Pub Date : 2020-07-15DOI: 10.2530/jslsm.jslsm-41_0021
Yusuke Morimoto
Since the late 1900s, the pain-relieving effect of semiconductor lasers has been applied to the treatment of sports injuries. The treatment effect of Low reactive level laser therapy for sports disorders has been confirmed through the development of the irradiation method. This continuing development may help answer questions that still remain in the field of meniscal treatment, and may lead to new and unique treatment methods in the future. In this paper, we describe our approach to laser therapy in the prevention of sports disorders and the improvement of athletic ability, much of which is now widely applied in the field of sports medicine.
{"title":"The State of Laser Therapy in the Field of Sports Medicine and its Continuing Development","authors":"Yusuke Morimoto","doi":"10.2530/jslsm.jslsm-41_0021","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-41_0021","url":null,"abstract":"Since the late 1900s, the pain-relieving effect of semiconductor lasers has been applied to the treatment of sports injuries. The treatment effect of Low reactive level laser therapy for sports disorders has been confirmed through the development of the irradiation method. This continuing development may help answer questions that still remain in the field of meniscal treatment, and may lead to new and unique treatment methods in the future. In this paper, we describe our approach to laser therapy in the prevention of sports disorders and the improvement of athletic ability, much of which is now widely applied in the field of sports medicine.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"45 1","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80667944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-15DOI: 10.2530/jslsm.jslsm-41_0017
J. Kubota
{"title":"Bridging Laser Medicine and Sports Medical Science: History of the Laser Medicine & Sports Science","authors":"J. Kubota","doi":"10.2530/jslsm.jslsm-41_0017","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-41_0017","url":null,"abstract":"","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76377895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-15DOI: 10.2530/jslsm.jslsm-41_0014
N. Miyoshi, S. Kaneko, R. Kitai, K. Tsutsumi, Y. Sakurai, Sachiko Asayama-Kosaka, Keiji Inoue, Shigetoshi Okada
Quantitative data of the fluorescence intensity accumulated in clinical malignant brain tumor tissues (astrocytoma) were obtained from a good number of photodynamic diagnosis (PDD)-operated samples in this study. From where, it has been resulted that the concentration/intensity increases exponentially with the increase in the grades of the astrocytoma. It was found that the ratio values (I635nm/I500nm) of the fluorescence intensity against the green autofluorescence one follows the similar exponential increment for the more sensitive cancer grades with the changes on fluorescence intensity. Finally, it reflected that the ratio values could be very much helpful to estimate the Pp-IX concentration from the obtained calibration curve, as a follow through it could be a very important tool to estimate the dose of photodynamic therapy (PDT) and thereby the treatment efficiency of cancer, especially for the cases where different fluorescence concentration is estimated due to different cancer grades in a single tissue. Thus, this technique can be added as a measure of new dose calculation similar to that of the boron neutron capture therapy (BNCT), which is a new presentation for the clinical laser PDT guideline. It was also elucidated that the fluoresced metabolized material was a precursor of Hem namely, protoporphyrin-IX (Pp-IX), because the measurement by a mass spectroscopic analysis and then the comparison of the microscopic image of the mass spectroscopy with the fluorescent one matched completely through overlapping of both images.
本研究从大量的光动力诊断(PDD)手术样本中获得了临床恶性脑肿瘤组织(星形细胞瘤)积累的荧光强度的定量数据。由此可见，浓度/强度随星形细胞瘤分级的增加呈指数增长。荧光强度与绿色自身荧光强度之比(I635nm/I500nm)随着荧光强度的变化，越敏感的癌级呈类似的指数增长。最后，它反映出比值值可以非常有助于从得到的校准曲线估计Pp-IX浓度，作为后续，它可以是一个非常重要的工具来估计光动力治疗(PDT)的剂量，从而估计癌症的治疗效率，特别是在单个组织中由于不同的癌症等级而估计不同的荧光浓度的情况下。因此，该技术可以作为一种类似于硼中子捕获治疗(BNCT)的新剂量计算措施，这是临床激光PDT指南的新介绍。通过质谱分析测定，再将质谱显微镜图像与荧光显微镜图像进行重叠比较，两者完全吻合，从而证实了荧光代谢物质是Hem的前体，即原卟啉- ix (Pp-IX)。
{"title":"Application for Clinical Guideline Assessment by Fluorescent Measurements of Sensitizer Molecule in Tumor","authors":"N. Miyoshi, S. Kaneko, R. Kitai, K. Tsutsumi, Y. Sakurai, Sachiko Asayama-Kosaka, Keiji Inoue, Shigetoshi Okada","doi":"10.2530/jslsm.jslsm-41_0014","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-41_0014","url":null,"abstract":"Quantitative data of the fluorescence intensity accumulated in clinical malignant brain tumor tissues (astrocytoma) were obtained from a good number of photodynamic diagnosis (PDD)-operated samples in this study. From where, it has been resulted that the concentration/intensity increases exponentially with the increase in the grades of the astrocytoma. It was found that the ratio values (I635nm/I500nm) of the fluorescence intensity against the green autofluorescence one follows the similar exponential increment for the more sensitive cancer grades with the changes on fluorescence intensity. Finally, it reflected that the ratio values could be very much helpful to estimate the Pp-IX concentration from the obtained calibration curve, as a follow through it could be a very important tool to estimate the dose of photodynamic therapy (PDT) and thereby the treatment efficiency of cancer, especially for the cases where different fluorescence concentration is estimated due to different cancer grades in a single tissue. Thus, this technique can be added as a measure of new dose calculation similar to that of the boron neutron capture therapy (BNCT), which is a new presentation for the clinical laser PDT guideline. It was also elucidated that the fluoresced metabolized material was a precursor of Hem namely, protoporphyrin-IX (Pp-IX), because the measurement by a mass spectroscopic analysis and then the comparison of the microscopic image of the mass spectroscopy with the fluorescent one matched completely through overlapping of both images.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"95 1","pages":"110-118"},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88955750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-15DOI: 10.2530/jslsm.jslsm-40_0047
A. Hongo
Optical hollow fibers with inner dielectric and metal thin layers can deliver efficiently IR laser light which conventional silica fibers cannot be used for. A new novel endoscopic system using CO2 laser is being developed, in which such hollow fibers are considered as key devices. Compared to many other kinds of solid-core IR fibers, the hollow fibers have some advantages from the viewpoint of physical and chemical features as well as optical properties. CO2 laser light and visible aiming light transmitted through the hollow fiber are irradiated to tissues with a noncontact condition, in which the irradiating point can be grasped precisely. Unlike Nd:YAG lasers for endoscopic therapy as laser scalpels which were once widely evaluated, the light of CO2 laser does not penetrate deeply into the normal tissue and has an outstanding effect for cutting out appropriately a treatment area. The laser endoscopic system composed of the CO2 laser source and the hollow fiber is promising for a safer new method, especially a minimally invasive treatment for early stage of gastrointestinal cancers.
{"title":"Optical Hollow Fiber for CO2 Laser Light Transmission Used in Endoscopic Therapy","authors":"A. Hongo","doi":"10.2530/jslsm.jslsm-40_0047","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0047","url":null,"abstract":"Optical hollow fibers with inner dielectric and metal thin layers can deliver efficiently IR laser light which conventional silica fibers cannot be used for. A new novel endoscopic system using CO2 laser is being developed, in which such hollow fibers are considered as key devices. Compared to many other kinds of solid-core IR fibers, the hollow fibers have some advantages from the viewpoint of physical and chemical features as well as optical properties. CO2 laser light and visible aiming light transmitted through the hollow fiber are irradiated to tissues with a noncontact condition, in which the irradiating point can be grasped precisely. Unlike Nd:YAG lasers for endoscopic therapy as laser scalpels which were once widely evaluated, the light of CO2 laser does not penetrate deeply into the normal tissue and has an outstanding effect for cutting out appropriately a treatment area. The laser endoscopic system composed of the CO2 laser source and the hollow fiber is promising for a safer new method, especially a minimally invasive treatment for early stage of gastrointestinal cancers.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"33 1","pages":"2-8"},"PeriodicalIF":0.0,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85465967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-15DOI: 10.2530/jslsm.jslsm-41_0003
E. Ogawa, T. Arai, J. Usuda, K. Ohtani, S. Maehara, K. Imai, Y. Kudo, Shotaro Ono, N. Ikeda
We are developing a diffused light irradiation probe using a small diameter flexible plastic optical fiber and aiming at a photodynamic therapy in a narrow area by uniform light irradiation. In a narrow area, a direct transmission light irradiation probe could not manipulate the irradiation area, and a diffused light irradiation probe is required. The conventional diffused light irradiation probe made of quartz, has a hard tip, and could not be inserted into a curved path. We developed a light diffuser made by a small diameter plastic optical fiber and completed a small diameter and flexible diffused light irradiation probe.
{"title":"Photodynamic Treatment Using a Small Diameter Diffused Light Irradiation Probe Made of Plastic Optical Fiber","authors":"E. Ogawa, T. Arai, J. Usuda, K. Ohtani, S. Maehara, K. Imai, Y. Kudo, Shotaro Ono, N. Ikeda","doi":"10.2530/jslsm.jslsm-41_0003","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-41_0003","url":null,"abstract":"We are developing a diffused light irradiation probe using a small diameter flexible plastic optical fiber and aiming at a photodynamic therapy in a narrow area by uniform light irradiation. In a narrow area, a direct transmission light irradiation probe could not manipulate the irradiation area, and a diffused light irradiation probe is required. The conventional diffused light irradiation probe made of quartz, has a hard tip, and could not be inserted into a curved path. We developed a light diffuser made by a small diameter plastic optical fiber and completed a small diameter and flexible diffused light irradiation probe.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81749999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-15DOI: 10.2530/jslsm.jslsm-40_0053
M. Sato, Kai Eto, Junpei Masuta, Kenji Inoue, R. Kurotani, Hiroyuki Abe, I. Nishidate
We demonstrate full-field optical coherence microscopy (FF-OCM) using an ultrathin forward-imaging short multimode fiber (SMMF) probe with a core diameter of 50 μm, outer diameter of 125 μm, and length of 7.4 mm, which is a typical graded-index multimode fiber used for optical communications. The axial and lateral resolutions were measured to be 2.14 μm and 2.3 μm, respectively. Inserting the SMMF 4 mm into the cortex of an in vivo rat brain, depths were scanned from a SMMF facet to 147 μm with a field of view of 47 μm. Three-dimensional (3D) OCM images were obtained at depths from about 20 μm to 90 μm. From morphological information of the resliced 3D images and the dependence of the integration of the OCM image signal on the inserted distance, the 3D information of nerve fibers have been demonstrated.
{"title":"Sectional Imaging of in vivo Rat Brain Using Short Multimode Fiber Probe","authors":"M. Sato, Kai Eto, Junpei Masuta, Kenji Inoue, R. Kurotani, Hiroyuki Abe, I. Nishidate","doi":"10.2530/jslsm.jslsm-40_0053","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0053","url":null,"abstract":"We demonstrate full-field optical coherence microscopy (FF-OCM) using an ultrathin forward-imaging short multimode fiber (SMMF) probe with a core diameter of 50 μm, outer diameter of 125 μm, and length of 7.4 mm, which is a typical graded-index multimode fiber used for optical communications. The axial and lateral resolutions were measured to be 2.14 μm and 2.3 μm, respectively. Inserting the SMMF 4 mm into the cortex of an in vivo rat brain, depths were scanned from a SMMF facet to 147 μm with a field of view of 47 μm. Three-dimensional (3D) OCM images were obtained at depths from about 20 μm to 90 μm. From morphological information of the resliced 3D images and the dependence of the integration of the OCM image signal on the inserted distance, the 3D information of nerve fibers have been demonstrated.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"22 1","pages":"9-17"},"PeriodicalIF":0.0,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87542066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-15DOI: 10.2530/jslsm.jslsm-40_0055
K. Oka, Hiroshi Kobayashi, J. Usuda, K. Yasufuku
A composite-type optical fiberscope was developed for maintenance research and development of nuclear facilities by National Institutes for Quantum and Radiological Science and Technology (QST). It can coaxially deliver both a high-energy laser beam for micro processing and an image from processing targets. At present, we are developing a minimally invasive laser treatment device based on this technology and are expanding into the medical field. This paper introduces these medical applications.
{"title":"Development of the Composite-Type Optical Fiberscope for Medical Use","authors":"K. Oka, Hiroshi Kobayashi, J. Usuda, K. Yasufuku","doi":"10.2530/jslsm.jslsm-40_0055","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0055","url":null,"abstract":"A composite-type optical fiberscope was developed for maintenance research and development of nuclear facilities by National Institutes for Quantum and Radiological Science and Technology (QST). It can coaxially deliver both a high-energy laser beam for micro processing and an image from processing targets. At present, we are developing a minimally invasive laser treatment device based on this technology and are expanding into the medical field. This paper introduces these medical applications.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"8 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79421158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-15DOI: 10.2530/jslsm.jslsm-40_0064
T. Kono
{"title":"How has the Insurance Notification of Lasers and Energy-based Devices in Japan Affected the Clinical Use of These Devices?","authors":"T. Kono","doi":"10.2530/jslsm.jslsm-40_0064","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-40_0064","url":null,"abstract":"","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"24 1","pages":"44-46"},"PeriodicalIF":0.0,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77899669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-15DOI: 10.2530/jslsm.jslsm-41_0007
T. Tsuchida
{"title":"Laser Treatments in the Current Medical Fee Revision 2020","authors":"T. Tsuchida","doi":"10.2530/jslsm.jslsm-41_0007","DOIUrl":"https://doi.org/10.2530/jslsm.jslsm-41_0007","url":null,"abstract":"","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83861196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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