louise Lloyd
{"title":"Och AI the noo from SIU","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01118-3","DOIUrl":"10.1038/s41585-025-01118-3","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"23 1","pages":"8-8"},"PeriodicalIF":14.6,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-27DOI: 10.1038/s41585-025-01111-w
Melis Guer, Wayne G. Brisbane, Hannes Cash, Sangeet Ghai, Laurence Klotz, Paul F. R. Wilson, Adam Kinnaird
{"title":"Micro-ultrasound for prostate cancer","authors":"Melis Guer, Wayne G. Brisbane, Hannes Cash, Sangeet Ghai, Laurence Klotz, Paul F. R. Wilson, Adam Kinnaird","doi":"10.1038/s41585-025-01111-w","DOIUrl":"https://doi.org/10.1038/s41585-025-01111-w","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"119 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41585-025-01114-7
Rui M Bernardino, João Lobo, Jihad Kaouk, Theodorus van der Kwast, Susan Prendeville, Fabio Zattoni, Lorenzo Bianchi, Alberto Martini, Pawel Rajwa, Veeru Kasivisvanathan, Giancarlo Marra, Neil Fleshner
{"title":"Author Correction: Atypical intraductal proliferation in prostate biopsy - a diagnostic grey zone with clinical implications.","authors":"Rui M Bernardino, João Lobo, Jihad Kaouk, Theodorus van der Kwast, Susan Prendeville, Fabio Zattoni, Lorenzo Bianchi, Alberto Martini, Pawel Rajwa, Veeru Kasivisvanathan, Giancarlo Marra, Neil Fleshner","doi":"10.1038/s41585-025-01114-7","DOIUrl":"https://doi.org/10.1038/s41585-025-01114-7","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":" ","pages":""},"PeriodicalIF":14.6,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145541426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1038/s41585-025-01109-4
Maddison L Graffeo,Jessica E M Dunleavy,Brendan J Houston,Moira K O'Bryan
The sperm tail is a modified motile cilium analogous to those found in tissues including the lung and brain. They have been evolutionarily sculpted to optimize motility and, therefore, fertility, through the dynamic and challenging environment of the female reproductive tract. Sperm tails are composed of three structurally distinct regions: the midpiece, the principal piece and the end piece. The most proximal region - the midpiece - is surrounded by a mitochondrial sheath, which has been proposed to provide structural integrity and ATP as fuel for sperm tail movement. Despite the main phases of mitochondrial sheath assembly being described, the specific biological mechanisms that underpin its formation and maturation remain poorly defined and, in many cases, unknown. Moreover, emerging evidence has highlighted that the precise contribution of the mitochondrial sheath to energy production in sperm has been misunderstood. ATP generation via glycolysis and mitochondrial respiration, previously believed to be physically uncoupled, engage in crosstalk to maximize sperm function, competition and overall fertility. Understanding these processes could not only provide vital insights into the aetiology of male infertility and offer targets for contraceptive development but could also provide insights into mechanisms of relevance to other tissues in which mitochondrial dynamics is challenging to monitor.
{"title":"Sperm mitochondrial sheath formation - how and why?","authors":"Maddison L Graffeo,Jessica E M Dunleavy,Brendan J Houston,Moira K O'Bryan","doi":"10.1038/s41585-025-01109-4","DOIUrl":"https://doi.org/10.1038/s41585-025-01109-4","url":null,"abstract":"The sperm tail is a modified motile cilium analogous to those found in tissues including the lung and brain. They have been evolutionarily sculpted to optimize motility and, therefore, fertility, through the dynamic and challenging environment of the female reproductive tract. Sperm tails are composed of three structurally distinct regions: the midpiece, the principal piece and the end piece. The most proximal region - the midpiece - is surrounded by a mitochondrial sheath, which has been proposed to provide structural integrity and ATP as fuel for sperm tail movement. Despite the main phases of mitochondrial sheath assembly being described, the specific biological mechanisms that underpin its formation and maturation remain poorly defined and, in many cases, unknown. Moreover, emerging evidence has highlighted that the precise contribution of the mitochondrial sheath to energy production in sperm has been misunderstood. ATP generation via glycolysis and mitochondrial respiration, previously believed to be physically uncoupled, engage in crosstalk to maximize sperm function, competition and overall fertility. Understanding these processes could not only provide vital insights into the aetiology of male infertility and offer targets for contraceptive development but could also provide insights into mechanisms of relevance to other tissues in which mitochondrial dynamics is challenging to monitor.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"110 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-10DOI: 10.1038/s41585-025-01107-6
Sola Adeleke, Joao R. Galante, Yishen Wang, Gurdip Azad, Simon Wan, Athar Haroon, Diletta Bianchini, Jamshed Bomanji, Michael S. Hofman, Travis S. Young, Gary J. R. Cook
{"title":"Emerging evidence for sequencing and combining PSMA-based therapies in prostate cancer","authors":"Sola Adeleke, Joao R. Galante, Yishen Wang, Gurdip Azad, Simon Wan, Athar Haroon, Diletta Bianchini, Jamshed Bomanji, Michael S. Hofman, Travis S. Young, Gary J. R. Cook","doi":"10.1038/s41585-025-01107-6","DOIUrl":"https://doi.org/10.1038/s41585-025-01107-6","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"2 1","pages":""},"PeriodicalIF":15.3,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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