Nuclear medicine and biology最新文献

{"title":"Improvement of novel [18F]FBPA synthesis method from [18F]HF and adopt to automatic synthesizer","authors":"Yasukazu Kanai , Toshimitsu Watanabe , Yoichiro Ohta , Sadahiro Naka , Toshihiro Sakai , Koji Ono , Mitsunori Kirihata","doi":"10.1016/j.nucmedbio.2025.109195","DOIUrl":"10.1016/j.nucmedbio.2025.109195","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109195"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEAD OPTIMIZATION STRATEGY FOR THE DEVELOPMENT OF NEW GRPR RADIOANTAGONISTS","authors":"Priciana Paraiso, Hanyue Ma, Le Li, Debra Stuurman, Corrina de Ridder, Carolien van Deurzen, Yann Seimbille","doi":"10.1016/j.nucmedbio.2025.109152","DOIUrl":"10.1016/j.nucmedbio.2025.109152","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109152"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a 64Cu-labeled bicyclic peptide ligand for targeting nectin-4","authors":"Tobias Krönke, Johanna Trommer, Martin Ullrich, Reik Loeser, Sven Stadlbauer, Klaus Kopka, Jens Pietzsch, Robert Wodtke","doi":"10.1016/j.nucmedbio.2025.109151","DOIUrl":"10.1016/j.nucmedbio.2025.109151","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109151"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of ArB(Epin)s as precursors for copper-mediated radiofluorination","authors":"Tetsuro Tago , Takashi Niwa , Tadashi Takimoto , Takamitsu Hosoya , Jun Toyohara","doi":"10.1016/j.nucmedbio.2025.109187","DOIUrl":"10.1016/j.nucmedbio.2025.109187","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109187"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiolabelling bacteria with 89Zr-DBN for PET/MRI: comparing [89Zr]Zr oxalate and [89Zr]Zr phosphate","authors":"Diksha ,&nbsp;Sarah C. Donnelly ,&nbsp;Mojmir Suchy ,&nbsp;Neil Cockburn ,&nbsp;Frank S. Prato ,&nbsp;Michael S. Kovacs ,&nbsp;Donna E. Goldhawk","doi":"10.1016/j.nucmedbio.2025.109577","DOIUrl":"10.1016/j.nucmedbio.2025.109577","url":null,"abstract":"<div><h3>Purpose</h3><div>Our bodies host a diverse and complex community of bacteria, known as the microbiota, which play a crucial role in overall wellness. The gut microbiota perform essential functions, such as food fermentation, pathogen protection, and vitamin production. Dysbiosis, or the imbalance of these bacterial communities, can disrupt these processes, leading to diseases like cancer, respiratory infections, and neurological disorders. To enable non-invasive tracking of microbial distribution <em>in vivo</em>, this study investigates [⁸⁹Zr]Zr oxalate as a more efficient and cost-effective alternative to [⁸⁹Zr]Zr phosphate for radiolabelling diverse bacterial species for PET/MRI.</div></div><div><h3>Methods</h3><div>To test radiolabelling efficiency, the bifunctional chelator DBN, consisting of desferrioxamine (DFO) to chelate ⁸⁹Zr and a lysine-reactive group (isothiocyanate) for cell surface protein attachment, was used. The bifunctional chelator was mixed with either neutralized [⁸⁹Zr]Zr phosphate (titrated to pH 7 with 1 M K₂CO₃) in HEPES buffer or [⁸⁹Zr]Zr oxalate (titrated to pH 7 with 2 M Na₂CO₃) in phosphate buffered saline (PBS). The efficiency of isotope chelation was evaluated by radio thin layer chromatography (radio-TLC). The efficiency of bacterial conjugation was examined with commensal <em>Lactobacillus crispatus</em> ATCC33820 and probiotic <em>Escherichia coli</em> Nissle 1917. A <em>t</em>-test with unequal variances assessed statistical differences in chelation and bacterial labelling efficiencies.</div></div><div><h3>Results</h3><div>[⁸⁹Zr]Zr oxalate showed significantly higher chelation efficiency to DBN (94.8 ± 5.5 %) compared to [⁸⁹Zr]Zr phosphate (66.6 ± 16.3 %; <em>p</em> &lt; 0.05). Labelling efficiency for <em>L. crispatus</em> improved when [⁸⁹Zr]Zr oxalate was used either after one half-life had passed since production or within 1 half-life but diluted with water in a 1:1 ratio. Optimal labelling provided an average activity per live cell (colony-forming unit, CFU) between 0.003 and 0.12 Bq/CFU, with activities above 0.01 Bq/CFU causing significant bacterial death, while lower activities (below 0.006 Bq/CFU) effectively maintained bacterial viability. Comparable bacterial labelling efficiency results were obtained with <em>Escherichia coli</em> Nissle 1917.</div></div><div><h3>Conclusion</h3><div>This study establishes the first standardized protocol for radiolabelling viable bacteria using ⁸⁹Zr-DBN derived from [⁸⁹Zr]Zr oxalate. This method enables high chelation and labelling efficiency while preserving cell viability and is applicable to both <em>L. crispatus</em> (Gram-positive, facultative anaerobe) and <em>E.coli</em> (Gram-negative, aerobe), supporting its use in PET/MRI based bacterial imaging.</div></div>","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109577"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron-Catalyzed Aminoradiofluorination of Alkenes to Unprotected β-Radiofluoroamines","authors":"Mark R. Bortolus ,&nbsp;Hannah Le ,&nbsp;Neil Vasdev ,&nbsp;Chao Zheng","doi":"10.1016/j.nucmedbio.2025.109120","DOIUrl":"10.1016/j.nucmedbio.2025.109120","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109120"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title/EDB","authors":"","doi":"10.1016/S0969-8051(25)00583-9","DOIUrl":"10.1016/S0969-8051(25)00583-9","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109574"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Evaluation of 203Pb- and 212Pb-Labeled mcp-PSMA Ligands for Radionuclide Theranostics of Prostate Cancer","authors":"Magdalena Blei ,&nbsp;Katarína Hajduová ,&nbsp;Zbynek Novy ,&nbsp;Milos Petrik ,&nbsp;Santiago Brühlmann ,&nbsp;Marc Pretze ,&nbsp;Sven Stadlbauer ,&nbsp;Klaus Kopka ,&nbsp;Constantin Mamat","doi":"10.1016/j.nucmedbio.2025.109097","DOIUrl":"10.1016/j.nucmedbio.2025.109097","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109097"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DO3A conjugated 2-(diphenylphosphoryl)-ethyldiphenylphosphonium cation as a molecular probe for PET/MR bimodality imaging","authors":"Changtong Yang ,&nbsp;David Chee Eng Ng ,&nbsp;Amos Hong Pheng Loh ,&nbsp;Winnie Wing Chuen Lam ,&nbsp;Yiu Ming Khor","doi":"10.1016/j.nucmedbio.2025.109147","DOIUrl":"10.1016/j.nucmedbio.2025.109147","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109147"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Inorganic Materials for a 230Pa/230U/226Th Radionuclide Generator","authors":"Nicholas Becker ,&nbsp;George Diehl ,&nbsp;Tara Mastren","doi":"10.1016/j.nucmedbio.2025.109171","DOIUrl":"10.1016/j.nucmedbio.2025.109171","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109171"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}