Pub Date : 2025-04-29DOI: 10.1038/s41585-025-01038-2
Maetal E. Haas Kogan, Barbara Chubak, Elizabeth R. Boskey, Steven J. Staffa, Carl G. Streed Jr, Katharine B. Dalke, Arlene Baratz, Cecile Ferrando, Frances W. Grimstad
The surgical care of patients with differences in sex development (DSD) or intersex traits has historically been the domain of paediatric subspecialties. However, as patients defer surgeries until later in life, providers are needed to help close this emerging clinical care gap for the LGBTQIA+ community.
{"title":"Reconstructive urologists can address the care gap for adults with intersex traits","authors":"Maetal E. Haas Kogan, Barbara Chubak, Elizabeth R. Boskey, Steven J. Staffa, Carl G. Streed Jr, Katharine B. Dalke, Arlene Baratz, Cecile Ferrando, Frances W. Grimstad","doi":"10.1038/s41585-025-01038-2","DOIUrl":"10.1038/s41585-025-01038-2","url":null,"abstract":"The surgical care of patients with differences in sex development (DSD) or intersex traits has historically been the domain of paediatric subspecialties. However, as patients defer surgeries until later in life, providers are needed to help close this emerging clinical care gap for the LGBTQIA+ community.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 6","pages":"330-331"},"PeriodicalIF":14.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-25DOI: 10.1038/s41585-025-01028-4
Yu-Hsiang Lin, Kuo-Jen Lin, Chun-Te Wu
{"title":"Revisiting the complex interactions in nocturnal polyuria: insights on OSA, ADH and ANP","authors":"Yu-Hsiang Lin, Kuo-Jen Lin, Chun-Te Wu","doi":"10.1038/s41585-025-01028-4","DOIUrl":"10.1038/s41585-025-01028-4","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 10","pages":"720-721"},"PeriodicalIF":14.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-25DOI: 10.1038/s41585-025-01027-5
Olaf P. J. Vrooman, Mohammad S. Rahnama’i
{"title":"Reply to ‘Revisiting the complex interactions in nocturnal polyuria: insights on OSA, ADH and ANP’","authors":"Olaf P. J. Vrooman, Mohammad S. Rahnama’i","doi":"10.1038/s41585-025-01027-5","DOIUrl":"10.1038/s41585-025-01027-5","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 10","pages":"722-722"},"PeriodicalIF":14.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-15DOI: 10.1038/s41585-025-01023-9
Sia V. Lindskrog, Trine Strandgaard, Iver Nordentoft, Matthew D. Galsky, Thomas Powles, Mads Agerbæk, Jørgen Bjerggaard Jensen, Catherine Alix-Panabières, Lars Dyrskjøt
Liquid biopsies, indicating the sampling of body fluids rather than solid-tissue biopsies, have the potential to revolutionize cancer care through personalized, noninvasive disease detection and monitoring. Circulating tumour DNA (ctDNA) and circulating tumour cells (CTCs) are promising blood-based biomarkers in bladder cancer. Results from several studies have shown the clinical potential of ctDNA and CTCs in bladder cancer for prognostication, treatment-response monitoring, and early detection of minimal residual disease and disease recurrence. Following successful clinical trial evaluation, assessment of ctDNA and CTCs holds the potential to transform the therapeutic pathway for patients with bladder cancer — potentially in combination with the analysis of urinary tumour DNA — through tailored treatment guidance and optimized disease surveillance. In this Review, the authors provide an overview of circulating tumour DNA and circulating tumour cells as potential biomarkers to provide therapeutic guidance and optimize disease surveillance in bladder cancer. Challenges associated with these biomarkers and future perspectives for clinical implementation are also discussed.
{"title":"Circulating tumour DNA and circulating tumour cells in bladder cancer — from discovery to clinical implementation","authors":"Sia V. Lindskrog, Trine Strandgaard, Iver Nordentoft, Matthew D. Galsky, Thomas Powles, Mads Agerbæk, Jørgen Bjerggaard Jensen, Catherine Alix-Panabières, Lars Dyrskjøt","doi":"10.1038/s41585-025-01023-9","DOIUrl":"10.1038/s41585-025-01023-9","url":null,"abstract":"Liquid biopsies, indicating the sampling of body fluids rather than solid-tissue biopsies, have the potential to revolutionize cancer care through personalized, noninvasive disease detection and monitoring. Circulating tumour DNA (ctDNA) and circulating tumour cells (CTCs) are promising blood-based biomarkers in bladder cancer. Results from several studies have shown the clinical potential of ctDNA and CTCs in bladder cancer for prognostication, treatment-response monitoring, and early detection of minimal residual disease and disease recurrence. Following successful clinical trial evaluation, assessment of ctDNA and CTCs holds the potential to transform the therapeutic pathway for patients with bladder cancer — potentially in combination with the analysis of urinary tumour DNA — through tailored treatment guidance and optimized disease surveillance. In this Review, the authors provide an overview of circulating tumour DNA and circulating tumour cells as potential biomarkers to provide therapeutic guidance and optimize disease surveillance in bladder cancer. Challenges associated with these biomarkers and future perspectives for clinical implementation are also discussed.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 9","pages":"590-608"},"PeriodicalIF":14.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-14DOI: 10.1038/s41585-025-01036-4
Annette Fenner
{"title":"Madrid plays host to a celebration of urology","authors":"Annette Fenner","doi":"10.1038/s41585-025-01036-4","DOIUrl":"10.1038/s41585-025-01036-4","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 5","pages":"253-253"},"PeriodicalIF":14.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-14DOI: 10.1038/s41585-025-01037-3
Annette Fenner
{"title":"Sexual transfer of bacteria for forensic use","authors":"Annette Fenner","doi":"10.1038/s41585-025-01037-3","DOIUrl":"10.1038/s41585-025-01037-3","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 5","pages":"253-253"},"PeriodicalIF":14.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-14DOI: 10.1038/s41585-025-01035-5
Jax Whitehead, Marissa Adams, Adam Davies, Emilie K. Johnson, Louise Tucker C. Pyle
Medical terminology requires periodic updates based on the input of affected communities and/or to reflect advances in scientific understanding. An update to terminology to replace the terms ‘ambiguous’ and ‘atypical’ as descriptors of external genital anatomy in the intersex, variations of sex characteristics and differences of sex development (i/VSC/DSD) field could be an important step forwards in the field.
{"title":"Evolving language reflects evolving understanding: updated terms for anatomical description in i/VSC/DSD","authors":"Jax Whitehead, Marissa Adams, Adam Davies, Emilie K. Johnson, Louise Tucker C. Pyle","doi":"10.1038/s41585-025-01035-5","DOIUrl":"10.1038/s41585-025-01035-5","url":null,"abstract":"Medical terminology requires periodic updates based on the input of affected communities and/or to reflect advances in scientific understanding. An update to terminology to replace the terms ‘ambiguous’ and ‘atypical’ as descriptors of external genital anatomy in the intersex, variations of sex characteristics and differences of sex development (i/VSC/DSD) field could be an important step forwards in the field.","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 6","pages":"332-333"},"PeriodicalIF":14.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-09DOI: 10.1038/s41585-025-01034-6
Maria Chiara Masone
{"title":"Neural control of male sexual behaviours","authors":"Maria Chiara Masone","doi":"10.1038/s41585-025-01034-6","DOIUrl":"10.1038/s41585-025-01034-6","url":null,"abstract":"","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"22 5","pages":"254-254"},"PeriodicalIF":14.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143814346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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