Pub Date : 2025-01-01Epub Date: 2024-12-06DOI: 10.1016/j.neucli.2024.103031
Agnès JACQUIN-PIQUES
Food pleasantness is largely based on the palatability of food and is linked to taste. Along with homeostatic and cognitive control, it forms part of the control of food intake (hedonic control), and does not only correspond to the pleasure that can be described of food intake. There are many factors that cause variations in eating pleasantness between individuals, such as age, sex, culture, co-morbidities, treatments, environmental factors or the specific characteristics of foods. The control of food intake is based on four determinants: conditioned satiety, the reward system, sensory specific satiety and alliesthesia. These four determinants follow one another over time, in the per-prandial and inter-prandial periods, and complement one another. There are many cerebral areas involved in the hedonic control of food intake. The most involved brain areas are the orbitofrontal and anterior cingulate cortices, which interact with deep neural structures (amygdala, striatum, substantia nigra) for the reward circuit, with the hippocampi for memorising pleasant foods, and even with the hypothalamus and insula, brain areas more recently involved in the physiology of food pleasantness. Changes in brain activity secondary to modulation of food pleasantness can be measured objectively by recording taste-evoked potentials, an electroencephalography technique with very good temporal resolution.
{"title":"The pleasantness of foods","authors":"Agnès JACQUIN-PIQUES","doi":"10.1016/j.neucli.2024.103031","DOIUrl":"10.1016/j.neucli.2024.103031","url":null,"abstract":"<div><div>Food pleasantness is largely based on the palatability of food and is linked to taste. Along with homeostatic and cognitive control, it forms part of the control of food intake (hedonic control), and does not only correspond to the pleasure that can be described of food intake. There are many factors that cause variations in eating pleasantness between individuals, such as age, sex, culture, co-morbidities, treatments, environmental factors or the specific characteristics of foods. The control of food intake is based on four determinants: conditioned satiety, the reward system, sensory specific satiety and alliesthesia. These four determinants follow one another over time, in the per-prandial and inter-prandial periods, and complement one another. There are many cerebral areas involved in the hedonic control of food intake. The most involved brain areas are the orbitofrontal and anterior cingulate cortices, which interact with deep neural structures (amygdala, striatum, substantia nigra) for the reward circuit, with the hippocampi for memorising pleasant foods, and even with the hypothalamus and insula, brain areas more recently involved in the physiology of food pleasantness. Changes in brain activity secondary to modulation of food pleasantness can be measured objectively by recording taste-evoked potentials, an electroencephalography technique with very good temporal resolution.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 1","pages":"Article 103031"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-12-21DOI: 10.1016/j.neucli.2024.103035
Mariana Lopes Martins , Melyssa Kellyane Cavalcanti Galdino , Daniel Soares Ferreira Silva , Eliza Carolina Dantas Valença , Mariana Braz dos Santos , Jessica Figueiredo de Medeiros , Daniel Gomes da Silva Machado , Marine Raquel Diniz da Rosa
{"title":"Standalone tDCS for tinnitus treatment: Is it a good choice?","authors":"Mariana Lopes Martins , Melyssa Kellyane Cavalcanti Galdino , Daniel Soares Ferreira Silva , Eliza Carolina Dantas Valença , Mariana Braz dos Santos , Jessica Figueiredo de Medeiros , Daniel Gomes da Silva Machado , Marine Raquel Diniz da Rosa","doi":"10.1016/j.neucli.2024.103035","DOIUrl":"10.1016/j.neucli.2024.103035","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 1","pages":"Article 103035"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-01-06DOI: 10.1016/j.neucli.2024.103041
Laura Tassi , Veronica Pelliccia , Francesca Bisulli , Matteo Martinoni , Lorenzo Ferri , Flavio Giordano , Federico Melani , Luca de Palma , Nicola Specchio , Carlo Efisio Marras , Francesco Cardinale , Carmen Barba
Stereo-EEG is not just a diagnostic examination but a complex methodology, requiring an accurate synthesis of many data (anatomical, clinical, neurophysiological, cognitive, metabolic, and genetic). The implantation scheme is decided based on a hypothesis (or hypotheses) of epileptogenic zone localization. Subsequently, intracerebral electrical stimulation is used to define the extent of highly functional cortical regions and to reproduce the clinical symptoms and signs associated with seizures. Finally, stereo-EEG-guided thermocoagulation is used, with the dual purpose of stopping/reducing the seizures and determining the prognosis of possible resective (curative) surgery. The centers in Italy that use stereo-EEG derive from the French school of Bancaud and Talairach. Nevertheless, each one has interpreted, on the basis of its own specificity and talent, a new methodology and philosophy of implantation. The present work presents the state of the art of stereo-EEG use in Italy, with detail of the stereo-EEG program of the Munari center in Milano, as well as those of Florence, Bologna and Rome.
{"title":"Stereo-EEG around the world: State of the art in Italy","authors":"Laura Tassi , Veronica Pelliccia , Francesca Bisulli , Matteo Martinoni , Lorenzo Ferri , Flavio Giordano , Federico Melani , Luca de Palma , Nicola Specchio , Carlo Efisio Marras , Francesco Cardinale , Carmen Barba","doi":"10.1016/j.neucli.2024.103041","DOIUrl":"10.1016/j.neucli.2024.103041","url":null,"abstract":"<div><div>Stereo-EEG is not just a diagnostic examination but a complex methodology, requiring an accurate synthesis of many data (anatomical, clinical, neurophysiological, cognitive, metabolic, and genetic). The implantation scheme is decided based on a hypothesis (or hypotheses) of epileptogenic zone localization. Subsequently, intracerebral electrical stimulation is used to define the extent of highly functional cortical regions and to reproduce the clinical symptoms and signs associated with seizures. Finally, stereo-EEG-guided thermocoagulation is used, with the dual purpose of stopping/reducing the seizures and determining the prognosis of possible resective (curative) surgery. The centers in Italy that use stereo-EEG derive from the French school of Bancaud and Talairach. Nevertheless, each one has interpreted, on the basis of its own specificity and talent, a new methodology and philosophy of implantation. The present work presents the state of the art of stereo-EEG use in Italy, with detail of the stereo-EEG program of the Munari center in Milano, as well as those of Florence, Bologna and Rome.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 1","pages":"Article 103041"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2024-12-10DOI: 10.1016/j.neucli.2024.103034
Hinpetch Daungsupawong , Viroj Wiwanitkit
{"title":"Letter in response to Martins et al., tDCS for tinnitus modulation","authors":"Hinpetch Daungsupawong , Viroj Wiwanitkit","doi":"10.1016/j.neucli.2024.103034","DOIUrl":"10.1016/j.neucli.2024.103034","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 1","pages":"Article 103034"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-10-25DOI: 10.1016/j.neucli.2024.103020
Mariana Lopes Martins , Melyssa Kellyane Cavalcanti Galdino , Daniel Soares Ferreira Silva , Eliza Carolina Dantas Valença , Mariana Braz dos Santos , Jessica Figueiredo de Medeiros , Daniel Gomes da Silva Machado , Marine Raquel Diniz da Rosa
Objectives
To evaluate the short and long-term effects of anodal tDCS (a-tDCS) targeting the left temporoparietal area (LTA) on tinnitus severity, annoyance, and loudness.
Methods
This is a double-blind, randomized, sham-controlled, and parallel-group clinical trial. A total of 42 individuals with tinnitus were randomized to a-tDCS (n = 24) or sham tDCS (n = 18). The a-tDCS group received tDCS over the LTA during five consecutive day sessions (2 mA, 20 min). The sham group received a placebo current with the same characteristics as the a-tDCS group. Participants were assessed at baseline, after the fifth session, and at the 30-day follow-up, using hearing assessments and symptom questionnaires.
Results
There was no effect of comparison between groups or interaction effect (time x group) in all hearing assessments and symptom questionnaires. There was only a main effect of time for Tinnitus Handicap Inventory - THI [F(1.642, 45.988) = 5.128; p = 0.014; η2 = 0.155]. Bonferroni post hoc showed that there was a significant difference in THI in the sham group between pre and post-treatment [CI (0.107, 14.643; p = 0.046)]. However, there was no difference between pre-treatment and follow-up THI, or between post-treatment and follow-up THI. There was no treatment effect on tinnitus severity (assessed by Tinnitus Functional Inventory - TFI), tinnitus annoyance or loudness (assessed by Visual Analogue Scale - VAS), or tinnitus pitch, loudness or minimum masking level (assessed by tinnitometry).
Conclusion
Five consecutive sessions of a-tDCS targeting LTA do not improve tinnitus severity, annoyance, and loudness. Future studies should investigate if other tDCS protocols are effective or a combination of tDCS with other forms of treatment.
目的评估以左侧颞顶区（LTA）为靶点的阳极tDCS（a-tDCS）对耳鸣严重程度、烦恼和响度的短期和长期影响：这是一项双盲、随机、假对照和平行组临床试验。共有 42 名耳鸣患者被随机分配到 a-tDCS 组（24 人）或假 tDCS 组（18 人）。a-tDCS组连续五天在LTA上接受tDCS治疗（2毫安，20分钟）。假电流组接受与 a-tDCS 组相同的安慰剂电流。在基线、第五次治疗后和 30 天随访时，使用听力评估和症状问卷对参与者进行评估：结果：在所有听力评估和症状问卷调查中，组间比较或交互效应（时间 x 组）均无影响。只有耳鸣障碍量表（THI）存在时间主效应[F（1.642，45.988）=5.128；p=0.014；η2=0.155]。Bonferroni post hoc 显示，假治疗组的 THI 在治疗前和治疗后有显著差异 [CI (0.107, 14.643; p = 0.046)]。但是，治疗前和治疗后的 THI 之间以及治疗后和治疗后的 THI 之间没有差异。治疗对耳鸣严重程度（通过耳鸣功能量表评估）、耳鸣烦扰度或响度（通过视觉模拟量表评估）、耳鸣音高、响度或最低掩蔽水平（通过耳鸣测量法评估）均无影响：结论：以 LTA 为目标的连续五次 a-tDCS 治疗并不能改善耳鸣的严重程度、烦扰度和响度。未来的研究应探讨其他 tDCS 方案是否有效，或将 tDCS 与其他治疗方式相结合。
{"title":"Effect of transcranial direct current stimulation on tinnitus modulation: A randomized, double-blind, and placebo-controlled clinical trial","authors":"Mariana Lopes Martins , Melyssa Kellyane Cavalcanti Galdino , Daniel Soares Ferreira Silva , Eliza Carolina Dantas Valença , Mariana Braz dos Santos , Jessica Figueiredo de Medeiros , Daniel Gomes da Silva Machado , Marine Raquel Diniz da Rosa","doi":"10.1016/j.neucli.2024.103020","DOIUrl":"10.1016/j.neucli.2024.103020","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the short and long-term effects of anodal tDCS (a-tDCS) targeting the left temporoparietal area (LTA) on tinnitus severity, annoyance, and loudness.</div></div><div><h3>Methods</h3><div>This is a double-blind, randomized, sham-controlled, and parallel-group clinical trial. A total of 42 individuals with tinnitus were randomized to a-tDCS (<em>n</em> = 24) or sham tDCS (<em>n</em> = 18). The a-tDCS group received tDCS over the LTA during five consecutive day sessions (2 mA, 20 min). The sham group received a placebo current with the same characteristics as the a-tDCS group. Participants were assessed at baseline, after the fifth session, and at the 30-day follow-up, using hearing assessments and symptom questionnaires.</div></div><div><h3>Results</h3><div>There was no effect of comparison between groups or interaction effect (time x group) in all hearing assessments and symptom questionnaires. There was only a main effect of time for Tinnitus Handicap Inventory - THI [F(1.642, 45.988) = 5.128; <em>p</em> = 0.014; η<sup>2</sup> = 0.155]. Bonferroni post hoc showed that there was a significant difference in THI in the sham group between pre and post-treatment [CI (0.107, 14.643; <em>p</em> = 0.046)]. However, there was no difference between pre-treatment and follow-up THI, or between post-treatment and follow-up THI. There was no treatment effect on tinnitus severity (assessed by Tinnitus Functional Inventory - TFI), tinnitus annoyance or loudness (assessed by Visual Analogue Scale - VAS), or tinnitus pitch, loudness or minimum masking level (assessed by tinnitometry).</div></div><div><h3>Conclusion</h3><div>Five consecutive sessions of a-tDCS targeting LTA do not improve tinnitus severity, annoyance, and loudness. Future studies should investigate if other tDCS protocols are effective or a combination of tDCS with other forms of treatment.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 6","pages":"Article 103020"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-09-07DOI: 10.1016/j.neucli.2024.103010
Yan Wang , Jiajia Yang , Wei Wang , Xin Zhou, Xuefeng Wang, Jing Luo, Feng Li
Objectives
To explore the factors associated with poor prognosis in critically ill patients with Electroencephalogram (EEG) patterns exhibiting stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs), and to construct a prognostic prediction model.
Methods
This study included a total of 53 critically ill patients with EEG patterns exhibiting SIRPIDs who were admitted to the First Affiliated Hospital of Chongqing Medical University from May 2023 to March 2024. Patients were divided into two groups based on their Modified Rankin Scale (mRS) scores at discharge: good prognosis group (0–3 points) and poor prognosis group (4–6 points). Retrospective analyses were performed on the clinical and EEG parameters of patients in both groups. Logistic regression analysis was applied to identify the risk factors related to poor prognosis in critically ill patients with EEG patterns exhibiting SIRPIDs; a risk prediction model for poor prognosis was constructed, along with an individualized predictive nomogram model, and the predictive performance and consistency of the model were evaluated.
Results
Multivariate logistic regression analysis revealed that APACHE II score (OR=1.217, 95 %CI=1.030∼1.438), slow frequency bands or no obvious brain electrical activity (OR=8.720, 95 %CI=1.220∼62.313), and no sleep waveforms (OR=9.813, 95 %CI=1.371∼70.223) were independent risk factors for poor prognosis in patients. A regression model established based on multivariate logistic regression analysis had an area under the curve of 0.902. The model's accuracy was 90.60 %, with a sensitivity of 92.86 % and a specificity of 89.70 %. The nomogram model, after internal validation, showed a concordance index of 0.904.
Conclusions
A high APACHE II score, EEG patterns with slow frequency bands or no obvious brain electrical activity, and no sleep waveforms were independent risk factors for poor prognosis in patients with SIRPIDs. The nomogram model constructed based on these factors had a favorably high level of accuracy in predicting the risk of poor prognosis and held certain reference and application value for clinical neurofunctional assessment and prognostic determination.
{"title":"A novel nomogram for predicting the prognosis of critically ill patients with EEG patterns exhibiting stimulus-induced rhythmic, periodic, or ictal discharges","authors":"Yan Wang , Jiajia Yang , Wei Wang , Xin Zhou, Xuefeng Wang, Jing Luo, Feng Li","doi":"10.1016/j.neucli.2024.103010","DOIUrl":"10.1016/j.neucli.2024.103010","url":null,"abstract":"<div><h3>Objectives</h3><p>To explore the factors associated with poor prognosis in critically ill patients with Electroencephalogram (EEG) patterns exhibiting stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs), and to construct a prognostic prediction model.</p></div><div><h3>Methods</h3><p>This study included a total of 53 critically ill patients with EEG patterns exhibiting SIRPIDs who were admitted to the First Affiliated Hospital of Chongqing Medical University from May 2023 to March 2024. Patients were divided into two groups based on their Modified Rankin Scale (mRS) scores at discharge: good prognosis group (0–3 points) and poor prognosis group (4–6 points). Retrospective analyses were performed on the clinical and EEG parameters of patients in both groups. Logistic regression analysis was applied to identify the risk factors related to poor prognosis in critically ill patients with EEG patterns exhibiting SIRPIDs; a risk prediction model for poor prognosis was constructed, along with an individualized predictive nomogram model, and the predictive performance and consistency of the model were evaluated.</p></div><div><h3>Results</h3><p>Multivariate logistic regression analysis revealed that APACHE II score (OR=1.217, 95 %CI=1.030∼1.438), slow frequency bands or no obvious brain electrical activity (OR=8.720, 95 %CI=1.220∼62.313), and no sleep waveforms (OR=9.813, 95 %CI=1.371∼70.223) were independent risk factors for poor prognosis in patients. A regression model established based on multivariate logistic regression analysis had an area under the curve of 0.902. The model's accuracy was 90.60 %, with a sensitivity of 92.86 % and a specificity of 89.70 %. The nomogram model, after internal validation, showed a concordance index of 0.904.</p></div><div><h3>Conclusions</h3><p>A high APACHE II score, EEG patterns with slow frequency bands or no obvious brain electrical activity, and no sleep waveforms were independent risk factors for poor prognosis in patients with SIRPIDs. The nomogram model constructed based on these factors had a favorably high level of accuracy in predicting the risk of poor prognosis and held certain reference and application value for clinical neurofunctional assessment and prognostic determination.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 6","pages":"Article 103010"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-09-10DOI: 10.1016/j.neucli.2024.103007
S. Dionisio , I. Althubaiti , M. Aldosari , F Alsallom , N. Alomar , F. Babtain , A. Alkhotani , S. Baeesa , A. Najjar , A. Sabbagh , Z. Althani , F. Alotaibi , K. Alqadi
Epilepsy surgery and intracranial monitoring have a long history in the Kingdom of Saudi Arabia, spanning over 30 years. Stereo-EEG however, is a more recent offering. In this short communication, we discuss how Stereo-EEG has grown in the context of the Kingdom's healthcare model and the Vision 2030 model. We discuss the various positives of this technique and methodology as well as the various challenges that the hospitals offering Stereo-EEG have faced.
{"title":"Stereo electroencephalography in the kingdom of Saudi Arabia","authors":"S. Dionisio , I. Althubaiti , M. Aldosari , F Alsallom , N. Alomar , F. Babtain , A. Alkhotani , S. Baeesa , A. Najjar , A. Sabbagh , Z. Althani , F. Alotaibi , K. Alqadi","doi":"10.1016/j.neucli.2024.103007","DOIUrl":"10.1016/j.neucli.2024.103007","url":null,"abstract":"<div><p>Epilepsy surgery and intracranial monitoring have a long history in the Kingdom of Saudi Arabia, spanning over 30 years. Stereo-EEG however, is a more recent offering. In this short communication, we discuss how Stereo-EEG has grown in the context of the Kingdom's healthcare model and the Vision 2030 model. We discuss the various positives of this technique and methodology as well as the various challenges that the hospitals offering Stereo-EEG have faced.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 6","pages":"Article 103007"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01Epub Date: 2024-09-07DOI: 10.1016/j.neucli.2024.103011
Francis Houde , Russell Butler , Etienne St-Onge , Marylie Martel , Véronique Thivierge , Maxime Descoteaux , Kevin Whittingstall , Guillaume Leonard
Objective
Explore how anatomical measurements and field modeling can be leveraged to improve investigations of transcranial magnetic stimulation (TMS) effects on both motor and non-motor TMS targets.
Methods
TMS motor effects (targeting the primary motor cortex [M1]) were evaluated using the resting motor threshold (rMT), while TMS non-motor effects (targeting the superior temporal gyrus [STG]) were assessed using a pain memory task. Anatomical measurements included scalp-cortex distance (SCD) and cortical thickness (CT), whereas field modeling encompassed the magnitude of the electric field (E) induced by TMS.
Results
Anatomical measurements and field modeling values differed significantly between M1 and STG. For TMS motor effects, rMT was correlated with SCD, CT, and E values at M1 (p < 0.05). No correlations were found between these metrics for the STG and TMS non-motor effects (pain memory; all p-values > 0.05).
Conclusion
Although anatomical measurements and field modeling are closely related to TMS motor effects, their relationship to non-motor effects – such as pain memory – appear to be much more tenuous and complex, highlighting the need for further advancement in our use of TMS and virtual lesion paradigms.
{"title":"Anatomical measurements and field modeling to assess transcranial magnetic stimulation motor and non-motor effects","authors":"Francis Houde , Russell Butler , Etienne St-Onge , Marylie Martel , Véronique Thivierge , Maxime Descoteaux , Kevin Whittingstall , Guillaume Leonard","doi":"10.1016/j.neucli.2024.103011","DOIUrl":"10.1016/j.neucli.2024.103011","url":null,"abstract":"<div><h3>Objective</h3><p>Explore how anatomical measurements and field modeling can be leveraged to improve investigations of transcranial magnetic stimulation (TMS) effects on both motor and non-motor TMS targets.</p></div><div><h3>Methods</h3><p>TMS motor effects (targeting the primary motor cortex [M1]) were evaluated using the resting motor threshold (rMT), while TMS non-motor effects (targeting the superior temporal gyrus [STG]) were assessed using a pain memory task. Anatomical measurements included scalp-cortex distance (SCD) and cortical thickness (CT), whereas field modeling encompassed the magnitude of the electric field (E) induced by TMS.</p></div><div><h3>Results</h3><p>Anatomical measurements and field modeling values differed significantly between M1 and STG. For TMS motor effects, rMT was correlated with SCD, CT, and E values at M1 (<em>p</em> < 0.05). No correlations were found between these metrics for the STG and TMS non-motor effects (pain memory; all p-values > 0.05).</p></div><div><h3>Conclusion</h3><p>Although anatomical measurements and field modeling are closely related to TMS motor effects, their relationship to non-motor effects – such as pain memory – appear to be much more tenuous and complex, highlighting the need for further advancement in our use of TMS and virtual lesion paradigms.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 6","pages":"Article 103011"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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