首页 > 最新文献

Neurobiology of Stress最新文献

英文 中文
Neuroanatomical prediction of individual anxiety problems level using machine learning models: A population-based cohort study of young adults 使用机器学习模型的个体焦虑问题水平的神经解剖学预测:一项基于人群的年轻人队列研究。
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2024.100705
Hui Xu , Jing Xu , Dandong Li
Anxiety, a mental state in healthy individuals, is characterized by apprehension of potential future threats. Though the neurobiological basis of anxiety has been investigated widely in the clinical populations, the underly mechanism of neuroanatomical correlates with anxiety level in healthy young adults is still unclear. In this study, 1080 young adults were enrolled from the Human Connectome Project Young Adult dataset, and machine learning-based elastic net regression models with cross validation, together with linear mix effects (LME) models were adopted to investigate whether the neuroanatomical profiles of structural magnetic resonance imaging indicators associated with anxiety level in healthy young adults. We found multi-region neuroanatomical profiles predicted anxiety problems level and it was still robust in an out-of-sample. The neuroanatomical profiles had widespread brain nodes, including the dorsal lateral prefrontal cortex, supramarginal gyrus, and entorhinal cortex, which implicated in the default mode network and frontoparietal network. This finding was further supported by LME models, which showed significant univariate associations between brain nodes with anxiety. In sum, it's a large sample size study with multivariate analysis methodology to provide evidence that individual anxiety problems level can be predicted by machine learning-based models in healthy young adults. The neuroanatomical signature including hub nodes involved theoretically relevant brain networks robustly predicts anxiety, which could aid the assessment of potential high-risk of anxiety individuals.
焦虑是健康人的一种精神状态,其特征是对未来潜在威胁的忧虑。尽管焦虑的神经生物学基础已经在临床人群中得到了广泛的研究,但健康年轻人焦虑水平与神经解剖学相关的潜在机制仍不清楚。在这项研究中,从人类连接组计划的年轻人数据集中招募了1080名年轻人,并采用基于交叉验证的机器学习弹性网络回归模型和线性混合效应(LME)模型来研究结构磁共振成像指标的神经解剖学特征是否与健康年轻人的焦虑水平相关。我们发现多区域神经解剖图谱预测焦虑问题水平,并且在样本外仍然是稳健的。神经解剖学特征显示广泛的脑淋巴结,包括背外侧前额叶皮层、边缘上回和内嗅皮层,这些淋巴结涉及默认模式网络和额顶叶网络。这一发现进一步得到了LME模型的支持,该模型显示脑节点与焦虑之间存在显著的单变量关联。总之,这是一项大样本研究,采用多变量分析方法,为健康年轻人的个体焦虑问题水平可以通过基于机器学习的模型预测提供证据。包括枢纽节点在内的神经解剖学特征涉及理论相关的脑网络,可以有效预测焦虑,有助于评估焦虑个体的潜在高危性。
{"title":"Neuroanatomical prediction of individual anxiety problems level using machine learning models: A population-based cohort study of young adults","authors":"Hui Xu ,&nbsp;Jing Xu ,&nbsp;Dandong Li","doi":"10.1016/j.ynstr.2024.100705","DOIUrl":"10.1016/j.ynstr.2024.100705","url":null,"abstract":"<div><div>Anxiety, a mental state in healthy individuals, is characterized by apprehension of potential future threats. Though the neurobiological basis of anxiety has been investigated widely in the clinical populations, the underly mechanism of neuroanatomical correlates with anxiety level in healthy young adults is still unclear. In this study, 1080 young adults were enrolled from the Human Connectome Project Young Adult dataset, and machine learning-based elastic net regression models with cross validation, together with linear mix effects (LME) models were adopted to investigate whether the neuroanatomical profiles of structural magnetic resonance imaging indicators associated with anxiety level in healthy young adults. We found multi-region neuroanatomical profiles predicted anxiety problems level and it was still robust in an out-of-sample. The neuroanatomical profiles had widespread brain nodes, including the dorsal lateral prefrontal cortex, supramarginal gyrus, and entorhinal cortex, which implicated in the default mode network and frontoparietal network. This finding was further supported by LME models, which showed significant univariate associations between brain nodes with anxiety. In sum, it's a large sample size study with multivariate analysis methodology to provide evidence that individual anxiety problems level can be predicted by machine learning-based models in healthy young adults. The neuroanatomical signature including hub nodes involved theoretically relevant brain networks robustly predicts anxiety, which could aid the assessment of potential high-risk of anxiety individuals.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"34 ","pages":"Article 100705"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain receptor dynamics in early and adult life stress: Gateways to maladaptive coping strategies
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2025.100707
Sora Shin
Stress plays a significant role in the onset of numerous psychiatric disorders. Depending on individual resilience or stressor's nature, long-term changes to stress in the brain can lead to a wide range of behavioral symptoms, including social withdrawal, feelings of helplessness, and emotional overeating. The brain receptor molecules are key mediators of these processes, translating neuromodulatory signals into neuronal responses or circuit activity changes that ultimately shape behavioral outcomes. Here, I highlight several of my previous studies that reveal the pivotal role of receptor molecules in critical brain regions such as the nucleus accumbens, lateral hypothalamus, and lateral septum. I identified how mGluR5 signaling in the nucleus accumbens promotes stress resilience through pathways involving ΔFosB and SRF, while leptin receptor or glucocorticoid receptor signaling within lateral hypothalamic circuits contributes to stress eating. Additionally, I uncovered the role of dopamine receptor 3 signaling in the lateral septum in mediating the impact of early life stress on social behaviors. These findings underscore the functional relevance of brain receptor molecules in transducing stress—from early life through adulthood—into maladaptive coping behaviors. As druggable targets, these receptor-mediated pathways provide a critical foundation for developing targeted interventions to alleviate stress-related psychiatric symptoms.
{"title":"Brain receptor dynamics in early and adult life stress: Gateways to maladaptive coping strategies","authors":"Sora Shin","doi":"10.1016/j.ynstr.2025.100707","DOIUrl":"10.1016/j.ynstr.2025.100707","url":null,"abstract":"<div><div>Stress plays a significant role in the onset of numerous psychiatric disorders. Depending on individual resilience or stressor's nature, long-term changes to stress in the brain can lead to a wide range of behavioral symptoms, including social withdrawal, feelings of helplessness, and emotional overeating. The brain receptor molecules are key mediators of these processes, translating neuromodulatory signals into neuronal responses or circuit activity changes that ultimately shape behavioral outcomes. Here, I highlight several of my previous studies that reveal the pivotal role of receptor molecules in critical brain regions such as the nucleus accumbens, lateral hypothalamus, and lateral septum. I identified how mGluR5 signaling in the nucleus accumbens promotes stress resilience through pathways involving ΔFosB and SRF, while leptin receptor or glucocorticoid receptor signaling within lateral hypothalamic circuits contributes to stress eating. Additionally, I uncovered the role of dopamine receptor 3 signaling in the lateral septum in mediating the impact of early life stress on social behaviors. These findings underscore the functional relevance of brain receptor molecules in transducing stress—from early life through adulthood—into maladaptive coping behaviors. As druggable targets, these receptor-mediated pathways provide a critical foundation for developing targeted interventions to alleviate stress-related psychiatric symptoms.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"34 ","pages":"Article 100707"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats 升高的gaba能神经传递可防止慢性间歇乙醇诱导的雌性大鼠腹侧下背内外输入的高兴奋性。
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2025-01-01 DOI: 10.1016/j.ynstr.2024.100696
Eva C. Bach, Jeff L. Weiner
With the recent rise in the rate of alcohol use disorder (AUD) in women, the historical gap between men and women living with this condition is narrowing. While there are many commonalities in how men and women are impacted by AUD, an accumulating body of evidence is revealing sex-dependent adaptations that may require distinct therapeutic approaches. Preclinical rodent studies are beginning to shed light on sex differences in the effects of chronic alcohol exposure on synaptic activity in a number of brain regions. Prior studies from our laboratory revealed that, while withdrawal from chronic intermittent ethanol (CIE), a commonly used model of AUD, increased excitability in the ventral hippocampus (vHC) of male rats, this same treatment had the opposite effect in females. A follow-up study not only expanded on the synaptic mechanisms of these findings in male rats, but also established a CIE-dependent increase in the excitatory-inhibitory (E-I) balance of a glutamatergic projection from the basolateral amygdala to vHC (BLA-vHC). This pathway modulates anxiety-like behavior and could help explain the comorbid occurrence of anxiety disorders in individuals suffering from AUD. The present study sought to conduct a similar analysis of CIE effects on both synaptic mechanisms in the vHC and adaptations in the BLA-vHC pathway of female rats. Our findings indicate that CIE increases the strength of inhibitory neurotransmission in the vHC and that this sex-specific adaptation blocks, or at least delays, the increases in intrinsic vHC excitability and BLA-vHC synaptic transmission observed in males. Our findings establish the BLA-vHC pathway and the vHC as important circuitry to consider for future studies directed at identifying sex-dependent therapeutic approaches to AUD.
随着最近女性酒精使用障碍(AUD)率的上升,患有这种疾病的男性和女性之间的历史差距正在缩小。虽然男性和女性受到AUD影响的方式有许多共同点,但越来越多的证据表明,性别依赖的适应可能需要不同的治疗方法。临床前啮齿类动物研究开始揭示慢性酒精暴露对大脑许多区域突触活动影响的性别差异。我们实验室之前的研究表明,虽然从慢性间歇性乙醇(CIE)中退出(一种常用的AUD模型)会增加雄性大鼠腹侧海马(vHC)的兴奋性,但同样的治疗在雌性大鼠中却有相反的效果。一项后续研究不仅在雄性大鼠中扩展了这些发现的突触机制,而且还建立了从基底外侧杏仁核到vHC (BLA-vHC)的谷氨酸能投射的兴奋-抑制(E-I)平衡依赖于cie的增加。这一通路调节焦虑样行为,有助于解释AUD患者焦虑障碍的共病发生。本研究试图对CIE对雌性大鼠vHC突触机制和BLA-vHC通路适应性的影响进行类似的分析。我们的研究结果表明,CIE增加了vHC中抑制性神经传递的强度,这种性别特异性适应阻断或至少延迟了在男性中观察到的vHC内在兴奋性和BLA-vHC突触传递的增加。我们的研究结果确定了BLA-vHC通路和vHC是未来研究中重要的回路,这些研究旨在确定AUD的性别依赖性治疗方法。
{"title":"Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats","authors":"Eva C. Bach,&nbsp;Jeff L. Weiner","doi":"10.1016/j.ynstr.2024.100696","DOIUrl":"10.1016/j.ynstr.2024.100696","url":null,"abstract":"<div><div>With the recent rise in the rate of alcohol use disorder (AUD) in women, the historical gap between men and women living with this condition is narrowing. While there are many commonalities in how men and women are impacted by AUD, an accumulating body of evidence is revealing sex-dependent adaptations that may require distinct therapeutic approaches. Preclinical rodent studies are beginning to shed light on sex differences in the effects of chronic alcohol exposure on synaptic activity in a number of brain regions. Prior studies from our laboratory revealed that, while withdrawal from chronic intermittent ethanol (CIE), a commonly used model of AUD, increased excitability in the ventral hippocampus (vHC) of male rats, this same treatment had the opposite effect in females. A follow-up study not only expanded on the synaptic mechanisms of these findings in male rats, but also established a CIE-dependent increase in the excitatory-inhibitory (E-I) balance of a glutamatergic projection from the basolateral amygdala to vHC (BLA-vHC). This pathway modulates anxiety-like behavior and could help explain the comorbid occurrence of anxiety disorders in individuals suffering from AUD. The present study sought to conduct a similar analysis of CIE effects on both synaptic mechanisms in the vHC and adaptations in the BLA-vHC pathway of female rats. Our findings indicate that CIE increases the strength of inhibitory neurotransmission in the vHC and that this sex-specific adaptation blocks, or at least delays, the increases in intrinsic vHC excitability and BLA-vHC synaptic transmission observed in males. Our findings establish the BLA-vHC pathway and the vHC as important circuitry to consider for future studies directed at identifying sex-dependent therapeutic approaches to AUD.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"34 ","pages":"Article 100696"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11722943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptome dynamics in mouse amygdala under acute and chronic stress revealed by thiol-labeled RNA sequencing 硫醇标记的 RNA 测序揭示急性和慢性应激下小鼠杏仁核转录组的动态变化
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100688
Dan Zhao , Lu Zhang , Yang Yang
Both acute and chronic stress have significant impact on brain functions. The amygdala is essential in mediating stress responses, but how its transcriptomic dynamics change under stress remains elusive. To overcome the difficulties in detecting subtle stress-induced changes by evaluating total RNA using classic RNA sequencing, we conducted thiol-labeled RNA sequencing (SLAM-seq). We injected 4-thiouridine (4sU) into mouse amygdala followed by SLAM-seq to detect nascent mRNA induced by acute and chronic restraint stress, and found that SLAM-seq could label actively transcribed genes in the major neuronal and glial subtypes. Using SLAM-seq, we found that chronic stress led to higher turnover of a group of genes associated with myelination, and this finding is confirmed by immunostaining which showed increased myelination in the chronically stressed amygdala. Additionally, genes detected by SLAM-seq and RNA-seq only partially overlapped, suggesting that SLAM-seq and RNA-seq are complementary in identifying stress-responsive genes. By applying SLAM-seq in vivo, we obtained a rich dataset of genes with higher turnover in the amygdala under stress.
急性和慢性压力都会对大脑功能产生重大影响。杏仁核是介导应激反应的重要器官,但其转录组动态如何在应激下发生变化仍是一个未知数。为了克服用传统的RNA测序方法评估总RNA来检测应激诱导的微妙变化的困难,我们进行了硫醇标记RNA测序(SLAM-seq)。我们向小鼠杏仁核注射了4-硫代硫甙(4sU),然后用SLAM-seq检测急性和慢性束缚应激诱导的新生mRNA,结果发现SLAM-seq可以标记主要神经元和神经胶质亚型中的活跃转录基因。通过使用 SLAM-seq,我们发现慢性应激导致一组与髓鞘化相关的基因更替率升高,这一发现得到了免疫染色的证实,免疫染色显示慢性应激杏仁核中的髓鞘化增加。此外,SLAM-seq和RNA-seq检测到的基因只有部分重叠,这表明SLAM-seq和RNA-seq在鉴定应激反应基因方面是互补的。通过在体内应用 SLAM-seq,我们获得了在应激状态下杏仁核中周转率较高的基因的丰富数据集。
{"title":"Transcriptome dynamics in mouse amygdala under acute and chronic stress revealed by thiol-labeled RNA sequencing","authors":"Dan Zhao ,&nbsp;Lu Zhang ,&nbsp;Yang Yang","doi":"10.1016/j.ynstr.2024.100688","DOIUrl":"10.1016/j.ynstr.2024.100688","url":null,"abstract":"<div><div>Both acute and chronic stress have significant impact on brain functions. The amygdala is essential in mediating stress responses, but how its transcriptomic dynamics change under stress remains elusive. To overcome the difficulties in detecting subtle stress-induced changes by evaluating total RNA using classic RNA sequencing, we conducted thiol-labeled RNA sequencing (SLAM-seq). We injected 4-thiouridine (4sU) into mouse amygdala followed by SLAM-seq to detect nascent mRNA induced by acute and chronic restraint stress, and found that SLAM-seq could label actively transcribed genes in the major neuronal and glial subtypes. Using SLAM-seq, we found that chronic stress led to higher turnover of a group of genes associated with myelination, and this finding is confirmed by immunostaining which showed increased myelination in the chronically stressed amygdala. Additionally, genes detected by SLAM-seq and RNA-seq only partially overlapped, suggesting that SLAM-seq and RNA-seq are complementary in identifying stress-responsive genes. By applying SLAM-seq <em>in vivo</em>, we obtained a rich dataset of genes with higher turnover in the amygdala under stress.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100688"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols 小鼠对慢性失败压力的行为应对:当前方案的系统回顾
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100689
Alina Díez-Solinska , Zurine De Miguel , Garikoitz Azkona , Oscar Vegas
Social stress is the most significant source of chronic stress in humans and is commonly associated with health impairment. Individual differences in the behavioral coping responses to stress have been proposed to mediate the negative effects of stress on physical, behavioral and mental health. Animal models, particularly mice, offer valuable insights into the physiological and neurobiological correlates of behavioral coping strategies in response to chronic social stress. Here we aim to identify differences and similarities among stress protocols in mice, with particular attention to how neuroendocrine and/or behavioral responses vary according to different coping strategies, while highlighting the need for standardized approaches in future research. A systematic review was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA statement). A total of 213 references were identified by electronic search, and after the screening, 18 articles were found to meet all the established criteria. We analyzed differences in the stress protocol, the characterization and classification of coping strategies and the physiological and behavioral differences according to coping. The results show that differences in behavioural expression under chronic social stress (coping) may also be associated with physiological differences and differential susceptibility to disease. However, this review also underlines the importance of a cautious interpretation of the results obtained. The lack of consistency in the nomenclature and procedures associated with the study of coping strategies for social stress, as well as the absence of a uniform classification, highlight the importance of using a common language when approaching the study of coping strategies. Thereby, this review encourages the development of a more defined method and criteria for assessing coping strategies, based on both behavioral and biological indicators.
社会压力是人类最主要的慢性压力来源,通常与健康受损有关。有人提出,个体在应对压力的行为反应方面存在差异,这可能是压力对身体、行为和心理健康产生负面影响的中介因素。动物模型,尤其是小鼠,为我们深入了解应对慢性社会压力的行为策略的生理和神经生物学相关性提供了宝贵的资料。在此,我们旨在找出小鼠应激方案之间的异同,特别关注神经内分泌和/或行为反应如何根据不同的应对策略而变化,同时强调在未来研究中采用标准化方法的必要性。我们按照《系统综述和元分析首选报告项目》(PRISMA 声明)进行了系统综述。通过电子检索共找到 213 篇参考文献,经过筛选,发现 18 篇文章符合所有既定标准。我们分析了压力协议的差异、应对策略的特征和分类以及应对策略的生理和行为差异。结果表明,慢性社会压力(应对)下的行为表现差异也可能与生理差异和对疾病的不同易感性有关。不过,本综述也强调了谨慎解释所获结果的重要性。与社会压力应对策略研究相关的术语和程序缺乏一致性,也没有统一的分类方法,这突出了在研究应对策略时使用共同语言的重要性。因此,本综述鼓励根据行为和生物指标,制定更加明确的应对策略评估方法和标准。
{"title":"Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols","authors":"Alina Díez-Solinska ,&nbsp;Zurine De Miguel ,&nbsp;Garikoitz Azkona ,&nbsp;Oscar Vegas","doi":"10.1016/j.ynstr.2024.100689","DOIUrl":"10.1016/j.ynstr.2024.100689","url":null,"abstract":"<div><div>Social stress is the most significant source of chronic stress in humans and is commonly associated with health impairment. Individual differences in the behavioral coping responses to stress have been proposed to mediate the negative effects of stress on physical, behavioral and mental health. Animal models, particularly mice, offer valuable insights into the physiological and neurobiological correlates of behavioral coping strategies in response to chronic social stress. Here we aim to identify differences and similarities among stress protocols in mice, with particular attention to how neuroendocrine and/or behavioral responses vary according to different coping strategies, while highlighting the need for standardized approaches in future research. A systematic review was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA statement). A total of 213 references were identified by electronic search, and after the screening, 18 articles were found to meet all the established criteria. We analyzed differences in the stress protocol, the characterization and classification of coping strategies and the physiological and behavioral differences according to coping. The results show that differences in behavioural expression under chronic social stress (coping) may also be associated with physiological differences and differential susceptibility to disease. However, this review also underlines the importance of a cautious interpretation of the results obtained. The lack of consistency in the nomenclature and procedures associated with the study of coping strategies for social stress, as well as the absence of a uniform classification, highlight the importance of using a common language when approaching the study of coping strategies. Thereby, this review encourages the development of a more defined method and criteria for assessing coping strategies, based on both behavioral and biological indicators.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100689"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Withdrawal notice to: “Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats” [Neurobiol. Stress 32 (2024) 100665] 撤回通知:“升高的gaba能神经传递可防止慢性间歇乙醇诱导的雌性大鼠腹侧下背内在和外在输入的高兴奋性”[神经生物学]。压力32 (2024)100665]
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100693
Eva C. Bach, Jeff L. Weiner
{"title":"Withdrawal notice to: “Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats” [Neurobiol. Stress 32 (2024) 100665]","authors":"Eva C. Bach,&nbsp;Jeff L. Weiner","doi":"10.1016/j.ynstr.2024.100693","DOIUrl":"10.1016/j.ynstr.2024.100693","url":null,"abstract":"","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100693"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets 神经元周围网络对压力、疼痛和酒精相关行为的调节作用
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100692
Jhoan S. Aguilar , Amy W. Lasek
Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity. Most PNNs in the brain surround parvalbumin-expressing inhibitory interneurons, which tightly regulate excitatory/inhibitory balance and brain activity associated with optimal cognitive functioning. Alterations in PNNs have been observed in neurological diseases and psychiatric disorders, suggesting that they may be key contributors to the neuropathological progression and behavioral changes in these diseases. Alcohol use disorder (AUD), major depressive disorder (MDD), and chronic pain are highly comorbid conditions, and changes in PNNs have been observed in animal models of these disorders, as well as postmortem tissue from individuals diagnosed with AUD and MDD. This review focuses on the literature describing stress-, alcohol-, and pain-induced adaptations in PNNs, potential cellular contributors to altered PNNs, and the role of PNNs in behaviors related to these disorders. Medicines that can restore PNNs to a non-pathological state may be a novel therapeutic approach to treating chronic pain, AUD, and MDD.
神经元周围网(PNN)是中枢神经系统细胞外基质的一种特殊形式,富含透明质酸、硫酸软骨素蛋白多糖、腱鞘蛋白和调节突触可塑性的连接蛋白。大脑中的大多数 PNN 都围绕着表达抑制性中间神经元的副发光体,而抑制性中间神经元则密切调节兴奋/抑制平衡以及与最佳认知功能相关的大脑活动。在神经系统疾病和精神疾病中已观察到 PNN 的变化,这表明它们可能是导致这些疾病的神经病理学进展和行为变化的关键因素。酒精使用障碍(AUD)、重度抑郁障碍(MDD)和慢性疼痛是高度并发症,在这些疾病的动物模型以及被诊断为酒精使用障碍和重度抑郁障碍患者的死后组织中都观察到了 PNNs 的变化。本综述将重点关注描述压力、酒精和疼痛引起的 PNNs 适应性的文献、导致 PNNs 改变的潜在细胞因素,以及 PNNs 在与这些疾病相关的行为中的作用。能将 PNNs 恢复到非病理状态的药物可能是治疗慢性疼痛、AUD 和 MDD 的一种新型治疗方法。
{"title":"Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets","authors":"Jhoan S. Aguilar ,&nbsp;Amy W. Lasek","doi":"10.1016/j.ynstr.2024.100692","DOIUrl":"10.1016/j.ynstr.2024.100692","url":null,"abstract":"<div><div>Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity. Most PNNs in the brain surround parvalbumin-expressing inhibitory interneurons, which tightly regulate excitatory/inhibitory balance and brain activity associated with optimal cognitive functioning. Alterations in PNNs have been observed in neurological diseases and psychiatric disorders, suggesting that they may be key contributors to the neuropathological progression and behavioral changes in these diseases. Alcohol use disorder (AUD), major depressive disorder (MDD), and chronic pain are highly comorbid conditions, and changes in PNNs have been observed in animal models of these disorders, as well as postmortem tissue from individuals diagnosed with AUD and MDD. This review focuses on the literature describing stress-, alcohol-, and pain-induced adaptations in PNNs, potential cellular contributors to altered PNNs, and the role of PNNs in behaviors related to these disorders. Medicines that can restore PNNs to a non-pathological state may be a novel therapeutic approach to treating chronic pain, AUD, and MDD.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100692"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute stress activates basolateral amygdala neurons expressing corticotropin-releasing hormone receptor type 1 (CRHR1): Topographical distribution and projection-specific activation in male and female rats 急性应激可激活表达促肾上腺皮质激素释放激素受体 1 型 (CRHR1) 的杏仁核基底外侧神经元:雌雄大鼠的地形分布和投射特异性激活
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100694
Robert J. Aukema , Gavin N. Petrie , Samantha L. Baglot , Nicholas W. Gilpin , Matthew N. Hill
Although the basolateral amygdala (BLA) and corticotropin releasing hormone receptor type I (CRHR1) signaling are both central to the stress response, the spatial and circuit-specific distribution of CRHR1 have not been identified in the BLA at a high resolution. We used transgenic male and female CRHR1-Cre-tdTomato rats to topographically map the distribution of BLACRHR1 neurons and identify whether they are activated by acute stress. Additionally, we used the BLA circuits projecting to the central amygdala (CeA) and nucleus accumbens (NAc) as a model to test circuit-specific expression of CRHR1 in the BLA. We established several key findings. First, CRHR1 had the strongest expression in the lateral amygdala and in caudal portions of the BLA. Second, acute restraint stress increased FOS expression of CRHR1 neurons, and stress-induced activation was particularly strong in medial subregions of the BLA. Third, stress significantly increased FOS expression on BLA-NAc, but not BLA-CeA projectors, and BLA-NAc activation was more robust in males than females. Finally, CRHR1 was expressed on a subset of BLA-CeA and BLA-NAc projection neurons. Collectively, this expands our understanding of BLA molecular- and circuit-specific activation patterns following acute stress.
尽管杏仁基底外侧(BLA)和促肾上腺皮质激素释放激素受体 I 型(CRHR1)信号传导都是应激反应的核心,但 CRHR1 在杏仁基底外侧的空间和回路特异性分布尚未得到高分辨率的鉴定。我们利用转基因雄性和雌性 CRHR1-Cre-tdTomato 大鼠绘制了 BLACRHR1 神经元分布的地形图,并确定它们是否被急性应激激活。此外,我们还以投射到杏仁核中枢(CeA)和伏隔核(NAc)的BLA回路为模型,测试了CRHR1在BLA回路中的特异性表达。我们得出了几个重要发现。首先,CRHR1在杏仁核外侧和BLA尾部的表达最强。第二,急性束缚应激增加了CRHR1神经元的FOS表达,应激诱导的激活在BLA的内侧亚区尤其强烈。第三,应激明显增加了BLA-NAc上的FOS表达,但没有增加BLA-CeA突起上的FOS表达,而且男性的BLA-NAc激活比女性更强。最后,CRHR1在一部分BLA-CeA和BLA-NAc投射神经元上表达。总之,这拓展了我们对急性应激后BLA分子和回路特异性激活模式的理解。
{"title":"Acute stress activates basolateral amygdala neurons expressing corticotropin-releasing hormone receptor type 1 (CRHR1): Topographical distribution and projection-specific activation in male and female rats","authors":"Robert J. Aukema ,&nbsp;Gavin N. Petrie ,&nbsp;Samantha L. Baglot ,&nbsp;Nicholas W. Gilpin ,&nbsp;Matthew N. Hill","doi":"10.1016/j.ynstr.2024.100694","DOIUrl":"10.1016/j.ynstr.2024.100694","url":null,"abstract":"<div><div>Although the basolateral amygdala (BLA) and corticotropin releasing hormone receptor type I (CRHR1) signaling are both central to the stress response, the spatial and circuit-specific distribution of CRHR1 have not been identified in the BLA at a high resolution. We used transgenic male and female CRHR1-Cre-tdTomato rats to topographically map the distribution of BLA<sup>CRHR1</sup> neurons and identify whether they are activated by acute stress. Additionally, we used the BLA circuits projecting to the central amygdala (CeA) and nucleus accumbens (NAc) as a model to test circuit-specific expression of CRHR1 in the BLA. We established several key findings. First, CRHR1 had the strongest expression in the lateral amygdala and in caudal portions of the BLA. Second, acute restraint stress increased FOS expression of CRHR1 neurons, and stress-induced activation was particularly strong in medial subregions of the BLA. Third, stress significantly increased FOS expression on BLA-NAc, but not BLA-CeA projectors, and BLA-NAc activation was more robust in males than females. Finally, CRHR1 was expressed on a subset of BLA-CeA and BLA-NAc projection neurons. Collectively, this expands our understanding of BLA molecular- and circuit-specific activation patterns following acute stress.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100694"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress 早期生活压力诱发的肠道-大脑表型的恢复力和合并症的性别特异性肠道微生物群特征
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100686
Lars Wilmes , Valentina Caputi , Thomaz F.S. Bastiaanssen , James M. Collins , Fiona Crispie , Paul D. Cotter , Timothy G. Dinan , John F. Cryan , Gerard Clarke , Siobhain M. O'Mahony

Background

Alterations in gut-brain axis communication pathways and the gut microbiota ecosystem caused by early life stress have been extensively described as critical players in the pathophysiology of stress-induced disorders. However, the extent to which stress-induced gut microbiota alterations manifest in early life and contribute to the sex-specific susceptibility to distinct gut-brain phenotypes in adulthood has yet to be defined.

Methods

Male and female Sprague-Dawley rat offspring underwent maternal separation (3h/day from postnatal day 2–12). Faecal samples were collected before weaning for gut microbiota 16S rRNA sequencing and metabolomic analysis. Visceral pain sensitivity and negative valence behaviours were assessed in adulthood using colorectal distension and the forced swim test respectively. Behavioural data were processed in a two-step cluster analysis to identify groupings within the dataset. Multi-omics analysis was carried out to investigate if the microbial signatures following early life stress were already defined according to the membership of the adult behavioural phenotypes.

Results

Maternal separation resulted in increased visceral hypersensitivity while showing a trend for a sex-dependent increase in negative valence behaviour in adulthood. The cluster analysis revealed four clusters within the dataset representing distinct pathophysiological domains reminiscent of the behavioural consequences of early-life stress: 1. resilient, 2. pain, 3. immobile and 4. comorbid. The early life gut microbiota of each of these clusters show distinct alterations in terms of diversity, genus level differential abundance, and functional modules. Multi-omic integrations points towards a role for different metabolic pathways underlying each cluster-specific phenotype.

Conclusion

Our study is the first to identify distinct phenotypes defined by susceptibility or resilience to gut-brain dysfunction induced by early life stress. The gut microbiota in early life shows sex-dependent alterations in each cluster that precede specific behavioural phenotypes in adulthood. Future research is warranted to determine the causal relationship between early-life stress-induced changes in the gut microbiota and to understand the trajectory leading to the manifestation of different behavioural phenotypes in adulthood.
背景早期生活压力引起的肠道-大脑轴沟通途径和肠道微生物群生态系统的改变已被广泛描述为压力诱发疾病的病理生理学中的关键因素。然而,应激诱导的肠道微生物群改变在生命早期的表现程度,以及在成年期对不同肠道-大脑表型的性别特异性易感性的贡献程度尚未确定。方法对雌雄Sprague-Dawley大鼠后代进行母鼠分离(从出生后第2-12天,每天3小时)。断奶前收集粪便样本,进行肠道微生物群 16S rRNA 测序和代谢组学分析。成年后,分别使用结肠直肠胀气和强迫游泳测试评估内脏痛敏感性和负价行为。对行为数据进行了两步聚类分析,以确定数据集中的分组情况。结果 母体分离导致内脏超敏性增加,同时成年后负价行为的增加趋势与性别有关。聚类分析揭示了数据集中的四个聚类,它们代表了不同的病理生理领域,让人联想到早期生活压力的行为后果:1.适应力强;2.疼痛;3.行动不便;4.合并症。这些群组中每个群组的生命早期肠道微生物群在多样性、属级丰度差异和功能模块方面都显示出不同的变化。我们的研究首次发现了不同的表型,这些表型由生命早期压力诱发的肠道-大脑功能障碍的易感性或恢复力所定义。生命早期的肠道微生物群在每个群中都显示出性别依赖性改变,这些改变先于成年期的特定行为表型。未来的研究需要确定早期生活压力诱导的肠道微生物群变化之间的因果关系,并了解导致成年后表现出不同行为表型的轨迹。
{"title":"Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress","authors":"Lars Wilmes ,&nbsp;Valentina Caputi ,&nbsp;Thomaz F.S. Bastiaanssen ,&nbsp;James M. Collins ,&nbsp;Fiona Crispie ,&nbsp;Paul D. Cotter ,&nbsp;Timothy G. Dinan ,&nbsp;John F. Cryan ,&nbsp;Gerard Clarke ,&nbsp;Siobhain M. O'Mahony","doi":"10.1016/j.ynstr.2024.100686","DOIUrl":"10.1016/j.ynstr.2024.100686","url":null,"abstract":"<div><h3>Background</h3><div>Alterations in gut-brain axis communication pathways and the gut microbiota ecosystem caused by early life stress have been extensively described as critical players in the pathophysiology of stress-induced disorders. However, the extent to which stress-induced gut microbiota alterations manifest in early life and contribute to the sex-specific susceptibility to distinct gut-brain phenotypes in adulthood has yet to be defined.</div></div><div><h3>Methods</h3><div>Male and female Sprague-Dawley rat offspring underwent maternal separation (3h/day from postnatal day 2–12). Faecal samples were collected before weaning for gut microbiota 16S rRNA sequencing and metabolomic analysis. Visceral pain sensitivity and negative valence behaviours were assessed in adulthood using colorectal distension and the forced swim test respectively. Behavioural data were processed in a two-step cluster analysis to identify groupings within the dataset. Multi-omics analysis was carried out to investigate if the microbial signatures following early life stress were already defined according to the membership of the adult behavioural phenotypes.</div></div><div><h3>Results</h3><div>Maternal separation resulted in increased visceral hypersensitivity while showing a trend for a sex-dependent increase in negative valence behaviour in adulthood. The cluster analysis revealed four clusters within the dataset representing distinct pathophysiological domains reminiscent of the behavioural consequences of early-life stress: 1. resilient, 2. pain, 3. immobile and 4. comorbid. The early life gut microbiota of each of these clusters show distinct alterations in terms of diversity, genus level differential abundance, and functional modules. Multi-omic integrations points towards a role for different metabolic pathways underlying each cluster-specific phenotype.</div></div><div><h3>Conclusion</h3><div>Our study is the first to identify distinct phenotypes defined by susceptibility or resilience to gut-brain dysfunction induced by early life stress. The gut microbiota in early life shows sex-dependent alterations in each cluster that precede specific behavioural phenotypes in adulthood. Future research is warranted to determine the causal relationship between early-life stress-induced changes in the gut microbiota and to understand the trajectory leading to the manifestation of different behavioural phenotypes in adulthood.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100686"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transient impact of chronic social stress on effort-based reward motivation in non-food restricted mice: Involvement of corticosterone 慢性社会应激对非食物限制小鼠基于努力的奖赏动机的短暂影响皮质酮的参与
IF 4.3 2区 医学 Q1 NEUROSCIENCES Pub Date : 2024-11-01 DOI: 10.1016/j.ynstr.2024.100690
Danina Evertse , Pilar Alves-Martinez , Giulia Treccani , Marianne B. Müller , Frank J. Meye , Michael A. van der Kooij
Chronic stress has been connected to a reduced effort and motivational deficits. To study effort-based motivation in rodents, operant conditioning is often employed. However, caloric restriction is typically imposed simultaneously. Since caloric restriction is a stressor in its own right, this procedure interferes with data interpretation. Here, we investigate whether chronic social defeat stress (CSD), lasting 10 consecutive days, would alter effort-based reward motivation in mice trained under ad libitum food conditions. Utilizing operant FED3 boxes in home cages, mice were trained within eight days to nose poke for palatable food. After training completion, operant memory was retained for at least 16 days, and mice demonstrated sustained effort, as assessed with a progressive ratio schedule, to obtain reward pellets. Directly after CSD exposure (10th day), mice exhibited reduced effort for palatable food rewards, but also displayed reduced nose poking in general. The effects of CSD on effort were short-lived, with no lasting impact on effort-based reward motivation one week post-stress. As corticosterone (CORT) levels were increased at day 10 of CSD, but not at day 17, we hypothesized that CORT might mediate the acute effects of CSD on effort-based reward motivation. Indeed, CORT administration [100 μg/ml], supplied via the drinking water, mirrored the CSD-induced CORT spike and temporarily reduced reward motivation. Our findings emphasize that CSD does not result in long-term deficits in reward motivation, suggesting a resilient adaptive response in mice under unrestricted feeding conditions. This study underscores the necessity of considering temporal dynamics of stress impacts and highlights the modulating effects of CORT. These insights contribute to a deeper understanding of the resilience mechanisms in motivational impairments and pave the way for further research into factors facilitating this resilience.
慢性压力与努力减少和动机缺陷有关。为了研究啮齿类动物基于努力的动机,通常会采用操作性条件反射。不过,通常会同时实施热量限制。由于热量限制本身就是一种压力源,因此这种程序会干扰数据解释。在此,我们研究了连续10天的慢性社会挫败应激(CSD)是否会改变在自由食物条件下接受训练的小鼠基于努力的奖赏动机。利用家用笼子中的操作性 FED3 盒,在八天内训练小鼠用鼻子捅可口的食物。训练完成后,操作性记忆至少保留了 16 天,而且小鼠表现出了持续的努力(通过累进比率计划进行评估),以获得奖励颗粒。直接暴露于 CSD 后(第 10 天),小鼠在获得适口食物奖励时表现出的努力程度降低,但戳鼻子的行为也普遍减少。CSD对努力程度的影响是短暂的,在应激一周后对基于努力程度的奖励动机没有持续影响。由于皮质酮(CORT)水平在CSD第10天升高,但在第17天没有升高,我们假设CORT可能会介导CSD对努力奖赏动机的急性影响。事实上,通过饮用水提供的 CORT [100 μg/ml] 反映了 CSD 诱导的 CORT 激增,并暂时降低了奖赏动机。我们的研究结果强调,CSD 不会导致奖赏动机的长期缺陷,这表明小鼠在无限制喂养条件下的适应性反应具有弹性。这项研究强调了考虑压力影响的时间动态的必要性,并突出了CORT的调节作用。这些见解有助于更深入地了解动机损伤的恢复机制,并为进一步研究促进这种恢复的因素铺平了道路。
{"title":"Transient impact of chronic social stress on effort-based reward motivation in non-food restricted mice: Involvement of corticosterone","authors":"Danina Evertse ,&nbsp;Pilar Alves-Martinez ,&nbsp;Giulia Treccani ,&nbsp;Marianne B. Müller ,&nbsp;Frank J. Meye ,&nbsp;Michael A. van der Kooij","doi":"10.1016/j.ynstr.2024.100690","DOIUrl":"10.1016/j.ynstr.2024.100690","url":null,"abstract":"<div><div>Chronic stress has been connected to a reduced effort and motivational deficits. To study effort-based motivation in rodents, operant conditioning is often employed. However, caloric restriction is typically imposed simultaneously. Since caloric restriction is a stressor in its own right, this procedure interferes with data interpretation. Here, we investigate whether chronic social defeat stress (CSD), lasting 10 consecutive days, would alter effort-based reward motivation in mice trained under <em>ad libitum</em> food conditions. Utilizing operant FED3 boxes in home cages, mice were trained within eight days to nose poke for palatable food. After training completion, operant memory was retained for at least 16 days, and mice demonstrated sustained effort, as assessed with a progressive ratio schedule, to obtain reward pellets. Directly after CSD exposure (10th day), mice exhibited reduced effort for palatable food rewards, but also displayed reduced nose poking in general. The effects of CSD on effort were short-lived, with no lasting impact on effort-based reward motivation one week post-stress. As corticosterone (CORT) levels were increased at day 10 of CSD, but not at day 17, we hypothesized that CORT might mediate the acute effects of CSD on effort-based reward motivation. Indeed, CORT administration [100 μg/ml], supplied via the drinking water, mirrored the CSD-induced CORT spike and temporarily reduced reward motivation. Our findings emphasize that CSD does not result in long-term deficits in reward motivation, suggesting a resilient adaptive response in mice under unrestricted feeding conditions. This study underscores the necessity of considering temporal dynamics of stress impacts and highlights the modulating effects of CORT. These insights contribute to a deeper understanding of the resilience mechanisms in motivational impairments and pave the way for further research into factors facilitating this resilience.</div></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"33 ","pages":"Article 100690"},"PeriodicalIF":4.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Neurobiology of Stress
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1