An important task in the course of pharmaceutical development of solid dosage forms is to determine a set of technological methods and study the technological parameters of the powders under research for the purpose of further encapsulation or tabletting of substances with different physicochemical characteristics. Aim. To study the main technological parameters of the standardized substance of the propolis phenolic hydrophobic drug (PPHD), grape seeds, bitter chestnut seeds and their mixtures for the purpose of their further introduction into the capsules with the anti-inflammatory and venotonic action developed. Materials and methods. The pharmaco-technological studies of AFI powder masses (fluidity, angle of repose, bulk density, etc.) were performed in accordance with the requirements of the State Pharmacopoeia of Ukraine and scientific and practical sources of literature. Results and discussion. The tests performed indicate that the substances studied and their mixtures do not have satisfactory pharmaco-technological properties, are characterized by a low value of fluidity and the ability to absorb moisture during storage. Conclusions. The results of the research conducted confirm the need to add certain groups of excipients in the powder mass for their further encapsulation and the use of appropriate technological methods when developing oral dosage forms.
{"title":"Determination of technological parameters of powder masses of the propolis phenolic hydrophobic drug, grape seeds, bitter chestnut seeds and their mixtures in solid dosage forms","authors":"A. S. Gurtovsky, O. Shpychak, S. Spyrydonov","doi":"10.24959/nphj.21.66","DOIUrl":"https://doi.org/10.24959/nphj.21.66","url":null,"abstract":"An important task in the course of pharmaceutical development of solid dosage forms is to determine a set of technological methods and study the technological parameters of the powders under research for the purpose of further encapsulation or tabletting of substances with different physicochemical characteristics.\u0000Aim. To study the main technological parameters of the standardized substance of the propolis phenolic hydrophobic drug (PPHD), grape seeds, bitter chestnut seeds and their mixtures for the purpose of their further introduction into the capsules with the anti-inflammatory and venotonic action developed.\u0000Materials and methods. The pharmaco-technological studies of AFI powder masses (fluidity, angle of repose, bulk density, etc.) were performed in accordance with the requirements of the State Pharmacopoeia of Ukraine and scientific and practical sources of literature.\u0000Results and discussion. The tests performed indicate that the substances studied and their mixtures do not have satisfactory pharmaco-technological properties, are characterized by a low value of fluidity and the ability to absorb moisture during storage.\u0000Conclusions. The results of the research conducted confirm the need to add certain groups of excipients in the powder mass for their further encapsulation and the use of appropriate technological methods when developing oral dosage forms.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72565179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The presence of different groups of biologically active substances in the medicinal plant raw material determines its wide use in medical practice. The study of the chemical composition and possible pharmacological effects of medicinal plants are priorities in the process of their research. Aim. To study the content and the composition of fatty acids in Anchusa officinalis L. herb of the Ukrainian flora using the gas chromatography/mass spectrometry method (GC/MS). Materials and methods. The samples of Anchusa officinalis L. herb were harvested in June 2017 in the Ivano-Frankivsk region. The study was performed using the GC/MS method. To identify the components, the spectra obtained were considered on the basis of general laws of fragmentation for molecules of organic compounds under the action of the electron impact, as well as by comparing the results with data from NIST05 and WILEY 2007 mass spectrum libraries. The data analysis was performed using Statistic 7.0, Excel 7.0 statistical program package for Microsoft Office for Windows. Results and discussion. This study presents the results the fatty acids investigation in Anchusa officinalis L. herb of the Ukrainian flora. For the first time, 8 fatty acids were identified. They were myristic acid (163.36 mg/kg), palmitic acid (2324.39 mg/kg), linoleic acid (1498.33 mg/kg), linolenic acid (2696.36 mg/kg), stearic acid (410.16 mg/kg), arachidic acid (240.43 mg/kg), behenic acid (409.23 mg/kg), lignoceric acid (498,38 mg/kg). The total mass of unsaturated fatty acids (linoleic and linolenic acid) was 4045.95 mg/kg, while the total mass of saturated fatty acids (myristic, palmitic, stearic, arachidic, behenic and lignoceric acid) was 4194.69 mg/kg. It indicates an insignificant predominance of unsaturated acids in the plant raw material. The total content of fatty acids in Anchusa officinalis L. herb was 8240.64 mg/kg (0.8 % by weight of the plant raw material). Conclusions. The study of fatty acids in Anchusa officinalis L. herb of the Ukrainian flora has been conducted for the first time. In the raw material, the following 8 fatty acids have been identified: unsaturated fatty acids (linoleic and linolenic acid) and saturated fatty acids (myristic, palmitic, stearic, arachidic, behenic and lignoceric acid). The total content of fatty acids in Anchusa officinalis L. herb is 0.8 % by weight of a dry raw material. The dominant compound among fatty acids is linolenic acid (2696.36 mg/kg of a dry raw material). Taking into account the above the further search for the method of obtaining the fatty acid complex from Anchusa officinalis L. herb is promising in order to develop the effective and safe herbal medicines.
{"title":"The study of fatty acids in Anchusa officinalis L. herb of the Ukrainian flora","authors":"S. Svirska","doi":"10.24959/nphj.21.61","DOIUrl":"https://doi.org/10.24959/nphj.21.61","url":null,"abstract":"The presence of different groups of biologically active substances in the medicinal plant raw material determines its wide use in medical practice. The study of the chemical composition and possible pharmacological effects of medicinal plants are priorities in the process of their research.\u0000Aim. To study the content and the composition of fatty acids in Anchusa officinalis L. herb of the Ukrainian flora using the gas chromatography/mass spectrometry method (GC/MS).\u0000Materials and methods. The samples of Anchusa officinalis L. herb were harvested in June 2017 in the Ivano-Frankivsk region. The study was performed using the GC/MS method. To identify the components, the spectra obtained were considered on the basis of general laws of fragmentation for molecules of organic compounds under the action of the electron impact, as well as by comparing the results with data from NIST05 and WILEY 2007 mass spectrum libraries. The data analysis was performed using Statistic 7.0, Excel 7.0 statistical program package for Microsoft Office for Windows.\u0000Results and discussion. This study presents the results the fatty acids investigation in Anchusa officinalis L. herb of the Ukrainian flora. For the first time, 8 fatty acids were identified. They were myristic acid (163.36 mg/kg), palmitic acid (2324.39 mg/kg), linoleic acid (1498.33 mg/kg), linolenic acid (2696.36 mg/kg), stearic acid (410.16 mg/kg), arachidic acid (240.43 mg/kg), behenic acid (409.23 mg/kg), lignoceric acid (498,38 mg/kg). The total mass of unsaturated fatty acids (linoleic and linolenic acid) was 4045.95 mg/kg, while the total mass of saturated fatty acids (myristic, palmitic, stearic, arachidic, behenic and lignoceric acid) was 4194.69 mg/kg. It indicates an insignificant predominance of unsaturated acids in the plant raw material. The total content of fatty acids in Anchusa officinalis L. herb was 8240.64 mg/kg (0.8 % by weight of the plant raw material).\u0000Conclusions. The study of fatty acids in Anchusa officinalis L. herb of the Ukrainian flora has been conducted for the first time. In the raw material, the following 8 fatty acids have been identified: unsaturated fatty acids (linoleic and linolenic acid) and saturated fatty acids (myristic, palmitic, stearic, arachidic, behenic and lignoceric acid). The total content of fatty acids in Anchusa officinalis L. herb is 0.8 % by weight of a dry raw material. The dominant compound among fatty acids is linolenic acid (2696.36 mg/kg of a dry raw material). Taking into account the above the further search for the method of obtaining the fatty acid complex from Anchusa officinalis L. herb is promising in order to develop the effective and safe herbal medicines.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87846922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mishchenko, S. Shtrygol’, A. Lozynskyi, R. Lesyk
Aim. To study the range of psychotropic properties of a new original compound of 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4 thiazolidinone with the anticonvulsant activity. Materials and methods. Adult nonlinear white mice of both sexes weighing 20-27 g were used in the experiments. The locomotor, exploratory, emotional activities were studied in the open field test. The elevated plus maze was used to study anxiety. The effect of the compound on depressive behavior was studied by the tail suspension test. The passive avoidance test was used to study memory. The influence of the compound on the skeletal muscle tone and coordination was studied in the rotarod test. Actoprotective properties were studied in a swimming test with a load of 10 % by weight of the animal. Results and discussion. In the previous studies, 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone showed a pronounced anticonvulsant effect in seizure models with different pathogenesis. In this study the related psychotropic effects of the test compound were studied. It was found that in intact mice 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone in the dose of 100 mg/kg by intragastrical administration did not affect the locomotor, exploratory, emotional activity and its vegetative support, anxiety, depressive activity (in contrast to the reference drug – a classic anticonvulsant sodium valproate, which showed depressive properties), and memory. The test compound did not have a negative effect on the skeletal muscle tone and coordination, but statistically significantly increased the physical endurance of animals, being only slightly inferior to the classic CNS stimulant caffeine. Conclusions. Thus, 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone in the dose of 100 mg/kg can be considered as a potential anticonvulsant without related psychotropic effects and with actoprotective properties.
{"title":"Psychotropic properties of a potential anticonvulsant of 5-[(Z)-(4-nitrobenzylidene)]-2- (thiazol-2-ylimino)-4-thiazolidinone","authors":"M. Mishchenko, S. Shtrygol’, A. Lozynskyi, R. Lesyk","doi":"10.24959/nphj.21.53","DOIUrl":"https://doi.org/10.24959/nphj.21.53","url":null,"abstract":"Aim. To study the range of psychotropic properties of a new original compound of 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4 thiazolidinone with the anticonvulsant activity.\u0000Materials and methods. Adult nonlinear white mice of both sexes weighing 20-27 g were used in the experiments. The locomotor, exploratory, emotional activities were studied in the open field test. The elevated plus maze was used to study anxiety. The effect of the compound on depressive behavior was studied by the tail suspension test. The passive avoidance test was used to study memory. The influence of the compound on the skeletal muscle tone and coordination was studied in the rotarod test. Actoprotective properties were studied in a swimming test with a load of 10 % by weight of the animal.\u0000Results and discussion. In the previous studies, 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone showed a pronounced anticonvulsant effect in seizure models with different pathogenesis. In this study the related psychotropic effects of the test compound were studied. It was found that in intact mice 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone in the dose of 100 mg/kg by intragastrical administration did not affect the locomotor, exploratory, emotional activity and its vegetative support, anxiety, depressive activity (in contrast to the reference drug – a classic anticonvulsant sodium valproate, which showed depressive properties), and memory. The test compound did not have a negative effect on the skeletal muscle tone and coordination, but statistically significantly increased the physical endurance of animals, being only slightly inferior to the classic CNS stimulant caffeine.\u0000Conclusions. Thus, 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone in the dose of 100 mg/kg can be considered as a potential anticonvulsant without related psychotropic effects and with actoprotective properties.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79826325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Ivanov, O. Р. Bezugla, O. Shcherbak, L. Derymedvid, V. Kravchenko
Aim. To analyze data on combined drugs in soft dosage forms as potential drug interfaces. Materials and methods. The bibliosemantic research method was used in the work. Results and discussion. By analogy with foreign interfaces of carbon nanotubes with neurons it has been proposed to consider a number of soft dosage forms as interfaces between inanimate organic structures of dosage forms and living cells of the skin tissue or the mucous membrane. A number of soft dosage forms, which can be considered as interfaces between the inanimate organics of dosage forms and living cells of the skin tissue and mucosa, has been studied and analyzed. Interfaces are polymer matrices made of polyethylene glycols, high molecular weight polysaccharides, carbomers, etc. A carbomer can be considered as the basis of plastic, conformationally mobile interfaces between the general dosage form and living cells of the skin and mucosa. It has been shown that the mechanism of increasing biocompatibility with the help of polyethylene glycols is the ability of PEG molecules due to compaction (spiralization) or expansion of the molecules to accept the optimal conformation, giving their hydrophobic or polar groups for the optimal binding, on the one hand, with medicinal substances (drugs), and, on the other hand, with bioobjects. It has been shown that the affinity for PEG-400 phosphatidylcholine liposomes is 6 times greater than that of propylene glycol, and the affinity for PEG-1500 liposomes is 24 times higher than that of propylene glycol. Upon contact with the skin or the mucosa the interface structure may be destroyed as the components of the dosage form have different affinities for membranes of cells of biological surfaces – surface active substances that quickly bind to the lipid bilayer of the membranes of the skin or mucous membranes are the first ones that leave the dosage forms. Then, other auxiliary substances of the interface bind to the cell membranes at different speeds and in different ways. Conclusions. Therefore, a dosage form as an interface is a dynamic matrix that can rebuild and, as it contacts the membranes of skin cells or mucous membranes, promote absorption of the drug substance according to a specific program.
{"title":"Soft dosage forms as interfaces","authors":"L. Ivanov, O. Р. Bezugla, O. Shcherbak, L. Derymedvid, V. Kravchenko","doi":"10.24959/nphj.21.57","DOIUrl":"https://doi.org/10.24959/nphj.21.57","url":null,"abstract":"Aim. To analyze data on combined drugs in soft dosage forms as potential drug interfaces.\u0000Materials and methods. The bibliosemantic research method was used in the work.\u0000Results and discussion. By analogy with foreign interfaces of carbon nanotubes with neurons it has been proposed to consider a number of soft dosage forms as interfaces between inanimate organic structures of dosage forms and living cells of the skin tissue or the mucous membrane. A number of soft dosage forms, which can be considered as interfaces between the inanimate organics of dosage forms and living cells of the skin tissue and mucosa, has been studied and analyzed. Interfaces are polymer matrices made of polyethylene glycols, high molecular weight polysaccharides, carbomers, etc. A carbomer can be considered as the basis of plastic, conformationally mobile interfaces between the general dosage form and living cells of the skin and mucosa. It has been shown that the mechanism of increasing biocompatibility with the help of polyethylene glycols is the ability of PEG molecules due to compaction (spiralization) or expansion of the molecules to accept the optimal conformation, giving their hydrophobic or polar groups for the optimal binding, on the one hand, with medicinal substances (drugs), and, on the other hand, with bioobjects. It has been shown that the affinity for PEG-400 phosphatidylcholine liposomes is 6 times greater than that of propylene glycol, and the affinity for PEG-1500 liposomes is 24 times higher than that of propylene glycol. Upon contact with the skin or the mucosa the interface structure may be destroyed as the components of the dosage form have different affinities for membranes of cells of biological surfaces – surface active substances that quickly bind to the lipid bilayer of the membranes of the skin or mucous membranes are the first ones that leave the dosage forms. Then, other auxiliary substances of the interface bind to the cell membranes at different speeds and in different ways.\u0000Conclusions. Therefore, a dosage form as an interface is a dynamic matrix that can rebuild and, as it contacts the membranes of skin cells or mucous membranes, promote absorption of the drug substance according to a specific program.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89128297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kobets, Yuri Kobets, N. Malinina, O. Filiptsova, O. Ibrahimova
Every pharmacy manager is faced with the question of motivating his/her employees. Unfortunately, there are no single motivational schemes that would effectively affect all pharmacists in the same manner. Aim. To study the current attitude of specialists to the system of the staff motivation in a pharmacy. Materials and methods. The field studies were used in the work. A survey of pharmacists and pharmaceutists of one of the pharmacy chain in Kharkiv was carried out. 107 specialists were interviewed. The database obtained as a result of the questionnaire was formed in Microsoft Excel. All calculations were performed in Microsoft Excel. Results and discussion. A survey of pharmacists and pharmaceutists of pharmacies of one of the pharmacy network in Kharkiv was carried out. The information obtained as a result of the questionnaire was collected in accordance with ethical requirements. The relationship between qualitative characteristics was carried out using the χ2 test. The current attitude of specialists to the system of motivation in a pharmacy was studied. It was revealed that the employee’s motivation depended by 70 % on how the manager worked on this problem. As a result of the study, it was found that 46 % of the surveyed specialists went to work with a sense of habit and only 16 % with a sense of a creative impulse. The question of changing the place of work was investigated. It was determined that 34 % of respondents wanted to change their place of work, 28 % of respondents were completely satisfied with their position. Although a significant percentage of the surveyed specialists are now thinking about changing jobs, the COVID-19 pandemic has made its own adjustments. Most workers remain at their jobs for now, fearing that they will lose their jobs altogether. Motivating and demotivating factors for pharmacy workers were determined. Among the motivating factors, one can single out the loyal attitude of the management, a friendly team, the presence of social guarantees (the right to work, the right to rest, retirement benefits). Demotivating factors are the lack of career prospects, inadequate working conditions, the lack of innovation, insufficient technological support. Conclusions. As a result of the study of the motivational environment of one of the network of pharmacies in Kharkiv, it has been found that the mechanisms used do not sufficiently ensure the achievement of the goals of this network of pharmacies. For optimal motivation, it is necessary to apply the elements of the motivation system in a comprehensive manner.
{"title":"The study of the current attitude of specialists to the system of the staff motivation in a pharmacy","authors":"M. Kobets, Yuri Kobets, N. Malinina, O. Filiptsova, O. Ibrahimova","doi":"10.24959/nphj.21.70","DOIUrl":"https://doi.org/10.24959/nphj.21.70","url":null,"abstract":"Every pharmacy manager is faced with the question of motivating his/her employees. Unfortunately, there are no single motivational schemes that would effectively affect all pharmacists in the same manner.\u0000Aim. To study the current attitude of specialists to the system of the staff motivation in a pharmacy.\u0000Materials and methods. The field studies were used in the work. A survey of pharmacists and pharmaceutists of one of the pharmacy chain in Kharkiv was carried out. 107 specialists were interviewed. The database obtained as a result of the questionnaire was formed in Microsoft Excel. All calculations were performed in Microsoft Excel.\u0000Results and discussion. A survey of pharmacists and pharmaceutists of pharmacies of one of the pharmacy network in Kharkiv was carried out. The information obtained as a result of the questionnaire was collected in accordance with ethical requirements. The relationship between qualitative characteristics was carried out using the χ2 test. The current attitude of specialists to the system of motivation in a pharmacy was studied. It was revealed that the employee’s motivation depended by 70 % on how the manager worked on this problem. As a result of the study, it was found that 46 % of the surveyed specialists went to work with a sense of habit and only 16 % with a sense of a creative impulse. The question of changing the place of work was investigated. It was determined that 34 % of respondents wanted to change their place of work, 28 % of respondents were completely satisfied with their position. Although a significant percentage of the surveyed specialists are now thinking about changing jobs, the COVID-19 pandemic has made its own adjustments. Most workers remain at their jobs for now, fearing that they will lose their jobs altogether. Motivating and demotivating factors for pharmacy workers were determined. Among the motivating factors, one can single out the loyal attitude of the management, a friendly team, the presence of social guarantees (the right to work, the right to rest, retirement benefits). Demotivating factors are the lack of career prospects, inadequate working conditions, the lack of innovation, insufficient technological support.\u0000Conclusions. As a result of the study of the motivational environment of one of the network of pharmacies in Kharkiv, it has been found that the mechanisms used do not sufficiently ensure the achievement of the goals of this network of pharmacies. For optimal motivation, it is necessary to apply the elements of the motivation system in a comprehensive manner.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84274457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim. To determine the elemental composition of common domestic types of the medicinal plant raw material, such as Sophora japonica flower buds, Crataegus sanguinea leaves and flowers, Astragalus dasyanthus herb, Mentha piperita leaves, Arctium lappa roots. Materials and methods. The elemental composition was studied by atomic absorption spectrography with photographic registration. The research was conducted at the premises of STC “Institute of Single Crystals” of the National Academy of Sciences of Ukraine (Kharkiv). Results and discussion. The results of the research obtained show that the samples of common domestic types of the medicinal plant raw material studied contain at least 19 chemical elements; potassium, calcium, magnesium, and phosphorus predominate among them. Conclusions. The study shows the prospects of creating new original complex drugs from the raw material of the plants studied for the prevention and treatment of diseases of the cardiovascular system, in particular hypertension.
{"title":"The study of the elemental composition of common domestic types of the medicinal plant raw material","authors":"Y. Zudova, O. Khvorost","doi":"10.24959/nphj.21.68","DOIUrl":"https://doi.org/10.24959/nphj.21.68","url":null,"abstract":"Aim. To determine the elemental composition of common domestic types of the medicinal plant raw material, such as Sophora japonica flower buds, Crataegus sanguinea leaves and flowers, Astragalus dasyanthus herb, Mentha piperita leaves, Arctium lappa roots.\u0000Materials and methods. The elemental composition was studied by atomic absorption spectrography with photographic registration. The research was conducted at the premises of STC “Institute of Single Crystals” of the National Academy of Sciences of Ukraine (Kharkiv).\u0000Results and discussion. The results of the research obtained show that the samples of common domestic types of the medicinal plant raw material studied contain at least 19 chemical elements; potassium, calcium, magnesium, and phosphorus predominate among them.\u0000Conclusions. The study shows the prospects of creating new original complex drugs from the raw material of the plants studied for the prevention and treatment of diseases of the cardiovascular system, in particular hypertension.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"386 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75543809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim. To conduct the cluster analysis of the results of an expert survey for the development of priority directions of informatization of logistics processes in the medical supply system of the Armed Forces of Ukraine. Materials and methods. To achieve the goal of the study, the analysis of foreign and domestic scientific sources and the current legal documents was conducted. The methods of information retrieval, systematization, content analysis and the technology of hierarchical agglomeration cluster analysis were used. Results and discussion. By clustering the results of an expert survey on informatization of logistic processes in the medical supply system of the Armed Forces of Ukraine the distribution into seven clusters formed due to similar answers to the questionnaire was obtained. The number of clusters was determined by the dendrogram construction program without any researcher’s assumptions. The cluster analysis showed stable cluster groupings with a certain level of tightness of relations between features both within a cluster and among several clusters. This corresponds to the vision of the experts who outlined the problem on the research topic and determine the ways to solve it. Conclusions. Based on the results of the analysis of the personal composition of each cluster, a sufficiently high level of consistency of the conclusions of experts of the medical supply system of the Armed Forces of Ukraine to the need for the introduction of informatization of logistics processes has been determined. Priority directions of informatization of logistic processes in the medical supply system of the Armed Forces of Ukraine have been developed; a decisive place in these directions belongs to the implementation of a program for automatic accounting of medical supplies in the Armed Forces of Ukraine. The need for the introduction of modern software for decision-making support in the management of flow processes of providing medical supplies and equipment of the Armed Forces of Ukraine, as well as information analytical tools for the needs of the Medical Supply Directorate of the Medical Forces Command of the Armed Forces of Ukraine has been substantiated.
{"title":"The cluster analysis in the development of priority directions of informatization of logistics processes in the medical supply system of the Armed Forces of Ukraine","authors":"M. Bilous","doi":"10.24959/nphj.21.69","DOIUrl":"https://doi.org/10.24959/nphj.21.69","url":null,"abstract":"Aim. To conduct the cluster analysis of the results of an expert survey for the development of priority directions of informatization of logistics processes in the medical supply system of the Armed Forces of Ukraine.\u0000Materials and methods. To achieve the goal of the study, the analysis of foreign and domestic scientific sources and the current legal documents was conducted. The methods of information retrieval, systematization, content analysis and the technology of hierarchical agglomeration cluster analysis were used.\u0000Results and discussion. By clustering the results of an expert survey on informatization of logistic processes in the medical supply system of the Armed Forces of Ukraine the distribution into seven clusters formed due to similar answers to the questionnaire was obtained. The number of clusters was determined by the dendrogram construction program without any researcher’s assumptions. The cluster analysis showed stable cluster groupings with a certain level of tightness of relations between features both within a cluster and among several clusters. This corresponds to the vision of the experts who outlined the problem on the research topic and determine the ways to solve it.\u0000Conclusions. Based on the results of the analysis of the personal composition of each cluster, a sufficiently high level of consistency of the conclusions of experts of the medical supply system of the Armed Forces of Ukraine to the need for the introduction of informatization of logistics processes has been determined. Priority directions of informatization of logistic processes in the medical supply system of the Armed Forces of Ukraine have been developed; a decisive place in these directions belongs to the implementation of a program for automatic accounting of medical supplies in the Armed Forces of Ukraine. The need for the introduction of modern software for decision-making support in the management of flow processes of providing medical supplies and equipment of the Armed Forces of Ukraine, as well as information analytical tools for the needs of the Medical Supply Directorate of the Medical Forces Command of the Armed Forces of Ukraine has been substantiated.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73252516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Kazakova, S. Kovalenko, V. Lebedynets, V. Kazakova
Aim. To develop conceptual approaches for regulating the turnover of cosmetic products in Ukraine. Materials and methods. As research materials the processes of technical regulation of cosmetic products were studied; logical, research methods, as well as the method of content analysis were used. Results and discussion. The state of technical regulation of the turnover of cosmetic products in a number of foreign countries has been studied. The analysis of the implementation of the specifications on cosmetic products has been performed, and the potential risks during its implementation in Ukraine have been determined. The model of the implementation plan of the normative legal act and the procedure of application of its basic provisions has been developed. Conclusions. Based on the analysis of the issues of technical regulation of cosmetic products the methodology for implementing the normative legal act, which regulates the rules of the product turnover at the Ukrainian market, has been proposed.
{"title":"Development of conceptual approaches for regulating the turnover of cosmetic products in Ukraine","authors":"I. Kazakova, S. Kovalenko, V. Lebedynets, V. Kazakova","doi":"10.24959/nphj.21.63","DOIUrl":"https://doi.org/10.24959/nphj.21.63","url":null,"abstract":"Aim. To develop conceptual approaches for regulating the turnover of cosmetic products in Ukraine.\u0000Materials and methods. As research materials the processes of technical regulation of cosmetic products were studied; logical, research methods, as well as the method of content analysis were used.\u0000Results and discussion. The state of technical regulation of the turnover of cosmetic products in a number of foreign countries has been studied. The analysis of the implementation of the specifications on cosmetic products has been performed, and the potential risks during its implementation in Ukraine have been determined. The model of the implementation plan of the normative legal act and the procedure of application of its basic provisions has been developed.\u0000Conclusions. Based on the analysis of the issues of technical regulation of cosmetic products the methodology for implementing the normative legal act, which regulates the rules of the product turnover at the Ukrainian market, has been proposed.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85385265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim. To determine the potential risk factors associated with the critical quality indicators of the combined medicine “Neuronucleos” in the capsule dosage form for the treatment of polyneuropathies using the general risk assessment methodology while planning the drug quality at the stage of pharmaceutical development (PD). Materials and methods. The series of the combined medicine “Neuronucleos” in the capsule dosage form, critical indicators of the drug quality, the flowchart of the drug production, critical control points of the drug manufacturing process were developed. The method of causality was used. The quantitative assessment of risk factors was carriedout using the FMECA methodology. Results and discussion. The main objective of this study was to apply the Quality-by-Design (QbD) approach to PD of the combined medicine in the capsule dosage form based on uridine-5 monophosphate disodium salt (UMP), cytidine-5-monophosphate disodium salt (CMF), vitamin B6, thioctic acid and magnesium lactate dihydrate. For better patient compliance and the product quality, a target quality profile as a base for PD planning, as well as critical quality attributes (CQA) related to the product safety and efficacy were determined. The criticality of each CQA was assessed using a special scale. It was shown that “Quantitative content”, “Uniformity of dosage units”, “Dissolution”, “Impurities” were defined as the most CQA due to the minimum amount of UMF and CMF in the capsule and the possibility of their decomposition and increase in the quantity of impurities. The critical attributes of materials (CMA) were identified, and the characteristics required to control them were determined in order to ensure the expected product quality. The primary assessment of the quality indicator risks of the active ingredients was performed. It was found that the particle size affected the homogeneity, the quantitative content of API and dissolution in FPP, and it was shown that the solubility of active substances had a high risk when performing the “Dissolution” test. To determine the potential factors with a significant impact on the drug quality the maximum number of factors was found, and the Ishikawa diagram was constructed. The risk factors associated with the quality and compatibility of active substances and excipients, the quality of primary packaging, production conditions, the drug quality control and the technological process were identified. These factors are the causes of risk and can lead to a situation with negative consequences for the quality of a medicinal product. The FMECA process assessment allowed us to determine the impact of the manufacturing process on the CQA. Conclusions. At the stage of PD for the combined medicine in the capsule dosage form the potential critical indicators of the drug quality have been determined. The critical parameters of the quality of the initial components and the properties of the product have been assessed; the most probab
{"title":"The risk assessment of the combined medicine in the capsule dosage form at the pharmaceutical development stage","authors":"M. Almakaiev, O. Bashura, L. Sidenko","doi":"10.24959/nphj.21.54","DOIUrl":"https://doi.org/10.24959/nphj.21.54","url":null,"abstract":"Aim. To determine the potential risk factors associated with the critical quality indicators of the combined medicine “Neuronucleos” in the capsule dosage form for the treatment of polyneuropathies using the general risk assessment methodology while planning the drug quality at the stage of pharmaceutical development (PD).\u0000Materials and methods. The series of the combined medicine “Neuronucleos” in the capsule dosage form, critical indicators of the drug quality, the flowchart of the drug production, critical control points of the drug manufacturing process were developed. The method of causality was used. The quantitative assessment of risk factors was carriedout using the FMECA methodology.\u0000Results and discussion. The main objective of this study was to apply the Quality-by-Design (QbD) approach to PD of the combined medicine in the capsule dosage form based on uridine-5 monophosphate disodium salt (UMP), cytidine-5-monophosphate disodium salt (CMF), vitamin B6, thioctic acid and magnesium lactate dihydrate. For better patient compliance and the product quality, a target quality profile as a base for PD planning, as well as critical quality attributes (CQA) related to the product safety and efficacy were determined. The criticality of each CQA was assessed using a special scale. It was shown that “Quantitative content”, “Uniformity of dosage units”, “Dissolution”, “Impurities” were defined as the most CQA due to the minimum amount of UMF and CMF in the capsule and the possibility of their decomposition and increase in the quantity of impurities. The critical attributes of materials (CMA) were identified, and the characteristics required to control them were determined in order to ensure the expected product quality. The primary assessment of the quality indicator risks of the active ingredients was performed. It was found that the particle size affected the homogeneity, the quantitative content of API and dissolution in FPP, and it was shown that the solubility of active substances had a high risk when performing the “Dissolution” test. To determine the potential factors with a significant impact on the drug quality the maximum number of factors was found, and the Ishikawa diagram was constructed. The risk factors associated with the quality and compatibility of active substances and excipients, the quality of primary packaging, production conditions, the drug quality control and the technological process were identified. These factors are the causes of risk and can lead to a situation with negative consequences for the quality of a medicinal product. The FMECA process assessment allowed us to determine the impact of the manufacturing process on the CQA.\u0000Conclusions. At the stage of PD for the combined medicine in the capsule dosage form the potential critical indicators of the drug quality have been determined. The critical parameters of the quality of the initial components and the properties of the product have been assessed; the most probab","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"415 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84901012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Fedotova, H. Panfilova, O. Tsurikova, O. M. Blazhiievska
Against the background of systematic aging of the population and increase in life expectancy the problems of the spread of all forms of dementia, including Alzheimer’s disease, are becoming increasingly important. Аim. To study epidemiology of dementia and Alzheimer’s disease in Ukraine. Materials and methods. Data from the Center for Mental Health and Monitoring of Drugs and Alcohol of the Ministry of Health of Ukraine for 2015-2019 were studied. In the research, in addition to general theoretical methods, methods of epidemiological studies were also used. Results and discussion. It has been found that since 2018 in Ukraine, the incidence rates of all mental disorders (4.0 %) increased, including organic lesions with symptomatic manifestations of cognitive impairment (2.0 %), all forms of dementia (6.0 %), vascular dementia and Alzheimer’s disease (9.0 % each). The structure of dementia is dominated by vascular forms of dementia (62.59 %), while Alzheimer’s disease has been characterized since 2015 by a systematic increase in the proportion (%) from 7.0 % to 12.0 %. The average prevalence of dementia in Ukraine is 99.72, and Alzheimer’s disease is 5.34 per 100 thousand population. A significant fluctuation in the prevalence of dementia and Alzheimer’s disease in different regions of the country has been proven. Thus, in the regions of the country, these indicators differed by 6 or more times. The highest prevalence rates of dementia were observed in 7 regions (Vinnytsia, Donetsk, Zaporizhia, Zhytomyr, Kharkiv, Cherkasy and Chernihiv regions) and Kyiv, and for Alzheimer’s disease – in 3 regions (Zaporizhia, Kherson, Chernihiv) and Kyiv. Conclusions. It is necessary to introduce an effective system for recording and monitoring cases of all forms of dementia, including Alzheimer’s disease. This will form the basis for the development of models for the rational distribution of healthcare resources for the effective treatment and social rehabilitation of these groups of patients in Ukraine.
{"title":"The study of epidemiology of dementia and Alzgeimer’s disease in Ukraine","authors":"M. Fedotova, H. Panfilova, O. Tsurikova, O. M. Blazhiievska","doi":"10.24959/nphj.21.58","DOIUrl":"https://doi.org/10.24959/nphj.21.58","url":null,"abstract":"Against the background of systematic aging of the population and increase in life expectancy the problems of the spread of all forms of dementia, including Alzheimer’s disease, are becoming increasingly important.\u0000Аim. To study epidemiology of dementia and Alzheimer’s disease in Ukraine.\u0000Materials and methods. Data from the Center for Mental Health and Monitoring of Drugs and Alcohol of the Ministry of Health of Ukraine for 2015-2019 were studied. In the research, in addition to general theoretical methods, methods of epidemiological studies were also used.\u0000Results and discussion. It has been found that since 2018 in Ukraine, the incidence rates of all mental disorders (4.0 %) increased, including organic lesions with symptomatic manifestations of cognitive impairment (2.0 %), all forms of dementia (6.0 %), vascular dementia and Alzheimer’s disease (9.0 % each). The structure of dementia is dominated by vascular forms of dementia (62.59 %), while Alzheimer’s disease has been characterized since 2015 by a systematic increase in the proportion (%) from 7.0 % to 12.0 %. The average prevalence of dementia in Ukraine is 99.72, and Alzheimer’s disease is 5.34 per 100 thousand population. A significant fluctuation in the prevalence of dementia and Alzheimer’s disease in different regions of the country has been proven. Thus, in the regions of the country, these indicators differed by 6 or more times. The highest prevalence rates of dementia were observed in 7 regions (Vinnytsia, Donetsk, Zaporizhia, Zhytomyr, Kharkiv, Cherkasy and Chernihiv regions) and Kyiv, and for Alzheimer’s disease – in 3 regions (Zaporizhia, Kherson, Chernihiv) and Kyiv.\u0000Conclusions. It is necessary to introduce an effective system for recording and monitoring cases of all forms of dementia, including Alzheimer’s disease. This will form the basis for the development of models for the rational distribution of healthcare resources for the effective treatment and social rehabilitation of these groups of patients in Ukraine.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75733303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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