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Critical windows of susceptibility for the effects of prenatal exposure to heat and heat variability on gestational growth 产前热暴露和热变异性对妊娠生长影响的敏感性关键窗口
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107454
Jeffrey Carlson
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引用次数: 0
Co-occurring substance use and mental health symptoms among prenatally substance-exposed emerging adults 在产前物质暴露的新生成人中共同发生的物质使用和精神健康症状
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107498
June-Yung Kim , Sonia Minnes , Meeyoung O. Min , Liat R. Johnson , Lynn T. Singer
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引用次数: 0
Neurobehavioral assessments in preterm pigs 早产儿神经行为评估
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107489
Helen J.K. Sable
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引用次数: 0
Regulatory aspects of neurobehavioral testing in alternate animal models 在替代动物模型中神经行为测试的调节方面
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107490
Elizabeth Green
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引用次数: 0
A new ethical paradigm challenged: Reproductive research in the post-Dobbs era 挑战新的伦理范式:后多布斯时代的生殖研究
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107477
Anne D. Lyerly
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引用次数: 0
Evaluating neurobehavioral outcomes after exposure 评估暴露后的神经行为结果
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-05-01 DOI: 10.1016/j.ntt.2025.107460
Claire Coles
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引用次数: 0
A longitudinal study comparing the impact of pesticide exposure on cognitive abilities of Latinx children from rural farmworker and urban non-farmworker families 一项比较农药暴露对农村农场工人和城市非农场工人家庭拉丁裔儿童认知能力影响的纵向研究
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-04-13 DOI: 10.1016/j.ntt.2025.107450
Monica Soni , Haiying Chen , Milton J. Cepeda , Lesley Berenson , Sydney Smith , Kim A. Anderson , Sara A. Quandt , Thomas A. Arcury , Paul J. Laurienti , Jonathan H. Burdette
Growing evidence shows that pesticide exposure contributes to numerous adverse health effects. Pesticide exposure can be especially problematic for vulnerable populations, and even more so for children in vulnerable populations who are still developing, such as Latinx children. Several studies have demonstrated the negative cognitive effects of prenatal exposure to pesticides, particularly organophosphates (OPs). We previously reported the results from a baseline study (Dobbins et al., 2022) designed to compare the cognitive abilities of 8-year-old children from rural, farmworking families and urban, non-farmworking families. We found that the children from both populations have considerable pesticide exposure, but to different chemicals. The children of farmworkers had greater exposure to OPs, while the children of non-farmworkers had greater exposure to organochlorines (OCs) and pyrethroids. Using the Weschler Intelligence Scale for Children–Fifth Edition (WISC-V), baseline analyses determined that children of non-farmworkers exhibited lower cognitive scores, specifically on the VSI (visual spatial) and VCI (verbal comprehension) indices. The current study examined the longitudinal significance of these findings in the same participants over a 2–3-year period. We present evidence that children from non-farmworking families exhibited significant declines on the FRI (fluid reasoning index) of the WISC-V. The children from farmworker families did not decline, and this longitudinal difference between the groups was significant. Our findings further suggest that these declines in FRI scores are likely due to greater cumulative OC exposure over the entire longitudinal period.
越来越多的证据表明,接触农药会对健康造成许多不利影响。农药接触对弱势群体来说尤其成问题,对仍在发育中的弱势群体中的儿童(如拉丁裔儿童)来说更是如此。一些研究已经证明了产前暴露于农药,特别是有机磷农药(OPs)的负面认知影响。我们之前报道了一项基线研究(Dobbins et al., 2022)的结果,该研究旨在比较农村、务农家庭和城市、非务农家庭的8岁儿童的认知能力。我们发现这两个群体的孩子都有相当多的农药接触,但接触的是不同的化学物质。农场工人的孩子更容易接触到有机氯,而非农场工人的孩子更容易接触到有机氯和拟除虫菊酯。使用Weschler儿童智力量表-第五版(WISC-V),基线分析确定非农业工人的儿童表现出较低的认知得分,特别是在VSI(视觉空间)和VCI(言语理解)指数上。目前的研究对同样的参与者进行了为期2 - 3年的纵向研究。我们提供的证据表明,来自非农业家庭的儿童在WISC-V的FRI(流体推理指数)上表现出显著的下降。来自农场工人家庭的孩子没有下降,而且组间的这种纵向差异是显著的。我们的研究结果进一步表明,FRI分数的下降可能是由于整个纵向期间累积的OC暴露增加。
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引用次数: 0
An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans 三氯醇致人神经毒性机制的计算机分析
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-03-30 DOI: 10.1016/j.ntt.2025.107447
Fuat Karakuş , Burak Kuzu
Dicofol (DCF) is an organochlorine pesticide that has recently been recognized as a persistent organic pollutant. This study begins by investigating the neurotoxicity of DCF and its metabolites through in silico tools. It subsequently explores the molecular mechanisms and key targets associated with DCF-induced neurotoxicity in humans by employing network toxicology, multi-level bioinformatics approaches, and molecular docking analyses. The prediction results indicate that both DCF and its metabolites can traverse the blood-brain barrier, penetrating the central nervous system, and inducing neurotoxicity. A thorough analysis has identified 56 potential targets linked to DCF-induced neurotoxicity. Gene Ontology enrichment analysis revealed significant associations with pathways related to sodium ion transmembrane transport, sodium/potassium-exchanging ATPase complexes, and P-type calcium transporter activity. Pathway enrichment analysis suggests that DCF-induced neurotoxicity arises from disruptions in ion transport via P-type ATPases. Further examination of gene-gene and protein-protein interactions, along with centrality analysis, identified 11 hub targets, including ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, and MAPK1, as key players. Notably, six of these targets are subunits of the Na+/K+-ATPase, a P-type ATPase. Molecular docking results demonstrated that DCF binds more effectively to the ATP1A3-ATP1B1 protein complex than to its natural ligand, ATP. These findings suggest that DCF may inhibit Na+/K+-ATPase through ATP1A3, resulting in an imbalance of sodium and potassium gradients and ultimately leading to neurotoxicity.
三氯醇(DCF)是一种有机氯农药,近年来被认为是一种持久性有机污染物。本研究首先通过计算机工具研究DCF及其代谢物的神经毒性。随后,通过网络毒理学、多层次生物信息学方法和分子对接分析,探讨了dcf诱导人类神经毒性的分子机制和关键靶点。预测结果表明,DCF及其代谢物均可穿过血脑屏障,穿透中枢神经系统,引起神经毒性。一项彻底的分析已经确定了56个与dcf引起的神经毒性有关的潜在目标。基因本体富集分析显示,与钠离子跨膜转运、钠/钾交换atp酶复合物和p型钙转运蛋白活性相关的途径存在显著关联。途径富集分析表明,dcf诱导的神经毒性是由通过p型atp酶的离子运输中断引起的。进一步研究基因-基因和蛋白质-蛋白质相互作用,以及中心性分析,确定了11个枢纽靶点,包括ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2和MAPK1,是关键角色。值得注意的是,这些靶标中有6个是Na+/K+- atp酶(一种p型atp酶)的亚基。分子对接结果表明,DCF与ATP1A3-ATP1B1蛋白复合物的结合比其天然配体ATP更有效。这些发现提示DCF可能通过ATP1A3抑制Na+/K+- atp酶,导致钠钾梯度失衡,最终导致神经毒性。
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引用次数: 0
Exploring how pregnant people in recovery from opioid use disorder describe their child during pregnancy 探索从阿片类药物使用障碍中恢复的孕妇如何在怀孕期间描述他们的孩子
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-03-27 DOI: 10.1016/j.ntt.2025.107449
Katherine L. Guyon-Harris , Regan Carell , Montia D. Brock , Kathryn L. Humphreys , Alissa C. Huth-Bocks

Objective

Understanding parenting strengths and challenges among pregnant people in recovery from opioid use disorder supports effective intervention delivery. How parents think and feel about their child prenatally has implications for postnatal parenting. In our past work, greater use of positive compared to negative or neutral prenatal descriptors of the child during pregnancy was associated with higher sensitivity, warmth, and engagement during caregiver–infant interactions 12-months postpartum. We analyzed descriptions of the child among pregnant people in recovery compared to a non-substance using sample to further our understanding of potential parenting strengths and risks for people in recovery.

Method

Participants included pregnant people (N = 18; M age = 30.06, SD = 3.33) recruited from an outpatient substance use treatment program providing buprenorphine (recovery sample) and a comparison sample of pregnant people (N = 120; M age = 26.16, SD = 5.71) reporting high rates of economic disadvantage and intimate partner violence, but not substance use. Through a semi-structured interview, participants described the personality of the child they were pregnant with in up to five words/phrases. Each description was coded as positive, neutral, or negative.

Results

Participants in the recovery sample used a greater number of positive words on average (M = 3.5, SD = 1.4) relative to the comparison sample (M = 2.7, SD = 1.5; Cohen's d = 0.56, 95 % confidence interval: LL = 0.06, UL = 1.06). Use of negative descriptors was similar across samples.

Conclusions

Assessing how pregnant people in recovery think and feel about their developing fetus is feasible and could create opportunities for engagement in preventive parenting interventions to support healthy conceptualizations of the child.
目的了解阿片类药物使用障碍恢复期孕妇的育儿优势和挑战,为有效干预提供支持。父母在产前对孩子的看法和感受对产后的养育有影响。在我们过去的研究中,在怀孕期间,与消极或中性的产前描述相比,更多地使用积极的描述与产后12个月的照顾者-婴儿互动中更高的敏感性、温暖度和参与度相关。我们分析了孕妇在康复过程中对孩子的描述,并将其与非物质样本进行了比较,以进一步了解康复过程中潜在的育儿优势和风险。方法纳入孕妇(N = 18;M年龄= 30.06,SD = 3.33),从门诊药物使用治疗项目中招募,提供丁丙诺啡(恢复样本)和比较样本孕妇(N = 120;(年龄= 26.16,SD = 5.71)报告经济劣势和亲密伴侣暴力的发生率较高,但药物使用的发生率较低。通过一个半结构化的访谈,参与者用最多五个单词/短语描述他们怀孕的孩子的性格。每个描述都被编码为积极的、中性的或消极的。结果恢复组的被试平均使用的积极词汇数(M = 3.5, SD = 1.4)高于对照组(M = 2.7, SD = 1.5;Cohen’s d = 0.56, 95%置信区间:LL = 0.06, UL = 1.06)。负面描述符的使用在各个样本中是相似的。结论评估恢复期孕妇对胎儿发育的看法和感受是可行的,可以为参与预防性育儿干预创造机会,以支持孩子的健康受孕。
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引用次数: 0
Developmental impacts of deprivation and threat on emotion recognition 剥夺和威胁对情绪识别的发展影响
IF 2.6 3区 医学 Q3 NEUROSCIENCES Pub Date : 2025-03-24 DOI: 10.1016/j.ntt.2025.107446
Nicolas Murgueitio , Margaret A. Sheridan , Michelle Shipkova , Amy G. Halberstadt , Patricia T. Garrett-Peters , Cathi B. Propper
Dimensional models of early adversity propose developmental mechanisms by which threat and deprivation confer risk for psychopathology. Exposure to violent environments may influence social information processing biases, and limited access to complex learning environments might be associated with general challenges in emotion recognition. We examined associations of adversity measured early in development (6–36 months) and emotion recognition in early (72 months) and middle (96 months) childhood in a sample of 92 mother-child dyads. Low cognitive stimulation negatively predicted early childhood emotion recognition (β = −0.32, p = .01). Moreover, experiences of intimate-partner violence were associated with anger bias, but not global emotion recognition, in early (β = 0.24, p = .01), and middle (β = 0.18, p = .04) childhood. This pattern suggests that while the lack of exposure to complex learning experiences might impact children's conceptual knowledge of emotions, children who experience violence show biases that facilitate threat detection.
早期逆境的维度模型提出了威胁和剥夺赋予精神病理风险的发展机制。暴露在暴力环境中可能会影响社会信息处理偏见,而进入复杂学习环境的机会有限可能与情绪识别方面的一般挑战有关。我们以92对母子为样本,研究了在发育早期(6-36个月)和童年早期(72个月)和中期(96个月)测量的逆境与情绪识别的关联。低认知刺激负向预测幼儿情绪识别(β = - 0.32, p = 0.01)。此外,在童年早期(β = 0.24, p = 0.01)和中期(β = 0.18, p = 0.04),亲密伴侣暴力的经历与愤怒偏见有关,但与整体情绪识别无关。这一模式表明,虽然缺乏接触复杂学习经验可能会影响儿童对情绪的概念性知识,但经历过暴力的儿童表现出有助于发现威胁的偏见。
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Neurotoxicology and teratology
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