Pub Date : 2021-07-15DOI: 10.2530/JSLSM.JSLSM-42_0016
S. Honda
Photodynamic therapy (PDT) in ophthalmology is a therapeutic modality for exudative age-related macular degeneration (AMD). PDT was expected to treat exudative lesion with minimum effect on normal tissue and became the first-choice intervention for AMD for years. However, when the visual outcome of PDT was reported to be inferior than that of the latest anti-VEGF therapy, PDT was no longer performed thereafter except of some specific phenotype of AMD which is still a good candidate of PDT by now. This review article summarizes the past and present of PDT in ophthalmology.
{"title":"The Past and Present of Photodynamic Therapy in Ophthalmology","authors":"S. Honda","doi":"10.2530/JSLSM.JSLSM-42_0016","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0016","url":null,"abstract":"Photodynamic therapy (PDT) in ophthalmology is a therapeutic modality for exudative age-related macular degeneration (AMD). PDT was expected to treat exudative lesion with minimum effect on normal tissue and became the first-choice intervention for AMD for years. However, when the visual outcome of PDT was reported to be inferior than that of the latest anti-VEGF therapy, PDT was no longer performed thereafter except of some specific phenotype of AMD which is still a good candidate of PDT by now. This review article summarizes the past and present of PDT in ophthalmology.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77001736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.2530/JSLSM.JSLSM-42_0011
A. Obana
Carotenoids, which are anti-oxidative agents, protect the human body from various oxidative stresses. Carotenoids exist as macular pigment in the retina and they are measured non-invasively by four methods; heterochromatic flicker photometry, fundus reflectometry, fundus autofluorescence spectroscopy, and resonance Raman spectroscopy. The relation between carotenoids and age-related macular degeneration (AMD) has been studied and the prophylactic effects of supplement containing lutein and zeaxanthin to AMD was reported. Skin carotenoids are measured non-invasively by reflectometry. They are highly correlated with blood concentration of carotenoids and the measurement of carotenoids is useful for food education since it reflects dietary intake.
{"title":"Non-invasive Measurement of Carotenoids in Human Eye and Skin","authors":"A. Obana","doi":"10.2530/JSLSM.JSLSM-42_0011","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0011","url":null,"abstract":"Carotenoids, which are anti-oxidative agents, protect the human body from various oxidative stresses. Carotenoids exist as macular pigment in the retina and they are measured non-invasively by four methods; heterochromatic flicker photometry, fundus reflectometry, fundus autofluorescence spectroscopy, and resonance Raman spectroscopy. The relation between carotenoids and age-related macular degeneration (AMD) has been studied and the prophylactic effects of supplement containing lutein and zeaxanthin to AMD was reported. Skin carotenoids are measured non-invasively by reflectometry. They are highly correlated with blood concentration of carotenoids and the measurement of carotenoids is useful for food education since it reflects dietary intake.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86682499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.2530/JSLSM.JSLSM-42_0008
Y. Miura
Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) is a new imaging modality that measures and maps fluorescence lifetime at the ocular fundus using ultrashort pulse laser. FLIO has the potential to detect not only morphological changes but also subtle changes such as cellular metabolic change or accumulation of metabolism-related products. Therefore, FLIO might serve as a useful tool to detect early signs of diseases, monitor disease progression and evaluate therapeutic effect. This review introduces the principle of FLIO, basic and clinical knowledges to date, and describes the possible role of FLIO adjacent to the treatment of macular diseases.
{"title":"Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO","authors":"Y. Miura","doi":"10.2530/JSLSM.JSLSM-42_0008","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0008","url":null,"abstract":"Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) is a new imaging modality that measures and maps fluorescence lifetime at the ocular fundus using ultrashort pulse laser. FLIO has the potential to detect not only morphological changes but also subtle changes such as cellular metabolic change or accumulation of metabolism-related products. Therefore, FLIO might serve as a useful tool to detect early signs of diseases, monitor disease progression and evaluate therapeutic effect. This review introduces the principle of FLIO, basic and clinical knowledges to date, and describes the possible role of FLIO adjacent to the treatment of macular diseases.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79002666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-15DOI: 10.2530/JSLSM.JSLSM-42_0010
伸 加登本
{"title":"All about OCT Angiography: Principles and Features","authors":"伸 加登本","doi":"10.2530/JSLSM.JSLSM-42_0010","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0010","url":null,"abstract":"","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87832836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-18DOI: 10.2530/JSLSM.JSLSM-42_0017
K. Hirayama, Manabu Yamamoto
Since the 1960’s, laser therapy in the ophthalmologic field, especially for retinal diseases, has made various developments. Selective Retina Therapy (SRT) is one of the minimally invasive lasers that can selectively treat only retinal pigment epithelial cells without affecting the retina or choroid. We have reviewed the principle of SRT, clinical research, and future prospects.
{"title":"Clinical Research of Selective Retina Therapy (SRT) for Retinal Diseases","authors":"K. Hirayama, Manabu Yamamoto","doi":"10.2530/JSLSM.JSLSM-42_0017","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0017","url":null,"abstract":"Since the 1960’s, laser therapy in the ophthalmologic field, especially for retinal diseases, has made various developments. Selective Retina Therapy (SRT) is one of the minimally invasive lasers that can selectively treat only retinal pigment epithelial cells without affecting the retina or choroid. We have reviewed the principle of SRT, clinical research, and future prospects.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88955827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-15DOI: 10.2530/JSLSM.JSLSM-42_0002
H. Funabashi
Although Mongolian spots and ectopic Mongolian spots typically lighten spontaneously, they occasionally persist to adulthood. They can be effectively treated with the Q-switched laser (ruby, alexandrite, Nd:YAG) especially in early childhood. However, complications such as hyperpigmentation and hypopigmentation often occur with laser treatment of Mongolian spots and ectopic Mongolian spots. Therefore, we should take special care to prevent long-term complications.
{"title":"Laser Treatment of Ectopic Mongolian Spot in Childhood","authors":"H. Funabashi","doi":"10.2530/JSLSM.JSLSM-42_0002","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0002","url":null,"abstract":"Although Mongolian spots and ectopic Mongolian spots typically lighten spontaneously, they occasionally persist to adulthood. They can be effectively treated with the Q-switched laser (ruby, alexandrite, Nd:YAG) especially in early childhood. However, complications such as hyperpigmentation and hypopigmentation often occur with laser treatment of Mongolian spots and ectopic Mongolian spots. Therefore, we should take special care to prevent long-term complications.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"352 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74120734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-15DOI: 10.2530/JSLSM.JSLSM-42_0003
F. Amano
Infantile hemangioma (IH) is a self-resolving tumor. However, some patients with IH require revision surgery due to the presence of residual lesions after regression. Our clinical therapeutic strategy for IH involves aggressive interventions using a long pulsed dye laser (595 nm) (including a cooling device with a variable pulse width) to reduce redness, oral propranolol administration, or a combination of both methods. The early intervention strategy used at our clinic eliminates the plaque- and mass-type IH in children aged less than 1 and 2 years, respectively. Beginning treatment at an early stage of IH seems to be important to suppress the growth of the tumor.
{"title":"Treatment Strategy for Infantile Hemangiomas: From the Perspective of A Clinical Dermatologist","authors":"F. Amano","doi":"10.2530/JSLSM.JSLSM-42_0003","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0003","url":null,"abstract":"Infantile hemangioma (IH) is a self-resolving tumor. However, some patients with IH require revision surgery due to the presence of residual lesions after regression. Our clinical therapeutic strategy for IH involves aggressive interventions using a long pulsed dye laser (595 nm) (including a cooling device with a variable pulse width) to reduce redness, oral propranolol administration, or a combination of both methods. The early intervention strategy used at our clinic eliminates the plaque- and mass-type IH in children aged less than 1 and 2 years, respectively. Beginning treatment at an early stage of IH seems to be important to suppress the growth of the tumor.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84026860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-15DOI: 10.2530/JSLSM.JSLSM-42_0005
M. Nagahama
Nevus of Ota is a bluish pigmentation on the face that usually occurs in children at a young age (<1 year) or at puberty. Using Q-switched lasers can effectively trat it; however, the treatment for children is known to be better than that for adults. The skin characteristics of children are different from those of adults. When treating nevus of Ota in children, it is important to consider body growth and mental development that occurs during childhood. This study gives a comprehensive description on laser treatment of nevus of Ota in children.
{"title":"Laser Treatment of Nevus of Ota in Children","authors":"M. Nagahama","doi":"10.2530/JSLSM.JSLSM-42_0005","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0005","url":null,"abstract":"Nevus of Ota is a bluish pigmentation on the face that usually occurs in children at a young age (<1 year) or at puberty. Using Q-switched lasers can effectively trat it; however, the treatment for children is known to be better than that for adults. The skin characteristics of children are different from those of adults. When treating nevus of Ota in children, it is important to consider body growth and mental development that occurs during childhood. This study gives a comprehensive description on laser treatment of nevus of Ota in children.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"33 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74665149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-15DOI: 10.2530/JSLSM.JSLSM-42_0001
Nobuyuki Takeuchi, M. Matsumoto
Effects of non-polarized near-infrared ray irradiation on pressure pain threshold, tactile perception threshold and temporal summation were examined. The subjects were 10 healthy adults. All subjects were participated in both irradiation and control groups. The irradiation group, non-polarized near-infrared rays were applied to thenar eminence of non-dominant hand. The control group was not irradiated. Pressure pain threshold, tactile perception threshold and temporal summation were measured before and after irradiation. The pressure pain threshold value showed a significant increase after non-polarized near-infrared ray irradiation in the irradiation group, but the tactile perception threshold and visual analogue scale value reflecting the temporal summation did not change in the both groups. It was suggested that non-polarized near-infrared ray irradiation increased the pressure pain threshold. On the other hand, it was considered that non-polarized near-infrared ray irradiation does not affect the tactile perception threshold and the temporal summation.
{"title":"Effect of Non-polarized Near-infrared Ray Irradiation on Pressure Pain Threshold, Tactile Perception Threshold and Temporal Summation of Thenar Eminence","authors":"Nobuyuki Takeuchi, M. Matsumoto","doi":"10.2530/JSLSM.JSLSM-42_0001","DOIUrl":"https://doi.org/10.2530/JSLSM.JSLSM-42_0001","url":null,"abstract":"Effects of non-polarized near-infrared ray irradiation on pressure pain threshold, tactile perception threshold and temporal summation were examined. The subjects were 10 healthy adults. All subjects were participated in both irradiation and control groups. The irradiation group, non-polarized near-infrared rays were applied to thenar eminence of non-dominant hand. The control group was not irradiated. Pressure pain threshold, tactile perception threshold and temporal summation were measured before and after irradiation. The pressure pain threshold value showed a significant increase after non-polarized near-infrared ray irradiation in the irradiation group, but the tactile perception threshold and visual analogue scale value reflecting the temporal summation did not change in the both groups. It was suggested that non-polarized near-infrared ray irradiation increased the pressure pain threshold. On the other hand, it was considered that non-polarized near-infrared ray irradiation does not affect the tactile perception threshold and the temporal summation.","PeriodicalId":19350,"journal":{"name":"Nippon Laser Igakkaishi","volume":"52 1","pages":"2-7"},"PeriodicalIF":0.0,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86076882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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