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Repository corticotropin injection improves quality metrics in an observational study of multiple sclerosis relapse. 储存库促肾上腺皮质激素注射改善了多发性硬化症复发的观察性研究的质量指标。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-12-01 Epub Date: 2021-12-03 DOI: 10.2217/nmt-2021-0030
Jeffrey Kaplan, Tamara Miller, Matthew Baker, Bryan Due, Enxu Zhao

Aim: To determine whether clinicians evaluate American Academy of Neurology (AAN) quality metrics for patients with multiple sclerosis (MS) relapse and whether repository corticotropin injection (RCI) improves clinical and patient-reported outcomes associated with these metrics at 2 and 6 months after treatment. Methods: A multicenter, prospective, observational registry evaluating patients receiving RCI for MS relapse (N = 125) categorized data according to AAN quality metrics involving diagnosis, disability, fatigue, cognitive impairment, depression, and quality of life. Results: Clinicians assessed all 11 AAN quality metrics in patients with MS relapse. Disability, fatigue, cognitive impairment, depression, and quality of life outcomes improved with RCI therapy. Conclusion: RCI was associated with improved quality metrics, and AAN guidelines were followed during routine RCI treatment for MS relapse.

目的:确定临床医生是否评估美国神经病学学会(AAN)多发性硬化症(MS)复发患者的质量指标,以及储存库促肾上腺皮质激素注射(RCI)是否在治疗后2个月和6个月改善与这些指标相关的临床和患者报告的结果。方法:一项多中心、前瞻性、观察性注册研究,评估接受RCI治疗多发性硬化复发的患者(N = 125),根据AAN质量指标分类数据,包括诊断、残疾、疲劳、认知障碍、抑郁和生活质量。结果:临床医生评估了MS复发患者的所有11个AAN质量指标。残障、疲劳、认知障碍、抑郁和生活质量通过RCI治疗得到改善。结论:RCI与改善的质量指标相关,在MS复发的常规RCI治疗中遵循AAN指南。
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引用次数: 2
Tongue measurements and pharyngeal residue in amyotrophic lateral sclerosis. 肌萎缩性侧索硬化症患者的舌头测量和咽残液。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-12-01 Epub Date: 2021-11-08 DOI: 10.2217/nmt-2021-0027
Milena Magalhães Augusto, Roberta Gonçalves da Silva, Mario Emílio Teixeira Dourado Júnior, Juliana Fernandes Godoy, Leonardo Wanderley Lopes, Leandro Pernambuco

Aim: We aimed to analyze the relationship between tongue measurements and vallecular residue in patients with amyotrophic lateral sclerosis (ALS). Materials & methods: Twenty-one patients with ALS were assessed for posterior maximum tongue isometric pressure (PMTIP) and posterior tongue isometric endurance (PTIE) by the Iowa Oral Performance Instrument; vallecular residue after 10 ml of moderately thickened consistency by Fiberoptic Endoscopic Evaluation of Swallowing; and tongue thickness (TT) by ultrasonography. Results: PMTIP, PTIE and TT were decreased compared with the reference values for healthy individuals and were not different between patients with and without vallecular residue. Conclusion: In ALS, PMTIP, PTIE and TT are not good predictors of vallecular residue in the tested volume and food consistency.

目的:分析肌萎缩性侧索硬化症(ALS)患者舌廓尺寸与瓣膜残留的关系。材料与方法:采用爱荷华口腔性能仪对21例ALS患者进行舌后最大等距压力(PMTIP)和舌后等距耐力(PTIE)评估;10 ml中等增厚稠度后的小静脉残留纤维内镜吞咽评价;舌厚(TT)。结果:与健康人的参考值相比,ptip、PTIE和TT均有所降低,存在和不存在瓣膜残留的患者间无差异。结论:在ALS中,PMTIP、PTIE和TT不能很好地预测被测体积和食物稠度中的静脉残留。
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引用次数: 2
Sporadic Huntington's disease in the Philippines: a case report. 菲律宾散发性亨廷顿舞蹈病1例报告。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-12-01 Epub Date: 2021-11-17 DOI: 10.2217/nmt-2021-0023
Laurence Kristoffer J Batino, John Hiyadan, Debbie Liquete, Manolo Flores

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder with core clinical features of choreoathetosis, cognitive deficits and behavioral changes. It is a rare disorder, primarily affecting the Caucasian population, and rarely Asians. To date, there are only two reported, genetically proven familial HD cases in the Philippines. We present the case of a 39-year-old Filipino male with a 10-year history of progressive behavior and personality changes followed by cognitive decline and choreoathetotic movements. Neuroimaging showed atrophy of both caudate and putamen with putaminal rim sign. Genetic testing revealed a 47 CAG trinucleotide repeats in the Huntingtin gene; family history is negative. This is the first, genetically proven, sporadic and the third HD case in the Philippines. Despite its rarity, this report highlights the importance of including HD as a possible cause of adult-onset chorea among Filipinos.

亨廷顿舞蹈病(HD)是一种常染色体显性神经退行性疾病,其核心临床特征为舞蹈病、认知缺陷和行为改变。这是一种罕见的疾病,主要影响白种人,很少影响亚洲人。迄今为止,菲律宾仅报告了两例经基因证实的家族性HD病例。我们报告一名39岁菲律宾男性的病例,他有10年的进行性行为和人格改变史,随后出现认知能力下降和舞蹈运动失调。神经影像学显示尾状核及壳核萎缩伴壳核边缘征。基因检测显示亨廷顿基因中有47个CAG三核苷酸重复;家族史为阴性。这是菲律宾第一例经基因证实的散发性疟疾病例,也是第三例。尽管罕见,本报告强调了将HD作为菲律宾成人发病舞蹈病可能原因的重要性。
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引用次数: 0
The remote assessment of parkinsonism supporting the ongoing development of interventions in Gaucher disease. 帕金森病的远程评估支持戈谢病干预措施的持续发展。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-12-01 Epub Date: 2021-10-20 DOI: 10.2217/nmt-2021-0032
Abigail Louise Higgins, Marco Toffoli, Stephen Mullin, Chiao-Yin Lee, Sofia Koletsi, Micol Avenali, Fabio Blandini, Anthony Hv Schapira

Mutations in GBA which are causative of Gaucher disease in their biallelic form, are the most common genetic risk factor for Parkinson's disease (PD). The diagnosis of PD relies upon clinically defined motor features which appear after irreversible neurodegeneration. Prodromal symptoms of PD may provide a means to predict latent pathology, years before the onset of motor features. Previous work has reported prodromal features of PD in GBA mutation carriers, however this has been insufficiently sensitive to identify those that will develop PD. The Remote Assessment of Parkinsonism Supporting Ongoing Development of Interventions in Gaucher Disease (RAPSODI GD) study assesses a large cohort of GBA mutation carriers, to aid development of procedures for earlier diagnosis of PD.

GBA突变以双等位基因形式导致戈谢病,是帕金森病(PD)最常见的遗传危险因素。PD的诊断依赖于不可逆神经变性后出现的临床定义的运动特征。PD的前驱症状可能提供了一种预测潜伏病理的手段,在运动特征发生前几年。先前的研究报道了GBA突变携带者的PD前驱特征,然而,这对于识别那些将发展为PD的人来说还不够敏感。支持戈谢病干预措施持续发展的帕金森病远程评估(RAPSODI GD)研究评估了一大群GBA突变携带者,以帮助开发PD的早期诊断程序。
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引用次数: 2
Unmet needs and evolving treatment for limb girdle muscular dystrophies. 肢带肌营养不良症的未满足需求和不断发展的治疗方法。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-10-01 Epub Date: 2021-09-02 DOI: 10.2217/nmt-2020-0066
Eric Pozsgai, Danielle Griffin, Rachael Potter, Zarife Sahenk, Kelly Lehman, Louise R Rodino-Klapac, Jerry R Mendell

Limb-girdle muscular dystrophies (LGMDs) represent a major group of muscle disorders. Treatment is sorely needed and currently expanding based on safety and efficacy adopting principles of single-dosing gene therapy for monogenic autosomal recessive disorders. Gene therapy has made in-roads for LGMD and this review describes progress that has been achieved for these conditions. This review first provides a background on the definition and classification of LGMDs. The major effort focuses on progress in LGMD gene therapy, from experimental studies to clinical trials. The disorders discussed include the LGMDs where the most work has been done including calpainopathies (LGMD2A/R1), dysferlinopathies (LGMD2B/R2) and sarcoglycanopathies (LGMD2C/R5, LGMD2D/R3, LGMD2E/R4). Early success in clinical trials provides a template to move the field forward and potentially apply emerging technology like CRISPR/Cas9 that may enhance the scope and efficacy of gene therapy applied to patient care.

肢带性肌营养不良症(LGMDs)是一种主要的肌肉疾病。治疗是迫切需要的,目前正在扩大基于安全性和有效性,采用单剂量基因治疗的原则,治疗单基因常染色体隐性遗传病。基因治疗已经在LGMD方面取得了进展,本文综述了在这些疾病方面取得的进展。本文首先介绍了lgmd的定义和分类背景。主要工作集中在LGMD基因治疗的进展,从实验研究到临床试验。所讨论的疾病包括LGMDs,其中做了最多的工作,包括calpainopathies (LGMD2A/R1), dysferlinopathies (LGMD2B/R2)和sarcoglycanopathy (LGMD2C/R5, LGMD2D/R3, LGMD2E/R4)。临床试验的早期成功为推动该领域的发展提供了一个模板,并有可能应用CRISPR/Cas9等新兴技术,这些技术可能会扩大基因治疗应用于患者护理的范围和功效。
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引用次数: 21
Receiver operating characteristic plot and area under the curve with binary classifiers: pragmatic analysis of cognitive screening instruments. 二元分类器的受试者工作特征图和曲线下面积:认知筛选工具的语用分析。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-10-01 Epub Date: 2021-09-27 DOI: 10.2217/nmt-2021-0013
Gashirai K Mbizvo, Andrew J Larner

Aim: To examine whether receiver operating characteristic plots and area under the curve (AUC) values may be potentially misleading when assessing cognitive screening instruments as binary predictors rather than as categorical or continuous scales. Materials & methods: AUC was calculated using different methods (rank-sum, diagnostic odds ratio) using data from test accuracy studies of two binary classifiers of cognitive status (applause sign, attended with sign), a screener producing categorical data (Codex), and a continuous scale screening test (Mini-Addenbrooke's Cognitive Examination). Results: For all screeners, AUC calculated using diagnostic odds ratio method was greater than using rank-sum method. When Codex and Mini-Addenbrooke's Cognitive Examination were analyzed as binary (single fixed threshold) tests, AUC using rank-sum method was lower than when screeners were analyzed as categorical or continuous scales, respectively. Conclusion: If cognitive screeners producing categorical or continuous measures are dichotomized, calculated AUC may be an underestimate, thus affecting screening test accuracy.

目的:研究受试者工作特征图和曲线下面积(AUC)值是否可能在评估认知筛查工具作为二元预测因子而不是分类或连续量表时产生误导。材料和方法:AUC使用不同的方法(秩和、诊断优势比)计算,使用来自两个认知状态二元分类器(鼓掌标志、参加标志)、产生分类数据的筛选器(Codex)和连续量表筛选测试(Mini-Addenbrooke's cognitive Examination)的测试准确性研究数据。结果:对于所有筛查者,诊断优势比法计算的AUC均大于秩和法。当Codex和Mini-Addenbrooke认知检查作为二元(单一固定阈值)测试进行分析时,使用秩和方法的AUC分别低于筛选者作为分类或连续量表进行分析时的AUC。结论:如果对产生分类或连续测量的认知筛选者进行二分类,计算出的AUC可能会被低估,从而影响筛选测试的准确性。
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引用次数: 4
Inebilizumab for treatment of neuromyelitis optica spectrum disorder. 依比利珠单抗治疗视神经脊髓炎谱系障碍。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-10-01 Epub Date: 2021-09-06 DOI: 10.2217/nmt-2021-0017
Mark J Tullman, Aram Zabeti, Scott Vuocolo, Quinn Dinh
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease characterized by recurrent optic neuritis and transverse myelitis often resulting in severe disability. Anti-aquaporin-4-immunoglobulin (Ig) G is a pathogenic product of CD19-positive plasma cells found in most, but not all, individuals with NMOSD and is associated with immune-mediated neurologic injury. Inebilizumab, an afucosylated humanized IgG1 κ, anti-CD19 monoclonal antibody, may target pathogenic CD19-expressing B cells. In a Phase II/III trial, inebilizumab significantly reduced the proportion of participants experiencing an NMOSD attack and was well tolerated versus placebo. Fewer treated participants had worsening disability than those receiving placebo. Inebilizumab was approved in 2020 by the US FDA for treatment of anti-aquaporin-4 antibody positive NMOSD.
视神经脊髓炎视谱障碍(NMOSD)是一种罕见的自身免疫性疾病,以复发性视神经炎和横向脊髓炎为特征,常导致严重的残疾。抗aqp4免疫球蛋白G (IgG)是cd19阳性浆细胞的致病性产物,存在于大多数(但不是全部)NMOSD患者中,并与免疫介导的神经损伤有关。Inebilizumab是一种聚焦的人源IgG1κ抗cd19单克隆抗体,可靶向表达cd19的致病性B细胞。在一项II/III期试验中,与安慰剂相比,inebilizumab显著降低了NMOSD发作的参与者比例,并且耐受性良好。与接受安慰剂治疗的参与者相比,接受治疗的参与者残疾恶化的情况较少。Inebilizumab于2020年被美国FDA批准用于治疗抗aqp4抗体阳性的NMOSD。
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引用次数: 4
Musculoskeletal pain in Parkinson's disease: a narrative review. 帕金森病的肌肉骨骼疼痛:叙述性综述。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-10-01 Epub Date: 2021-08-19 DOI: 10.2217/nmt-2021-0011
Lauren Elizabeth Tueth, Ryan P Duncan

The prevalence of musculoskeletal (MSK) pain in people with Parkinson's disease (PD) is higher than that of age-matched controls. In this review, we outline what is known about MSK pain in PD, focusing on the neck, shoulder, knee, hip and low back. We also compare what is known about MSK pain in PD to what is known in older adults without PD. Finally, we outline areas of for future research related to MSK pain in people with PD.

帕金森病(PD)患者的肌肉骨骼(MSK)疼痛发生率高于年龄匹配的对照组。在本综述中,我们概述了有关帕金森病 MSK 疼痛的已知情况,重点关注颈部、肩部、膝部、髋部和腰部。我们还将对帕金森病患者的 MSK 疼痛的了解与未患帕金森病的老年人的了解进行了比较。最后,我们概述了与帕金森病患者 MSK 疼痛相关的未来研究领域。
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引用次数: 0
An updated review of teriflunomide's use in multiple sclerosis. 特立氟米特用于多发性硬化症的最新综述。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-10-01 Epub Date: 2021-09-16 DOI: 10.2217/nmt-2021-0014
Aaron E Miller

Teriflunomide, a once daily, oral disease-modifying therapy, has demonstrated consistent efficacy, safety and tolerability in patients with relapsing forms of multiple sclerosis (MS) and with a first clinical episode suggestive of MS treated up to 12 years. This review is an update to a previous version that examined data from the teriflunomide core clinical development program and extension studies. Data have since become available from active comparator trials with other disease-modifying therapies, treatment-related changes in brain volume (analyzed using structural image evaluation using normalization of atrophy) and real-world evidence including patient-reported outcomes. Initial data on the potential antiviral effects of teriflunomide in patients with MS, including case reports of patients infected with the 2019 novel coronavirus (SARS-CoV-2), are also presented.

泰瑞氟米特(Teriflunomide)是一种每日一次的口腔疾病改善疗法,对于复发型多发性硬化症(MS)患者和首次临床发作提示多发性硬化症的患者,治疗时间长达12年,已证明其疗效、安全性和耐受性一致。该综述是对先前版本的更新,该版本检查了特立氟米特核心临床开发计划和扩展研究的数据。此后,从其他疾病改善疗法的积极比较试验、治疗相关的脑容量变化(使用萎缩归一化的结构图像评估分析)和包括患者报告的结果在内的真实证据中获得了数据。还介绍了特立氟米特对多发性硬化症患者潜在抗病毒作用的初步数据,包括感染2019年新型冠状病毒(SARS-CoV-2)患者的病例报告。
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引用次数: 16
Potentially inappropriate prescriptions of antipsychotic and anticholinergic drugs in patients with Parkinson's disease. 帕金森病患者的抗精神病和抗胆碱能药物处方可能不适当。
IF 2.6 Q3 CLINICAL NEUROLOGY Pub Date : 2021-10-01 Epub Date: 2021-09-16 DOI: 10.2217/nmt-2021-0021
Luis Fernando Valladales-Restrepo, Nathalia Marcela Peña-Verjan, Katherine Vargas-Díaz, Jorge Enrique Machado-Alba

Aim: The objective was to determine the prevalence of the potentially inappropriate antipsychotics and anticholinergics used in patients with Parkinson's disease. Materials & methods: A cross-sectional study identified the prescription of antipsychotics, anticholinergics and drugs for the treatment of Parkinson's disease. The anticholinergic burden was evaluated, and quetiapine and clozapine were considered to be adequate antipsychotics. Results: 2965 patients with Parkinson's disease were identified. The presence of psychiatric disorders and other neurological pathologies was associated with a greater probability of receiving potentially inappropriate antipsychotic prescriptions. The presence of greater number of comorbidities was associated with a greater probability of receiving anticholinergics. Conclusion: Older age and associated comorbidities, especially psychiatric and neurological comorbidities, increase the likelihood of patients with Parkinson's disease being prescribed antipsychotics and anticholinergics.

目的:目的是确定帕金森病患者使用的潜在不适当的抗精神病药物和抗胆碱能药物的患病率。材料与方法:一项横断面研究确定了抗精神病药物、抗胆碱能药物和治疗帕金森病的药物的处方。评估了抗胆碱能负荷,喹硫平和氯氮平被认为是适当的抗精神病药物。结果:共发现2965例帕金森病患者。精神疾病和其他神经系统疾病的存在与接受潜在不适当的抗精神病药物处方的更大可能性相关。合并症的数量越多,接受抗胆碱能药物治疗的可能性越大。结论:老年和相关的合并症,特别是精神和神经系统合并症,增加了帕金森病患者服用抗精神病药物和抗胆碱能药物的可能性。
{"title":"Potentially inappropriate prescriptions of antipsychotic and anticholinergic drugs in patients with Parkinson's disease.","authors":"Luis Fernando Valladales-Restrepo,&nbsp;Nathalia Marcela Peña-Verjan,&nbsp;Katherine Vargas-Díaz,&nbsp;Jorge Enrique Machado-Alba","doi":"10.2217/nmt-2021-0021","DOIUrl":"https://doi.org/10.2217/nmt-2021-0021","url":null,"abstract":"<p><p><b>Aim:</b> The objective was to determine the prevalence of the potentially inappropriate antipsychotics and anticholinergics used in patients with Parkinson's disease. <b>Materials & methods:</b> A cross-sectional study identified the prescription of antipsychotics, anticholinergics and drugs for the treatment of Parkinson's disease. The anticholinergic burden was evaluated, and quetiapine and clozapine were considered to be adequate antipsychotics. <b>Results:</b> 2965 patients with Parkinson's disease were identified. The presence of psychiatric disorders and other neurological pathologies was associated with a greater probability of receiving potentially inappropriate antipsychotic prescriptions. The presence of greater number of comorbidities was associated with a greater probability of receiving anticholinergics. <b>Conclusion:</b> Older age and associated comorbidities, especially psychiatric and neurological comorbidities, increase the likelihood of patients with Parkinson's disease being prescribed antipsychotics and anticholinergics.</p>","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":"11 5","pages":"361-371"},"PeriodicalIF":2.6,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39418892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Neurodegenerative disease management
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