Neurobiology of Stress最新文献_第3页

Default mode network connectivity contributes the augment effect stress recovery by natural viewing 默认模式的网络连接有助于自然观察应力恢复的增强效应

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-09-12 DOI: 10.1016/j.ynstr.2025.100759

Zini Chen , Chanyu Wang , Timothea Toulopoulou , Xiayan Chen , Lijing Niu , Haowei Dai , Qingzi Zhu , Yuanyuan Zeng , Ruibin Zhang

The psychological benefits of exposure to natural environments are well established. However, whether simply viewing nature images produce similar restorative effects and the brain mechanisms involved remain unclear. For study purposes, we recruited 131 healthy university students and randomly assigned them to a nature image viewing group (NG) or a city image viewing group (CG), with 49 participants further selected (NG = 26, CG = 23) to undergo functional magnetic resonance imaging while performing behavioral tasks. First, we compared changes in subjective ratings and salivary cortisol levels, related to affect and stress between the NG and CG after stress induction and image viewing. Next, we examined differences in functional connectivity (FC) patterns of the default mode network (DMN) between the groups during image viewing. Finally, we explored correlations between the recovery effects observed after viewing nature images, along with alterations in FC. Under stress, NG participants reported greater changes in subjective ratings of positive affect (t = 2.610, p = 0.010), lower negative affect (t = −3.008, p = 0.003), and less state rumination (t = −2.103, p = 0.037). Neural data also suggest that connectivity of the DMN subsystems with attentional and executive regions plays a crucial role in modulating stress-related responses during natural experiences. Increased FC between the medial DMN subsystem and other networks was significantly correlated with behavioral recovery scores for both affect and state rumination. These findings indicate that viewing images of natural scenes can aid in stress recovery, highlighting the potential for indoor nature viewing to help mitigate psychological challenges faced in urban environments.

暴露在自然环境中的心理益处是公认的。然而，是否仅仅观看自然图像就能产生类似的恢复效果，以及其中涉及的大脑机制尚不清楚。为了研究目的，我们招募了131名健康的大学生，将他们随机分为自然图像观看组（NG）和城市图像观看组（CG），并进一步选择49名参与者（NG = 26, CG = 23）在执行行为任务时进行功能磁共振成像。首先，我们比较了应激诱导和图像观看后NG和CG之间与情绪和压力相关的主观评分和唾液皮质醇水平的变化。接下来，我们检查了两组在图像观看过程中默认模式网络（DMN）的功能连接（FC）模式的差异。最后，我们探讨了在观看自然图像后观察到的恢复效果与FC变化之间的相关性。在压力下，NG参与者报告了积极情绪主观评分的较大变化（t = 2.610, p = 0.010），消极情绪较低（t = - 3.008, p = 0.003），状态反思较少（t = - 2.103, p = 0.037）。神经数据还表明，DMN子系统与注意和执行区域的连通性在自然体验中调节压力相关反应中起着至关重要的作用。内侧DMN子系统与其他网络之间的FC增加与情绪反刍和状态反刍的行为恢复得分显著相关。这些发现表明，观看自然场景的图像可以帮助压力恢复，强调室内自然观看有助于减轻城市环境中面临的心理挑战的潜力。

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引用次数: 0

From intracellular sensors to systemic resilience: Reframing the biology of stress 从细胞内传感器到系统恢复力：重新构建压力生物学

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-09-09 DOI: 10.1016/j.ynstr.2025.100755

Jakob Hartmann

The biological consequences of chronic stress and trauma are complex, influencing multiple systems and contributing to the development of psychiatric disorders such as MDD and PTSD. Yet, the underlying molecular mechanisms that confer susceptibility in some individuals but resilience in others remain incompletely understood. To help close these knowledge gaps, my work centers on glucocorticoid signaling as a core mechanism underlying stress-related adaptations. This includes the glucocorticoid receptor (GR), its co-chaperones FKBP5 and FKBP4, and regulatory partners such as SKA2. Through a combination of genetic, viral, pharmacological, and transcriptomic approaches, my lab has delineated how these molecules influence HPA axis feedback, fear-related learning, and stress recovery. Recently, we identified a novel, GR-independent role for SKA2 in regulating secretory autophagy, a non-lytic autophagy pathway involved in vesicular cargo release, including cytokine secretion in microglia. These findings established a mechanistic link between intracellular stress signaling and neuroinflammatory responses. In a parallel line of research, we are investigating how chronic stress alters the gut microbiome composition and function, and how these changes impact behavior. Our aim is to harness dietary and probiotic interventions to restore homeostatic balance and enhance stress resilience. By integrating molecular neuroscience with immune and microbiome research, my long-term goal is to build a comprehensive, systems-level model of stress vulnerability and resilience. This approach holds promise for identifying novel biomarkers and therapeutic targets that support mental health and resilience across the lifespan.

慢性应激和创伤的生物学后果是复杂的，影响多个系统，并有助于精神疾病的发展，如重度抑郁症和创伤后应激障碍。然而，在某些个体中赋予易感性而在另一些个体中赋予弹性的潜在分子机制仍然不完全清楚。为了帮助缩小这些知识差距，我的工作集中在糖皮质激素信号作为压力相关适应的核心机制上。这包括糖皮质激素受体（GR），其共同伴侣FKBP5和FKBP4，以及调控伙伴如SKA2。通过基因、病毒、药理学和转录组学方法的结合，我的实验室已经描绘了这些分子如何影响HPA轴反馈、恐惧相关的学习和压力恢复。最近，我们发现了SKA2在调节分泌性自噬中的一种新的、不依赖于gr的作用，这是一种参与小胶质细胞囊泡货物释放的非溶解性自噬途径，包括细胞因子的分泌。这些发现建立了细胞内应激信号和神经炎症反应之间的机制联系。在平行研究中，我们正在研究慢性压力如何改变肠道微生物组的组成和功能，以及这些变化如何影响行为。我们的目标是利用饮食和益生菌干预来恢复体内平衡和增强应激恢复能力。通过将分子神经科学与免疫和微生物组研究相结合，我的长期目标是建立一个全面的、系统级的压力脆弱性和恢复力模型。这种方法有望确定新的生物标志物和治疗靶点，以支持整个生命周期的心理健康和恢复能力。

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引用次数: 0

Transcriptomic profiles of susceptibility and resilience to stress in the amygdala and hippocampus of male rats 雄性大鼠杏仁核和海马体对应激的易感性和恢复力的转录组学特征

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-09-01 DOI: 10.1016/j.ynstr.2025.100754

Kimberly L.P. Long , Sandra E. Muroy , Siamak K. Sorooshyari , Mee Jung Ko , Yanabah Jaques , Kishant Mohan , Peter Sudmant , Daniela Kaufer

Traumatic experiences elicit a wide range of cognitive responses in both humans and animals, leading to diverse outcomes such as enhanced performance, cognitive impairment, or the development of mood and anxiety disorders like posttraumatic stress disorder (PTSD). A key challenge in understanding these varied responses is to decipher the underlying biological mechanisms that contribute to individual variability in trauma resilience or susceptibility. The purpose of this study was to elucidate the molecular bases for these differences, focusing on the amygdala and hippocampus—brain regions integral to stress responses. We exposed adult, male rats to an acute, severe stressor and profiled persistent anxiety-like behavior outcomes 7 days later. We investigated the transcriptional signatures in the basolateral amygdala and hippocampal dentate gyrus via bulk RNA sequencing from animals with behavioral outcomes indicative of stress resilience or vulnerability. Our results suggest that the basolateral amygdala and dentate gyrus display distinct transcriptomic changes following acute, severe stress. Furthermore, we identified specific region-dependent genes related to insulin signaling, neural plasticity, and stress responses that correlate with resilient and vulnerable phenotypes. Notably, a larger number of genes separated stress-resilient animals from both control and stress-susceptible animals, underscoring that an active molecular response, particularly in the hippocampus, facilitates protection from the long-term consequences of severe stress. These findings provide novel insight into the mechanisms that engender individual variability in the behavioral responses to stress and offer new targets for the advancement of therapies for stress-induced neuropsychiatric disorders.

创伤经历在人类和动物中引起广泛的认知反应，导致不同的结果，如表现增强、认知障碍或情绪和焦虑障碍的发展，如创伤后应激障碍（PTSD）。理解这些不同的反应的一个关键挑战是破译导致创伤恢复力或易感性个体差异的潜在生物学机制。本研究的目的是阐明这些差异的分子基础，重点研究杏仁核和海马体-大脑区域对应激反应的影响。我们将成年雄性大鼠暴露在急性、严重的压力源中，并在7天后对持续的焦虑样行为结果进行了分析。我们通过大量RNA测序研究了基底外侧杏仁核和海马齿状回的转录特征，这些转录特征来自具有应激恢复力或脆弱性行为结果的动物。我们的研究结果表明，基底外侧杏仁核和齿状回在急性严重应激后表现出明显的转录组变化。此外，我们确定了与胰岛素信号、神经可塑性和应激反应相关的特定区域依赖基因，这些基因与弹性和脆弱表型相关。值得注意的是，大量的基因将应激恢复动物与对照动物和应激易感动物分开，强调活跃的分子反应，特别是在海马体中，有助于保护动物免受严重应激的长期后果。这些发现为应激行为反应的个体差异机制提供了新的见解，并为应激性神经精神疾病的治疗提供了新的靶点。

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引用次数: 0

Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior 早期生活逆境和青少年基底外侧杏仁核活动对皮质边缘连通性和行为的交互影响

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-08-20 DOI: 10.1016/j.ynstr.2025.100753

Caitlyn R. Cody , Emilce Artur de la Villarmois , Anabel M.M. Miguelez Fernández , Janelle P. Lardizabal , Kuei Y. Tseng , Heather C. Brenhouse

Corticolimbic development is shaped by the environment and relies on coordinated neuronal activity. Prior work revealed that early life adversity (ELA) leads to hyperinnervation of basolateral amygdala (BLA) projections to the prefrontal cortex (PFC) beginning in early adolescence. Both ELA and corticolimbic hyperconnectivity are associated with anxiety-like behavior, however the underlying developmental processes driving these effects are largely unknown. Here we investigated interactive impacts of rearing environment and neuronal activity on behavior and corticolimbic connectivity in rats. We first found that BLA-PFC hyperinnervation was associated with enhanced BLA-evoked PFC local field potentials in adolescents exposed to maternal separation (MS) ELA. Since ELA reportedly increases activity in the early-developing BLA, we further examined whether reducing BLA activity during adolescence influences behavior or enduring PFC innervation. During early adolescence, MS animals displayed heightened exploratory behaviors in an open field. Differences between rearing groups were not present during acute inhibition of glutamatergic BLA neurons, as BLA inhibition resembled the effects of MS on adolescent exploratory behaviors. To examine longer-lasting impacts of adolescent BLA activity on PFC innervation, BLA-originating axonal boutons were quantified in the PFC during emerging adulthood after adolescent BLA inhibition. We expanded previous findings to show that MS causes enduring BLA-PFC hyperinnervation. Surprisingly, adolescent BLA inhibition itself increased BLA-PFC innervation in control animals, suggesting that hyperpolarization of output neurons during early adolescence may contribute to aberrant development of efferent projections. Taken together, our results indicate that ELA yields increased BLA-PFC innervation in adulthood that may involve enhanced inhibitory signaling within developing BLA circuitry.

皮质边缘的发育受环境影响，依赖于协调的神经元活动。先前的研究表明，早期生活逆境（ELA）导致青春期早期开始的基底外侧杏仁核（BLA）向前额皮质（PFC）投射的神经支配过度。ELA和皮质边缘超连通性都与焦虑样行为有关，然而驱动这些影响的潜在发育过程在很大程度上是未知的。本研究探讨了饲养环境和神经元活动对大鼠行为和皮质边缘连通性的交互影响。我们首先发现，暴露于母亲分离（MS） ELA的青少年中，BLA-PFC神经过度分布与bla诱发的PFC局部场电位增强有关。由于据报道ELA增加了早期发育的BLA的活动，我们进一步研究了青春期BLA活动的减少是否会影响行为或持久的PFC神经支配。在青春期早期，多发性硬化症动物在开放领域表现出更高的探索行为。在谷氨酸能BLA神经元的急性抑制中，饲养组之间不存在差异，因为BLA抑制类似于MS对青少年探索行为的影响。为了研究青少年BLA活性对PFC神经支配的长期影响，在青少年BLA抑制后的成年期，对PFC中起源于BLA的轴突钮扣进行了量化。我们扩展了先前的研究结果，表明MS导致持久的BLA-PFC神经过度支配。令人惊讶的是，青春期BLA抑制本身增加了对照动物的BLA- pfc神经支配，这表明青春期早期输出神经元的超极化可能导致传出投射的异常发育。综上所述，我们的研究结果表明，ELA在成年期增加了BLA- pfc神经的支配，这可能涉及BLA回路中抑制信号的增强。

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引用次数: 0

Sexual dimorphism in anxiety susceptibility: role of PNN maturation timing in the habenulo-interpeduncular reward circuits 焦虑易感性中的两性二态性：PNN成熟时间在habenul - interpotic奖赏回路中的作用

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-08-17 DOI: 10.1016/j.ynstr.2025.100750

Niels Fjerdingstad, Malalaniaina Rakotobe , Célia Leboulenger, Adrien Chopin, Thomas Lamonerie, Fabien D'Autréaux

引用次数: 0

Cardiometabolic and anxiogenic consequences of chronic social defeat stress in male mice 雄性小鼠慢性社会失败应激的心脏代谢和焦虑后果

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-08-13 DOI: 10.1016/j.ynstr.2025.100752

Karen A. Scott , Sophia A. Eikenberry , Khalid Elsaafien , Caitlin Baumer-Harrison , Dominique N. Johnson , Jéssica Matheus Sá , Alessandro Bartolomucci , Colin Sumners , Eric G. Krause , Annette D. de Kloet

Social adversity, such as that which occurs during subjugation to a lower social status, has profound psychological and cardiometabolic consequences that are conserved across species. Clinically, such adversity often arises from being of a lower socioeconomic status and may contribute to health disparities in cardiometabolic and affective disorders. To develop a better understanding of the cardiometabolic consequences of social adversity, we employ chronic social defeat stress (CSDS) in adult male mice. CSDS results in increases in body mass, that are accompanied by elevated lean and fluid mass, as well as several somatic indices of chronic stress. Moreover, mice exposed to CSDS exhibit increased anxiety-like behavior, spending more time in the closed arms of the elevated plus maze and less time in the center of an open field arena. Regarding cardiovascular parameters, initial social defeat sessions result in increases in blood pressure, activity, and temperature in comparison with control mice. Interestingly, while blood pressure returns to basal levels by the start of the light cycle for the first few days of defeat, 14 days of CSDS results in sustained elevations in blood pressure, lower activity and lower body temperature. Finally, the results of heart rate variability, spontaneous baroreflex sensitivity and adrenal transcriptome analyses were consistent with CSDS-induced autonomic dysfunction, effects that may contribute to the hypertension observed. Collectively, these data suggest that CSDS may be useful for modeling hypertension induced by chronic social stress, thereby enabling us to better understand the mechanisms that contribute to stress-induced cardiometabolic disease.

社会逆境，比如在社会地位低下时发生的逆境，具有深远的心理和心脏代谢影响，这种影响在物种中是保守的。在临床上，这种逆境往往源于较低的社会经济地位，并可能导致心脏代谢和情感疾病的健康差异。为了更好地理解社会逆境对心脏代谢的影响，我们在成年雄性小鼠中使用了慢性社会失败压力（CSDS）。CSDS导致体重增加，并伴有瘦肉和液体质量升高，以及一些慢性应激的躯体指标。此外，暴露于CSDS的小鼠表现出更多的焦虑样行为，在高架+迷宫的封闭手臂中花费更多的时间，而在开放场地中心的时间更少。在心血管参数方面，与对照组小鼠相比，最初的社交失败会导致血压、活动和体温升高。有趣的是，虽然在失败的最初几天，血压会在光周期开始时恢复到基础水平，但14天的CSDS会导致血压持续升高，活动减少和体温降低。最后，心率变异性、自发性压力反射敏感性和肾上腺转录组分析的结果与csds诱导的自主神经功能障碍一致，这些影响可能有助于观察到的高血压。综上所述，这些数据表明CSDS可能对慢性社会压力诱导的高血压建模有用，从而使我们能够更好地理解压力诱导的心脏代谢疾病的机制。

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引用次数: 0

Not just a witness: Highlighting the utility of witness social defeat stress for the examination of neuroimmune-cardiovascular interactions across diverse populations 不仅仅是一个证人：强调证人社会失败压力在不同人群中神经免疫-心血管相互作用检查中的效用

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-08-12 DOI: 10.1016/j.ynstr.2025.100751

Margherita Barbetti , Cora E. Smiley , Monia Savi , Andrea Sgoifo , Susan K. Wood , Luca Carnevali

Exposure to stress has widespread pathological consequences in terms of neuropsychiatric disorders and cardiovascular disease. Psychosocial stressors represent the most highly impactful and commonly experienced form of stress and, in preclinical studies, have been found to induce distinct overlapping immune and cardiovascular alterations. Historically, the social defeat model has been fundamental in providing insights into the autonomic and neuroimmune mediators of cardiovascular dysfunction in the face of social stress exposure. However, this procedure relies on aggressive, physical interaction between rodents and is limited by its almost exclusive application to young adult males. This challenges the possibility of using social defeat to generate data in rodents that can be translated into social stress-related processes in both men and women across the lifespan. More recently, a novel vicarious social defeat procedure has been developed, wherein a rodent bears witness to an aggressive social defeat encounter between two males from the safety of an adjacent compartment. This review first discusses the existing data regarding stress-induced cardiovascular alterations and the underlying autonomic and neuroimmune mediators of social defeat while critically discussing the limitations of this model. New prospects are then offered based on recent findings across a diverse population of rodent species, sexes, and ages to support the use of vicarious/witness social defeat model as an optimal strategy to investigate social stress-related autonomic, neuroimmune, and cardiovascular processes using more comprehensive and inclusive methods.

暴露于压力在神经精神疾病和心血管疾病方面具有广泛的病理后果。心理社会压力源是最具影响力和最常见的压力形式，在临床前研究中，已发现可诱导明显重叠的免疫和心血管改变。从历史上看，社会失败模型在提供面对社会压力暴露时心血管功能障碍的自主神经和神经免疫介质的见解方面是基础的。然而，这种方法依赖于啮齿动物之间的攻击性身体相互作用，并且几乎只适用于年轻的成年雄性，因此受到限制。这挑战了利用社会失败在啮齿动物中产生数据的可能性，这些数据可以转化为男性和女性一生中与社会压力相关的过程。最近，一种新的替代性社会失败程序被开发出来，其中一只啮齿动物从相邻的安全隔间见证了两只雄性动物之间的攻击性社会失败遭遇。这篇综述首先讨论了关于压力诱导的心血管改变和潜在的自主神经和神经免疫介质的现有数据，同时批判性地讨论了该模型的局限性。基于最近对不同啮齿动物种群、性别和年龄的研究结果，研究人员提供了新的前景，以支持将替代/见证社会失败模型作为一种最佳策略，使用更全面和包容的方法来研究与社会压力相关的自主神经、神经免疫和心血管过程。

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引用次数: 0

Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities 产前应激在不同gaba能人群中引起短暂的发育改变，并导致长期的行为异常

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-08-06 DOI: 10.1016/j.ynstr.2025.100749

Keren Shoshani-Haye , Gilgi Friedlander , Ofra Golani , Suellen Almeida-Correa , Yair Shemesh , Alon Chen

Prenatal stress (PNS) is a well-established risk factor for psychiatric disorders, yet the underlying neurobiological mechanisms remain unclear. Here, we demonstrate that PNS induces long-term behavioral abnormalities, including increased anxiety- and depressive-like behaviors specifically in adult male mice. To investigate potential neurodevelopmental disruptions, we analyzed the medial prefrontal cortex (mPFC) at key postnatal stages. RNA sequencing at postnatal day 1 (P1) revealed significant transcriptional changes, particularly in genes associated with neuronal migration and differentiation, with a diminished effect by P14. Histological analysis identified a transient imbalance in inhibitory neuron subpopulations, PNS decreased the density of early-born neurons derived from the medial ganglionic eminence (MGE) while increasing late-born neurons derived from the caudal ganglionic eminence (CGE) at P1. EdU labeling confirmed that these shifts were time- and subtype-specific, affecting inhibitory neuron proliferation at distinct embryonic stages. By P15, these neuroanatomical alterations largely resolved, yet behavioral abnormalities persisted into adulthood. Our findings suggest that PNS disrupts inhibitory neuron development during a critical early window, leading to lasting behavioral consequences despite the transient nature of anatomical changes. This study highlights the selective vulnerability of inhibitory neuron subtypes to early-life stress and provides insight into potential mechanisms underlying stress-related psychiatric disorders.

产前应激（PNS）是一个公认的精神疾病风险因素，但其潜在的神经生物学机制尚不清楚。在这里，我们证明PNS诱导长期行为异常，包括增加焦虑和抑郁样行为，特别是在成年雄性小鼠中。为了研究潜在的神经发育障碍，我们分析了出生后关键阶段的内侧前额叶皮层（mPFC）。出生后第1天（P1）的RNA测序显示了显著的转录变化，特别是与神经元迁移和分化相关的基因，P14的影响减弱。组织学分析证实了抑制性神经元亚群的一过性失衡，PNS降低了内侧神经节隆起（MGE）的早生神经元密度，而增加了P1时尾神经节隆起（CGE）的晚生神经元密度。EdU标记证实这些变化是时间和亚型特异性的，影响不同胚胎阶段的抑制性神经元增殖。到了P15，这些神经解剖学上的改变在很大程度上得到了解决，但行为异常会持续到成年期。我们的研究结果表明，PNS在关键的早期窗口期破坏抑制性神经元的发育，导致持久的行为后果，尽管解剖变化是短暂的。这项研究强调了抑制神经元亚型对早期生活压力的选择性脆弱性，并为压力相关精神疾病的潜在机制提供了见解。

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引用次数: 0

Deep brain stimulation changes locus coeruleus responses to social stress from activation to inhibition. 脑深部刺激改变蓝斑对社会压力的反应从激活到抑制。

IF 3.6 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-07-23 eCollection Date: 2025-09-01 DOI: 10.1016/j.ynstr.2025.100745

Sonia Torres-Sanchez, Andre L Curtis, Rita J Valentino, Esther Berrocoso

Deep Brain Stimulation (DBS) of the subgenual cingulate cortex (SCC) stands as an innovative therapeutic approach for treatment-resistant depression. Previous preclinical investigations utilizing DBS targeted at the ventromedial prefrontal cortex (vmPFC), considered the rodent equivalent of the human SCC, have demonstrated antidepressant-like effects, as well as enhancement in the activity of the locus coeruleus (LC)-norepinephrine (NE) system and pontine-cortical network oscillations. Given the association between social stress and depression and other psychiatric disorders, we assessed the impact of vmPFC DBS on social stress-induced changes in LC neuronal activity in awake rats. Spontaneous and auditory-evoked LC single unit activity were compared between control and DBS male rats during the first (acute) and fifth (repeated) day of social defeat stress. In stark contrast to LC activation observed in controls, both acute and repeated stress robustly inhibited LC neurons of DBS rats. While both groups experienced an acute stress-induced reduction in auditory-evoked LC discharge, the duration of the evoked response was only decreased in control animals. LC auditory-evoked activity was increased after repeated stress and DBS effectively counteracted these stress-induced alterations. These findings suggest that DBS treatment shifts stress-induced regulation of LC activity such that it favors the engagement of inhibitory modulation. This may serve to promote resistance of the LC-NE system to stress-induced excitation and contribute to the mitigation of neuropsychiatric consequences of stress.

深部脑刺激（DBS）的亚属扣带皮层（SCC）是一种创新的治疗方法治疗难治性抑郁症。先前的临床前研究利用DBS靶向腹内侧前额叶皮层（vmPFC），被认为是相当于人类SCC的啮齿动物，已经证明了抗抑郁样的作用，以及蓝斑(LC)-去甲肾上腺素（NE）系统和桥脑皮层网络振荡的活性增强。鉴于社会压力与抑郁和其他精神疾病之间的关联，我们评估了vmPFC DBS对清醒大鼠社会压力诱导的LC神经元活动变化的影响。比较对照和DBS雄性大鼠在社会失败应激的第1天（急性）和第5天（重复）时自发性和听觉诱发的LC单单位活性。与对照组相比，急性应激和反复应激对DBS大鼠LC神经元均有明显抑制作用。虽然两组都经历了急性应激性听觉诱发的LC放电减少，但诱发反应的持续时间仅在对照动物中减少。反复应激后LC听觉诱发的活动增加，DBS有效地抵消了这些应激引起的改变。这些发现表明，DBS治疗改变了应激诱导的LC活性调节，使其有利于抑制调节的参与。这可能有助于促进LC-NE系统对应激性兴奋的抵抗，并有助于减轻应激的神经精神后果。

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引用次数: 0

Interhemispheric Effects of iTBS on the Fronto-Parietal Network: Evidence from Dual-Site Stimulation iTBS对额顶叶网络的半球间影响：来自双部位刺激的证据

IF 4.3 2区医学 Q1 NEUROSCIENCES

Neurobiology of Stress

Pub Date : 2025-07-10 DOI: 10.1016/j.ynstr.2025.100744

Isabell Int-Veen , Beatrix Barth , Ramona Täglich , Betti Schopp , Hans-Christoph Nuerk , Christian Plewnia , Stefanie De Smet , Marie-Anne Vanderhasselt , Andreas J. Fallgatter , Ann-Christine Ehlis , David Rosenbaum

This study investigated the neuromodulatory effects of Theta Burst Stimulation (TBS) on resting-state functional connectivity (FC) following psychosocial stress induced by the Trier Social Stress Test (TSST). Given its key role in cognitive control and emotion regulation — processes highly relevant for rumination — we focused on the frontoparietal network. Across two studies, intermittent (iTBS) and continuous (cTBS) protocols were applied to the left Dorsolateral Prefrontal Cortex (DLPFC; study 1) and right Ventrolateral Prefrontal Cortex (VLPFC; study 2) prior to stress induction. Functional Near-Infrared Spectroscopy (fNIRS) was used to assess neural changes. A total of 88 (study 1) and 89 (study 2) healthy participants were recruited, balanced for low and high trait rumination. Each participant received both active and sham TBS (iTBS or cTBS), in a randomized, counterbalanced design. Results indicated that iTBS elicited excitatory effects on prefrontal and fronto-parietal connectivity, whereas cTBS effects were more variable. Trait rumination emerged as a modulator of TBS effects: In study 1, significant interactions for FC between the right VLPFC and Somatosensory Association Cortex (SAC) when stimulating the left DLPFC emerged, while study 2 revealed similar interactions for FC between the left DLPFC and SAC and intra-SAC FC when stimulating the right VLPFC. Correlations between post-stress state rumination and FC changes further support these findings. These results underscore the importance of neural assessments in TBS research and highlight the complexity of individual differences in state and trait rumination. Understanding the interplay between TBS, fronto-parietal connectivity, and rumination may provide valuable insights into personalized neuromodulation strategies.

本研究探讨了Theta Burst Stimulation （TBS）对Trier Social stress Test （TSST）诱导的心理社会应激后静息状态功能连通性（FC）的神经调节作用。鉴于其在认知控制和情绪调节（与反刍高度相关的过程）中的关键作用，我们将重点放在了额顶叶网络上。在两项研究中，间歇（iTBS）和连续（cTBS）方案应用于左背外侧前额叶皮层(DLPFC；研究1)和右侧腹外侧前额叶皮层（VLPFC）；研究2)应力诱导前。功能近红外光谱（fNIRS）评估神经变化。共招募了88名（研究1）和89名（研究2）健康参与者，平衡了低特质反刍和高特质反刍。在一个随机、平衡的设计中，每个参与者都接受了主动和假TBS （iTBS或cTBS）。结果表明，iTBS对前额叶和额顶叶连通性有兴奋作用，而cTBS对前额叶和额顶叶连通性的影响变化较大。特质反刍是TBS效应的调节因子：在研究1中，当刺激左侧DLPFC时，右侧VLPFC与躯体感觉关联皮层（SAC）之间出现了显著的FC相互作用，而研究2显示，当刺激右侧VLPFC时，左侧DLPFC与SAC和SAC内FC之间也出现了类似的FC相互作用。应激后状态反刍与FC变化之间的相关性进一步支持了这些发现。这些结果强调了神经评估在TBS研究中的重要性，并强调了状态和特质反刍个体差异的复杂性。了解TBS、额顶叶连接和反刍之间的相互作用可能为个性化神经调节策略提供有价值的见解。

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