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Photobiomodulation Therapy in Plastic Surgery and Dermatology 整形外科和皮肤病学中的光生物调节疗法
Pub Date : 2020-12-02 DOI: 10.2530/jslsm.jslsm-41_0035
Eiko Nakayama, T. Kushibiki, Yoshine Mayumi, M. Tsuchiya, R. Azuma, T. Kiyosawa, M. Ishihara
As for photobiomodulation therapy, also known as low-reactive level laser therapy (LLLT), various biological effects have been reported, including the promotion of wound healing and alleviation of inflammation. In this article, we will look back on previous reports on the mechanisms of photobiomodulation therapy and describe the clinical effects that can be achieved, with a focus on plastic surgery and dermatology.
至于光生物调节治疗,也被称为低反应水平激光治疗(LLLT),各种生物效应已被报道,包括促进伤口愈合和减轻炎症。在本文中,我们将回顾以往关于光生物调节治疗机制的报道,并描述可实现的临床效果,重点是整形外科和皮肤病学。
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引用次数: 0
Expectation for Advances in Laser Medical Engineering from the Perspective of PDT International Standardization 从PDT国际标准化看激光医疗工程发展的展望
Pub Date : 2020-09-30 DOI: 10.2530/JSLSM.JSLSM-41_0030
Yuki Kawase, S. Kishimoto, H. Iseki, Soko Ikuta, Y. Muragaki
1. はじめに 国際標準は,品質,性能,安全性,仕様,試験方法な どに関する国際的な取決めである.国際標準は,国際規 格として文書化され,各国での規制や製品開発などに引 用・参照されることで,製品の安全担保を担っている. 近年のグローバル化にともなう規制の国際整合の流れか ら,国際規格の産業上の重要性も高まっている. 著者らは,患者の利益や安全の担保と日本の光線力学 的治療(PDT: Photodynamic Therapy)産業の国際競争力 の確保のため,経済産業省の支援のもと,2012年から PDTに関する新規国際規格策定に向けた活動を開始し, 2017年 5月に IEC 60601-2-75として,PDTに関する国際 規格の発行に至った.本稿においては,PDT国際標準化 活動の経緯をまとめるとともに,国際標準の策定,獲得 が製品の安全担保や自国産業の発展にどのように関わっ ているかといった社会的・産業的意義を考察する.さら に,国際標準化から見たレーザ医工学発展への期待とし て,国際規格の中での医工学エビデンスの重要性も述 べる.
首先,国际标准是关于质量、性能、安全性、规格、测试方法等方面的国际性决定。国际标准作为国际规范被书面化,在各国的规章制度和产品开发等方面被引用和参照,从而承担着产品安全担保的责任。近年来,随着全球化的发展,规制逐渐走向国际统一,国际规格在产业上的重要性也在提高。作者们,患者的利益和安全的担保日本的光线力学的治疗(PDT:为了确保(Photodynamic Therapy)产业的国际竞争力,在经济产业省的支持下,从2012年开始开展PDT相关的新国际规格制定活动,2017年5月,IEC 601-2-75发布了PDT相关的国际标准。本文在总结PDT国际标准化活动的经过的同时,还考察了国际标准的制定和获得如何与产品的安全担保以及本国产业的发展相关的社会和产业意义。二,作为从国际标准化角度对激光医学科学发展的期待,阐述了国际规格中医学科学依据的重要性。
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引用次数: 0
「40周年特別企画 レーザー医学を発展させるための提言」の特集によせて 在“40周年特别计划发展激光医学的建议”的特辑中
Pub Date : 2020-09-30 DOI: 10.2530/jslsm.jslsm-41_0029
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引用次数: 0
Dreams and Challenges, toward the Future of Laser Medical Care 梦想与挑战,迈向激光医疗的未来
Pub Date : 2020-09-30 DOI: 10.2530/JSLSM.JSLSM-41_0032
T. Sugai
歴史を振り返ってみれば,日本で初めてレーザ手術装 置(文末注記参照)が医療機器として厚生省(現厚生労 働省)の認可を得て製造・販売が開始されたのは昭和 55 年(1980年)であった.当時はレーザ機器の医療への応 用は一部に限られており,一般にはあまり詳知されてい ない状況が暫く続いたため,これを打破すべく日本レー ザー医学会(以下「当学会」と略す)のもとに医用レー ザ機器の開発,製造,販売に携わる企業が会同し,当学 会分科会の中で製造業者組織化の設立準備が検討されな がら,問題点の解決や普及のための議論が重ねられたこ とがきっかけとなり,昭和 61年(1986年)9月に三十数 社の企業が参画して,日本医用レーザ協会(以下「当協 会」と略す)の前身である『日本医用レーザー機器委員 会』が設立されている. その頃に演者はまだこの分野に深くは関わっておらず, 当時の実相を知らぬままに語ることになるが,レーザ医 療と医用レーザ機器とが共にその後に大きな発展を遂げ た一因は,臨床家による新たな医療技術(夢:ニーズ) へのチャレンジと,学術者によるエビデンス(夢の現実 化)の集積と,それらの要望を受けて各企業が技術挑戦 (課題)に立ち向かい,加えて三者が協働してレーザ医療 という新たな医療確立を目指して行政に働きかけ(課題 の現実化)を行ってきた,その歴史そのものの歩みであっ たと伺える.先例も実績も何も無い処から,工夫と改善 を凝らし,互いに刺激をしながら,レーザ医療は positive に歴史を刻んできたものと思う.この時点での大きなポ イントとして理解しておくべきは,医用レーザ機器は「医 療のニーズ(夢)から生み出されてきた医療機器(課題 現実化の産物)」としての歴史を刻んできていた,という 点であろう(Fig.1参照). その後の経緯として,上述の『日本医用レーザー機器 委員会』は 5年間会合が継続されてきたが,レーザ医療 の継続的な発展の過程を踏まえて,医用レーザ機器自体 の健全な開発,製造,輸入,販売が期待され,また拡販 により普及を図ることが求められた処から,会員企業相 互が研鑽に努めることを設立目的として,平成 3年(1991
回顾历史,昭和55年(1980年),日本首次获得厚生省(现厚生劳动省)的批准,开始制造并销售激光手术装置(参照文末注记)。当时激光设备在医疗上的应用仅限于一部分,一般人对激光设备不太了解的状况持续了一段时间。为了打破这一局面,日本激光医学会(以下简称“本学会”)成立了医用激光器从事电子设备的开发、制造、销售的企业举行了会议,在该学会分科会议中讨论了制造业者组织化的设立准备,并就解决问题和普及问题进行了反复讨论。61年(1986年)9月,由三十多家企业参与的日本医疗激光协会(以下简称“该协会”)的前身“日本医疗激光仪器委员会”成立。那时表演者还没有深入这个领域,在不了解当时实际情况的情况下,激光医学和医用激光仪器在那之后都取得了巨大发展,原因之一是临床家的新医疗技术(梦想:需求)。的挑战,以及学术人员的证据(梦想的现实化)的积累,根据这些要求各企业面对技术挑战(课题),再加上三方协作激光器医疗的新医疗确立为目标,对行政进行推动(课题的现实化),这可以说是历史本身的进程。在没有先例和实际成果的情况下,通过努力和改进,相互激励,激光医疗在positive中书写了历史。应该理解的是,医用激光器作为“从医疗保健的需求(梦想)中诞生的医疗器械(课题现实化的产物)”,谱写了历史的一段历史(参照Fig.1)。之后的经过,上述的“日本医用激光仪器委员会”已经持续召开了5年,鉴于激光医疗不断发展的过程,医用激光仪器本身以健全的开发、制造、进口、销售为目的,并要求通过扩大销售来实现普及,会员企业相互钻研为目的,平成3年(1991年)
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引用次数: 0
Positive Thinking for Developing Laser Surgery and Medicine: Recommendation from Clinical Point of View 积极思考发展激光手术和医学:从临床角度的建议
Pub Date : 2020-09-30 DOI: 10.2530/JSLSM.JSLSM-41_0031
T. Kono
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引用次数: 0
The Possibility of Photobiomodulation Therapy (PBMT) for Skeletal Muscle 骨骼肌光生物调节治疗(PBMT)的可能性
Pub Date : 2020-07-15 DOI: 10.2530/jslsm.jslsm-41_0016
Takahisa Yonezu
Recently, photobiomodulation therapy (PBMT) using laser or light emitting diode (LED) as a light source has been used as a treatment for sports-related disorders. Until now, lasers or LEDs have been mainly used, but a light source that combines laser and LED is also used. In this paper, we will introduce the effects of PBMT before and after exercise, and the effects of PBMT on muscle damage, focusing on recent research reports, and discuss the possibility of using PBMT in clinical settings in future.
近年来,利用激光或发光二极管(LED)作为光源的光生物调节疗法(PBMT)已被用于治疗运动相关疾病。到目前为止,主要使用激光或LED,但也使用激光和LED结合的光源。在本文中,我们将介绍PBMT在运动前后的作用,以及PBMT对肌肉损伤的影响,重点介绍最近的研究报道,并讨论PBMT在临床应用的可能性。
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引用次数: 1
Possibilities of Low Level Laser Therapy in Sports Conditioning 低水平激光治疗在运动调节中的可能性
Pub Date : 2020-07-15 DOI: 10.2530/jslsm.jslsm-41_0013
T. Koyama
Recovery plan after high intensity training is important for the conditioning for athlete. There are scientifically effective recovery methods such as active recovery, cold water immersion and massage. Post-exercise photobiomodulation therapy (PBMT) has showed equal to or better effects than other recovery methods. Most of the PBMT devices in Europe and America are mainly LED or high-power laser comprised of multiple wavelengths. As a practical experience in American football, PBMT is useful for preventing muscle clamp by using at pre-game.
高强度训练后的恢复计划对运动员的体能训练非常重要。有主动恢复、冷水浸泡、按摩等科学有效的恢复方法。运动后光生物调节疗法(PBMT)已显示出与其他恢复方法相同或更好的效果。欧美的PBMT器件多以LED或多波长高功率激光器为主。作为美式橄榄球的实践经验,赛前使用PBMT对预防肌肉夹紧是有益的。
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引用次数: 0
A Mechanism of Cancer Cell Cytotoxicity of Near-Infrared Photoimmunotherapy 近红外光免疫治疗肿瘤细胞毒性机制研究
Pub Date : 2020-07-15 DOI: 10.2530/jslsm.jslsm-41_0020
Kazuhide Sato
Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed next-generation cancer photo-target therapy that combines the specificity of intravenously injected antibodies for targeting tumors with toxicity induced by photoabsorber (IR700) after exposure to NIR-light. NIR-PIT is realized its multidisciplinary method with the combination of the technologies in chemistry, biolody, pharmacology and physics. Presently, NIR-PIT is under the international phase III clinical trial against locoregional, recurrent head and neck SCC (HNSCC) (LUZERA-301, NCT03769506) with FDA fast track approval and expected to be clinically licensed in a few years. However, the precise mechanism of NIR-PIT is still unknown. In this review, the scheme of NIR-PIT and the mechanism of NIR-PIT is outlined.
近红外光免疫疗法(NIR-PIT)是一种新发展的新一代癌症光靶向疗法,它结合了静脉注射抗体靶向肿瘤的特异性和暴露于nir光吸收剂(IR700)后引起的毒性。NIR-PIT采用化学、生物学、药理学和物理学等多学科技术相结合的方法来实现。目前,nil - pit正在进行针对局部区域复发性头颈部鳞状细胞癌(HNSCC)的国际III期临床试验(LUZERA-301, NCT03769506),并已获得FDA快速通道批准,预计将在几年内获得临床许可。然而,NIR-PIT的确切机制尚不清楚。本文综述了NIR-PIT的方案和NIR-PIT的机理。
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引用次数: 2
Appearances of Physical Fatigues after Training in Adult Female Judoists—Examination from Serum Myogenic Enzymes and Immune Functions— 成年女性柔道运动员训练后身体疲劳的表现——血清肌原酶和免疫功能的检测
Pub Date : 2020-07-15 DOI: 10.2530/jslsm.jslsm-41_0004
T. Umeda, Ayumi Tanimoto, Yosuke Yamamoto, Toshihiko Koga, Tadahiro Nomura, M. Tanabe, A. Kojima, Kazuyuki Oyamada, K. Sawada, S. Nakaji
Objective: We examined the symptoms of over-reaching caused by transient judo training in the female judoists from the muscle damage and the immune functions. We examined the possibility of the application of the phototherapy to recovering the over-reaching by transient training from the results of previous studies on phototherapy and exercise. Methods: The subjects of this study were nine of the adult female judoists. The subjects conducted the judo training of 2 hours 30 minutes as transient training. The investigation items were the body compositions, blood biochemistries, neutrophil functions, antioxidant functions. We measured these items before and after the training. Results and discussion: The transient training carried out by our subjects resulted in muscle damage, increased stress and inflammatory response, partly reduced immune function, increased the reactive oxygen species production. Previous studies related to phototherapy and exercise suggested that the phototherapy may be effective for recovery of these symptoms related to over-reaching after the training.
目的:从肌肉损伤和免疫功能两方面探讨女性柔道运动员短暂柔道训练引起的过伸症状。我们结合以往关于光疗和运动的研究结果,探讨了光疗在短暂训练中恢复过伸的可能性。方法:以9名成年女柔道运动员为研究对象。受试者进行2小时30分钟的柔道临时训练。调查项目为体成分、血液生化、中性粒细胞功能、抗氧化功能。我们在训练前后分别测量了这些项目。结果与讨论:我们受试者进行的短暂性训练导致肌肉损伤,应激和炎症反应增加,部分免疫功能降低,活性氧产生增加。以往有关光疗和运动的研究表明,光疗可能对训练后过度伸展相关症状的恢复有效。
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引用次数: 0
Clinical Application of LLLT to Collision Athletes LLLT在碰撞运动员中的临床应用
Pub Date : 2020-07-15 DOI: 10.2530/jslsm.jslsm-41_0015
A. Okayama
Low reactive level laser therapy (LLLT) using low power laser has attracted attention not only for pain relief but also for its contribution to conditioning the players i.e. in improving muscle fatigue in recent years. This article describes the current status of the medical operation in teams and future interventions by LLLT for collision sports involving contact play, specifically rugby, where the author is mainly involved.
近年来,使用低功率激光的低反应水平激光治疗(LLLT)不仅因其缓解疼痛,而且因其对调节球员即改善肌肉疲劳的贡献而受到关注。本文描述了团队医疗操作的现状以及LLLT对涉及接触游戏的碰撞运动的未来干预措施,特别是橄榄球,作者主要参与其中。
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引用次数: 0
期刊
Nippon Laser Igakkaishi
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